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3797results about "Infusion syringes" patented technology

Vascular valves and servovalves - and prosthetic disorder response systems

PendingUS20250242099A1Urinary bladderOther blood circulation devicesBlood flowUrine catheter
Set forth are vascular valves and servovalves and methods of using the same that may be positioned in the circulatory system without interrupting blood flow to facilitate solid organ transplantation so as to reduce graft organ anoxia and degradation before and after harvesting and storage, thereby minimizing late-term cardiac allograft vasculopathy as a major cause of graft failure. Along the urinary tract, bypassing bladder-generated urge sensation by diverting urine directly from the ureters to a neobladder or collection bag alleviates intractable incontinence, nocturia, urethral syndrome, overactive bladder, dysuria, or frequency. Where the lower tract is missing, a prosthesis can thwart disease and preclude the degenerative metaplastic transition to carcinoma risked when gut is used to construct a conduit for urine, a neobladder, and / or high-maintenance stoma. Druglines to valves and servovalves can directly pipeline-target medication to nidi, anastomoses, or any other trouble spots.
Owner:GOLDSMITH DAVID S

Rapidly Insertable Central Catheters Including Catheter Assemblies and Methods Thereof

PendingUS20250082906A1Guide needlesMulti-lumen catheter
Rapidly insertable central catheters (“RICCs”) including catheter assemblies and methods thereof are disclosed. A RICC assembly can include a RICC, an introducer, and a coupling system configured to couple the RICC and the introducer together. A catheter tube of the RICC includes a side aperture in a distal-end portion of the catheter tube, which opens into an introducing lumen extending to a distal end of the RICC. The introducer includes an introducer needle extending through the distal end of the RICC when the RICC assembly is in at least a ready-to-deploy state thereof. The introducer is configured to be actuated with a single finger of a hand while holding a distal-end portion of the introducer between a thumb and another finger or fingers of the hand. The coupling system includes a distal coupler slidably attached to the catheter tube proximal of the side aperture.
Owner:BARD ACCESS SYSTEMS INC

Antiseptic cap

PendingUS20250099686A1Infusion syringesMedical devices
A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap holder assembly containing a cap and an absorbent material removably attached to the syringe.
Owner:EXCELSIOR MEDICAL CORP

Tamper evident seal for a vial cover

A tamper evident seal structure for a vial septum or other cover having a housing including a sidewall terminating in oppositely disposed open and closed ends. A retainer is fixedly disposed within the housing and structured for retaining engagement with a portion of a vial, substantially adjacent the vial cover. The housing also includes a pressure member disposed within an interior thereof in attached, relation to the closed-end. The pressure member and the retainer are cooperatively disposed and structured to respectively exert pressure on the vial cover concurrent to retaining engagement with the vial. Tamper evident capabilities are at least partially defined by a detachment of a removable sidewall section from a remainder of said sidewall.
Owner:MEDICAL DEVICE ENGINEERING LLC

Multi-fluid delivery system

A fluid delivery system is disclosed which comprises at least one first supply station for supplying a first fluid and at least one second supply station for supplying a second fluid different from the first fluid. The fluid delivery system further comprises a pressurizing unit for pressurizing the first and second fluids, said pressurizing unit comprising first and second pump modules, and each pump module comprising a chamber and a piston provided with a plunger to define first and second variable-volume sub-chambers. The fluid delivery system further comprises first and second inlet fluid circuits, first and second outlet fluid circuits, and a first recirculation fluid pathway fluidically connecting the first and second variable-volume sub-chambers of a pump module. Moreover, a first actuator is associated to said first recirculation fluid pathway for managing the fluid passage in both directions between said first and second variable-volume sub-chambers of said pump module. Methods of operating the fluid delivery system are disclosed too.
Owner:ACIST MEDICAL SYSTEMS INC

Automatic locking and unlocking vacuum syringes, and associated systems and methods

PCT designated stage expiredWO2025106851A1Infusion syringesSurgeryPlungerPhysics
Disclosed herein are automatic-locking and automatic-unlocking syringes, and associated systems and methods. In some embodiments, a syringe can include a barrel, a plunger assembly slidably positioned within the barrel, and a locking assembly coupled to the barrel. The syringe is configured to (i) automatically lock the plunger assembly to the locking assembly when the plunger assembly is withdrawn through the barrel with a vacuum in the barrel, (ii) automatically unlock the plunger assembly from the locking assembly when the barrel no longer experiences vacuum and / or experiences negligible vacuum, and / or (iii) inhibit or even prevent automatic locking of the plunger assembly to the locking assembly when the plunger assembly is withdrawn through the barrel with no and / or negligible vacuum within the barrel.
Owner:INARI MEDICAL INC +1

Feedback optimization type injection pen

The invention discloses a feedback optimization type injection pen, and relates to the technical field of medical instruments, a push rod nut is arranged on a pen body, and the push rod nut is provided with an elastic cantilever; the injection mechanism comprises a push rod sleeve and a push rod, when the push rod sleeve rotates relative to the pen body, the axial position is positioned through a push rod nut, the push rod sleeve is provided with a one-way fluted disc, and the one-way fluted disc makes contact with the elastic cantilever, limits one-way rotation of the push rod sleeve and feeds back sound during rotation. The push rod is arranged in the push rod sleeve, is in threaded connection with the push rod nut, is driven by the push rod sleeve to rotate and moves under the action of threads of the push rod nut so as to push and inject liquid medicine in the clamping type bottle. According to the feedback optimization type injection pen, the one-way fluted disc is arranged on the push rod sleeve and makes contact with the elastic cantilever, one-way rotation of the push rod sleeve is limited, sound is fed back during rotation, the problem that injection feedback of an existing injection pen is not accurate enough is effectively solved, and the accuracy and reliability of injection dosage are improved.
Owner:SHANDONG WEGO PREFILLS PHARM PACKAGING CO LTD

Separating hashing from proof-of-work in blockchain environments

Blockchain environments may mix-and-match different encryption, difficulty, and / or proof-of-work schemes when mining blockchain transactions. Each encryption, difficulty, and / or proof-of-work scheme may be separate, stand-alone programs, files, or third-party services. Blockchain miners may be agnostic to a particular coin's or network's encryption, difficulty, and / or proof-of-work schemes, thus allowing any blockchain miner to process or mine data in multiple blockchains. GPUs, ASICs, and other specialized processing hardware components may be deterred by forcing cache misses, cache latencies, and processor stalls. Hashing, difficulty, and / or proof-of-work schemes require less programming code, consume less storage space / usage in bytes, and execute faster. Blockchain mining schemes may further randomize byte or memory block access, further improve cryptographic security.
Owner:INVENIAM CAPITAL PARTNERS INC

Device for delivering an antimicrobial composition into a medical device

A male cap can include a male tapered outer surface that can be configured to mate with a female luer to create a fluid tight fit. The male cap can also include a water-soluble antimicrobial composition disposed on the male extension. The male cap can include a fluid-soluble, slower-dissolving material covering the water-soluble antimicrobial composition or incorporated within the water-soluble antimicrobial composition. The slower-dissolving material can be configured to slow a dissolution of the water-soluble antimicrobial composition during installation of the male cap into the female luer.
Owner:ICU MEDICAL INC

Injection pen assembly and injection pen

The invention belongs to the technical field of injection pens, and particularly relates to an injection pen assembly. The upper pen body is connected with the end cover; the support is located in the upper pen body, the near end of the support is connected with an end cover, a limiting sliding groove is formed in the side wall of the support, and the far end of the limiting sliding groove extends to form an excitation sliding groove and a locking sliding groove; the push rod sleeve is arranged on the outer side of the support in a sleeving mode, a sliding block is arranged on the inner wall of the push rod sleeve, and the sliding block is clamped in the excitation sliding groove before the injection pen is excited; the push rod sleeve is driven by the excitation sleeve to slide towards the near end, the limiting sliding groove is formed in the side wall of the support, and the excitation sliding groove and the locking sliding groove extend from the far end of the limiting sliding groove, so that when the push rod sleeve slides towards the near end, the sliding block slides into the limiting sliding groove, and after injection is completed, the sliding block slides into the locking sliding groove. And the push rod sleeve is stopped by a locking surface in the locking chute, so that the needle head is prevented from being exposed due to the fact that the push rod sleeve slides towards the near end again.
Owner:JIANGSU WANHAI MEDICAL INSTR CO LTD

Special injection pen for preventing acupuncture injury of insulin

The invention provides an injection pen special for preventing acupuncture injury of insulin, and relates to the technical field of medical instruments, the injection pen comprises an injection pen body, the outer circumference of the injection pen body is provided with a metering observation window, the rear end face of the injection pen body is provided with an injection push key, and the front end face of the injection pen body is provided with a piston rod. The injection needle is sleeved with the inner needle cap and the outer needle cap, multiple protections are formed, it is ensured that the injection needle is properly protected in the transportation, storage and use processes, the probability of pricking injury is greatly reduced, the rubber column is fixedly installed at the front end of the outer needle cap, for old people with poor eyesight, a needle head can be inserted into the rubber column, and the rubber column is fixedly installed at the front end of the outer needle cap. The needle head can be hidden, and the problems that old people with poor eyesight are difficult to read metering scales, and a replaced injection needle is prone to hurting a user and other people are solved.
Owner:CHENGDU MILITARY GENERAL HOSPITAL OF PLA

Disposable injection pen

The disposable injection pen comprises an upper pen shell assembly and a lower pen shell assembly which are assembled and matched, the lower pen shell assembly comprises a pen cap and a protective shell clamped in the pen cap, and a bracket for supporting a pre-filled syringe is arranged on the inner ring of the protective shell; a pen cap spring extending towards the bracket is arranged on the pen cap; and the pen cap spring is in pressing fit with the axial edge of the needle protecting cap. According to the lower pen shell assembly, a protective shell installed in a pen cap lifts and supports a bracket, a pre-filled syringe can be fixedly installed in the bracket, a pen cap spring is arranged in the pen cap, the axial edge of a needle protecting cap is pressed and matched through the pen cap spring, the pen cap of a spring structure is arranged, the spring is pressed on the circumferential edge of the needle protecting cap, and therefore the pre-filled syringe can be fixed to the bracket. Therefore, the needle protecting cap is subjected to axial pulling-out acting force, the clamping structure is stable, and smooth pulling out of the needle protecting cap is guaranteed.
Owner:SUZHOU JIASHU MEDICAL TECH CO LTD

Double-cavity pre-filling and sealing injector with equal-diameter channels and pre-filling and sealing method

According to the double-cavity prefilled syringe with the equal-diameter channels and the prefilling method, firstly, a middle piston is installed through mechanical plugging, then sterile powder in a first medicament cavity is filled, and after a rubber gasket, a Luer lock adapter and a protective cap assembly are assembled, sterile powder is filled in the first medicament cavity in a pressing mode; the Ruhr lock adapter annular buckle is guided by the auxiliary conical surface to be fixed to the limiting groove, at the moment, the rubber gasket is pressed by the mechanical sealing structure, meanwhile, the protective cap assembly seals the Ruhr lock medicine outlet, and a cavity close to the medicine outlet is well sealed. Then the double-cavity pre-filling syringe is turned over, the solvent is filled from a flange inlet, filling of the second medicament cavity is completed, a push rod piston is installed through mechanical plug adding, and a cavity far away from a medicament outlet is well sealed. According to the invention, the two ends of the needle cylinder are adopted to realize pre-encapsulation administration, so that the administration residue or pollution can be avoided, and the rubber gasket, the Luer lock adapter and the protective cap assembly are matched to realize high-precision sealing.
Owner:NANJING BATFREY PHARM PACKAGING MATERIALS CO LTD

SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS

A vessel including a thermoplastic wall enclosing a lumen is disclosed. The wall supports an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, between the wall and the lumen. High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the wall or substrate. In one aspect, the interface has at least 1 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding. In another aspect, the interface has an Si 2p chemical shift to lower binding energy (eV), compared to the binding energy of SiO4 bonding. The result is a tightly adherent composite barrier coating or layer having a high degree of adhesion to the substrate under practical use conditions. Methods of applying the composite barrier coating or layer are also disclosed.
Owner:SIO2 MEDICAL PRODUCTS INC

Liquid pushing stable type injection pen and working method thereof

ActiveCN119950893AInfusion syringes
The invention belongs to the technical field of instruments for inputting a medium into a human body or onto the human body, and particularly relates to a liquid pushing stable type injection pen and a working method of the liquid pushing stable type injection pen. The driving mechanism is arranged in the shell and comprises a lead screw and a push block, and the push block is rotationally arranged at the clamping end of the lead screw through a clamping cavity in the push block; the retaining mechanism is arranged at the clamping end of the lead screw, and the retaining mechanism extends outwards and abuts against the inner wall of the clamping cavity so as to maintain the stability of the push block; according to the liquid pushing stable type injection pen and the working method thereof, the retaining mechanism is arranged at the clamping end of the lead screw, when medicine injection is stopped, the lead screw rotates to move downwards to abut against the pushing block and then pushes the pushing block to move synchronously, and meanwhile the retaining mechanism retracts after being stressed to relieve limiting. And the maintaining mechanism extends outwards and abuts against the inner wall of the clamping cavity, so that the push block is tensioned at the clamping end of the lead screw, namely, the stability of the push block is maintained, and the push block is prevented from shaking.
Owner:JIANGSU WANHAI MEDICAL INSTR CO LTD

Syringe

The utility model belongs to the technical field of medical instruments, and particularly provides an injector which comprises a shell assembly, a memory mechanism and an injection mechanism, the memory mechanism comprises a memory sleeve and a memory ring, the memory ring is arranged on the memory sleeve in a threaded and sleeving mode, and when the memory ring abuts against a stop structure of the memory sleeve, the memory sleeve is sleeved with the memory ring. The memory ring is limited to rotate in the first hour hand direction relative to the memory sleeve; the injection mechanism comprises a push rod and a one-way limiting assembly; when a medicine bottle is contained in the containing space of the shell assembly, the push rod is limited to rotate in the first hour hand direction relative to the shell assembly. When the medicine bottle is not contained in the containing space, the push rod can rotate in the first hour hand direction relative to the shell assembly, then the memory sleeve is linked to rotate in the first hour hand direction relative to the memory ring, and the push rod and the memory ring are reset at the same time. The syringe provided by the embodiment of the utility model not only has a reusable function, but also can ensure that the dosage set at the last time is equal to the dosage actually injected at the last time.
Owner:GANGAN MEDICAL TECH JIANGSU CO LTD

Operating a portable medical device

Some embodiments of a portable medical device, such as an infusion pump, can receive an external reference signal (e.g., a radio, cellular and / or satellite signal) to provide an automatic time-setting and maintenance operation. In these circumstances, the medical device can maintain accurate time and date information even in the event of a power interruption, a time-zone change and / or an internal clock error, for example. In this manner, the portable medical device provides safe operation and added convenience to the user.
Owner:INSULET CORP

Sound feedback structure at end of injection of injection pen

The invention provides a sound feedback structure at the end of injection of an injection pen, which comprises a shell and a movable dose display element, and the shell is divided into a near end and a far end; a fixing assembly is arranged at the far-body end of the shell, and the dose display element is connected with the shell through a threaded structure and moves in the axial direction to indicate the dose during injection; when the injection is finished, the dose display element and the fixing component interact to generate mechanical impact sound to prompt the user that the operation is finished; the mechanical impact sound is achieved through deformation energy storage and release of the elastic component, and the volume of the impact sound can be adjusted through the deformation distance.
Owner:SUZHOU SENBOMED MEDICAL TECHNOLOGY LTD

Syringes configured to inhibit forward plunger movement

Disclosed are systems that include a syringe having a barrel configured to hold a fluid and a plunger configured to draw the fluid into the barrel when the plunger is pulled backward through the barrel. The syringe is configured to inhibit forward movement of the plunger. For example, the systems can include mating pockets configured to engage barbs to inhibit forward movement of the plunger.
Owner:KURIN INC

Hydrolysis-resistant hydrogels and methods of treatment using same

In some aspects, the present disclosure provides systems for forming hydrogels that comprise (i) a reactive multi-arm polymer that comprises three or more polymer arms linked to a core region, each arm comprising a polyether segment and a reactive moiety comprising a cyclic imide carboxy-C1-C5-alkyl ester end group or each arm comprising a polyether segment and a reactive moiety comprising a C2-C6-isocyanoalkyl end group and (ii) a polyamino compound comprising at least two amino (-NH2) groups, wherein the reactive multi-arm polymer and the polyamino compound react to form a crosslinked hydrogel that does not contain ester groups and has long-term stability in vivo. In some aspects, the present disclosure provides methods of treatment using such systems and hydrolysis-resistant crosslinked hydrogels formed from such systems.
Owner:BOSTON SCIENTIFIC SCIMED INC

Contrast agent injection regulation and control device

The invention discloses a contrast agent injection regulation and control device, and relates to the technical field of contrast agent injection.The contrast agent injection regulation and control device comprises an injection pipe, one end of the injection pipe is fixedly connected with a limiting plate, a piston is slidably installed in the injection pipe, a drawing rod is installed on one side of the piston, and one end of the drawing rod is fixedly connected with a pushing piece; a limiting ring is fixedly connected to the outer portion of the drawing rod, first limiting grooves are symmetrically formed in the outer portion of the injection pipe, and an adjusting mechanism is arranged on the outer portion of the injection pipe. The position of the positioning mechanism can be changed by moving the adjusting mechanism, the scale strip is arranged outside the injection tube, the adjusting mechanism can be conveniently moved to a proper position, and when a contrast agent is sucked, due to the cooperation of the positioning mechanism and the limiting ring, the drawing rod can only move to a designated position, so that the amount of the sucked contrast agent is guaranteed, and the contrast agent suction efficiency is improved. The situation that the subsequent radiography effect is affected after too much or too little inhalation is injected into the body of a patient is avoided, and adjustment can be conveniently conducted according to the condition of the patient.
Owner:深圳市龙华区中心医院

Disposable adjustable injection pen

The utility model provides a disposable adjustable injection pen, comprising a medicine bin, an injection mechanism, and a pen cap. The injection mechanism comprises: a pen barrel, a scale sleeve, a pressing head, a transmission rotating cylinder, an engaging transmission block, and a screw rod. The transmission rotating cylinder is arranged in the scale sleeve, and a transmission member that cooperates with the transmission part is arranged between the transmission rotating cylinder and the scale sleeve. The engaging transmission block is connected and fixed to the pen barrel, and the engaging transmission block is provided with a threaded hole that penetrates the body; the screw rod is threadedly connected in the threaded hole of the engaging transmission block and one end of the screw rod extends into the medicine bin, and a directional transmission sleeve that is movable in the rotation direction and axial direction is connected to the screw rod, and the screw rod can move axially relative to the directional transmission sleeve, and one end of the directional transmission sleeve is movably clamped in the engaging transmission block or the pen barrel or between the engaging transmission block and the pen barrel; compared with the prior art, the utility model has a relatively simple structure and lower cost, and has smaller resistance to exciting the injection button and smaller pushing resistance during injection.
Owner:孙振宇

Communication tag for a drug product

A medication delivery device is provided having a housing comprising a reservoir sized sufficiently to hold medication, an actuating button for initiating an injection of the medication, and a label affixed on at least a portion of the housing. The label comprises a communication tag configured to, when accessed by a mobile device, cause the mobile device to launch a web browser configured to access a uniform resource locator (URL). The mobile device is configured to receive data from a communication tag disposed on the medication delivery device and verify and / or authenticate an aspect of the medication delivery device or track possession of the medication delivery device based on the received data.
Owner:ELI LILLY & CO

Reuse prevention injection device

A disposable injection device may include a syringe barrel having a cylinder-shaped internal structure; a plunger rod which is coupled to the syringe barrel and movably disposed to make a sliding reciprocating motion to inject a medicine contained inside; and an adaptor which is coupled to an upper end portion of the syringe barrel to prevent separation of the plunger rod coupled to the syringe barrel, wherein when the plunger rod moves toward a syringe needle coupled to a lower end of the syringe barrel, a locking flange protruding in a radial direction of the plunger rod is inserted into a flange locking hole passing through the adaptor, and subsequently when the plunger rod is pulled in a rearward direction, the locking flange is fit into the flange locking hole to restrain movements in the rearward direction, thereby preventing syringe reuse.
Owner:POONGLIM PHARMATECH

Dose adjusting mechanism of injection device and injection device

The invention relates to the technical field of medical instruments, in particular to a dose adjusting mechanism of an injection device and the injection device. A push rod part penetrates through a holding part and is in threaded connection with the holding part, a sound tooth part sleeves the push rod part and is in circumferential limiting connection with the push rod part, and the push rod part can move in the axial direction relative to the sound tooth part; one-way clamping grooves distributed in the circumferential direction are formed in the circumferential wall defining the containing cavity, the sound tooth part is located in the containing cavity, the sound tooth part is provided with an elastic clamping part, and the elastic clamping part is clamped into any one of the one-way clamping grooves; under the state that the push rod part is pressed, the push rod part can move in the axial direction and drive the sound tooth part to rotate synchronously under the action of the threads, so that the elastic clamping part slides along the peripheral wall defining the containing cavity to be clamped into one of the one-way clamping grooves in the front end. Axial control of the push rod part is converted into rotation control of the sound tooth part, rotation movement of the sound tooth part is discretized into fixed angle grading, the axial displacement of single-time grading of the push rod part is extremely small, and the small-dose injection requirement is met.
Owner:SUZHOU JIASHU MEDICAL TECH CO LTD

Syringe

The invention relates to the field of medical equipment, and discloses an injector which comprises a barrel and a piston rod, a groove is formed in the top end of the barrel, a first gear is arranged in the groove, the outer wall of the first gear is in meshed connection with a second gear, the second gear is connected with a transmission rod, and the other end of the transmission rod is connected with a driving structure. The driving structure is arranged at the end, away from the end of the piston rod, of the barrel and drives the first gear to rotate around the axis of the barrel through the second gear. The inner wall of the first gear is in threaded connection with the piston rod to drive the piston rod to move in the barrel; the second gear can be driven to rotate through the driving structure, and then the first gear is driven to rotate, so that the piston rod is driven to move in the barrel, injection is completed, the piston rod does not need to be directly pushed, the injector is more convenient and faster to use, more labor is saved, and the injection efficiency is higher; and the position of the injector in the injection process is more stable, and the injection safety is higher.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV

Display method for medical device, and medical system and medical device

A display method for a medical device, a medical system and a medical device are disclosed. The method includes acquiring medical data of a medical object related to one or more physiological parameters of the medical object; acquiring data for a control parameter of a treatment device for providing treatment for the medical object, wherein the treatment device provides the treatment for the medical object based on the control parameter, so as to affect the medical data; determining a grouping of the physiological parameter(s) and the control parameter, wherein each group includes at least one physiological parameter and at least one control parameter which is capable of affecting said physiological parameter, and associatively displaying the medical data which is related to the physiological parameter(s) and an operation interface for adjusting the control parameter, which parameters are in a same group. Such that working efficiency of medical staff is improved.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY +1

Positive and negative rotation adjusting mechanism for injector and injection pen

The invention belongs to the technical field of injectors, and particularly relates to a forward and reverse rotation adjusting mechanism for an injector and an injection pen. The forward and reverse rotation adjusting mechanism for the injector comprises a rotary drum gear, and ratchets are arranged on the end wall of the rotary drum gear; the dosage knob is rotationally arranged at the end part of the pen body; the push rod rotating cylinder and the rotating cylinder gear are coaxially arranged, and the push rod rotating cylinder is suitable for axially moving relative to the pen body; the drum upper gear is arranged in the dosage knob, sleeves the outer wall of the push rod drum and is meshed with the drum gear; when the dosage knob rotates in the forward direction, the gear on the rotary drum is driven to rotate in the forward direction relative to the rotary drum gear so as to pressurize the coil spring in the pen body. When the dosage knob rotates reversely, the drum upper gear is pushed by the dosage knob to move in the direction away from the drum gear and is disengaged from the ratchet, so that the drum upper gear rotates reversely relative to the drum gear; through cooperation of the drum gear, the drum upper gear and the dosage knob, forward and reverse rotation adjustment of the drum gear is achieved, and the size of the interior of the pen body is reduced.
Owner:JIANGSU WANHAI MEDICAL INSTR CO LTD