380 results about "Human blood" patented technology

The invention relates to the technical field of health early warning, in particular to a human health early warning method and system based on physical examination data analysis, which comprises the following steps: collecting physical examination data of a human body, analyzing index changes of blood pressure, blood sugar, cholesterol and body mass index of the human body, sorting the physical examination data of the human body through time sequence sorting, and generating a time sequence sorting result. According to the method, time sequence sorting and spatial dimension evaluation are performed on the physical examination data, so that the health risk can be accurately identified and the early warning level can be dynamically evaluated, the data analysis precision is improved, the risk prediction dimension is increased, early warning is more timely and accurate, and the accuracy of early warning is improved by performing layout evaluation on the physical examination data points in a finite dimension space. Potential health abnormalities can be identified on multiple levels, and multi-dimensional analysis provides a new way for identifying complex health problems, so that health management is more active and predictable, health monitoring and risk management are optimized, and the health condition of a patient is improved.

The invention provides a therapeutic drug monitoring kit and method and system, a magnetic bead extraction method is combined with LC-MS / MS detection to be applied to human blood drug concentration monitoring, a mixed magnetic bead solution containing phospholipid removal magnetic beads and to-be-detected drug adsorption magnetic beads is utilized to perform adsorption and extraction pretreatment on a to-be-detected drug in a sample, automatic treatment equipment is matched, and the concentration of the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug is detected. The pretreatment efficiency is high, the phospholipid content in the supernate is low, and the matrix effect and the chromatographic column washing pressure are greatly reduced. According to the therapeutic drug monitoring method provided by the invention, a unified pretreatment process is used, simultaneous extraction of multiple drugs is realized, and through a magnetic bead automatic extraction method, the pretreatment step of a sample can be rapidly completed, a therapeutic drug monitoring result can be rapidly obtained, the overall detection time is shortened, and the detection efficiency is improved. Therefore, a reliable laboratory examination basis is provided for individualized treatment.

The invention discloses a positioning support convenient to fix and safe to take out in a human blood vessel, and relates to the technical field of surgical operation medical instruments. According to the positioning support, a plurality of positioning thorns with tips are arranged on a metal wire support, and each positioning thorn comprises a metal inner wire and a coating layer; the inner metal wire is connected with a metal wire of the metal wire stent, the diameter of the inner metal wire is smaller than that of the metal wire of the metal wire stent, the coating layer is conical and is made of degradable materials, a preset distance is reserved between the tip end of the inner metal wire and the tip end of the coating layer, and a spiral part is formed in the middle of the inner metal wire; after the coating layer is degraded, the spiral part is changed into a stretching state from a compressed state, the metal inner wire penetrates into the blood vessel wall, and a preset gap is formed between the blood vessel wall surface and the surface of the metal wire stent. The support can be reliably fixed and safely taken out.

The invention belongs to the technical field of medicines, and particularly relates to a composition containing mesenchymal stem cells and application of the composition in preparation of products for resisting premature ovarian failure. The invention relates to a composition containing mesenchymal stem cells. The umbilical cord mesenchymal stem cell gel is prepared from the following components in percentage by weight: 10 percent of umbilical cord mesenchymal stem cells, 4 to 6 percent of human serum albumin stock solution, 1 to 2 percent of ginkgo biloba extract, 1 to 3 percent of coix seed oil, 2 to 2.5 percent of flavonol glycoside, 1.1 to 1.3 percent of vitamin E, 0.4 to 0.8 percent of glutathione, 0.5 to 1.5 percent of sodium hyaluronate, 0.5 to 1.0 percent of phycocyanin, 1.2 to 1.8 percent of zinc gluconate, 0.5 to 0.8 percent of heparin calcium, 0.1 to 0.3 percent of pH regulator and the balance of normal saline. The composition disclosed by the invention can be used for preparing products for resisting premature ovarian failure and has a very good effect.

The invention discloses a method for constructing a health influence prediction model based on multi-source air data coupling, and relates to the technical field of air quality health monitoring, and the method comprises the steps: obtaining multi-source air environment data in a selected space as an environment index, and obtaining a multi-source physiological signal of a person in the selected space as a physiological index; on the basis of the feature vectors of the environment indexes and the physiological indexes, the coupling relation between the air environment features and the physiological features is constructed, modeling is conducted on the nonlinear coupling relation between the air features and the physiological features through a time sequence deep learning model, and the action rule of air pollution accumulative exposure on dynamic changes of the physiological indexes is captured. Through feature extraction and cross-modal coupling, the comprehensive influence rule of air pollution on the blood pressure, blood oxygen, body temperature, heart rate, heart rate variability and blood glucose physiological indexes of the human body can be revealed, and dynamic prediction of health risks can be achieved through a deep learning model.

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

The invention relates to a specially selected strain and application thereof in cardiovascular and cerebrovascular maintenance. The invention provides a specially selected strain-prebiotic composition for enhancing and maintaining an ozone high-dose blood purification effect and application of the specially selected strain-prebiotic composition in establishment of an intestinal barrier function and health maintenance of heart and cerebral vessels. According to the invention, blood cell metabolism, immune system and antioxidant enzyme system can be activated by autologous blood circulation reinfusion, the state of the blood vessel wall is improved, and the physiological function of blood cells is enhanced; the specially selected targeted strain-prebiotic composition can regulate intestinal flora balance, establish an intestinal barrier function, maintain and accelerate metabolism of a human body, decompose blood fat and toxin garbage accumulated in the body, promote detoxification of the intestinal tract, purify the intestinal tract and reduce intestinal toxin substances entering the blood circulation of the human body through a portal system. According to the combination scheme, the blood purification effect can be remarkably improved, the blood fat index is remarkably improved, the purposes of recovering the blood vessel function and enhancing the human immune function are jointly achieved, a new technical scheme and means are provided for prevention and treatment of cardiovascular and cerebrovascular diseases, and wide application prospects are achieved.

The utility model provides a miniature extracorporeal membrane lung oxygenation device which comprises a circulating pump, an oxygenator and a heat preservation device which are respectively arranged on a base, a liquid medium to be tested is filled in the heat preservation device, the liquid medium to be tested is kept at a constant temperature through the heat preservation device, and an outlet end of the heat preservation device is communicated to an inlet end of the oxygenator through a first pipeline. The outlet end of the oxygenator is communicated to the inlet end of the heat preservation device through a second pipeline, a circulating pump is installed on the first pipeline, an oxygen passing hole is formed in the middle of the oxygenator, an air inlet pipe is installed in the oxygen passing hole, and the air inlet pipe is connected to air supply equipment. According to the miniature extracorporeal membrane oxygenation device, blood to be tested is subjected to heat preservation through the heat preservation device, then blood circulation of a human body is simulated in vitro through the circulating pump, important data support is provided for research and development of an ECMO oxygenator, meanwhile, the research and development progress of an ECMO overall sleeve bag can be greatly accelerated, the test cost is reduced, and the test efficiency is improved. The test efficiency is improved.

The invention provides a multi-channel viscoelastic micro-fluidic chip, a manufacturing method and a method for separating MCF-7 cells. The multi-channel viscoelastic micro-fluidic chip comprises a first multi-stage shunting module, a pipette, a second multi-stage shunting module, a single-stage viscoelastic micro-fluidic sub-module and a third multi-stage shunting module, the first multi-stage shunting module is connected with one inlet of the single-stage viscoelastic micro-fluidic sub-module through a pipette; the second multi-stage shunting module is connected with the other inlet of the single-stage viscoelastic micro-fluidic sub-module; and the outlet of the single-stage viscoelastic micro-fluidic sub-module is connected with the third multi-stage shunting module. According to the method, the PEO solution is used as sheath fluid, and the action of elastic force is introduced to cells, so that CTC can be directly separated from undiluted human blood in an ultrahigh-flux manner, and the limitation that erythrocytes need to be split and a blood sample needs to be diluted by dozens of times before cell separation in traditional inertial microfluidics is broken through; and the complexity of operation and the risk of sample pollution are reduced.

The invention provides a biomarker for early Alzheimer's disease detection, a kit, a preparation method and application. The kit mainly contains seven capture antibodies and detection antibodies which can be specifically combined with human blood metabolites, has the characteristics of high detection sensitivity, high specificity and high accuracy, not only can distinguish blood samples of forgetting mild cognitive impairment patients, but also can identify early-stage Alzheimer's disease patients.

The utility model discloses a device for preparing platelet-rich plasma suspension and gel containing blood cells. Comprising a fixing frame, at least one rapid clamping pipe clamp installed on the fixing frame, a vacuum centrifugal pipe clamped in the rapid clamping pipe clamp, and two suction devices capable of being inserted into the centrifugal pipe from the top or the bottom of the centrifugal pipe. The pusher is used for pushing the aspirator to be inserted into the centrifugal tube; the rotating mechanism is used for driving the pusher to rotate so as to enable the aspirator to face the top or the bottom of the centrifugal tube; the utility model solves the problems of blood pollution, manual operation error and low extraction rate in the manual operation process in the prior art, retains all blood platelets and white blood cells in the blood, retains red blood cells in normal proportion and most plasma proteins, and improves the extraction efficiency. Moreover, the concentration of platelets and leukocytes is constantly about 4 times of the concentration of blood of common normal people, the functions of erythrocyte components are reserved, and the functional effects of various components in the blood can be better exerted.

The invention provides a motor control device and method and a ventricular assist device, and relates to the field of medical instrument control. The motor control device comprises a motor working state monitoring module and an abnormity correction module, and the motor working state monitoring module is used for monitoring whether a motor is in an abnormal working state based on a motor working index; the abnormity correction module is used for generating a current impact instruction when the motor is in an abnormal working state; wherein the current impact instruction is used for adjusting the current current of the motor into impact current, and the impact current is greater than the current current. By using the motor control device provided by the embodiment of the invention, the correction of the abnormal working state of the motor can be realized under the conditions that the loss of the motor is relatively small and the influence on a human body is relatively small; the motor control device provided by the embodiment of the invention is used for controlling the motor of the ventricular assist device, so that the loss of the motor can be reduced, and the influence on human blood cells can also be reduced.

The invention provides a calibration method for real-time dynamic blood glucose monitoring. The calibration method comprises the steps that 1, weak current signals generated by a glucose sensitive electrode are obtained regularly; 2, filtering the detected weak current signal by adopting a sliding window double-layer screening algorithm; 3, monitoring the body temperature of the human body, compensating the temperature based on the filtered weak current value, and estimating the glucose concentration after temperature compensation; 4, monitoring the PH value of the human blood, compensating the PH value according to the filtered weak current value, and estimating the glucose concentration after PH value compensation; and 5, combining the glucose concentrations after temperature and pH value compensation, and carrying out filtering processing on the combined glucose concentrations by adopting a parameter compensation filtering algorithm to obtain a final glucose concentration estimation result.

The invention relates to a method for separating out and condensing specific protein in liquid for dyeing and detection. The liquids include but are not limited to human samples, human blood, saliva, urine and the like. The liquid is diluted and its pH is raised or lowered to form a mixed liquid. Placing the mixed solution in an electrostatic field, moving the specific protein in the mixed solution to one side of the mixed solution, accurately dropwise adding an acidic or alkaline solution, adjusting the pH value of the mixed solution, enabling the pH value of the mixed solution to reach the isoelectric point of the specific protein, and enabling the specific protein to be separated out and precipitated on one side of the mixed solution. In addition, according to the sequence of the pH values from large to small or from small to large, the isoelectric points of all the specific proteins can be traversed in the process, and all the specific proteins can be separated out and precipitated in the same area of the mixed solution.

The utility model discloses an intravascular ultrasound catheter and an ultrasound diagnosis system, the intravascular ultrasound catheter comprises a tip end, an imaging tube section and a conveying tube section which are arranged in sequence from the far end to the near end, and the tip end, the imaging tube section and the conveying tube section are internally provided with guide wire cavities for a guide wire to penetrate; core part cavities are formed in the imaging pipe section and the conveying pipe section, transducer core parts are arranged in the core part cavities, and ultrasonic transducers are arranged at the far ends of the transducer core parts; a transition part is arranged at the far end of the conveying pipe section, so that the conveying pipe section can generate local deformation; the guide wire control component allows the guide wire to move in the operating state, inhibits the guide wire from moving in the locking state, and limits the guide wire at the position away from the ultrasonic transducer as a whole. The intravascular ultrasonic catheter can be bent according to the physiological curvature of a human blood vessel, has the capability of easily passing through a tortuous blood vessel, reduces the risk of pressing the blood vessel and peripheral tissues, effectively reduces the influence of signal shielding caused by a guide wire, and realizes full-angle scanning of the ultrasonic catheter.

The invention relates to the technical field of detection, and discloses a detection method and application of p-phenylenediamine antioxidants and quinone derivatives thereof, and the method comprises the following steps: taking a blood sample or a tissue sample, placing in a centrifuge tube, adding a recovery rate indicator solution and a glutathione solution, adding an extraction solvent, extracting twice, and combining the two solutions; centrifuging for 4-6 minutes at the speed of 3000-4500 rpm after each extraction, and combining the two extracts to obtain an extract to be detected; concentrating the to-be-detected extracting solution to be dry under soft nitrogen to obtain a to-be-detected concentrated dry substance; purifying with / without an HLB column; further concentrating the eluent, adding acetonitrile for redissolving, passing through an organic filter membrane, putting into a small sample injection bottle, and concentrating again; adding an internal standard solution to a constant volume to obtain a to-be-detected sample solution; and finally, detecting the sample solution to be detected by using an ultra-high performance liquid chromatography system and a mass spectrometer. According to the invention, the blank of no corresponding detection method for various PPDs and PPD-Qs in human blood and tissues is filled up.

The invention provides a kind of gel material, including the following components: agar, carrageenan, konjac gum, additives; The mass ratio of described agar, carrageenan, konjac gum is 18-22:1-5:1-5; The described additives include potassium dihydrogen phosphate, potassium sorbate, food coloring. The venipuncture model of the present invention is a highly simulated human blood vessel model, which can simulate real human blood vessel structure, so that learners can perform practical operation in a simulated environment, improve learning effect, adopt agar as main material, simple to make, with low cost, convenient for large-scale production and promotion, single model single point can actually enter needle puncture and reach more than 70 times, improve mold service life, and reduce cost.

The invention belongs to the technical field of tumor resistance, and particularly relates to a cabazitaxel albumin composition and application thereof. The cabazitaxel albumin composition comprises cabazitaxel and human serum albumin, and does not contain a surfactant; the solution is a clear solution in a liquid state; the present invention relates to a Cabazitaxel injection for use in the treatment of a cancer patient by infusion administration, the dosage of Cabazitaxel infused to said patient being about 10-40 mg / m2, preferably 20 mg / m2 or 25 mg / m2, optionally in combination with a corticoid, such as prednisone, optionally repeatedly administered to said patient at a new cycle per 3 weeks, having lower adverse effects than originally developed Cabazitaxel injections, and more particularly to a Cabazitaxel injection for use in the treatment of cancer patients. And a higher disease control rate is achieved for patients with advanced solid tumors.

1. Name of the product in this design: Electronic blood pressure monitor (14). 2. Purpose of this design: For measuring human blood pressure. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. The name of this design product: Blood Pressure Monitor (Flip Cover). 2. Application of this product: Suitable for measuring human blood pressure data at home. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present invention provides an artificial heart pump device and a preparation method of a magnetic diaphragm pump, belonging to the field of medical devices. The artificial heart pump device includes a magnetic diaphragm pump system and a magnetic field generating system; the magnetic diaphragm pump includes a magnetic diaphragm and a non-magnetic pump body; after the magnetic diaphragm is magnetized radially, it deforms under a uniform magnetic field; the non-magnetic pump body cooperates with the magnetic diaphragm to generate elastic deformation, and realizes the function of pumping blood by changing the volume of the magnetic diaphragm pump; a hose connects each artery or vein where the magnetic diaphragm pump is connected to the human heart to complete the transportation and circulation of blood in the human blood vessels and the magnetic diaphragm pump; a one-way valve controls the one-way flow of blood; the magnetic field generating system generates a uniform magnetic field along the axial direction of the magnetic diaphragm. The artificial heart pump device provided by the present invention has higher operation reliability and longer service life.

The application discloses an albumin nano-drug based on HSP90 inhibitor and a preparation method and application thereof, and belongs to the technical field of medicines.The short peptide A6 is modified to human blood albumin through a connecting chain, and the human blood albumin modified by the A6 is self-assembled with geldanamycin derivative G2111 in the presence of an organic solvent, so that the G2111 is combined to the hydrophobic region of the human blood albumin through a non-covalent bond, effective loading of the G2111 is realized, the solubility of the geldanamycin derivative is improved, the drug is targetedly released into cancer cells with high expression of CD44, the targeted accumulation of the drug in tumor tissues is enhanced, damage to other normal tissues and cells caused by off-target effects of the drug is avoided, the albumin nano-drug can be simultaneously used for chemotherapy of leukemia and solid tumors, and has important practical significance.

The invention relates to the technical field of drug detection, in particular to a molecularly imprinted sensor for quantitatively detecting olanzapine in human blood as well as a preparation method and application of the molecularly imprinted sensor. Au-Pt NSF is deposited on the surface of a substrate electrode through an HBDT method, then a molecularly imprinted polyaniline layer is prepared through electro-polymerization, and the molecularly imprinted sensor is formed. A classical redox probe potassium hexacyanoferrate is used as a tool, and DPV is used for monitoring current change (delta I) caused by olanzapine addition, so that sensitive quantitative detection of olanzapine is realized. The sensor prepared by the invention shows a good linear relationship to olanzapine in the concentration ranges of 0.005-0.4 mu M and 0.4-10 mu M, the detection limit is 0.94 nM, and the sensor has high reproducibility and stability (relative standard deviation RSDlt;

The present invention discloses a magnetocardiogram intervention probe and a magnetocardiogram measurement system. The magnetocardiogram intervention probe includes: a probe body, a catheter, a microwave waveguide, and a radiation structure. The catheter is connected to the probe body. The microwave waveguide is embedded in the catheter and extends along the length direction of the catheter. One end of the microwave waveguide is connected to a microwave system. The radiation structure is arranged in the probe body and is used to emit the microwave transmitted by the microwave waveguide in all directions. According to the magnetocardiogram intervention probe of the present invention, by connecting the catheter to the probe body, embedding the microwave waveguide in the catheter and extending it along the length direction of the catheter, connecting one end of the microwave catheter to the microwave system, and arranging the radiation structure in the probe body, the microwave transmitted by the microwave waveguide is diffused in all directions through the radiation structure, so that the magnetocardiogram intervention probe can emit microwaves after entering the human blood vessel. At the same time, the magnetocardiogram intervention probe also eliminates the coil, thereby reducing the volume of the intervention probe and improving the measurement range of the magnetocardiogram measurement system.

According to the pulsating anti-load pants and the simplified air bag heart assisting device, by adding the anti-load clothes and the pulsating and blood pumping functions of the anti-load pants, the standing anti-load pants during cruising are changed into pulsating pressurizing pants with time control air valve pulsating type inflation and deflation or left and right air bags alternately inflated and deflated; the thick and long blood vessels of the lower limbs and the one-way valves on the inner walls of the thick and long blood vessels of the lower limbs are extruded to pump blood to become a second external heart; a simplified air bag heart assisting device is a pulsating anti-load pants reduced configuration scheme, outer-layer clothes and pants of anti-load pants are removed, and the simplified air bag heart assisting device is simplified into a crus air bag or a thigh and crus communicated air bag sewed nylon fastener tape device, and left and right leg air bag air conveying rubber pipes are connected with two electromagnetic three-way valves respectively and then are combined through rubber pipes to be connected with an air pump. Two-way power-on and power-off of a time relay are used for controlling left and right electromagnetic valves or improved valves to be connected with air bags, an air pump and an external tee joint, so that left and right leg air bags are inflated and deflated in turn; the invention can be used as heart-aiding anti-load trousers and heart-aiding fitness equipment, and can improve the blood circulation of the human body.

FIELD: pharmacology.SUBSTANCE invention can be used to determine the concentration of an anti-tuberculosis drug in blood serum. The method for determining the concentration of bedaquiline in the blood serum in patients with tuberculosis or mycobacteriosis is that whole blood samples are centrifuged at 3000 rpm for 20 minutes, then the blood plasma is collected in sterile 1.5 mL Eppendorf tubes, then 900 mcL of acetonitrile are added to 300 mcL of plasma and centrifuged at 13500g for 15 minutes, then 1 mL of the supernatant is transferred to a chromatographic vial and make the assay by UHPLC MS / MS using an Athena UHPLC C18, 1.8 mcM, 120A, 2.1×100 mm chromatography column, when using an aqueous solution containing 5 g / L of ammonium acetate, 25 ml / L of concentrated acetic acid, 2 ml / L trifluoroacetic acid as mobile phase A and 100% acetonitrile as mobile phase B, the concentration of bedaquiline is determined using a pre-plotted calibration curve.EFFECT: determination of bedaquiline in human blood plasma in a time not exceeding 6 minutes.1 cl, 9 dwg, 6 tbl

The invention relates to a method for avoiding a human body pre-stored anti-PEG antibody and application of a terminal hydroxyl group-containing PEGylated nano-carrier in preparation of a medicine for avoiding the human body pre-stored anti-PEG antibody. The composition contains a terminal hydroxyl group-containing PEGylated nano-carrier and a nano-preparation. The terminal hydroxyl group-containing PEGylated nano-carrier and the nano-preparation are low in combination with the anti-PEG antibody pre-stored in the human body, so that the anti-PEG antibody can be prevented from being quickly cleared in the blood of the human body, and the treatment effect can be better exerted. Besides, the PEGylated nano-carrier containing terminal hydroxyl and the nano-preparation can relieve complement activation by avoiding combination with a pre-stored anti-PEG antibody in human blood, so that side effects such as clinical injection reaction and the like are relieved.

The invention relates to the technical field of medical instrument detection, and particularly provides a portable glucometer calibration device and a detection method. The device is designed based on an adjustable microampere-level constant current source circuit, a chemical reaction between human body blood sugar and portable glucometer test paper is simulated to generate a micro-current signal, and the micro-current signal and a to-be-tested glucometer form a current loop through an interface of the calibration device. Wherein a micro-current signal output by the constant current source keeps a linear corresponding relation with the blood glucose concentration value and can be used as a preset standard value. By comparing the deviation between the preset standard value of the calibration device and the measured value of the glucometer, the measurement error of the measured instrument can be calculated. Compared with a traditional calibration mode, the device adopts a constant current control technology of an operational amplifier framework, accurate mapping of microampere-level current and blood glucose concentration is achieved, and the blood glucose meter device can be effectively calibrated by comparing the actually measured blood glucose concentration of the blood glucose meter to be detected with the standard blood glucose concentration set by the detection device. The product can provide a convenient glucometer calibration device for medical institutions and individual users.

1. The name of the design product: human blood sample analysis report graphical user interface for electronic equipment. 2. The use of the design product: for an electronic device. 3. The design points of the design product: in the graphical user interface. 4. The picture or photo that best indicates the design points: front view. 5. Other views are conventional designs, and other views are omitted. 6. The use of the graphical user interface: the interface is used for human blood sample data processing and disease diagnosis analysis. The front view is the initial interface. Interface change state diagram 1 is the interface presented after clicking the " " button in the upper right corner of the front view. Interface change state diagram 2 is the interface presented after clicking the "WBC Message" module in interface change state diagram 1 to display hidden information. Interface change state diagram 3 is the interface presented after clicking the "WBC" histogram in interface change state diagram 2. Interface change state diagram 4 is the interface presented after clicking the "RBC" histogram in interface change state diagram 3. 7. Other circumstances that need to be explained: the chart parameters in the design pictures and photos are used to reflect the interface effect. The chart parameters in the interface can change according to the actual use of the interface and the data reception.

The application belongs to the technical field of biotechnology, and discloses a nano antibody targeting B cell BCMA and application thereof. The amino acid sequences of the complementarity determining regions CDR1-CDR3 of the nano antibody are selected from SEQ ID NO. 1-12. The nano antibody provided by the application can specifically bind to B cells in human blood, especially activated plasma cells, so as to eliminate B cells producing pathological antibodies. Compared with traditional antibodies, the nano antibody provided by the application has a smaller molecular weight, high stability, low cost, easy expression and high expression amount, and is suitable for large-scale production. The nano antibody is combined with a solid-phase carrier in the application, so that B cells in blood can be targeted and eliminated, the number of B cells in blood of patients can be reduced in a short time, and the antibody level can be reduced, thereby improving the quality of life, reducing complications, and providing a new treatment option for patients who are ineffective or intolerant to traditional treatment.