741 results about "Uric acid" patented technology

A forest fire retardant composition contains a retardant compound that includes a potassium salt. The potassium salt may include a potassium salt of an organic acid, a potassium salt of an inorganic acid, or mixtures thereof. The organic acid may include formic acid, acetic acid, propanoic acid, butanoic acid, lactic acid, oxalic acid, malic acid, gluconic acid, tartaric acid, uric acid, malic acid, or citric acid. The inorganic acid may include sulfuric acid, phosphoric acid, carbonic acid, or hydrochloric acid. The composition may be in the form of a dry concentrate, a liquid concentrate, or a final diluted product. The final diluted product is effective in suppressing, retarding, and controlling forest fires while exhibiting corrosion resistance and low toxicity.

The invention relates to the technical field of microorganisms, and in particular relates to application of a strain of lactobacillus mucus TG018. The invention further relates to a preparation method of the lactobacillus mucus TG018. The preservation number of the lactobacillus mucus TG018 is CCTCC (China Center for Type Culture Collection) No: M 2023514; the lactobacillus mucus TG018 can be used for producing nicotinic acid, serving as an antioxidant and / or preparing the antioxidant, or can be applied to medicines for reducing uric acid.

The invention relates to the field of natural products, in particular to a dimer compound of guaiane type sesquiterpenes and uric acid as well as an extraction and separation method and application of the dimer compound. According to the invention, a new dimer compound of guaiane type sesquiterpene and uric acid is extracted and separated from carpesium abrotanoides in Guizhou, and it is found that the dimer compound has relatively strong anti-tumor activity. The compound has strong inhibitory activity on breast cancer, prostate cancer, nasopharynx cancer, liver cancer, lung cancer, leukemia, pancreatic cancer, glioma, osteosarcoma, skin cancer, cervical cancer, ovarian cancer, kidney cancer and esophageal cancer, and provides an optional scheme for broad-spectrum anti-cancer drugs. Moreover, in human prostate cancer cells PC3, human cervical cancer cells Hela, human liver cancer cells HepG2 and human glioma cells U87 which are resistant to paclitaxel, the compound also shows strong anti-cancer activity, which indicates that the compound has the potential of treating patients resistant to paclitaxel.

The invention relates to the technical field of food, in particular to diglyceride for reducing triglyceride, cholesterol and uric acid as well as a biological enzyme preparation method and application of the diglyceride. The preparation method comprises the following steps: (1) adding water and glycerol into vegetable oil, and then adding immobilized lipase to react to obtain a reactant; (2) centrifuging reactants, collecting a light-phase product, carrying out molecular distillation, and collecting a heavy-phase product to obtain diglyceride; the immobilized lipase comprises lipase and a carrier, the carrier comprises loofah sponge, soybean meal and bentonite, and the mass ratio of the loofah sponge to the soybean meal to the bentonite is 1: (2-4): (3-6). The method has the advantages that the effects of reducing triglyceride, total cholesterol and uric acid are relatively good, and the yield and the purity are relatively high.

The invention discloses a measurement method, system and related device, the method is applied to first electronic equipment, the first electronic equipment comprises a first electrode group and a second electrode group, and the distance between the first electrode group and the second electrode group is greater than a first distance; under the condition that a first electrode group and a second electrode group are implanted into subcutaneous tissue, the method comprises the following steps: determining a first physiological parameter through the first electrode group; electrocardiosignals are determined through the first electrode set and the second electrode set. Therefore, the electrocardiosignal of the user can be obtained anytime and anywhere through the first electronic equipment, and one or more other physiological parameters (such as blood glucose, blood ketone, blood lactic acid and uric acid) of the user can be measured at the same time, so that the health monitoring efficiency is improved.

The invention belongs to the technical field of probiotics and application thereof, and relates to a probiotic capable of reducing uric acid and a product thereof, in particular to a strain of Lentilactobacillusbuchneri strain ZD62 which is preserved in China Center for Type Culture Collection on March 14, 2024, the preservation address is Wuhan University, Wuhan, China, and the preservation number is CCTCC NO: M2024469, and the preservation number is CCTCC NO: M2024469, the preservation number is CCTCC NO: M2024469, the preservation number is CCTCC NO: M2024469, and the preservation number is CCTCC NO: M2024469. The invention relates to a compound probiotic agent, which is prepared from Lentilactobacilli buchneri strain ZD62 and Mycobacterium fermentum ZD103, and is characterized in that the Mycobacterium fermentum ZD103 is prepared from Lentilactobacilli buchneri strain ZD62; the lactobacillus buchneri ZD62 and the mucus fermentum ZD103 provided by the invention have a good characteristic of reducing uric acid.

According to the preparation method of the Mn-based multifunctional nano-enzyme, the Mn-based multifunctional nano-enzyme and the application, the metal frame ZIF-8 is used as a template, Mn is uniformly dispersed in a metal organic frame, and then calcination is performed in an inert atmosphere to successfully realize uniform dispersion of an Mn catalyst on a ZIF-8-derived nitrogen-doped dodecahedron carbon material to form the Mn-based multifunctional nano-enzyme. The optimal valence state proportion of Mn and the optimal manganese coordination structure are obtained by regulating and controlling the Mn doping amount, the carbonization temperature and the like, so that the Mn-based multifunctional nano-enzyme with good UOD, CAT and SOD performance is obtained, and the purposes of rapidly reducing uric acid and hydrogen peroxide and eliminating inflammation are achieved.

The invention discloses a Lactobacillus paracasei strain with a uric acid reducing function and application thereof, the Lactobacillus paracasei strain is named as Lactobacillus paracasei C125, and is preserved in China Center for Type Culture Collection on February 17, 2025, the preservation number is CCTCC M 2025231, and the preservation address is Wuhan University, Wuhan University, No. 299, eight road, Wuchang District, Wuhan City, Hubei Province. The fermentation supernatant of the casei paracasei has the functions of reducing uric acid, resisting oxidation and inhibiting bacteria, and has a wide application prospect.

The invention relates to the technical field of medical image processing and intelligent diagnosis. The image recognition method for the urinary system calculus comprises the steps that a dynamic video stream of a calculus area is obtained through an endoscope image collection module, and a current frame image is extracted; performing illumination compensation processing on the image, eliminating vascular interference and light reflection, and enhancing the boundary of a calculus main body; based on multispectral feature fusion, separating yellow-like spectrum features of uric acid stones and grey-white-like spectrum features of calcium stones, and calculating stone surface color distribution dispersion; performing multi-angle texture energy detection by adopting a direction sensitive convolution kernel to generate a calcification crystallization density coefficient; inputting the color distribution dispersion and the calcification crystallization density coefficient into a decision tree model, and outputting a calculus type identifier; and according to the stone type identifier and the three-dimensional projection area of the stone contour, frequency-energy combination parameters of the laser stone crusher are generated, and the laser pulse emission time sequence is controlled in real time.

The invention relates to the technical field of fermentation of edible and medicinal fungi, and discloses a phellinus igniarius fermentation method capable of producing high-yield Hispidin and an application of the phellinus igniarius fermentation method. The phellinus igniarius fermentation method comprises the following steps: inoculating a phellinus igniarius strain into a culture medium containing a copper ion compound, and fermenting. The phellinus igniarius mycelium obtained by adopting the fermentation method is rich in Hispidin, and can be widely used for preparing related medicines and health foods for protecting liver, resisting tumors, resisting viruses, resisting oxidation, reducing uric acid and the like. In addition, the invention also discloses a high performance liquid chromatography detection method for analyzing the content of Hispidin, by adopting the method, the content of Hispidin and precursor substances (such as protocatechuic acid, protocatechualdehyde, caffeic acid, osmundone and the like) in the phellinus igniarius leavening and derivative products thereof as well as phellinus igniarius mycelia can be effectively analyzed, and the accuracy of Hispidin detection is favorably improved.

The invention discloses camel milk polypeptide with xanthine oxidase inhibitory activity and application thereof.The camel milk polypeptide is prepared by taking fresh camel milk as a raw material, conducting low-temperature centrifugation to remove fat, conducting triple enzymolysis through papain, pepsin and trypsin to obtain enzymatic hydrolysate, enabling the enzymatic hydrolysate to pass through an ultrafiltration membrane (the molecular weight cutoff is 10 kDa) to obtain filtrate, and conducting freeze-drying to obtain the camel milk polypeptide. The compound has xanthine oxidase inhibitory activity. The invention also discloses a small molecule polypeptide with xanthine oxidase inhibitory activity. The filtered solution is screened and combined with polypeptides by adopting a xanthine oxidase affinity ultrafiltration method, the activity of the polypeptides is verified through molecular docking and in-vitro enzyme inhibition, four small-molecule polypeptides with xanthine oxidase inhibitory activity are obtained, the sequence of the small-molecule polypeptides is shown as any one of SEQ ID NO.1-4, and the small-molecule polypeptides can be used for preparing drugs with the effect of inhibiting the uric acid level.

The invention discloses a sweat uric acid and glucose sensor based on a carbon nanotube (CNT) enhanced electrochemical platform, and aims to solve the sensitivity challenge of low-concentration biomarker detection in sweat. The enzyme is covalently immobilized on the CNT through an EDC / NHS chemical method, so that the catalytic efficiency, the electron transfer speed and the sensor stability are remarkably improved, and the ultralow detection lower limit of uric acid and glucose is realized. According to the device, uric acid, glucose and pH sensing functions are integrated on a single wearable platform, efficient flowing and rapid updating of sweat are ensured through a radiation symmetry microfluid design optimized through finite element analysis, and real-time biomarker monitoring is supported. The material innovation (such as CNT-enzyme complex) and fluid dynamics optimization of the invention overcome the key problem in the field of wearable biosensing, and provide an extensible solution for the next generation of non-invasive health monitoring.

The invention belongs to the technical field of biochemistry, and particularly relates to a rice residue oligopeptide and application thereof in reducing uric acid, and the amino acid sequence of the rice residue oligopeptide is any one of SEQ ID NO: 3, SEQ ID NO: 9 and SEQ ID NO: 10. The rice residue oligopeptide can realize multi-target simultaneous intervention of multiple links of uric acid metabolism, has the characteristics of inhibiting uric acid generation, promoting uric acid excretion and resisting oxidation, can realize an excellent uric acid reducing effect, and provides a further theoretical basis for deep development of rice processing byproducts.

The invention discloses a preparation method and application of a medicinal and edible composition for reducing uric acid and treating gout, and belongs to the crossing field of medicine and food technologies. The composition is composed of celery seeds, sophora flower buds, chicory, dandelion, mulberry twigs, pawpaw and fresh lalang grass rhizomes, all the components have a synergistic effect, and the effects of inhibiting generation of uric acid, promoting excretion of uric acid, resisting inflammation, diminishing swelling and adjusting body metabolism at multiple target points are achieved. The preparation method comprises the steps of intelligent screening and fine pretreatment of raw materials, a multi-stage targeted extraction process and intelligent concentration and precise forming, and active ingredients can be efficiently extracted and prepared into various dosage forms. According to the composition, in the aspect of precise medical assistance, personalized medication schemes are customized according to different stages of gout, and whole-course digital management is achieved by means of intelligent equipment and a cloud platform; in daily smart health care of families, gout prevention of the families is facilitated through smart home kitchen equipment and a uric acid monitoring set; the method is used for innovative health food development, and provides a new natural, efficient and multifunctional health management approach for gout patients.

The preparation method comprises the following steps: centrifuging an activated culture solution of animal bifidobacterium subsp. Lactis HNU212 to remove a supernatant, washing with 0.9% normal saline, adjusting the strain concentration to 1 * 10 < 9 > CFU / mL, and inactivating at 90 DEG C for 15 minutes, thereby obtaining the thermal inactivation bifidobacterium subsp. Lactis metagen. The invention also provides a preparation method of the thermal inactivation bifidobacterium subsp. Lactis metagen, and the preparation method of the thermal inactivation bifidobacterium subsp. Lactis metagen comprises the following steps of: preparing the thermal inactivation bifidobacterium subsp. Lactis metagen and the preparation method of the thermal inactivation bifidobacterium subsp. Lactis metagen. When applied to an HUA animal model, the thermal inactivation substance bifidobacterium subsp. Lactis metaplasm prepared by the invention can effectively reduce the serum uric acid level, relieve kidney and intestinal injury and regulate host intestinal flora, and has the effect of relieving and treating HUA.

The invention discloses a method for preparing uric acid-reducing diglyceride through enzymolysis and a product and application thereof, and belongs to the technical field of diglyceride production, the method comprises the following steps: (1) mixing vegetable oil, glycerol, water and an enzyme preparation for reaction to obtain a reaction solution; (2) standing and layering the reaction liquid, and collecting supernatant; (3) performing distillation separation on the supernatant, and performing decoloration and deodorization to obtain diglyceride; the enzyme preparation in the step (1) is prepared from lipase Lipase, esterase Esterase and phospholipase C in a weight ratio of (5-10): (0.1-0.3): 1. Compared with the prior art, the method disclosed by the invention is simple and low in cost, and the prepared diglyceride has more advantages in the aspect of reducing uric acid.

The invention relates to the field of preparation and application of biological peptides, in particular to a swelling hippocampal peptide and application thereof in preparation of uric acid reducing and gout resisting products. The amino acid sequence is shown as SEQ ID NO.1-5. The uric acid reducing effect is verified by adopting an in-vitro XOD inhibition experiment and a cell experiment; furthermore, the uric acid reducing and gout resisting activity of the compound is verified through a hyperuricemia animal model, and a theoretical basis is provided for high-valued utilization of the belly-swelling hippocampus and development of uric acid reducing and gout resisting products.

The invention relates to the technical field of medicines, in particular to application of an active ingredient xanthohumol (XAN) derived from a traditional Chinese medicine humulus lupulus in preparation of medicines for reducing uric acid and resisting gout, and the xanthohumol (XAN) can be prepared into various oral preparations, injection preparations and external preparations with the assistance of pharmaceutically acceptable auxiliary materials and has good development and application prospects. The inventor finds that the xanthohumol has relatively strong effects of reducing blood uric acid, resisting inflammation, resisting bone damage and the like, and the mechanism of the effect of reducing the blood uric acid is that the activity of xanthine oxidase is inhibited so as to reduce the generation of uric acid, and the renal function of an organism is improved so as to enhance uric acid excretion; according to the anti-inflammatory effect, the inflammatory reaction is relieved mainly by down-regulating the levels of inflammatory factors such as IL-1beta, IL-6, TNF alpha and PEG2; the mechanism for resisting gout bone damage is realized through the fact that RANKL / OPG / RANK signal pathway participates in bone metabolism regulation.

The invention discloses a non-enzymatic uric acid electrochemical sensor based on quaternary ammonium salt modified MXene, a method and application, and belongs to the technical field of sensors. The preparation method comprises the following steps: preparing an MXene material through an etching method; the preparation method comprises the following steps: modifying an MXene material by adopting quaternary ammonium salt to obtain a modified MXene material; a working electrode is modified with the modified MXene material, a reference electrode and a counter electrode are combined to form a three-electrode system, and the non-enzymatic uric acid electrochemical sensor based on quaternary ammonium salt modified MXene is obtained. The prepared non-enzymatic uric acid electrochemical sensor is excellent in performance, high in sensitivity and low in detection limit; the linear range is wide and covers the human blood uric acid concentration range; the stability is good, and the influence by temperature and pH is avoided; the biological compatibility is good, the antibacterial property is good, and the toxicity is low. The sensor can realize rapid and quantitative detection of human blood uric acid concentration, has excellent detection performance, and has no obvious difference with the detection result of a large biochemical analysis instrument.

The invention provides a molecularly imprinted electrochemical sensor for hippuric acid detection, a preparation method and a segmented response technology, and belongs to the technical field of electrochemical sensors. Based on functional monomers aniline and o-phenylenediamine, hippuric acid is taken as a template molecule, and the molecularly imprinted electrochemical sensor for detecting hippuric acid is prepared by an electrochemical polymerization method, and combines the advantages of a molecular imprinting technology and an electrochemical technology; the hippuric acid detection sensor has excellent sensitivity, fast response time and specific recognition capability, has good signal response to hippuric acid detection under different concentrations, generates a good electric signal in a hippuric acid solution of 0-100 nM, forms a better linear relationship between the electric signal generated in the hippuric acid solution with the concentration of 100 nM or above and the concentration, and can be applied to the detection of hippuric acid with the concentration of 100 nM or above. The signal response and detection range of the molecularly imprinted electrochemical sensor under high concentration is widened, and the molecularly imprinted electrochemical sensor is suitable for hippuric acid detection in a wide range.

The embodiment of the invention discloses a uric acid data acquisition and anomaly detection method and device based on multi-modal fusion. A specific embodiment of the method comprises the following steps: controlling a medical data query end to query a historical uric acid detection data set corresponding to uric acid detail retrieval information; performing image enhancement processing on the initial uric acid detection image according to a pre-trained uric acid detection image enhancement model to generate an enhanced uric acid detection image; performing uric acid area identification on the enhanced uric acid detection image to obtain a uric acid identification area image group; optimizing each uric acid recognition area image in the uric acid recognition area image group to generate an optimized uric acid recognition area image, and obtaining an optimized uric acid recognition area image group; and inputting the historical uric acid detection data set and the optimized uric acid recognition area image group into a pre-trained multi-mode uric acid anomaly detection model to generate a uric acid anomaly detection result. According to the embodiment, the detection accuracy is improved, and accurate dynamic detection of uric acid abnormity is realized.

The invention provides a composite quality control liquid for an electrochemical multi-parameter detector. The composite quality control liquid comprises a buffer volume, a quality control substance and a stabilizer, the stabilizing agent comprises 5 to 50 g / L of bovine serum albumin, 0.1 to 10 g / L of EDTA-2Na (Ethylene Diamine Tetraacetic Acid), 10 to 100 g / L of a viscosity regulator, 0.3 to 25 g / L of a preservative and 5 to 20 g / L of a surfactant; the preparation method comprises the following steps: adding components of the stabilizer into a buffer system, preparing a preparation solution, preparing mother liquor of each quality control substance, proportionally mixing glucose mother liquor, uric acid mother liquor, beta-hydroxybutyric acid mother liquor and cholesterol sodium sulfate and triglyceride composite mother liquor according to the target concentration of the quality control solution, and fixing the volume by using the preparation solution to obtain the quality control liquid. And fully and uniformly mixing to obtain the composite quality control liquid. The composite quality control liquid can ensure that uric acid is not degraded, cholesterol triglyceride is not separated out, the formula is mild, and active substances in a detection system are not influenced.

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus mucus BU360 with the function of improving uric acid, blood fat and blood glucose metabolism and application of the lactobacillus mucus BU360. The preservation number of the lactobacillus fermentum BU360 provided by the invention is CGMCC (China General Microbiological Culture Collection Center) No.33032. The lactobacillus fermentum BU360 provided by the invention has the advantages that the preservation number is CGMCC No.33032; the lactobacillus mucus BU360 can efficiently degrade guanosine and inosine which are precursor substances for synthesizing uric acid and directly degrade the uric acid, thalli, cell contents and metabolites of the lactobacillus mucus BU360 can inhibit the activity of xanthine oxidase and relieve HUA, and the lactobacillus mucus BU360 can directly degrade cholesterol and inhibit the activity of alpha-glucosidase and alpha-amylase, so that the lactobacillus mucus BU360 can be used for preparing the uric acid. The polypeptide has potential capability of improving blood fat and blood glucose metabolism abnormality, and assists in treatment of HUA; besides, the strain has relatively strong acid-resistant and cholate-resistant characteristics, can smoothly reach the intestinal tract of a human body, has relatively good safety on sensitivity of various antibiotics, and lays a foundation for development of related probiotic products. The lactobacillus mucus BU360 has a wide application prospect in the aspect of preparing products for relieving HUA, improving blood fat and blood glucose metabolism and the like.

The invention provides an eye drop composition as well as a preparation method and application thereof, and belongs to the technical field of ophthalmic preparations. The eye drop composition adopted by the invention is prepared from the following components: brimonidine tartrate, hyaluronic acid, collagen, trehalose and injection water. By compounding the components, the eye drops which can realize slow release of brimonidine tartrate and prolong the antihypertensive action time and have the characteristics of relieving blink discomfort, long-acting moisturizing, anti-inflammatory soothing, mildness, corrosion prevention and the like are prepared; the eye drops are beneficial to people suffering from glaucoma, intraocular hypertension, xerophthalmia, postoperative inflammation or allergy and preservative sensitivity or preservative allergy, the life quality is improved, and diseases are relieved.

A test strip for detecting uric acid in saliva that meets the requirement for room-temperature preservation, a preparation and detection method therefor and the use thereof. The test strip for detecting uric acid in saliva comprises a uricase, a peroxidase, a vitamin C oxidase, a bilirubin oxidase, a color developing agent, and a protective film coated on the test strip for detecting uric acid in saliva. To meet the needs of a target population for long-term monitoring and real-time tracking of changes in their uric acid levels, by means of agent addition, the test strip for detecting uric acid in saliva has prolonged preservation time at room temperature, enables non-invasive, efficient and convenient monitoring of a health status at any time, and timely detection and treatment, allows intuitive visual identification of uric acid levels in saliva by a subject, and meets the needs of a subject for long-term preservation at room temperature.

The invention belongs to the technical field of biological medicines, and relates to a bionic integrated nano enzyme for effectively relieving gouty arthritis and inhibiting recurrence. The biomimetic integrated nano-enzyme is composed of a platinum nano-enzyme, hollow Prussian blue and a macrophage cell membrane. The bionic integrated nano enzyme can quickly and effectively relieve joint swelling caused by gouty arthritis and inhibit repeated recurrence of the gouty arthritis. The hollow Prussian blue loaded with the platinum nano-enzyme and a bionic preparation coated with a macrophage membrane are further prepared, the capabilities of catalyzing uric acid decomposition and removing active oxygen of the platinum nano-enzyme and the effects of targeting in vivo inflammation and rapidly relieving gout can be remarkably improved, and recurrence of the gout is inhibited. According to the invention, multi-strategy and multi-means treatment of gouty arthritis is facilitated, and the problems of rapid onset and easy recurrence of gouty arthritis are solved.

The invention discloses a siraitia grosvenorii instant coffee beverage assisting in reducing uric acid and a preparation method thereof, and belongs to the technical field of food based on the theory of homology of medicine and food. The coffee beverage is composed of instant coffee powder, a compound sweetening agent, coconut milk powder, milk powder and composite herbal powder in a specific proportion. The compound herbal powder is composed of poria cocos, peach kernels, dried tangerine or orange peel and momordica grosvenori which are selected from a medicinal and edible substance catalog. The herbal active ingredients and a coffee system are deeply fused by optimizing an extraction process, the dual regulation effects of inhibiting xanthine oxidase and promoting uric acid excretion are synergistically exerted, and the technical contradiction that common caffeine possibly affects uric acid excretion is effectively solved. The zebra fish in-vivo experiment proves that the level of uric acid can be remarkably reduced (Plt: 0.001), the improvement rate is as high as 17.63%, and a safe and effective daily diet intervention scheme is provided for people with hyperuricemia while the coffee flavor and convenience are provided.

The invention relates to the technical field of food sustained-release preparations, and particularly discloses a sour cherry powder sustained-release preparation with a stable uric acid reducing effect and a preparation process of the sour cherry powder sustained-release preparation. The sour cherry powder sustained-release preparation comprises a core active phase freeze-dried sour cherry powder, a sustained-release carrier phase, a synergistic function phase, an auxiliary regulation phase and a filler, the synergistic functional phase contains a celery seed extract, a curcumin-phospholipid complex, a prebiotic complex and the like, and all the components have a synergistic effect. The preparation method comprises the following steps: carrying out wall breaking, enzymolysis, purification and freeze-drying treatment on sour cherry fruits to obtain a core raw material, compounding the core raw material with other components, and carrying out slow-release carrier construction, coating granulation and other steps to prepare the microcapsule structure preparation. The preparation can be used for assisting in reducing the uric acid level, and has the advantages of high stability of active ingredients, continuous and stable uric acid reducing effect, consideration to intestinal health and the like; the preparation process adopts freeze-drying and micro-capsule coating technologies, effectively retains active ingredients, is controllable in operation, and is suitable for large-scale production.

The invention discloses a uric acid reducing composition and a preparation method and application of plant extracts of the uric acid reducing composition, and belongs to the technical field of traditional Chinese medicine formulas and preparation. The uric acid reducing composition is prepared from the following raw materials in parts by mass: 3 to 27 parts of corn stigma, 3 to 27 parts of pericarpium citri reticulatae and 3 to 27 parts of white kidney beans. The preparation method of the plant extract comprises the following steps: pretreating the raw materials, extracting effective components, compounding according to different proportions, evaluating the in-vitro xanthine oxidase inhibition effect by using the plant extract, determining the formula compatibility of the raw materials according to quantitative pharmacology, and further determining the formula compatibility of the uric acid reducing composition. The corn stigma is treated by adopting a steam wall breaking technology, so that the extraction rate of effective components of the corn stigma is remarkably improved, and the uric acid reducing effect of the product is enhanced; the uric acid reducing food prepared on the basis of the uric acid reducing composition is safe, free of side effects and suitable for being eaten by people with high uric acid for a long time.

A crystalline polymorph of uric acid characterized by powder X-ray diffraction, Raman spectroscopy and 1H-NMR, the process to obtain said crystalline polymorph starting from ethyl (6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)carbamate, a pharmaceutical composition containing crystalline polymorph and its use in the prevention and treatment of a cerebrovascular disease.