8212results about "Vaccination/ovulation diagnostics" patented technology

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir.

A bodily-fluid transfer device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.

The invention relates to the technical field of medical instrument control, in particular to a lung biopsy sampling needle stabilizing method and system based on dynamic respiration compensation. The stabilizing method comprises the following steps: acquiring a respiratory movement signal of a patient in real time through a multi-source biosensor, wherein the multi-source biosensor comprises an optical fiber strain sensor array, a diaphragm myoelectricity sensor and a respiratory airflow sensor which are deployed at the chest and abdomen. According to the method, millimeter-microsecond-level accurate and stable control over the lung biopsy sampling process is achieved by establishing a cooperation mechanism of a breathing phase-displacement nonlinear mapping model and a macro-micro composite driving framework. The biological rationality of displacement prediction is improved through deep coupling of multi-mode breathing signals, and the chest wall non-uniform deformation gradient is analyzed in space based on cross topology deployment of an optical fiber strain sensor in an intercostal space area in combination with cross-scale feature fusion of myoelectricity and airflow sensing.

The invention discloses an endoscope with a built-in grabbing mechanism, and relates to the technical field of medical instruments. According to the technical scheme, the device comprises a clamp assembly, a driving outer pipe and a driving inner wire; the grabbing mechanism further comprises a grabbing mechanism shell, a first moving seat and a second moving seat, wherein the first moving seat and the second moving seat are arranged in the grabbing mechanism shell. The near end of the driving outer tube is connected with the first moving seat, and the near end of the driving inner wire is connected with the second moving seat; when the second moving seat is fixed relative to the grabbing mechanism shell, the first moving seat moves towards the far end direction relative to the grabbing mechanism shell so as to control the clamp assembly to execute the clamping action. According to the invention, the clamping action is carried out while forward extension is carried out, so that high-precision operation is facilitated, and tissues can be accurately clamped; and moreover, the grabbing mechanism is integrated in the endoscope handle, so that accurate single-hand control is facilitated, meanwhile, the clamping action is controlled in a button mode, the human engineering is met, and operation is convenient.

A drainage system including a catheter including a sensor, a first valve in fluid communication with an interior of the catheter, a controller communicatively coupled to the sensor, the controller including logic configured to direct opening and closing of the first valve using one or both of an elapsed time and a presence of a predetermined condition, and a venturi pump in fluid communication with the interior of the catheter.

A handheld endoscope has a disposable, single-use portion that includes a distal tip, cannula, housings, and a proximal port that is connected to a substantially straight working channel. The cannula is rotatable about the main longitudinal axis of the cannula. The endoscope also includes a re-usable portion that has a handle and display module. The single-use and re-usable portions mate and un-mate with each other via physical side-mounting arrangement as well as separate electrical connectors. The handle can house imaging system electronics that support manual and auto imaging modes which can be selected via touch screen control on the display module. The re-useable portion is sealed with various o-rings and / or gaskets and can be highly fluid resistant to facilitate disinfecting and / or sterilization.

A fluid control device includes an inlet configured to be placed directly or indirectly in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device. The fluid control device has a first state in which a negative pressure differential produced from an external source such as the fluid collection device is applied to the fluid control device to draw an initial volume of bodily fluid from the bodily fluid source, through the inlet, and into a sequestration portion of the fluid control device. The fluid control device has a second state in which (1) the sequestration portion sequesters the initial volume, and (2) the negative pressure differential draws a subsequent volume of bodily fluid, being substantially free of contaminants, from the bodily fluid source, through the fluid control device, and into the fluid collection device.

Provided in the present invention is a sperm extractor with a telescopic function, including: a motor for providing power; a crank mounted on the motor; a connecting rod connected to the crank and an inner container; and the inner container for sperm extraction, where the motor rotates to drive the crank to rotate, and the crank drives the connecting rod to push or pull the inner container for sperm extraction. According to the present invention, the motor rotates to drive the crank to rotate, and the crank drives the connecting rod to push or pull the inner container to make a telescopic motion for sperm extraction; a Hall switch is further disposed on a printed circuit board (PCB) to sense positions of the crank and the connecting rod to control a stop position of the motor, so as to achieve reset.

The invention discloses a blood, urine and body fluid collecting, detecting, analyzing and uploading system based on multi-sensor integration, which comprises the following modules: a blood collecting module for collecting a blood sample; the urine collection module is used for detecting urine; the body fluid collecting module is used for detecting body fluid; the data processing module is used for preprocessing data; the feature extraction and classification module is used for constructing a multi-modal feature matrix based on a neural structure search network, a support vector machine and a random forest algorithm; the anomaly detection module is used for generating a weighted anomaly score in combination with an isolated forest and a depth anomaly detection model; the time sequence analysis module is used for analyzing the health trend by using a variational auto-encoder-generative adversarial network; the health portrait and risk assessment module is used for constructing a health map by adopting a graph convolutional network; and the encryption and uploading management module is used for encrypting by using AES and RSA and managing the data access authority based on the intelligent contract. According to the invention, a multi-modal sensor and an intelligent algorithm are integrated, and collection, detection, analysis, encryption and uploading of blood, urine and body fluid are realized.

Systems, methods, and devices feature a wearable device that includes a set of needles sized for access to interstitial fluid. The wearable device also includes a chemical indicator associated with each needle. A concentration of an analyte within the interstitial fluid can be determined based on one or more optical properties of the chemical indicator.

Systems, devices, and methods for planning an endoscopic tissue acquisition procedure for acquiring tissue from an anatomical target are disclosed. An endoscopic system comprises a steerable elongate instrument and a processor. The steerable elongate instrument can be positioned and navigated in a patient anatomy and acquire tissue from an anatomical target via a biopsy tool associated with the steerable elongate instrument. The processor can receive an image of the anatomical target, apply the received image to a trained machine-learning (ML) model to determine a tissue acquisition plan that includes a recommended biopsy tool and operational parameters for navigating the steerable elongate instrument or maneuvering the recommended biopsy tool. The tissue acquisition plan can be presented to a user, or used to facilitate a robot-assisted tissue acquisition procedure.

The invention concerns a method of monitoring (800) at least one biomarker with a measurement plan comprising a datum related to a predetermined biomarker (710) to analyze and at least one temporal analyzing window to analyze the predetermined biomarker (710). At least one of collecting (918) a urine sample and analyzing (919) the urine sample is performed at least in response to determining that an internal time value is within the at least one temporal analyzing window of the measurement plan.

Described are systems and methods for training a machine-learning model to generate image of biological samples, and systems and methods for generating enhanced images of biological samples. The method for training a machine-learning model to generate images of biological samples may include obtaining a plurality of training images comprising a training image of a first type, and a training image of a second type. The method may also include generating, based on the training image of the first type, a plurality of wavelet coefficients using the machine-learning model; generating, based on the plurality of wavelet coefficients, a synthetic image of the second type; comparing the synthetic image of the second type with the training image of the second type; and updating the machine-learning model based on the comparison.

A system for, display controller connected to, and a method of, operating a robotic catheter system which is configured to manipulate a catheter having one or more bending segments along the catheter's length and a catheter tip at the distal end thereof, and which includes an actuator unit coupled to the bending segments via one or more drive wires arranged along a wall of the catheter. The method comprising: inserting at least part of the catheter into a lumen along an insertion trajectory that spans from an insertion point to a target; causing the actuator unit to actuate at least one of the one or more drive wires to align the catheter tip with the target; determining the position and / or orientation of the catheter tip with respect to the target; and displaying information about an accuracy of alignment between the catheter tip with respect to the target.

An automated urinary output (“UO”)-measuring system includes a fluid container including a console coupled to one or more ultrasonic sensors and one or more accelerometers. The console includes a processor configured to receive accelerometer values from the one or more accelerometers, to determine an acceleration state of the fluid container, to activate the one or more ultrasonic sensors when the acceleration state of the fluid container is below a threshold, and to measure a volume of fluid in the fluid container when the acceleration state of the fluid container is zero. The system can further include a removable valve coupled to the fluid container and an attachment device including a pocket configured to accommodate the fluid container.

The invention discloses an auxiliary renal puncture device for the nephrology department, and belongs to the technical field of renal puncture, the auxiliary renal puncture device comprises a sickbed, a plurality of supporting legs are fixedly arranged at the bottom of the sickbed, fixing plates are fixedly arranged on the two sides of the sickbed, and second sliding blocks are slidably connected to one sides of the two fixing plates; the breathing frequency and amplitude of a patient are captured in real time through an infrared breathing monitoring module, and displacement data generated by breathing of the kidney are accurately obtained in combination with motion sensing modules such as a lead screw encoder and a driving gear angle encoder. The intelligent control system drives the first stepping motor and the second stepping motor to adjust the position of the portal frame based on six-dimensional force sensor data of the force sensing module, meanwhile, the angle of the puncture needle is adjusted in real time through feedback of a mechanical arm joint encoder, and dynamic compensation of kidney respiratory movement is achieved. According to the mechanism, the puncture deviation caused by breathing can be controlled within the range of + / -0.5 mm, the puncture positioning precision is remarkably improved, and poor sample quality or operation risks caused by breathing movement are avoided.

The inventions provided herein relate to injection applicators, tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.

A sensing device is used to determine the risk and / or probability of an COPD-attack and / or asthma attack of a patient. The sensing device includes a collection device for the non-invasive collection of a biological sample and a biosensor for determining the existence and / or the amount of a biomarker in the biological sample, preferably without the need for sample preparation. The device also includes a control and evaluation device that determines a risk and / or probability of an COPD and / or asthma-attack based on the existence and / or measured amount; and a measuring arrangement and a method for the maintenance of said sensing device or measurement arrangement, and an output unit that outputs the risk / probability.

The invention discloses an accurate acupuncture positioning method under ultrasonic guidance, which relates to the technical field of medical health and comprises the following steps: acquiring a two-dimensional or three-dimensional ultrasonic image of a target area by utilizing ultrasonic image acquisition equipment; the Young modulus of the target area is calculated by measuring the shear wave propagation speed of the tissue of the target area; a sensor module is adopted to monitor the interaction force between the puncture needle and the tissue in real time, and mechanical data are obtained; according to Young modulus and modulus variance obtained through calculation of the shear wave elastography image and mechanical data fed back by a sensor, a time sequence feature vector is constructed; performing dynamic modeling and prediction on the tissue state in the puncture process by using a long-short-term memory neural network; the path offset of the needle head is judged, a correction signal is generated through a PID controller, and the posture or direction of the needle head is adjusted in real time; the problem of artifacts in a traditional ultrasonic image can be solved, more accurate acupuncture path planning is provided, and the method adapts to the change of tissue elasticity in real time.

A needle guide for an angled ultrasound probe having a port tower with a plurality of needle ports aligned with an angled ultrasonic imaging plane. The needle ports in a port tower are aligned at the offset angle of the angled ultrasound probe and can support and guide a needle at the offset angle. Adjustment of the port tower along the transducer axis of the angled ultrasound probe maintains the alignment of the needle ports relative to the ultrasonic imaging plane and provides adjustment to accommodate differently sized patients. A method is also provided to securely align a needle with an angled ultrasonic imaging plane with an angled ultrasound probe such that the needle can accurately transect the ultrasound imaging plane.

Apparatuses and methods for recovering solid tissue and dislodged cells (“D-cells”) from a biopsy are disclosed herein. In an embodiment, a biopsy container apparatus for recovering solid tissue and D-cells from a biopsy includes a receiving container and a sieve container. The receiving container has a receiving chamber with an upper opening and a watertight bottom surface. The sieve container is configured to be located at least partially within the receiving chamber and removed from the receiving chamber through the upper opening. The sieve container has a bottom sieve surface including a plurality of apertures configured to pass the D-cells from the biopsy but not the solid tissue from the biopsy into the receiving chamber after the solid tissue and the D-cells from the biopsy are placed into the sieve container.

Urine collection systems and associated methods and devices are disclosed herein. A representative system can include a urine collection device, a flow control assembly configured to direct a urine flow from the patient to the urine collection device, and a urine measurement device including a first sensor and a second sensor. The first sensor is configured to generate first sensor data based on a weight of the container, and the second sensor is configured to generate second sensor data based on the urine flow from the patient to the container. The system can further include non-transitory computer readable media having instructions that, when executed by one or more processors, cause the system to perform operations comprising determining a first patient urine output based on the first sensor data; and determining a second patient urine output based on the second sensor data.

The invention relates to the technical field of chronic kidney disease screening, and discloses an intelligent chronic kidney disease early screening instrument which comprises a physiological parameter detection module configured to synchronously collect multi-dimensional bio-electricity signals, optical characteristic parameters and body fluid biochemical parameters of a subject and output original signals; the multi-modal data processing module is in communication connection with the physiological parameter detection module and is configured to receive original signals, perform time domain and frequency domain conjoint analysis and construct a parameter incidence matrix; the wireless communication module is configured to realize encrypted interaction between the screening data and the cloud server and block chain evidence storage; and the man-machine interaction module is configured to display the risk level map in real time. According to the method, holographic dynamic correlation modeling of kidney function related micro-electrophysiological fluctuation and optical metabolism characteristics is realized, and a specific cross-modal pathological correlation mode of early renal injury can be effectively identified based on a time-frequency domain combined characteristic extraction and dynamic coupling algorithm.

A tissue resection apparatus is provided which includes an outer tube with a helical coil disposed on a distal end. The coil is provided with a first electrode. A central tube has a distal edge profile comprising one or more surface segments. One of the surface segments includes a second electrode. The central tube is slidably disposed within the outer tube and positioned such that second electrode opposes at least a portion of the first electrode. A cutting tube is slidably disposed within the central tube and includes a cutting edge.

Described are systems and methods for training a machine-learning model to generate image of biological samples, and systems and methods for generating enhanced images of biological samples. The method for training a machine-learning model to generate images of biological samples may include obtaining a plurality of training images comprising a training image of a first type, and a training image of a second type. The method may also include generating, based on the training image of the first type, a plurality of wavelet coefficients using the machine-learning model; generating, based on the plurality of wavelet coefficients, a synthetic image of the second type; comparing the synthetic image of the second type with the training image of the second type; and updating the machine-learning model based on the comparison.

The sampling detection device comprises a sampling tube, a cylindrical block, a threaded sleeve rod, an air bag and a sealing mechanism, the sampling tube is inserted into the vagina of a patient, the cylindrical block is horizontally and movably connected to the inner wall of one end of the sampling tube, the threaded sleeve rod is rotatably connected to the inner wall of the cylindrical block, and the air bag is fixedly connected to the outer contour of the end, away from the cylindrical block, of the sampling tube; the sampling tube is used for supporting the inner wall of the vagina, the sampling tube is provided with a vent hole for inflating to control the air bag, the cylindrical block is provided with a cavity, the inner wall of the cylindrical block is movably connected with a locking block to lock and unlock the threaded sleeve rod, and the sampling tube is further provided with a sealing mechanism, so that the sealing performance of a sample in the transportation and storage process is ensured, and pollution is avoided; the inner wall of the vagina is supported by the air bag, so that the sampling safety and comfort are improved; through a multi-point sampling mechanism, the representativeness of the sample is enhanced; and through the sealing mechanism, the stability and the purity of the sample are guaranteed, so that the accuracy and the efficiency of gynecological secretion detection are improved.

A mask-based diagnostic apparatus is provided for detecting a biomarker contained in exhaled breath of a test subject. An exhaled breath condensate (EBC) collector converts breath vapor received from the lungs and airways of the test subject into a fluid biosample. The EBC collector including a thermal mass, a condensate-forming surface and a fluid conductor disposed on the condensate-forming surface. A fluid transfer system receives the fluid biosample from the EBC collector. A biomarker testing unit receives the fluid biosample from the fluid transfer system and tests the fluid biosample for a target biomarker. A testing system support is provided for supporting the EBC collector, the fluid transfer system and the biomarker testing unit. The testing system support is configured and dimensioned to fit inside a face mask. A face mask is provided forming an exhaled breath vapor containment volume to hold the exhaled breath vapor in proximity to the EBC collector to enable the condensate-forming surface cooled by the thermal mass to coalesce the exhaled breath vapor into the fluid biosample.

A biosensor cartridge can include a circuit board having a connection terminal configured to be electrically connected to an external diagnostic device, a biosensor chip configured to detect a target material from an analysis specimen, and transmit an electrical signal to the connection terminal of the circuit board based on the target material being present in the analysis specimen, the biosensor chip including a reactant configured to react specifically with the target material, and a housing enclosing the circuit board and the biosensor chip, and the connecting terminal being exposed outside of the housing. Also, the biosensor chip includes a plurality of channel areas separated from each other, and the reactant is attached to the plurality of channel areas.

A specimen collection, storage, transport, and testing device can include a vessel carrying a liquid reagent. A lid sealing the vessel can include a solid specimen collection stick projecting from an inside surface of the lid. Further, the lid can include a port on its outside surface. The port can be releasably engaged by a hand-manipulable handle facilitating specimen collection and attachment of the lid to the vessel. The port can further include an openably sealed aperture for accommodating the insertion of a test strip-carrying cartridge. The reusability of the handle and its reduced material structure helps avoid waste.