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990 results about "Uric acid" patented technology

Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C₅H₄N₄O₃. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. High blood concentrations of uric acid can lead to gout and are associated with other medical conditions, including diabetes and the formation of ammonium acid urate kidney stones.

Long-term fire retardant with corrosion inhibitors and methods for making and using same

A forest fire retardant composition contains a retardant compound that includes a potassium salt. The potassium salt may include a potassium salt of an organic acid, a potassium salt of an inorganic acid, or mixtures thereof. The organic acid may include formic acid, acetic acid, propanoic acid, butanoic acid, lactic acid, oxalic acid, malic acid, gluconic acid, tartaric acid, uric acid, malic acid, or citric acid. The inorganic acid may include sulfuric acid, phosphoric acid, carbonic acid, or hydrochloric acid. The composition may be in the form of a dry concentrate, a liquid concentrate, or a final diluted product. The final diluted product is effective in suppressing, retarding, and controlling forest fires while exhibiting corrosion resistance and low toxicity.
Owner:PERIMETER SOLUTIONS LP

Phytobacterium plantarum MPs-68 capable of adsorbing micro-plastics and degrading uric acid and application of phytobacterium plantarum MPs-68

The invention relates to the technical field of microorganisms, in particular to plant lactobacillus MPs-68 capable of adsorbing microplastics and degrading uric acid and application of the plant lactobacillus MPs-68. The provided plant lactobacillus MPs-68 capable of adsorbing microplastics and degrading uric acid is a marine-derived natural strain, the preservation number is CGMCC No.31976, the plant lactobacillus MPs-68 has a remarkable adsorption effect on microplastics polystyrene and polyethylene, has the function of degrading uric acid, and is high in oxidation resistance, gastric acid resistance, cholate resistance and intestinal colonization capacity, and the plant lactobacillus MPs-68 can be used for adsorbing microplastics and degrading uric acid. The method has important application value in the fields of food or health care products for assisting adsorption of micro-plastics and reduction of uric acid and the like. The invention also provides a microbial agent, a probiotic product, a functional food, a fermentation product, a microecological preparation, a microplastic adsorbent and a microplastic adsorbent compounded with the lactobacillus brevis MPA01 (the preservation number is CGMCC No.31977) containing the phytobacterium plantarum MPs-68 capable of adsorbing the microplastics and degrading the uric acid, and the microplastic adsorbent has the effects of adsorbing the microplastics, degrading the uric acid and the like.
Owner:XIAMEN YUANZHIDAO BIOTECHNOLOGY CO LTD

Application of lactobacillus mucilaginosus TG018

The invention relates to the technical field of microorganisms, and in particular relates to application of a strain of lactobacillus mucus TG018. The invention further relates to a preparation method of the lactobacillus mucus TG018. The preservation number of the lactobacillus mucus TG018 is CCTCC (China Center for Type Culture Collection) No: M 2023514; the lactobacillus mucus TG018 can be used for producing nicotinic acid, serving as an antioxidant and / or preparing the antioxidant, or can be applied to medicines for reducing uric acid.
Owner:XIAMEN TREATGUT BIOTECHNOLOGY CO LTD

Gout detection hearing aid system for monitoring uric acid level in real time by using sweat sensor

The embodiment of the invention discloses a gout detection hearing aid system for monitoring uric acid level in real time by using a sweat sensor, and relates to the technical field of hearing aid devices and algorithms. The hearing aid system comprises a hearing aid, a processor and a processor, the outer side of the flexible sweat sensor patch is used for being attached to the skin behind the ear, the inner side of the flexible sweat sensor patch is attached to the outer surface of the hearing aid, and the flexible sweat sensor patch is electrically connected with the hearing aid chip through a contact electrode; sweat of the skin behind the ear flows into the micro-channel through the sweat collecting hole, after an electric field is applied to the detection electrode, the level of uric acid in the micro-channel is measured through the Raman spectrum technology, and the uric acid is transmitted to the interior of the hearing-aid chip to be processed. And the disease monitoring system is used for recording detection data, analyzing gout risks and linking the hearing aid to carry out in-ear early warning when the data is abnormal. The system is noninvasive and portable, and can solve the problem of user hearing and gout management at the same time.
Owner:HANGZHOU HUIER HEARING INSTR & TECH CO LTD

Dimer compound of guaiane type sesquiterpenes and uric acid as well as extraction and separation method and application of dimer compound

The invention relates to the field of natural products, in particular to a dimer compound of guaiane type sesquiterpenes and uric acid as well as an extraction and separation method and application of the dimer compound. According to the invention, a new dimer compound of guaiane type sesquiterpene and uric acid is extracted and separated from carpesium abrotanoides in Guizhou, and it is found that the dimer compound has relatively strong anti-tumor activity. The compound has strong inhibitory activity on breast cancer, prostate cancer, nasopharynx cancer, liver cancer, lung cancer, leukemia, pancreatic cancer, glioma, osteosarcoma, skin cancer, cervical cancer, ovarian cancer, kidney cancer and esophageal cancer, and provides an optional scheme for broad-spectrum anti-cancer drugs. Moreover, in human prostate cancer cells PC3, human cervical cancer cells Hela, human liver cancer cells HepG2 and human glioma cells U87 which are resistant to paclitaxel, the compound also shows strong anti-cancer activity, which indicates that the compound has the potential of treating patients resistant to paclitaxel.
Owner:KUNMING MEDICAL UNIVERSITY +1

Diglyceride for reducing triglyceride, cholesterol and uric acid as well as biological enzyme preparation method and application thereof

The invention relates to the technical field of food, in particular to diglyceride for reducing triglyceride, cholesterol and uric acid as well as a biological enzyme preparation method and application of the diglyceride. The preparation method comprises the following steps: (1) adding water and glycerol into vegetable oil, and then adding immobilized lipase to react to obtain a reactant; (2) centrifuging reactants, collecting a light-phase product, carrying out molecular distillation, and collecting a heavy-phase product to obtain diglyceride; the immobilized lipase comprises lipase and a carrier, the carrier comprises loofah sponge, soybean meal and bentonite, and the mass ratio of the loofah sponge to the soybean meal to the bentonite is 1: (2-4): (3-6). The method has the advantages that the effects of reducing triglyceride, total cholesterol and uric acid are relatively good, and the yield and the purity are relatively high.
Owner:GUANGDONG ZHONGYAO OIL & FERTILIZER IND CO LTD

Measurement method, system and related device

The invention discloses a measurement method, system and related device, the method is applied to first electronic equipment, the first electronic equipment comprises a first electrode group and a second electrode group, and the distance between the first electrode group and the second electrode group is greater than a first distance; under the condition that a first electrode group and a second electrode group are implanted into subcutaneous tissue, the method comprises the following steps: determining a first physiological parameter through the first electrode group; electrocardiosignals are determined through the first electrode set and the second electrode set. Therefore, the electrocardiosignal of the user can be obtained anytime and anywhere through the first electronic equipment, and one or more other physiological parameters (such as blood glucose, blood ketone, blood lactic acid and uric acid) of the user can be measured at the same time, so that the health monitoring efficiency is improved.
Owner:HUAWEI TECH CO LTD

Probiotics capable of reducing uric acid and product

The invention belongs to the technical field of probiotics and application thereof, and relates to a probiotic capable of reducing uric acid and a product thereof, in particular to a strain of Lentilactobacillusbuchneri strain ZD62 which is preserved in China Center for Type Culture Collection on March 14, 2024, the preservation address is Wuhan University, Wuhan, China, and the preservation number is CCTCC NO: M2024469, and the preservation number is CCTCC NO: M2024469, the preservation number is CCTCC NO: M2024469, the preservation number is CCTCC NO: M2024469, and the preservation number is CCTCC NO: M2024469. The invention relates to a compound probiotic agent, which is prepared from Lentilactobacilli buchneri strain ZD62 and Mycobacterium fermentum ZD103, and is characterized in that the Mycobacterium fermentum ZD103 is prepared from Lentilactobacilli buchneri strain ZD62; the lactobacillus buchneri ZD62 and the mucus fermentum ZD103 provided by the invention have a good characteristic of reducing uric acid.
Owner:QILU UNIVERSITY OF TECHNOLOGY (SHANDONG ACADEMY OF SCIENCES) +1

Preparation method of Mn-based multifunctional nano-enzyme, Mn-based multifunctional nano-enzyme and application of Mn-based multifunctional nano-enzyme

According to the preparation method of the Mn-based multifunctional nano-enzyme, the Mn-based multifunctional nano-enzyme and the application, the metal frame ZIF-8 is used as a template, Mn is uniformly dispersed in a metal organic frame, and then calcination is performed in an inert atmosphere to successfully realize uniform dispersion of an Mn catalyst on a ZIF-8-derived nitrogen-doped dodecahedron carbon material to form the Mn-based multifunctional nano-enzyme. The optimal valence state proportion of Mn and the optimal manganese coordination structure are obtained by regulating and controlling the Mn doping amount, the carbonization temperature and the like, so that the Mn-based multifunctional nano-enzyme with good UOD, CAT and SOD performance is obtained, and the purposes of rapidly reducing uric acid and hydrogen peroxide and eliminating inflammation are achieved.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI

Bacterial strain with purine reducing function and application thereof

The invention belongs to the technical field of functional microorganism screening and application, and particularly relates to a strain with a purine reducing function and application thereof. The lactococcus lactis AMCC 11671 (Lactococcus lactis AMCC 11671) provided by the invention is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number of the lactococcus lactis AMCC 11671 is CCTCC NO: M 2024078. The lactococcus lactis AMCC 11671 provided by the invention has good crude enzyme activity, can effectively slow down the generation and accumulation of uric acid by reducing the purine content and degrading uric acid, has good tolerance to acid and cholate, has the ability to tolerate gastrointestinal tract environment, and has potential of colonization in human gastrointestinal tracts and play roles.
Owner:ANGEL YEAST (LIUZHOU) CO LTD +1

Lactobacillus paracasei with uric acid reducing function and application of lactobacillus paracasei

The invention discloses a Lactobacillus paracasei strain with a uric acid reducing function and application thereof, the Lactobacillus paracasei strain is named as Lactobacillus paracasei C125, and is preserved in China Center for Type Culture Collection on February 17, 2025, the preservation number is CCTCC M 2025231, and the preservation address is Wuhan University, Wuhan University, No. 299, eight road, Wuchang District, Wuhan City, Hubei Province. The fermentation supernatant of the casei paracasei has the functions of reducing uric acid, resisting oxidation and inhibiting bacteria, and has a wide application prospect.
Owner:YUNNAN AGRICULTURAL UNIVERSITY

Image recognition method and system for urinary system calculus

The invention relates to the technical field of medical image processing and intelligent diagnosis. The image recognition method for the urinary system calculus comprises the steps that a dynamic video stream of a calculus area is obtained through an endoscope image collection module, and a current frame image is extracted; performing illumination compensation processing on the image, eliminating vascular interference and light reflection, and enhancing the boundary of a calculus main body; based on multispectral feature fusion, separating yellow-like spectrum features of uric acid stones and grey-white-like spectrum features of calcium stones, and calculating stone surface color distribution dispersion; performing multi-angle texture energy detection by adopting a direction sensitive convolution kernel to generate a calcification crystallization density coefficient; inputting the color distribution dispersion and the calcification crystallization density coefficient into a decision tree model, and outputting a calculus type identifier; and according to the stone type identifier and the three-dimensional projection area of the stone contour, frequency-energy combination parameters of the laser stone crusher are generated, and the laser pulse emission time sequence is controlled in real time.
Owner:SCIVITA MEDICAL TECHNOLOGY CO LTD

Phellinus igniarius fermentation method for high-yield production of Hispidin and application of phellinus igniarius fermentation method

The invention relates to the technical field of fermentation of edible and medicinal fungi, and discloses a phellinus igniarius fermentation method capable of producing high-yield Hispidin and an application of the phellinus igniarius fermentation method. The phellinus igniarius fermentation method comprises the following steps: inoculating a phellinus igniarius strain into a culture medium containing a copper ion compound, and fermenting. The phellinus igniarius mycelium obtained by adopting the fermentation method is rich in Hispidin, and can be widely used for preparing related medicines and health foods for protecting liver, resisting tumors, resisting viruses, resisting oxidation, reducing uric acid and the like. In addition, the invention also discloses a high performance liquid chromatography detection method for analyzing the content of Hispidin, by adopting the method, the content of Hispidin and precursor substances (such as protocatechuic acid, protocatechualdehyde, caffeic acid, osmundone and the like) in the phellinus igniarius leavening and derivative products thereof as well as phellinus igniarius mycelia can be effectively analyzed, and the accuracy of Hispidin detection is favorably improved.
Owner:HUNAN UNIV OF CHINESE MEDICINE

Uric acid-reducing apigenin cyclodextrin inclusion compound liposome and preparation method thereof

The invention discloses a uric acid reducing apigenin cyclodextrin inclusion compound liposome and a preparation method thereof. The uric acid reducing apigenin cyclodextrin inclusion compound liposome is prepared from the following components in parts by weight: 1 part of apigenin, 2 to 50 parts of beta-cyclodextrin, 0.8 to 30 parts of phospholipid and 0.1 to 10 parts of surfactant. According to the invention, apigenin is included in beta-cyclodextrin to obtain the apigenin cyclodextrin inclusion compound, and the water solubility of apigenin can be improved and the molecular volume can be increased through a cyclodextrin inclusion method to reduce the ability of apigenin to penetrate through a phospholipid bilayer; and the apigenin cyclodextrin inclusion compound is encapsulated in the liposome to obtain the apigenin cyclodextrin inclusion compound liposome, so that the stability of the liposome is fundamentally improved, and the problem of liposome drug leakage in a liquid state is solved. The whole water solubility of the apigenin cyclodextrin inclusion compound liposome provided by the invention is improved, the apigenin cyclodextrin inclusion compound liposome has good stability and slow release effect, the bioavailability of apigenin is improved, and the uric acid reducing effect is obviously superior to that of untreated apigenin.
Owner:XIAN NUOZHONGKANGJIAN BIOTECHNOLOGY CO LTD

Camel milk polypeptide with xanthine oxidase inhibitory activity and application thereof

The invention discloses camel milk polypeptide with xanthine oxidase inhibitory activity and application thereof.The camel milk polypeptide is prepared by taking fresh camel milk as a raw material, conducting low-temperature centrifugation to remove fat, conducting triple enzymolysis through papain, pepsin and trypsin to obtain enzymatic hydrolysate, enabling the enzymatic hydrolysate to pass through an ultrafiltration membrane (the molecular weight cutoff is 10 kDa) to obtain filtrate, and conducting freeze-drying to obtain the camel milk polypeptide. The compound has xanthine oxidase inhibitory activity. The invention also discloses a small molecule polypeptide with xanthine oxidase inhibitory activity. The filtered solution is screened and combined with polypeptides by adopting a xanthine oxidase affinity ultrafiltration method, the activity of the polypeptides is verified through molecular docking and in-vitro enzyme inhibition, four small-molecule polypeptides with xanthine oxidase inhibitory activity are obtained, the sequence of the small-molecule polypeptides is shown as any one of SEQ ID NO.1-4, and the small-molecule polypeptides can be used for preparing drugs with the effect of inhibiting the uric acid level.
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY

Wearable multifunctional health monitoring equipment based on carbon nanotube enhanced electrochemical platform and preparation method of wearable multifunctional health monitoring equipment

The invention discloses a sweat uric acid and glucose sensor based on a carbon nanotube (CNT) enhanced electrochemical platform, and aims to solve the sensitivity challenge of low-concentration biomarker detection in sweat. The enzyme is covalently immobilized on the CNT through an EDC / NHS chemical method, so that the catalytic efficiency, the electron transfer speed and the sensor stability are remarkably improved, and the ultralow detection lower limit of uric acid and glucose is realized. According to the device, uric acid, glucose and pH sensing functions are integrated on a single wearable platform, efficient flowing and rapid updating of sweat are ensured through a radiation symmetry microfluid design optimized through finite element analysis, and real-time biomarker monitoring is supported. The material innovation (such as CNT-enzyme complex) and fluid dynamics optimization of the invention overcome the key problem in the field of wearable biosensing, and provide an extensible solution for the next generation of non-invasive health monitoring.
Owner:SHANGHAI UNIV

Rice residue oligopeptide and application thereof in reducing uric acid

The invention belongs to the technical field of biochemistry, and particularly relates to a rice residue oligopeptide and application thereof in reducing uric acid, and the amino acid sequence of the rice residue oligopeptide is any one of SEQ ID NO: 3, SEQ ID NO: 9 and SEQ ID NO: 10. The rice residue oligopeptide can realize multi-target simultaneous intervention of multiple links of uric acid metabolism, has the characteristics of inhibiting uric acid generation, promoting uric acid excretion and resisting oxidation, can realize an excellent uric acid reducing effect, and provides a further theoretical basis for deep development of rice processing byproducts.
Owner:CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY +1

Preparation method and application of medicinal and edible composition for reducing uric acid and treating gout

The invention discloses a preparation method and application of a medicinal and edible composition for reducing uric acid and treating gout, and belongs to the crossing field of medicine and food technologies. The composition is composed of celery seeds, sophora flower buds, chicory, dandelion, mulberry twigs, pawpaw and fresh lalang grass rhizomes, all the components have a synergistic effect, and the effects of inhibiting generation of uric acid, promoting excretion of uric acid, resisting inflammation, diminishing swelling and adjusting body metabolism at multiple target points are achieved. The preparation method comprises the steps of intelligent screening and fine pretreatment of raw materials, a multi-stage targeted extraction process and intelligent concentration and precise forming, and active ingredients can be efficiently extracted and prepared into various dosage forms. According to the composition, in the aspect of precise medical assistance, personalized medication schemes are customized according to different stages of gout, and whole-course digital management is achieved by means of intelligent equipment and a cloud platform; in daily smart health care of families, gout prevention of the families is facilitated through smart home kitchen equipment and a uric acid monitoring set; the method is used for innovative health food development, and provides a new natural, efficient and multifunctional health management approach for gout patients.
Owner:SHANDONG RENYITANG BIOTECHNOLOGY CO LTD

Weissella sinus X1 with functions of regulating metabolism and reducing uric acid and application of Weissella sinus X1

The invention discloses a Weissella cibaria X1 strain with functions of regulating metabolism and reducing uric acid and an application of the Weissella cibaria X1 strain. 49 lactic acid bacteria are screened from samples of fermented vegetables, healthy human body oral cavities and piglet feces, and 10 lactic acid bacteria are screened through PCA analysis on the basis of metabolism regulation and obesity inhibition ability; the method comprises the following steps: carrying out safety evaluation and uric acid reduction capability evaluation on 10 strains, finally screening out a strain X1, and identifying that the strain X1 is Weissella cibaria; the X1 strain and metabolites thereof have the function of reducing uric acid, excretion of uric acid can be promoted by adjusting expression levels of OAT1, UOX and HNF4A in vivo, expression of HPRT is adjusted to prevent excessive generation of uric acid and further reduce the level of uric acid, and a new way is provided for developing a uric acid reducing method without side effects.
Owner:BOHAI UNIV

Thermal inactivation substance bifidobacterium subsp. Lactis metaplasm as well as preparation method and application thereof

The preparation method comprises the following steps: centrifuging an activated culture solution of animal bifidobacterium subsp. Lactis HNU212 to remove a supernatant, washing with 0.9% normal saline, adjusting the strain concentration to 1 * 10 < 9 > CFU / mL, and inactivating at 90 DEG C for 15 minutes, thereby obtaining the thermal inactivation bifidobacterium subsp. Lactis metagen. The invention also provides a preparation method of the thermal inactivation bifidobacterium subsp. Lactis metagen, and the preparation method of the thermal inactivation bifidobacterium subsp. Lactis metagen comprises the following steps of: preparing the thermal inactivation bifidobacterium subsp. Lactis metagen and the preparation method of the thermal inactivation bifidobacterium subsp. Lactis metagen. When applied to an HUA animal model, the thermal inactivation substance bifidobacterium subsp. Lactis metaplasm prepared by the invention can effectively reduce the serum uric acid level, relieve kidney and intestinal injury and regulate host intestinal flora, and has the effect of relieving and treating HUA.
Owner:HAINAN UNIV

Method for preparing diglyceride for reducing uric acid through enzymolysis as well as product and application of diglyceride

The invention discloses a method for preparing uric acid-reducing diglyceride through enzymolysis and a product and application thereof, and belongs to the technical field of diglyceride production, the method comprises the following steps: (1) mixing vegetable oil, glycerol, water and an enzyme preparation for reaction to obtain a reaction solution; (2) standing and layering the reaction liquid, and collecting supernatant; (3) performing distillation separation on the supernatant, and performing decoloration and deodorization to obtain diglyceride; the enzyme preparation in the step (1) is prepared from lipase Lipase, esterase Esterase and phospholipase C in a weight ratio of (5-10): (0.1-0.3): 1. Compared with the prior art, the method disclosed by the invention is simple and low in cost, and the prepared diglyceride has more advantages in the aspect of reducing uric acid.
Owner:广东善百年特医食品有限公司

Abdominal distention hippocampal peptide and application thereof in preparation of uric acid reducing and gout resisting products

The invention relates to the field of preparation and application of biological peptides, in particular to a swelling hippocampal peptide and application thereof in preparation of uric acid reducing and gout resisting products. The amino acid sequence is shown as SEQ ID NO.1-5. The uric acid reducing effect is verified by adopting an in-vitro XOD inhibition experiment and a cell experiment; furthermore, the uric acid reducing and gout resisting activity of the compound is verified through a hyperuricemia animal model, and a theoretical basis is provided for high-valued utilization of the belly-swelling hippocampus and development of uric acid reducing and gout resisting products.
Owner:OCEAN UNIV OF CHINA

Application of xanthohumol in preparation of drugs for reducing uric acid and resisting gout

The invention relates to the technical field of medicines, in particular to application of an active ingredient xanthohumol (XAN) derived from a traditional Chinese medicine humulus lupulus in preparation of medicines for reducing uric acid and resisting gout, and the xanthohumol (XAN) can be prepared into various oral preparations, injection preparations and external preparations with the assistance of pharmaceutically acceptable auxiliary materials and has good development and application prospects. The inventor finds that the xanthohumol has relatively strong effects of reducing blood uric acid, resisting inflammation, resisting bone damage and the like, and the mechanism of the effect of reducing the blood uric acid is that the activity of xanthine oxidase is inhibited so as to reduce the generation of uric acid, and the renal function of an organism is improved so as to enhance uric acid excretion; according to the anti-inflammatory effect, the inflammatory reaction is relieved mainly by down-regulating the levels of inflammatory factors such as IL-1beta, IL-6, TNF alpha and PEG2; the mechanism for resisting gout bone damage is realized through the fact that RANKL / OPG / RANK signal pathway participates in bone metabolism regulation.
Owner:THE NAVAL MEDICAL UNIV OF PLA

Separation device and separation method for traditional Chinese medicine formula medicinal materials for reducing uric acid

The invention discloses a separation device and a separation method for traditional Chinese medicine formula medicinal materials for reducing uric acid, and relates to the technical field of medicinal material separation.The separation device comprises an equipment body, a bottom plate is fixedly arranged at the bottom of the equipment body, a spraying mechanism is arranged on the equipment body, and a cleaning position switching mechanism is arranged above the bottom plate; the cleaning position switching mechanism can move the cleaned medicinal materials out of the interior of the equipment body and place the medicinal materials to be cleaned at the cleaning position in the equipment body. The problems that in the prior art, when traditional Chinese medicinal materials are cleaned in batches, an operator needs to manually place a part of the medicinal materials into cleaning equipment and take out the medicinal materials after treatment is completed, a lower filter plate needs to be operated after the whole cleaning task is completed, and if the cleaning task consumes a long time, the cleaning efficiency is high are solved. The lower filter plate may accumulate a large amount of impurities due to the fact that the lower filter plate is not cleaned in time for a long time.
Owner:ANHUI BENCAO FANGTANG HEALTH IND CO LTD

Quaternary ammonium salt modification-based MXene non-enzymatic uric acid electrochemical sensor, method and application

The invention discloses a non-enzymatic uric acid electrochemical sensor based on quaternary ammonium salt modified MXene, a method and application, and belongs to the technical field of sensors. The preparation method comprises the following steps: preparing an MXene material through an etching method; the preparation method comprises the following steps: modifying an MXene material by adopting quaternary ammonium salt to obtain a modified MXene material; a working electrode is modified with the modified MXene material, a reference electrode and a counter electrode are combined to form a three-electrode system, and the non-enzymatic uric acid electrochemical sensor based on quaternary ammonium salt modified MXene is obtained. The prepared non-enzymatic uric acid electrochemical sensor is excellent in performance, high in sensitivity and low in detection limit; the linear range is wide and covers the human blood uric acid concentration range; the stability is good, and the influence by temperature and pH is avoided; the biological compatibility is good, the antibacterial property is good, and the toxicity is low. The sensor can realize rapid and quantitative detection of human blood uric acid concentration, has excellent detection performance, and has no obvious difference with the detection result of a large biochemical analysis instrument.
Owner:ZHEJIANG UNIV

Acne removing essence and preparation method thereof

The invention discloses an acne-removing essence and a preparation method thereof, and particularly relates to the technical field of skin care products, the acne-removing essence comprises the following components by mass: 0.5-5% of salicylic acid; 1%-5% of tartaric acid; 2%-6% of nicotinamide; 0.5%-2% of colloidal sulfur; 1.5%-3% of tea tree essential oil; 1%-2% of hyaluronic acid; 0.5%-1% of ceramide; 1%-3% of glycerol; 1%-2% of trehalose; the salicylic acid is used for penetrating into skin, helping to relieve dead skin cells, reducing inflammation and accelerating skin renewal; the tartaric acid is used for realizing a stripping effect, can remove aged cuticles on the surface of the skin and promote the generation of new cells, so that the problem of acnes is helped to be improved. The acne-removing essence prepared by the invention has a relatively good moisturizing effect, so that skin barrier can be well maintained, keratin metabolism is promoted, grease secretion is inhibited, acne is effectively prevented, inflammatory response of the acne is relieved, and the actual use effect of the acne-removing essence is relatively good.
Owner:GUANGZHOU YOUYANG COSMETICS CO LTD

Molecularly imprinted electrochemical sensor for hippuric acid detection, preparation method and segmented response technology

The invention provides a molecularly imprinted electrochemical sensor for hippuric acid detection, a preparation method and a segmented response technology, and belongs to the technical field of electrochemical sensors. Based on functional monomers aniline and o-phenylenediamine, hippuric acid is taken as a template molecule, and the molecularly imprinted electrochemical sensor for detecting hippuric acid is prepared by an electrochemical polymerization method, and combines the advantages of a molecular imprinting technology and an electrochemical technology; the hippuric acid detection sensor has excellent sensitivity, fast response time and specific recognition capability, has good signal response to hippuric acid detection under different concentrations, generates a good electric signal in a hippuric acid solution of 0-100 nM, forms a better linear relationship between the electric signal generated in the hippuric acid solution with the concentration of 100 nM or above and the concentration, and can be applied to the detection of hippuric acid with the concentration of 100 nM or above. The signal response and detection range of the molecularly imprinted electrochemical sensor under high concentration is widened, and the molecularly imprinted electrochemical sensor is suitable for hippuric acid detection in a wide range.
Owner:TIANJIN UNIV

Uric acid data acquisition and anomaly detection method and device based on multi-modal fusion

The embodiment of the invention discloses a uric acid data acquisition and anomaly detection method and device based on multi-modal fusion. A specific embodiment of the method comprises the following steps: controlling a medical data query end to query a historical uric acid detection data set corresponding to uric acid detail retrieval information; performing image enhancement processing on the initial uric acid detection image according to a pre-trained uric acid detection image enhancement model to generate an enhanced uric acid detection image; performing uric acid area identification on the enhanced uric acid detection image to obtain a uric acid identification area image group; optimizing each uric acid recognition area image in the uric acid recognition area image group to generate an optimized uric acid recognition area image, and obtaining an optimized uric acid recognition area image group; and inputting the historical uric acid detection data set and the optimized uric acid recognition area image group into a pre-trained multi-mode uric acid anomaly detection model to generate a uric acid anomaly detection result. According to the embodiment, the detection accuracy is improved, and accurate dynamic detection of uric acid abnormity is realized.
Owner:MACKEREL (BEIJING) NETWORK TECHNOLOGY CO LTD

Composite quality control liquid for electrochemical multi-parameter detector

The invention provides a composite quality control liquid for an electrochemical multi-parameter detector. The composite quality control liquid comprises a buffer volume, a quality control substance and a stabilizer, the stabilizing agent comprises 5 to 50 g / L of bovine serum albumin, 0.1 to 10 g / L of EDTA-2Na (Ethylene Diamine Tetraacetic Acid), 10 to 100 g / L of a viscosity regulator, 0.3 to 25 g / L of a preservative and 5 to 20 g / L of a surfactant; the preparation method comprises the following steps: adding components of the stabilizer into a buffer system, preparing a preparation solution, preparing mother liquor of each quality control substance, proportionally mixing glucose mother liquor, uric acid mother liquor, beta-hydroxybutyric acid mother liquor and cholesterol sodium sulfate and triglyceride composite mother liquor according to the target concentration of the quality control solution, and fixing the volume by using the preparation solution to obtain the quality control liquid. And fully and uniformly mixing to obtain the composite quality control liquid. The composite quality control liquid can ensure that uric acid is not degraded, cholesterol triglyceride is not separated out, the formula is mild, and active substances in a detection system are not influenced.
Owner:HEFEI JUXUANMIAN HEALTH TECH CO LTD

Uric acid reducing probiotics based on rapid and high-throughput screening of bombyx mori and application of uric acid reducing probiotics

The invention relates to uric acid reducing probiotics obtained by high-throughput screening based on a silkworm model, in particular to a strain SWU-MY69, which is classified and named as Pediococcus pentosaceus, is preserved in China General Microbiological Culture Collection Center (CGMCC), has a preservation number of CGMCC No.31926, and is preserved in September 10, 2024. The pediococcus pentosaceus SWU-MY69 screened through a bombyx mori model has an excellent uric acid reducing effect, the inhibition rates of bacterial suspension, contents and metabolites of the strain on xanthine oxidase in vitro are all 80% or above, and the pediococcus pentosaceus SWU-MY69 also has an excellent inhibition effect on xanthine oxidase in vivo; uric acid in hemolymph is remarkably reduced, excretion of uric acid by intestinal tracts is promoted, and therefore the concentration of uric acid in serum is reduced, and burdens of kidneys and livers are reduced.
Owner:SOUTHWEST UNIV