125 results about "Immune Factors" patented technology

The invention belongs to the technical field of medicinal and edible formula foodstuffs, and specifically relates to a special diet edible for patients with kidney yin deficiency. Kidney yin means yin-qi and yin-fluid of kidney self, is the yin basis all over the body, and has effects of cooling, moistening, soggy nourishing and limiting excess yang-heat on the whole body. According to the special diet, traditional Chinese medicines with characteristics of whole grains, homology of medicine and food, and new resource foodstuffs are combined together, diet and health preserving are organically combined, so that kidney yin deficiency is conditioned, prevented and resisted. According to the special diet, disease treatment methods as motherland traditional Chinese medicine treasures are inherited, probiotics is creatively utilized as a pioneer and is promoted in propagation, so that microecological balance in intestines is regulated, splenic and gastric motility is enhanced, and drug absorption is accelerated. Probiotics is abundant in multiple active factors, biological immune factors and multiple vitamins. Also according to constitution characteristics of the patients with kidney yin deficiency, multiple natural original-ecological medicinal and edible food materials are added, so that the special diet of the invention has the unique advantage of integration of triple-efficacy comprising dietotherapy, prevention and conditioning.

The invention relates to the chemical and medicinal technology field, and provides compounds with a structural characteristic in formula I and applications of the compounds and pharmaceutically acceptable salts, isomers, racemes, prodrug cocrystallization compounds, hydrates and solvates in preparation of medicines treating or preventing relative diseases with ROR regulation and control. Importantly, the compounds can be used for reducing generation of immunological factors relative to immunological diseases and alleviating immunologic derangement symptoms.

The invention provides infant formula milk powder for improving health of intestinal tracts, which is prepared with raw milk as a main raw material with addition of whey protein powder being rich in MFGM and other materials. By means of the novel whey protein powder being rich in MFGM as the raw material, contents of bio-active substances having special functional components, such as MFGM protein, lactoferrin, phospholipid, gangliosides, sphingomyelin, sialic acid and the like, are increased by regulation of the formula, so that the milk powder can promote colonization of probiotics in intestinal flora of infants and improves the content of immune factors in intestinal tracts and reduces intestinal disease incidence. The formula is suitable for researching on formula milk powder for infants and follow-up infants.

The invention relates to a traditional Chinese medicine ointment, a preparation method and application thereof. The raw materials of the traditional Chinese medicine ointment include: bezoar, the rhizome of Chinese goldthread, the root bark of shaggy-fruited dittany, pepper, radix sophorae flavescentis, barbados aloe, golden larch bark, the tuber of stemona, borneol, menthol crystal and vaseline; and the raw materials are crushed and mixed to prepare the traditional Chinese medicine ointment. The traditional Chinese medicine ointment for the treatment of skin disease can penetrate the thicker skin or realize the desquamation of stratum corneum to have quick efficacy, can quickly kill the surface causative agent, destroy the breeding environment for bacteria, have targeting medicinal efficacy, can clear the toxic substance in blood, inhibit the synthesis of muggy stasis tissue, regulate the metabolic disturbance of cells due to long-term use of hormone drugs, enhance the active ingredients of anti-relapse anti-immune factors, reproduce the newly-generated immune substances, improve skin micro-circulation, repair damaged skin tissues and increase the resistance and immunity.

The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and / or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.

The invention discloses stratiomyiid meal-containing pelteobagrus fulvidraco feed and an application thereof. The stratiomyiid meal-containing pelteobagrus fulvidraco feed comprises the following components in parts by weight: 24-40 of fish meal, 6-23 parts of stratiomyiid meal, 27 parts of soybean meal, 22-24 parts of high protein flour, 0.5 parts of fish oil, 0.2-3.4 parts of soybean oil, 0.5 part of choline chloride, 0.4 part of vitamin premix, 0.4 part of mineral premix, 1 part of phagostimulant and 1-2.5 parts of microcrystalline cellulose. The stratiomyiid meal-containing pelteobagrus fulvidraco feed has the advantages that the novel pelteobagrus fulvidraco feed is prepared by replacing part of fish meal with the stratiomyiid meal and can effectively supply all nutrient substances required for pelteobagrus fulvidraco by matching of the stratiomyiid meal and other raw materials, so that the survival rate and weight gain rate of the pelteobagrus fulvidraco can be effectively ensured; the nonspecific immune factor serum lysozyme activity, serum and hepatopancreas SOD (Superoxide Dismutase) active content and leukocyte phagocytic capacity of the pelteobagrus fulvidraco are obviously improved, and the immunity of the pelteobagrus fulvidraco is remarkably improved.

The invention discloses an active-probiotic-containing feed additive as well as a preparation method and an application thereof. The active-probiotic-containing feed additive is obtained from a lactobacillus, bifidobacterium, bacillus and yeast mixed bacteria solution and auxiliaries by mixing, solid fermentation, low-temperature drying, grinding and compounding with oligosaccharide. The product contains rich bioactive substances (immune factors, organic acids, antibacterial substances and growth promotion substances), various digestive enzymes, bioactive small peptides, free amino acids and various live probiotics. After being added to feed, the feed additive can prevent and treat bacterial diarrhea and lienteric diarrhea, immunity and anti-stress capacity of animal organisms can be improved, digestibility of animals can be improved, feed conversion ratio can be increased, animal growth can be promoted, meat quality and flavor can be improved, use of drugs such as antibiotics and the like can be reduced remarkably or avoided, survival rate of the animals can be increased, production cost can be reduced, and environmental pollution can be reduced.

The present invention discloses a probiotic composition for enhancing immunity and an application of the probiotic composition. The probiotic composition comprises prebiotics, a K-MYL probiotic combination and functional substances, and the K-MYL probiotic combination comprises at least one of lactobacillus casei, lactobacillus bulgaricus, saccharomyces boulardii, lactobacillus reuteri and bifidobacterium animalis, or further comprises at least one of lactobacillus rhamnosus, lactobacillus acidophilus and bifidobacterium longum. The probiotic composition can significantly increase the number of intestinal effective microbial communities, improve intestinal immune functions, improve expressions of intestinal immune factors, resist virus infection and shorten recovery time after the virus infection. Moreover, probiotic strain combinations, the prebiotics, probiotic strains and the functional substances have remarkable synergistic enhancement effects.

The invention relates to a 2-oxo-1,2-dihydrobenzo[cd] indole-6-sulfamide compound and a composition and application thereof. The invention provides a compound with the structural characteristics of the general formula I in the specification serving as a novel retinoic acid orphan nuclear receptor gamma subtype (RORgamma) inhibitor, as well as an application of the compounds and pharmaceutically acceptable salts, isomers, racemes, pro-drug co-crystallization compounds, hydrates and solvates thereof in medicines for treating or preventing RORgamma-regulated related diseases. More importantly, the compounds are possibly used for reducing generation of immune factors related to immunological diseases and alleviating symptoms of immunologic derangement and cancers.

The invention is directed to methods of using Ig compositions to prevent and / or treat humans, livestock and / or domesticated animals suffering from a variety of disorders. The Ig composition comprises a concentrated amount of one or more immunoglobulins selected from the group consisting of alpha, beta, and gamma globulins. Preferably, the Ig composition comprises other antibodies identified as providing an immune response and / or immune factors such as complement. The Ig composition preferably includes immunoglobulins specific to a variety of antigens.

The invention relates to a probiotic fermented Chinese herbal medicine composition capable of preventing and controlling diabetes. The probiotic fermented Chinese herbal medicine composition capable of preventing and controlling diabetes mainly comprises following components, by mass, 100 parts of a probiotic fermented Chinese herbal medicine freeze-dried composition, 1 to 100 parts of a probiotic exopolysaccharide freeze-dried composition, 1 to 100 parts of a Chinese herbal medicine extract, 1 to 10 part of chitosan oligosaccharide , 1 to 10 parts of fructo-oligosaccharide, 1 to 10 parts of inulin, 1 to 10 parts of soluble dietary fiber, and 1 to 10 parts of insoluble dietary fiber. According to a preparation method, the above components are mixed to be uniform so as to obtain the probiotic fermented Chinese herbal medicine composition. The probiotic fermented Chinese herbal medicine composition is capable of preventing diabetes, and controlling and improving diabetes symptoms via changing intestinal flora, promoting intestinal activity, and improving immunity. Qualitative and quantitative representation of the change of in vivo immune factors can be realized via measuring related immune factor and endotoxin levels.

Belonging to the technical field of bio-medicine, the invention discloses a spleen immune factor and its preparation method. The spleen immune factor or specific spleen immune factor is prepared through an ultrafiltration or dialysis method. With a molecular weight less than 20000 Dalton, the spleen immune factor of the invention has proteins absent in a transfer factor as well as high bioactivity. Development and application of the spleen immune factor provided in the invention not only expands the utilization efficiency of animal (chicken, pig etc.) spleen resources, enhances the bioactivity of a spleen extract, but also provides a preparation raw material characterized by easily available crude materials, low cost and no toxic and side effect and used for treating human as well as animal refractory diseases like bird flu and tumors, etc. Therefore, the spleen immune factor of the invention is suitable for industrial production.

The invention discloses a health care food with a spleen and stomach tonifying function and an immunity enhancing function, which is prepared from active components in parts by weight: 100 to 500 parts of tuckahoe, 100 to 500 parts of hawthorn, 50 to 300 parts of needle mushroom, 50 to 300 parts of Chinese dates, 20 to 200 parts of tremella, and 20 to 200 parts of champignons. The invention also discloses a preparation method of the health food. The heath care food has the functions of tonifying qi, the spleen and the stomach and warming and recuperating intestines and stomach. Meanwhile, thehealth care food of the invention has the efficiencies of protecting immune organs of children, activating immune cells, stimulating secretion of immune factors, enhancing immunity of children, and improving physical conditions of children. The preparation technology of the health care food is simple and scientific and is capable of ensuring that the health care product prepared by the preparation technology has the efficiencies.

The invention discloses a co-culture system for liver cells and Kupffer cells and application thereof. The co-culture system is characterized in that in a Millicell double-layer culture room, 1-100 ng / mL LPS (lipopolysaccharides) is added into a culture medium, the Kuffer cells are cultured in the upper layer of the Millicell double-layer culture room, and the liver cells are cultured in the lower layer of the Millicell double-layer culture room; and half of the fresh culture medium is replaced every other day so as to keep the concentration of the LPS. The co-culture system for liver cells and Kupffer cells provided by the invention has the advantages that the Kupffer cells continuously secrete inflammatory cell factors (such as TNF-alpha) in vitro after being stimulated by the LPS; the liver cells can generate a great number of enzymes, such as AST (aspartate aminotransferase), ALT (alanine transaminase) and GGT (gamma-glutamyl transpeptidase) in the environment so as to stimulate the liver injury based on immunoreaction caused by the immune / inflammation response after the liver tissue undergoes virus infection in vivo; and moreover, the co-culture system is used for screening medicaments resisting immune liver injury according to the influence of the medicaments on the secretion amount of immune factors and the enzymatic activity.

This invention relates to extraction process of camel colostrum immunoglobulin IgA and IgG, belongs to biochemistic product field. The camel colostrum is the most prolific natural source of immunoglobulin, and is one of the biotic resources that has most concentrated immune factor. This invention supplies a craft of using gradient elution to extract IgA and using ultrafiltration and metal chelate chromatography to extract IgG. By test has show that in product IgA basicly has no other impurity, purity of IgG can reach 97 percent and above.

A composition and method for preventing HIV infection of mammalian cells. One aspect of the invention relates to an anti-immunodeficiency virus immunokine capable of binding to a cellular protein in a manner that prevents HIV infection of that cell. The compositions can include either an active bioactive polypeptide, such as native cobratoxin, and / or an inactivated bioactive polypeptide, such as cobratoxin in which one or more of the native disulfide bridges have been prevented from forming. The term “immunokine” is used to refer to an inactivated bioactive polypeptide, whether inactivated by chemical, genetic, and / or synthetic means as described herein, with the proviso that a corresponding active bioactive polypeptides can be included where applicable (e.g., for in vitro use).

The invention discloses a lactating-sow special feed. The lactating-sow special feed is prepared from, by weight, 40 parts of corn, 30 parts of wheat shorts, 8 parts of soya bean meal, 5 parts of cottonseed meal, 5 parts of fermented rice hulls, 5 parts of phoenix mushroom powder, 3 parts of decavitamin, 2 parts of traditional Chinese medicine extract, 2 parts of lysine, 1 part of cysteine, 1 part of phytase, 0.5 part of mountain flour, 0.5 part of calcium hydrophosphate and 0.8 part of salt, wherein the traditional Chinese medicine extract is prepared from radix asparagi, climbing fig fruits, chickweed and licorice roots. The lactating-sow special feed is scientifically matched, and the obtained feed can meet nutrients required by lactating-period sows; meanwhile, traditional Chinese medicine ingredients are added into the feed formula, sow milk production can be further promoted, the in-vivo immune factor level of the sows can be improved, and therefore the survival rate of piglets can be increased.

The invention discloses a kit for detection or assisted detection of tuberculous pleurisy. The kit comprises a device for detecting the expression amount of an immune factor, wherein the immune factor comprises (1) IL-6, IL-13, G-CSF, CCL1, CCL21, IP-10 (CXCL10), CCL8 (MCP-2), CXCL9 (MIG) and CXCL12 (SDF-1); or (2) at least one of IL-6, IL-13, G-CSF, CCL1, CCL21, IP-10 (CXCL10), CCL8 (MCP-2), CXCL9 (MIG) and CXCL12 (SDF-1). Experiments prove that a method for specifically identifying tuberculous pleurisy by taking hydrothorax as a detection object, utilizing a group of immunologic molecular marker, and adopting a multiple-factor microsphere detection technique is developed, and the purposes of improving the disease diagnosis accuracy rate, scientifically judging the state of illness and the like are realized by a multiple-factor combination manner.

The invention provides a lentinan calcium complex, and a preparation method and application thereof. The method comprises the steps of: adding a calcium chloride solution to an aqueous solution of lentinan with stirring, at 40-80 DEG C, regulating a pH value to 7-10 with sodium hydroxide, and continuously stirring for 1 h for a complex reaction; removing free calcium ions by a dialysis method; and concentrating and freeze-drying the lentinan compound solution to obtain the lentinan calcium complex with calcium content of 5.2mg / g. Compared with a blank group, the lentinan calcium complex can obviously promote mouse macrophage RAW264.7 to release immune factors, such as a tumor necrosis factor TNF-alpha and a cell factor IL-6. The preparation method of the lentinan calcium complex provided by the invention is simple and easy for practice. Besides, as an organic calcium, the lentinan calcium complex can also promote calcium absorption and improve immunity.

The invention discloses lactobacillus acidophilus capable of relieving ulcerative colitis and application of the lactobacillus acidophilus, and belongs to the technical field of microorganisms. According to the invention, a strain of lactobacillus acidophilus CCFM1200 is screened, and the lactobacillus acidophilus CCFM1200 has the effect of relieving ulcerative colitis caused by DSS, which is specifically reflected as follows: (1) the weight loss of mice with ulcerative colitis is reduced; (2) the colon length of a mouse with ulcerative colitis is obviously increased; (3) the immune factor level in the colons of the mice with ulcerative colitis is obviously improved; (4) the expression quantity of cell chemokine receptors in colons of mice with ulcerative colitis is obviously reduced; (5) the content of short-chain fatty acid in excrement of mice with ulcerative colitis is obviously increased; and (6) regulating intestinal flora of the mouse with ulcerative colitis. The lactobacillus acidophilus CCFM1200 disclosed by the invention has a huge application prospect in the aspect of preparing food or medicines for preventing and / or treating ulcerative colitis.

The invention belongs to the technical field of biological pharmacy, and specifically relates to a chimeric antigen receptor (CAR) targeting GPC3 and anticancer applications. The chimeric antigen receptor includes signal peptide, an antigen binding region targeting GPC3, a hinge region, a transmembrane region, a costimulating factor and an intracellular signal domain. The growth of tumors in vivoand in vitro can be effectively inhibited by selecting the antigen binding region targeting the GPC3 and having medium affinity and adjusting the connection sequence of variable regions of a light chain and heavy chain, so that the secretion levels of immune factors can be reduced; and the chimeric antigen receptor has good clinical application prospects.

The invention discloses a probiotic composition. The probiotic composition comprises lactobacillus acidophilus, bifidobacterium lactis, sorbitol, natural fruit powder, prebiotics, citric acid and silicon dioxide, wherein the natural fruit powder comprises elderberry fruit powder and acerola cherry fruit powder, and the prebiotics comprise inulin, resistant dextrin and stachyose. According to the probiotic composition provided by the invention, extreme immunological factors are effectively reduced, the usage quantity of external use dermatitis medicines is reduced, and besides, digestion of children is promoted; natural fruit powder (the elderberry fruit powder and the acerola cherry fruit powder) promoting immunization and health is used for collocation, an embedding technique is not used,and suspicious anaphylactogen of essence, pigment and the like is not added, so that extreme immunization can be effectively avoided, intestinal floras of children are regulated, and metabolism and discharge of anaphylactogen are promoted.

The invention provides children's functional drink. According to a technical scheme of the invention, the children's functional drink is prepared from, by weight, 10-30 parts of white granulated sugar, 11-15 parts of active component B, 9-13 parts of active ingredient, 2-6 parts of sodium hydrogen phosphate, 0.3-0.5 part of Hami melon essence, 3-5 parts of glucose, and 105-135 parts of water. The children's functional drink has rich nutrition and good taste, contains immune factors required by human bodies, can promote the growth and development of bodies, adjust gastrointestinal function, improve bodily immunity, refresh milk and enhance fatigue resistance, has significant health effect for the diseases such as heart, blood vessels and cervical vertebra; the children's functional drink is suitable for general people, especially children, and can significantly improve the growth and development of children and supplement energy.

The invention discloses an application of bee venom lipid nanoparticles, which relates to the technical field of biological science and a pharmaceutical carrier. The bee venom lipid nanoparticles of the invention are composed of bee venom hybrid polypeptide and phospholipid and cholersteryl ester. The immune activation and anticancer agent prepared by the bee venom lipid nanoparticles is used fortargeting antigen presenting cells, and activates antigen presenting cells to improve the immune microenvironment, so as to generate a systemic immune response and inhibit tumor growth and metastasiseffect; the agent is also used to target and activate dendritic cells, macrophages, and B cells to inhibit the production of distant tumors; and the agent is also used to target hepatic sinusoidal endothelial cells and induce them to release a variety of immune factors to inhibit tumor liver metastasis. The immune activation and anticancer agent prepared by the bee venom lipid nanoparticle has notoxic and side effects, does not depend on the tumor type, and has good anti-tumor effect.

The invention provides suckling piglet formula liquid feed for piglets from birth to two-week age. The nutrition ingredients of the feed comprise the following ingredients in parts by mass: 5 to 20 parts of whey protein concentrate, 14 to 30 parts of sprayed dried plasma protein powder, 0 to 10 parts of dried porcine soluble powder, 2 to 15 parts of spray-dried animal blood cells, 0 to 10 parts of puffing rice powder, 0 to 10 parts of casein, 10 to 30 parts of whole milk powder, 8 to 20 parts of water-soluble coconut oil powder, 5 to 20 parts of milk fat, 2 to 18 parts of high-protein whey powder, 0 to 10 parts of glucose, 0 to 10 parts of lactose and 2 to 10 parts of composite nutrition regulation and control agents. The formula liquid feed provided by the invention conforms to the physiological development characteristics and the nutrition substances requirements of piglets; the nutrition supply is enhanced; the breast milk quantity insufficiency and nutrition unbalance are supplemented; the high-quality protein, fat and immune factors are supplemented; the piglet intestinal tract development is regulated and controlled; the utilization efficiency of nutrition substances is improved; the body immunologic function is improved; the piglet health level and the success rate are improved.

The invention discloses a low-temperature elicitor and a using method thereof and belongs to the field of elicitors for enhancing plant resistance. The low-temperature elicitor is prepared by well mixing well-chosen fulvate, imported fermented chelatase, salicylic acid and Glucose antifreezing immune factor according to a weight ratio of 1:1.5-2:1.5-2:2.5-3. The using method includes following steps: A, increasing fertilizer to strengthen seedlings: applying organic fertilizer and phosphorus-potassium fertilizer to fruit plants at autumn to improve carbon-nitrogen ratio; B, using enzyme for stimulation: starting from late October, applying environment-friendly enzyme prepared by fermenting waste bud, flower and fruit of same fruit plants, brown sugar and water every other 12-18 days, and consecutively using the enzyme for three times to stimulate plant hormone; C, spraying the low-temperature elicitor: adding water to dilute the low-temperature elicitor according to a proportion of 1:600 5-8 days before cooling of each time, and uniformly spraying the low-temperature elicitor to the plants. The low-temperature elicitor can improve cold resistance, improve quality of vegetables and fruits, increase yield and induce stress resistance.

The present invention discloses lactose intolerance and protein allergy preventing formula milk powder for children of 12-36 months, and belongs to the technical field of formula food. Every 100 g of the child formula milk powder contains 18-30 g of concentrated hydrolyzed whey protein powder. The concentrated hydrolyzed whey protein powder contains lactose and the formula milk powder contains the lactose content of 0-0.5 g / 100 g. The formula milk powder is applicable to children of 12-36 months and overcomes the child lactose intolerance and milk protein allergy symptoms. The concentrated hydrolyzed whey protein is used as a raw material and can very relieve the lactose intolerance symptoms of children. Docosahexaenoic acids, arachidonic acids, prebiotics of galactooligosaccharide and fructo-oligosaccharide, an immune factor of lactoferrin are scientifically added and the ingredients of lutein and nucleotides are also strengthened, so that the formula milk powder can meet the needed various nutrients of the children for normal development.

The invention aims to provide a nutritional composition, which comprises alpha-casein, gamma-casein, k-casein, alpha-whey protein, and lactoferrin, and applications thereof in common food, health carefood, and medicine. The invention further provides a preparation method of alpha-whey protein. The provided nutritional composition can effectively enhance the immunity and infection resistant performance of infants and children, is similar with the immune factor of human milk, and is capable of preventing iron-deficiency anemia.

An attenuated rabies virus for use as a live vaccine is provided. The attenuated rabies virus expresses an immune factor that enhances immune response upon administration of the live vaccine.