3885results about "Vaccination/ovulation diagnostics" patented technology

An automated urinary output (“UO”)-measuring system includes a fluid container including a console coupled to one or more ultrasonic sensors and one or more accelerometers. The console includes a processor configured to receive accelerometer values from the one or more accelerometers, to determine an acceleration state of the fluid container, to activate the one or more ultrasonic sensors when the acceleration state of the fluid container is below a threshold, and to measure a volume of fluid in the fluid container when the acceleration state of the fluid container is zero. The system can further include a removable valve coupled to the fluid container and an attachment device including a pocket configured to accommodate the fluid container.

Apparatuses and methods for recovering solid tissue and dislodged cells (“D-cells”) from a biopsy are disclosed herein. In an embodiment, a biopsy container apparatus for recovering solid tissue and D-cells from a biopsy includes a receiving container and a sieve container. The receiving container has a receiving chamber with an upper opening and a watertight bottom surface. The sieve container is configured to be located at least partially within the receiving chamber and removed from the receiving chamber through the upper opening. The sieve container has a bottom sieve surface including a plurality of apertures configured to pass the D-cells from the biopsy but not the solid tissue from the biopsy into the receiving chamber after the solid tissue and the D-cells from the biopsy are placed into the sieve container.

The invention relates to the technical field of chronic kidney disease screening, and discloses an intelligent chronic kidney disease early screening instrument which comprises a physiological parameter detection module configured to synchronously collect multi-dimensional bio-electricity signals, optical characteristic parameters and body fluid biochemical parameters of a subject and output original signals; the multi-modal data processing module is in communication connection with the physiological parameter detection module and is configured to receive original signals, perform time domain and frequency domain conjoint analysis and construct a parameter incidence matrix; the wireless communication module is configured to realize encrypted interaction between the screening data and the cloud server and block chain evidence storage; and the man-machine interaction module is configured to display the risk level map in real time. According to the method, holographic dynamic correlation modeling of kidney function related micro-electrophysiological fluctuation and optical metabolism characteristics is realized, and a specific cross-modal pathological correlation mode of early renal injury can be effectively identified based on a time-frequency domain combined characteristic extraction and dynamic coupling algorithm.

A mask-based diagnostic apparatus is provided for detecting a biomarker contained in exhaled breath of a test subject. An exhaled breath condensate (EBC) collector converts breath vapor received from the lungs and airways of the test subject into a fluid biosample. The EBC collector including a thermal mass, a condensate-forming surface and a fluid conductor disposed on the condensate-forming surface. A fluid transfer system receives the fluid biosample from the EBC collector. A biomarker testing unit receives the fluid biosample from the fluid transfer system and tests the fluid biosample for a target biomarker. A testing system support is provided for supporting the EBC collector, the fluid transfer system and the biomarker testing unit. The testing system support is configured and dimensioned to fit inside a face mask. A face mask is provided forming an exhaled breath vapor containment volume to hold the exhaled breath vapor in proximity to the EBC collector to enable the condensate-forming surface cooled by the thermal mass to coalesce the exhaled breath vapor into the fluid biosample.

The ureter and urine bag comprises a urine bag body, a spiral pipe, a connecting pipe, a threaded connector pipe and a urine guiding pipe, the threaded connector pipe comprises a pipe body and an insertion pipe, internal threads with the thread pitch being 1.8-2.2 mm are machined on the inner wall of the pipe body, external threads matched with the internal threads are machined on the outer wall of the insertion pipe, and the spiral pipe is connected with the connecting pipe. Two groups of wing plates are symmetrically arranged on the outer wall of the cannula to provide rotating acting points, and a collecting assembly is integrated on the side wall of the urine bag and used for aseptically collecting urine samples. Traditional plug-pull type connection is replaced by a precise thread fit structure, a clear rotating force application point is provided for medical staff, operation is labor-saving and convenient, connector pollution is avoided, the urinary tract infection risk is effectively reduced, and the nursing comfort of a patient is improved.

To provide an image processing device, an image processing method, and an image processing program that enable a distance of an inner cannula in which a puncture needle projects to be easily checked as compared to a case of manually measuring the distance.SOLUTION: A control part performs processing of displaying a virtual position 36 that a distal end of an inner cannula reaches so as to be superimposed on a CT image 38 on the basis of predetermined distance information to the distal end of the inner cannula when the inner cannula projects from an outer cannula 32.SELECTED DRAWING: Figure 4

A system and method for automatically digesting, culturing and growing a biopsy. The digester is a closed fluid transfer system, including disposable and durable parts, that receives a biopsy, washes the biopsy tissue, digests the tissue to separate the cells from each other, and seeds the cells in a culture flask. In one use, the system receives cells from a patient, expands and multiplies them, and returns them to the patient. A controller coordinates the motion of a plurality of pumps and the status of a plurality of valves, the pumps and the plurality of valves moving the fluid throughout the system. A sensor system assists the controller in volume and flow rate control of the fluids in the system, and in controlling the position of a tube providing air and fluids to a biopsy vial that includes the biopsy.

An intracorporeal robot (1) for deployment in a body tract, comprising: - a permanent magnet constituting an effector magnet (2) configured to be guided by an extracorporeal actuating magnet (105), and - a medical device (3) coupled to the effector magnet, the medical device comprising a shape memory structure (4) configured for tetherless actuation by an extracorporeal shape memory actuator (105).

The invention relates to the technical field of medical instruments, in particular to a uterine cavity tissue cutting biopsy device which comprises an outer tube, an inner tube, an inner tube pushing and rebounding mechanism and a negative pressure collecting mechanism, the inner tube pushing and rebounding mechanism and the negative pressure collecting mechanism are connected with the inner tube, the outer tube is provided with a cutting sampling opening, the inner tube is provided with a cutting head, and the inner tube pushing and rebounding mechanism drives the inner tube to axially move back and forth. The negative pressure sampling device further comprises a rotary rebound mechanism which is nested outside the inner pipe, and the inner pipe pushes the rebound mechanism to drive the inner pipe to axially move back and forth and rotate and rebound at the same time, so that the cutting head is driven to rotate and cut back and forth. According to the uterine cavity tissue cutting biopsy device, an external power source is not needed, heat damage can be thoroughly eliminated, sufficient and effective cutting can be achieved without additional driving force and additional operation during use, the integrity of a cut sample can be kept as far as possible, and the uterine cavity tissue cutting biopsy device has the advantages of being free of heat damage, free of noise, free of vibration, convenient to operate and capable of avoiding inaccurate pathological examination.

The invention provides a puncture guiding device and method for an intelligent diagnosis and treatment system and the intelligent diagnosis and treatment system, and belongs to the technical field of intelligent medical treatment, and the puncture guiding device comprises a focus and puncture parameter determining module which is used for determining a focus area and puncture parameters of a target part; the path planning module is used for planning a motion path of the puncture driving component based on the focus area and the puncture parameters and outputting the motion path; the receiving module is used for receiving the real-time monitoring information in the puncture process of the puncture needle on the target part; the displacement determination module is used for determining the displacement of the focus area based on the real-time monitoring information; and the dynamic adjusting module is used for dynamically adjusting the motion path of the puncture driving part based on the displacement and outputting the adjusted motion path. The movement path of the puncture driving component is dynamically adjusted by monitoring the displacement of the focus area and the state of the puncture driving component in real time, so that the puncture process can adapt to the dynamic change of the target part.

The utility model relates to the field of antigen detection kits, and discloses an infectious bovine rhinotracheitis virus antigen detection kit which comprises a box body, a roller is rotatably connected to the bottom side in the box body, a clamping groove is formed in the upper side of the roller, a clamping pin is connected to the clamping groove in a clamping mode, and a placing table is fixedly connected to the upper side of the clamping pin. A plurality of swab placing grooves, an extraction tube placing groove and a detection card placing groove are respectively formed in the upper side of the placing table, the plurality of swab placing grooves, the extraction tube placing groove and the detection card placing groove are distributed in a circumferential array, and sampling swabs are arranged on the inner sides of the plurality of swab placing grooves; according to the utility model, a plurality of groups of sampling swabs, sample extraction tubes and antigen detection cards which are distributed in a circumferential array manner are placed on the placement table, so that when sampling personnel go to cattle for sampling one by one, the sampling personnel can rotate to detection materials such as the next group of antigen detection cards and the like only by pressing down the push rod and switching the angle of the placement table, and the operation is convenient and the use is simple.

The invention belongs to the technical field of expiration detection, and particularly relates to an intelligent expiration tail end gas sampling device and method. The device specifically comprises a shell, a circuit board, a carbon dioxide sensor, a pressure sensor, a baffle, a top cover, a suspension plate, an air pump, a relay, a breathing mask, a mask connector with an internal small cavity, a thermal desorption tube, a TD tube, a Bluetooth module, an air path channel, a silicone tube and the like. End-expiratory gas collection is achieved through accurate triggering and flow control, and dead space gas mixing is avoided; collected gas is directly enriched into a thermal desorption (TD) adsorption tube, so that the loss of VOCs in the transmission and storage process is reduced; and through quantitative sampling volume control and an optimized pipeline material / structure, the adsorption / release and background pollution of the device body to the sample are reduced, so that the representativeness and sensitivity of sampling and the repeatability among different operators / different places are improved.

The invention discloses a non-invasive intestinal flora fixed-point sampling and drug release device, and belongs to the technical field of micro-ecological diagnosis and treatment. The device comprises a shell, an internal storage bin, a medicine loading cavity and a channel switching mechanism. The shell adopts a capsule-shaped design, and an enteric coating is arranged on the surface of the shell, so that the function is started after the shell reaches a specified position of an intestinal tract. Through the internal ingenious mechanism linkage design, the device can firstly complete non-invasive fixed-point sampling of intestinal contents, and after the sampling action is completed, a drug release mechanism is automatically triggered, so that accurate drug delivery of the same part is realized. Cooperative operation of sampling and drug release in time sequence and space is achieved, and the problems of pain, disjunction of the diagnosis and treatment process, poor drug targeting and the like caused by traditional invasive operation are effectively solved. The device is flexible in structural design, has the advantages of being noninvasive, efficient, accurate in time sequence control and the like, and is suitable for integrated application of diagnosis and treatment of various digestive tract diseases such as inflammatory bowel disease management, micro-ecological regulation and the like.

The invention provides a GelMA microneedle patch loaded with chromogenic gold nano bipyramids and a preparation method thereof.The method comprises the steps that citric acid, chloroauric acid and a CTAC solution are mixed, then sodium borohydride is added, and a seed solution is obtained through stirring and standing; mixing chloroauric acid, silver nitrate, hydrochloric acid and CTAB (cetyltrimethyl ammonium bromide), and sequentially adding ascorbic acid and the seed solution to obtain a growth solution; carrying out centrifugation, morphology regulation and chemical etching purification to obtain a chromogenic gold nano bipyramid solution; the preparation method comprises the following steps: reacting gelatin with methacrylic anhydride in PBS, dialyzing and freeze-drying to obtain GelMA; dissolving GelMA in the gold nanoparticle bipyramid solution, and adding a photoinitiator LAP to obtain a mixed precursor solution; and the GelMA microneedle patch loaded with the gold nano bipyramid is prepared through mold casting, centrifugation, ultraviolet light crosslinking and drying demolding. The microneedle extraction and gold nano bipyramid color development integrated scheme is initiated, blood sampling is not needed, the dermis interstitial fluid is extracted in a minimally invasive mode through the microneedle, detection pain and trauma are reduced, the cross infection risk of blood treatment is avoided, and the microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle

Disclosed embodiments include apparatuses, systems, and methods for preventing buckling of an elongated instrument as it is advanced through a channel. In an illustrative embodiment, an apparatus includes an anti-buckling device including at least one movable support bracket. The bracket includes a generally planar member having an inner orifice and an outer edge configured to movably engage an inner surface of a channel. The planar member is configured to provide lateral support to an elongated instrument chosen from one of a needle and a probe responsive to the elongated instrument being motivated through the channel by an actuator. The at least one bracket also includes a positioning member that extends from the planar member. The positioning member is configured to prevent the planar member from twisting within the channel. The positioning member is configured to move relative to a distal end of the actuator so as not to impede movement of the actuator.

An apparatus includes a housing, a flow control mechanism, and an actuator. At least a portion of the flow control mechanism is movably disposed within the housing. The apparatus further includes an inlet port and an outlet port, and defines a fluid reservoir. The outlet port is fluidically coupled to a second fluid reservoir and is fluidically isolated from the first fluid reservoir. The actuator is configured to move the flow control mechanism between a first configuration, in which the inlet port is placed in fluid communication with the fluid reservoir such that the fluid reservoir receives a first flow of bodily-fluid, and a second configuration, in which the inlet port is placed in fluid communication with the outlet port.

Doubly labeled water with enhanced protocol. One embodiment is a method including providing, to a user, a doubly labeled water (DLW) dose for the user to ingest, the DLW dose including deuterium and oxygen-18, wherein an amount of the deuterium is less than 0.12 grams per kilogram (g / kg) of body water of the user, and wherein an amount of the oxygen-18 is less than 0.18 g / kg of body water of the user. The method also includes receiving, from the user, a non-cooled shipment of urine samples collected in connection with ingestion of the DLW dose, wherein the urine samples remain uncooled after collection and during transit for a period of up to 24 days. The method further includes processing the urine samples with a liquid water isotope analyzer to determine one or more metabolic parameters of the user.

A bone marrow aspiration device includes an outer cannula connected to an outer handle, and a first cannula that fits through the outer cannula and extends beyond a distal end of the outer cannula. The first cannula is connected to a first handle including a mating feature. A removable sharp stylet fits coaxially through the first cannula and is connected to a stylet handle including a mating feature to engage with the mating feature of the first handle, to couple the stylet handle to the first handle. A proximal end of stylet forms an adapter to couple to a drill, the first cannula and stylet rotating together when driven by the drill coupled to the adapter. A second cannula fits through the first cannula once the stylet is removed, a distal end of the second cannula closing off the distal end of the first cannula but leaving open one or more side apertures in the first cannula, to aspirate bone marrow through the open side apertures. A screw mechanism, formed by a lead screw extending from the first handle and engaging a threaded portion of the outer handle, allows the first cannula to be retracted through the outer cannula with rotation of the first handle relative to the outer handle.

A suturing system for a scope having a scope shaft includes a drive shaft extending along the scope shaft, a mounting ring attached to a distal end of the scope shaft to receive the drive shaft, a pinion gear attached to the distal end of the drive shaft, a ring gear rotatably mounted to the mounting ring in engagement with the pinion gear, and a needle attached to the ring gear. A method includes coupling a suturing device to a distal portion of an endoscope shaft, rotating a drive shaft extending along the endoscope shaft to the suturing device, rotating a suturing element with the drive shaft, moving the suturing element to grasp a suture anchor connected to the suture material, tensioning the suture material with the suturing element, aligning tissue with the suturing element, and pushing the suture anchor and suture material through the tissue.

An estimation method includes: obtaining a first voice feature group of a plurality of persons who speak a first language; obtaining a second voice feature group of a plurality of persons who speak a second language; obtaining a voice feature of a subject; correcting the voice feature of the subject according to a relationship between the first voice feature group and the second voice feature group; estimating, from the voice feature of the subject that has been corrected, an oral function or a cognitive function of the subject by using an estimation process for an oral function or a cognitive function based on the second language; and outputting a result of estimation of the oral function or the cognitive function of the subject.

An apparatus, system, and method for providing a moisture supplementation detection device. The moisture replenishment detection device includes: a flexible substrate having a circuit screen-printed therein, the circuit including a plurality of conductive ink layers and a dielectric ink layer; a sensor on the flexible substrate, wherein the sensor is capable of detecting element data indicative of a characteristic of sweat; an untreated chromatographic paper placed in contact with the skin of the user and capable of wicking sweat from the skin to the sensor along the micro-sized fluid channel; and a Bluetooth antenna on the flexible substrate and in communication with the sensor, and capable of wirelessly communicating the element data to an application capable of indicating to the user the user the suitability of moisture replenishment based on the element data.

The invention discloses a folding type clamping device, relates to the technical field of medical instruments, and is suitable for working channels of superfine endoscopes such as a breast duct endoscope. The clamping device comprises a clamping assembly, a transmission assembly, a limiting assembly and an operation assembly. The clamping assembly comprises a metal pipe body and an integrally-formed retractable net basket structure, the transmission assembly is a traction steel wire with the front end connected with the net basket structure, the limiting assembly limits the stroke of the traction steel wire through a bridge type metal pipe and a movable pin, and the operation assembly drives the traction steel wire to move. The mesh basket structure is in a closed state without external force and can be inserted into an endoscope channel; after the tissue leaves the channel, the operation assembly drives the traction steel wire to control the net basket to open and close to clamp the tissue in combination with visual observation. The device is made of medical stainless steel, is a disposable sterilized product and can be used after being disassembled. The device breaks through the sampling bottleneck of a superfine endoscope, sampling is stable and safe, early diagnosis of breast diseases is assisted, and the clinical value of the endoscope is improved.

The invention belongs to the technical field of kidney puncture, and particularly relates to kidney puncture equipment for living body examination, which comprises a crank assembly, a connecting rod assembly, a variable precision driving assembly, a lifting puncture assembly, a sampling pump, a double-shaft platform and a sliding plate, the sliding plate is arranged on the double-shaft platform, and the crank assembly and the variable precision driving assembly are arranged on the sliding plate. The connecting rod assembly is arranged between the crank assembly and the variable-precision driving assembly, the lifting puncture assembly is arranged in the middle of the sliding plate, and the sampling pump is arranged on the lifting puncture assembly. Under the condition that the precision and the speed of the driving motor are not changed, at the initial stage of descending of the hollow pipe, the relatively high puncture speed is obtained in a precision sacrificing mode, and at the tail stage of descending of the hollow pipe, the relatively high position control precision is obtained in a speed sacrificing mode.

The invention relates to the technical field of medical detection, in particular to a microneedle array-containing S100A9 sample sampling and detecting device which comprises a base, a limiting column and a color developing assembly, the limiting column is fixedly connected to the top end of the base, and a working sliding groove for inserting the color developing assembly is formed between the limiting column and the base; a sampling groove is formed in the top end of the base, the inner bottom wall of the sampling groove is fixedly connected with a microneedle assembly used for puncturing the skin of a patient for sampling, and the top of the microneedle assembly communicates with a pretreatment assembly used for filtering an extracted sample; driving force is provided for the pretreatment assembly in the process that the color developing assembly is inserted into the working sliding groove, and the filtered sample is input into the color developing assembly to be detected. According to the invention, convenient sampling is realized through the microneedle assembly, and a sample is pertinently filtered by using the pretreatment assembly, so that macromolecular interference impurities such as cell debris and hemoglobin are effectively removed, the interference on S100A9 detection is reduced, and the accuracy and reliability of S100A9 detection are improved.

The utility model relates to an angle adjusting mechanism and a biopsy device. The angle adjustment mechanism includes: a flexible tube; the first pipe comprises a first connecting part and a first pipe section, and the first connecting part is connected to the flexible pipe; the second pipe comprises a second connecting part and a second pipe section, the second pipe section is clamped to the first pipe section in the axial direction, the second pipe section is rotationally connected to the first pipe section, the rotating axis of the second pipe section is parallel to the axial direction, and the second connecting part is used for being connected with an end appliance; the control piece penetrates through the flexible pipe, the first pipe and the second pipe, the far end of the control piece is connected to the end appliance, and the control piece is used for driving the end appliance to deviate from the rotating axis relative to the second pipe. By means of the angle adjusting mechanism, the end appliance can rotate and laterally rotate in a combined mode.

The invention relates to sensing compositional information about material by measuring thermal properties of the material. In one arrangement there is provided a needle probe for sensing compositional information. The probe comprises a needle having a tip region. A resistive element is attached to the needle at the tip region. A measurement system is configured to: 1) drive an electrical current through the resistive element to apply heating to the resistive element, and 2) measure an electrical response of the resistive element to the heating. A processing unit analyses the measured electrical response of the resistive element to the heating to determine compositional information about material in contact with the tip region.

Provided is a data processing system capable of detecting that a user may have initial symptoms of dementia.　The data processing system comprises: a necklace-type terminal including a microphone that collects a user utterance of a wearer, a collection unit that collects an output of the microphone, and a communication unit that transmits the output of the microphone collected by the collection unit to an external device; and a data processing device. The data processing device includes: an input unit that receives the user utterance collected by the microphone; and a processing unit that, when a remark indicating a sign of dementia is included in the user utterance, notifies a preset notification destination that the wearer may have dementia.

The invention provides a device for collecting a nasal secretion sample. The device includes a sample collection member comprising a material for collecting a predetermined volume of a nasal secretion sample. The device further includes a handle and an elongated support member extending between the handle and the sample collection member and for supporting the sample collection member. The device is adapted for a user holding the handle to locate the sample collection member in contact with tissue at a target location inside the nasal cavity where the sample collection member collects a predetermined volume of a nasal secretion sample.