130 results about "Intestinal walls" patented technology

The invention relates to the technical field of image focus detection, in particular to a fiber endoscope image focus detection method and system, and the method comprises the following steps: providing a data quality guide interface; capturing narrow-band light images of the endoscope away from a first preset position and a second preset position of the intestinal wall in the axial movement process, calculating brightness gain values of a blue light channel and a green light channel, calculating an asymmetric scattering correction coefficient, and updating indication of color information calibration integrity; tracking the pixel moving speed of the interferent in the view in the propulsion operation process, calculating the relative depth of the interferent, and updating the indication of the validity of the depth data of the interference layer; identifying the image area which is not shielded by the interferent, and updating the indication of the information coverage degree of the background area; triggering an image synthesis operation; performing color compensation on the image information of the image area which is stored in the background canvas and is not shielded by the interferent; reconstructing a clear image; and performing focus detection on the clear image. The method improves the accuracy of focus detection.

The invention relates to the technical field of image enhancement, and discloses an intestinal dynamic MRI image enhancement method and system based on deep learning, through the image enhancement method based on deep learning, the quality of a small intestine cine-MRI image is improved, the problems of low resolution and poor contrast of a traditional image are improved, and the identifiability of a small intestine intestinal wall structure is enhanced. On the basis, pixel-level registration processing of continuous frame images is combined, the intestinal segment movement track is accurately extracted, and movement parameters such as contraction frequency, lumen diameter variation amplitude, pixel displacement mean value and variance are calculated. Furthermore, a pre-training evaluation model is utilized to intelligently output a small intestine dynamic state judgment result based on motion parameters, and standardized auxiliary recognition of small intestine dynamic disorder diseases and severity of the small intestine dynamic disorder diseases is achieved. According to the method, the image processing quality, the motion feature extraction accuracy and the evaluation intelligence level of small intestine dynamic evaluation are integrally improved, and the method has important clinical application value and popularization significance.

The invention discloses a self-breaking outer drainage tube, and relates to the technical field of medical instruments, the self-breaking outer drainage tube comprises a tube body, and the tube body comprises a drainage part, a breaking part, a leading-out part and a puncture part; the drainage part and the fracture part are both made of degradable materials; the hole wall thickness of the circulation hole at the fracture part is smaller than the hole wall thickness of the circulation hole at the drainage part; during surgical operation, the degradable inner drainage part is placed in the pancreatic duct, the fracture part crosses the anastomotic stoma by 7-8 cm and crosses the biliary-intestinal anastomotic stoma, and the leading-out part walks in the enteric cavity to a proper position, penetrates out of the intestinal wall and is led out of the body through the abdominal wall. Cutting the puncture part to expose the outlet of the circulation hole, and discharging the body fluid through the circulation hole; after a certain period of time after the operation, the fracture part is automatically fractured under the action of pancreatic juice, the leading-out part is pulled out, the degradable drainage part continues to be degraded in the body and maintains the drainage function, and finally the drainage part is absorbed by the body or discharged out of the body without being taken out through the operation.

The invention relates to the field of medical apparatus and instruments in rectum surgery, and particularly provides a novel multifunctional intestinal bypass device for rectum surgery, which comprises a hollow sleeve, a film sleeve, a decompression air bag sleeved outside the hollow sleeve, and an inflation channel, wherein after being inflated, the decompression air bag protrudes in a corrugated or threaded mode in the axial direction of the hollow sleeve, the protruding part makes contact with the intestinal wall to provide friction force, and a decompression gap is formed between the sunken part and the intestinal wall; according to the invention, intestinal contents are discharged from the hollow sleeve and the film sleeve, so that excrement or intestinal juice is prevented from being in contact with an anastomotic stoma, the infection risk of the anastomotic stoma is reduced, and the healing rate of the anastomotic stoma is accelerated; the thin film sleeve is soft and deformable, so that discomfort such as anus falling expansion, pain and tenesmus of a patient can be effectively reduced, and the comfort of the patient is improved; the decompression air bag is expanded through the inflation channel, the hollow sleeve is positioned, meanwhile, blood supply of the intestinal wall is protected, and the reliable effect of replacing preventive fistulization is achieved.

The invention relates to the technical field of tumor risk assessment, in particular to an intestinal tumor risk assessment method based on image analysis, and the method comprises the steps: carrying out the continuous image division and parameter collection; identifying abnormal density image blocks; identifying concerned risk image blocks; judging a response risk image block; adjusting a preset synchronization degree risk threshold value; early warning judgment is carried out, and a serious early warning report is generated. According to the method, a self-adaptive and dynamically-adjusted three-level judgment system is established through real-time collaborative analysis of multi-dimensional parameters of an enteroscope image block, firstly, a suspected focus is locked based on the texture change duration, then, the focus characteristics are verified through vascular abnormality and contrast fluctuation depth, and finally, the accuracy of the focus is improved. And finally, the risk threshold is corrected in combination with intestinal wall peristalsis and the lens shielding degree, so that the problem of low early flat tumor recognition accuracy caused by insufficient flat tumor image feature capture due to excessive dependence on intestinal environment microorganism and metabolite biochemical detection is effectively solved.

The invention discloses a drug delivery device in a human body cavity, which comprises an inflatable balloon, at least one part of the outer wall of the balloon is provided with a protective shell, the balloon is provided with an inner cavity, and the protective shell can be dissolved by specific body fluid in the human body cavity; the triggering part is arranged in an inner cavity of the balloon, and the triggering part can react with body fluid to generate fluid to inflate the balloon when making contact with the body fluid, so that the inflated balloon is tightly attached to the wall of a body cavity; the propelling part is arranged in the inner cavity of the balloon and comprises a tissue penetrating component, and the triggering part can generate power to propel the tissue penetrating component; and the containing part is used for containing a medicine preparation, and the triggering part can push and press the liquid medicine preparation contained in the containing part into the pushing part after the balloon is inflated, and injects the liquid medicine preparation into the inner wall tissue of the human body cavity through the tissue penetrating component. By means of the device, macromolecular drugs or preparations can be injected into the inner wall of the human body cavity, such as the tissue of the intestinal wall.

The invention relates to biomedical engineering, and discloses a biochip screening method of a therapeutic agent based on intestinal brain axis regulation and application thereof. The screening method comprises the following steps: performing intestinal wall cell culture or microglial cell culture by adopting a metasurface plasmon resonance biochip of which the surface is subjected to bionic treatment to obtain an intestinal wall cell adherent chip board or a microglial cell adherent chip board; the method comprises the following steps: adding a culture medium containing a chemotherapeutic drug or lipopolysaccharide into a cell-adherent chip board for culture I, then removing the culture medium, adding a therapeutic agent to be detected for culture II to obtain a culture solution, and detecting the cell repair effect of intestinal wall cells or microglial cells in the culture solution, and screening to obtain a therapeutic agent with a repairing effect on intestinal wall cells and / or microglial cells. The screening method can be used for efficiently and accurately screening the therapeutic agent with dual effects of intestinal regulation and neuroprotection from a plurality of therapeutic agents to be detected, and can be used for dynamically monitoring and exploring the interaction condition of the therapeutic agent and cells on line in an unmarked and real-time manner.

The mouse intestinal tumor cell injector comprises a handle, an injection device installed in the handle, and a radially telescopic support ring structure connected with the handle, tumor cells can be discharged from a first injection needle by operating a first push rod, and antibiotics can be discharged from a second injection needle by operating a second push rod; when the support ring structure is in a contracted state, the first injection needle and the second injection needle are located in the support ring structure; when the support ring structure is in an expanded support state, the needle heads of the first injection needle and the second injection needle can both extend to the outside of the outer edge of the support ring structure and are inserted into the mouse intestinal wall. The present application supports the mouse intestine by the support ring structure, supports the insertion of the first injection needle and the second injection needle into the mouse intestinal wall, ensures that only the mouse intestinal endothelium is punctured and the mouse intestinal canal is not punctured, ensures that tumor cells are injected into the mouse intestinal wall, and when the tumor cells are injected, antibiotics are also injected for anti-inflammatory treatment, which is beneficial to the recovery of the mouse intestinal puncture point.

This invention discloses a capsule system for electro-adhesion in the digestive tract and its operating method, relating to the field of medical devices. The system includes a transparent outer shell forming a sealed cavity within it; multiple electrode adhesion units are axially arranged on the outer wall of the shell; an image acquisition device is fixed inside the shell, with its acquisition end adjacent to the transparent end of the shell; a wireless transmission device is used for bidirectional wireless data transmission with an external workstation; when the drug storage device's release port is open, the drug within the storage device can be released to the outside; a control module can control the opening and closing of the release port, and can control the power supply to the electrode adhesion units, as well as the direction of current flow after power is applied; a power supply is electrically connected to the image acquisition device, the wireless transmission device, the drug storage device, and the control module. The system and its operating method of this invention can save internal capsule space, avoid mechanical damage to intestinal wall tissue, and the anchoring and release process is rapid, controllable, and reversible.

The invention discloses an endoscopic positioning mark clamp, which comprises a clamp main body in a tubular shape, two axial ends of the clamp main body are respectively provided with a pipe orifice; the chuck is arranged at the front end of the clamp main body and is provided with a first arm and a second arm which are exposed out of the front end of the clamp main body and can be opened and closed; the head end of the inhaul cable is connected with the chuck in a detachable mode, the tail end of the inhaul cable extends backwards to the outside of the clamp body in the axial direction, and opening and closing of the first arm and the second arm can be operated; the magnetic block is arranged in the clamp main body; the rope loop is arranged at the rear end of the clamp main body; the clamp body, the clamping head, the inhaul cable and the rope loop are all made of non-magnetic materials. According to the positioning marking clamp under the endoscope, the clamp can be clamped to the intestinal wall tissue through the endoscope clamp channel, the distance between the magnetic block and the intestinal wall tissue is short, and an iron surgical instrument outside the intestinal wall tissue can more conveniently detect the position of the magnetic block.

A double-needle bidirectional barb surgical suture with a buckle ring in the middle comprises a single suture, suture needles are arranged at two ends of the suture, barb suture bodies on two sides of the suture are respectively provided with barbs with barbs pointing to the middle, the buckle ring is arranged in the middle of the barb suture bodies, and the barb suture bodies are made of absorbable materials. After the sutured first needle is used for suturing the tissue, the suture needle on one side penetrates into the buckling ring and then is tensioned, so that the first needle is used for suturing the tissue and is locked, and tissue damage caused by excessive traction of the barb line on the other side of the buckling ring towards the barb opening direction in the traction process when the suture needles on the two sides are continuously used for suturing the tissue subsequently can be avoided; by means of the device, the suture line can be conveniently pulled to twist the intestinal canal in the surgical anastomosis operation process of the gastrointestinal tract, so that an operation operator can conveniently suture the lateral and dorsal intestinal walls, and the gastrointestinal tract operation, especially the gastrointestinal tract anastomosis under a laparoscope, can be facilitated.

The invention relates to the technical field of medical instruments, in particular to an enteric cavity segment filling controllable device for colon cancer preoperative T staging, which comprises a central mandrel, a flexible head end cap is arranged at the foremost end of the central mandrel, and a near-end balloon inflating pipeline, a far-end balloon inflating pipeline and a main pipeline which are mutually independent are arranged in the central mandrel; the near-end balloon is arranged on the central mandrel in a sleeving manner and is communicated with the near-end balloon inflating pipeline; the far-end balloon is arranged on the central mandrel in a sleeving manner, is positioned on the far side of the near-end balloon and is communicated with the far-end balloon inflating pipeline; at least two main pipeline lateral holes are formed in the tube wall of the central mandrel between the near-end balloon and the far-end balloon, are communicated with the main pipeline and are used for injecting a contrast agent or normal saline into the closed enteric cavity section between the two balloons. The near-end balloon and the far-end balloon are synchronously filled at the two ends of a target intestinal segment to form a closed segment, and a contrast agent is uniformly injected through lateral opening, so that the intestinal wall is fully expanded and does not collapse, and the display definition of the five-layer structure of the intestinal wall is remarkably improved.

The invention belongs to the technical field of medical instruments, and discloses a gastrointestinal tract magnetic clipping fistulization assembly and application thereof. The assembly comprises at least two magnetic bodies, each magnetic body is provided with a clamping end face, the effective length of each clamping end face is 3-5 cm, the width of each clamping end face is not smaller than 0.2 cm, and a clamping gap of 2-4 mm is formed between the stomach wall and the intestinal wall when the two magnetic bodies are attracted. The assembly can adopt an integral structure, a split structure, a bendable structure or a concave-convex clamping structure, and the magnetic body is provided with a fixing structure and a guide assembly. Laparotomy and minimally invasive implantation are not needed, permanent foreign matter residues are avoided, a stable permanent anastomosis channel can be formed, the risk of complications such as adhesion and leakage is reduced, the device is suitable for patients with refractory digestive tract obstruction, and fistulization safety and success rate are improved.

The invention relates to a magnetic control self-conformal intestinal stent and a dynamic monitoring system, and belongs to the technical field of medical instruments, and the magnetic control self-conformal intestinal stent comprises a biodegradable main skeleton, a magnetic driving unit, a pressure sensing array and an in-vitro control device. A magnetic response material is embedded into the main framework, and form regulation and control and degradation rate control are realized through an in-vitro magnetic field; the flexible sensing array monitors intestinal wall pressure in real time, and the self-adaptive structure is linked to dynamically adapt to the intestinal tract curved surface. The in-vitro device integrates magnetic field adjustment and data processing, and supports precise positioning of the support and intelligent adjustment of the attaching force. The system improves the stability in a complex intestinal environment through magnetic coupling driving and multi-mode monitoring, early warns abnormal risks in real time, and avoids the rigid defect and monitoring lag problems of a traditional stent. The biodegradable material is combined with intelligent control, the degradation process and tissue repair are synchronized, a safe and effective treatment scheme is provided for diseases such as intestinal obstruction, and the treatment effect of a patient is improved.

The present disclosure relates to the field of drug delivery, in particular, the present disclosure relates to a microneedle drug delivery device and a preparation method thereof. The device comprises a substrate, a microneedle array and a liquid-absorbing swelling material, the substrate carries the microneedle array, and the liquid-absorbing swelling material is arranged between the substrates to form a sandwich structure. The device uses a mild water-absorbing swelling mechanism and the natural peristalsis of the gastrointestinal tract to pierce the microneedles into the intestinal wall, complete drug delivery, physically break through the physiological barrier of oral delivery and absorption of biological drugs, and improve the oral bioavailability of biological drugs. The materials used are all biodegradable soft materials, which are safe.

The invention relates to the technical field of artificial intelligence, and provides an eosinophilic gastroenteritis typing system and method based on multi-modal data, and the method comprises the steps: obtaining a digestive endoscopy image, an ultrasonic endoscopy image, a CT examination image and clinical manifestation data of a to-be-detected person collected in the same time period; the gastrointestinal mucosa lesion state is recognized through a digestive endoscopy image and is represented by numerical features; identifying the abnormal thickening condition of each film layer structure of the gastrointestinal wall through an ultrasonic endoscope image, and representing the abnormal thickening condition by numerical features; lesion hierarchical distribution is judged through an ultrasonic endoscope image, and numerical feature representation is carried out; determining seroperitoneum and intestinal wall thickening conditions through a CT examination image, and performing numerical characteristic representation on the seroperitoneum and intestinal wall thickening conditions; clinical symptom features are obtained through the clinical manifestation data and are represented by numerical features; generating a feature vector based on multi-modal data by using each numerical value feature representation; and inputting the feature vectors into a dynamic typing prediction model to realize the typing prediction of eosinophilic gastroenteritis, thereby improving the accuracy of auxiliary diagnosis and evaluation.

The invention relates to an operation device, in particular to a portable anorectal operation auxiliary device which comprises a handheld gun handle, a gun barrel and an exploring tube, the hollow gun barrel is connected to the front end of the handheld gun handle, a guide hole is horizontally formed in the upper portion of the handheld gun handle, the front end of the guide hole is communicated with an opening in the rear end of the gun barrel, and the exploring tube can slide into the gun barrel through the guide hole. The front end of the exploring tube is connected with a probe. In the aspect of cleaning the camera, the water pipe and the annular nozzle are arranged at the position of the probe, when the device is externally connected with a water source, water flows through the water pipe and is evenly sprayed out of the annular nozzle, the camera can be cleaned in time, intestinal wall mucus or dirt interference of a patient is avoided, clear imaging is guaranteed, operation cleaning does not need to be interrupted, and medical operation efficiency is greatly improved. Meanwhile, the device is provided with a distraction mechanism, the closed probe can be protected, friction damage between the closed probe and the intestinal wall is reduced, the internal space can be slightly distraction and expanded according to the anorectal condition of a patient, the passing rate of the probe is increased, convenient conditions are created for subsequent medical operation, and the device has practicability and innovativeness.

The invention relates to a system for intestinal delivery of therapeutic agents. Described herein are systems for enteric delivery of therapeutic agents, and methods of administering therapeutic agents to a patient by oral administration of an enteric delivery system. An intestinal delivery system includes one or more carrier members comprising a carrier polymer and a therapeutic agent, and the system may be configured in a compressed configuration and an expanded configuration, and sized to maintain contact with an intestinal wall of a small intestine by applying an outward pressure to the intestinal wall, and transporting at least a portion of the therapeutic agent across the intestinal mucosa of the small intestine.

The present invention discloses an intestinal flow field modeling method and device based on bidirectional fluid-solid coupling. The method comprises: S1, collecting intestinal multimodal data; wherein the multimodal data includes geometric parameters, motion characteristics, content statistics and wall stress and strain data of the intestine; S2, reconstructing a three-dimensional geometric model of the human intestine; S3, preprocessing the established intestinal geometric model by format conversion and simplification and modification; S4, dividing the preprocessed model into a fluid domain and a solid domain, and establishing a bidirectional fluid-solid coupling model architecture; S5, performing fluid domain simulation settings: simulating multiphase flow contents and setting a fluid simulation model; S6, performing solid domain simulation settings: setting intestinal wall material parameters and simulating intestinal movement; S7, achieving bidirectional fluid-solid coupling and simulating the intestinal flow field. The method takes into account the bidirectional interaction between the intestinal wall solid domain and the intestinal content fluid domain, achieving more accurate intestinal flow field simulation.

The application belongs to the technical field of medical devices, and particularly relates to a kind of cryoablation catheter and ablation system, the cryoablation catheter includes inner catheter and outer catheter, the outer catheter is coaxially sleeved on the outside of inner catheter, the inner catheter is configured as a multi-lumen structure, further comprising: a plurality of sealing components, a plurality of the sealing components are arranged on the outside of inner catheter;Wherein, in the initial state, a plurality of the sealing components and inner catheter are located in the inside of outer catheter, in the working state, a plurality of the sealing components and intestinal wall form an ablation closed space together. The application guides the cryoablation catheter to the target position through the guide wire, forms the ablation closed space through the cooperation of sealing components and lumen wall, inputs the cryogenic medium into the ablation closed space to freeze and ablate the lumen wall, provides a usable treatment plan for type 2 diabetes, obesity or other lumen lesion patients, and has the advantages of small trauma, less pain for patients, low surgical risk, etc.

The invention discloses a drug delivery device in a human body cavity, which comprises an inflatable balloon, at least one part of the outer wall of the balloon is provided with a protective shell, the balloon is provided with an inner cavity, and the protective shell can be dissolved by specific body fluid in the human body cavity; the triggering part is arranged in an inner cavity of the balloon, and the triggering part can react with body fluid to generate fluid to inflate the balloon when making contact with the body fluid, so that the inflated balloon is tightly attached to the wall of a body cavity; the propelling part is arranged in the inner cavity of the balloon and comprises a tissue penetrating component, and the triggering part can generate power to propel the tissue penetrating component; and the containing part is used for containing a medicine preparation, and the triggering part can push and press the liquid medicine preparation contained in the containing part into the pushing part after the balloon is inflated, and injects the liquid medicine preparation into the inner wall tissue of the human body cavity through the tissue penetrating component. By means of the device, macromolecular drugs or preparations can be injected into the inner wall of the human body cavity, such as the tissue of the intestinal wall.

The invention relates to the technical field of rectum foreign matter grabber, and particularly discloses a rectum foreign matter grabber which comprises a catheter, the catheter is of a circular ring structure, the surface of the catheter is coated with lubricating oil in the using state, and the inner wall of the catheter is provided with an adsorption assembly used for storing foreign matter. The adsorption assembly and the deformation assembly are used in cooperation, the structure of the device can be changed in the using process of the device, then the foreign matter can be adsorbed through the internal structure, and the foreign matter can be cut and clamped through the deformation assembly. Therefore, foreign matter does not make contact with the inner wall of the intestinal tract in the moving process, the intestinal tract is prevented from being scratched, equipment is safer to use, meanwhile, the direction of a needle can be adjusted in the needle taking process to be consistent with the overall direction of the equipment, the situation that the inclination angle between the needle and the overall equipment is too large, and consequently the intestinal tract is scratched is avoided, and the service life of the equipment is prolonged. And furthermore, the equipment is safer to use.

This invention relates to the field of intelligent medical technology, and more particularly to a method for early warning of intestinal fibrosis in Crohn's disease based on a large model. The method includes: acquiring intestinal MRI image sequences of Crohn's disease patients; inputting the intestinal MRI image sequences into a pre-trained large model for intestinal structure analysis to locate the initial intestinal fibrosis region; determining whether the degree of intestinal luminal stenosis in Crohn's disease patients meets the standard based on the intestinal stenosis progression index, and adjusting the feature contrast threshold of the large model based on the difference; determining whether the acute inflammation masking effect of Crohn's disease patients is adequate based on intestinal wall edema characterization parameters, and adjusting the T2-weighted imaging modal weights of the large model based on the relative difference; and determining whether the patency of the fibrotic permeation channel in Crohn's disease patients is adequate based on the fibrotic permeation resistivity, and adjusting the boundary loss weights of the large model based on the ratio. This invention improves the accuracy of early warning of intestinal fibrosis in Crohn's disease.

The invention relates to the field of medical apparatus and instruments, and discloses a rectum low tumor insection edge measuring and positioning device in laparoscopic surgery, the rectum low tumor insection edge measuring and positioning device comprises an inflating and positioning device, an inflating channel and a miniature inflating pump, the inflating and positioning device is composed of a silica gel air bag and a retractable supporting framework assembly, the supporting framework assembly is arranged in the silica gel air bag, and the inflating channel is communicated with the inflating and positioning device; the bottom end of the silica gel air bag is fixedly connected with an integrated inflation channel, the bottom end of the inflation channel is fixedly connected with a miniature inflation pump, the inflation positioning device can be fed into the body through the anus, the miniature inflation pump inflates the inflation positioning device through the inflation channel, the inflation positioning device is in an expanded and full state, the peripheral side wall is attached to the intestinal wall, and the supporting framework assembly is matched. The three-dimensional shape in a full-gas state is guaranteed, and a series of problems that in an existing laparoscopic surgery, the accuracy is poor, anastomosis is not easy, or excision is not thorough due to the fact that the specific position is judged through hand touch or an endoscopic surgery instrument serves as a reference object for locating the lower incisal edge of the rectum low tumor in the laparoscopic surgery at present are solved.

The invention discloses a flow guide fixing device for enteric cavity wall isolation, and relates to the field of medical instruments. The tubular flow guide support is fixed through the strapping tape with the adjustable clamping degree, standardization of the strapping and fixing technique is achieved, and the strapping and fixing process of the intestinal canal and the cavity wall isolation flow guide process are more efficient, more convenient, safer and firmer. The ribbon body with a certain width is adopted to fix the tubular diversion stent, so that blood vessels are not prone to being excessively pressed or damaged, and the optimal physiological healing condition of intestinal canals can be completely met. The strapping tape and the tubular flow guide support are both made of medical degradable materials and can be absorbed or degraded by the human body after the intestinal canal anastomotic stoma is healed, and the tubular soft film sleeve can be discharged out of the human body along with degradation of the tubular flow guide support, so that the device does not have any residue in the human body, and the device does not need to be taken out again. According to the invention, enteric cavity wall expansion and cavity wall isolation diversion which meet the physiological healing condition of the intestinal canal can be safely and reliably carried out on the intestinal canal, and the fixation of the intestinal canal on the enteric cavity wall can be completed through convenient and standard operation.

The invention belongs to the technical field of medical instruments, and provides a transanal colorectal ectropion traction device which comprises a flexible body, a control handle and a sterile air source unit. The flexible main body sequentially comprises a core rod, an inner-layer supporting air bag, a nickel-titanium alloy self-adaptive deformation framework and an outer-layer attaching air bag from inside to outside; the core rod is installed on the control handle, and the inner-layer supporting air bag and the outer-layer attaching air bag are both installed on the core rod. The nickel-titanium alloy self-adaptive deformation framework is embedded between the inner-layer supporting air bag and the outer-layer attaching air bag in a sealed mode, a floating embedded structure is adopted, and the nickel-titanium alloy self-adaptive deformation framework and the air bag wall are not directly bonded and fixed. An independent inflation cavity is formed in the outer layer attaching air bag, and a plurality of micro-negative-pressure adsorption heads are arranged on the outer wall of the outer layer attaching air bag. A bearded needle puncture structure is completely abandoned, non-invasive fixation is achieved through the micro negative pressure adsorption head, the risks of intestinal wall puncture injury, bleeding and perforation are avoided, tumor cells are prevented from falling off and being planted, and the application range of the device in malignant colorectal tumor surgery is widened.

The application provides a microneedle capsule for delivering injection drugs and an application thereof, and relates to the technical field of medicines, and comprises a capsule, a power device arranged in the capsule, and a plurality of injection microneedles between the capsule and the power device; the power device comprises an elastic component and a limiting mechanism, the elastic component is arranged correspondingly to the plurality of injection microneedles; one end of the limiting mechanism is connected with the capsule, and the other end is connected with the elastic component; the limiting mechanism is used for limiting the elastic component to be in a contraction state, and the limiting mechanism is composed of a material which is degraded in an intestinal tract. The capsule is wrapped to be capable of being delivered to the intestinal tract, the limiting mechanism is degraded in the intestinal tract, the elastic component pushes the injection microneedles to move along the extension direction of the elastic component, the injection microneedles are punched out of the capsule, the injection microneedles are released, and the released injection microneedles penetrate the intestinal wall tissue subsequently, and the injection drugs carried by the injection microneedles are injected into the intestinal wall tissue. The technical problem that injection drugs are difficult to be administered by an oral mode in the prior art is solved.

The utility model discloses a water injection pump instant heater for an endoscope room, which comprises a shell, a pipe placing hole is arranged at the circle center of the upper surface of the shell, a heating sheet for heating a drainage pipe is arranged on the inner wall of the pipe placing hole, the shell comprises a left shell and a right shell, the left shell and the right shell are horizontally and symmetrically arranged, an existing water injection pump bucket is provided with a bucket cover, the bucket cover is externally connected with the drainage pipe, and the drainage pipe is connected with the water injection pump. And the drainage tube is clamped and fixed between the side wall of the left shell tube placing hole and the side wall of the right shell tube placing hole. The connecting surfaces of the left shell and the right shell are respectively provided with a plug and a socket, and the plug is inserted into the socket, so that the left shell is electrically connected with the right shell. The heater can be rapidly installed on the drainage tube of the water injection pump and heat the drainage tube, normal saline is prevented from being cold, the comfort degree of a patient when the normal saline is injected into the intestinal tract can be improved, the situation that the intestinal tract wall is stimulated by cold water is reduced, the peristalsis of the intestinal tract and the spasm of the intestinal tract are reduced, and the operation difficulty of an enteroscope is lowered.

The invention discloses a drug delivery device in a human body cavity, which comprises an inflatable balloon, at least one part of the outer wall of the balloon is provided with a protective shell, the balloon is provided with an inner cavity, and the protective shell can be dissolved by specific body fluid in the human body cavity; the triggering part is arranged in an inner cavity of the balloon, and the triggering part can react with body fluid to generate fluid to inflate the balloon when making contact with the body fluid, so that the inflated balloon is tightly attached to the wall of a body cavity; the propelling part is arranged in the inner cavity of the balloon and comprises a tissue penetrating component, and the triggering part can generate power to propel the tissue penetrating component; and the containing part is used for containing a medicine preparation, and the triggering part can push and press the liquid medicine preparation contained in the containing part into the pushing part after the balloon is inflated, and injects the liquid medicine preparation into the inner wall tissue of the human body cavity through the tissue penetrating component. By means of the device, macromolecular drugs or preparations can be injected into the inner wall of the human body cavity, such as the tissue of the intestinal wall.

The invention belongs to the technical field of agricultural science, and particularly relates to a tissue slice manufacturing method capable of measuring the thickness of a mucus layer of a pig intestinal tract. The operation process is simple, the damage to tissues is small, and the detection of the intestinal mucous layer of an animal with a larger enteric cavity can be realized. The core technology capable of observing the mucous layer is to ensure that chyme is not separated from the intestinal wall in the section manufacturing link, the traditional paraffin section technology is tedious in operation process and comprises dehydration, transparency and wax immersion, and the frozen section directly enters the section link, so that the separation of chyme and intestinal wall tissues caused by treatment such as ethanol gradient dehydration and high-temperature wax immersion is avoided, and the operation process is simplified. And the sample is not easy to cut in a slicing link, and a mucus layer is not easy to separate, break or lose after dyeing. The frozen section can directly freeze chyme and intestinal tissues without damaging a mucus layer between the chyme and the intestinal tissues, so that a complete mucus layer is obtained.