267 results about "Human blood" patented technology

The invention discloses a positioning support convenient to fix and safe to take out in a human blood vessel, and relates to the technical field of surgical operation medical instruments. According to the positioning support, a plurality of positioning thorns with tips are arranged on a metal wire support, and each positioning thorn comprises a metal inner wire and a coating layer; the inner metal wire is connected with a metal wire of the metal wire stent, the diameter of the inner metal wire is smaller than that of the metal wire of the metal wire stent, the coating layer is conical and is made of degradable materials, a preset distance is reserved between the tip end of the inner metal wire and the tip end of the coating layer, and a spiral part is formed in the middle of the inner metal wire; after the coating layer is degraded, the spiral part is changed into a stretching state from a compressed state, the metal inner wire penetrates into the blood vessel wall, and a preset gap is formed between the blood vessel wall surface and the surface of the metal wire stent. The support can be reliably fixed and safely taken out.

The invention discloses a method for constructing a health influence prediction model based on multi-source air data coupling, and relates to the technical field of air quality health monitoring, and the method comprises the steps: obtaining multi-source air environment data in a selected space as an environment index, and obtaining a multi-source physiological signal of a person in the selected space as a physiological index; on the basis of the feature vectors of the environment indexes and the physiological indexes, the coupling relation between the air environment features and the physiological features is constructed, modeling is conducted on the nonlinear coupling relation between the air features and the physiological features through a time sequence deep learning model, and the action rule of air pollution accumulative exposure on dynamic changes of the physiological indexes is captured. Through feature extraction and cross-modal coupling, the comprehensive influence rule of air pollution on the blood pressure, blood oxygen, body temperature, heart rate, heart rate variability and blood glucose physiological indexes of the human body can be revealed, and dynamic prediction of health risks can be achieved through a deep learning model.

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

The utility model provides a miniature extracorporeal membrane lung oxygenation device which comprises a circulating pump, an oxygenator and a heat preservation device which are respectively arranged on a base, a liquid medium to be tested is filled in the heat preservation device, the liquid medium to be tested is kept at a constant temperature through the heat preservation device, and an outlet end of the heat preservation device is communicated to an inlet end of the oxygenator through a first pipeline. The outlet end of the oxygenator is communicated to the inlet end of the heat preservation device through a second pipeline, a circulating pump is installed on the first pipeline, an oxygen passing hole is formed in the middle of the oxygenator, an air inlet pipe is installed in the oxygen passing hole, and the air inlet pipe is connected to air supply equipment. According to the miniature extracorporeal membrane oxygenation device, blood to be tested is subjected to heat preservation through the heat preservation device, then blood circulation of a human body is simulated in vitro through the circulating pump, important data support is provided for research and development of an ECMO oxygenator, meanwhile, the research and development progress of an ECMO overall sleeve bag can be greatly accelerated, the test cost is reduced, and the test efficiency is improved. The test efficiency is improved.

The utility model discloses a device for preparing platelet-rich plasma suspension and gel containing blood cells. Comprising a fixing frame, at least one rapid clamping pipe clamp installed on the fixing frame, a vacuum centrifugal pipe clamped in the rapid clamping pipe clamp, and two suction devices capable of being inserted into the centrifugal pipe from the top or the bottom of the centrifugal pipe. The pusher is used for pushing the aspirator to be inserted into the centrifugal tube; the rotating mechanism is used for driving the pusher to rotate so as to enable the aspirator to face the top or the bottom of the centrifugal tube; the utility model solves the problems of blood pollution, manual operation error and low extraction rate in the manual operation process in the prior art, retains all blood platelets and white blood cells in the blood, retains red blood cells in normal proportion and most plasma proteins, and improves the extraction efficiency. Moreover, the concentration of platelets and leukocytes is constantly about 4 times of the concentration of blood of common normal people, the functions of erythrocyte components are reserved, and the functional effects of various components in the blood can be better exerted.

The invention provides a calibration method for real-time dynamic blood glucose monitoring. The calibration method comprises the steps that 1, weak current signals generated by a glucose sensitive electrode are obtained regularly; 2, filtering the detected weak current signal by adopting a sliding window double-layer screening algorithm; 3, monitoring the body temperature of the human body, compensating the temperature based on the filtered weak current value, and estimating the glucose concentration after temperature compensation; 4, monitoring the PH value of the human blood, compensating the PH value according to the filtered weak current value, and estimating the glucose concentration after PH value compensation; and 5, combining the glucose concentrations after temperature and pH value compensation, and carrying out filtering processing on the combined glucose concentrations by adopting a parameter compensation filtering algorithm to obtain a final glucose concentration estimation result.

The invention relates to the technical field of detection, and discloses a detection method and application of p-phenylenediamine antioxidants and quinone derivatives thereof, and the method comprises the following steps: taking a blood sample or a tissue sample, placing in a centrifuge tube, adding a recovery rate indicator solution and a glutathione solution, adding an extraction solvent, extracting twice, and combining the two solutions; centrifuging for 4-6 minutes at the speed of 3000-4500 rpm after each extraction, and combining the two extracts to obtain an extract to be detected; concentrating the to-be-detected extracting solution to be dry under soft nitrogen to obtain a to-be-detected concentrated dry substance; purifying with / without an HLB column; further concentrating the eluent, adding acetonitrile for redissolving, passing through an organic filter membrane, putting into a small sample injection bottle, and concentrating again; adding an internal standard solution to a constant volume to obtain a to-be-detected sample solution; and finally, detecting the sample solution to be detected by using an ultra-high performance liquid chromatography system and a mass spectrometer. According to the invention, the blank of no corresponding detection method for various PPDs and PPD-Qs in human blood and tissues is filled up.

The invention provides a kind of gel material, including the following components: agar, carrageenan, konjac gum, additives; The mass ratio of described agar, carrageenan, konjac gum is 18-22:1-5:1-5; The described additives include potassium dihydrogen phosphate, potassium sorbate, food coloring. The venipuncture model of the present invention is a highly simulated human blood vessel model, which can simulate real human blood vessel structure, so that learners can perform practical operation in a simulated environment, improve learning effect, adopt agar as main material, simple to make, with low cost, convenient for large-scale production and promotion, single model single point can actually enter needle puncture and reach more than 70 times, improve mold service life, and reduce cost.

The invention belongs to the technical field of tumor resistance, and particularly relates to a cabazitaxel albumin composition and application thereof. The cabazitaxel albumin composition comprises cabazitaxel and human serum albumin, and does not contain a surfactant; the solution is a clear solution in a liquid state; the present invention relates to a Cabazitaxel injection for use in the treatment of a cancer patient by infusion administration, the dosage of Cabazitaxel infused to said patient being about 10-40 mg / m2, preferably 20 mg / m2 or 25 mg / m2, optionally in combination with a corticoid, such as prednisone, optionally repeatedly administered to said patient at a new cycle per 3 weeks, having lower adverse effects than originally developed Cabazitaxel injections, and more particularly to a Cabazitaxel injection for use in the treatment of cancer patients. And a higher disease control rate is achieved for patients with advanced solid tumors.

1. Name of the product in this design: Electronic blood pressure monitor (14). 2. Purpose of this design: For measuring human blood pressure. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. The name of this design product: Blood Pressure Monitor (Flip Cover). 2. Application of this product: Suitable for measuring human blood pressure data at home. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The application discloses an albumin nano-drug based on HSP90 inhibitor and a preparation method and application thereof, and belongs to the technical field of medicines.The short peptide A6 is modified to human blood albumin through a connecting chain, and the human blood albumin modified by the A6 is self-assembled with geldanamycin derivative G2111 in the presence of an organic solvent, so that the G2111 is combined to the hydrophobic region of the human blood albumin through a non-covalent bond, effective loading of the G2111 is realized, the solubility of the geldanamycin derivative is improved, the drug is targetedly released into cancer cells with high expression of CD44, the targeted accumulation of the drug in tumor tissues is enhanced, damage to other normal tissues and cells caused by off-target effects of the drug is avoided, the albumin nano-drug can be simultaneously used for chemotherapy of leukemia and solid tumors, and has important practical significance.

The invention relates to the technical field of drug detection, in particular to a molecularly imprinted sensor for quantitatively detecting olanzapine in human blood as well as a preparation method and application of the molecularly imprinted sensor. Au-Pt NSF is deposited on the surface of a substrate electrode through an HBDT method, then a molecularly imprinted polyaniline layer is prepared through electro-polymerization, and the molecularly imprinted sensor is formed. A classical redox probe potassium hexacyanoferrate is used as a tool, and DPV is used for monitoring current change (delta I) caused by olanzapine addition, so that sensitive quantitative detection of olanzapine is realized. The sensor prepared by the invention shows a good linear relationship to olanzapine in the concentration ranges of 0.005-0.4 mu M and 0.4-10 mu M, the detection limit is 0.94 nM, and the sensor has high reproducibility and stability (relative standard deviation RSDlt;

According to the pulsating anti-load pants and the simplified air bag heart assisting device, by adding the anti-load clothes and the pulsating and blood pumping functions of the anti-load pants, the standing anti-load pants during cruising are changed into pulsating pressurizing pants with time control air valve pulsating type inflation and deflation or left and right air bags alternately inflated and deflated; the thick and long blood vessels of the lower limbs and the one-way valves on the inner walls of the thick and long blood vessels of the lower limbs are extruded to pump blood to become a second external heart; a simplified air bag heart assisting device is a pulsating anti-load pants reduced configuration scheme, outer-layer clothes and pants of anti-load pants are removed, and the simplified air bag heart assisting device is simplified into a crus air bag or a thigh and crus communicated air bag sewed nylon fastener tape device, and left and right leg air bag air conveying rubber pipes are connected with two electromagnetic three-way valves respectively and then are combined through rubber pipes to be connected with an air pump. Two-way power-on and power-off of a time relay are used for controlling left and right electromagnetic valves or improved valves to be connected with air bags, an air pump and an external tee joint, so that left and right leg air bags are inflated and deflated in turn; the invention can be used as heart-aiding anti-load trousers and heart-aiding fitness equipment, and can improve the blood circulation of the human body.

FIELD: pharmacology.SUBSTANCE invention can be used to determine the concentration of an anti-tuberculosis drug in blood serum. The method for determining the concentration of bedaquiline in the blood serum in patients with tuberculosis or mycobacteriosis is that whole blood samples are centrifuged at 3000 rpm for 20 minutes, then the blood plasma is collected in sterile 1.5 mL Eppendorf tubes, then 900 mcL of acetonitrile are added to 300 mcL of plasma and centrifuged at 13500g for 15 minutes, then 1 mL of the supernatant is transferred to a chromatographic vial and make the assay by UHPLC MS / MS using an Athena UHPLC C18, 1.8 mcM, 120A, 2.1×100 mm chromatography column, when using an aqueous solution containing 5 g / L of ammonium acetate, 25 ml / L of concentrated acetic acid, 2 ml / L trifluoroacetic acid as mobile phase A and 100% acetonitrile as mobile phase B, the concentration of bedaquiline is determined using a pre-plotted calibration curve.EFFECT: determination of bedaquiline in human blood plasma in a time not exceeding 6 minutes.1 cl, 9 dwg, 6 tbl

The invention relates to a method for avoiding a human body pre-stored anti-PEG antibody and application of a terminal hydroxyl group-containing PEGylated nano-carrier in preparation of a medicine for avoiding the human body pre-stored anti-PEG antibody. The composition contains a terminal hydroxyl group-containing PEGylated nano-carrier and a nano-preparation. The terminal hydroxyl group-containing PEGylated nano-carrier and the nano-preparation are low in combination with the anti-PEG antibody pre-stored in the human body, so that the anti-PEG antibody can be prevented from being quickly cleared in the blood of the human body, and the treatment effect can be better exerted. Besides, the PEGylated nano-carrier containing terminal hydroxyl and the nano-preparation can relieve complement activation by avoiding combination with a pre-stored anti-PEG antibody in human blood, so that side effects such as clinical injection reaction and the like are relieved.

The invention relates to the technical field of medical instrument detection, and particularly provides a portable glucometer calibration device and a detection method. The device is designed based on an adjustable microampere-level constant current source circuit, a chemical reaction between human body blood sugar and portable glucometer test paper is simulated to generate a micro-current signal, and the micro-current signal and a to-be-tested glucometer form a current loop through an interface of the calibration device. Wherein a micro-current signal output by the constant current source keeps a linear corresponding relation with the blood glucose concentration value and can be used as a preset standard value. By comparing the deviation between the preset standard value of the calibration device and the measured value of the glucometer, the measurement error of the measured instrument can be calculated. Compared with a traditional calibration mode, the device adopts a constant current control technology of an operational amplifier framework, accurate mapping of microampere-level current and blood glucose concentration is achieved, and the blood glucose meter device can be effectively calibrated by comparing the actually measured blood glucose concentration of the blood glucose meter to be detected with the standard blood glucose concentration set by the detection device. The product can provide a convenient glucometer calibration device for medical institutions and individual users.

1. The name of the design product: human blood sample analysis report graphical user interface for electronic equipment. 2. The use of the design product: for an electronic device. 3. The design points of the design product: in the graphical user interface. 4. The picture or photo that best indicates the design points: front view. 5. Other views are conventional designs, and other views are omitted. 6. The use of the graphical user interface: the interface is used for human blood sample data processing and disease diagnosis analysis. The front view is the initial interface. Interface change state diagram 1 is the interface presented after clicking the " " button in the upper right corner of the front view. Interface change state diagram 2 is the interface presented after clicking the "WBC Message" module in interface change state diagram 1 to display hidden information. Interface change state diagram 3 is the interface presented after clicking the "WBC" histogram in interface change state diagram 2. Interface change state diagram 4 is the interface presented after clicking the "RBC" histogram in interface change state diagram 3. 7. Other circumstances that need to be explained: the chart parameters in the design pictures and photos are used to reflect the interface effect. The chart parameters in the interface can change according to the actual use of the interface and the data reception.

The application belongs to the technical field of biotechnology, and discloses a nano antibody targeting B cell BCMA and application thereof. The amino acid sequences of the complementarity determining regions CDR1-CDR3 of the nano antibody are selected from SEQ ID NO. 1-12. The nano antibody provided by the application can specifically bind to B cells in human blood, especially activated plasma cells, so as to eliminate B cells producing pathological antibodies. Compared with traditional antibodies, the nano antibody provided by the application has a smaller molecular weight, high stability, low cost, easy expression and high expression amount, and is suitable for large-scale production. The nano antibody is combined with a solid-phase carrier in the application, so that B cells in blood can be targeted and eliminated, the number of B cells in blood of patients can be reduced in a short time, and the antibody level can be reduced, thereby improving the quality of life, reducing complications, and providing a new treatment option for patients who are ineffective or intolerant to traditional treatment.

The utility model relates to a simple and easy device for detecting human blood type, including flushing liquid containing container, detection subassembly and liquid suction piece, flushing liquid containing container has the containing cavity that contains flushing liquid, and containing cavity has top opening to allow detection subassembly inserts containing cavity, and containing cavity inboard wall is provided with first limit piece, the antibody for blood type detection is fixed in detection subassembly, the antibody can be combined with blood type antigen specificity, detection subassembly has first end and second end, liquid suction piece detachably fixed in second end of detection subassembly, detection subassembly outside wall is provided with second limit piece, wherein, when first end of detection subassembly inserts containing cavity, first limit piece and second limit piece cooperate and form longitudinal limit to fix detection subassembly in containing cavity, the utility model has the characteristics of simple operation, high accuracy, fast detection.

The invention belongs to the technical field of forensic medicine, and particularly relates to an mRNA marker combination, a product and application thereof and a forensic human menstrual blood or human menstrual blood spot detection method. The mRNA marker combination comprises a reference gene, a human blood specific mRNA marker and a human menstrual blood specific mRNA marker; the human blood specific mRNA marker is composed of HBA, HBB, ALAS2 and GYPA; the human menstrual blood specific mRNA marker is composed of MMP7, MMP10, SFRP4 and STC1. Standardized identification suggestions are given according to mRNA marker combination expression conditions, the problems of insufficient specificity, flow disorder and the like in the prior art are solved, human menstrual blood or human menstrual blood spots can be accurately distinguished from peripheral blood and other body fluids, cross-platform compatible standardized detection is realized, evidence support is provided for missing cases, and the detection method is suitable for clinical application. The method has important practical significance for improving the forensic physical evidence identification efficiency.

The invention relates to a method for determining the blood alcohol content (BAC) of a person in a vehicle (1), comprising the following steps: acquiring one or more images of the person in the vehicle (1) by means of one or more imaging units (2) arranged on the vehicle; the images are analyzed through a data processing unit (3), and human body data and face data of the person are determined through a database (5); calculating three-dimensional target vectors V1 and / or V2 of the mouth and / or nose of the person relative to an alcohol air detector (4) arranged in the vehicle (1) according to the facial data, in particular an infrared laser spectrometer for directional non-contact detection; the alcohol air detector (4) is started, and the expiratory alcohol concentration (BRAC) of the mouth and nose area of the person is measured in combination with the target vector V1 and / or V2; calculating a correction coefficient K in combination with human body data (especially gender, weight, age and / or height) of the person; and determining the blood alcohol content through a formula BAC = K * BRAC.

1. Name of the product in this design: Balloon Catheter (1). 2. Application of this design: It can be used for the dilation and treatment of human blood vessels or non-vascular cavities. 3. The key design feature of this product is its shape. 4. Images or photos that best illustrate the design key points: usage status reference diagrams.

1. The name of the design product: the measurement graphical user interface of sphygmomanometer. 2. The use of the design product: for measuring blood pressure. 3. The design points of the design product: the display content of the display panel. 4. The picture or photo that best shows the design points: top view. 5. The use of the graphical user interface: for the measurement interaction of sphygmomanometer. 6. The human-computer interaction mode of the graphical user interface: the interface of the top view shows the content displayed by the sphygmomanometer during the detection of human blood pressure, taking the example of the interface of the quantitative change of blood pressure value to "27mmHg"; during the detection of human blood pressure, the interface of the top view changes to the content displayed by the interfaces of change state diagram 1, change state diagram 2, and change state diagram 3 respectively with the change of blood pressure value; when the detection is completed, taking the example of the highest blood pressure value of 137mmHg, the lowest blood pressure value of 76mmHg, and the heart rate of 72, the interface jumps to change state diagram 4. 7. Other circumstances that need to be explained: the measurement graphical user interface of sphygmomanometer in the design picture requests protection, and the dashed line part does not belong to the content of the design to be protected.

The present application relates to the technical field of artificial implant medical device surface modification and middle ear hearing reconstruction, and discloses a processing method for enhancing the fixing stability of an artificial auditory ossicle prosthesis, the prosthesis and application. The method comprises the following steps: after the surface of the auditory ossicle prosthesis in contact with the middle ear tissue is cleaned, a polydopamine layer is formed in a basic dopamine solution, then gelatin, hyaluronic acid or cellulose sulfate is connected to the surface of the polydopamine layer through a carbodiimide activation system to form a viscous functional layer, and the dry sponge-like structure is obtained through freeze-drying. The functional layer can quickly rehydrate and restore the adhesion state after contacting with human blood or tissue fluid, thereby improving the fixing stability of the artificial auditory ossicle prosthesis in the initial implantation stage and reducing the risk of displacement or dislocation.

This invention relates to the field of electrochemical detection technology for vitamin E, specifically to an electrochemical detection device and method for vitamin E. The method includes: utilizing a detection system composed of a glassy carbon electrode, a saturated calomel electrode, and a platinum wire electrode; performing a series of optimizations and screenings to determine the SWV electrochemical detection method; and electrode pretreatment: using 0.05 μm alumina powder to perform circular polishing on the glassy carbon electrode in both directions for 3-4 minutes, followed by ultrasonic cleaning with anhydrous ethanol and pure water for three minutes each time. Finally, the electrode is scanned using the SWV method in a prepared buffer solution until it stabilizes. The beneficial effects are: this invention is convenient and simple to operate, has a simple formulation that greatly optimizes the detectable limit, has low manufacturing cost and is readily available, and requires no electrode modification; the lowest detectable concentration is far below the minimum normal range of vitamin E in human blood.

1. The name of the design product: full-automatic blood type analyzer. 2. The use of the design product: using column agglutination method, together with the matching detection reagent, for ABO system blood type typing, Rh system blood type typing, irregular antibody screening, cross matching and direct anti-human globulin test on human blood samples in clinical application. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

1. The name of the design product: multifunctional blood pressure nebulization integrated machine. 2. The use of the design product: for measuring human blood pressure and nebulization treatment. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

1. Name of the product of this design: Non-invasive Physiological Parameter Detector (B Series‑14 inches). 2. Application of this product: For non-invasive detection of human blood pressure, heart rate, hemodynamic waveform and other physiological parameters in small hospitals, community health hospitals and homes. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

1. Name of the product in this design: Finger Pulse Oximeter. 2. Purpose of this design: To measure human blood oxygen levels. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. The design for which protection is sought includes color.