124 results about "Immune Factors" patented technology

The invention belongs to the technical field of medicinal and edible formula foodstuffs, and specifically relates to a special diet edible for patients with kidney yin deficiency. Kidney yin means yin-qi and yin-fluid of kidney self, is the yin basis all over the body, and has effects of cooling, moistening, soggy nourishing and limiting excess yang-heat on the whole body. According to the special diet, traditional Chinese medicines with characteristics of whole grains, homology of medicine and food, and new resource foodstuffs are combined together, diet and health preserving are organically combined, so that kidney yin deficiency is conditioned, prevented and resisted. According to the special diet, disease treatment methods as motherland traditional Chinese medicine treasures are inherited, probiotics is creatively utilized as a pioneer and is promoted in propagation, so that microecological balance in intestines is regulated, splenic and gastric motility is enhanced, and drug absorption is accelerated. Probiotics is abundant in multiple active factors, biological immune factors and multiple vitamins. Also according to constitution characteristics of the patients with kidney yin deficiency, multiple natural original-ecological medicinal and edible food materials are added, so that the special diet of the invention has the unique advantage of integration of triple-efficacy comprising dietotherapy, prevention and conditioning.

The invention relates to the chemical and medicinal technology field, and provides compounds with a structural characteristic in formula I and applications of the compounds and pharmaceutically acceptable salts, isomers, racemes, prodrug cocrystallization compounds, hydrates and solvates in preparation of medicines treating or preventing relative diseases with ROR regulation and control. Importantly, the compounds can be used for reducing generation of immunological factors relative to immunological diseases and alleviating immunologic derangement symptoms.

The invention provides infant formula milk powder for improving health of intestinal tracts, which is prepared with raw milk as a main raw material with addition of whey protein powder being rich in MFGM and other materials. By means of the novel whey protein powder being rich in MFGM as the raw material, contents of bio-active substances having special functional components, such as MFGM protein, lactoferrin, phospholipid, gangliosides, sphingomyelin, sialic acid and the like, are increased by regulation of the formula, so that the milk powder can promote colonization of probiotics in intestinal flora of infants and improves the content of immune factors in intestinal tracts and reduces intestinal disease incidence. The formula is suitable for researching on formula milk powder for infants and follow-up infants.

The invention discloses stratiomyiid meal-containing pelteobagrus fulvidraco feed and an application thereof. The stratiomyiid meal-containing pelteobagrus fulvidraco feed comprises the following components in parts by weight: 24-40 of fish meal, 6-23 parts of stratiomyiid meal, 27 parts of soybean meal, 22-24 parts of high protein flour, 0.5 parts of fish oil, 0.2-3.4 parts of soybean oil, 0.5 part of choline chloride, 0.4 part of vitamin premix, 0.4 part of mineral premix, 1 part of phagostimulant and 1-2.5 parts of microcrystalline cellulose. The stratiomyiid meal-containing pelteobagrus fulvidraco feed has the advantages that the novel pelteobagrus fulvidraco feed is prepared by replacing part of fish meal with the stratiomyiid meal and can effectively supply all nutrient substances required for pelteobagrus fulvidraco by matching of the stratiomyiid meal and other raw materials, so that the survival rate and weight gain rate of the pelteobagrus fulvidraco can be effectively ensured; the nonspecific immune factor serum lysozyme activity, serum and hepatopancreas SOD (Superoxide Dismutase) active content and leukocyte phagocytic capacity of the pelteobagrus fulvidraco are obviously improved, and the immunity of the pelteobagrus fulvidraco is remarkably improved.

The present invention discloses a probiotic composition for enhancing immunity and an application of the probiotic composition. The probiotic composition comprises prebiotics, a K-MYL probiotic combination and functional substances, and the K-MYL probiotic combination comprises at least one of lactobacillus casei, lactobacillus bulgaricus, saccharomyces boulardii, lactobacillus reuteri and bifidobacterium animalis, or further comprises at least one of lactobacillus rhamnosus, lactobacillus acidophilus and bifidobacterium longum. The probiotic composition can significantly increase the number of intestinal effective microbial communities, improve intestinal immune functions, improve expressions of intestinal immune factors, resist virus infection and shorten recovery time after the virus infection. Moreover, probiotic strain combinations, the prebiotics, probiotic strains and the functional substances have remarkable synergistic enhancement effects.

The invention relates to a 2-oxo-1,2-dihydrobenzo[cd] indole-6-sulfamide compound and a composition and application thereof. The invention provides a compound with the structural characteristics of the general formula I in the specification serving as a novel retinoic acid orphan nuclear receptor gamma subtype (RORgamma) inhibitor, as well as an application of the compounds and pharmaceutically acceptable salts, isomers, racemes, pro-drug co-crystallization compounds, hydrates and solvates thereof in medicines for treating or preventing RORgamma-regulated related diseases. More importantly, the compounds are possibly used for reducing generation of immune factors related to immunological diseases and alleviating symptoms of immunologic derangement and cancers.

The invention is directed to methods of using Ig compositions to prevent and/or treat humans, livestock and/or domesticated animals suffering from a variety of disorders. The Ig composition comprises a concentrated amount of one or more immunoglobulins selected from the group consisting of alpha, beta, and gamma globulins. Preferably, the Ig composition comprises other antibodies identified as providing an immune response and/or immune factors such as complement. The Ig composition preferably includes immunoglobulins specific to a variety of antigens.

The invention relates to a probiotic fermented Chinese herbal medicine composition capable of preventing and controlling diabetes. The probiotic fermented Chinese herbal medicine composition capable of preventing and controlling diabetes mainly comprises following components, by mass, 100 parts of a probiotic fermented Chinese herbal medicine freeze-dried composition, 1 to 100 parts of a probiotic exopolysaccharide freeze-dried composition, 1 to 100 parts of a Chinese herbal medicine extract, 1 to 10 part of chitosan oligosaccharide , 1 to 10 parts of fructo-oligosaccharide, 1 to 10 parts of inulin, 1 to 10 parts of soluble dietary fiber, and 1 to 10 parts of insoluble dietary fiber. According to a preparation method, the above components are mixed to be uniform so as to obtain the probiotic fermented Chinese herbal medicine composition. The probiotic fermented Chinese herbal medicine composition is capable of preventing diabetes, and controlling and improving diabetes symptoms via changing intestinal flora, promoting intestinal activity, and improving immunity. Qualitative and quantitative representation of the change of in vivo immune factors can be realized via measuring related immune factor and endotoxin levels.

Belonging to the technical field of bio-medicine, the invention discloses a spleen immune factor and its preparation method. The spleen immune factor or specific spleen immune factor is prepared through an ultrafiltration or dialysis method. With a molecular weight less than 20000 Dalton, the spleen immune factor of the invention has proteins absent in a transfer factor as well as high bioactivity. Development and application of the spleen immune factor provided in the invention not only expands the utilization efficiency of animal (chicken, pig etc.) spleen resources, enhances the bioactivity of a spleen extract, but also provides a preparation raw material characterized by easily available crude materials, low cost and no toxic and side effect and used for treating human as well as animal refractory diseases like bird flu and tumors, etc. Therefore, the spleen immune factor of the invention is suitable for industrial production.

The invention discloses a co-culture system for liver cells and Kupffer cells and application thereof. The co-culture system is characterized in that in a Millicell double-layer culture room, 1-100 ng/mL LPS (lipopolysaccharides) is added into a culture medium, the Kuffer cells are cultured in the upper layer of the Millicell double-layer culture room, and the liver cells are cultured in the lower layer of the Millicell double-layer culture room; and half of the fresh culture medium is replaced every other day so as to keep the concentration of the LPS. The co-culture system for liver cells and Kupffer cells provided by the invention has the advantages that the Kupffer cells continuously secrete inflammatory cell factors (such as TNF-alpha) in vitro after being stimulated by the LPS; the liver cells can generate a great number of enzymes, such as AST (aspartate aminotransferase), ALT (alanine transaminase) and GGT (gamma-glutamyl transpeptidase) in the environment so as to stimulate the liver injury based on immunoreaction caused by the immune/inflammation response after the liver tissue undergoes virus infection in vivo; and moreover, the co-culture system is used for screening medicaments resisting immune liver injury according to the influence of the medicaments on the secretion amount of immune factors and the enzymatic activity.

This invention relates to extraction process of camel colostrum immunoglobulin IgA and IgG, belongs to biochemistic product field. The camel colostrum is the most prolific natural source of immunoglobulin, and is one of the biotic resources that has most concentrated immune factor. This invention supplies a craft of using gradient elution to extract IgA and using ultrafiltration and metal chelate chromatography to extract IgG. By test has show that in product IgA basicly has no other impurity, purity of IgG can reach 97 percent and above.

The invention provides a detection method for genotyping of human platelet alloantigen (HPA). The detection method is characterized in that a target fragment is obtained by designing a specific primerand then using a single-tube multiplex PCR amplification reaction; a single base extension primer is designed and then single base extension is performed; then a target DNA sequence is accurately measured by mass spectrometry. The platelet alloantigen HPA-1 to 21 bw allele can be detected at one time. Then a mass spectrum is typed directly, and data are directly output. A whole process is closed,the time is short, and the cost is low. Through detecting the genotyping of the platelet alloantigen of a patient and a blood donor, platelets matching successfully can be found, and the problem of ineffective platelet infusion caused by immune factors is effectively avoided. A detection kit product is low in cost and more accurate, and the detection method is expected to be a routine clinical detection method to replace a serological detection method.

The invention discloses a lactating-sow special feed. The lactating-sow special feed is prepared from, by weight, 40 parts of corn, 30 parts of wheat shorts, 8 parts of soya bean meal, 5 parts of cottonseed meal, 5 parts of fermented rice hulls, 5 parts of phoenix mushroom powder, 3 parts of decavitamin, 2 parts of traditional Chinese medicine extract, 2 parts of lysine, 1 part of cysteine, 1 part of phytase, 0.5 part of mountain flour, 0.5 part of calcium hydrophosphate and 0.8 part of salt, wherein the traditional Chinese medicine extract is prepared from radix asparagi, climbing fig fruits, chickweed and licorice roots. The lactating-sow special feed is scientifically matched, and the obtained feed can meet nutrients required by lactating-period sows; meanwhile, traditional Chinese medicine ingredients are added into the feed formula, sow milk production can be further promoted, the in-vivo immune factor level of the sows can be improved, and therefore the survival rate of piglets can be increased.

The invention discloses a kit for detection or assisted detection of tuberculous pleurisy. The kit comprises a device for detecting the expression amount of an immune factor, wherein the immune factor comprises (1) IL-6, IL-13, G-CSF, CCL1, CCL21, IP-10 (CXCL10), CCL8 (MCP-2), CXCL9 (MIG) and CXCL12 (SDF-1); or (2) at least one of IL-6, IL-13, G-CSF, CCL1, CCL21, IP-10 (CXCL10), CCL8 (MCP-2), CXCL9 (MIG) and CXCL12 (SDF-1). Experiments prove that a method for specifically identifying tuberculous pleurisy by taking hydrothorax as a detection object, utilizing a group of immunologic molecular marker, and adopting a multiple-factor microsphere detection technique is developed, and the purposes of improving the disease diagnosis accuracy rate, scientifically judging the state of illness and the like are realized by a multiple-factor combination manner.

The invention provides a lentinan calcium complex, and a preparation method and application thereof. The method comprises the steps of: adding a calcium chloride solution to an aqueous solution of lentinan with stirring, at 40-80 DEG C, regulating a pH value to 7-10 with sodium hydroxide, and continuously stirring for 1 h for a complex reaction; removing free calcium ions by a dialysis method; and concentrating and freeze-drying the lentinan compound solution to obtain the lentinan calcium complex with calcium content of 5.2mg / g. Compared with a blank group, the lentinan calcium complex can obviously promote mouse macrophage RAW264.7 to release immune factors, such as a tumor necrosis factor TNF-alpha and a cell factor IL-6. The preparation method of the lentinan calcium complex provided by the invention is simple and easy for practice. Besides, as an organic calcium, the lentinan calcium complex can also promote calcium absorption and improve immunity.

The invention belongs to the technical field of biological pharmacy, and specifically relates to a chimeric antigen receptor (CAR) targeting GPC3 and anticancer applications. The chimeric antigen receptor includes signal peptide, an antigen binding region targeting GPC3, a hinge region, a transmembrane region, a costimulating factor and an intracellular signal domain. The growth of tumors in vivoand in vitro can be effectively inhibited by selecting the antigen binding region targeting the GPC3 and having medium affinity and adjusting the connection sequence of variable regions of a light chain and heavy chain, so that the secretion levels of immune factors can be reduced; and the chimeric antigen receptor has good clinical application prospects.

The invention discloses a probiotic composition. The probiotic composition comprises lactobacillus acidophilus, bifidobacterium lactis, sorbitol, natural fruit powder, prebiotics, citric acid and silicon dioxide, wherein the natural fruit powder comprises elderberry fruit powder and acerola cherry fruit powder, and the prebiotics comprise inulin, resistant dextrin and stachyose. According to the probiotic composition provided by the invention, extreme immunological factors are effectively reduced, the usage quantity of external use dermatitis medicines is reduced, and besides, digestion of children is promoted; natural fruit powder (the elderberry fruit powder and the acerola cherry fruit powder) promoting immunization and health is used for collocation, an embedding technique is not used,and suspicious anaphylactogen of essence, pigment and the like is not added, so that extreme immunization can be effectively avoided, intestinal floras of children are regulated, and metabolism and discharge of anaphylactogen are promoted.

The invention provides children's functional drink. According to a technical scheme of the invention, the children's functional drink is prepared from, by weight, 10-30 parts of white granulated sugar, 11-15 parts of active component B, 9-13 parts of active ingredient, 2-6 parts of sodium hydrogen phosphate, 0.3-0.5 part of Hami melon essence, 3-5 parts of glucose, and 105-135 parts of water. The children's functional drink has rich nutrition and good taste, contains immune factors required by human bodies, can promote the growth and development of bodies, adjust gastrointestinal function, improve bodily immunity, refresh milk and enhance fatigue resistance, has significant health effect for the diseases such as heart, blood vessels and cervical vertebra; the children's functional drink is suitable for general people, especially children, and can significantly improve the growth and development of children and supplement energy.

The invention provides suckling piglet formula liquid feed for piglets from birth to two-week age. The nutrition ingredients of the feed comprise the following ingredients in parts by mass: 5 to 20 parts of whey protein concentrate, 14 to 30 parts of sprayed dried plasma protein powder, 0 to 10 parts of dried porcine soluble powder, 2 to 15 parts of spray-dried animal blood cells, 0 to 10 parts of puffing rice powder, 0 to 10 parts of casein, 10 to 30 parts of whole milk powder, 8 to 20 parts of water-soluble coconut oil powder, 5 to 20 parts of milk fat, 2 to 18 parts of high-protein whey powder, 0 to 10 parts of glucose, 0 to 10 parts of lactose and 2 to 10 parts of composite nutrition regulation and control agents. The formula liquid feed provided by the invention conforms to the physiological development characteristics and the nutrition substances requirements of piglets; the nutrition supply is enhanced; the breast milk quantity insufficiency and nutrition unbalance are supplemented; the high-quality protein, fat and immune factors are supplemented; the piglet intestinal tract development is regulated and controlled; the utilization efficiency of nutrition substances is improved; the body immunologic function is improved; the piglet health level and the success rate are improved.

The invention discloses a low-temperature elicitor and a using method thereof and belongs to the field of elicitors for enhancing plant resistance. The low-temperature elicitor is prepared by well mixing well-chosen fulvate, imported fermented chelatase, salicylic acid and Glucose antifreezing immune factor according to a weight ratio of 1:1.5-2:1.5-2:2.5-3. The using method includes following steps: A, increasing fertilizer to strengthen seedlings: applying organic fertilizer and phosphorus-potassium fertilizer to fruit plants at autumn to improve carbon-nitrogen ratio; B, using enzyme for stimulation: starting from late October, applying environment-friendly enzyme prepared by fermenting waste bud, flower and fruit of same fruit plants, brown sugar and water every other 12-18 days, and consecutively using the enzyme for three times to stimulate plant hormone; C, spraying the low-temperature elicitor: adding water to dilute the low-temperature elicitor according to a proportion of 1:600 5-8 days before cooling of each time, and uniformly spraying the low-temperature elicitor to the plants. The low-temperature elicitor can improve cold resistance, improve quality of vegetables and fruits, increase yield and induce stress resistance.

The invention aims to provide a nutritional composition, which comprises alpha-casein, gamma-casein, k-casein, alpha-whey protein, and lactoferrin, and applications thereof in common food, health carefood, and medicine. The invention further provides a preparation method of alpha-whey protein. The provided nutritional composition can effectively enhance the immunity and infection resistant performance of infants and children, is similar with the immune factor of human milk, and is capable of preventing iron-deficiency anemia.