140 results about "Human blood" patented technology

The invention discloses a method for constructing a health influence prediction model based on multi-source air data coupling, and relates to the technical field of air quality health monitoring, and the method comprises the steps: obtaining multi-source air environment data in a selected space as an environment index, and obtaining a multi-source physiological signal of a person in the selected space as a physiological index; on the basis of the feature vectors of the environment indexes and the physiological indexes, the coupling relation between the air environment features and the physiological features is constructed, modeling is conducted on the nonlinear coupling relation between the air features and the physiological features through a time sequence deep learning model, and the action rule of air pollution accumulative exposure on dynamic changes of the physiological indexes is captured. Through feature extraction and cross-modal coupling, the comprehensive influence rule of air pollution on the blood pressure, blood oxygen, body temperature, heart rate, heart rate variability and blood glucose physiological indexes of the human body can be revealed, and dynamic prediction of health risks can be achieved through a deep learning model.

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

The application discloses an albumin nano-drug based on HSP90 inhibitor and a preparation method and application thereof, and belongs to the technical field of medicines.The short peptide A6 is modified to human blood albumin through a connecting chain, and the human blood albumin modified by the A6 is self-assembled with geldanamycin derivative G2111 in the presence of an organic solvent, so that the G2111 is combined to the hydrophobic region of the human blood albumin through a non-covalent bond, effective loading of the G2111 is realized, the solubility of the geldanamycin derivative is improved, the drug is targetedly released into cancer cells with high expression of CD44, the targeted accumulation of the drug in tumor tissues is enhanced, damage to other normal tissues and cells caused by off-target effects of the drug is avoided, the albumin nano-drug can be simultaneously used for chemotherapy of leukemia and solid tumors, and has important practical significance.

The invention relates to the technical field of drug detection, in particular to a molecularly imprinted sensor for quantitatively detecting olanzapine in human blood as well as a preparation method and application of the molecularly imprinted sensor. Au-Pt NSF is deposited on the surface of a substrate electrode through an HBDT method, then a molecularly imprinted polyaniline layer is prepared through electro-polymerization, and the molecularly imprinted sensor is formed. A classical redox probe potassium hexacyanoferrate is used as a tool, and DPV is used for monitoring current change (delta I) caused by olanzapine addition, so that sensitive quantitative detection of olanzapine is realized. The sensor prepared by the invention shows a good linear relationship to olanzapine in the concentration ranges of 0.005-0.4 mu M and 0.4-10 mu M, the detection limit is 0.94 nM, and the sensor has high reproducibility and stability (relative standard deviation RSDlt;

According to the pulsating anti-load pants and the simplified air bag heart assisting device, by adding the anti-load clothes and the pulsating and blood pumping functions of the anti-load pants, the standing anti-load pants during cruising are changed into pulsating pressurizing pants with time control air valve pulsating type inflation and deflation or left and right air bags alternately inflated and deflated; the thick and long blood vessels of the lower limbs and the one-way valves on the inner walls of the thick and long blood vessels of the lower limbs are extruded to pump blood to become a second external heart; a simplified air bag heart assisting device is a pulsating anti-load pants reduced configuration scheme, outer-layer clothes and pants of anti-load pants are removed, and the simplified air bag heart assisting device is simplified into a crus air bag or a thigh and crus communicated air bag sewed nylon fastener tape device, and left and right leg air bag air conveying rubber pipes are connected with two electromagnetic three-way valves respectively and then are combined through rubber pipes to be connected with an air pump. Two-way power-on and power-off of a time relay are used for controlling left and right electromagnetic valves or improved valves to be connected with air bags, an air pump and an external tee joint, so that left and right leg air bags are inflated and deflated in turn; the invention can be used as heart-aiding anti-load trousers and heart-aiding fitness equipment, and can improve the blood circulation of the human body.

FIELD: pharmacology.SUBSTANCE invention can be used to determine the concentration of an anti-tuberculosis drug in blood serum. The method for determining the concentration of bedaquiline in the blood serum in patients with tuberculosis or mycobacteriosis is that whole blood samples are centrifuged at 3000 rpm for 20 minutes, then the blood plasma is collected in sterile 1.5 mL Eppendorf tubes, then 900 mcL of acetonitrile are added to 300 mcL of plasma and centrifuged at 13500g for 15 minutes, then 1 mL of the supernatant is transferred to a chromatographic vial and make the assay by UHPLC MS / MS using an Athena UHPLC C18, 1.8 mcM, 120A, 2.1×100 mm chromatography column, when using an aqueous solution containing 5 g / L of ammonium acetate, 25 ml / L of concentrated acetic acid, 2 ml / L trifluoroacetic acid as mobile phase A and 100% acetonitrile as mobile phase B, the concentration of bedaquiline is determined using a pre-plotted calibration curve.EFFECT: determination of bedaquiline in human blood plasma in a time not exceeding 6 minutes.1 cl, 9 dwg, 6 tbl

The utility model relates to a simple and easy device for detecting human blood type, including flushing liquid containing container, detection subassembly and liquid suction piece, flushing liquid containing container has the containing cavity that contains flushing liquid, and containing cavity has top opening to allow detection subassembly inserts containing cavity, and containing cavity inboard wall is provided with first limit piece, the antibody for blood type detection is fixed in detection subassembly, the antibody can be combined with blood type antigen specificity, detection subassembly has first end and second end, liquid suction piece detachably fixed in second end of detection subassembly, detection subassembly outside wall is provided with second limit piece, wherein, when first end of detection subassembly inserts containing cavity, first limit piece and second limit piece cooperate and form longitudinal limit to fix detection subassembly in containing cavity, the utility model has the characteristics of simple operation, high accuracy, fast detection.

The invention relates to a method for determining the blood alcohol content (BAC) of a person in a vehicle (1), comprising the following steps: acquiring one or more images of the person in the vehicle (1) by means of one or more imaging units (2) arranged on the vehicle; the images are analyzed through a data processing unit (3), and human body data and face data of the person are determined through a database (5); calculating three-dimensional target vectors V1 and / or V2 of the mouth and / or nose of the person relative to an alcohol air detector (4) arranged in the vehicle (1) according to the facial data, in particular an infrared laser spectrometer for directional non-contact detection; the alcohol air detector (4) is started, and the expiratory alcohol concentration (BRAC) of the mouth and nose area of the person is measured in combination with the target vector V1 and / or V2; calculating a correction coefficient K in combination with human body data (especially gender, weight, age and / or height) of the person; and determining the blood alcohol content through a formula BAC = K * BRAC.

1. Name of the product in this design: Balloon Catheter (1). 2. Application of this design: It can be used for the dilation and treatment of human blood vessels or non-vascular cavities. 3. The key design feature of this product is its shape. 4. Images or photos that best illustrate the design key points: usage status reference diagrams.

1. The name of the design product: the measurement graphical user interface of sphygmomanometer. 2. The use of the design product: for measuring blood pressure. 3. The design points of the design product: the display content of the display panel. 4. The picture or photo that best shows the design points: top view. 5. The use of the graphical user interface: for the measurement interaction of sphygmomanometer. 6. The human-computer interaction mode of the graphical user interface: the interface of the top view shows the content displayed by the sphygmomanometer during the detection of human blood pressure, taking the example of the interface of the quantitative change of blood pressure value to "27mmHg"; during the detection of human blood pressure, the interface of the top view changes to the content displayed by the interfaces of change state diagram 1, change state diagram 2, and change state diagram 3 respectively with the change of blood pressure value; when the detection is completed, taking the example of the highest blood pressure value of 137mmHg, the lowest blood pressure value of 76mmHg, and the heart rate of 72, the interface jumps to change state diagram 4. 7. Other circumstances that need to be explained: the measurement graphical user interface of sphygmomanometer in the design picture requests protection, and the dashed line part does not belong to the content of the design to be protected.

The present application relates to the technical field of artificial implant medical device surface modification and middle ear hearing reconstruction, and discloses a processing method for enhancing the fixing stability of an artificial auditory ossicle prosthesis, the prosthesis and application. The method comprises the following steps: after the surface of the auditory ossicle prosthesis in contact with the middle ear tissue is cleaned, a polydopamine layer is formed in a basic dopamine solution, then gelatin, hyaluronic acid or cellulose sulfate is connected to the surface of the polydopamine layer through a carbodiimide activation system to form a viscous functional layer, and the dry sponge-like structure is obtained through freeze-drying. The functional layer can quickly rehydrate and restore the adhesion state after contacting with human blood or tissue fluid, thereby improving the fixing stability of the artificial auditory ossicle prosthesis in the initial implantation stage and reducing the risk of displacement or dislocation.

This invention relates to the field of electrochemical detection technology for vitamin E, specifically to an electrochemical detection device and method for vitamin E. The method includes: utilizing a detection system composed of a glassy carbon electrode, a saturated calomel electrode, and a platinum wire electrode; performing a series of optimizations and screenings to determine the SWV electrochemical detection method; and electrode pretreatment: using 0.05 μm alumina powder to perform circular polishing on the glassy carbon electrode in both directions for 3-4 minutes, followed by ultrasonic cleaning with anhydrous ethanol and pure water for three minutes each time. Finally, the electrode is scanned using the SWV method in a prepared buffer solution until it stabilizes. The beneficial effects are: this invention is convenient and simple to operate, has a simple formulation that greatly optimizes the detectable limit, has low manufacturing cost and is readily available, and requires no electrode modification; the lowest detectable concentration is far below the minimum normal range of vitamin E in human blood.

The utility model relates to the field of hemodialysis especially relates to hemodialysis pipeline anti -coagulation oscillator structure, including bottom plate, the lower end of bottom plate is integrated with the built -in self -locking mechanism's universal wheel, the upper end fixed connection of bottom plate has vertical vibration unit, installs the support plate in vertical vibration unit, the lower end of support plate is configured vibration motor as drive source to carry out vertical direction's vibration action, the upper end of support plate sets up horizontal reciprocating motion module, and is provided with the receiving plate in horizontal reciprocating motion module, still fixed with the vertical board on the support plate, the surface of vertical board is provided with linkage's sliding mechanism, and sliding mechanism and horizontal reciprocating motion module synergistic effect are used for realizing the guiding displacement of receiving plate, the utility model discloses through vertical vibration and horizontal reciprocating motion combination, more effectively simulate human blood circulation, reduce blood coagulation risk, at the same time, the lower end of bottom plate is integrated with self -locking universal wheel, makes oscillator mobile flexible and fixed stable, and it is convenient to use in different scenes.

The invention relates to a construction method of a peripheral red blood cell humanized mouse, which comprises the following steps: transplanting human hematopoietic stem cells into the mouse and then applying a red blood cell inducer to the mouse, or applying a red blood cell inducer to the mouse and then infusing human red blood cells into the mouse. The red blood cell inducer comprises an antibody targeting mouse macrophage, dexamethasone or a derivative thereof, and a human macrophage colony stimulating factor. In a mouse transplanted with human hematopoietic stem cells, one or more of an antibody targeting mouse macrophages, dexamethasone and a human macrophage colony stimulating factor can be used in the red blood cell induced maturation process, and high-level human red blood cell reconstruction can be quickly realized within three weeks; the maturity and the denucleation ratio of peripheral human erythrocytes reconstructed in the mouse are completely consistent with those of normal human blood; in a mouse transplanted with human erythrocytes, the erythrocyte induction process can be single treatment of an antibody or dexamethasone, or combined use of the antibody and dexamethasone. The invention also provides application of the peripheral erythrocyte humanized mouse.

1. The name of the design product: blood oxygen meter. 2. The use of the design product: for monitoring the oxygen content in human blood. 3. The design points of the design product: the shape of design 1, the combination of shape and color of design 2. 4. The picture or photo that best indicates the design points: the perspective view of design 1. 5. Design 1 is designated as the basic design. 6. Other circumstances that need to be explained: design 2 of the design to be protected contains color.

1. Name of the product in this design: Blood Glucose Analyzer. 2. Purpose of this design: A medical device for measuring the concentration of glucose in human blood. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The invention provides an intermittent body fluid parameter detection method and device and a related system, and belongs to the technical field of human body blood oxygen detection.The intermittent body fluid parameter detection method comprises the steps that an intermittent body fluid monitoring instruction is obtained, a monitoring mode is determined according to the intermittent body fluid monitoring instruction, and then a first control instruction for a reagent bag is determined according to a reagent calibration mode; controlling a peristaltic pump and a fluid selector according to the first control instruction to obtain a first compensation parameter of the test card; controlling the automatic collection device to collect target body fluid of the target user, conveying the target body fluid to the first pipeline through the sampling interface, determining a second control instruction aiming at the reagent bag according to the body fluid detection mode, and controlling the peristaltic pump and the fluid selector to suck the target body fluid to generate a first body fluid detection parameter according to the second control instruction; and performing calculation according to the first compensation parameter and the first body fluid detection parameter to obtain a target body fluid detection parameter of the target user. The accuracy of body fluid parameter detection can be improved.

1. Name of the product in this design: Pulse Oximeter. 2. Purpose of this design: This design is used to detect human blood oxygen and pulse. 3. The key design points of this product are: the shape of the product shown in 1 and 2, and the combination of shape and color of the product shown in 3 and 4. 4. The image or photograph that best illustrates the key design points: Design 1 3D view. 5. The design for which protection is sought includes color. 6. Design 1 is designated as the basic design.

The application discloses a multifunctional artificial organ device, which comprises a shell, a blood pipe bundle and a hydrogel, the blood pipe bundle is contained in a containing cavity, the blood pipe bundle is communicated with a blood inlet and a blood outlet, the hydrogel is filled in the containing cavity, the hydrogel comprises a gel layer and allogeneic therapeutic cells, the allogeneic therapeutic cells are wrapped in the inside of the gel layer, and the allogeneic therapeutic cells absorb nutrient substances and oxygen separated from the blood pipe bundle and secrete therapeutic factors to the blood pipe bundle. The multifunctional artificial organ device in the embodiment of the application wraps the allogeneic therapeutic cells in the inside of the gel layer, so that the immune rejection of the human body is reduced, the human blood is filtered through the blood pipe bundle, the nutrient substances and oxygen are separated from the blood pipe bundle for normal metabolism of the allogeneic therapeutic cells, the allogeneic therapeutic cells generate therapeutic factors, the therapeutic factors flow to internal organs along with the blood, and the purpose of disease treatment is achieved.

This invention discloses a vascular organ-on-a-chip that simulates human blood pressure, comprising a substrate, a channel layer, a cell dynamic culture module, a solution mixing module, and a cell mechanical property measurement module. The cell dynamic culture module includes a first culture channel and a second culture channel, with a serpentine channel connecting the upstream of the first culture channel and the upstream of the second culture channel. The solution mixing module includes two oppositely arranged solution mixing channels, which are respectively connected to the first culture channel and the second culture channel. The cell mechanical property measurement module includes multiple measurement channels arranged side-by-side, with one end of each measurement channel connected to the other end of one solution mixing channel and the other end connected to the other end of another solution mixing channel. This invention simulates the human blood pressure environment within the vascular organ-on-a-chip, enabling simultaneous cell culture under parallel gradient pressure within the chip, and combining the vascular organ-on-a-chip with cell mechanical property measurement.

The anti-cancer use of a camptothecin derivative which demonstrates a surprising resistance to the degrading effects of Human Serum Albumin ("HSA") in vivo is disclosed. Since HSA represents about half of serum protein in human blood, previous camptothecins generally worked poorly or not at all in vivo due to inactivation by HSA among other factors. Since NSS-01 is similar in mechanism of action to other camptothecins, and as demonstrated herein has both: (i) greater anti-tumor activity against various human cancers and (ii) less toxicity at therapeutic dosing - than topotecan and irinotecan; and without wishing to be bound by theory, NSS-01 demonstrated desirable antitumor activity against adenocarcinomas, it therefore should demonstrate desirable antitumor activity against other cancers that are susceptible to Topoisomerase I inhibitors.

This invention relates to an electronic mercury sphygmomanometer, comprising a folding housing, an upper housing, a lower housing, a measurement display module, and a measurement control module. The folding housing is located on the upper part of the lower housing and is rotatable. The lower housing is an open rectangular box, and the folding housing is folded into this rectangular box when not in use. The upper housing is a cover plate located at the opening of the lower housing. The measurement display module is located on the folding housing, and the measurement control module is located inside the lower housing. The measurement display module is connected to the measurement control module, and its operation is controlled by the measurement control module. This invention enables automatic measurement and automatic reporting of measurement values. It can measure blood pressure, heart rate, and pulse strength, and can accurately measure human blood pressure even with long-term use. It can be widely used in the medical and health field.

The application provides a kind of gamma delta T cell preparation and its preparation method and application, it is related to the field of biotechnology.The composition provided by the application includes: coenzyme Q10, vitamin C, human blood albumin, trehalose, sodium pyruvate and amifostine.Using the composition and related preparation provided by the application can effectively improve the killing ability of gamma delta T cells and maintain the function of gamma delta T cells, and can effectively inhibit tumor growth.

An immunological analysis mode of a novel total antibody assay and a kit for detecting antibodies of infectious diseases in human blood samples according to the mode, the kit comprising: a first reagent containing at least one antigen coated on a solid support and an anti-human IgM antibody coated on a solid support; and a second reagent containing at least one labeled antigen and a labeled anti-human IgG antibody; wherein at least one antigen of the at least one antigen coated on the solid support and at least one antigen of the at least one labeled antigen can bind to the same IgG antibody or the same IgM antibody in the sample. The kit can overcome the disadvantages caused by the detection principle while retaining the advantages of each detection principle. In addition, a method for detecting antibodies produced after pathogen infection in a sample is provided.

The invention provides a UWB-based non-contact blood pressure detection method and system. UWB impulse pulse signals are transmitted through double transmitting antennas in a time division duplex mode, echo signals reflected by a to-be-detected part of a human body are synchronously collected through four receiving antennas, and four synchronous baseband I / Q signals are output; performing channel consistency calibration, direct current removal, static clutter suppression and differential motion compensation processing on the four paths of synchronous baseband I / Q signals to obtain pre-processed multi-channel echo signals; performing spatial spectrum estimation on the preprocessed multi-channel echo signals to position a blood vessel area to be measured, extracting a continuous phase change sequence through multi-channel joint phase unwrapping, converting the continuous phase change sequence into sub-millimeter micro-displacement pulse wave time sequence signals corresponding to human body blood vessel pulsation, and extracting multi-channel pulse wave spatial characteristic parameters; on the basis of a pre-calibrated multi-channel feature-blood pressure mapping model, calculating systolic pressure and diastolic pressure values of the human body according to the multi-channel pulse wave spatial feature parameters; outputting and storing the blood pressure detection result.

This invention belongs to the field of biomedical technology, specifically relating to a recombinant human plasminogen mutant, its preparation method, and its application. A recombinant human plasminogen mutant, the amino acid sequence of which is shown in SEQ ID NO.3. The recombinant human plasminogen mutant of this invention, compared to wild-type mPLG, can be directly expressed solublely in the supernatant of *E. coli* fermentation broth. Soluble expression allows for direct chromatography of the fermentation broth to obtain the target protein, which has significant advantages over inclusion body renaturation treatment in terms of process simplification, activity loss, time cost, and production cost. Furthermore, the activity of the mutant protein was tested using the fibrin plate method and kit method. The results showed that the titer of the target protein was approximately 8 UI / mg, which is similar to the titer of mPLG obtained by renaturation before mutation and PLG obtained from human blood. In summary, compared to the wild type, the mutant strain exhibits significantly improved solubility while maintaining high protein activity.

1. Name of the product in this design: Wrist Blood Pressure Monitor (A10). 2. Purpose of this design: For measuring human blood pressure. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The invention provides a separation and purification method and application of intravenous injection immunoglobulin, and the separation and purification method comprises the following steps: (1) separating from healthy human blood to obtain components II and III, and then filtering to obtain a loading solution; (2) carrying out anion column chromatography on the loading liquid obtained in the step (1), and collecting to obtain flow-through liquid and leacheate; and (3) carrying out cation column chromatography on the flow-through liquid and the leacheate obtained in the step (2) to obtain the intravenous injection immune globulin, namely completing separation and purification of the intravenous injection immune globulin. According to the method provided by the invention, only two-step chromatographic purification is needed, so that the requirements that the purity of the IVIG monomer and the dimer is higher than 99%, the purity of the IVIG monomer is higher than 95% and the total yield can reach 80% in the obtained IVIG can be met, precious plasma resources are fully utilized, the operation is simple, and the method can be used for large-scale production.

The present application relates to the technical field of biology, and discloses a cell preservation solution, a preparation method and preparation thereof, and a cell preservation method. The cell preservation solution contains 1-10 mL compound electrolyte glucose injection, 1-10 mL human blood albumin injection, 1-10 mL compound amino acid injection, 10-20 uM salvianolic acid B, 20-60 uM rhodioside, and 1-10 uM ginkgo biloba bilobal, and the compound electrolyte injection is supplemented. The cell preservation solution can improve the biological activity of cells and prolong the preservation time of cells in multiple ways by adding traditional Chinese medicine extracts as antioxidants, membrane stabilizers and antithrombotics in response to the excess of free radicals in the low-temperature preservation process.

This invention provides a method for the continuous preparation of paclitaxel albumin nanoparticles, comprising the following steps: A) Paclitaxel raw material is fed into an emulsification device at a first rate of 80-90 ml / min; albumin aqueous solution is fed into the emulsification device at a second rate of 3-4 L / min; B) Paclitaxel raw material and albumin aqueous solution are emulsified and sheared to complete drug loading, thus obtaining the nanoparticles. In this method, the paclitaxel organic solvent and human serum albumin aqueous solution are continuously introduced, allowing for continuous emulsification and shearing. The emulsification and shearing effect is consistent every minute, and the production batch size is only related to time. The batch size is determined by controlling the emulsification and shearing time, and the product uniformity is not affected by the batch size. This invention solves the problem that current paclitaxel nanoparticle preparation processes cannot achieve continuous manufacturing, improving system flexibility; and addresses the problems of batch dependence on equipment and difficulty in batch expansion.