1545 results about "Uric acid" patented technology

Microneedle devices are provided for controlled sampling of biological fluids in a minimally-invasive, painless, and convenient manner. The microneedle devices permit in vivo sensing or withdrawal of biological fluids from the body, particularly from or through the skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The microneedle device includes one or more microneedles, preferably in a three-dimensional array, a substrate to which the microneedles are connected, and at least one collection chamber and / or sensor in communication with the microneedles. Preferred embodiments further include a means for inducing biological fluid to be drawn through the microneedles and into the collection chamber for analysis. In a preferred embodiment, this induction is accomplished by use of a pressure gradient, which can be created for example by selectively increasing the interior volume of the collection chamber, which includes an elastic or movable portion engaged to a rigid base. Preferred biological fluids for withdrawal and / or sensing include blood, lymph, interstitial fluid, and intracellular fluid. Examples of analytes in the biological fluid to be measured include glucose, cholesterol, bilirubin, creatine, metabolic enzymes, hemoglobin, heparin, clotting factors, uric acid, carcinoembryonic antigen or other tumor antigens, reproductive hormones, oxygen, pH, alcohol, tobacco metabolites, and illegal drugs.

The invention discloses an axially chiral R-enantiomer and an axially chiral S-enantiomer of the drug Lesinurad. The axially chiral R-enantiomer shows excellent URAT1 inhibition effect, overcomes the problems that a high dosage of Lesinurad racemate leads to renal toxicity and a low dosage Lesinurad racemate cannot produce additional drug effect, and can be applied to treatment or prevention of symptoms of abnormal tissue uric acid levels.

The invention provides a lactobacillus casei strain and a probiotic composition for lowering blood uric acid and application thereof, and belongs to the technical field of food medicines. The lactobacillus casei strain ZM15 for lowering the blood uric acid has the collection number of CGMCC No.13980. The lactobacillus casei strain ZM15 has the rates of degrading adenylic acid, guanylic acid, adenosine and guanosine as high as 100%; a degraded product does not contain uric acid and allantoin; in addition, the degraded product has a low purine base proportion of only 0.10%, so that the product can be prevented from being further decomposed into the uric acid, and the human blood uric acid content can be effectively reduced. The probiotic composition provided by the invention is obtained by compounding four strains of ZM15, ZM18, ZM122 and ZM05; through mutual coordination of the four strains, the blood uric acid lowering effect of the probiotic composition is significantly better than that during independent application of ZM15, ZM18, ZM122 and ZM05 strains, so that the blood uric acid lowering effect can be further improved.

(Aza)indolizine derivatives represented by Formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, salts thereof or the like. In Formula (I), 0 to 2 of X1, X2, X3 and X4 are a nitrogen atom and the others are CR1; one of T1 and T2 represents cyano and the other represents a group represented by Formula (A), with the proviso that when T1 is cyano, at least one of X1 to X4 is a nitrogen atom; R1 independently represents a hydrogen atom, a halogen atom, a hydroxy group, C1-6 alkyl, C1-6 alkoxy or the like; ring U represents a benzene ring or the like; m represents integral number from 0 to 2; R2 independently represents a fluorine atom, a hydroxy group or the like.

The invention relates to a high bioavailability febuxostat oral solid dosage and a preparation method thereof. The invention is characterized in that the solid dosage comprises: a) febuxostat is C, H, I or J crystal form; b) the average grain diameter of the febuxostat crystal form ranges from 3.5-10mum, preferably 3.5-7mum. The preferable oral solid dosage is tablet, has the advantages of simple preparation technique, low cost and relatively high bioavailability, and can be used for treating diseases relative to extremely-high uric acid, such as gout, and reducing uric acid in blood.

The invention discloses a compound chicory series product and a preparation method thereof. The series product is prepared from main component chicory and one or more yam rhizome, semen coicis, rhizoma smilacis glabrae, Siegesbeckia herb, longhairy antenoron herb, cutch, mulberry leaf, kudzu-vine root, barbary wolfberry fruit, poria cocos, corn stigma, guava leaf, red yeast rice, cassia seed, hawthorn, lotus leaf, aloe and nano selenium according to different applications of the product. The product has the main characteristics of synchronous adjusting effect on endocrine disorder and obvious effects on adjustment of blood uric acid, blood sugar and blood fat and immunity reinforcement, wide adaptive crowd and positive economic and social significance and is easy to realize industrialized large production.

Methods and preparations for treating disorders of the eye and / or causing posterior vitreous disconnection or disinsertion. Preparations containing a) urea, b) urea derivatives (e.g., hydroxyurea, thiourea), c) a non-steroidal anti-inflamatory agents, d) antmetabolites, e) urea, urea derivatives, non-enzymatic proteins, nucleosides, nucleotides and their derivatives (e.g., adenine, adenosine, cytosine, cytadine, guanine, guanitadine, guanidinium, thymidine, thimitadine, uradine, uracil, cystine), uric acid, calcium acetal salicylate, ammonium sulfate or other compound capable of causing non-enzymatic dissolution of the hyaloid membrane or e) any of the possible combinations thereof, are administered to the eye in therapeutically effective amounts.

An apparatus uses carbon nanotubes for electrochemical analysis of biological molecules of interest such as Uric Acid, illustrating how the voltammetric behaviors of uric acid (UA) and L-ascorbic acid (L-AA) at a well-aligned, carbon nanotube, electrode may be used in a biochemical assay. Compared to glassy carbon, a carbon nanotube electrode reduces troublesome overpotentials. Based on its differential catalytic function toward the oxidation of UA and L-AA, the carbon nanotube electrode can be used for a selective determination of UA in the presence of L-AA. The peak current obtained from DPV was linearly dependent on the UA concentration in the range of 0.2 μM to 80 μM with a correlation coefficient of 0.997. The detection limit (3δ) for UA was found to be 0.1 μM. The device allows for detection of UA in a human urine sample, even in the presence of high concentrations of L-AA, using only simple dilution.

The invention discloses a water soluble phenolic acid extract which is obtained by extracting from a medical plant of a clerodendranthus spicatus by the chemical method. The pharmacological experiment testifies that the extract has strong physiological activity and especially has strong physiological activity of resisting the generation of uric acid, and the extract is used for remedying the pain-louse and has good effect of the treatment towards the urinary tract infection or the urinary tract concretion and has little toxic and side effect.

A tea substitute bag capable of lowering the uric acid mainly comprises corn stigma, coix seeds, kudzuvine roots, peach seed kernels, lotus leaves, psyllium, smilax glabra roxb, celery seeds, lophatherum gracile, clerodendranthus spicatus, anoectochilus roxburghii, and fresh lalang grass rhizomes as the basic raw materials. The tea substitute bag is formulated and prepared according to theories of traditional Chinese medicine. The tea substitute can clear away the heat evil and reduce the dampness, activate the channels and alleviate the pain, remove the phlegm and dispel the stasis, adjust and replenish the liver and the kidney, reduce the uric acid, and obviously lighten the pain in acute attack, without any toxic or side effects or pain.

The invention discloses a preparation method of citrate modified NaYF4:Yb,Er / Mn up-conversion luminescent nano material, a hydrogen peroxide or uric acid detection method and applications. The preparation method comprises the following steps: 1) stirring alkali, water, oleic acid, C1-C3 alcohol, a manganese source, a ytterbium source a yttrium source, an erbium source and NaF, and then carrying out hydrothermal reaction and centrifugal separation to obtain OA-NaYF4:Yb,Er / Mn UCNPs; and 2) dispersing OA-NaYF4:Yb, Er / Mn UCNPs in alcohol, and then carrying out ligand exchange reaction with a trichloromethane and citrate solution to obtain the citrate modified NaYF4:Yb,Er / Mn up-conversion luminescent nano material. The citrate modified NaYF4:Yb,Er / Mn up-conversion luminescent nano material has the advantages of low detection limit, high sensitivity and good selectivity to hydrogen peroxide or uric acid detection, so that the material can be used for detecting uric acid in serum.

The invention provides a food convenient to eat and balanced in nutrition. The food is prepared from the following ingredients in percentage by weight: 20%-70% of coarse cereal ingredients, 5%-60% of vegetable ingredients, 2%-20% of nut ingredients and 0.1%-8% of flavoring ingredients. Through optimization, the food disclosed by the invention can be applied to ordinary crowds including but not limited to old people, children, women and the like. Through the optimization of the formula, the food disclosed by the invention can be applied to special crowds including but not limited to crowds with obesity, crowds with high blood lipid, crowds with high blood sugar and crowds with high uric acid. According to the food and the preparation method thereof disclosed by the invention, natural food raw materials are used and are processed by a modern method, so that the nutrition and the flavor of the raw materials are maximumly reserved, no pigments, no preservatives, no stabilizing agents and the like are added, and the food is healthy and safe. The food disclosed by the invention is powdered, and after the food is brewed, the brewed food can be eaten, so that the food is convenient to eat and has a high application value. The method disclosed by the invention is simple and convenient to operate and suitable for industrial production, and has great economic benefits and social benefits.

The invention relates to an electrochemical sensor capable of simultaneously detecting dopamine, ascorbic acid and uric acid. The electrochemical sensor comprises a work electrode, a reference electrode, and a counter electrode; wherein the substrate electrode of the work electrode is a glass-carbon electrode, the surface of the work electrode is coated with a composite material of graphene and mesoporous ferroferric oxide, the reference electrode is a saturated calomel electrode (SCE), and the counter electrode is a platinum wire electrode. Under an optimum condition, the electrochemical sensor can achieve the measurement of a single substance in a high concentration of coexisting substances, and can also simultaneously detect dopamine, ascorbic acid and uric acid. The electrochemical sensor not only avoids the phenomenon that the summit potentials of dopamine, ascorbic acid and uric acid overlap with each other, but also improves the sensitivity, repeatability, and stability of the conventional method.

Application of sunflower disc hydrolysis compound powder in preparing of food, medicine or food and medicine composition for preventing, curing or relieving blood uric acid rising-related diseases belongs to the technical field of biological medicine. According to the sunflower disc hydrolysis compound powder, by a method of hydrolyzing a soak solution of a sunflower disc with enzyme, on the basis of not damaging original components of the sunflower disc as much as possible, plant large molecules in the sunflower disc are hydrolyzed into micro-molecule polypeptide. It is found for the first time in research that the sunflower disc hydrolysis compound powder has an action of preventing rising of blood uric acid in animals, and also has a potential action of reducing high uric acid formed in blood. Therefore, the sunflower disc hydrolysis compound powder should be applied in preparing of food, medicine or food and medicine composition for relieving or curing gout.

The invention relates to a biological sensing chip, which is applicable to the fast diction of various indexes in the blood, including the indexes of cholesterin, triolein, blood sugar protein, blood sugar, lactic acid, uric acid, blood pH, blood oxygen and the like. The invention particularly relates to a dry enzyme method biochip / test strip, which belongs to the technical field of fast detection of a medical miniature biosensor. The dry enzyme method biochip comprises a base sheet, a dry enzyme work electrode, a reference electrode, a test liquid diffusing reticular film and hydrophobic insulation paint, wherein the dry enzyme work electrode and the reference electrode are 10 nm to 30 mum higher than the base sheet, the test liquid diffusing reticular film has the hydrophilicity, the contact angle of the test liquid diffusing reticular film and the pure water is approximately zero degree, and the test liquid including whole blood, blood serum, blood plasma or other tested liquid can be uniformly permeated and diffused onto the dry enzyme work electrode through the reticular film, so various blood parameters or other organic and inorganic liquid parameters can be tested by an electrochemical method.

The invention provides a uric acid reducing food composition which comprises the following components in parts by weight: 22-28 parts of marine fish oligopeptide powder, 25-35 parts of lophatherum gracile powder, 18-22 parts of poria cocos powder and 450-550 parts of soybean peptide. The composition provided by the invention has the following technical effects: 1) uric acid is reduced, and gout is relieved; 2) the composition is safe without side effects and causes no burden to body; and 3) the component marine fish oligopeptide can inhibit the synthesis of uric acid, the diuresis effect of lophatherum gracile and poria cocos can promote excretion of uric acid, and the soybean peptide supplements the proteins necessary to body and improves the basic metabolic capability and has a function of accelerating metabolism of uric acid in body.

The invention relates to health tea with effects of decreasing uric acid and protecting the liver and the kidney and a preparation method thereof. The health tea is prepared from the following raw materials in parts by weight: 20 to 30 parts of kudzuvine roots, 20 to 28 parts of coix seeds, 20 to 25 parts of herba lophatheri, 15 to 25 parts of Poria cocos, 10 to 15 parts of radix glycyrrhizae, 10 to 15 parts of fresh rhizoma imperatae, 8 to 15 parts of folium mori, 5 to 10 parts of fructus lycii, 5 to 10 parts of cordyceps militaris and 1 to 2 parts of enzyme powder. The health tea has the effects of decreasing uric acid and protecting the liver and the kidney, and the functions of clearing away heat and toxic materials, decreasing uric acid and the like are achieved through the effective ingredients; the ingredients such as the herba lophatheri and Poria cocos contained in the health tea are relatively high in diuretic effects, and are absorbed by intestines and stomach when tea water enters the human body, so that the effect of neutralizing alkaline substances in blood is achieved, the alkaline substances are discharged metabolically in a urine form, urate dirty in the kidney can be cleaned, and the capacity of the kidney for filtering out uric acid is increased.

The invention belongs to the field of health beverages, and in particular relates to a gynura procumbens compound preparation as well as a preparation method and application thereof. The gynura procumbens compound preparation is characterized by being prepared from the following raw materials in percentage by weight: 75-85% of gynura procumbens, 5-10% of barley seedlings, 3-6% of common lophatherum herb, 2-5% of frostbitten mulberry leaves, 2-4% of kudzuvine root and 1-3% of poria cocos. The preparation method of the gynura procumbens compound preparation comprises the following steps: performing weighing, drying and small fire baking on gynura procumbens, then mixing with other weighed raw materials, and crushing. The preparation disclosed by the invention is safe, healthy and natural, has various effects of treating gout in multiple ways comprehensively, can play roles in adjusting uric acid metabolism, promoting excretion of uric acid, preventing uric acid crystallization, diminishing inflammation and relieving pain, and controlling arthralgia, swelling and inflammations in an attack stage of gout, also can be used for reducing the blood lipid and blood sugar and strengthening kidney metabolism, can be used for treating both symptoms and root causes and achieving the effects of preventing and treating gout, and has the characteristics of natural compounds and natural health maintenance; and the preparation method disclosed by the invention is simple and convenient, and can be used for keeping original components of the raw materials to the greatest extent.

The invention discloses a lactobacillus plantarum UA-416 strain and application thereof, and belongs to the field of functional food microbes. Blanks of lactobacillus plantarum in the effects of lowering uric acid and resisting gout are filled up. According to the lactobacillus plantarum (Lactobacillus plantarum) UA-416 strain provided by the invention, the bacterial strain is already collected inthe China Center for Type Culture Collection (CCTCC) on July 25, 2017; the collection number is CCTCC NO: M2017419. The lactobacillus plantarum UA-416 strain provided by the invention can be used foreffectively lowering the level of blood uric acid, is used for improving the levels of urea nitrogen and creatinine and inhibiting the activity of xanthine oxidase in serum, and has prevention and treatment effects on uricemia or the gout.

The invention provides a micro-fluidic paper chip for simultaneously detecting glucose, uric acid, triglycerides and cholesterols, and its manufacturing method. The paper chip is a novel personalized diagnosis device, can rapidly, cheaply and simply detect multiple components without instrument equipment or professional people, can be operated by a patients or their families, and can momentarily and rapidly detect the concentrations of the glucose, the uric acid, the triglycerides and the cholesterols in blood.

The invention discloses a serum creatinine detecting reagent, and belongs to the technical field of clinical in-vitro detection. According to the serum creatinine detecting reagent, gamma-Fe2O3 nano-particles are added into a reagent R1, so that the activity of peroxidase and the specificity to a substrate are enhanced, and the interferences of reducing substances, such as ascorbic acid, uric acid, glutathione and bilirubin, are reduced; meanwhile, the gamma-Fe2O3 nano-particles also serve as a catalyst of a reaction; the interference of endogenous creatine is effectively eliminated by the combination action of the gamma-Fe2O3 nano-particles and the peroxidase. In addition, the serum creatinine detecting reagent adopts N-ethyl-N-(2-hydroxy-3-sulfonated propyl)-3-methylaniline sodium salt (TOOS) as a chromogen, so that the reagent is more stable; the analysis sensitivity is high. The substances, such as lipase and lipoprotein lipase, are also added into the reagent R1, so that the influence of lipid turbidity can be removed effectively; therefore, the reagent of the invention has higher anti-jamming capability and stability.

The invention discloses an alga ferment healthcare solid drink. The alga ferment healthcare solid drink is prepared from the following raw materials in percentage by weight: 5-13% of spirulina platensis, 8-10% of spirulina maxima, 5-15% of chlorella pyrenoidosa powder, 10-12% of haematococcus pluvialis, 10-13% of euglenophyta, 10% of alpha-amylase, 5% of lipase, 10% of cellulase, 5% of protease and 15% of fructo-oligosaccharides. A preparation process of the alga ferment healthcare solid drink comprises the following steps: (1) selecting and baking the materials; (2) drying; (3) adding the fructo-oligosaccharides; (4) crushing, purifying and sterilizing; (5) mixing; (6) carrying out incense enhancing and equalization treatment; (7) packaging. Compared with the prior art, the alga ferment healthcare solid drink has the advantages that natural raw materials serve as effective ingredients, and the intake and absorption of villi are controlled in the intestinal tract; the metabolic balance of the intestinal tract is regulated, and the value of uric acid in blood can be more effectively reduced; gout is prevented and improved, the propagation of beneficial bacteria of the intestinal tract is improved, the breeding of miscellaneous bacteria of the intestinal tract is inhibited, and the content of oxygen in the blood is increased; the immune system is regulated, and the immunity is enhanced.

The invention provides an electrochemical uric acid test strip comprising an insulating substrate (1), a working electrode (2) and a counter electrode (3), wherein the working electrode (2) and the counter electrode (3) are arranged at a first end of the insulating substrate (1) side by side at an interval; the working electrode (2) is provided with an anti-interference reagent layer; the components of the reagent layer comprise an ascorbic acid oxidase, a macromolecular compound and a buffering solution; and the components of the working electrode (2) comprise a non-aqueous redox electron transfer mediator. The invention further provides a manufacturing method of the electrochemical uric acid test strip. The test strip provided by the invention utilizes the non-water-soluble electron transfer mediator and combines an interference-removing enzyme layer, so that the effect of removing ascorbic acid is obvious. In a test, the interference of the ascorbic acid on uric acid test is very small.

The invention relates to a method for rapidly detecting urine sugar and uric acid in a solution. According to a method, a printer is adopted, paper AKD is used as a hydrophobic material, a paper chip is made on a piece of filter paper to serve as a detection carrier. Glucose oxidase and horse radish peroxidase are used as catalysis reagents for urine sugar detection, and potassium iodide is used as a coloration reagent. The uric acid detection is performed by adopting a UOD-POD two-enzyme method. The reagents are supported in a detection zone on the paper chip. After the chip is completely dried, standard urine sugar and uric acid solutions or sample solutions different in concentration are detected, photographing is performed, pictures are processed to obtain RGB color intensity values, and standard curves about the RGB color intensity values and the concentrations of the standard solutions are established. The method utilizes high selectivity of enzymatic reaction, combines the simple and convenient paper chip and the visual properties and high sensitivity of multielement detection and chemiluminescence imaging, fully plays the advantages of the three parts, and has the advantages of being low in cost, simple in operation, rapid, easy to operate and the like.

A method for lowering elevated uric acid levels in patients is disclosed and consists of administering to the patients an intravenous injection of PEG-uricase having a dosage from about 4 to about 12 mg.

The invention discloses a preparation method for 1, 3, 7, 9-tetramethyluric acid, which relates to a preparation method for purine biology alkalies compound in the chemical field. Specifically, fruits of Camellia assamica var.kucha are used as raw materials, water is used for extraction, and the extracting solution is extracted from chloroform or dichloromethane; after the chloroform or dichloromethane is recycled, the ethanol solution with a volume percentage concentration of 50 to 100 percent or methanol is used as a solvent to be re-crystallized, and the 1, 3, 7, 9-tetramethyluric acid with 99 percent purity can be obtained. The preparation method for the 1, 3, 7, 9-tetramethyluric acid has the beneficial effects: 1. the preparation method has the advantage of waste utilization; 2. the preparation method with the advantages of simple technological process, little solvent usage, economy and time saving can realize industrialized production; 3. the product is high in purity and high in yield.

The invention discloses a method for preparing biological active peptide with an effect of reducing trioxypurine by using walnut protein. The method comprises the following steps: watering and grinding the walnut protein; adding alkaline protease and cellulose; deactivating enzyme and centrifuging when the degree of hydrolysis achieves 10-15%, so as to obtain walnut protein enzymatic hydrolysate; filtering the enzymatic hydrolysate by virtue of an ultrafiltration membrane and strong acid gel type cation exchange resin, so as to obtain the biological active peptide with the effect of reducing trioxypurine. The biological active peptide is prepared by combining biological enzymolysis with a chromatographic separation technology; the target active peptide has a significant effect of reducing trioxypurine. An animal experiment in rats proves that the peptide for reducing trioxypurine prepared by the method disclosed by the invention can be used for significantly reducing the serum creatinine level of the rat, and has a certain degree of protective effect on the renal function of the rat, and strong activity of reducing the trioxypurine.

The invention relates to a test paper strip of using color reaction to detect the concentration of uric acid in urine. It includes test paper base material, its feature is that: enzyme color developing reagent adheres to test paper base material. The beneficial effect of this invention is that, the detector can detect the concentration of uric acid in urine in own home, so as to preliminary reach the range of uric acid content in the urine, thus it is certain guiding significance for the blood uric acid content.

The invention discloses a health-care food suitable for patient with type 2 diabetes mellitus, in particular to a health-care food suitable for overweight and obesity patient with type 2 diabetes mellitus. The health-care food is prepared by uniformly mixing the following raw materials in parts by weight: 20-120 parts of Avena nuda, 1-15 parts of Moringa leaf powder, 1-5 parts of yeast powder and 1-5 parts of wheat germ. The method for eating the health-care food is as follows: 400ml of water is added in 40g of health-care food, the mixture is boiled for 1-2 minutes, and subsidiary food is matched according to diabetes food management, wherein the health-care food as the main food is taken twice a day by 40g each time for 12 weeks. The health-care food has the advantages of low treatment cost and no toxic or side effect, is favorable for improving sugar, fat and uric acid metabolism and high INS (insulin secretion) septicemia of a patient, reversing fatty liver and controlling hypertension, and is also favorable for patients to insist in orally taking drug for lowering blood sugar, raw materials are abundant, the weight of overweight and obesity patient with type 2 diabetes mellitus can be lowered.