81 results about "Biliary tract" patented technology

The invention provides an intraoperative real-time navigation system based on digital twinning, and relates to the technical field of digital twinning, and the system comprises a data collection module which is used for obtaining the three-dimensional form data of a liver and a biliary tract through an intraoperative ultrasonic imaging device, and collecting the elastic modulus distribution parameters of liver parenchyma and a bile duct wall; the construction registration module is used for constructing a real-time digital twin in the liver and gall area based on the three-dimensional form data and the elastic modulus distribution parameters, and carrying out multi-mode non-rigid registration on the digital twin and the liver surface topography and the vascular structure which are subjected to optical coherence tomography in the operation; therefore, a dynamic space mapping relation between the organ structure and the image data is established. According to the method, real-time navigation in the operation is realized through digital twinning, the obstacle avoidance path is updated, and the safety and efficiency in the operation are improved.

The invention relates to a pharmaceutical formulation, e.g. a paediatric formulation, of odevixibat, which comprises a plurality of small particles. The formulation may be used in the treatment of liver diseases such as bile acid-dependent liver diseases, and particularly cholestatic liver diseases such as biliary atresia, progressive familial intrahepatic cholestasis (PFIC), Alagille syndrome (ALGS) and paediatric cholestatic pruritus. The invention also relates to a process for the preparation of the pharmaceutical formulation.

The utility model discloses a multifunctional biliary tract internal and external drainage tube combination device applied to a patient suffering from hilum cholangiocarcinoma. A drainage catheter is transited from a shaping area and an elastic cabin area to an internal drainage area to form a cylindrical cone; side holes are formed in the inner drainage area and the shaping area; a marker point is arranged between the inner drainage area and the missile cabin area, the missile cabin area is distributed between the inner drainage area and the shaping area, a one-way valve is arranged at the contact position between the shaping area and the missile cabin area, a hole channel is formed in the outer wall, extending into the marker point from the missile cabin area along the one-way valve, of the missile cabin area, and the hole channel forms a missile cabin in the missile cabin area. The magazine is used for placing radioactive particles; the hard support is used in cooperation with the drainage catheter, the hard support penetrates into the outer drainage area and then is pulled to the end of the inner drainage area, and the curled part of the shaping area of the hard support is straightened. The utility model can realize internal and external drainage and achieve the purpose of local tumor treatment, and is simple and convenient to operate and easy for medical staff to use.

The invention discloses a biliary tract drainage tube with a particle carrying radiotherapy function. The biliary tract drainage tube comprises a tube body, a stay wire and a stay wire traction fastening device, a bendable pigtail section is arranged at the front end of the tube body, a drainage cavity and a particle cavity are axially arranged in the tube body, and drainage holes communicated with the outside and the drainage cavity are formed in the tube wall of the pigtail section. The stay wire extends to the pigtail section along the drainage cavity and passes through stay wire holes at the head and tail of the pigtail section, and two ends of the stay wire extend out of the rear end of the tube body and converge to the fastening device. The front end of a first connector sleeve of the fastening device is fixedly connected with the rear end of the tube body and communicated with the drainage cavity through a connector inner tube, and a second connector sleeve loosely sleeves the connector inner tube. One end of the pull wire is fixed to the first connector sleeve, the other end of the pull wire movably penetrates out of the second connector sleeve, the pigtail section can be bent by pulling the pull wire, the second connector sleeve is rotated to a set angle, the pull wire is clamped through angle dislocation, and the pigtail section is kept in the bent state. Bending of the pigtail section can be conveniently controlled, the anchoring state can be stably maintained, and the safety and reliability of clinical catheterization can be effectively improved.

The present invention relates to an equipment for magnetic recanalization of benign biliary strictures. The equipment (100) includes a wire-guided magnet pusher tube (102a), atleast one magnet (110), and a magnet retrieval tube (102b). The equipment (100) works in conjunction with a visualization system to guide placement of the magnet (110) at the target site for recanalization of the biliary stricture. The magnet (110), may be deployed at opposing ends of a biliary stricture to create a controlled recanalization channel via magnetic attraction. The deployment process can be performed using endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic biliary drainage (PTBD), or a combination of both. Magnets may be retrieved following recanalization using biopsy forceps or allowed to pass naturally through the digestive tract, avoiding permanent implantation.

The utility model discloses a biliary tract inside and outside drainage device which comprises a drainage catheter, a fixing stay wire and a hard sleeve. The drainage catheter is composed of an inner drainage area, a narrow section covering area, a shaping area and an outer drainage area, and the interior of the drainage catheter is of a hollow structure. One end of the inner drainage area is designed into a cylindrical cone; a clamping table is arranged at one end of the outer drainage area and used for connecting a cap or a drainage bag; side holes penetrating through the inner cavity are formed in the outer walls of the inner drainage area and the shaping area; a marker point is arranged between the rear end of the side hole of the inner drainage area and the narrow section coverage area; the shaping area is curled into a loop in a natural state, and the shaping area can be straightened through the hard sleeve; the narrow section coverage area is distributed between the inner drainage area and the shaping area; the fixing stay wire comprises a fixing piece and a stay wire, and the tail end of the stay wire is connected with the fixing piece. The drainage catheter main body adopted by the utility model is made of a material with good biocompatibility; and internal drainage and external drainage can be realized. Multiple side holes are formed in the middle and the head end of the drainage tube, sufficient drainage is promoted, and infection risks are reduced.

The invention relates to the technical field of medical instruments, and discloses a visual biliary tract rotary cutting biopsy expansion system assembly which comprises a conical sleeve, a visual mechanism is fixedly connected to the interior of the conical sleeve, a holding mechanism is installed on the left side of the visual mechanism, a rotary cutting mechanism is installed at the left end of the holding mechanism, and the visual mechanism comprises a cable. The exterior of the cable is fixedly connected to the interior of the conical sleeve, the top end of the cable is fixedly connected with a golden finger, the left end of the conical sleeve is fixedly connected with a protection assembly, the left end of the protection assembly is fixedly connected with a Luer lock cap, and the interior of the protection assembly is fixedly connected with an insertion pipe; a light source is fixedly connected into the protection assembly. The inside of the biliary tract is uniformly and sufficiently illuminated through the light source, a clear observation view is provided for a doctor, the doctor can accurately judge the illness state, and the situation that the positive rate of hepatopathic bile duct malignant stenosis biopsy is not high is reduced.

The utility model discloses a kind of anti-coming-off pipe device for clinical biliary tract drainage tube, it is related to medical instrument field, specifically for a kind of anti-coming-off pipe device for clinical biliary tract drainage tube, including the fixing plate for fixing biliary tract drainage tube, the both sides of the fixing plate are respectively equipped with adjusting groove, the fixing plate is equipped with the positioning column of adjusting groove insertion, the tail end of the positioning column is equipped with positioning plate, the sliding slot that is equipped with with positioning plate cooperation on fixing plate, the side of the fixing plate is equipped with the buckle plate that is with positioning column cooperation, two described buckle plate between are equipped with the pull rope for fixing biliary tract drainage tube joint, the utility model solves the biliary tract drainage tube of current clinical use, it is easy to influence the normal flow guide of biliary tract drainage tube, but because pipeline is long also easy to sway, it is easy to scratch patient skin, there is another common way is just with a rope to bind the interface of the other end of drainage tube, but the tightness of biliary tract drainage tube cannot be adjusted using this way.

The present application relates to the technical field of biotechnology, more particularly to a biomarker for distinguishing benign biliary disease and cholangiocarcinoma and application thereof. The biomarker for distinguishing benign biliary disease and cholangiocarcinoma provided by the present application comprises 20 kinds of lipids and / or 5 kinds of polypeptides, and the single lipid group or single polypeptide group is used as a biomarker to distinguish benign biliary disease and cholangiocarcinoma, which has high sensitivity. When the lipid group and the polypeptide group are used as multi-group biomarkers, the sensitivity and accuracy of the discrimination can be further improved. In addition, the biomarker combination provided by the present application exists in serum, which is more suitable for non-invasive collection. The reagent or kit prepared based on the biomarker combination is more convenient for popularization and use. The risk prediction model for benign biliary disease and cholangiocarcinoma constructed based on the above biomarker has higher accuracy compared with the existing CA19-9 marker method, whether it is a single omics model or a double omics model.

The application relates to the field of biological medicine, and discloses application of folic acid in prevention, diagnosis and treatment of genetic, infectious or allergic diseases. The application finds that the folic acid can achieve the prevention and treatment effects on the genetic, infectious or allergic diseases by improving inflammation, regulating iron ion metabolism, correcting intestinal flora disorder, reducing liver / intestinal tissue damage, inhibiting expression of inflammatory factors and promoting expression of Nox2. Meanwhile, the application provides application of one or more of the folic acid, S100a8, S100a9, Nox2 and IFN-gamma as a diagnostic or auxiliary diagnostic marker of biliary atresia. Meanwhile, the application provides the folic acid or a derivative thereof, which is prepared into food, a nutritional preparation or a medicine and applied to children or adults, so as to achieve the purposes of preventing and treating biliary atresia, cholangitis, jaundice, infectious diseases, intestinal diseases and diseases caused by abnormal folic acid metabolism.

The utility model discloses a superfine soft choledochoscope guiding aspirator under a laparoscope, which is specially designed for a common bile duct exploration operation through a gallbladder tube superfine choledochoscope and comprises a guiding tube capable of being bent by 150 degrees, the inner diameter of the guiding tube is 3.0 mm, and the superfine choledochoscope can pass through the guiding tube; the guide tube is provided with a small hole and an aspirator interface to attract normal saline flowing out of the choledochoscope to keep the surgical field clear; the head of the guide tube is provided with a soft cap to prevent air leakage. By means of flexible bending design, accurate size control and efficient suction function, accuracy and safety of an operation are remarkably improved. Meanwhile, the choledochoscope guiding device is simple in structure and convenient to operate, and the problems existing in a traditional choledochoscope guiding device are effectively solved. The guide aspirator is suitable for laparoscopic common bile duct exploration operation, has wide clinical application prospects and market value, and provides a new solution for treatment of biliary tract diseases.

The application discloses a medical knowledge enhanced question answering and auxiliary diagnosis and treatment method for biliary surgery, comprising the following steps: recognizing biliary surgery corpus through an entity recognition model to obtain a plurality of biliary surgery entities and extracting the causal relationship between the biliary surgery entities; constructing a biliary surgery knowledge graph based on the biliary surgery entities and the causal relationship, summarizing the information in each biliary community to obtain a plurality of community abstracts; segmenting the community abstracts to obtain a plurality of abstract blocks, calculating the scores of the abstract blocks, screening the abstract blocks according to the scores, obtaining high-relevance abstract blocks, inputting the query text of a user, a structured generation template of a causal chain and the high-relevance abstract blocks into a large language model to obtain a clinical answer text. The application accurately matches clinical causal information through a causal perception mechanism, and outputs answers conforming to a clinical thinking process based on the structured generation of a causal chain, thereby improving the accuracy and interpretability of diagnosis and treatment assistance.

The invention belongs to the technical field of biological medicines, and particularly relates to application of PF-06260933 in preparation of a medicine for treating biliary atresia. The invention provides an application of an HGK inhibitor PF-06260933 in preparation of a medicine for treating biliary atresia. A BA organ and biliary duct ligation (BDL) induced mouse model is constructed, PF-06260933 is adopted to inhibit pro-inflammatory and pro-fibrosis related signal channels of biliary duct epithelial cells, and the improvement effect of PF-06260933 on biliary duct atresia pathological phenotypes is observed. Results show that the PF-06260933 treatment not only can significantly improve inflammatory fibrosis phenotypes of BA organs, but also can significantly improve mouse liver functions, relieve liver inflammation and fibrosis, and effectively reverse pathogenic activation phenotypes of bile duct epithelial cells. Compared with the traditional niberous surgery or non-specific immunosuppression therapy, the method has the advantages of remarkable progress and huge clinical application potential.

The transparent cap of the choledochoscope comprises a cap portion and a connecting portion, the tube wall of the front end, away from the connecting portion, of the cap portion is in an arc shape, and a first annular thread is arranged on the inner wall of the connecting portion. The choledochoscope tip is of a convex structure composed of a head part and a body part, the outer diameter of the head part is smaller than that of the body part, a second annular thread is arranged on the outer wall of the head part, and the second annular thread is connected with the first annular thread in a matched mode to achieve connection between the connecting part and the head part; and the outer diameter of the connecting part is the same as that of the body part. The transparent sleeve can be installed at the front end of a choledochoscope to carry out operations such as gall bladder or bile duct washing, calculus removal, stenosis expansion, gall bladder duct or Oddi sphincter exploration and the like; the transparent cap is firmly mounted and cannot fall off; the outer diameter of the connecting part of the transparent cap is consistent with the outer diameter of the choledochoscope body part, the tube wall at the front end of the cap part of the transparent cap is arc-shaped, and tissues such as fistulous tracts, gallbladders and bile duct mucosa are not damaged in the choledochoscope examination and treatment process.

This invention discloses a method for fabricating a memristor based on a bile functional layer, belonging to the field of bioelectronic device fabrication and in vitro diagnostics of biliary tract diseases. The method sequentially completes FTO substrate pretreatment, bile functional layer preparation, Ag-on-electrode deposition, and memristor detection array fabrication. First, the FTO substrate is physically cleaned and plasma-activated. Then, a 240-260 nm bile functional layer is prepared. Subsequently, an Ag-on-electrode is deposited, and a 5-15 nm Ag atom embedding transition region is constructed. Finally, a 2×2 array is arranged and passivated for isolation. The process parameters of each step are synergistically matched to optimize the interface between the substrate, functional layer, and electrode, fully preserving bile pathological information. The resulting Ag / Bile / FTO structure memristor exhibits high electrical stability and shows significant differences in electrical response to bile samples from normal, gallstone, and gallbladder cancer patients. It enables accurate and rapid in vitro identification of biliary tract diseases, and the process is simple, low-cost, and suitable for clinical application and large-scale production.

The present invention relates to 1H-pyrrolo[3,2-c]pyridine and 1H-pyrrolo[2,3-c]pyridine derivatives of formula (I) or a salt thereof. The present compounds are inhibitors of TLR9 and useful in treating preventing, or slowing fibrotic diseases, such as e.g. liver fibrosis, renal fibrosis, biliary fibrosis or pancreatic fibrosis, nonalcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), chronic kidney disease, diabetic kidney disease, primary sclerosing cholangitis (PSC) or primary biliary cirrhosis (PBC), or idiopathic pulmonary fibrosis (IPF).

The invention discloses a preparation method and application of exosome-loaded Cas13d-RNP, and belongs to the technical field of biliary atresia research. The method comprises the following steps: extracting exosomes: culturing human bile duct cells H69 in a DMEM / F12 culture medium until the cell density reaches 90%, collecting supernatant of the culture medium, and extracting the exosomes by an ultracentrifugation method; cas13d-RNP loading: the Cas13d protein and crRNA are mixed for 15 minutes at the room temperature, Cas13d-RNP is obtained, the exosome and the Cas13d-RNP are mixed, and the Cas13d-RNP is loaded into the exosome in a circulating freezing and thawing mode. According to the invention, Cas13d-RNP is accurately delivered through the exosome vector, specific targeting is carried out on bile duct cell CTGF mRNA, and expression of fibrosis-related factors in bile duct cells is significantly reduced. Compared with traditional medicine treatment, bile duct reaction and fibrosis processes can be more effectively inhibited. As a natural vector, the exosome has the advantages of low immunogenicity and high delivery efficiency, and immunoreactions possibly caused by a traditional virus vector are reduced.

Medical devices and method for making and using the same are disclosed. An example medical device may include implantable medical device for use along the biliary and / or pancreatic tract. The implantable medical device may include a tubular member having a first end configured to be disposed within the duodenum of a patient and a second end configured to be disposed adjacent to a pancreatic duct and / or bile duct. The tubular member may have a body including one or more wire filaments that are woven together. The tubular member may also have an outer surface with a longitudinal channel formed therein.

The application provides a novel DNA methylation marker TAGMe-5 for tumor identification and use thereof. The tumor marker TAGMe-5 of the application shows significant DNA methylation difference between cancer adjacent tissue and cancer tissue, and the difference has significant statistical significance, and the difference is shown in numerous tumors such as solid tumors and non-solid tumors. The solid tumors include lung cancer, liver cancer, prostate cancer, cervical cancer, endometrial cancer, urothelial carcinoma, biliary tract tumor, etc. The non-solid tumors include hematological tumors, lymphoma, etc. Therefore, the tumor marker of the application can be used for clinical screening of pan-cancer, molecular diagnosis, prognosis and efficacy evaluation.

The present application relates to the detection and diagnosis of malignant biliary strictures, in order to solve the problem that the prior art cannot accurately locate and sample in real time during DSOC operation, the present application provides a real-time detection and diagnosis system and method based on malignant biliary strictures during DSOC operation, including data acquisition and quality control module for collecting video data during DSOC operation, output quality control frame sequence; The first stage morphological feature detection module is used for detecting and positioning a plurality of malignant related morphological features, and outputting the boundary box coordinates and the confidence; The second stage benign and malignant diagnosis classification module is used for carrying out benign and malignant two classification on the quality control frame sequence, and outputs the malignant probability and the two classification results; The explainability module is used for generating a heat map and spatial consistency analysis, and obtaining a visual video frame sequence; The deployment demonstration module is used for real-time receiving, displaying and storing the intraoperative DSOC video data, the boundary box coordinates and the confidence, the video level diagnosis result and the visual video frame sequence.

The drainage device comprises a drainage bag and a drainage tube, a sealing valve is fixedly installed at the right end of the drainage tube, the drainage tube is in threaded connection with the drainage bag through the sealing valve, and a connecting tube is fixedly installed on the surface of the right end of the drainage tube; a butt joint assembly is fixedly installed at the end, away from the drainage tube, of the connecting tube, a piston assembly is in threaded connection with the end, away from the connecting tube, of the butt joint assembly, and an indicating assembly is fixedly installed at the right end of the piston assembly. When the pressure in the biliary tract changes, the piston plate is driven to slide in the piston cylinder, the rack plate is driven to move in the left-right direction in cooperation with the connection effect of the push rod, then the rotating shaft and the pointer are driven to rotate through the meshing effect of the rack plate and the gear, and the number indicated by the pointer on the surface of the circular shell reflects the pressure in the biliary tract. Therefore, the purpose of conveniently and quantitatively indicating the pressure change in the biliary tract is achieved.

The invention belongs to the technical field of biological medicine, and particularly relates to a biliary atresia differential diagnosis and prognosis marker and application thereof. The invention provides the application of the KRT17 expression level as a biliary atresia differential diagnosis and prognostic marker for the first time. KRT17 as a single marker has a relatively high diagnostic value (AUC = 0.880) for BA, the efficiency of KRT17 is superior to all conventional clinical liver function indexes, and when KRT17 is combined with alanine aminotransferase for use, the diagnostic accuracy can be further improved to AUC = 0.904, the KRT17 and CX3CL1 are optimally combined, and the AUC value is as high as 0.938. According to the technology, KRT17 is used as a novel biliary atresia differential diagnosis marker, the defects of an existing differential diagnosis system can be made up to a certain degree, the KRT17 is specifically and highly expressed in biliary atresia liver bile duct epithelial cells, normal control and disease control are not expressed, and therefore more accurate differential diagnosis can be provided clinically.

Systems and methods for treating, for example, strictures along a biliary tract and / or pancreatic duct are disclosed. An example system can include a handle (14) having a base, a first carriage (26) translatable relative to the base, and a second carriage (24) translatable relative to the base. A sheath (16) can be coupled to the first carriage. The system can also include a catheter shaft (12) having a proximal region and a steerable distal region. The proximal region can be coupled to the second carriage. A needle can be releasably coupled to the handle. The needle can be configured to pass through tissue to a location along a biliary tract and / or pancreatic duct. The system can also include a steering member (44) having a first end coupled to the steerable distal region of the catheter shaft and a second end disposed adjacent the handle.

The invention discloses a tumor clinical interventional therapy percutaneous liver puncture biliary drainage auxiliary device, comprising: a clamping protection mechanism comprising a clamping frame assembly and a gooseneck assembly which is arranged on the clamping frame assembly and can be adjusted in position along the vertical direction; the complication monitoring assembly comprises a monitoring host installed on the clamping frame assembly, and a temperature sensor and an ultrasonic flow sensor which are electrically connected with the monitoring host; the temperature sensor is used for monitoring the body temperature of a patient in real time, and the ultrasonic flow sensor is connected with the drainage tube and used for achieving non-invasive monitoring of the bile flow velocity; the binding belt assembly is used for being fixed to the waist and abdomen of a patient in a surrounding mode, and the binding belt assembly is provided with a first through hole used for a drainage tube to pass through and a second through hole used for a temperature probe of a temperature sensor to pass through; the problems that an existing percutaneous liver puncture biliary tract drainage auxiliary device is poor in drainage tube protection effect and insufficient in complication risk monitoring capacity are solved.

The application discloses a biomarker for prognosis evaluation of extrahepatic cholangiocarcinoma, a prognosis risk evaluation system and application, and belongs to the technical field of bioinformatics. The application adopts the combination of miR-34c-5p, miR-100-5p, miR-193b-5p, miR-122-5p, miR-5588-5p and miR-122-3p as a biomarker, can effectively improve the accuracy of differential diagnosis of extrahepatic cholangiocarcinoma, can distinguish extrahepatic cholangiocarcinoma patients from healthy people and benign biliary disease patients with high precision, and overcomes the limitation that traditional tumor markers such as CA19-9 are prone to false positive results in benign biliary diseases. Meanwhile, the expression level change of the biomarker combination can dynamically reflect the postoperative tumor load change, and is helpful for accurately evaluating the surgical effect.

The application belongs to the field of biological medicine, and particularly relates to a group of gene mutations and application thereof in diagnosis of pancreaticobiliary duct cancer. Specifically, the application provides a group of gene mutations for detecting pancreaticobiliary duct cancer, wherein the gene mutations include one or more of AKT1, KRAS, APC, NRAS, ARID1A, PIK3CA, AXIN1, PPP2R1A, BAP1, PTEN, BRAF, SMAD4, CDKN2A, TERT, TP53, EGFR, FBXW7, FGFR2, HRAS, IDH1 and IDH2.

Disclosed is a foreign body removal device, relating to the field of medical instruments. The foreign body removal device comprises a foreign body removal part (100), an adjustment part (200), and an operation part (500). One end of the foreign body removal part (100) is weaved and gathered to form a gathered part (120), the operation part (500) is fixedly connected to the tail end of the gathered part (120), the adjustment part (200) is annularly arranged on the outer side of the gathered part (120), and one end of the adjustment part (200) is fixedly connected to the operation part (500). The overall diameter of the foreign body removal device is extremely small, which is reduced by 50% or more compared with the overall diameter of a traditional stone removal basket product, and the foreign body removal device can be directly fed into a smaller cavity. The positions such as the biliary tract and the intestine can be easily reached, and meanwhile, the effective rotation of the foreign body removal part (100) can be ensured under various bends, thereby greatly expanding the application range of stone removal and foreign body treatment.

The utility model relates to a biliary tract drainage device which comprises a T tube, a drainage bag and a drainage tube, one end of the drainage tube is communicated with the T tube through a connector, and the other end of the drainage tube is communicated with the drainage bag. The joint comprises a female joint and a male joint, the female joint sleeves the male joint and is in threaded connection with the male joint, the male joint is connected with the drainage tube, the female joint is connected with the T tube, and an elastic self-sealing blocking piece is arranged between the female joint and the male joint. According to the utility model, the blocking piece which can be elastically and automatically sealed is arranged in the connector, when the drainage bag needs to be replaced, the female connector and the male connector are separated, the female connector connected with the T tube can be automatically sealed, bile is not easy to leak, and the wound infection probability is reduced.

The utility model provides a laparoscope bile duct calculus taking-out device, and relates to the technical field of medical instruments, the laparoscope bile duct calculus taking-out device comprises an operating handle, one end of the operating handle is connected with a duodenoscope, a mechanism used for fixing the duodenoscope is arranged in the operating handle, the surface of the duodenoscope is fixedly sleeved with a shifting piece, and the shifting piece is connected with the operating handle. And a biliary tract sub-mirror is arranged in the duodenoscope. According to the device, the operation steps are very simple and convenient, the phenomenon that the duodenoscope possibly falls off after being used for a long time is avoided, the connecting efficiency of the duodenoscope and the operation handle is indirectly improved, and the practicability is greatly improved through the design.

The invention belongs to the technical field of biological medicines, and particularly relates to application of parinumod in preparation of a medicine for treating biliary atresia. The invention discovers the treatment application of the S100A8 / A9 inhibitor in biliary atresia for the first time. The method comprises the following steps: inducing the formation of BA by intraperitoneal injection of RRV within 24 hours after a BALB / c newborn mouse is born, and after the RRV is injected from the intraperitoneal cavity, from the second day, injecting an S100A8 / A9 inhibitor Paquinimod (dosage: 50 mg / kg) into the intraperitoneal cavity of the mouse once every other day until the twelfth day. It can be observed that the survival time of the BA mouse treated by Paquinimod is prolonged, the jaundice symptom is relieved, the liver function index is obviously improved, and the infiltration number of inflammatory cells around the hepatic bile duct is obviously reduced. The invention provides a new potential target and a treatment strategy for treatment of BA.