183 results about "Allergen" patented technology

The invention relates to the technical field of atlas generation, in particular to a children cross-allergen risk dynamic atlas generation system, which comprises the following steps: firstly, determining sensitivity indexes according to immune response conditions of each type of allergens in all allergy detection processes; according to the similarity of each allergen and other allergens in two dimensions of allergen protein structure and IgE level, combining the sensitivity index, and comprehensively representing the cross reaction risk index of each allergen in each allergy detection process; then comprehensively determining the cross-allergy risk degree of various allergens in each season period according to the increasing trend of the cross-allergy risk index curve in each season period and the overall size of the cross-allergy risk index in combination with the characteristic that the cross-allergy reaction possibly caused by the season change is dynamically changed; and the cross allergen risk dynamic map generated in real time according to the cross allergen risk degree is more accurate.

The present invention provides a composition for use in the prevention and / or treatment of a viral infection in an individual wherein the composition comprises Bifidobacterium longum subsp. Infantis and a mixture of HMO consisting of 2 '-fucosyllactose (2FL), difucosyllactose (DFL), lactose-N-tetraose (LNT), 6'-sialyllactose (6SL), 3 '-sialyllactose (3SL), and 3-fucosyllactose (3FL). The present invention also provides compositions for use in preventing and / or reducing the risk of allergen sensitization, preventing and / or reducing the risk of developing respiratory disorders in an individual, and / or preventing and / or reducing the risk of developing asthma in an individual.

The invention discloses manganese-based Prussian blue-polyacrylic acid / polyvinyl alcohol hydrogel for preventing and treating allergic rhinitis. Monodisperse manganese-based Prussian blue nanoparticles synthesized by taking polyacrylic acid as a template are stably immobilized in a polyacrylic acid / polyvinyl alcohol hydrogel matrix. The obtained composite hydrogel membrane has the following prominent advantages: the composite hydrogel membrane has excellent hydrogel characteristics, including controllable membrane thickness, good tissue adhesion and air permeability; reliable biocompatibility and safety are shown; allergen permeation is effectively blocked through a physical barrier effect; prussian blue is continuously released in the slow-release degradation process, active oxygen free radicals are remarkably removed, and the powerful anti-inflammatory effect is achieved. Due to the synergistic effect of double mechanisms of protection and treatment, the material has important clinical application value and development potential in the fields of prevention and treatment of allergic rhinitis.

The invention discloses a preparation method and application of a cat main allergen FEL-1 nano antibody FEL-1-Nb, and relates to the technical field of antibody preparation, and the preparation method comprises the following steps: preparing an immunogen; animal immunization and library construction; constructing and panning a phage display library; screening and identifying positive clone; and expression and purification of the nano antibody: cloning the positively cloned VHH gene to an expression vector such as a pET series, transforming an expression strain such as escherichia coli BL21 (DE3), carrying out IPTG induced expression, and purifying through an inclusion body purification method to obtain a high-purity nano antibody protein. The nano antibody FEL-1-Nb provided by the invention can be specifically bound with a cat main allergen FEL-1 protein, the unique amino acid sequence of the nano antibody FEL-1-Nb is shown as SEQIDNO: 1, high-affinity binding with the FEL-1 protein is ensured, the positive clone binding rate is high through phage display panning and ELISA verification, the phage recovery rate after the third round of panning is increased by more than 1000 times compared with the first round of panning, and the positive clone binding rate is higher than that of the first round of panning. Therefore, the nano antibody has excellent targeted recognition capability.

The present invention aims to treat hay fever by providing water from which pollen (an allergen) has been removed using the pollen treatment facility C of the present invention. [Solution] In a water treatment system consisting of a water tower B, a water treatment plant D, a sand filtration area E, and a water distribution reservoir F, a pollen treatment facility is provided to remove pollen from the river water 1 supplied to the water treatment plant D.

The invention relates to the technical field of allergen proteins and antigen epitopes, and discloses an Antarctic krill allergen and an identification method and application of the Antarctic krill allergen, the Antarctic krill allergen and the antigen epitopes are used for identifying the Antarctic krill allergen and the antigen epitopes, and the identification method comprises the steps of Antarctic krill crude protein extraction, Antarctic krill allergen screening and identification. Extracting an antarctic krill map and verifying allergens; analyzing the homology of the euphausia superba and analyzing the conformation of tropomyosin of the euphausia superba; carrying out euphausia superba tropomyosin epitope analysis; and allergens and epitopes of the euphausia superba are applied. According to the invention, the antarctic krill allergen is identified as tropomyosin, eight antigen epitopes of the antarctic krill tropomyosin allergen are ascertained, the stability change rule in the hot working process is analyzed by utilizing the identified antarctic krill allergen and antigen epitopes, and the result shows that the stability of the antarctic krill allergen is greatly improved under the processing condition of 140 DEG C or below. And the conformation of the tropomyosin of the euphausia superba and the binding capacity of the tropomyosin with protein immune globulin E or immune globulin G are kept stable.

There is provided a method for decreasing leakage of matter from an object to a surrounding, said object being coated with a coating at least partially applied on the object, said coating comprising an at least partially covering layer comprising silver, said object optionally comprising area(s) without said layer, said coating comprising metal particles applied on the layer and optionally on areas without said layer, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, niobium, neodymium and platinum and wherein the amount of the metal particles is in the interval 0.01-8 μg / cm . Advantages include that leakage of matter such as latex allergens of metal ions can be reduced while the coating is both biocompatible and antimicrobial. Further, the blood clotting can be reduced.

The invention discloses an enzyme preparation for degrading allergens of pet food and application of the enzyme preparation, the enzyme preparation is a pH-responsive acrylic resin-pectin composite double-response shell embedded enzyme-probiotic composite system, a core layer is heat-resistant neutral protease, and a middle layer is a compound of lactobacillus reuteri and bacillus subtilis. In the processing stage, the protease degrades macromolecular allergens, the composite shell in the gastrointestinal environment firstly triggers outer acrylic resin to be dissolved through weak alkalinity of the intestinal tract, then inner pectin is degraded by pancreatin, and probiotics are accurately released to metabolize residual sensitizing peptides. The enzyme preparation realizes full-chain desensitization, is high in survival rate of probiotics, is suitable for various pet foods, and is stable and reliable in desensitization effect.

This invention discloses an essence for repairing hormone-induced facial dermatitis and its application, belonging to the field of cosmetics and skin repair technology. The essence uses deionized water as the main solvent, with butylene glycol and glycerin as the core moisturizing base. It is compounded with five major active ingredients: niacinamide, Bacillus ferment precipitate, mussel extract, sodium hyaluronate, and allantoin, supplemented with auxiliary components such as 1,3-propylene glycol, capryloyl hydroxamic acid, 1,2-hexanediol, ethylhexylglycerin, disodium EDTA, and ethanol. Through scientific compounding, a synergistic repair system is formed, achieving integrated effects of skin barrier repair, anti-inflammatory soothing, microecological balance regulation, deep moisturizing and water locking, and redness reduction and stabilization. The formula of this invention is gentle and non-irritating, free of hormones, fragrances, pigments, and strong allergens, suitable for use on hormone-induced facial dermatitis, dermatitis-prone skin, and severely sensitive skin. The product has good stability, high safety, and is suitable for industrial production, possessing significant skin repair value and promising market application prospects.

The present invention provides a universal protein renaturation method and an application thereof, and relates to the technical field of protein renaturation. The method includes the following steps: (1) add 2mercaptoethanol to urea solution to obtain denaturing solution; (2) dissolve a sample including to-be-renatured protein by using the denaturing solution and then freeze the sample, to obtain a frozen body; (3) thaw the frozen body at room temperature, and extract the thawed liquid as soon as the liquid is thawed; (4) dilute the extracted liquid with water, to terminate renaturation and obtain supernatant and precipitate through centrifugation, where the supernatant includes the protein that has been successfully renatured. According to the present invention, protein renaturation recovery efficiency can be improved, and a production batch is stable and reproducible. Operations in the present invention are simple, almost no waste liquid is produced, and no protein is lost. According to the present invention, nine allergen proteins are renatured, to significantly improve the protein renaturation yield. In addition, compared with that in the conventional technology, the protein activity according to the present invention is increased by about 3 times or more.

A sublingual tablet and application thereof in desensitization therapy drug are provided. The sublingual tablet is a low-dose allergen sublingual tablet. The sublingual tablet includes freeze-dried powder of allergen protein, lactose, mannitol, low substituted hydroxypropyl cellulose, low moisture microcrystalline cellulose, and magnesium stearate. The freeze-drying process is adopted to obtain the freeze-dried powder of allergen protein, and the powder direct compression technology is adopted to obtain the sublingual tablet of allergen protein. The low-dose sublingual tablet has excellent properties, including appearance, hardness, tablet weight variation, disintegration time, taste, and uniformity of content, in particular has outstanding advantages in disintegration time, uniformity of content, stability, and preparation process, and has an industrial application prospect.

The invention discloses an application of glucopyranose galactooligosacharide in preparation of a medicine for treating and / or preventing allergic asthma. The invention finds that the glucopyranose galactooligosaccharide can obviously relieve airway inflammatory reaction of an allergen-induced allergic asthma model, including reducing airway inflammatory factor level, improving airway hyperreactivity and reducing lung inflammatory cell infiltration, and has no abnormal influence on blood routine and main organ functions; the composition has the advantages of small drug application dosage, low pharmaceutical cost, high safety, remarkable drug effect and the like, and has a wide application prospect.

The present application relates to novel immunotherapeutic compositions and uses thereof. The present invention relates generally to an immunotherapeutic composition. More specifically, the present invention relates to an immunotherapeutic composition that immunointeracts with T lymphocytes in a subject suffering from peanut allergy or allergy to other tree nuts. Such compositions preferably react immunologically with T cells in a subject suffering from an allergy to an Ara h 1 and / or Ara h 2 allergen. The compositions of the present invention are useful in the therapeutic or prophylactic treatment of conditions characterized by an abnormal, improper or otherwise unwanted immune response to peanut, Ara h1 and / or Ara h2, or a derivative or homolog thereof.

Methods and devices are provided for treating a food allergy in a subject in need thereof. The method entails delivering an effective amount of an allergen associated with the food allergy into the subject's cutis skin layer. Delivering the allergen is carried out by inserting one or more allergen-coated solid microneedles into the subject's skin. The one or more solid microneedles each has a base, shaft and tip, and when inserted in the subject, do not extend beyond the cutis. The allergen is allowed to dissociate from the one or more microneedles while inserted in the subject's cutis. Once the allergen disassociates, the one or more microneedles is removed from the subject's skin.

The invention provides an allergy risk prediction method and device based on indoor physical environment simulation and electronic equipment, and relates to the technical field of medical health data analysis, and the method comprises the steps: constructing a parameterized three-dimensional building model based on spatial information; based on the three-dimensional building model and the external meteorological parameters, coupled physical field simulation is carried out on sunlight, natural lighting and natural ventilation conditions in the target building space, and quantitative environment field distribution data is obtained; matching and fusing the environment field distribution data with a preset risk mapping rule based on allergen breeding physical conditions, identifying and dividing different levels of environment risk areas in the target building space, and generating a visual risk distribution map with space coordinates; and generating a personalized report containing a targeted environment intervention strategy bound with the spatial position based on the specific risk area position and the grade thereof in the risk distribution map. According to the method, quantitative environment data support is provided, and health suggestions are upgraded from experience judgment to data decision.

The present invention provides novel antigens of an allergy to fish, methods and kits for diagnosing an allergy to fish, pharmaceutical compositions comprising such an antigen, fishes, fish eggs or processed products of such fish or fish egg in which such an antigen is eliminated, fishes that deliver such fish eggs or are born from such fish egg, and a tester for determining the presence or absence of a fish antigen in an object of interest. The present invention also relates to polypeptides comprising an epitope of an antigen, kits, compositions and methods for diagnosing an allergy, comprising such a polypeptide, pharmaceutical compositions comprising such a polypeptide, and raw materials or processed products in which an antigen comprising such a polypeptide is eliminated or reduced. The present invention further relates to a tester for determining the presence or absence of an antigen in an object of interest.

The invention discloses a nasal cavity biological protection preparation, a preparation method and application thereof and a nasal cavity intelligent protection system. The formulation comprises a mucin inspired polymer having a specific "brush-like bottleneck" molecular configuration, and an interpenetrating network formed from oppositely charged polysaccharides, which construct a three-dimensional hydrated gel by dynamic non-covalent cross-linking. The gel has the characteristics of shear thinning, strong mucous membrane adhesion and efficient particle interception. Temperature-sensitive, pH-sensitive or oxidation-reduction-sensitive intelligent microspheres can also be integrated in the preparation, so that responsiveness protection to the external environment is realized. The invention further provides an intelligent protection scheme comprising the preparation, a quantitative spraying device and a simple monitoring system. The preparation is safe and free of medicine, is suitable for preventing nasal cavity discomfort caused by air pollution, allergens, viruses and environment dryness, and is especially suitable for daily health protection under high-risk environment or extreme weather conditions.

The invention provides a crop allergen dynamic baseline construction and trusted sharing system based on a multi-dimensional heterogeneous data cube, and the system comprises a collection layer which is used for collecting physical information metadata of a to-be-detected sample based on an agricultural environment monitoring terminal, the method comprises the following steps: performing physical detection on a to-be-detected sample through a high-throughput sequencing terminal to generate original mass spectrum data and transcriptome data, and calling meteorological metadata of a region where the to-be-detected sample is located through a third-party meteorological server; the core processing layer is used for generating a dynamic baseline by adopting a central processing server cluster based on the physical information metadata, the original mass spectrum data, the transcriptome data and the meteorological metadata; and the application layer is used for checking the dynamic baseline based on the user query terminal and checking the GLP log based on the checking and auditing terminal. By constructing the multi-dimensional heterogeneous data cube and the dynamic baseline model, standardized data calculation service is provided for safety evaluation of transgenic crops and biotechnology products.

The application discloses an anti-nasal allergy gel production optimization method based on data analysis, and particularly relates to the field of resource allocation and production optimization, and is used for solving the problem that the response to regional and seasonal demand changes in the existing anti-allergy gel production process is lagging behind, and the raw material supply constraint and the production line switching cost are difficult to balance. The method collects raw material supply chain data, market sales records and environmental allergen time series data, constructs a unified space-time correlation data basis, predicts the anti-allergy response intensity in the future production cycle by using a recurrent neural network, and forms product dosage form preference weights based on association rule mining. On this basis, combined with the raw material inventory and the delivery cycle constraint, a plurality of executable candidate production schemes are generated, and further, the schemes are selected according to the real-time state of the production line and the switching cost, so as to realize the fine configuration and efficient execution of the anti-nasal allergy gel production process.

The present invention relates to interleukin-1 (IL-1) and a composition containing the same for use in the prevention and / or treatment of allergies, particularly in desensitization methods. The present invention also relates to a composition containing IL-1 together with an allergen, a medical device containing the same, and a desensitization kit.

The invention provides a technology for identifying or quantifying allergens of pollen, mould, mites and the like. The detection device uses a plurality of semiconductor sensors. The plurality of semiconductor sensors exhibit relatively different response characteristics to the same gas composition. The detection device acquires the signal patterns detected by the plurality of semiconductor sensors, identifies or quantifies the allergen from the plurality of signal patterns, and outputs an identification or quantification result.

A gene related to biosynthesis of ergothioneine is provided. Based on five synthesis genes of ergothioneine in Mycobacteroides abscessus, only an encoding sequence of each of the five genes is retained, and a gene structure of an encoding region in each gene is optimized to obtain genes related to the biosynthesis of the ergothioneine that are stably expressed in rice. These genes have sequences set forth in SEQ ID NO: 1 to SEQ ID NO: 5, and encoded proteins thereof have amino acid sequences set forth in SEQ ID NO: 6 to SEQ ID NO: 10. The gene is transferred into rice to construct a transgenic rice molecular farm to produce the ergothioneine. As a molecular farm, rice seeds do not contain alkaloids or allergens that are harmful to the human body. Moreover, biosynthesized ergothioneine shows the advantages of easy extraction and processing and of low production cost.

This invention discloses a lutein-infused massage and care eye ointment containing precious Chinese medicinal herbs, free of eight major allergens, and suitable for all ages. Each tube contains 10 grams. The formula uses lutein as its core ingredient, combined with artificial musk, bear bile powder, pearl powder, ginseng, and Ganoderma lucidum, along with eye-protecting ingredients such as wolfberry, chrysanthemum, cassia seed, and buddleja flower. It is supplemented with sodium hyaluronate and vitamin B6, using medical-grade hypoallergenic petrolatum as a base. The ointment is strictly free of eight major allergens, making it safe and gentle, suitable for people aged 3 to 100. This invention features a simple process, can be industrially produced, and can effectively relieve eye fatigue, dry eyes, itchy eyes, bloodshot eyes, dark circles, eye bags, wrinkles, photophobia, and tearing in the wind, among other sub-healthy eye problems. It has extremely high market application and health care value.

The present invention provides a temperature-corrected analyte detection method, and relates to the following steps: after a series of analyte calibrators with different concentrations are added into an immunoassay test strip, using an optical analyzer to measure, at each segmented temperature point, a signal value generated after the analyte calibrator of each concentration is captured on a detection pad of the immunoassay test strip; drawing a corresponding equation by taking a T / C value at each segmented temperature point as an X axis and the concentration of the analyte calibrator as a Y axis; and then, performing temperature segmentation according to n selected segmented temperature points, and in different temperature segments, using different formulas to perform calculation. The temperature-corrected analyte detection method can be used for more accurately detecting myocardial markers, upper respiratory tract viral infections, metabolic hormones, gastrointestinal panel markers, allergens, and the like on the basis of time-resolved fluorescence immunoassay.

This invention discloses an oral liquid for middle-aged and elderly men to cleanse blood, protect the brain, and promote hair growth, as well as its preparation method, belonging to the field of functional health food technology. Each bottle contains 50ml net content, one bottle daily, and is free of eight major allergens. The ingredients include resistant dextrin, erythritol, DHA algal oil microcapsule powder, phosphatidylserine, natto freeze-dried powder, various medicinal and edible extracts, ginseng, vitamins, folic acid, and purified water. This invention upgrades a solid beverage into an easily absorbed oral liquid dosage form, which is rapidly absorbed, does not harm the stomach and intestines, and can cleanse blood vessels, purify blood, assist in regulating blood pressure, blood sugar, and cholesterol, prevent and intervene in Alzheimer's disease, improve memory, and promote hair growth and darkening. The production process is mature and stable, suitable for industrial production, and is specially designed for middle-aged and elderly men, making it safe for long-term consumption.

We provide the system. [Solution] A means for receiving image information or text information entered by a user, Image analysis means for extracting text data from the aforementioned image information, A natural language processing means for identifying allergen components from the aforementioned text data, A comparative determination means for determining allergy risk by comparing the aforementioned allergen component with the user's allergy information, A means for presenting the results of the allergy risk assessment to the user, A system that includes this.

A vehicle includes a controller with a processor and memory. The controller features an allergen sensitivity detection module. A physiological sensor suite in the vehicle is configured to identify an occupant's physiological response. The vehicle also includes an air quality sensor suite with air quality sensors and at least one camera that defines a field of view encompassing the occupant. The allergen sensitivity detection module contains instructions configured to instruct the processor to detect an occupant's physiological response, identify a correlation between the occupant's physiological response and a detected allergen, and generate a response based on the identified correlation.

Described herein relates to an active force electric field anti-pathogenic fabric device and methods thereof used to remove pathogens from an environment surrounding the fabric. The device may be woven into daily clothing items, personal protective equipment, and / or other clothing items typically worn by a user. The device may include a current-carrying mesh that may be coated with active materials used to remove pathogens from the air. As such, the device may operate as an anti-pathogenic material that may be used to remove harmful particles from an area surrounding a user. Accordingly, microorganisms, smoke particles, industrial pollutants, odor molecules, and / or allergens may be structurally disassociated into harmless protein fragments and / or natural molecules when encountering the purifying agents in the device.