200 results about "Biliary tract" patented technology

The utility model relates to a biliary tract woven stent, which comprises a woven stent formed by weaving one or a plurality of woven filaments, the woven filaments are wound along the axis in a positive and negative spiral line mode and interwoven with one another, and the mutually staggered woven filaments form a lap joint buckle structure capable of freely sliding or a hooking buckle structure limited in sliding at nodes. According to the technical scheme, the structure is reasonable, the stent can be degraded automatically while the radial supporting force of the stent is improved, and the stent taking-out operation is omitted.

The invention discloses an application of the number of neutrophils in predicting the curative effect of oncolytic viruses in treating tumors. In the application, the neutrophile granulocyte number level in the blood of a tumor patient is closely associated with the tumor treatment effect, and the applicable tumor syndromes are common, including melanoma, colorectal cancer, esophageal cancer, head and neck tumors, gastric cancer, biliary tract system tumors, sarcoma and other tumors. In the application, the critical value of the number of neutrophils for predicting the tumor treatment effect is 2 * 10 < 9 >-5.5 * 10 < 9 > / L, and the most preferable critical value is 4.0 * 10 < 9 > / L; the curative effect of OH2 single-drug treatment on tumor patients with the neutrophil number level below a critical value is better than that of tumor patients with the neutrophil number level above the critical value.

The invention provides an intraoperative real-time navigation system based on digital twinning, and relates to the technical field of digital twinning, and the system comprises a data collection module which is used for obtaining the three-dimensional form data of a liver and a biliary tract through an intraoperative ultrasonic imaging device, and collecting the elastic modulus distribution parameters of liver parenchyma and a bile duct wall; the construction registration module is used for constructing a real-time digital twin in the liver and gall area based on the three-dimensional form data and the elastic modulus distribution parameters, and carrying out multi-mode non-rigid registration on the digital twin and the liver surface topography and the vascular structure which are subjected to optical coherence tomography in the operation; therefore, a dynamic space mapping relation between the organ structure and the image data is established. According to the method, real-time navigation in the operation is realized through digital twinning, the obstacle avoidance path is updated, and the safety and efficiency in the operation are improved.

The invention provides a drainage device capable of measuring biliary tract pressure, and relates to the technical field of biliary tract drainage equipment. A drainage device capable of measuring biliary tract pressure comprises a drainage hose, a pressure measuring mechanism is arranged on the drainage hose and comprises a pressure measuring tube, and one end of the pressure measuring tube is connected with the drainage hose; one end of the piezometric tube is provided with plugging liquid, and the other end of the piezometric tube is provided with a sliding plug which is connected with a control rod; calibration liquid is arranged in the pressure measuring pipe. Compared with the prior art, the device is simple in structure, convenient to use and capable of effectively observing pressure and adjusting the pressure.

The invention discloses a liver, gall and pancreas patient symptom evaluation system based on multi-dimensional data, and relates to the technical field of liver, gall and pancreas symptom evaluation. The visual management platform is in communication connection with a data acquisition module, an abnormal symptom classification module, a symptom risk analysis module, a symptom risk classification module and a report generation module, and all the modules are in electric signal connection; the data acquisition module is used for collecting and preprocessing multi-dimensional index data of a liver function index, a biliary system index and a pancreas index of a patient. By integrating the multi-dimensional data of the liver function index, the biliary system index and the pancreas index, the health condition of the liver, gall and pancreas patient can be more comprehensively reflected, compared with a traditional single-dimensional evaluation method, the abnormal symptoms of the patient can be more accurately recognized, the possibility of misdiagnosis and missed diagnosis is reduced, and the diagnosis accuracy is improved. And personalized symptom risk assessment can be carried out according to specific data of each patient, so that the medical decision is more accurate.

The invention belongs to the technical field of biological medicines, and particularly relates to application of ganoderic acid A in preparation of a medicine for preventing and / or treating biliary atresia. The new application of ganoderic acid A in preparation of drugs for preventing and / or treating biliary atresia is found for the first time. The method comprises the following steps: within 24 hours after a BALB / c newborn mouse is born, inducing the formation of BA by intraperitoneal injection of RRV, and from the second day after intraperitoneal injection of RRV, carrying out intraperitoneal injection of Ganoderic Acid A on the mouse every day until the twelfth day, it can be observed that the survival time of BA mice treated by the Ganoderma Acid A is prolonged, the weight loss is obviously improved, the jaundice symptom is relieved, the liver function index is obviously improved, the infiltration number of inflammatory cells around the intrahepatic bile duct is obviously reduced, and the liver bile duct injury is relieved. The invention provides a new potential target and a treatment strategy for treatment of BA, and has potential clinical treatment significance.

The invention relates to a pharmaceutical formulation, e.g. a paediatric formulation, of odevixibat, which comprises a plurality of small particles. The formulation may be used in the treatment of liver diseases such as bile acid-dependent liver diseases, and particularly cholestatic liver diseases such as biliary atresia, progressive familial intrahepatic cholestasis (PFIC), Alagille syndrome (ALGS) and paediatric cholestatic pruritus. The invention also relates to a process for the preparation of the pharmaceutical formulation.

The utility model relates to the technical field of medical instruments, in particular to a multifunctional biliary tract drainage tube with double-cavity sacculus auxiliary expansion through a PTCD (percutaneous transluminal compact disc) way, which comprises a drainage tube, a sacculus expansion tube group, a water injection tube and a sacculus, the fixing shell set comprises a drainage tube fixing shell and a water injection tube fixing shell arranged on the periphery of the drainage tube fixing shell, the drainage tube fixing shell is connected with the drainage tube, and the water injection tube fixing shell is connected with the water injection tube; the internal and external intercommunication window is communicated with a first area on the drainage tube and a second area, corresponding to each other, on the water injection tube, so that bile outside the water injection tube flows into the drainage tube through the internal and external intercommunication window. The multifunctional biliary tract drainage tube for assisting expansion through the PTCD way double-cavity balloon integrates biliary tract expansion and bile drainage, operation is reduced, and operation cost can be greatly reduced.

The invention discloses an application of a pyroptosis inhibitor in preparation of a product for treating biliary atresia, the pyroptosis inhibitor 2-bromohexadecanoic acid has a certain treatment effect on biliary atresia mice, can significantly prolong the survival time of the mice, improve jaundice, improve the liver function of the mice, reduce the infiltration quantity of inflammatory cells around intrahepatic bile ducts, and can be used for treating the biliary atresia. A new potential target and a treatment strategy are provided for treatment of biliary atresia.

The invention discloses a magnetic control steerable guide wire and an ERCP biliary tract probing and calculus removing operation method thereof.The magnetic control steerable guide wire comprises a magnetic control guide wire body and an external electromagnetic coil, the magnetic control guide wire body comprises a head end magnetic control module, a flexible transition section, a guide wire body section and a near-end control handle, the tail end of the head end magnetic control module is connected with the flexible transition section, and the tail end of the guide wire body section is connected with the external electromagnetic coil; the tail end of the flexible transition section is connected with a guide wire main body section, the tail end of the guide wire main body section is connected with a near-end control handle, and the external electromagnetic coil comprises an annular coil and an insulating layer.By means of guide wire head end magnetic force control and external magnetic field guiding, the problem that guide wire intubation is difficult due to the fact that a gallbladder duct and a total hepatic duct form an angle is solved; and through magnetic control of the head end of the guide wire and guidance of an external magnetic field, the problem that the guide wire is difficult to intubate due to angulation of the gallbladder duct and the total hepatic duct is solved, and the success rate and the safety of taking out the biliary calculus are improved.

The invention discloses a drainage catheter for a biliary tract and a biliary tract negative pressure drainage system. The biliary tract negative pressure drainage system comprises a negative pressure instrument, a liquid storage device, a drainage catheter and a catheter fixator. Wherein the negative pressure instrument is used for providing negative pressure and carrying out pressure detection. The liquid storage device is connected with the negative pressure instrument, so that negative pressure is formed in the liquid storage device through the negative pressure instrument. The drainage catheter comprises a connector, a catheter body and a pull wire. The connector is used for being connected with a liquid storage device and used for conveying liquid into the liquid storage device. The tube body is connected with the connector and used for drainage of liquid. The stay wire is arranged in the tube body in a penetrating mode so as to pull the far end of the tube body to form a pigtail-shaped circle. The catheter fixator is connected with the catheter body of the drainage catheter and used for fixing the catheter body to the skin surface near the biliary tract. When the far end of the catheter body forms a pigtail-shaped circle, the center line of the drainage catheter and the center line of the drainage section are located in the same plane, so that the drainage tip does not protrude, and the safety of biliary tract drainage is effectively improved.

The utility model discloses a flexible bendable catheter for a fiber choledochoscope, which relates to the technical field of catheters, and comprises a first catheter body and a second catheter body, the opposite ends of the first catheter body and the second catheter body are provided with gooseneck bending tubes of an integrated structure, the lower end of the second catheter body is fixedly provided with a hose, and the hose is fixedly provided with a flexible pipe. The first pipe body, the second pipe body and the hose are each composed of an inner layer, a steel wire braid layer and an outer layer which are arranged from inside to outside, a mounting pipe is fixedly mounted on the left side of the outer surface of the first pipe body, and an external thread part is arranged on the left side of the outer surface of the mounting pipe. The gooseneck bending tube is arranged, so that the catheter is easy to bend, the inner layer, the steel wire braid layer and the outer layer are arranged, so that the catheter has the advantages of being flexible and bendable, the application range is wide, the steel wire braid layer improves fracture resistance, distortion resistance, compliance and elastic performance of the catheter, pushing force conduction is facilitated, torsion conduction can be improved, and the service life of the catheter is prolonged. The catheter can be bent into any shape, so that the catheter can pass through the biliary tract, and the catheter is flexible to control.

The utility model relates to a biliary tract drainage device which comprises a drainage tube, a catheter seat and a locking connector. The drainage tube comprises a tube body section and a pigtail section extending at the far end of the tube body section, the tube body section is provided with a central cavity and a plurality of peripheral cavities which extend in the length direction, and the pigtail section is provided with an inner cavity communicated with the central cavity. The near end of the catheter body section is fixedly connected with the catheter base, and the catheter base is detachably connected with the locking connector. A plurality of first drainage holes are formed in the side wall of the pigtail section, the first drainage holes are communicated with an inner cavity of the pigtail section, and when the pigtail section forms a pigtail ring, the first drainage holes are located in the inner side of the pigtail ring. A second drainage hole is formed in the side wall of the far side of the catheter body section and communicated with the central cavity. The locking connector is provided with an inner cavity extending in the length direction, and when the locking connector and the catheter base are in the assembled connection state, the inner cavity of the locking connector is at least communicated with the center cavity. According to the biliary tract drainage device, the size of the catheter connector can be reduced.

The utility model relates to a guide sheath for assisting a choledochoscope to enter and exit from a biliary tract, which comprises a guide sheath body, a guide sleeve and a guide sleeve, an inlet is arranged on one side of the guide sheath body, a channel is arranged in the guide sheath body, and a transition cambered surface is arranged between the channel and the inlet; a guide sheath tube; the connector component comprises a butt joint part and a rotating part, the guiding sheath tube is arranged on the side, away from the rotating part, of the butt joint part, a plurality of elastic pieces capable of elastically and constantly abutting against the transition cambered surface are arranged on the side, away from the butt joint part, of the rotating part, and a groove is formed in the outer side of the rotating part; and the limiting part is detachably connected with the guide sheath body and is used for blocking and limiting the butt joint part through the groove. When the guide sheath used for assisting the choledochoscope in entering and exiting from the biliary tract is used in cooperation with the choledochoscope, the angle adjustment requirement of the choledochoscope can be met, the guide sheath tube can be kept still, the situation that the guide sheath tube hurts the interior of the human body is avoided, and the guide sheath used for assisting the choledochoscope in entering and exiting from the biliary tract can be applied to a gall-stone operation.

The utility model discloses a multifunctional biliary tract internal and external drainage tube combination device applied to a patient suffering from hilum cholangiocarcinoma. A drainage catheter is transited from a shaping area and an elastic cabin area to an internal drainage area to form a cylindrical cone; side holes are formed in the inner drainage area and the shaping area; a marker point is arranged between the inner drainage area and the missile cabin area, the missile cabin area is distributed between the inner drainage area and the shaping area, a one-way valve is arranged at the contact position between the shaping area and the missile cabin area, a hole channel is formed in the outer wall, extending into the marker point from the missile cabin area along the one-way valve, of the missile cabin area, and the hole channel forms a missile cabin in the missile cabin area. The magazine is used for placing radioactive particles; the hard support is used in cooperation with the drainage catheter, the hard support penetrates into the outer drainage area and then is pulled to the end of the inner drainage area, and the curled part of the shaping area of the hard support is straightened. The utility model can realize internal and external drainage and achieve the purpose of local tumor treatment, and is simple and convenient to operate and easy for medical staff to use.

The invention discloses a biliary tract drainage tube with a particle carrying radiotherapy function. The biliary tract drainage tube comprises a tube body, a stay wire and a stay wire traction fastening device, a bendable pigtail section is arranged at the front end of the tube body, a drainage cavity and a particle cavity are axially arranged in the tube body, and drainage holes communicated with the outside and the drainage cavity are formed in the tube wall of the pigtail section. The stay wire extends to the pigtail section along the drainage cavity and passes through stay wire holes at the head and tail of the pigtail section, and two ends of the stay wire extend out of the rear end of the tube body and converge to the fastening device. The front end of a first connector sleeve of the fastening device is fixedly connected with the rear end of the tube body and communicated with the drainage cavity through a connector inner tube, and a second connector sleeve loosely sleeves the connector inner tube. One end of the pull wire is fixed to the first connector sleeve, the other end of the pull wire movably penetrates out of the second connector sleeve, the pigtail section can be bent by pulling the pull wire, the second connector sleeve is rotated to a set angle, the pull wire is clamped through angle dislocation, and the pigtail section is kept in the bent state. Bending of the pigtail section can be conveniently controlled, the anchoring state can be stably maintained, and the safety and reliability of clinical catheterization can be effectively improved.

Described herein is a method of treating biliary tract cancer (BTC) comprising administering to a subject a bispecific antigen-binding construct targeting HER2 or a bispecific antigen-binding construct (ADC) targeting HER2 linked to an auristatin analog.

The present invention relates to a method for treating cancer in a human subject. The method comprises: (a) orally administering enuracil to the subject at a dose of 30-60 mg / day; (b) orally administering capecitabine to the subject for consecutive 2-14 days at a dose of about 140-700 mg / day or a dose that provides a 5-FU exposure (AUC) of about 1500 h * ng / mL or greater at least 10 hours after step (a); and (c) repeating the steps (a) and (b) 3-14 days after the step (b). The pharmaceutical composition is suitable for treating colorectal cancer, gastrointestinal tumor, breast cancer, pancreatic cancer, head and neck cancer, lung cancer or advanced biliary tract cancer.

The present invention relates to an equipment for magnetic recanalization of benign biliary strictures. The equipment (100) includes a wire-guided magnet pusher tube (102a), atleast one magnet (110), and a magnet retrieval tube (102b). The equipment (100) works in conjunction with a visualization system to guide placement of the magnet (110) at the target site for recanalization of the biliary stricture. The magnet (110), may be deployed at opposing ends of a biliary stricture to create a controlled recanalization channel via magnetic attraction. The deployment process can be performed using endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic biliary drainage (PTBD), or a combination of both. Magnets may be retrieved following recanalization using biopsy forceps or allowed to pass naturally through the digestive tract, avoiding permanent implantation.

The utility model discloses a biliary tract inside and outside drainage device which comprises a drainage catheter, a fixing stay wire and a hard sleeve. The drainage catheter is composed of an inner drainage area, a narrow section covering area, a shaping area and an outer drainage area, and the interior of the drainage catheter is of a hollow structure. One end of the inner drainage area is designed into a cylindrical cone; a clamping table is arranged at one end of the outer drainage area and used for connecting a cap or a drainage bag; side holes penetrating through the inner cavity are formed in the outer walls of the inner drainage area and the shaping area; a marker point is arranged between the rear end of the side hole of the inner drainage area and the narrow section coverage area; the shaping area is curled into a loop in a natural state, and the shaping area can be straightened through the hard sleeve; the narrow section coverage area is distributed between the inner drainage area and the shaping area; the fixing stay wire comprises a fixing piece and a stay wire, and the tail end of the stay wire is connected with the fixing piece. The drainage catheter main body adopted by the utility model is made of a material with good biocompatibility; and internal drainage and external drainage can be realized. Multiple side holes are formed in the middle and the head end of the drainage tube, sufficient drainage is promoted, and infection risks are reduced.

The invention discloses an application of an OH2 oncolytic virus combined with a PD-1 inhibitor in preparation of an antitumor drug. The OH2 oncolytic virus and the PD-1 inhibitor are jointly applied to tumor treatment, and through the synergistic effect of the OH2 oncolytic virus and the PD-1 inhibitor, the anti-tumor immune response is enhanced, and the treatment effect is improved. According to the combined treatment scheme, tumor cells can be directly killed, recurrence and metastasis of tumors can be inhibited by activating systemic immune response, and a new treatment choice is provided for tumor patients. In the application, the neutrophile granulocyte number level in the blood of a tumor patient is closely associated with the treatment effect of the anti-tumor medicine, the anti-tumor medicine can be used for evaluating the treatment effect, and the anti-tumor medicine is suitable for common tumor adaptations including colorectal cancer, esophageal cancer, head and neck tumor, gastric cancer, biliary tract system tumor, sarcoma, melanoma and other tumors.

The invention relates to the technical field of medical instruments, and discloses a visual biliary tract rotary cutting biopsy expansion system assembly which comprises a conical sleeve, a visual mechanism is fixedly connected to the interior of the conical sleeve, a holding mechanism is installed on the left side of the visual mechanism, a rotary cutting mechanism is installed at the left end of the holding mechanism, and the visual mechanism comprises a cable. The exterior of the cable is fixedly connected to the interior of the conical sleeve, the top end of the cable is fixedly connected with a golden finger, the left end of the conical sleeve is fixedly connected with a protection assembly, the left end of the protection assembly is fixedly connected with a Luer lock cap, and the interior of the protection assembly is fixedly connected with an insertion pipe; a light source is fixedly connected into the protection assembly. The inside of the biliary tract is uniformly and sufficiently illuminated through the light source, a clear observation view is provided for a doctor, the doctor can accurately judge the illness state, and the situation that the positive rate of hepatopathic bile duct malignant stenosis biopsy is not high is reduced.

The invention provides a kit or device for detecting biliary tract cancer, and a detection method. The present invention relates to: a kit or device for detecting biliary tract cancer, which contains a nucleic acid capable of specifically binding to miRNA in a specimen of a subject; and a method for detecting biliary tract cancer, which includes measuring the miRNA in vitro.

The present application relates to the field of medical immunology technology, and more particularly to biomarkers and their application in the assessment of liver damage in end-stage liver disease. In the present application, the proportion of CCR7+CD8+ T cells in CD8+ T cells is used as a marker for the assessment of liver damage in end-stage liver disease, which can reflect the liver immune status of end-stage liver disease, especially the assessment of the degree of liver damage, has high specificity and sensitivity, and provides a scientific basis for the development of clinical individualized treatment plan, and has good practical application value. At the same time, while reflecting the liver damage process of the patient, it can also reflect the immune status of the patient's liver, and can provide certain theoretical basis for slowing down the disease progression of subsequent biliary atresia and other end-stage liver disease patients with liver damage.

The utility model discloses a kind of anti-coming-off pipe device for clinical biliary tract drainage tube, it is related to medical instrument field, specifically for a kind of anti-coming-off pipe device for clinical biliary tract drainage tube, including the fixing plate for fixing biliary tract drainage tube, the both sides of the fixing plate are respectively equipped with adjusting groove, the fixing plate is equipped with the positioning column of adjusting groove insertion, the tail end of the positioning column is equipped with positioning plate, the sliding slot that is equipped with with positioning plate cooperation on fixing plate, the side of the fixing plate is equipped with the buckle plate that is with positioning column cooperation, two described buckle plate between are equipped with the pull rope for fixing biliary tract drainage tube joint, the utility model solves the biliary tract drainage tube of current clinical use, it is easy to influence the normal flow guide of biliary tract drainage tube, but because pipeline is long also easy to sway, it is easy to scratch patient skin, there is another common way is just with a rope to bind the interface of the other end of drainage tube, but the tightness of biliary tract drainage tube cannot be adjusted using this way.

The present disclosure relates to animal models simulating human biliary atresia. The model includes a large animal treated with an agent causing sclerosis of intrahepatic bile ducts in the animal to simulate human bile duct injury.

The present application relates to the technical field of biotechnology, more particularly to a biomarker for distinguishing benign biliary disease and cholangiocarcinoma and application thereof. The biomarker for distinguishing benign biliary disease and cholangiocarcinoma provided by the present application comprises 20 kinds of lipids and / or 5 kinds of polypeptides, and the single lipid group or single polypeptide group is used as a biomarker to distinguish benign biliary disease and cholangiocarcinoma, which has high sensitivity. When the lipid group and the polypeptide group are used as multi-group biomarkers, the sensitivity and accuracy of the discrimination can be further improved. In addition, the biomarker combination provided by the present application exists in serum, which is more suitable for non-invasive collection. The reagent or kit prepared based on the biomarker combination is more convenient for popularization and use. The risk prediction model for benign biliary disease and cholangiocarcinoma constructed based on the above biomarker has higher accuracy compared with the existing CA19-9 marker method, whether it is a single omics model or a double omics model.

The present invention relates to imidazo[1,2-a]pyridine and [1,2,4]triazolo[1, 5-a]pyridine derivatives of formula (I) or a salt thereof. The present compounds are inhibitors of TLR9 and useful in treating preventing, or slowing fibrotic diseases, such as e.g. liver fibrosis, renal fibrosis, biliary fibrosis or pancreatic fibrosis, nonalcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), chronic kidney disease, diabetic kidney disease, primary sclerosing cholangitis (PSC) or primary biliary cirrhosis (PBC), or idiopathic pulmonary fibrosis (IPF).

Described herein is a method of treating biliary tract cancer (BTC) comprising administering a bispecific antigen-binding construct targeting HER2 or a bispecific antigen-binding construct targeting HER2 linked to an auristatin analogue (ADC) to a subject.

The invention discloses a prognostic scoring method and system for predicting advanced biliary tract malignant tumor immunotherapy, and belongs to the technical field of advanced biliary tract malignant tumor immunotherapy. The method comprises the following steps: firstly, generating random replacement copies for real variables to obtain shadow variables, and classifying the real variables into related classes by comparing importance scores of the random replacement copies and the shadow variables; real variables in related classes are screened based on LASSO regression coefficients, and a variable set is formed; combining the variables in the set, and screening out a variable combination corresponding to a minimum AIC value model according to an AIC criterion to obtain a prognosis key variable set; calculating an index score according to the COX regression coefficient of each real variable; and finally, adding the index scores of the variables in the prognosis key variable set of each patient to obtain a prognosis BICCAPS score. Through three-step progressive screening of the random forest algorithm, the LASSO and the optimal subset method, the problems of variable screening, colinearity and model conciseness in high-dimensional clinical data modeling are solved.