519 results about "Human blood" patented technology

The invention relates to the technical field of health early warning, in particular to a human health early warning method and system based on physical examination data analysis, which comprises the following steps: collecting physical examination data of a human body, analyzing index changes of blood pressure, blood sugar, cholesterol and body mass index of the human body, sorting the physical examination data of the human body through time sequence sorting, and generating a time sequence sorting result. According to the method, time sequence sorting and spatial dimension evaluation are performed on the physical examination data, so that the health risk can be accurately identified and the early warning level can be dynamically evaluated, the data analysis precision is improved, the risk prediction dimension is increased, early warning is more timely and accurate, and the accuracy of early warning is improved by performing layout evaluation on the physical examination data points in a finite dimension space. Potential health abnormalities can be identified on multiple levels, and multi-dimensional analysis provides a new way for identifying complex health problems, so that health management is more active and predictable, health monitoring and risk management are optimized, and the health condition of a patient is improved.

The invention provides a kit and a detection method for detecting Alzheimer disease related proteins in human blood. The kit comprises a microsphere solution coupled with a p-Tau-217 capture antibody, a microsphere solution coupled with a p-Tau-231 capture antibody, a fluorescein PE coupling detection antibody solution and a diluent, the diluent is prepared from tris (hydroxymethyl) aminomethane, Triton X-100, sodium chloride and Proclin300; according to the kit provided by the invention, the accuracy of detecting the p-Tau-217 protein and the p-Tau-231 protein is improved by designing the microspheres, specifically detecting the p-Tau-217 protein and the p-Tau-231 protein and using a double-antibody sandwich detection method, clinical detection application is more convenient, and the kit is high in specificity, high in sensitivity, good in repeatability and relatively good in application prospect.

The invention relates to an imaging type non-contact gating signal obtaining method for a magnetic resonance system, and belongs to the field of physiological signal detection.The method comprises the steps that pulse and respiration signals of a magnetic resonance detection patient are collected through a camera, and face information of the patient is obtained through a reflector in a magnetic resonance instrument cavity; a living body skin detection technology is utilized to efficiently select a region of interest of the face of a patient, and an IPPG technology is combined to process a video image to obtain a curve of image gray along a time sequence; a motion detection algorithm is used for tracking micro motion of the chest, and stable and accurate breathing signals are extracted by combining frequency selection. By analyzing and quantifying pulse wave signals and delay of respiration signals and electrocardiosignals, the purpose of replacing electrocardiosignal R-peak gating triggering with pulse wave and respiration signal feature triggering is achieved. The invention provides an imaging type non-contact gating technology to solve the problems that traditional ECG and other contact gating technologies are easily affected by a strong static magnetic field, an alternating gradient magnetic field and a radio-frequency pulse electromagnetic field in a magnetic resonance imaging system, and motion artifacts can be generated on motion of fluid such as human blood, breathing and cardiac contraction. Therefore, the quality of a magnetic resonance imaging image is improved.

The invention provides a therapeutic drug monitoring kit and method and system, a magnetic bead extraction method is combined with LC-MS / MS detection to be applied to human blood drug concentration monitoring, a mixed magnetic bead solution containing phospholipid removal magnetic beads and to-be-detected drug adsorption magnetic beads is utilized to perform adsorption and extraction pretreatment on a to-be-detected drug in a sample, automatic treatment equipment is matched, and the concentration of the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug is detected. The pretreatment efficiency is high, the phospholipid content in the supernate is low, and the matrix effect and the chromatographic column washing pressure are greatly reduced. According to the therapeutic drug monitoring method provided by the invention, a unified pretreatment process is used, simultaneous extraction of multiple drugs is realized, and through a magnetic bead automatic extraction method, the pretreatment step of a sample can be rapidly completed, a therapeutic drug monitoring result can be rapidly obtained, the overall detection time is shortened, and the detection efficiency is improved. Therefore, a reliable laboratory examination basis is provided for individualized treatment.

The present invention belongs to the field of flexible electronics, and specifically is a flexible polymer ultrasonic probe. The flexible polymer ultrasonic probe of the present invention is a multi-layer structure, which includes a shielding layer, a backing layer, an upper electrode, a piezoelectric layer, a lower electrode, a matching layer, and a coupling layer from top to bottom; all functional layers are made of polymers and their composite materials, have very good flexibility, and can withstand complex deformations such as bending and twisting. The flexible polymer ultrasonic probe can emit ultrasonic waves under the excitation of electrical signals as an ultrasonic transmitting unit, and can also collect ultrasonic signals as an ultrasonic receiving unit. The flexible polymer ultrasonic probe can be made into a patch for industrial flaw detection of irregular surface objects and long-term health monitoring of the human body. For example, based on the ultrasonic Doppler principle, long-term continuous monitoring of blood flow velocity in human blood vessels can be achieved.

The invention discloses a positioning support convenient to fix and safe to take out in a human blood vessel, and relates to the technical field of surgical operation medical instruments. According to the positioning support, a plurality of positioning thorns with tips are arranged on a metal wire support, and each positioning thorn comprises a metal inner wire and a coating layer; the inner metal wire is connected with a metal wire of the metal wire stent, the diameter of the inner metal wire is smaller than that of the metal wire of the metal wire stent, the coating layer is conical and is made of degradable materials, a preset distance is reserved between the tip end of the inner metal wire and the tip end of the coating layer, and a spiral part is formed in the middle of the inner metal wire; after the coating layer is degraded, the spiral part is changed into a stretching state from a compressed state, the metal inner wire penetrates into the blood vessel wall, and a preset gap is formed between the blood vessel wall surface and the surface of the metal wire stent. The support can be reliably fixed and safely taken out.

The present invention belongs to the field of biotechnology, and specifically relates to an antibody targeting CD47 and its application. The anti-human CD47 antibody provided by the present invention can effectively bind to recombinant CD47 protein, block the binding of CD47 to its biological ligand SIRPa, and effectively identify and bind to CD47 positive tumor cells. At the same time, the CD47 antibody does not cause significant hemagglutination reaction and red blood cell binding of human red blood cells at high concentrations.

The invention discloses a non-enzymatic uric acid electrochemical sensor based on quaternary ammonium salt modified MXene, a method and application, and belongs to the technical field of sensors. The preparation method comprises the following steps: preparing an MXene material through an etching method; the preparation method comprises the following steps: modifying an MXene material by adopting quaternary ammonium salt to obtain a modified MXene material; a working electrode is modified with the modified MXene material, a reference electrode and a counter electrode are combined to form a three-electrode system, and the non-enzymatic uric acid electrochemical sensor based on quaternary ammonium salt modified MXene is obtained. The prepared non-enzymatic uric acid electrochemical sensor is excellent in performance, high in sensitivity and low in detection limit; the linear range is wide and covers the human blood uric acid concentration range; the stability is good, and the influence by temperature and pH is avoided; the biological compatibility is good, the antibacterial property is good, and the toxicity is low. The sensor can realize rapid and quantitative detection of human blood uric acid concentration, has excellent detection performance, and has no obvious difference with the detection result of a large biochemical analysis instrument.

The invention provides a method for treating COVID-19 patients. Therapeutic antibodies of certain types of antibodies to COVID-19 are identified early by targeted diagnostic testing can be given to other COVID-19 patients to enhance their recovery. This invention also identifies bacterial pathogens, particularly those that are resistant to antibiotics, faster. Data from deep RNA sequencing of human blood is used to create a faster diagnostic test for infections and associated antimicrobial resistance. This invention thus also allows for appropriate antibiotic treatment at an earlier time point. The invention further provides improvements to RNA sequencing that can make RNA sequencing useful for diagnostic and therapeutic methods of treating sepsis. RNA sequencing can identify bacterial pathogens directly from the blood of patients with those infections.

The invention provides a creatinine sensor based on an asymmetric Mach-Zehnder structure, and belongs to the technical field of biological optical sensing. The sensor comprises a PDMS lower cladding, a PMMA core layer and a PDMS upper cladding, the PMMA core layer comprises an input waveguide, a beam splitter, a modulation arm waveguide, a beam combiner and an output waveguide, and the modulation arm waveguide comprises a sensing arm and a reference arm which are unequal in width. The sensing arm adopts a suspended design and is windowed, and a creatininase mixed solution is fixed on the surface of the sensing arm so as to increase the response to the creatinine concentration. Through optimal design of the width of the reference arm, the sensitivity of the reference arm is reduced, and the phase change of an interference signal is mainly caused by the sensing arm, so that the sensing sensitivity is improved. The sensor can detect the creatinine concentration within the range of 0-110 [mu] moL / L, covers the physiological concentration range of creatinine in human blood, has the characteristics of high sensitivity and compact structure, and is suitable for wearable health detection application.

The invention discloses preparation and application of a novel diagnostic kit for a mitochondrial network regeneration function evaluation test, and in the invention, combined detection of related proteins DRP1, MFN2, OPA1 and TIM23 is carried out by utilizing four mitochondrial networks, so that the mitochondrial regeneration function state of sample cells is judged. The kit disclosed by the invention is used for detecting samples such as human blood, urine, cell cultures and tissues by utilizing an ELISA (Enzyme-Linked Immunosorbent Assay) method. Results show that the kit can accurately detect the content of four proteins so as to judge the function of sample mitochondria. The mitochondrial network regeneration capacity function evaluation kit based on a double-antibody sandwich method in an ELISA method can conveniently and accurately evaluate the mitochondrial network regeneration capacity in a human body specimen. The invention discloses preparation and application of the novel diagnostic kit for evaluating the regeneration function of the mitochondrial network. The diagnostic kit plays an auxiliary role in mitochondrial detection in scientific research and disease diagnosis and treatment. The method is applied to mitochondrial function evaluation in all diseases with abnormal cell mitochondrial functions.

The invention discloses a noninvasive blood glucose concentration prediction system and method based on a deep triplet network. Belongs to the technical field of blood glucose detection and particularly relates to the technical field of noninvasive blood glucose detection. The problem that a conventional noninvasive blood glucose concentration prediction method does not have universal applicability is solved. The system comprises a data acquisition module, a data processing module, a model building module and a prediction module. The data acquisition module is used for acquiring and preprocessing spectral characteristic data of the finger part of the volunteer; the data processing module divides the preprocessed data into a training set, a verification set and a test set; the model building module is used for building a noninvasive blood glucose concentration prediction model and training the noninvasive blood glucose concentration prediction model by using the data in the data processing module to obtain an optimal noninvasive blood glucose concentration prediction model; the noninvasive blood glucose concentration prediction model comprises a triple input network, an improved Transform network and an SVR (Support Vector Regression) regression prediction network; the prediction module is used for predicting the blood glucose concentration of the human body according to the optimal noninvasive blood glucose concentration prediction model.

The present invention belongs to the technical field of blood simulation fluid, and particularly relates to a women's menstrual blood simulation fluid. The women's menstrual blood simulation fluid is made of the following raw materials: tertiary water, inorganic sodium salt, acid-base regulator, thickener, simulation modifier, simulation regulator, preservative and red pigment. The formula of the women's menstrual blood simulation fluid of the present invention is scientific and reasonable. By adding the simulation modifier and cooperating with other components in the simulation fluid, a product that is better than the existing standard test fluid is obtained. Compared with the existing standard fluid, it is closer to the physical properties of human blood. Compared with human and animal blood materials, it has the advantages of not easy to agglomerate, easy to preserve, and cheaper. It has a good guiding significance in the determination of the absorption and penetration properties of sanitary napkins and high-absorbent resins.

The invention belongs to the technical field of medicines, and particularly relates to a composition containing mesenchymal stem cells and application of the composition in preparation of products for resisting premature ovarian failure. The invention relates to a composition containing mesenchymal stem cells. The umbilical cord mesenchymal stem cell gel is prepared from the following components in percentage by weight: 10 percent of umbilical cord mesenchymal stem cells, 4 to 6 percent of human serum albumin stock solution, 1 to 2 percent of ginkgo biloba extract, 1 to 3 percent of coix seed oil, 2 to 2.5 percent of flavonol glycoside, 1.1 to 1.3 percent of vitamin E, 0.4 to 0.8 percent of glutathione, 0.5 to 1.5 percent of sodium hyaluronate, 0.5 to 1.0 percent of phycocyanin, 1.2 to 1.8 percent of zinc gluconate, 0.5 to 0.8 percent of heparin calcium, 0.1 to 0.3 percent of pH regulator and the balance of normal saline. The composition disclosed by the invention can be used for preparing products for resisting premature ovarian failure and has a very good effect.

The invention discloses a method for constructing a health influence prediction model based on multi-source air data coupling, and relates to the technical field of air quality health monitoring, and the method comprises the steps: obtaining multi-source air environment data in a selected space as an environment index, and obtaining a multi-source physiological signal of a person in the selected space as a physiological index; on the basis of the feature vectors of the environment indexes and the physiological indexes, the coupling relation between the air environment features and the physiological features is constructed, modeling is conducted on the nonlinear coupling relation between the air features and the physiological features through a time sequence deep learning model, and the action rule of air pollution accumulative exposure on dynamic changes of the physiological indexes is captured. Through feature extraction and cross-modal coupling, the comprehensive influence rule of air pollution on the blood pressure, blood oxygen, body temperature, heart rate, heart rate variability and blood glucose physiological indexes of the human body can be revealed, and dynamic prediction of health risks can be achieved through a deep learning model.

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

The invention concerns a novel microassay device comprising a plurality of pillars functionalised using antibody specific for the isolation of extracellular vesicles (EVs), typically but not exclusively from human blood or cell culture media, and including electrodes for measuring impedance; wherein said pillars are made from, or coated with, a copolymer comprising, as copolymerized units, at least one polythiol monomer ('thiol monomer') and at least one polyalkene / alkyne monomer ('ene' monomer'), wherein the ratio of thiol to alkene / alkyne functional groups in said copolymer has an excess of alkene / alkyne functional groups, optionally from about 100:150 to 100:105; a method for the fabrication of said device; use of the device for tissue-selective isolation of EVs, and / or quantifying the amount of said EVs, and / or assaying the enzyme activity of said EVs, such as that of Cytochrome P450 enzymes or UDP-glucuronosyl transferases or, indeed, any other enzyme(s) contained in the cells or EVs; and a kit of parts including said device.

The invention relates to a specially selected strain and application thereof in cardiovascular and cerebrovascular maintenance. The invention provides a specially selected strain-prebiotic composition for enhancing and maintaining an ozone high-dose blood purification effect and application of the specially selected strain-prebiotic composition in establishment of an intestinal barrier function and health maintenance of heart and cerebral vessels. According to the invention, blood cell metabolism, immune system and antioxidant enzyme system can be activated by autologous blood circulation reinfusion, the state of the blood vessel wall is improved, and the physiological function of blood cells is enhanced; the specially selected targeted strain-prebiotic composition can regulate intestinal flora balance, establish an intestinal barrier function, maintain and accelerate metabolism of a human body, decompose blood fat and toxin garbage accumulated in the body, promote detoxification of the intestinal tract, purify the intestinal tract and reduce intestinal toxin substances entering the blood circulation of the human body through a portal system. According to the combination scheme, the blood purification effect can be remarkably improved, the blood fat index is remarkably improved, the purposes of recovering the blood vessel function and enhancing the human immune function are jointly achieved, a new technical scheme and means are provided for prevention and treatment of cardiovascular and cerebrovascular diseases, and wide application prospects are achieved.

The utility model provides a miniature extracorporeal membrane lung oxygenation device which comprises a circulating pump, an oxygenator and a heat preservation device which are respectively arranged on a base, a liquid medium to be tested is filled in the heat preservation device, the liquid medium to be tested is kept at a constant temperature through the heat preservation device, and an outlet end of the heat preservation device is communicated to an inlet end of the oxygenator through a first pipeline. The outlet end of the oxygenator is communicated to the inlet end of the heat preservation device through a second pipeline, a circulating pump is installed on the first pipeline, an oxygen passing hole is formed in the middle of the oxygenator, an air inlet pipe is installed in the oxygen passing hole, and the air inlet pipe is connected to air supply equipment. According to the miniature extracorporeal membrane oxygenation device, blood to be tested is subjected to heat preservation through the heat preservation device, then blood circulation of a human body is simulated in vitro through the circulating pump, important data support is provided for research and development of an ECMO oxygenator, meanwhile, the research and development progress of an ECMO overall sleeve bag can be greatly accelerated, the test cost is reduced, and the test efficiency is improved. The test efficiency is improved.

The invention provides a multi-channel viscoelastic micro-fluidic chip, a manufacturing method and a method for separating MCF-7 cells. The multi-channel viscoelastic micro-fluidic chip comprises a first multi-stage shunting module, a pipette, a second multi-stage shunting module, a single-stage viscoelastic micro-fluidic sub-module and a third multi-stage shunting module, the first multi-stage shunting module is connected with one inlet of the single-stage viscoelastic micro-fluidic sub-module through a pipette; the second multi-stage shunting module is connected with the other inlet of the single-stage viscoelastic micro-fluidic sub-module; and the outlet of the single-stage viscoelastic micro-fluidic sub-module is connected with the third multi-stage shunting module. According to the method, the PEO solution is used as sheath fluid, and the action of elastic force is introduced to cells, so that CTC can be directly separated from undiluted human blood in an ultrahigh-flux manner, and the limitation that erythrocytes need to be split and a blood sample needs to be diluted by dozens of times before cell separation in traditional inertial microfluidics is broken through; and the complexity of operation and the risk of sample pollution are reduced.

Provided herein are settable and non-settable compositions for use in surgical procedures comprising a variety of disclosed particles and optionally including previously unclotted, lyophilized, optionally crosslinked mammalian blood plasma. Also provided are related compositions, including surgical kits and packages, as well as methods of making and using the compositions.

The invention provides a biomarker for early Alzheimer's disease detection, a kit, a preparation method and application. The kit mainly contains seven capture antibodies and detection antibodies which can be specifically combined with human blood metabolites, has the characteristics of high detection sensitivity, high specificity and high accuracy, not only can distinguish blood samples of forgetting mild cognitive impairment patients, but also can identify early-stage Alzheimer's disease patients.

The invention discloses a device for realizing blood leakage monitoring by using surface acoustic waves in a blood purification system, which comprises a sound wave information detection module, an early warning model design module, a sensing performance evaluation module and a remote response optimization module, and is characterized in that a human body blood vessel distribution model is constructed and a blood leakage monitoring early warning model is designed; the blood leakage prediction risk degree is evaluated, human blood vessel blood leakage risk marking is carried out, blood leakage risk monitoring of different puncture points of hemodialysis is achieved, pertinence and accuracy of blood leakage monitoring are guaranteed, and then the blood leakage risk of different puncture points of hemodialysis is monitored by comprehensively evaluating the sensing performance of the surface acoustic wave filter and introducing interference factor analysis. Therefore, risk prediction and device optimization management are carried out on the sensing performance of the surface acoustic wave filter in a long-term use state, continuous and stable sensing performance of the surface acoustic wave filter is ensured, and finally blood leakage monitoring with high pertinence, high accuracy and good stability in a blood purification system is realized by using surface acoustic waves.

The invention belongs to the technical field of pharmaceutical chemistry, and particularly relates to a benzotriazole derivative serving as a CDKs inhibitor, a pharmaceutical composition of the benzotriazole derivative and application of the benzotriazole derivative to preparation of antitumor drugs. The benzotriazole derivative disclosed by the invention has relatively strong activity of inhibiting CDK9 and other CDK subtypes, has relatively strong anti-tumor activity, and has relatively strong inhibitory activity on cell proliferation of human hematologic tumor cells K562 and colorectal cancer cells HCT116. The structure of the benzotriazole derivative disclosed by the invention is as shown in general formula I: # imgabs0 #

The utility model discloses a device for preparing platelet-rich plasma suspension and gel containing blood cells. Comprising a fixing frame, at least one rapid clamping pipe clamp installed on the fixing frame, a vacuum centrifugal pipe clamped in the rapid clamping pipe clamp, and two suction devices capable of being inserted into the centrifugal pipe from the top or the bottom of the centrifugal pipe. The pusher is used for pushing the aspirator to be inserted into the centrifugal tube; the rotating mechanism is used for driving the pusher to rotate so as to enable the aspirator to face the top or the bottom of the centrifugal tube; the utility model solves the problems of blood pollution, manual operation error and low extraction rate in the manual operation process in the prior art, retains all blood platelets and white blood cells in the blood, retains red blood cells in normal proportion and most plasma proteins, and improves the extraction efficiency. Moreover, the concentration of platelets and leukocytes is constantly about 4 times of the concentration of blood of common normal people, the functions of erythrocyte components are reserved, and the functional effects of various components in the blood can be better exerted.

The invention provides a motor control device and method and a ventricular assist device, and relates to the field of medical instrument control. The motor control device comprises a motor working state monitoring module and an abnormity correction module, and the motor working state monitoring module is used for monitoring whether a motor is in an abnormal working state based on a motor working index; the abnormity correction module is used for generating a current impact instruction when the motor is in an abnormal working state; wherein the current impact instruction is used for adjusting the current current of the motor into impact current, and the impact current is greater than the current current. By using the motor control device provided by the embodiment of the invention, the correction of the abnormal working state of the motor can be realized under the conditions that the loss of the motor is relatively small and the influence on a human body is relatively small; the motor control device provided by the embodiment of the invention is used for controlling the motor of the ventricular assist device, so that the loss of the motor can be reduced, and the influence on human blood cells can also be reduced.

The invention provides a calibration method for real-time dynamic blood glucose monitoring. The calibration method comprises the steps that 1, weak current signals generated by a glucose sensitive electrode are obtained regularly; 2, filtering the detected weak current signal by adopting a sliding window double-layer screening algorithm; 3, monitoring the body temperature of the human body, compensating the temperature based on the filtered weak current value, and estimating the glucose concentration after temperature compensation; 4, monitoring the PH value of the human blood, compensating the PH value according to the filtered weak current value, and estimating the glucose concentration after PH value compensation; and 5, combining the glucose concentrations after temperature and pH value compensation, and carrying out filtering processing on the combined glucose concentrations by adopting a parameter compensation filtering algorithm to obtain a final glucose concentration estimation result.

The invention relates to a method for separating out and condensing specific protein in liquid for dyeing and detection. The liquids include but are not limited to human samples, human blood, saliva, urine and the like. The liquid is diluted and its pH is raised or lowered to form a mixed liquid. Placing the mixed solution in an electrostatic field, moving the specific protein in the mixed solution to one side of the mixed solution, accurately dropwise adding an acidic or alkaline solution, adjusting the pH value of the mixed solution, enabling the pH value of the mixed solution to reach the isoelectric point of the specific protein, and enabling the specific protein to be separated out and precipitated on one side of the mixed solution. In addition, according to the sequence of the pH values from large to small or from small to large, the isoelectric points of all the specific proteins can be traversed in the process, and all the specific proteins can be separated out and precipitated in the same area of the mixed solution.

The utility model discloses an intravascular ultrasound catheter and an ultrasound diagnosis system, the intravascular ultrasound catheter comprises a tip end, an imaging tube section and a conveying tube section which are arranged in sequence from the far end to the near end, and the tip end, the imaging tube section and the conveying tube section are internally provided with guide wire cavities for a guide wire to penetrate; core part cavities are formed in the imaging pipe section and the conveying pipe section, transducer core parts are arranged in the core part cavities, and ultrasonic transducers are arranged at the far ends of the transducer core parts; a transition part is arranged at the far end of the conveying pipe section, so that the conveying pipe section can generate local deformation; the guide wire control component allows the guide wire to move in the operating state, inhibits the guide wire from moving in the locking state, and limits the guide wire at the position away from the ultrasonic transducer as a whole. The intravascular ultrasonic catheter can be bent according to the physiological curvature of a human blood vessel, has the capability of easily passing through a tortuous blood vessel, reduces the risk of pressing the blood vessel and peripheral tissues, effectively reduces the influence of signal shielding caused by a guide wire, and realizes full-angle scanning of the ultrasonic catheter.

The invention relates to the technical field of detection, and discloses a detection method and application of p-phenylenediamine antioxidants and quinone derivatives thereof, and the method comprises the following steps: taking a blood sample or a tissue sample, placing in a centrifuge tube, adding a recovery rate indicator solution and a glutathione solution, adding an extraction solvent, extracting twice, and combining the two solutions; centrifuging for 4-6 minutes at the speed of 3000-4500 rpm after each extraction, and combining the two extracts to obtain an extract to be detected; concentrating the to-be-detected extracting solution to be dry under soft nitrogen to obtain a to-be-detected concentrated dry substance; purifying with / without an HLB column; further concentrating the eluent, adding acetonitrile for redissolving, passing through an organic filter membrane, putting into a small sample injection bottle, and concentrating again; adding an internal standard solution to a constant volume to obtain a to-be-detected sample solution; and finally, detecting the sample solution to be detected by using an ultra-high performance liquid chromatography system and a mass spectrometer. According to the invention, the blank of no corresponding detection method for various PPDs and PPD-Qs in human blood and tissues is filled up.