75 results about "Biliary stent" patented technology

A stent delivery system and method for positioning a first and second stent in the main lumen and the first and second branch lumens of a bifurcation.

A biliary stent has a number of smooth-surfaced wings extending radially outwardly from a central region and extending longitudinally along substantially the entire length of the stent. A securement barb is located at one end of the stent and extends generally radially outwardly toward a side of the stent in cantilevered fashion at an angle less than or equal to 90°. The securement barb is angled such that it presents an outward-facing half-arrowhead profile. At least one end of the stent is smoothly or conically tapered. In one embodiment, the wings extend linearly along the stent; in another embodiment, the wings extend helically along the stent. Either embodiment may have a pigtail configuration at one or both ends.

An inflatable stent is provided for placement within the biliary duct to facilitate drainage therethrough and maintain the patency of the duct. The biliary stent includes a tubular member, an inflatable reservoir and a port located at a proximal portion of the tubular member. The tubular member has interior and exterior surfaces and an inflatable reservoir disposed circumferentially between the interior and exterior surfaces. An inflation fluid, such as a liquid or gas, may be inserted through the port and contained within the inflatable reservoir to expand the diameter of the biliary stent. The biliary stent may be removed from the patient by deflating the inflatable reservoir and using a removal device such as a forceps or snare.

The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents generally and a biliary stent in particular where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to radial forces. An exemplary embodiment also provides a family of stents with novel interstice configurations that facilitate flexibility, durability and/or proper installation. Additionally, the biliary stent in accordance with the present invention provides enhanced flow mechanics to ensure the adequate clearance of viscid fluids such as bile.

A delivery device for a biliary stent constructed of thermoplastic material with ridges and valleys formed along the outer surface of the stent that provide a helical, thread-like configuration. The delivery device comprises an external surface that is selectively expandable to engage an interior surface of the tubular stent. Additionally the exterior surface may include ridges and valleys that coincide with ridges and valleys defined by the helical thread extending through the stent in order to provide a more secure engagement with the stent during delivery.

The invention discloses a medicine-carrying nanofiber membrane biliary stent and a preparation method thereof. The medicine-carrying nanofiber membrane biliary stent comprises one part of nanofiber inner layers, the other part of nanofiber inner layers, a metal support and a medicine-carrying degraded fiber outer layer from inside to outside, wherein one part of nanofiber inner layers are arrayed in the pipe diameter direction, and the other part of nanofiber inner layers are arrayed disorderly. The nanofiber inner layers arrayed in the pipe diameter direction and the nanofiber inner layers arrayed disorderly are bonded together. The nanofiber inner layers arrayed disorderly and the medicine-carrying degraded fiber outer layer are boned together through meshes of the metal support, and the metal support is firmly fixed in a fiber membrane. The preparation method includes that electrostatic spinning equipment is adopted for electrostatic spinning. Compared with a micro-nano ball, the nanofiber membrane biliary stent has better structural stability, can be used for treating biliary stricture caused by tumors, has a mechanical expansion effect and a local treatment function, and can solve the biliary malignant stricture better than a common stent or a membrane-covering stent. In addition, the method can be applied to gastrointestinal tract stents and tracheal stents.

The invention relates to a bile duct support and a preparation method thereof. The bile duct support is characterized in that non-woven films are electrostatically spinned on the inner wall and the outer wall of a meshy bile duct support knitted by using the present medical alloy silk to form a cladding structure for an alloy silk meshy bile duct support. Because the film adopts medical polyurethane with favorable biocompatibility and high elasticity, the biocompatibility of the bile duct support in the body is improved, and the high elasticity of the support is maintained. A function of hindering the bile flowing through the bile duct by the support alloy silk and stimulation to bile duct endothelial cells and bile duct smooth muscle cells in the bile duct caused by radially expanding the bile duct by the alloy silk are effectively eliminated, and the bile duct is avoided to become narrow again. The bile duct support has simple preparation method, convenient operation, low cost and favorable controllability on preparation of the inner film and the outer film of the bile duct, and the method is suitable for preparing bile ducts with various diameters and lengths.

A treatment device such as a biliary stent, capable of effectively and continuously inhibiting biofilm formation, and a biofilm formation inhibitor suitable for coating on the treatment device by killing all bacteria including E. coli and by suppressing the growth of these bacteria, are provided. A biofilm formation inhibitor having an effective amount of catechin for inhibiting biofilm formation and a carrier that is suitable for adhesion of said catechin to a treatment device to be placed in the living body, are provided.

The invention discloses a degradable biliary duct drug-eluting stent, which consists of a biliary duct stent body and a biodegradable high-molecular polymer coating arranged on the surface of the biliary duct stent body. The biliary duct stent body is formed by mixed braiding of biodegradable metal wires and biodegradable high-molecular material silk threads. The biliary duct stent body is of a tubular structure. The two ends of the biliary duct stent body are shaped like trumpets that are open outwardly. The surface of the biliary duct stent body is a netted surface. The biodegradable high-molecular polymer coating carries drugs. The degradable biliary duct drug-eluting stent plays a mechanical supporting effect in a short period, is completely degraded after a treatment effect disappears, prevents tube wall tissues from being stimulated for a long period of time, effectively prevents the wall tissues from narrowing again after an operation, enables drug loaded fiber films to evenly wrap the surface of the stent body, and makes the drugs release slowly.

The invention relates to the technical field of medical materials and provides a degradable biliary stent. The degradable biliary stent is a magnesium alloy degradable biliary stent. The magnesium alloy degradable biliary stent comprises a plurality of ring-shaped supporting parts distributed in the radial direction and used for radial supporting during ball expansion and a plurality of connectingparts distributed in the axial direction and used for axial connection with the adjacent ring-shaped supporting parts to form a net-like structure. The magnesium alloy degradable biliary stent replaces a non-degradable biliary stent, serves as a ball expansion stent to be implanted at the narrow part of biliary lesion and plays a drainage effect in a support, and the phenomenon can be avoided that the limitations of a stent tube cause complications or the non-degradable biliary stent is difficult to take out. Different from a covered stent, the stent is difficult to displace and has a wider lesion position application range. It is proved through animal experiments that the biliary tracts at the suture parts of experimented animals in an experimental group are smooth and free of biliary sludge or lithogenesis by applying the magnesium alloy degradable biliary stent, and the stent is completely degraded in the eighth week.

The present invention relates to a biliary tract interior support frame containing medicine and its preparation method. Said biliary tract interior support frame includes tubular supporting tube which can open cavitary tract of biliary duct and is equipped with several medicine-releasing holes. The inner wall of the invented tubular supporting tube has a layer of medicine-stored layer made up by mixing medicine and excipient. Several biliary tract interior suppert frames can be series-connected together. Said invention also provides the concrete steps of its preparation method.

The invention relates to an anti-regurgitation biliary stent which is provided with a stent body and side wings. The biliary stent is further provided with an anti-regurgitation valve which is in a nipple shape and provided with a fixing ring, a cannula and a capsule bag with a releasing crack. The fixing ring coordinates with an annular groove in the tail end of the stent body to enable the anti-regurgitation valve to be fixed to the stent body. The cross section of the groove is in an arc shape, and the central angle of the groove is 180-240 degrees. The releasing crack is in a Y shape or a cross shape. Due to the fact that the anti-regurgitation valve is arranged on the biliary stent, and the spherical capsule bag with the releasing crack is arranged on the anti-regurgitation valve, the phenomena of biliary intestinal regurgitation and biliary tract infection can be reduced, the unobstructed period of the plastic biliary stent can be prolonged possibly, and the survival quality of patients is improved greatly; the junction between the anti-regurgitation valve and the stent body is firm, and the anti-regurgitation valve is not prone to loosening and disengaging; the whole biliary stent is simple in structure, convenient to use and suitable for being popularized in clinic.

The invention discloses a magnesium alloy biliary stent and a preparation method thereof. The magnesium alloy biliary stent comprises an extensible magnesium alloy stent body, wherein small intestinemucous membrane lower-layer matrix layers are arranged on the inner wall and the outer wall of the magnesium alloy stent body. The preparation method comprises the following steps that the small intestine mucous membrane lower-layer matrix layers are prepared; the magnesium alloy stent body is pretreated to remove oxide on the surface of the stent body; electrolyte is prepared, wherein the magnesium alloy stent body is put in micro-arc oxidized electrolyte, the magnesium alloy stent body serves as an anode, and a stainless-steel electrolytic tank serves as a cathode to perform micro-arc oxidization treatment; a test sample is post-treated; the prepared small intestine mucous membrane lower-layer matrix layers are suture or bonded on the inner layer and the outer layer of the magnesium alloy stent body respectively to obtain the magnesium alloy biliary stent. The magnesium alloy biliary stent has good biocompatibility, can be biodegraded into a nontoxic product and has no immunogenicity.

The invention relates to a radioactive bile duct support which can be degraded, used to treat cancer, wherein it is formed by the common bile duct support woven from NiTi alloy lines and the degradable belly film made from radioactive material covering the support. And its production comprises (1), using NiTi alloy lines to weave the bile duct support; (2), plating belly layer on the support, emerging it in crosslinker; (3), freezing and drying; (4), before using, using epoxyethane gas to disinfect it. The invention can treat and restrain the membrane increment and cancer growth, without hurting normal organism. And the epoxyethane, dope and chitose of carrier can be degraded.

The invention provides a 'J' type biliary stent for drainage of high biliary obstruction, which comprises: a bile duct part arranged in a common bile duct and an intestinal part arranged in a duodenum. The intestinal part is integrally connected with the bile duct part. A large 'C' type structure is formed in the intestinal part. By arranging the bile duct part and the intestinal part and settingthe intestinal part as a large 'C' type structure, the intestinal part can form a 'C' type ring at the descending part of duodenum, which effectively avoids the situations of movement of the long frame for drainage of high-level biliary obstruction to the bile duct and slip of the duodenum. As a result, the drainage effect is more stable and reliable, and the practicability of the 'J' type biliary stent for drainage of high biliary obstruction is improved. The manufacture is simple, which facilitates the popularization and application in the market.

The invention belongs to the technical field of medical instruments, and specifically discloses a film-covering-type Y-shaped bile duct stent partially covered with chemotherapeutic drugs. The stent includes a parent stent and a branch stent, and the parent stent is of a bent net-shaped cavity structure; the bent position of the parent stent is provided with a connecting port, and the branch stent is connected in a matching mode with the connecting port of the parent stent; the duct wall, except the connecting port, of the middle of the parent stent and the outer wall of the branch stent are both provided with two layers of chemotherapeutic drug covering films; antitumor bioactive substances are made into a nanoparticle solution and then mixed with a drug carrier to obtain the chemotherapeutic drugs, the chemotherapeutic drugs are sprayed to covering films covered with a glycerinum-gelatin layer, and then the chemotherapeutic drug covering films are obtained; moreover, the chemotherapeutic drugs are clamped in a connection mode between two layers of chemotherapeutic drug covering films. According to the bile duct stent, after the bile duct stent is released and installed in a bile duct, the chemotherapeutic drugs on the chemotherapeutic drug covering films are gradually released in a permeation mode, and the phenomenon of exorbitant instantaneous drug concentration cannot be caused.

The invention provides a suspension-type regurgitation-resistant biliary stent. The stent comprises a biliary duct part for being arranged in the common bile duct and an intestinal part for being arranged in the duodenum, the total length of the biliary stent is smaller than or equal to 25 cm, the length of the biliary duct part is larger than or equal to 10 cm, and the length of the intestinal part is larger than or equal to 13 cm. The biliary stent is placed in the human body and more easily accepted by a patient, complications such as perforation are not easily caused, and when the intestinal part is placed in the duodenum and can reach the horizontal part in the duodenum, the countercurrent condition of content in the duodenum is effectively reduced; in addition, a bending part is located between a first connection segment and a second connection segment, so that a preset angle is formed between the first connection segment and the second connection segment, in this way, the intestinal part can better adapt to deformation of the enteric cavity, the biliary stent is conveniently placed and prevented from being in contact with the intestinal mucosa, and the discomfort of the human body after the stent is placed in the human body is relieved.

The present invention discloses a degradable (P3/4HB-PCL)-PU medical biliary stent material and a preparation method thereof. The material comprises polytetrahydrofuran ether diol (PTMG), hydroxyl terminated polylactic acid (PLA-OH), hexamethylene diisocyanate (HDI), poly-epsilon-caprolactone (PCL), poly 3-hydroxybutyrate-4-hydroxybutyrate (P3/4HB), paclitaxel, lactic acid, non-toxic catalysts, dichloromethane, catalysts and a chain extender. The method comprises the following steps: (1) lactic acid impurity removal; (2) hydroxy-terminated polylactic acid synthesis by direct condensation polymerization; (3) degradable polyurethane medical elastomer synthesis; and (4) degradable (P3/4HB-PCL)-PU medical biliary stent material preparation. The degradable TAXOL-(P3/4HB-PCL)-PU nano-biliary stent is formed by a special soluble core-shaft-assisted coaxial electrospinning technology. The stent has biocompatibility, safety, drug controlled release and benign biliary stricture prevention effect.

The invention discloses an absorbable tubular stent. The absorbable tubular stent is characterized in that the tubular stent is made by blending of polylactic acid and acylated chitosan, and the wall of the tubular stent is provided with or without a porous structure or pattern structure. Due to addition of the acylated chitosan, local acidity generated by the polylactic acid in degradation can be regulated, and oligosaccharides and monosaccharide obtained by degradation of the acylated chitosan can be absorbed and used by organisms, so that high biocompatibility, degradability and absorbability are achieved; the tubular stent has excellent mechanical strength and press resilience. The absorbable tubular stent can be planted in vivo by surgeries to serve as an intravascular stent and is applicable to treatment of embolism or blood vessel lumina narrowing caused by vascular diseases; the absorbable tubular stent can also serve as a biliary stent to be applied to treatment of cholestasis and pancreaticobiliary obstruction caused by pancreatobiliary neoplasms; the absorbable tubular stent can further serve as a urethral stent to be applied to treatment of dysuria resulted from urethral compression caused by prostatic hyperplasia. The absorbable tubular stent can be degraded and absorbed in vivo finally along with lesion repair, in-vivo long-term retention is avoided, and the absorbable tubular stent has a promising market prospect.

The invention, belonging to the field of biomedicine and bio-polymer material, particularly relates to a biodegradable polymer braided stone-dissolving bile duct stent and a preparation method thereof. The stent is prepared by braiding biodegradable polymers to obtain a porous reticulated or spiral tubular braided stent, and then coating a biodegradable drug loaded substance layer containing sodium cholate or/and edetate disodium on the inner surface and outer surface of the braided stent. Clinical outcomes show that the stone-dissolving bile duct stent of the invention has good radial supporting performance, can keep the bile duct open, can be degraded away in a certain time, has good biocompatibility, and lets almost no internal inflammation generate. Simultaneously, sodium cholate or/and edetate disodium slowly released by the polymer layer containing drugs can dissolve the formed stones and can prevent the re-formation of stones.

The invention discloses a recyclable biliary stent. The biliary stent comprises a stent main body, and a lead wire connected with the stent main body, wherein the stent main body is of a spiral shape; an external thread is arranged at the near end of the stent main body, and an internal thread is arranged at the far end of the lead wire; and the lead wire and the stent main body are in threaded connection. The stent main body is of a spiral shape, and is connected with the lead wire, so that the stent main body can be taken out conveniently through the lead wire extending outside a human body.

The invention aims to provide a biliary stent and solves the problems that a biliary stent is non-degradable, poor in matching, prone to moving and poor in biocompatibility in the liver transplantation process. The biliary stent is used for biliary support of an anastomosis part after liver transplantation and comprises a first stent body, a second stent body, a fixing part and a covering film; the first stent body and the second stent body are of a net-shaped hollow structure integrally formed through 3D printing; the outer diameter of the first stent body and the outer diameter of the second stent body are the same as the inner diameter of a donor biliary tract and the inner diameter of a receptor biliary tract respectively; the fixing part is arranged on the outer surface of the joint of the first stent body and the second stent body; and the covering film is arranged on the inner surface of the joint of the first stent body and the second stent body.