173results about How to "Inhibitory activity" patented technology

The utility model discloses a rapid centrifugal separation device for nucleic acid extraction and relates to the technical field of nucleic acid extraction and separation equipment. The clamping device comprises a machine body and a driving assembly, a limiting disc is fixedly arranged at the top end of a bottom plate, positioning assemblies distributed in an array mode are fixedly arranged at the top end of the driving assembly, each positioning assembly comprises an external sliding way, the external sliding ways are fixedly installed at the top end of the bottom plate, clamping blocks distributed symmetrically are movably inserted into the external sliding ways, and a threaded rod is rotationally arranged at the top end of the bottom plate; the outer side of the threaded rod is sleeved with three threaded sliding blocks in a threaded mode, connecting plates are fixedly arranged at the two ends of each threaded sliding block respectively, and inclined plates which are symmetrically distributed are fixedly arranged on the outer sides of the connecting plates. According to the centrifugal tube clamping and positioning device, the machine body, the external sliding way, the clamping block, the threaded rod, the threaded sliding block, the connecting plate, the inclined plate and other structures are arranged to be matched with one another, centrifugal tubes of different specifications can be clamped and positioned, and therefore centrifugal separation can be conveniently conducted on the centrifugal tubes of different specifications, and the use range of the device can be widened.

This invention discloses a flue gas denitrification device and method for thermal power plants. The flue gas denitrification device includes: a primary cyclone separator, a secondary electrostatic precipitator, a denitrification tower, a steam heating assembly, and a control module. The secondary electrostatic precipitator is located downstream of the primary cyclone separator in the flue gas flow direction. The denitrification tower is connected to the secondary electrostatic precipitator via a conveying pipe. One end of the conveying pipe is connected to the outlet of the secondary electrostatic precipitator, and the other end is connected to the inlet of the denitrification tower. A temperature sensor is installed on the conveying pipe. The steam heating assembly is used to introduce steam into the conveying pipe. According to this invention, the flue gas denitrification device for thermal power plants effectively removes large and fine dust particles, eliminates the risk of dust clogging and poisoning of the denitrification catalyst, improves the uniformity and efficiency of the denitrification reaction, and avoids dust clogging of the atomizing nozzles, thereby improving denitrification efficiency.

The application provides a preparation method of a diphenylfluorene polyether. The method uses diphenylfluorene as a substrate, butylene oxide as an epoxide monomer, toluene as an organic solvent, and under the action of a composite catalyst, reacts at 110-200 DEG C for 2-6 hours to obtain the diphenylfluorene polyether. The composite catalyst is obtained by reacting a porous aromatic skeleton with a bromoalkyl quaternary ammonium salt to obtain a quaternary ammonium salt functionalized porous aromatic skeleton, and finally, a basic catalyst is limitedly encapsulated in the pore channel of the quaternary ammonium salt functionalized porous aromatic skeleton by electrostatic attraction. The catalyst of the method can be recycled and reused, and the yield retention rate is greater than or equal to 92% after the composite catalyst is used for 5 cycles, and the method is suitable for optical display, high-frequency circuit board, semiconductor packaging and other fields.

The application discloses a compound fertilizer for promoting cotton high yield and a preparation method thereof, relates to the technical field of cotton fertilizer, and comprises first mother liquor A, second mother liquor B and third mother liquor C which are prepared, stored and packaged separately; the first mother liquor A contains urea phosphate, monoammonium phosphate, anhydrous citric acid, malic acid and manganese sulfate monohydrate; the second mother liquor B contains commercial 11-37-0 liquid ammonium polyphosphate, ammonium salt type polyaspartic acid solution, purified fulvic acid clear liquid and tri-potassium citrate; and the third mother liquor C is a mixed system of polyol complex state boron clear pre-liquid and medium complex state zinc pre-liquid. The application can improve the effective state stability of phosphorus, zinc and boron, reduce the risks of precipitation fouling and dripping head blockage, alleviate the risks of local salt peak and root injury in the seedling stage, promote the uniform emergence and young root growth of cotton, and improve the yield.

The invention discloses an application of samidocardone in preparation of a medicine for treating pulmonary fibrosis. According to the application disclosed by the invention, the condition that the samidojun can inhibit the activity of the pulmonary fibrosis cells and reduce proliferation by inducing the ferroptosis of the pulmonary fibrosis cells is proposed and verified for the first time, and meanwhile, the expression of fibrosis-related proteins is reduced, so that the progress of the pulmonary fibrosis is effectively relieved, and a new direction is provided for treating the pulmonary fibrosis.

The application provides a method for inducing poly-podophylli rhizoma by using clump buds, comprising the following steps: S1, cutting stem segments from a podophylli rhizoma mother plant, soaking and cleaning to obtain explants; S2, disinfecting and cleaning the explants, inoculating into a clump bud induction medium to obtain podophylli rhizoma clump buds; S3, inoculating the clump buds into doubling liquid I, washing with a liquid clump bud induction medium after culture, and then transferring into doubling liquid II; S4, taking out the clump buds, cleaning, inoculating into a clump bud induction medium, and then inoculating into a bud proliferation medium; S5, waiting until 1-2 cm, screening out potential mutant strains through phenotypes, inoculating into the bud proliferation medium for subculture, and obtaining mutant plants; and S6, rooting culture of the mutant plants, and after root systems grow, planting and raising seedlings, and then poly-podophylli rhizoma plants are obtained. In the research, suitable concentration of colchicine is used for induction treatment twice, and through stage concentration switching and intermittent recovery strategies, the poly-ploid induction efficiency and explant survival are effectively considered.

The application discloses an inhibitor for inhibiting KRAS phase separation to play an anti-tumor role and application, and relates to the fields of tumor molecular biology and targeted therapy.The application aims at solving the problems of limited effect, strong drug resistance and limited application range of KRAS tumor treatment methods, and the inhibitor is a statin.The KRAS protein can form a liquid condensate in cells, and the application discloses the mechanism of the KRAS protein in promoting KRAS protein processing, transportation and downstream signal activation, and further provides a technical scheme for inhibiting tumor growth and enhancing the therapeutic effect of a KRAS inhibitor by inhibiting the formation of KRAS condensates, so as to provide a new target and intervention approach for tumor treatment.

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.

This invention discloses 5α-reductase degrading molecules, their preparation methods, and applications. Four 5α-reductase degrading molecules can induce proteasome-dependent degradation of 5α-reductase, achieving complete clearance of the enzyme protein rather than merely inhibiting its activity, thus obtaining a more durable therapeutic effect. Under equal-dose conditions, the 5α-reductase degrading molecules are more effective than the traditional inhibitor finasteride in treating benign prostatic hyperplasia (BPH). These four 5α-reductase degrading molecules can effectively degrade 5α-reductase protein and significantly inhibit the development of BPH, exhibiting good biocompatibility. This provides a new strategy and candidate drugs for the treatment of BPH, prostate cancer, androgenetic alopecia, acne, and other diseases related to 5α-reductase.

The invention relates to the technical field of automobile parts, and particularly discloses an anti-oxidation corrosion-resistant automobile air-inlet grille and an electroplating process thereof.The anti-oxidation corrosion-resistant automobile air-inlet grille is prepared from phenoxy-terminated siloxane modified polycarbonate, ABS resin, a modified LDHs antioxidant, a compatilizer ABS-g-MAH and a lubricant ethylene bis stearamide through melt blending, extrusion granulation and injection molding. And a copper layer, a nickel-phosphorus layer and a cobalt-chromium layer are further electroplated and deposited on the automobile air-inlet grille, and the anti-oxidation and corrosion-resistant automobile air-inlet grille is formed.

The present application relates to the chemical medicine field, specifically, it relates to a kind of anti-tumor calophyllol derivative, preparation method and application, the calophyllol derivative has good inhibitory effect on thioredoxin reductase activity, and it is found that the molecule inhibits the activity of thioredoxin reductase by inhibiting the selenium cysteine of thioredoxin reductase carbon end, and then kills tumor cell, and then obtain the anti-tumor candidate drug with higher activity and better pharmacokinetic characteristics.

The utility model belongs to the field of electrical equipment control operation cabinets, particularly relates to an electrical equipment automatic control operation cabinet based on a PLC, and aims to solve the problems that dust and impurities fall down and are easily sucked into an operation cabinet to pollute the operation cabinet due to the fact that an existing filter screen is vibrated during replacement and disassembly. Comprising an operation cabinet body, a mounting opening is formed in the top of the operation cabinet body, a cooling fan is fixedly mounted in the mounting opening, and air inlet mechanisms are arranged on the two sides of the operation cabinet body; the air inlet mechanism comprises an air pipe, the air pipe penetrates through one side of the operation cabinet body in a sliding mode, and one end of the air pipe is fixedly connected with a back plate. Dust falling from the filter screen is prevented from being sucked into the operation cabinet body when the filter screen is replaced, the cleanliness of the interior of the operation cabinet body when the filter screen is replaced is improved, and the service life of the operation cabinet body is prolonged. And meanwhile, the limiting frame can be blocked through the anti-disassembly plate, the situation that the filter screen is replaced when the air pipe is not pulled out is prevented, and non-standard operation is avoided.

The application discloses a whitening and freckle-removing composition containing white tomato and chases yellow grass, a preparation method and application thereof, and belongs to the technical field of food, wherein the whitening and freckle-removing composition is composed of white tomato powder and chases yellow grass powder with a weight ratio of 1-3:2-7. The preparation method comprises the following steps: (1) beating, separating, concentrating and drying white tomatoes to obtain white tomato powder; (2) soaking chases yellow grass in acidic water, performing solid-liquid separation, concentrating and drying the obtained clear liquid to obtain chases yellow grass powder; and (3) mixing the white tomato powder and the chases yellow grass powder. The application utilizes the combination of white tomatoes and chases yellow grass, and improves the preparation process of chases yellow grass, so that the two components produce a synergistic effect in inhibiting tyrosinase activity and inhibiting melanin production.

The utility model discloses a kind of sauerkraut fermentation devices of quick dish, it is related to sauerkraut fermentation technical field, including fermentation tank, the feed pipe of fermentation tank top intercommunication, still include pressure detection component, pressure detection component includes the connecting piece connected in the inner wall of fermentation tank, elastic diaphragm is rotatably connected in the bottom of connecting piece, elastic diaphragm top is connected with top rod, and top rod is slidably connected on fermentation tank, pressure relief component, pressure relief component includes the support rod connected in the top of fermentation tank, the rotating shaft of support rod top rotatable connection, rotating shaft top is connected with driving plate, and driving plate bottom is connected with connecting rod, and connecting rod bottom is connected with baffle, and relief port is set on fermentation tank, by setting pressure detection component, the pressure inside can be detected in real time, and by pressure relief component timely discharge, ensure production efficiency.

This utility model relates to the field of paint baking lamp technology and discloses a quick-release portable paint baking lamp, including a shell. Four movable wheels are fixedly installed at the bottom corners of the shell, and a storage groove is provided on the top of the shell, with a fixing plate disposed in the storage groove. This utility model secures the connecting block by fully engaging it with a locking block. At this point, the limiting groove aligns with the limiting block, and a first spring pushes the limiting block out, causing its top to engage with the limiting groove, thus limiting the connecting block and preventing it from moving on the locking block. For disassembly, simply push the connecting block towards one side of the locking block to separate it from the locking block. This achieves tool-free assembly and disassembly of the paint baking lamp, which is very convenient. Folding the connecting rod between the connecting frames and then reversing the rotating rod allows the connecting frame to be stored in the storage groove, and the fixing plate is also stored in the storage groove along with the connecting frame, thus achieving quick storage and easy portability.

The utility model relates to a plate making machine sewage discharge technical field especially relates to a plate making machine wastewater treatment system, include: first -level processing mechanism, second -level processing mechanism, third -level processing mechanism, fourth -level processing mechanism and developing waste liquid processing mechanism, the import end of first -level processing mechanism is linked together with the discharge port of plate making machine ordinary sewage, the import end of second -level processing mechanism is linked together with the export end of first -level processing mechanism, the import end of third -level processing mechanism is linked together with the export end of second -level processing mechanism, the import end of fourth -level processing mechanism is linked together with the first export end of third -level processing mechanism, the first import end of developing waste liquid processing mechanism is linked together with the discharge port of plate making machine developing waste liquid. The utility model discloses through to the developing waste liquid of plate making machine and ordinary sewage separation carries out the treatment, can avoid high concentration pollutant to inhibit the activity of microorganism in ordinary sewage, can improve the processing efficiency and processing effect of plate making machine wastewater.

The invention discloses a rodlike carbon nitride-polydimethylsiloxane composite coating and a preparation method and application thereof.The rodlike carbon nitride-polydimethylsiloxane composite coating is prepared by mixing rodlike carbon nitride filler, polydimethylsiloxane and a curing agent, and even doping of the rodlike carbon nitride filler can effectively improve the crosslinking density of the composite coating; the adhesive force and the tensile strength of the coating are enhanced; when the composite coating is applied to the surface of a matrix, a multifunctional nano coating with mechanical reinforcement, long-acting corrosion prevention and microbial antifouling characteristics can be formed, the impedance arc radius is kept at 5.17 * 10 < 9 > omega.cm < 2 > after the composite coating is soaked for 60 days, and the composite coating shows excellent bacteriostasis and sterilization performance on chlorella and escherichia coli; the excellent biological pollution prevention characteristic is shown.

This invention discloses a method for the biological drying of sludge, comprising the following steps: baking biomass materials, mixing the resulting baked product with sludge, biochar materials, and a conditioner for biological drying, thereby completing the sludge drying process. In this invention, by biologically drying the mixture of baked product, sludge, biochar materials, and conditioner, not only can the self-generated heat within the system be used to effectively dewater the sludge in a very short time, but the bioavailability of the microbial carbon source can also be improved, effectively reducing the generation of polluting gases. This method can effectively reduce the emission of polluting gases while achieving rapid dewatering. It has advantages such as simple process, low treatment cost, low energy consumption, high drying efficiency, good dewatering effect, low polluting gas production, and low content of toxic and harmful components in the dried product. It can solve the problems of biomass resource waste and pollution, achieve sludge reduction and resource utilization, and has high returns and good application prospects.

The utility model discloses a kind of processing device of water body filter membrane fixed environmental microorganism DNA, including the pretreatment box of being equipped with several placing cavities and the collection box with refrigeration component in inner cavity, pre-treatment pipe is placed in placing cavity and placing cavity lower end is equipped with liquid outlet passage, refrigeration component upper side is connected with the metal containing body of being equipped with several containing cavities, containing cavity contains centrifuge tube, the assembly plate of being located centrifuge tube upper side is covered on the upper end cover of collection box, assembly plate includes the assembly hole of being connected with the liquid outlet passage and centrifuge tube and the fixing column in assembly hole inner cavity, fixing column is fixedly connected with the stainless steel needle that can penetrate liquid outlet passage and pre-treatment pipe.The utility model can synchronously process multiple samples at a time, shorten the processing time of batch samples, improve the processing efficiency and collection efficiency of microorganism DNA sample, the temperature of centrifuge tube in containing cavity can be stably controlled at 4 ℃, realize the rapid, batch, stable processing of water body filter membrane fixed environmental microorganism DNA.

This utility model discloses a mixing agitator for a hydrogenation reactor, comprising a reactor body, multiple legs fixedly connected to the outer wall of the bottom of the reactor body, a top cover rotatably connected to the top of the reactor body, a feed pipe fixedly connected to the top of the top cover, a feed cover plate rotatably connected to the top of the feed pipe, a discharge pipe fixedly connected to the bottom of the reactor body, a discharge valve fixedly connected to the outer wall of the discharge pipe, a stirring mechanism installed on the inner wall of the reactor body, an aeration treatment mechanism installed on the top of the reactor body, and a foam elimination mechanism installed inside the reactor body. The air pump of this utility model's aeration treatment mechanism introduces hydrogen gas into the rotating shaft through the air inlet pipe, and sprays it out from the aeration pipe through the air guide hose. This, combined with the motor driving the rotating shaft and stirring rod of the stirring mechanism, causes the hydrogen gas to disperse into tiny bubbles. Simultaneously, a scraper removes material from the reactor wall, avoiding dead zones and improving the uniformity of the gas-liquid-solid three-phase mixing. The mass transfer coefficient is improved compared to traditional agitators.

A traditional Chinese medicine composition for inhibiting or reducing breast cancer cells comprises Euphorbia kansui, Paeonia lactiflora, Glycyrrhiza uralensis, Taraxacum mongolicum, Gardenia jasminoides, and Hordeum vulgare. The weight ratio of Euphorbia kansui, Paeonia lactiflora, Glycyrrhiza uralensis, Taraxacum mongolicum, Gardenia jasminoides, and Hordeum vulgare in the traditional Chinese medicine composition is 1-2:4-6:2-3:3-5:2-4:2-3. This traditional Chinese medicine composition is intended for the preparation of anticancer drugs. The composition is administered to breast cancer cells at an effective dose between 0.1 and 10 mg / ml for culturing. Cell experiments have confirmed that the traditional Chinese medicine composition exhibits inhibitory activity against breast cancer cells, thereby achieving the purpose of treating breast cancer symptoms or inhibiting breast cancer cell activity.

The invention discloses a bio-based deoxidized oil hydroisomerization and cracking catalyst, the bio-based deoxidized oil hydroisomerization and cracking catalyst comprises a modified SAPO-11 molecular sieve and an active metal, a preparation method of the modified SAPO-11 molecular sieve comprises the following steps: mixing a silicon source, an aluminum source, water, a co-metal and a template agent to obtain an initial gel, and carrying out a hydrothermal reaction, drying and roasting on the initial gel to obtain the modified SAPO-11 molecular sieve, the auxiliary metal is one or more of chromium, zirconium and copper. The catalyst is low in preparation cost and good in thermal stability.

The present application relates to a kind of phosphonic acid-benzenesulfonic acid double modified carbon microspheres and its preparation method and application, belong to oil field chemical field.The method includes: S1 with biomass as raw material preparation original carbon microspheres;S2 original carbon microspheres are pre-oxidized and activated, obtain activated carbon microspheres;S3 activated carbon microspheres are phosphonated grafting reaction;S4 last perform sulfonic group grafting reaction.The present application also provides the phosphonic acid-benzenesulfonic acid double modified carbon microspheres prepared by this method, and the application of the phosphonic acid-benzenesulfonic acid double modified carbon microspheres in the preparation of water-based drilling fluid.In this phosphonic acid-benzenesulfonic acid double modified carbon microspheres, phosphonic acid group and benzenesulfonic acid group are introduced into the surface of carbon microspheres by stable covalent interaction, not easy to fall off in high temperature and high salt environment, can improve the stability of material in high temperature condition, to ensure that modified carbon microspheres in downhole complex working condition Long-term effect, make drilling fluid system can simultaneously withstand high temperature and high calcium ion double test.

The invention belongs to the technical field of special medical food, and relates to application of common turnip in products for inhibiting gastrointestinal tract helicobacter pylori. The common turnip extract has the function of treating or preventing helicobacter pylori infection, has a good improvement effect on prevention and inhibition of gastroenteritis caused by helicobacter pylori, remarkably improves the function of a digestive system, and can be used for preventing and treating the gastroenteritis caused by the helicobacter pylori and preventing and treating the gastroenteritis caused by the helicobacter pylori. And support is provided for developing novel dietary nutrition supplements, functional foods, special medical foods and pharmaceutical compositions for inhibiting helicobacter pylori. The invention further discloses a synergistic effect of a medicinal and edible composition formed by combining the common turnip extract with extracts of clove, codonopsis pilosula, hericium erinaceus, fructus amomi and the like on inhibition of helicobacter pylori, and a greater effect of inhibiting the activity of the helicobacter pylori can be achieved. The novel product for inhibiting helicobacter pylori developed by the invention has both safety and effectiveness, and has a very good application prospect.

The invention discloses a chlorine-containing pyrolysis oil radial moving bed reaction adsorption dechlorination hydro-conversion method, and belongs to the technical field of chlorine-containing oil product hydrotreatment and refining. According to the method, chlorine-containing pyrolytic oil is sequentially subjected to fixed bed selective hydrogenation, radial moving bed reaction adsorption dechlorination and fixed bed deep hydrofining reactor treatment; the radial moving bed is filled with a core-shell structure reaction and adsorption integrated catalyst, the core is a hydrodechlorination active component, the shell mainly adopts zinc oxide to adsorb HCl and is fixed in situ, and meanwhile, online addition and discharge of the catalyst are realized through the radial moving bed. According to the invention, poisoning of chlorine to the catalyst is effectively inhibited, the corrosion risk of equipment is reduced, shutdown of the device is avoided, the dechlorination efficiency is improved, the continuous operation period is prolonged, efficient, stable and economical hydro-conversion of the chlorine-containing pyrolytic oil is realized, and the obtained product can be used as clean fuel oil or a chemical raw material.

The present invention relates to a specific binding protein targeting PD-L1 and CD73, wherein the specific binding protein is capable of specifically binding to PD-L1 and / or a fragment thereof, and CD73 and / or a fragment thereof. The present invention further relates to use of the specific binding protein in the treatment, prevention and / or diagnosis of diseases such as immune diseases, acute and chronic inflammatory diseases, and tumor diseases.

This invention provides a method for producing single-cell protein using a mixed bacterial culture, comprising the following steps: performing primary seed culture on methanogenic bacteria, *Tricholoma materata*, and *Glucosinolate methyl-eating bacteria* to obtain primary seed solutions; mixing the primary seed culture solutions evenly to obtain a mixed bacterial solution; inoculating the obtained mixed bacterial solution into a secondary seed culture medium for cultivation to obtain a secondary seed solution; inoculating the obtained secondary seed solution into a fermentation medium for scale-up cultivation to obtain a fermentation broth; separating the solid and liquid components of the obtained fermentation broth, harvesting the bacterial cells, and obtaining single-cell protein. This method for producing single-cell protein using a mixed bacterial culture improves the utilization rate of the carbon source methane and the yield of single-cell protein.

The utility model relates to the technical field of rust -proof spraying, concretely is the surface rust -proof coating of punch piece coating auxiliary structure, including cable, a plurality of hanger rods for hanging punch piece are installed on the cable, the bottom end horizontal of hanger rod is equipped with the hanger bar, and the hanger rod is installed with the resistance and pressure assembly, and the resistance and pressure assembly includes fixed seat, pressure lever and resistance block, and the fixed seat is equipped with resistance and pull assembly, and resistance and pull assembly includes movable rod and resistance lever. The surface rust -proof coating of punch piece coating auxiliary structure, through setting resistance and pressure assembly and resistance and pull assembly, can form two -way location to the punch piece that hangs on the hanger bar, avoid the punch piece and move along the hanger bar under the action of spraying pressure, and the swing of punch piece can be limited with the cooperation, make the position stable in the spraying process of punch piece, help to ensure that rust -proof coating is even, reduces the damage that the punch piece produces because of swing and collision simultaneously.