2673results about "Infusion syringes" patented technology

Set forth are vascular valves and servovalves and methods of using the same that may be positioned in the circulatory system without interrupting blood flow to facilitate solid organ transplantation so as to reduce graft organ anoxia and degradation before and after harvesting and storage, thereby minimizing late-term cardiac allograft vasculopathy as a major cause of graft failure. Along the urinary tract, bypassing bladder-generated urge sensation by diverting urine directly from the ureters to a neobladder or collection bag alleviates intractable incontinence, nocturia, urethral syndrome, overactive bladder, dysuria, or frequency. Where the lower tract is missing, a prosthesis can thwart disease and preclude the degenerative metaplastic transition to carcinoma risked when gut is used to construct a conduit for urine, a neobladder, and / or high-maintenance stoma. Druglines to valves and servovalves can directly pipeline-target medication to nidi, anastomoses, or any other trouble spots.

A tamper evident seal structure for a vial septum or other cover having a housing including a sidewall terminating in oppositely disposed open and closed ends. A retainer is fixedly disposed within the housing and structured for retaining engagement with a portion of a vial, substantially adjacent the vial cover. The housing also includes a pressure member disposed within an interior thereof in attached, relation to the closed-end. The pressure member and the retainer are cooperatively disposed and structured to respectively exert pressure on the vial cover concurrent to retaining engagement with the vial. Tamper evident capabilities are at least partially defined by a detachment of a removable sidewall section from a remainder of said sidewall.

A fluid delivery system is disclosed which comprises at least one first supply station for supplying a first fluid and at least one second supply station for supplying a second fluid different from the first fluid. The fluid delivery system further comprises a pressurizing unit for pressurizing the first and second fluids, said pressurizing unit comprising first and second pump modules, and each pump module comprising a chamber and a piston provided with a plunger to define first and second variable-volume sub-chambers. The fluid delivery system further comprises first and second inlet fluid circuits, first and second outlet fluid circuits, and a first recirculation fluid pathway fluidically connecting the first and second variable-volume sub-chambers of a pump module. Moreover, a first actuator is associated to said first recirculation fluid pathway for managing the fluid passage in both directions between said first and second variable-volume sub-chambers of said pump module. Methods of operating the fluid delivery system are disclosed too.

A male cap can include a male tapered outer surface that can be configured to mate with a female luer to create a fluid tight fit. The male cap can also include a water-soluble antimicrobial composition disposed on the male extension. The male cap can include a fluid-soluble, slower-dissolving material covering the water-soluble antimicrobial composition or incorporated within the water-soluble antimicrobial composition. The slower-dissolving material can be configured to slow a dissolution of the water-soluble antimicrobial composition during installation of the male cap into the female luer.

The invention belongs to the technical field of injection pens, and particularly relates to an injection pen assembly. The upper pen body is connected with the end cover; the support is located in the upper pen body, the near end of the support is connected with an end cover, a limiting sliding groove is formed in the side wall of the support, and the far end of the limiting sliding groove extends to form an excitation sliding groove and a locking sliding groove; the push rod sleeve is arranged on the outer side of the support in a sleeving mode, a sliding block is arranged on the inner wall of the push rod sleeve, and the sliding block is clamped in the excitation sliding groove before the injection pen is excited; the push rod sleeve is driven by the excitation sleeve to slide towards the near end, the limiting sliding groove is formed in the side wall of the support, and the excitation sliding groove and the locking sliding groove extend from the far end of the limiting sliding groove, so that when the push rod sleeve slides towards the near end, the sliding block slides into the limiting sliding groove, and after injection is completed, the sliding block slides into the locking sliding groove. And the push rod sleeve is stopped by a locking surface in the locking chute, so that the needle head is prevented from being exposed due to the fact that the push rod sleeve slides towards the near end again.

The disposable injection pen comprises an upper pen shell assembly and a lower pen shell assembly which are assembled and matched, the lower pen shell assembly comprises a pen cap and a protective shell clamped in the pen cap, and a bracket for supporting a pre-filled syringe is arranged on the inner ring of the protective shell; a pen cap spring extending towards the bracket is arranged on the pen cap; and the pen cap spring is in pressing fit with the axial edge of the needle protecting cap. According to the lower pen shell assembly, a protective shell installed in a pen cap lifts and supports a bracket, a pre-filled syringe can be fixedly installed in the bracket, a pen cap spring is arranged in the pen cap, the axial edge of a needle protecting cap is pressed and matched through the pen cap spring, the pen cap of a spring structure is arranged, the spring is pressed on the circumferential edge of the needle protecting cap, and therefore the pre-filled syringe can be fixed to the bracket. Therefore, the needle protecting cap is subjected to axial pulling-out acting force, the clamping structure is stable, and smooth pulling out of the needle protecting cap is guaranteed.

A vessel including a thermoplastic wall enclosing a lumen is disclosed. The wall supports an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, between the wall and the lumen. High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the wall or substrate. In one aspect, the interface has at least 1 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding. In another aspect, the interface has an Si 2p chemical shift to lower binding energy (eV), compared to the binding energy of SiO4 bonding. The result is a tightly adherent composite barrier coating or layer having a high degree of adhesion to the substrate under practical use conditions. Methods of applying the composite barrier coating or layer are also disclosed.

Some embodiments of a portable medical device, such as an infusion pump, can receive an external reference signal (e.g., a radio, cellular and / or satellite signal) to provide an automatic time-setting and maintenance operation. In these circumstances, the medical device can maintain accurate time and date information even in the event of a power interruption, a time-zone change and / or an internal clock error, for example. In this manner, the portable medical device provides safe operation and added convenience to the user.

Disclosed are systems that include a syringe having a barrel configured to hold a fluid and a plunger configured to draw the fluid into the barrel when the plunger is pulled backward through the barrel. The syringe is configured to inhibit forward movement of the plunger. For example, the systems can include mating pockets configured to engage barbs to inhibit forward movement of the plunger.

In some aspects, the present disclosure provides systems for forming hydrogels that comprise (i) a reactive multi-arm polymer that comprises three or more polymer arms linked to a core region, each arm comprising a polyether segment and a reactive moiety comprising a cyclic imide carboxy-C1-C5-alkyl ester end group or each arm comprising a polyether segment and a reactive moiety comprising a C2-C6-isocyanoalkyl end group and (ii) a polyamino compound comprising at least two amino (-NH2) groups, wherein the reactive multi-arm polymer and the polyamino compound react to form a crosslinked hydrogel that does not contain ester groups and has long-term stability in vivo. In some aspects, the present disclosure provides methods of treatment using such systems and hydrolysis-resistant crosslinked hydrogels formed from such systems.

The invention relates to the technical field of medical instruments, in particular to a dose adjusting mechanism of an injection device and the injection device. A push rod part penetrates through a holding part and is in threaded connection with the holding part, a sound tooth part sleeves the push rod part and is in circumferential limiting connection with the push rod part, and the push rod part can move in the axial direction relative to the sound tooth part; one-way clamping grooves distributed in the circumferential direction are formed in the circumferential wall defining the containing cavity, the sound tooth part is located in the containing cavity, the sound tooth part is provided with an elastic clamping part, and the elastic clamping part is clamped into any one of the one-way clamping grooves; under the state that the push rod part is pressed, the push rod part can move in the axial direction and drive the sound tooth part to rotate synchronously under the action of the threads, so that the elastic clamping part slides along the peripheral wall defining the containing cavity to be clamped into one of the one-way clamping grooves in the front end. Axial control of the push rod part is converted into rotation control of the sound tooth part, rotation movement of the sound tooth part is discretized into fixed angle grading, the axial displacement of single-time grading of the push rod part is extremely small, and the small-dose injection requirement is met.

The invention belongs to the technical field of injectors, and particularly relates to a forward and reverse rotation adjusting mechanism for an injector and an injection pen. The forward and reverse rotation adjusting mechanism for the injector comprises a rotary drum gear, and ratchets are arranged on the end wall of the rotary drum gear; the dosage knob is rotationally arranged at the end part of the pen body; the push rod rotating cylinder and the rotating cylinder gear are coaxially arranged, and the push rod rotating cylinder is suitable for axially moving relative to the pen body; the drum upper gear is arranged in the dosage knob, sleeves the outer wall of the push rod drum and is meshed with the drum gear; when the dosage knob rotates in the forward direction, the gear on the rotary drum is driven to rotate in the forward direction relative to the rotary drum gear so as to pressurize the coil spring in the pen body. When the dosage knob rotates reversely, the drum upper gear is pushed by the dosage knob to move in the direction away from the drum gear and is disengaged from the ratchet, so that the drum upper gear rotates reversely relative to the drum gear; through cooperation of the drum gear, the drum upper gear and the dosage knob, forward and reverse rotation adjustment of the drum gear is achieved, and the size of the interior of the pen body is reduced.

Provided in the present utility model are a piston control assembly, a piston structure and an anti-suffocation device. The piston control assembly comprises a piston rod, a limiting member and a control structure. The piston rod is internally provided with an accommodating cavity; the limiting member is hinged to the lower middle part of the piston rod, and at least partially protrudes outwards from the outer wall of the piston rod, so as to limit a piston head to the bottom of the piston rod; and the control structure comprises a push rod slidably mounted in the accommodating cavity and a control member slidably fitting with the push rod, wherein when moving downwards, the push rod can push against the limiting member to cause the limiting member to rotate until the outer wall of the limiting member is flush with or recessed into the outer wall of the piston rod, thereby releasing the limiting on the piston head. The push rod is controlled by the control member to move, and the movement of the push rod then causes the limiting member to deflect until the limiting thereof on the piston head is released, such that an independent movement and interlinked cooperation structure is provided for the piston head, and the separated movement or synchronous movement of the piston rod and the piston head can be realized; thus, a negative pressure condition can be formed by means of the independent movement of the piston head, thereby providing a relatively good negative-pressure suction effect.

Biomaterials disclosed herein can comprise a hydrogel comprising PEG, gelatin, and a glycosaminoglycan with sulfated moiety; and chondrogenic, osteogenic, and immunomodulatory cytokines; wherein the biomaterial is capable of potentiating bone regeneration in a compromised wound while reducing inflammatory response. The glycosaminoglycan with sulfated moiety can comprise heparin, heparan sulfate, keratin sulfate, chondroitin sulfate, dermatan sulfate, and / or similar materials. The biomaterial can further comprise mesenchymal stem cells (MSCs), a crosslinking initiator, microparticles and nanoparticles, and or other materials. The biomaterial can be injectable into a wound, or the biomaterial can be loaded in, or further comprise a porous scaffold providing mechanical support for other components of the biomaterial, such that it can be implanted into a wound.

The utility model relates to the technical field of needleless injectors, in particular to a liquid pushing mechanism and an injector, the liquid pushing mechanism comprises a liquid storage assembly, the liquid storage assembly comprises a liquid storage tube and a liquid outlet hole arranged at the end part of the liquid storage tube; the pushing assembly comprises a piston rod arranged in the liquid storage pipe in a sliding mode and a push rod capable of moving relative to the piston rod; the push rod can drive the piston rod to move synchronously when the relative displacement reaches the tail end of the stroke. According to the liquid pushing mechanism and the injector, a relative displacement action exists between the piston rod and the push rod, when the push rod and the piston rod generate relative displacement, the moving speed of the push rod can be increased, when the push rod makes contact with the piston rod, the piston rod can be impacted, and when the piston rod is impacted, the liquid medicine spraying pressure can be increased, so that the epidermis can be punctured conveniently; the piston rod moves along with the push rod in the later period to slowly enter the human body.

The invention provides a disposable injection pen and an injection prompt structure thereof, the injection pen is characterized in that an upper pen shell assembly drives a pre-filled syringe in a lower pen shell assembly to realize an injection function, a rotary sleeve and a screw rod which are rotatably matched are arranged in the upper pen shell assembly, and the injection function of the syringe is completed by axially pushing the screw rod; according to the technical scheme, the sound part which synchronously rotates is arranged on the rotating sleeve, and at the tail end of injection work execution, the sound part axially slides relative to the rotating sleeve and collides with the rotating sleeve in the sliding process to make a prompt tone so as to prompt that injection is completed; the prompt tone of injection completion can be accurately prompted, and the user experience is improved.

The invention belongs to the technical field of radiopharmaceutical injection, and particularly relates to a radiopharmaceutical injection device which comprises a hollow protective barrel, a protective cover is in threaded connection with the top wall of the protective barrel, and the inner circumferential wall of the protective cover and the inner circumferential wall of the protective barrel are in smooth transition. A partition plate is fixedly connected to the inner circumferential wall of the protective barrel, a movable plate is longitudinally connected to the inner circumferential wall of the protective barrel in a sliding mode, the partition plate divides the space of the inner wall of the protective barrel into an air pressure cavity and an injection cavity, and an injection hole is formed in the bottom wall of the protective barrel and communicates with the injection cavity; before radioactive medicine is injected, blood vessels are guaranteed to be unobstructed, after injection is completed, residual medicine is removed and injected into the body of a patient, vasospasm can be monitored in real time when the radioactive medicine is injected, and when spasm is caused by the medicine, injection of the radioactive medicine is stopped, and medical staff can conveniently intervene in time.

A filling aid. The filling aid includes a locking portion including a groove feature; and a locking feature having a locked and an unlocked position; and a filling syringe holder slidably attached to the locking portion, the filling syringe holder including a filling needle cradle portion having a tongue feature; and a needle housing portion comprising at least one tab having a starting position and a filling position, wherein the groove feature configured to accommodate the tongue feature, and wherein the locking feature interact with the filling syringe holder wherein when the locking feature moves from the locked position to the unlocked position the needle housing portion moves from the starting position to the filling position.

The present invention relates to an injection device comprising: an injection mechanism comprising an injection rod; the adjusting mechanism comprises a dose indicating dial, a first elastic piece and an adjusting bracket; one of the adjusting support and the auxiliary part is provided with a pawl, the other one of the adjusting support and the auxiliary part is provided with a ratchet part, and the pawl is matched with the ratchet part; when the set dosage is adjusted, the auxiliary part does not rotate; a housing; when the set dose needs to be increased, the adjusting support rotates in the first direction, the dose indicating dial can be driven to rotate, and the first elastic piece can be driven to twist; when the set dose needs to be reduced, the pawl and the ratchet part are disengaged and are in contact, the adjusting support rotates in the second direction, the dose indicating dial can be driven to rotate reversely, and torsion of the first elastic piece is reduced; and when injection is carried out, the first elastic piece rebounds, so that the injection rod spirally moves. According to the injection device, the set dosage can be increased or decreased, the dosage can be accurately and finely adjusted, and a user can easily and accurately adjust the dosage.

A method of coating a polymer surface is provided, comprising providing a polymer having a surface, optionally treating at least a portion of the polymer surface with an oxidizing agent, treating at least a portion of the polymer surface with a composition comprising a polysaccharide, an oligosaccharide, a polyol, or a mixture thereof, and incubating the treated polymer with the composition for a period of time. Also disclosed are polymers comprising such coatings, containers comprising such coated polymers, and medical devices comprising such polymers.

The utility model discloses a hydrotherapy needle. The hydrotherapy needle comprises a needle body, a needle seat and a needle cap, a first positioning structure is arranged on the needle seat and is used for identifying the position of the needle seat by a machine; the needle cap is connected with the needle base in a matched mode, a second positioning structure is arranged on the needle cap and used for recognizing the position of the needle cap relative to the first positioning structure and the orientation of the needle cap through a machine, and the needle body is suitable for being fixed through the needle base and / or the needle cap. When an automatic machine is used for positioning and assembling the needle base and the needle cap, the first positioning structure and the second positioning structure can serve as recognition feature points of the needle base and the needle cap respectively, and then the positioning precision and the assembling precision of the machine for the needle base and the needle cap are improved. According to the technical scheme, the problems that an existing hydro-optical needle is low in assembling precision and assembling efficiency are solved, and assembling convenience of the hydro-optical needle is improved.

The invention relates to the technical field of medical instruments, in particular to a dose adjusting mechanism of an injection device and the injection device. The push rod part penetrates through the holding part and is in threaded connection; the push rod part is sleeved with the transmission tooth part and limited in the circumferential direction, and the push rod part can move in the axial direction relative to the transmission tooth part. The transmission tooth part comprises a driven ratchet; the driving rod part can be switched from an initial position to an end position, and at the initial position, the driving ratchet and the driven ratchet are spaced in the axial direction and staggered by a preset angle in the circumferential direction; at the ending position, the driving ratchet is meshed with the driven ratchet, and the transmission tooth part rotates by an angle of one driving ratchet; the reset part drives the driving rod part to return to the initial position when the pressing force is released. The rotation angle of the transmission tooth part corresponds to the axial displacement of the push rod part, rotation of the transmission tooth part is discretized through one-by-one meshing of the driving ratchets and the driven ratchets, the single displacement of the push rod part is smaller, and the small-dose injection requirement is met.

The invention discloses an automatic injection pen which comprises a pen container shell with the open front end, a pre-filling syringe is arranged in the pen container shell, a medicine pushing rod and a locking mechanism are arranged in the pen container shell, and an unlocking structure is further connected to the pen container shell in a sliding mode. The pen container shell is further provided with a first elastic element which pushes the medicine pushing rod to collide with a piston of the pre-filled syringe after the locking mechanism is unlocked so as to make a first prompt sound and enable the pre-filled syringe to conduct injection. And a prompting piece is arranged between the medicine pushing rod and the pen container shell, wherein the prompting piece is locked when the medicine pushing rod is in the initial state, and the prompting piece is unlocked when the injection of the pre-filled syringe is finished after the medicine pushing rod advances by a second preset distance, so that the prompting piece collides with the pen container shell to give out a second prompting sound. The product can respectively generate clear and distinguishable sounds at two key nodes of injection starting and injection completion, so that a user can accurately judge the injection process without depending on vision, the product is suitable for visual impairment people or operation in an emergency scene, and the medication safety and psychological safety are improved.

According to the disposable injection pen and the injection unlocking structure thereof, a pre-filled syringe is assembled in a lower pen shell assembly and is driven by a driving device in an upper pen shell assembly to conduct injection, in the injection process, the lower pen shell assembly drives a rotary sliding block in the upper pen shell assembly to move upwards so that an injection needle can be exposed, the rotary sliding block slides on a fixed sleeve, and therefore the injection needle can be unlocked. The driving device in the upper pen shell assembly is unlocked in the sliding process, the rotary sliding block which is rotatably arranged axially slides before reaching the unlocking position, and the rotary sliding block rotates after reaching the unlocking position and collides with the fixed sleeve to make an unlocking prompt tone, so that a user can accurately know the injection starting condition; and the subsequent injection action can be accurately carried out.

An injection system includes an injection system body, a proximal stopper member, and a distal stopper member, wherein the proximal stopper member, the distal stopper member, and the injection system body form proximal and distal drug chambers. The system further includes a plunger member configured to insert the proximal stopper member relative to the injection system body. Moreover, the system includes a needle hub assembly coupled to the syringe body at the syringe body distal end, and including a needle hub and a needle. The distal stopper member includes a ball having a lodged state and a dislodged state. When the ball is in the lodged state, the ball forms an openable barrier between the proximal and distal drug chambers. The distal stopper member is configured to selectively allow flow from the proximal drug chamber to the distal drug chamber.

The invention discloses an injection dosage adjusting mechanism and an injection pen, and relates to the technical field of medical instruments, the injection dosage adjusting mechanism comprises an adjusting outer cylinder and a driving inner cylinder which are coaxially arranged, the adjusting outer cylinder is used for being in threaded fit with a pen shell assembly, and the pen shell assembly is used for providing a mounting space for the injection dosage adjusting mechanism; a plurality of ratchet grooves are formed in the inner wall of one end of the adjusting outer cylinder, and the ratchet grooves are continuously arranged around the central axis of the adjusting outer cylinder; the driving inner cylinder is arranged in the adjusting outer cylinder, a bidirectional ratchet is arranged at one end of the driving inner cylinder, ratchet elastic pieces capable of being embedded into the ratchet grooves are arranged at the two ends of the bidirectional ratchet, and when the adjusting outer cylinder rotates forwards or reversely relative to the driving inner cylinder, the ratchet elastic pieces can collide with the ratchet grooves to produce sound. Therefore, when the dosage of the liquid medicine is increased and decreased, sound prompt can be realized at the same time. The injection dosage adjusting mechanism disclosed by the invention has the advantages of few parts, simple assembly process and low production cost.

The present application relates to a medicament delivery device comprising a housing, a medicament container holder arranged to accommodate a medicament container, a needle assembly comprising an injection needle part and a penetration needle part, wherein the extension of the injection needle part and the extension of the penetration needle part are angled generally 90 degrees, a penetration mechanism arranged to move the needle assembly in a direction generally coinciding with the extension of the injection needle part between an initial position of the injection needle part inside said housing to a penetration position with the injection needle part extending outside said housing; a medicament container connection mechanism arranged to move the medicament container holder and the medicament container in a direction generally coinciding with the penetration needle part for creating a flow passage from the interior of the medicament container to an outlet of the injection needle part.

The invention discloses a multi-dose injection pen, and relates to the technical field of medical instruments, the multi-dose injection pen comprises a pen body, a dose adjusting assembly and a driving assembly, the dose adjusting assembly and the driving assembly are installed in an inner cavity of the pen body, a dose indicator is rotated when injection dose is adjusted, dose readings on the outer surface of the dose indicator directly face a reading window, and a sleeve rotates synchronously. Further, the torsion of the torsion spring is increased, and pre-stress is accumulated for injection; during injection, the driving assembly is pressed in the axial direction, the torsion of the torsion spring is released, and the torsion spring recovers to the initial torsion state after a set medicine dosage is injected; the torsion spring comprises the first spiral section and the second spiral section, one end of each spiral section is connected to the shell cover, the other end of each spiral section is connected to the sleeve, compared with a traditional structure, larger torsion can be generated when the torsion spring rotates by the same angle, and the number of rotation turns needed by the torsion spring with the same prestressing force is reduced.

The present application relates to a dose accumulation mechanism comprising: a drive worm provided with a drive rib; the matching component is connected with the driving worm in a sleeving manner; the integral worm gear is connected to the matching component and provided with a plurality of meshing grooves, and the meshing grooves are used for meshing of the driving ribs; the first limiting part is arranged on the driving worm or the matching part; the second limiting part is arranged on the integral worm gear; during dose setting, the driving worm can rotate relative to the matching part in the first direction to increase the dose and rotate in the second direction to decrease the dose; during dose injection, the drive worm is in anti-rotation connection with the mating member; when the first limiting part abuts against the second limiting part, a stop position of the integral worm gear is formed, and when the integral worm gear is located at the stop position, the driving worm is prevented from continuously moving in the first direction relative to the matching component. According to the invention, the movement of the integral worm gear can be limited, so that the maximum dose which can be set can be limited.