166 results about "Intestinal walls" patented technology

The invention relates to the field of ulcerative colitis, and discloses a multi-parameter monitoring system for evaluating the intestinal barrier function of ulcerative colitis, which is used for realizing the goal of automatically adjusting a treatment scheme according to a monitoring result by constructing a closed-loop feedback treatment system. According to the invention, by designing the nanoprobe of which the surface is modified with a specific binding element and combining with a swallowing capsule endoscopy, real-time imaging and molecular level dynamic tracking of the intestinal barrier are realized, genetically engineered bacteria are constructed to quantify intestinal permeability abnormality and local inflammation level, and an intestinal barrier function damage score and a disease progress prediction result are output; individual monitoring is achieved through transfer learning, ultrasonic elastography, optical coherence tomography, wearable equipment for measuring intestinal electric field impedance spectroscopy and other technologies are adopted, an intestinal wall mechanics-electrophysiology composite parameter set is obtained, and the evaluation accuracy is improved.

The invention relates to the technical field of image focus detection, in particular to a fiber endoscope image focus detection method and system, and the method comprises the following steps: providing a data quality guide interface; capturing narrow-band light images of the endoscope away from a first preset position and a second preset position of the intestinal wall in the axial movement process, calculating brightness gain values of a blue light channel and a green light channel, calculating an asymmetric scattering correction coefficient, and updating indication of color information calibration integrity; tracking the pixel moving speed of the interferent in the view in the propulsion operation process, calculating the relative depth of the interferent, and updating the indication of the validity of the depth data of the interference layer; identifying the image area which is not shielded by the interferent, and updating the indication of the information coverage degree of the background area; triggering an image synthesis operation; performing color compensation on the image information of the image area which is stored in the background canvas and is not shielded by the interferent; reconstructing a clear image; and performing focus detection on the clear image. The method improves the accuracy of focus detection.

The invention discloses an Ansys-based intestinal tract wall and wall surface motion modeling method and device. The method comprises the following steps: S1, establishing a human body real intestinal tract three-dimensional geometric model; s2, preprocessing the three-dimensional geometric model of the intestinal tract; s3, intestinal wall material parameters are set, and an intestinal wall is simulated; s4, separating a wall surface solid domain from the modified intestinal tract three-dimensional geometric model, carrying out wall surface simulation setting, and dividing grids; s5, by setting load and boundary conditions, wall surface movement setting is achieved in the form of simulating intestinal tract movement; wherein the motion forms comprise creeping, sectional contraction and swinging contraction; and S6, setting solver parameters, and simulating intestinal tract wall and wall surface movement. Loads and constraint conditions can be flexibly adjusted, the variability and adaptability of the model are remarkably enhanced, and the cost of sacrificing the real reflection capability of the model to the actual physiological state is not taken.

The utility model provides a tube with a sacculus and a sacculus auxiliary system, the tube with the sacculus comprises an outer tube and i sacculus sections arranged on the outer tube, and i is a positive integer; each balloon section comprises more than two balloons which are sequentially arranged along the axial direction of the outer tube; the radial size of the balloon along the outer tube is enlarged when the balloon is filled and is reduced when the balloon is emptied; the total number of the balloons in all the balloon sections is not less than 3; wherein in each balloon section, all the balloons are isolated from one another, and all the balloons are configured to form fluctuations transmitted in the axial direction of the outer tube through filling and emptying. According to the configuration, all the balloons in each balloon section are isolated from one another and are configured to form fluctuation transmitted in the axial direction of the outer tube through filling and emptying, so that the intestinal canals can be flexibly and efficiently nested, the nesting amplitude of the intestinal canals is small, and the risk of intestinal wall injury can be reduced. In addition, operation is easy and convenient, efficiency is high, and operation time can be shortened.

The invention relates to the technical field of data management, in particular to a self-service enema method and system based on intelligent proportioning, and the method comprises the following steps: collecting intestinal tract and physiological data, monitoring intestinal tract movement frequency, intestinal wall tension, instantaneous pressure, digestive juice secretion rate, heart rate and blood pressure in real time, removing abnormal data, and adjusting the data range. And forming a physiological parameter data set. According to the method, a refined data set is constructed by monitoring multiple physiological data in real time, so that the liquid medicine proportion better conforms to the individual characteristics, flow rate correction and pressure adjustment are introduced in the liquid medicine mixing process, it is ensured that the proportion is accurate and liquid medicine conveying is stable, and real-time pressure monitoring and excrement flow state analysis help to optimize the conveying rate and improve the liquid medicine absorption efficiency; the influence of individual difference is reduced, so that the accuracy and the effect of treatment are enhanced.

The invention relates to the technical field of image enhancement, and discloses an intestinal dynamic MRI image enhancement method and system based on deep learning, through the image enhancement method based on deep learning, the quality of a small intestine cine-MRI image is improved, the problems of low resolution and poor contrast of a traditional image are improved, and the identifiability of a small intestine intestinal wall structure is enhanced. On the basis, pixel-level registration processing of continuous frame images is combined, the intestinal segment movement track is accurately extracted, and movement parameters such as contraction frequency, lumen diameter variation amplitude, pixel displacement mean value and variance are calculated. Furthermore, a pre-training evaluation model is utilized to intelligently output a small intestine dynamic state judgment result based on motion parameters, and standardized auxiliary recognition of small intestine dynamic disorder diseases and severity of the small intestine dynamic disorder diseases is achieved. According to the method, the image processing quality, the motion feature extraction accuracy and the evaluation intelligence level of small intestine dynamic evaluation are integrally improved, and the method has important clinical application value and popularization significance.

The invention discloses a self-breaking outer drainage tube, and relates to the technical field of medical instruments, the self-breaking outer drainage tube comprises a tube body, and the tube body comprises a drainage part, a breaking part, a leading-out part and a puncture part; the drainage part and the fracture part are both made of degradable materials; the hole wall thickness of the circulation hole at the fracture part is smaller than the hole wall thickness of the circulation hole at the drainage part; during surgical operation, the degradable inner drainage part is placed in the pancreatic duct, the fracture part crosses the anastomotic stoma by 7-8 cm and crosses the biliary-intestinal anastomotic stoma, and the leading-out part walks in the enteric cavity to a proper position, penetrates out of the intestinal wall and is led out of the body through the abdominal wall. Cutting the puncture part to expose the outlet of the circulation hole, and discharging the body fluid through the circulation hole; after a certain period of time after the operation, the fracture part is automatically fractured under the action of pancreatic juice, the leading-out part is pulled out, the degradable drainage part continues to be degraded in the body and maintains the drainage function, and finally the drainage part is absorbed by the body or discharged out of the body without being taken out through the operation.

The utility model provides a self-discharging type double-helix biliary stent, and belongs to the technical field of medical drainage catheters. Comprising a stent body, and the stent body comprises a connecting pipe, a first spiral pipe and a second spiral pipe; the connecting pipe is used for fixedly connecting the first spiral pipe and the second spiral pipe; the first spiral tube is mounted on one side of the connecting tube and used for draining bile; the second spiral pipe is installed on the side, away from the first spiral pipe, of the connecting pipe. Compared with an existing double-pigtail stent or a self-discharging type biliary tract spiral stent, the spiral structure of the two sets of spiral tubes can better adapt to the physiological form of the biliary tract, stable fixation is formed, the risk that an original stent with one end being of a vertical structure possibly pierces the intestinal wall is avoided, and the intestinal tract can be more stably fixed. Due to the arrangement of the self-discharging double-helix biliary stent, convenience is provided for taking out the stent subsequently.

The invention relates to the field of medical apparatus and instruments in rectum surgery, and particularly provides a novel multifunctional intestinal bypass device for rectum surgery, which comprises a hollow sleeve, a film sleeve, a decompression air bag sleeved outside the hollow sleeve, and an inflation channel, wherein after being inflated, the decompression air bag protrudes in a corrugated or threaded mode in the axial direction of the hollow sleeve, the protruding part makes contact with the intestinal wall to provide friction force, and a decompression gap is formed between the sunken part and the intestinal wall; according to the invention, intestinal contents are discharged from the hollow sleeve and the film sleeve, so that excrement or intestinal juice is prevented from being in contact with an anastomotic stoma, the infection risk of the anastomotic stoma is reduced, and the healing rate of the anastomotic stoma is accelerated; the thin film sleeve is soft and deformable, so that discomfort such as anus falling expansion, pain and tenesmus of a patient can be effectively reduced, and the comfort of the patient is improved; the decompression air bag is expanded through the inflation channel, the hollow sleeve is positioned, meanwhile, blood supply of the intestinal wall is protected, and the reliable effect of replacing preventive fistulization is achieved.

The invention relates to the technical field of tumor risk assessment, in particular to an intestinal tumor risk assessment method based on image analysis, and the method comprises the steps: carrying out the continuous image division and parameter collection; identifying abnormal density image blocks; identifying concerned risk image blocks; judging a response risk image block; adjusting a preset synchronization degree risk threshold value; early warning judgment is carried out, and a serious early warning report is generated. According to the method, a self-adaptive and dynamically-adjusted three-level judgment system is established through real-time collaborative analysis of multi-dimensional parameters of an enteroscope image block, firstly, a suspected focus is locked based on the texture change duration, then, the focus characteristics are verified through vascular abnormality and contrast fluctuation depth, and finally, the accuracy of the focus is improved. And finally, the risk threshold is corrected in combination with intestinal wall peristalsis and the lens shielding degree, so that the problem of low early flat tumor recognition accuracy caused by insufficient flat tumor image feature capture due to excessive dependence on intestinal environment microorganism and metabolite biochemical detection is effectively solved.

Embodiments provide devices, preparations and methods for delivering therapeutic agents (TAs) such as clotting factors (CFs, e.g., Factor 8) within the GI tract. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations configured to be contained within the capsule, advanced from the capsule into the IW and / or surrounding tissue (ST) and degrade to release the TA into the bloodstream to produce a therapeutic effect (e.g., improved clotting). The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW or ST (e.g., the peritoneal cavity). Embodiments are particularly useful for delivery of CFs for treatment of clotting disorders (e.g., hemophilia) where such CFs are poorly absorbed and / or degraded within the GI tract.

The invention discloses a drug delivery device in a human body cavity, which comprises an inflatable balloon, at least one part of the outer wall of the balloon is provided with a protective shell, the balloon is provided with an inner cavity, and the protective shell can be dissolved by specific body fluid in the human body cavity; the triggering part is arranged in an inner cavity of the balloon, and the triggering part can react with body fluid to generate fluid to inflate the balloon when making contact with the body fluid, so that the inflated balloon is tightly attached to the wall of a body cavity; the propelling part is arranged in the inner cavity of the balloon and comprises a tissue penetrating component, and the triggering part can generate power to propel the tissue penetrating component; and the containing part is used for containing a medicine preparation, and the triggering part can push and press the liquid medicine preparation contained in the containing part into the pushing part after the balloon is inflated, and injects the liquid medicine preparation into the inner wall tissue of the human body cavity through the tissue penetrating component. By means of the device, macromolecular drugs or preparations can be injected into the inner wall of the human body cavity, such as the tissue of the intestinal wall.

The invention relates to biomedical engineering, and discloses a biochip screening method of a therapeutic agent based on intestinal brain axis regulation and application thereof. The screening method comprises the following steps: performing intestinal wall cell culture or microglial cell culture by adopting a metasurface plasmon resonance biochip of which the surface is subjected to bionic treatment to obtain an intestinal wall cell adherent chip board or a microglial cell adherent chip board; the method comprises the following steps: adding a culture medium containing a chemotherapeutic drug or lipopolysaccharide into a cell-adherent chip board for culture I, then removing the culture medium, adding a therapeutic agent to be detected for culture II to obtain a culture solution, and detecting the cell repair effect of intestinal wall cells or microglial cells in the culture solution, and screening to obtain a therapeutic agent with a repairing effect on intestinal wall cells and / or microglial cells. The screening method can be used for efficiently and accurately screening the therapeutic agent with dual effects of intestinal regulation and neuroprotection from a plurality of therapeutic agents to be detected, and can be used for dynamically monitoring and exploring the interaction condition of the therapeutic agent and cells on line in an unmarked and real-time manner.

The mouse intestinal tumor cell injector comprises a handle, an injection device installed in the handle, and a radially telescopic support ring structure connected with the handle, tumor cells can be discharged from a first injection needle by operating a first push rod, and antibiotics can be discharged from a second injection needle by operating a second push rod; when the support ring structure is in a contracted state, the first injection needle and the second injection needle are located in the support ring structure; when the support ring structure is in an expanded support state, the needle heads of the first injection needle and the second injection needle can both extend to the outside of the outer edge of the support ring structure and are inserted into the mouse intestinal wall. The present application supports the mouse intestine by the support ring structure, supports the insertion of the first injection needle and the second injection needle into the mouse intestinal wall, ensures that only the mouse intestinal endothelium is punctured and the mouse intestinal canal is not punctured, ensures that tumor cells are injected into the mouse intestinal wall, and when the tumor cells are injected, antibiotics are also injected for anti-inflammatory treatment, which is beneficial to the recovery of the mouse intestinal puncture point.

This invention discloses a capsule system for electro-adhesion in the digestive tract and its operating method, relating to the field of medical devices. The system includes a transparent outer shell forming a sealed cavity within it; multiple electrode adhesion units are axially arranged on the outer wall of the shell; an image acquisition device is fixed inside the shell, with its acquisition end adjacent to the transparent end of the shell; a wireless transmission device is used for bidirectional wireless data transmission with an external workstation; when the drug storage device's release port is open, the drug within the storage device can be released to the outside; a control module can control the opening and closing of the release port, and can control the power supply to the electrode adhesion units, as well as the direction of current flow after power is applied; a power supply is electrically connected to the image acquisition device, the wireless transmission device, the drug storage device, and the control module. The system and its operating method of this invention can save internal capsule space, avoid mechanical damage to intestinal wall tissue, and the anchoring and release process is rapid, controllable, and reversible.

The invention discloses an endoscopic positioning mark clamp, which comprises a clamp main body in a tubular shape, two axial ends of the clamp main body are respectively provided with a pipe orifice; the chuck is arranged at the front end of the clamp main body and is provided with a first arm and a second arm which are exposed out of the front end of the clamp main body and can be opened and closed; the head end of the inhaul cable is connected with the chuck in a detachable mode, the tail end of the inhaul cable extends backwards to the outside of the clamp body in the axial direction, and opening and closing of the first arm and the second arm can be operated; the magnetic block is arranged in the clamp main body; the rope loop is arranged at the rear end of the clamp main body; the clamp body, the clamping head, the inhaul cable and the rope loop are all made of non-magnetic materials. According to the positioning marking clamp under the endoscope, the clamp can be clamped to the intestinal wall tissue through the endoscope clamp channel, the distance between the magnetic block and the intestinal wall tissue is short, and an iron surgical instrument outside the intestinal wall tissue can more conveniently detect the position of the magnetic block.

A double-needle bidirectional barb surgical suture with a buckle ring in the middle comprises a single suture, suture needles are arranged at two ends of the suture, barb suture bodies on two sides of the suture are respectively provided with barbs with barbs pointing to the middle, the buckle ring is arranged in the middle of the barb suture bodies, and the barb suture bodies are made of absorbable materials. After the sutured first needle is used for suturing the tissue, the suture needle on one side penetrates into the buckling ring and then is tensioned, so that the first needle is used for suturing the tissue and is locked, and tissue damage caused by excessive traction of the barb line on the other side of the buckling ring towards the barb opening direction in the traction process when the suture needles on the two sides are continuously used for suturing the tissue subsequently can be avoided; by means of the device, the suture line can be conveniently pulled to twist the intestinal canal in the surgical anastomosis operation process of the gastrointestinal tract, so that an operation operator can conveniently suture the lateral and dorsal intestinal walls, and the gastrointestinal tract operation, especially the gastrointestinal tract anastomosis under a laparoscope, can be facilitated.

The invention relates to the technical field of medical instruments, in particular to an enteric cavity segment filling controllable device for colon cancer preoperative T staging, which comprises a central mandrel, a flexible head end cap is arranged at the foremost end of the central mandrel, and a near-end balloon inflating pipeline, a far-end balloon inflating pipeline and a main pipeline which are mutually independent are arranged in the central mandrel; the near-end balloon is arranged on the central mandrel in a sleeving manner and is communicated with the near-end balloon inflating pipeline; the far-end balloon is arranged on the central mandrel in a sleeving manner, is positioned on the far side of the near-end balloon and is communicated with the far-end balloon inflating pipeline; at least two main pipeline lateral holes are formed in the tube wall of the central mandrel between the near-end balloon and the far-end balloon, are communicated with the main pipeline and are used for injecting a contrast agent or normal saline into the closed enteric cavity section between the two balloons. The near-end balloon and the far-end balloon are synchronously filled at the two ends of a target intestinal segment to form a closed segment, and a contrast agent is uniformly injected through lateral opening, so that the intestinal wall is fully expanded and does not collapse, and the display definition of the five-layer structure of the intestinal wall is remarkably improved.

The invention belongs to the technical field of medical instruments, and discloses a gastrointestinal tract magnetic clipping fistulization assembly and application thereof. The assembly comprises at least two magnetic bodies, each magnetic body is provided with a clamping end face, the effective length of each clamping end face is 3-5 cm, the width of each clamping end face is not smaller than 0.2 cm, and a clamping gap of 2-4 mm is formed between the stomach wall and the intestinal wall when the two magnetic bodies are attracted. The assembly can adopt an integral structure, a split structure, a bendable structure or a concave-convex clamping structure, and the magnetic body is provided with a fixing structure and a guide assembly. Laparotomy and minimally invasive implantation are not needed, permanent foreign matter residues are avoided, a stable permanent anastomosis channel can be formed, the risk of complications such as adhesion and leakage is reduced, the device is suitable for patients with refractory digestive tract obstruction, and fistulization safety and success rate are improved.

Disclosed herein is the use of a catheter for isolating a region within a hollow organ of a mammal for the treatment of esophageal or enteric hemorrhage, for the treatment of esophageal wall fistula or perforation, for the treatment of intestinal wall fistula or perforation, for the treatment, severity assessment, prognosis and monitoring of acute pancreatitis, and for the treatment, severity assessment, prognosis and monitoring of acute pancreatitis. And for the treatment of intestinal wall injury. The used catheter at least comprises a body in a long and thin shape; the two inflatable balloons are arranged along the body; the functional channel extends in the body and comprises a functional opening formed in the portion, between the balloons, of the body; the second channel extends in the body, an inlet and an outlet are formed in the two ends of the second channel respectively, and the inlet and the outlet are both formed in the portion, defined by the balloon, of the body in the external area of the isolated organ.

The invention relates to a magnetic control self-conformal intestinal stent and a dynamic monitoring system, and belongs to the technical field of medical instruments, and the magnetic control self-conformal intestinal stent comprises a biodegradable main skeleton, a magnetic driving unit, a pressure sensing array and an in-vitro control device. A magnetic response material is embedded into the main framework, and form regulation and control and degradation rate control are realized through an in-vitro magnetic field; the flexible sensing array monitors intestinal wall pressure in real time, and the self-adaptive structure is linked to dynamically adapt to the intestinal tract curved surface. The in-vitro device integrates magnetic field adjustment and data processing, and supports precise positioning of the support and intelligent adjustment of the attaching force. The system improves the stability in a complex intestinal environment through magnetic coupling driving and multi-mode monitoring, early warns abnormal risks in real time, and avoids the rigid defect and monitoring lag problems of a traditional stent. The biodegradable material is combined with intelligent control, the degradation process and tissue repair are synchronized, a safe and effective treatment scheme is provided for diseases such as intestinal obstruction, and the treatment effect of a patient is improved.

The present disclosure relates to the field of drug delivery, in particular, the present disclosure relates to a microneedle drug delivery device and a preparation method thereof. The device comprises a substrate, a microneedle array and a liquid-absorbing swelling material, the substrate carries the microneedle array, and the liquid-absorbing swelling material is arranged between the substrates to form a sandwich structure. The device uses a mild water-absorbing swelling mechanism and the natural peristalsis of the gastrointestinal tract to pierce the microneedles into the intestinal wall, complete drug delivery, physically break through the physiological barrier of oral delivery and absorption of biological drugs, and improve the oral bioavailability of biological drugs. The materials used are all biodegradable soft materials, which are safe.

Provided is a medical support device including a processor. The processor is configured to specify a papilla type, which is a type of a duodenal papilla, by executing image recognition processing on an intestinal wall image obtained by imaging an intestinal wall including the duodenal papilla in a duodenum with a camera provided in an endoscope scope; and output related information related to the papilla type.

The invention relates to the technical field of artificial intelligence, and provides an eosinophilic gastroenteritis typing system and method based on multi-modal data, and the method comprises the steps: obtaining a digestive endoscopy image, an ultrasonic endoscopy image, a CT examination image and clinical manifestation data of a to-be-detected person collected in the same time period; the gastrointestinal mucosa lesion state is recognized through a digestive endoscopy image and is represented by numerical features; identifying the abnormal thickening condition of each film layer structure of the gastrointestinal wall through an ultrasonic endoscope image, and representing the abnormal thickening condition by numerical features; lesion hierarchical distribution is judged through an ultrasonic endoscope image, and numerical feature representation is carried out; determining seroperitoneum and intestinal wall thickening conditions through a CT examination image, and performing numerical characteristic representation on the seroperitoneum and intestinal wall thickening conditions; clinical symptom features are obtained through the clinical manifestation data and are represented by numerical features; generating a feature vector based on multi-modal data by using each numerical value feature representation; and inputting the feature vectors into a dynamic typing prediction model to realize the typing prediction of eosinophilic gastroenteritis, thereby improving the accuracy of auxiliary diagnosis and evaluation.

The invention relates to an operation device, in particular to a portable anorectal operation auxiliary device which comprises a handheld gun handle, a gun barrel and an exploring tube, the hollow gun barrel is connected to the front end of the handheld gun handle, a guide hole is horizontally formed in the upper portion of the handheld gun handle, the front end of the guide hole is communicated with an opening in the rear end of the gun barrel, and the exploring tube can slide into the gun barrel through the guide hole. The front end of the exploring tube is connected with a probe. In the aspect of cleaning the camera, the water pipe and the annular nozzle are arranged at the position of the probe, when the device is externally connected with a water source, water flows through the water pipe and is evenly sprayed out of the annular nozzle, the camera can be cleaned in time, intestinal wall mucus or dirt interference of a patient is avoided, clear imaging is guaranteed, operation cleaning does not need to be interrupted, and medical operation efficiency is greatly improved. Meanwhile, the device is provided with a distraction mechanism, the closed probe can be protected, friction damage between the closed probe and the intestinal wall is reduced, the internal space can be slightly distraction and expanded according to the anorectal condition of a patient, the passing rate of the probe is increased, convenient conditions are created for subsequent medical operation, and the device has practicability and innovativeness.

The invention relates to a system for intestinal delivery of therapeutic agents. Described herein are systems for enteric delivery of therapeutic agents, and methods of administering therapeutic agents to a patient by oral administration of an enteric delivery system. An intestinal delivery system includes one or more carrier members comprising a carrier polymer and a therapeutic agent, and the system may be configured in a compressed configuration and an expanded configuration, and sized to maintain contact with an intestinal wall of a small intestine by applying an outward pressure to the intestinal wall, and transporting at least a portion of the therapeutic agent across the intestinal mucosa of the small intestine.

The present invention discloses an intestinal flow field modeling method and device based on bidirectional fluid-solid coupling. The method comprises: S1, collecting intestinal multimodal data; wherein the multimodal data includes geometric parameters, motion characteristics, content statistics and wall stress and strain data of the intestine; S2, reconstructing a three-dimensional geometric model of the human intestine; S3, preprocessing the established intestinal geometric model by format conversion and simplification and modification; S4, dividing the preprocessed model into a fluid domain and a solid domain, and establishing a bidirectional fluid-solid coupling model architecture; S5, performing fluid domain simulation settings: simulating multiphase flow contents and setting a fluid simulation model; S6, performing solid domain simulation settings: setting intestinal wall material parameters and simulating intestinal movement; S7, achieving bidirectional fluid-solid coupling and simulating the intestinal flow field. The method takes into account the bidirectional interaction between the intestinal wall solid domain and the intestinal content fluid domain, achieving more accurate intestinal flow field simulation.

The application belongs to the technical field of medical devices, and particularly relates to a kind of cryoablation catheter and ablation system, the cryoablation catheter includes inner catheter and outer catheter, the outer catheter is coaxially sleeved on the outside of inner catheter, the inner catheter is configured as a multi-lumen structure, further comprising: a plurality of sealing components, a plurality of the sealing components are arranged on the outside of inner catheter;Wherein, in the initial state, a plurality of the sealing components and inner catheter are located in the inside of outer catheter, in the working state, a plurality of the sealing components and intestinal wall form an ablation closed space together. The application guides the cryoablation catheter to the target position through the guide wire, forms the ablation closed space through the cooperation of sealing components and lumen wall, inputs the cryogenic medium into the ablation closed space to freeze and ablate the lumen wall, provides a usable treatment plan for type 2 diabetes, obesity or other lumen lesion patients, and has the advantages of small trauma, less pain for patients, low surgical risk, etc.

The invention discloses a drug delivery device in a human body cavity, which comprises an inflatable balloon, at least one part of the outer wall of the balloon is provided with a protective shell, the balloon is provided with an inner cavity, and the protective shell can be dissolved by specific body fluid in the human body cavity; the triggering part is arranged in an inner cavity of the balloon, and the triggering part can react with body fluid to generate fluid to inflate the balloon when making contact with the body fluid, so that the inflated balloon is tightly attached to the wall of a body cavity; the propelling part is arranged in the inner cavity of the balloon and comprises a tissue penetrating component, and the triggering part can generate power to propel the tissue penetrating component; and the containing part is used for containing a medicine preparation, and the triggering part can push and press the liquid medicine preparation contained in the containing part into the pushing part after the balloon is inflated, and injects the liquid medicine preparation into the inner wall tissue of the human body cavity through the tissue penetrating component. By means of the device, macromolecular drugs or preparations can be injected into the inner wall of the human body cavity, such as the tissue of the intestinal wall.

The invention relates to an enteroscope navigation method based on entry image features, in particular to an enteroscope navigation method based on entry image features. The objective of the invention is to solve the problem of low accuracy of forward direction prediction and safe distance discrimination of an existing enteroscope navigation method. The invention provides a Vision Transform-based enteroscope image direction prediction model, pre-training of unlabeled data is carried out in combination with self-supervised learning, and prediction and visual labeling of the forward direction of an enteroscope are realized through supervised fine tuning. The method comprises the following steps: firstly, carrying out self-supervised learning by utilizing a large number of unmarked enteroscopy images to reconstruct tasks to obtain efficient visual representation, so as to learn intestinal anatomical structure features; subsequently, supervised fine adjustment is performed on a small amount of labeled data, so that the accuracy of prediction of the forward direction of the enteroscope and judgment of the distance between the lens and the intestinal wall is improved. The method is applied to the field of enteroscope navigation.