301 results about "Biliary tract" patented technology

The invention belongs to the technical field of biological medicine, and particularly discloses an antibody targeting ADAM17 protein and application of the antibody. The invention provides the ADAM17 specific target spot aiming at the malignant tumor of the biliary tract, the ADAM17 is highly expressed in the tumor of the biliary tract and is relatively low in expression in normal tissues, and by intervening the target spot, tumor cells can be killed, and non-specific attack to normal cells can be avoided as much as possible, so that the effectiveness and the safety of treating a patient with the malignant tumor of the biliary tract are improved. The invention also provides an antibody targeting ADAM17 protein and a preparation and screening method thereof, and the antibody can specifically recognize an antigen binding domain of ADAM17, has strong affinity with an ADAM17 antigen, and can be used for treating ADAM17 positive malignant tumors.

The utility model relates to a biliary tract woven stent, which comprises a woven stent formed by weaving one or a plurality of woven filaments, the woven filaments are wound along the axis in a positive and negative spiral line mode and interwoven with one another, and the mutually staggered woven filaments form a lap joint buckle structure capable of freely sliding or a hooking buckle structure limited in sliding at nodes. According to the technical scheme, the structure is reasonable, the stent can be degraded automatically while the radial supporting force of the stent is improved, and the stent taking-out operation is omitted.

Medical devices and methods are disclosed. An example medical device for accessing a body cavity along a biliary and / or pancreatic tract may include an elongate member having a distal end and a proximal end. The medical device may have a flexible distal tip. The flexible tip may be steered by applying tension to one or more steering wires extending between the distal tip and a handle located at a proximal end of the medical device. The medical device may be a sphincter.

The invention discloses an application of the number of neutrophils in predicting the curative effect of oncolytic viruses in treating tumors. In the application, the neutrophile granulocyte number level in the blood of a tumor patient is closely associated with the tumor treatment effect, and the applicable tumor syndromes are common, including melanoma, colorectal cancer, esophageal cancer, head and neck tumors, gastric cancer, biliary tract system tumors, sarcoma and other tumors. In the application, the critical value of the number of neutrophils for predicting the tumor treatment effect is 2 * 10 < 9 >-5.5 * 10 < 9 > / L, and the most preferable critical value is 4.0 * 10 < 9 > / L; the curative effect of OH2 single-drug treatment on tumor patients with the neutrophil number level below a critical value is better than that of tumor patients with the neutrophil number level above the critical value.

The invention provides an intraoperative real-time navigation system based on digital twinning, and relates to the technical field of digital twinning, and the system comprises a data collection module which is used for obtaining the three-dimensional form data of a liver and a biliary tract through an intraoperative ultrasonic imaging device, and collecting the elastic modulus distribution parameters of liver parenchyma and a bile duct wall; the construction registration module is used for constructing a real-time digital twin in the liver and gall area based on the three-dimensional form data and the elastic modulus distribution parameters, and carrying out multi-mode non-rigid registration on the digital twin and the liver surface topography and the vascular structure which are subjected to optical coherence tomography in the operation; therefore, a dynamic space mapping relation between the organ structure and the image data is established. According to the method, real-time navigation in the operation is realized through digital twinning, the obstacle avoidance path is updated, and the safety and efficiency in the operation are improved.

The invention belongs to the technical field of medical instruments, and particularly relates to test equipment for diagnosis and analysis of biliary tract disease images, which comprises a bottom plate, a frame body fixedly mounted at the top of the bottom plate, a support frame fixedly mounted in the frame body, a lens cone fixedly mounted on the support frame, a converter mounted on the lens cone, and an objective table fixedly mounted on the support frame, an adjusting assembly is arranged in the strip-shaped groove and connected with a supporting plate, a strip-shaped plate is fixedly installed on the supporting plate, and a scraping plate is fixedly installed on the strip-shaped plate. According to the testing equipment for biliary tract disease image diagnosis and analysis, the surface of the objective table can be conveniently cleaned through the arranged scraper, when the objective table is cleaned, a double-output-shaft motor works to drive a threaded lead screw to rotate, when the threaded lead screw rotates, a sliding block moves, synchronous movement is driven through a supporting plate, the scraper makes contact with the top of the objective table, and thus the objective table is cleaned. And when the scraping plate moves, impurities above the objective table can be removed, so that the objective table is cleaned.

The utility model belongs to the technical field of medical instruments, and particularly relates to a biliary tract drainage catheter assembly which comprises a catheter body, a mounting block is arranged outside the catheter body, a sleeve hole is formed in the mounting block, clamping blocks are arranged on the two sides of the interior of the sleeve hole, side blocks are fixedly connected to the two sides of the exterior of the mounting block, and winding rollers are rotationally connected to the interiors of the side blocks. The utility model provides a biliary tract drainage catheter assembly which solves the problems that in the prior art, after a drainage catheter is left in the body of a patient, the drainage catheter is generally pasted on the skin of the patient through a medical adhesive tape and fixed outside the body of the patient, but part of the patient is allergic to the adhesive tape, the catheter cannot be fixed through the adhesive tape, and the drainage catheter cannot be fixed through the medical adhesive tape. Sometimes, medical staff bind a catheter to the outside of a patient through a binding band, but the mode of binding through the binding band easily causes bending of the catheter, the drainage effect is affected, and the comfort is also reduced due to friction generated between the catheter and the skin of the patient after long-time binding.

The invention provides a drainage device capable of measuring biliary tract pressure, and relates to the technical field of biliary tract drainage equipment. A drainage device capable of measuring biliary tract pressure comprises a drainage hose, a pressure measuring mechanism is arranged on the drainage hose and comprises a pressure measuring tube, and one end of the pressure measuring tube is connected with the drainage hose; one end of the piezometric tube is provided with plugging liquid, and the other end of the piezometric tube is provided with a sliding plug which is connected with a control rod; calibration liquid is arranged in the pressure measuring pipe. Compared with the prior art, the device is simple in structure, convenient to use and capable of effectively observing pressure and adjusting the pressure.

The invention discloses a liver, gall and pancreas patient symptom evaluation system based on multi-dimensional data, and relates to the technical field of liver, gall and pancreas symptom evaluation. The visual management platform is in communication connection with a data acquisition module, an abnormal symptom classification module, a symptom risk analysis module, a symptom risk classification module and a report generation module, and all the modules are in electric signal connection; the data acquisition module is used for collecting and preprocessing multi-dimensional index data of a liver function index, a biliary system index and a pancreas index of a patient. By integrating the multi-dimensional data of the liver function index, the biliary system index and the pancreas index, the health condition of the liver, gall and pancreas patient can be more comprehensively reflected, compared with a traditional single-dimensional evaluation method, the abnormal symptoms of the patient can be more accurately recognized, the possibility of misdiagnosis and missed diagnosis is reduced, and the diagnosis accuracy is improved. And personalized symptom risk assessment can be carried out according to specific data of each patient, so that the medical decision is more accurate.

A surgical instrument for percutaneous transhepatic choledochoscope diagnosis and treatment is used for establishing a first-stage surgical channel of the percutaneous transhepatic choledochoscope and sinus tract forming of staging surgery, and the surgical instrument system is composed of a surgical working channel sheathing canal and a sinus tract forming drainage tube. The operation working channel sheathing canal is provided with a straight pipe, a bent pipe, an adjustable bending design and an adjustable bending device so as to adapt to all levels of bile ducts to walk, is provided with an anti-squashed pipe body or a variable-diameter material or a variable-diameter device pipe body, a controllable negative pressure connector, an endoscope insertion channel, a sealing cap and an instrument channel, and is provided with an expansion pipe, so that the sheathing canal can be conveniently and smoothly placed into the biliary tract; the sinus tract forming drainage tube body is of a reducing structure, adapts to the volume of a bile duct cavity, is provided with a pigtail-shaped anti-falling device, a fixing line and other anti-falling devices, reduces falling of the drainage tube, is provided with a side hole, can achieve the bile drainage function, is provided with a fixed Luer taper and a movable Luer taper, facilitates imbedding of the sinus tract forming drainage tube in different operation scenes, and is convenient to use. The device is used for improvement and smooth implementation of percutaneous transhepatic choledochoscope surgery.

The invention belongs to the technical field of biological medicines, and particularly relates to application of ganoderic acid A in preparation of a medicine for preventing and / or treating biliary atresia. The new application of ganoderic acid A in preparation of drugs for preventing and / or treating biliary atresia is found for the first time. The method comprises the following steps: within 24 hours after a BALB / c newborn mouse is born, inducing the formation of BA by intraperitoneal injection of RRV, and from the second day after intraperitoneal injection of RRV, carrying out intraperitoneal injection of Ganoderic Acid A on the mouse every day until the twelfth day, it can be observed that the survival time of BA mice treated by the Ganoderma Acid A is prolonged, the weight loss is obviously improved, the jaundice symptom is relieved, the liver function index is obviously improved, the infiltration number of inflammatory cells around the intrahepatic bile duct is obviously reduced, and the liver bile duct injury is relieved. The invention provides a new potential target and a treatment strategy for treatment of BA, and has potential clinical treatment significance.

The invention relates to a pharmaceutical formulation, e.g. a paediatric formulation, of odevixibat, which comprises a plurality of small particles. The formulation may be used in the treatment of liver diseases such as bile acid-dependent liver diseases, and particularly cholestatic liver diseases such as biliary atresia, progressive familial intrahepatic cholestasis (PFIC), Alagille syndrome (ALGS) and paediatric cholestatic pruritus. The invention also relates to a process for the preparation of the pharmaceutical formulation.

The utility model relates to the technical field of medical instruments, in particular to a multifunctional biliary tract drainage tube with double-cavity sacculus auxiliary expansion through a PTCD (percutaneous transluminal compact disc) way, which comprises a drainage tube, a sacculus expansion tube group, a water injection tube and a sacculus, the fixing shell set comprises a drainage tube fixing shell and a water injection tube fixing shell arranged on the periphery of the drainage tube fixing shell, the drainage tube fixing shell is connected with the drainage tube, and the water injection tube fixing shell is connected with the water injection tube; the internal and external intercommunication window is communicated with a first area on the drainage tube and a second area, corresponding to each other, on the water injection tube, so that bile outside the water injection tube flows into the drainage tube through the internal and external intercommunication window. The multifunctional biliary tract drainage tube for assisting expansion through the PTCD way double-cavity balloon integrates biliary tract expansion and bile drainage, operation is reduced, and operation cost can be greatly reduced.

The invention discloses an application of a pyroptosis inhibitor in preparation of a product for treating biliary atresia, the pyroptosis inhibitor 2-bromohexadecanoic acid has a certain treatment effect on biliary atresia mice, can significantly prolong the survival time of the mice, improve jaundice, improve the liver function of the mice, reduce the infiltration quantity of inflammatory cells around intrahepatic bile ducts, and can be used for treating the biliary atresia. A new potential target and a treatment strategy are provided for treatment of biliary atresia.

The invention discloses a magnetic control steerable guide wire and an ERCP biliary tract probing and calculus removing operation method thereof.The magnetic control steerable guide wire comprises a magnetic control guide wire body and an external electromagnetic coil, the magnetic control guide wire body comprises a head end magnetic control module, a flexible transition section, a guide wire body section and a near-end control handle, the tail end of the head end magnetic control module is connected with the flexible transition section, and the tail end of the guide wire body section is connected with the external electromagnetic coil; the tail end of the flexible transition section is connected with a guide wire main body section, the tail end of the guide wire main body section is connected with a near-end control handle, and the external electromagnetic coil comprises an annular coil and an insulating layer.By means of guide wire head end magnetic force control and external magnetic field guiding, the problem that guide wire intubation is difficult due to the fact that a gallbladder duct and a total hepatic duct form an angle is solved; and through magnetic control of the head end of the guide wire and guidance of an external magnetic field, the problem that the guide wire is difficult to intubate due to angulation of the gallbladder duct and the total hepatic duct is solved, and the success rate and the safety of taking out the biliary calculus are improved.

The utility model discloses an intestinal puncture drainage device which comprises a negative pressure drainage bottle, the negative pressure drainage bottle is connected with a hose, the end, away from the negative pressure drainage bottle, of the hose is detachably connected with a hard needle core, the hard needle core is sleeved with a soft sleeve and a hard sleeve, one end of the soft sleeve is fixed to the head of the hard needle core, and the other end of the soft sleeve is fixed to the hard sleeve. The soft cannula is of a fusiform structure, a grab handle is fixedly installed at the end, away from the soft cannula, of the hard needle core, the fusiform soft cannula and the hard cannula which are arranged on the hard needle core in a sleeving mode are arranged, after the soft cannula is inserted into the intestinal tract, the hard cannula can be pushed to enable the soft cannula to be extruded and arched, the outer diameter of the hard cannula is larger than that of the hard needle core, the hard needle core is slowly pulled outwards, and therefore the soft cannula can be inserted into the intestinal tract. When the biliary tract is punctured, the bulged soft sleeve abuts against the inner wall of the intestinal tract, so that intestinal juice is prevented from leaking out after the intestinal tract is punctured, a silk thread does not need to be arranged in advance to ligate the tail end of the biliary tract and the catheter during injection and drainage, and the phenomenon that liquid medicine leaks out is avoided.

The invention discloses application of neutrophile granulocyte number level in prediction of tumor treatment effect. Through verification of the embodiment of the invention, the number level of neutrophils in blood of a tumor patient before treatment is closely associated with the curative effect of tumor treatment, especially OH2 treatment, and the applicable tumor adaptation diseases are common; comprising at least one of melanoma, esophageal cancer, right breast invasive ductal cancer, intestinal cancer, head and neck tumor, gastric cancer, ovarian cancer, biliary system tumor, left foot back squamous cell carcinoma, sarcoma and osteosarcoma, lung cancer, thymosquamous cell carcinoma and brain glioma. In the application disclosed by the invention, the threshold value of the number of neutrophils for predicting the tumor treatment effect is 3.5 * 10 < 9 > / L; the treatment is predicted to be effective when the number of sexual granulocytes in a tumor patient is below 3.5 * 109 / L before the tumor patient is treated, and the treatment is predicted to be ineffective or invalid when the number of sexual granulocytes in the tumor patient is higher than 3.5 * 109 / L. The application method is simple, low in cost and good in stability, and can become a potential prediction means for clinicians.

The invention discloses a drainage catheter for a biliary tract and a biliary tract negative pressure drainage system. The biliary tract negative pressure drainage system comprises a negative pressure instrument, a liquid storage device, a drainage catheter and a catheter fixator. Wherein the negative pressure instrument is used for providing negative pressure and carrying out pressure detection. The liquid storage device is connected with the negative pressure instrument, so that negative pressure is formed in the liquid storage device through the negative pressure instrument. The drainage catheter comprises a connector, a catheter body and a pull wire. The connector is used for being connected with a liquid storage device and used for conveying liquid into the liquid storage device. The tube body is connected with the connector and used for drainage of liquid. The stay wire is arranged in the tube body in a penetrating mode so as to pull the far end of the tube body to form a pigtail-shaped circle. The catheter fixator is connected with the catheter body of the drainage catheter and used for fixing the catheter body to the skin surface near the biliary tract. When the far end of the catheter body forms a pigtail-shaped circle, the center line of the drainage catheter and the center line of the drainage section are located in the same plane, so that the drainage tip does not protrude, and the safety of biliary tract drainage is effectively improved.

The utility model discloses a flexible bendable catheter for a fiber choledochoscope, which relates to the technical field of catheters, and comprises a first catheter body and a second catheter body, the opposite ends of the first catheter body and the second catheter body are provided with gooseneck bending tubes of an integrated structure, the lower end of the second catheter body is fixedly provided with a hose, and the hose is fixedly provided with a flexible pipe. The first pipe body, the second pipe body and the hose are each composed of an inner layer, a steel wire braid layer and an outer layer which are arranged from inside to outside, a mounting pipe is fixedly mounted on the left side of the outer surface of the first pipe body, and an external thread part is arranged on the left side of the outer surface of the mounting pipe. The gooseneck bending tube is arranged, so that the catheter is easy to bend, the inner layer, the steel wire braid layer and the outer layer are arranged, so that the catheter has the advantages of being flexible and bendable, the application range is wide, the steel wire braid layer improves fracture resistance, distortion resistance, compliance and elastic performance of the catheter, pushing force conduction is facilitated, torsion conduction can be improved, and the service life of the catheter is prolonged. The catheter can be bent into any shape, so that the catheter can pass through the biliary tract, and the catheter is flexible to control.

The utility model relates to a biliary tract drainage device which comprises a drainage tube, a catheter seat and a locking connector. The drainage tube comprises a tube body section and a pigtail section extending at the far end of the tube body section, the tube body section is provided with a central cavity and a plurality of peripheral cavities which extend in the length direction, and the pigtail section is provided with an inner cavity communicated with the central cavity. The near end of the catheter body section is fixedly connected with the catheter base, and the catheter base is detachably connected with the locking connector. A plurality of first drainage holes are formed in the side wall of the pigtail section, the first drainage holes are communicated with an inner cavity of the pigtail section, and when the pigtail section forms a pigtail ring, the first drainage holes are located in the inner side of the pigtail ring. A second drainage hole is formed in the side wall of the far side of the catheter body section and communicated with the central cavity. The locking connector is provided with an inner cavity extending in the length direction, and when the locking connector and the catheter base are in the assembled connection state, the inner cavity of the locking connector is at least communicated with the center cavity. According to the biliary tract drainage device, the size of the catheter connector can be reduced.

The invention relates to the technical field of medical equipment and biomarker detection, and provides an optical fiber biosensing probe for detecting a biomarker in a biliary tract, the optical fiber biosensing probe comprises a computer, a spectrometer and a light source, the computer is electrically connected with the spectrometer, the spectrometer is electrically connected with the light source, the output end of the light source is connected with a probe, and the surface of the probe is of a spiral structure; the probe extends into a biliary tract system, the light source emits light with specific wavelength and intensity, so that the light can reach the probe along the incoming optical fiber, and a biomarker in the biliary tract is specifically combined with the surface of the probe, so that an optical signal is changed and output through the outgoing optical fiber; the spectrograph can be used for carrying out detailed spectral analysis on an optical signal output from the outgoing optical fiber, and the spectral analysis comprises the characteristics of wavelength, intensity, absorption peak and the like, so that in-vivo, rapid, accurate and stable detection on bile protein in the biliary tract is realized; during bile detection, collection, storage and in-vitro detection are not needed, the pollution deterioration possibility is small, and the in-vivo detection result is more real.

The present invention belongs to the technical field of medical devices, and specifically relates to a bile duct stone removal instrument in ERCP surgery, which is mainly used for removing gallstones in ERCP surgery; it mainly comprises: a main branch, having a first proximal end and a first distal end opposite to each other; a push tube, having a second proximal end and a second distal end opposite to each other, wherein the push tube is sleeved on the outer side of the main branch; a stone removal part, which is arranged around the first proximal end of the main branch and connected to the second proximal end, wherein the stone removal part is configured such that when the second proximal end moves toward the first proximal end, the stone removal part is partially away from the outer wall of the main branch to present an expanded state, and when the second proximal end moves toward the direction away from the first proximal end, the stone removal part is partially close to the outer wall of the main branch to present a contracted state; it mainly solves the problem that the existing stone removal basket or stone removal balloon cannot grasp the stones well, resulting in the need for repeated operations, thereby prolonging the operation time and increasing the pain of the patient.

The utility model relates to a guide sheath for assisting a choledochoscope to enter and exit from a biliary tract, which comprises a guide sheath body, a guide sleeve and a guide sleeve, an inlet is arranged on one side of the guide sheath body, a channel is arranged in the guide sheath body, and a transition cambered surface is arranged between the channel and the inlet; a guide sheath tube; the connector component comprises a butt joint part and a rotating part, the guiding sheath tube is arranged on the side, away from the rotating part, of the butt joint part, a plurality of elastic pieces capable of elastically and constantly abutting against the transition cambered surface are arranged on the side, away from the butt joint part, of the rotating part, and a groove is formed in the outer side of the rotating part; and the limiting part is detachably connected with the guide sheath body and is used for blocking and limiting the butt joint part through the groove. When the guide sheath used for assisting the choledochoscope in entering and exiting from the biliary tract is used in cooperation with the choledochoscope, the angle adjustment requirement of the choledochoscope can be met, the guide sheath tube can be kept still, the situation that the guide sheath tube hurts the interior of the human body is avoided, and the guide sheath used for assisting the choledochoscope in entering and exiting from the biliary tract can be applied to a gall-stone operation.

The utility model discloses a multifunctional biliary tract internal and external drainage tube combination device applied to a patient suffering from hilum cholangiocarcinoma. A drainage catheter is transited from a shaping area and an elastic cabin area to an internal drainage area to form a cylindrical cone; side holes are formed in the inner drainage area and the shaping area; a marker point is arranged between the inner drainage area and the missile cabin area, the missile cabin area is distributed between the inner drainage area and the shaping area, a one-way valve is arranged at the contact position between the shaping area and the missile cabin area, a hole channel is formed in the outer wall, extending into the marker point from the missile cabin area along the one-way valve, of the missile cabin area, and the hole channel forms a missile cabin in the missile cabin area. The magazine is used for placing radioactive particles; the hard support is used in cooperation with the drainage catheter, the hard support penetrates into the outer drainage area and then is pulled to the end of the inner drainage area, and the curled part of the shaping area of the hard support is straightened. The utility model can realize internal and external drainage and achieve the purpose of local tumor treatment, and is simple and convenient to operate and easy for medical staff to use.

The invention discloses a biliary tract drainage tube with a particle carrying radiotherapy function. The biliary tract drainage tube comprises a tube body, a stay wire and a stay wire traction fastening device, a bendable pigtail section is arranged at the front end of the tube body, a drainage cavity and a particle cavity are axially arranged in the tube body, and drainage holes communicated with the outside and the drainage cavity are formed in the tube wall of the pigtail section. The stay wire extends to the pigtail section along the drainage cavity and passes through stay wire holes at the head and tail of the pigtail section, and two ends of the stay wire extend out of the rear end of the tube body and converge to the fastening device. The front end of a first connector sleeve of the fastening device is fixedly connected with the rear end of the tube body and communicated with the drainage cavity through a connector inner tube, and a second connector sleeve loosely sleeves the connector inner tube. One end of the pull wire is fixed to the first connector sleeve, the other end of the pull wire movably penetrates out of the second connector sleeve, the pigtail section can be bent by pulling the pull wire, the second connector sleeve is rotated to a set angle, the pull wire is clamped through angle dislocation, and the pigtail section is kept in the bent state. Bending of the pigtail section can be conveniently controlled, the anchoring state can be stably maintained, and the safety and reliability of clinical catheterization can be effectively improved.

Described herein is a method of treating biliary tract cancer (BTC) comprising administering to a subject a bispecific antigen-binding construct targeting HER2 or a bispecific antigen-binding construct (ADC) targeting HER2 linked to an auristatin analog.

The present invention relates to a method for treating cancer in a human subject. The method comprises: (a) orally administering enuracil to the subject at a dose of 30-60 mg / day; (b) orally administering capecitabine to the subject for consecutive 2-14 days at a dose of about 140-700 mg / day or a dose that provides a 5-FU exposure (AUC) of about 1500 h * ng / mL or greater at least 10 hours after step (a); and (c) repeating the steps (a) and (b) 3-14 days after the step (b). The pharmaceutical composition is suitable for treating colorectal cancer, gastrointestinal tumor, breast cancer, pancreatic cancer, head and neck cancer, lung cancer or advanced biliary tract cancer.

The present invention relates to an equipment for magnetic recanalization of benign biliary strictures. The equipment (100) includes a wire-guided magnet pusher tube (102a), atleast one magnet (110), and a magnet retrieval tube (102b). The equipment (100) works in conjunction with a visualization system to guide placement of the magnet (110) at the target site for recanalization of the biliary stricture. The magnet (110), may be deployed at opposing ends of a biliary stricture to create a controlled recanalization channel via magnetic attraction. The deployment process can be performed using endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic biliary drainage (PTBD), or a combination of both. Magnets may be retrieved following recanalization using biopsy forceps or allowed to pass naturally through the digestive tract, avoiding permanent implantation.

The utility model discloses a biliary tract inside and outside drainage device which comprises a drainage catheter, a fixing stay wire and a hard sleeve. The drainage catheter is composed of an inner drainage area, a narrow section covering area, a shaping area and an outer drainage area, and the interior of the drainage catheter is of a hollow structure. One end of the inner drainage area is designed into a cylindrical cone; a clamping table is arranged at one end of the outer drainage area and used for connecting a cap or a drainage bag; side holes penetrating through the inner cavity are formed in the outer walls of the inner drainage area and the shaping area; a marker point is arranged between the rear end of the side hole of the inner drainage area and the narrow section coverage area; the shaping area is curled into a loop in a natural state, and the shaping area can be straightened through the hard sleeve; the narrow section coverage area is distributed between the inner drainage area and the shaping area; the fixing stay wire comprises a fixing piece and a stay wire, and the tail end of the stay wire is connected with the fixing piece. The drainage catheter main body adopted by the utility model is made of a material with good biocompatibility; and internal drainage and external drainage can be realized. Multiple side holes are formed in the middle and the head end of the drainage tube, sufficient drainage is promoted, and infection risks are reduced.

The invention discloses an application of an OH2 oncolytic virus combined with a PD-1 inhibitor in preparation of an antitumor drug. The OH2 oncolytic virus and the PD-1 inhibitor are jointly applied to tumor treatment, and through the synergistic effect of the OH2 oncolytic virus and the PD-1 inhibitor, the anti-tumor immune response is enhanced, and the treatment effect is improved. According to the combined treatment scheme, tumor cells can be directly killed, recurrence and metastasis of tumors can be inhibited by activating systemic immune response, and a new treatment choice is provided for tumor patients. In the application, the neutrophile granulocyte number level in the blood of a tumor patient is closely associated with the treatment effect of the anti-tumor medicine, the anti-tumor medicine can be used for evaluating the treatment effect, and the anti-tumor medicine is suitable for common tumor adaptations including colorectal cancer, esophageal cancer, head and neck tumor, gastric cancer, biliary tract system tumor, sarcoma, melanoma and other tumors.