368 results about "Intestinal walls" patented technology

The invention discloses a sandwiched stapler type alimentary tract anastomosis dissecting sealer, relating to the surgical instruments. The invention provides a sandwiched stapler type alimentary tract anastomosis dissecting sealer which can prevent the alimentary tract anastomotic stoma from tearing, leaking and errhysis from the cut section in surgical operations. The sandwiched stapler type alimentary tract anastomosis dissecting sealer is provided with a nail anvil (which is also called as a bottom needle holder), a nail cartridge (which is also called as a nail anvil box), a sealer body, a movable handle, an adjusting button, a cutter cushion and an anastomosing nail (which is also called as a suturing nail), wherein the nail anvil is connected with the front end of the sealer body, the adjusting button is arranged at the tail part of the sealer body, the movable handle is arranged at the back of the sealer body, a safety button is arranged at the connection of the movable handle and the sealer body, the cutter cushion is arranged on the nail anvil, the anastomosing nail is arranged at the front end part of the sealer body, a membrane is arranged on the surface of the nail anvil (which is also called as the bottom needle holder), and a membrane is also arranged on the surface of the nail cartridge (which is also called as the nail anvil box); and after stapling, a sandwich structure consisting of the membrane, an intestinal wall and the membrane is formed.

A novel approach to diagnostic and therapeutic interventions in the peritoneal cavity is described. More specifically, a technique for accessing the peritoneal cavity via the wall of the digestive tract is provided so that examination of and / or a surgical procedure in the peritoneal cavity can be conducted via the wall of the digestive tract with the use of a flexible endoscope. As presently proposed, the technique is particularly adapted to transgastric peritoneoscopy. However, access in addition or in the alternative through the intestinal wall is contemplated and described as well. Transgastric and / or transintestinal peritoneoscopy will have an excellent cosmetic result as there are no incisions in the abdominal wall and no potential for visible post-surgical scars or hernias.

A novel approach to diagnostic and therapeutic interventions in the peritoneal cavity is described. More specifically, a technique for accessing the peritoneal cavity via the wall of the digestive tract is provided so that examination of and / or a surgical procedure in the peritoneal cavity can be conducted via the wall of the digestive tract with the use of a flexible endoscope. As presently proposed, the technique is particularly adapted to transgastric peritoneoscopy. However, access in addition or in the alternative through the intestinal wall is contemplated and described as well. Transgastric and / or transintestinal peritoneoscopy will have an excellent cosmetic result as there are no incisions in the abdominal wall and no potential for visible post-surgical scars or hernias.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and / or degraded within the GI tract.

A novel approach to diagnostic and therapeutic interventions in the peritoneal cavity is described. More specifically, a technique for accessing the peritoneal cavity via the wall of the digestive tract is provided so that examination of and / or a surgical procedure in the peritoneal cavity can be conducted via the wall of the digestive tract with the use of a flexible endoscope. As presently proposed, the technique is particularly adapted to transgastric peritoneoscopy. However, access in addition or in the alternative through the intestinal wall is contemplated and described as well. Transgastric and / or transintestinal peritoneoscopy will have an excellent cosmetic result as there are no incisions in the abdominal wall and no potential for visible post-surgical scars or hernias.

A method and apparatus are disclosed for treating obesity includes an artificial fistula created between gastrointestinal organs such as between the stomach and the colon. The method includes selecting an implant comprising a passageway having an internal lumen with an inlet end and an outlet end. The passageway is positioned passing through a first wall of first gastrointestinal organ (for example, passing through the wall of the stomach) and a second wall of a second gastrointestinal organ (for example, passing through the wall of the large intestine) with the inlet end disposed within an interior of the first gastrointestinal organ and with the outlet disposed within an interior of the second gastrointestinal organ.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and / or degraded within the GI tract.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and / or degraded within the GI tract.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and / or degraded within the GI tract.

The present invention relates to a paclitaxel composition and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4 to 90% by weight of at least one selected from the monoglycerides, 0.01 to 90% by weight of at least one oil and 0.01 to 20% by weight of paclitaxel. Also the present invention relates to a paclitaxel composition including emulsifiers and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4 to 90% by weight of at least one selected from the monoglycerides, 0.01 to 90% by weight of at least one emulsifier and 0.01 to 20% by weight of paclitaxel. The composition of the present invention is an effective paclitaxel delivery system since the composition solubilizes paclitaxel, does not form aggregates after being dispersed in water, adsorbs well on the intestinal wall, and therefore has high bioavailability.

In a region where an intestine is movable in the abdominal cavity, conventional endoscope apparatus have suffered from a difficulty in moving an endoscope advancing portion toward a deep intestinal portion. An apparatus for advancing an endoscope is provided, which can be easily manipulated to advance medical instruments having endoscopic functions toward a deep portion. The apparatus includes first and second medical instruments, each having, at a distal end portion thereof, a balloon portion that can be fixed to an intestinal wall. In a fixed state, the balloon portion of the first medical instrument is configured to form a gap for enabling a distal end portion of the second medical instrument to advance therethrough. In a fixed state, the balloon portion of the second medical instrument is configured to form a gap for enabling a distal end portion of the first medical instrument to advance therethrough.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to an actuator having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and / or degraded within the GI tract.

The invention discloses a complex enzyme preparation for feeding piglets. The complex enzyme preparation for feeding piglets comprises the following seven enzymes: acid protease, amylase, xylanase, beta-glucanase, cellulase, pectinase and phytase; and the enzymatic activity ratio of the seven enzymes is 1: 1: (8-10): (3.3-4): 1: (0.5-0.55): (0-0.02). By applying the complex enzyme preparation disclosed by the invention, various anti-nutritional factors in feed can be degraded, the viscosity of chyme in an intestinal tract can be reduced, and the metabolic energy of the feed can be improved; the protein and starch digestibility of the piglets can be improved; excessive reproduction of harmful microorganisms in the intestinal tract can be reduced, damage to the intestinal wall can be reduced, and the microecological balance of the intestinal tract can be regulated; the survival rate and disease resistance of the piglets can be improved, the diarrhea rate can be reduced, and the overall uniformity is improved; and the weight gaining of the piglets can be promoted, and the cultivation cost is reduced.

Embodiments of the invention provide swallowable devices, formulations and methods for the delivery of pharmaceutical and other therapeutic agents within the gastrointestinal tract. Some embodiments provide swallowable devices, such as capsules, for delivering agents into the intestinal wall or other lumens of the gastrointestinal tract. The device includes a capsule sized to be swallowed and passed through the intestinal tract. The capsule may include at least one catheter, one or more tissue penetrating members located in the catheter, a delivery member, an actuation mechanism, and a release element. The release element degrades upon exposure to various conditions in the gut to release and actuate the actuation mechanism. Embodiments of the invention are particularly useful for the delivery of pharmaceutical agents that are poorly absorbed, poorly tolerated, and / or degrade in the gastrointestinal tract.

Systems and methods are provided for motion detection and capture control of video data from a capsule camera system having an on-board storage. The capsule camera system moves through the GI tract under the action of peristalsis and records images of the intestinal walls. The capsule's movement is episodic and jerky. The capacity of the on-board storage is limited. In order to avoid unnecessary capture of images when the capsule camera moves very slowly or stalls, motion detection technique is utilized to help control image capture. Furthermore, an adaptive capture control is disclosed that automatically adjusts the threshold level of capture control to maintain proper image capture. The invented capture control also conserves precious battery power by eliminating capture of unnecessary images when the capsule camera moves too slowly or stalls. The present invention of image capture control and threshold update is also applicable to a capsule camera system having a wireless transmitter instead of an on-board storage.

The present invention relates to a paclitaxel composition and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4˜90% by weight of at least one selected from the monoglycerides, 0.01˜90% by weight of at least one oil and 0.01˜20% by weight of paclitaxel. Also the present invention relates to a paclitaxel composition including emulsifiers and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4˜90% by weight of at least one selected from the monoglycerides, 0.01˜90% by weight of at least one oil, 0.01˜90% by weight of at least one emulsifier and 0.01˜20% by weight of paclitaxel. The composition of the present invention is an effective paclitaxel delivery system since the composition solubilizes paclitaxel, does not form aggregates after being dispersed in water, adsorbs well on the intestinal wall, and therefore has high bioavailability.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to an actuator having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and / or degraded within the GI tract.

Embodiments of the invention provide shaped masses comprising one or more drugs such as proteins or polypeptides and methods for forming such shaped masses. One embodiment provides a shaped mass comprising a drug such as a protein or polypeptide having a biological activity in the body of a mammal. The shaped mass is formed by compression of a precursor material comprising the drug wherein an amount of biologically active drug in the mass is a preserved above a minimum level. Drugs which may be incorporated into the shaped mass may include one or more glucose regulating proteins such as insulin, incretins; and immunoglobulins such as TNF-inhibiting antibodies or interleukin neutralizing antibodies. Embodiments of the shaped mass may be incorporated into a tissue penetrating member which is inserted into the intestinal wall allowing for the oral delivery of proteins and peptides which would otherwise be degraded in the intestinal tract.

Embodiments provide devices, preparations and methods for delivering therapeutic agents (TAs) such as clotting factors (CFs, e.g., Factor 8) within the GI tract. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations configured to be contained within the capsule, advanced from the capsule into the IW and / or surrounding tissue (ST) and degrade to release the TA into the bloodstream to produce a therapeutic effect (e.g., improved clotting). The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW or ST (e.g., the peritoneal cavity). Embodiments are particularly useful for delivery of CFs for treatment of clotting disorders (e.g., hemophilia) where such CFs are poorly absorbed and / or degraded within the GI tract.

The invention discloses a method and a system for processing images based on photographing in vivo by a wireless capsule endoscopy or a video endoscope. The method comprise the following steps of: (1) continuously capturing two-dimensional reversed images of an intestinal canal inner wall through a reversed projection of a image sensor of the wireless capsule endoscopy or the video endoscope to the intestinal wall, and sending the two-dimensional reversed images with continuous sequences by a wireless sending device of the wireless capsule endoscopy or the video endoscope to an image processing device for storage; (2) identifying a superposition part of the continuous sequences of the two-dimensional reversed images obtained from the step (1) by the image processing device; and (3) cutting and splicing the superposition part of the continuous sequences of the reversed images by the image processing device to form a three-dimensional image which presents the whole intestinal canal inner wall. The method can reduce time on studying photographed images by medical workers and greatly improve diagnosis efficiency.

Embodiments of the invention provide shaped masses comprising one or more drugs such as proteins or polypeptides and methods for forming such shaped masses. One embodiment provides a shaped mass comprising a drug such as a protein or polypeptide having a biological activity in the body of a mammal. The shaped mass is formed by compression of a precursor material comprising the drug wherein an amount of biologically active drug in the mass is a preserved above a minimum level. Drugs which may be incorporated into the shaped mass may include one or more glucose regulating proteins such as insulin, incretins; and immunoglobulins such as TNF-inhibiting antibodies or interleukin neutralizing antibodies. Embodiments of the shaped mass may be incorporated into a tissue penetrating member which is inserted into the intestinal wall allowing for the oral delivery of proteins and peptides which would otherwise be degraded in the intestinal tract.

The invention claims a special primer for aided-identifying strains of lactobacillus and the application thereof. The special primer is composed of a primer pair A and a primer pair B; the primer pair A is composed of the DNA of the sequences 13 and 14 in the sequence table; and the primer pair B is composed of the DNA of the sequences 15 and 16 in the sequence table. The PCR amplification is carried out on the total DNA of the strain to be detected by using the special primer; if the PCR product can be amplified by the primer pair A or the primer pair B, the strain to be detected is the candidate strain of lactobacillus; if no PCR product is amplified by the primer pair A or the primer pair B, the strain to be detected is the candidate strain of non-lactobacillus. In combination with the denaturing gradient gel electrophoresis (DGGE) or the sequencing technology, the invention further determines that the strain to be detected is the specific strain of lactobacillus. By adopting the special primer of the invention and combining with the PCR and the DGGE, the planting condition of the probiotics on the intestinal wall of aquatic animal can be directly identified. The method is the fastest, simplest, most convenient and effective method at present.

Embodiments of the invention provide shaped masses comprising one or more drugs such as proteins or polypeptides and methods for forming such shaped masses. One embodiment provides a shaped mass comprising a drug such as a protein or polypeptide having a biological activity in the body of a mammal. The shaped mass is formed by compression of a precursor material comprising the drug wherein an amount of biologically active drug in the mass is a preserved above a minimum level. Drugs which may be incorporated into the shaped mass may include one or more glucose regulating proteins such as insulin, incretins; and immunoglobulins such as TNF-inhibiting antibodies or interleukin neutralizing antibodies. Embodiments of the shaped mass may be incorporated into a tissue penetrating member which is inserted into the intestinal wall allowing for the oral delivery of proteins and peptides which would otherwise be degraded in the intestinal tract.

The invention relates to a health-care food, and particularly provides health-care probiotics powder for intestinal tracts. The health-care probiotics powder is prepared from the following raw materials in parts by weight: 2-15 parts of bifidobacterium longum, 5-18 parts of saliva bacterium lacticum, 5-18 parts of bifidobacterium bifidum, 5-20 parts of bifidobacterium lactis, 2-15 parts of streptococcus thermophilus, 5-15 parts of lactobacillus bulgaricus, 2-18 parts of lactobacillus plantarum, 3-18 parts of lactobacillus acidophilus, 3-12 parts of microcrystalline cellulose, 2-18 parts of dietary fibers, 4-18 parts of ferment powder, 2-8 parts of xylooligosaccharide, 2-9 parts of citric acid and 2-12 parts of sorbitol, wherein the ferment powder is prepared from the following raw materials of pineapples, tomatoes, lemons, blueberries, cyclodextrine and microzymes. The invention further provides a preparation method of the health-care probiotics powder for intestinal tracts. The growth and the propagation of harmful bacteria can be restrained, the immune competence of bodies can be strengthened, the squirm of the intestinal tracts can be accelerated, the situation that excrement and urine are discharged out of bodies as soon as possible is urged, the stimulation of harmful toxins to intestinal walls is reduced, intestinal flora is regulated, and the purpose of alleviating constipation for a long term can be achieved; and in addition, the blueberries are also added, so that the health-care probiotics powder can improve eyesight.

Embodiments of the invention provide shaped masses comprising one or more drugs such as proteins or polypeptides and methods for forming such shaped masses. One embodiment provides a shaped mass comprising a drug such as a protein or polypeptide having a biological activity in the body of a mammal. The shaped mass is formed by compression of a precursor material comprising the drug wherein an amount of biologically active drug in the mass is a preserved above a minimum level. Drugs which may be incorporated into the shaped mass may include one or more glucose regulating proteins such as insulin, incretins; and immunoglobulins such as TNF-inhibiting antibodies or interleukin neutralizing antibodies. Embodiments of the shaped mass may be incorporated into a tissue penetrating member which is inserted into the intestinal wall allowing for the oral delivery of proteins and peptides which would otherwise be degraded in the intestinal tract.

The invention relates to a liquid forage and the preparation method, which comprises the following components in weight percentage: corn 20 to 60 percent, puffing soybean 15 to 50 percent, whey powder 2 to 15 percent, blood plasma protein 1 to 10 percent, fish meal 2 to 15 percent, treacle 1 to 7 percent, soybean oil 1 to 5 percent , CaHPO4 0.1 to 2 percent, stone powder 0.1 to 1 percent, NaCl 0.1 to 2 percent, choline 0.1 to 1 percent, L-Lys (L- lysine salt) 0.1 to 1 percent, DL-Met (methionine) 0.1 to 1 percent, pre-mixture 1.00 to 4.00 percent, and deflocculant 0.1 to 2 percent. Compared with the dry forage, the invention enhances the food intake of weaned newborn pigs; the invention also increases the feeding speed; the liquid forage can avoid the damages of dry forage to the intestinal wall morphology of weaned newborn pigs; liquid forage is beneficial to the inner environment of the digestive canal of newborn pigs; the enhancement of growing performance of early weaning newborn pigs can also be gained from the increase of ADFI, and simultaneously low pH value is also helpful to the protein digestion in the stomach of newborn pigs. The invention has the advantages of the regulation of the growing performance, the influence on the immunity function, and the balance of intestinal microbiological flora of early isolated weaning newborn pigs to reduce the cultivation cost greatly.

Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods.

The invention provides an intelligent vibrating electronic capsule. The electronic capsule comprises a shell, a vibrating module, a power module and a control module, wherein the vibrating module, the power module and the control module are arranged in the shell; the power module supplies electric energy to the vibrating module and the control module; the vibrating module can vibrate to make the electronic capsule vibrate; the control module comprises a microcontroller and a detector for automatically detecting the intestinal tract peristalsis speed; the microcontroller controls start and stop of the vibrating module and controls the vibrating frequency of the vibrating module according to the intestinal tract peristalsis speed detected through the detector. The intelligent vibrating electronic capsule can vibrate in a reciprocating mode in the human intestinal tract, dynamically detect the peristalsis condition of the intestinal tract and control the vibrating frequency according to the peristalsis condition of the intestinal tract; the intestinal wall is stimulated by vibration, acceleration of intestinal tract peristalsis is promoted, and therefore symptoms of slow transit constipation are relieved.