1182 results about "Gallic acid ester" patented technology

The invention provides modified acidic polysaccharide of lithocarpus litseifolius. The modified acidic polysaccharide is prepared from natural acidic polysaccharide of lithocarpus litseifolius through a chemical method or an enzyme method. Every 100 mg of the modified acidic polysaccharide of lithocarpus litseifolius contains 89.75 mg + / -1.04 mg to 90.67 mg + / -1.46 mg of total polysaccharide. The total uronic acid content is 23.70 mg + / -1.58 mg to 71.74 mg + / -2.07 mg; total bound phenol: 2.06 mg of GAE + / -0.06 mg of GAE-4.56 mg of GAE + / -0.04 mg of GAE (equivalent weight of gallic acid); the esterification degree is 3.72% + / -0.90% to 34.98% + / -0.62%; the molecular weight is (0.562 + / -0.012) * 10 < 4 > Da-(4.268 + / -0.055) * 10 < 4 > Da; the proportion of the galacturonic acid glycan (HG) is 15.28% to 65.02%; the ratio of the type I rhamnogalacturonan (RG-I) is 28.47% to 72.37%; and the length of a side chain is 0.44 to 10.31. The invention further provides a preparation method and application of the lithocarpus litseifolius modified acidic polysaccharide. The lithocarpus litseifolius modified acidic polysaccharide prepared by the invention has remarkable immunoregulatory activity, and especially has better immunocompetence when being used for removing arabinose side chains and reducing galactose side chains.

Hydrogel comprises hydroxyapatite nanowires and a base material for forming the hydrogel, and further comprises glucose oxidase (GOx), gallic acid, magnesium ions (Mg < 2 + >) and the like, the gallic acid and the Mg < 2 + > form Mg-MOF, and the GOx is loaded on the Mg-MOF, so that the diabetes microenvironment of a bone defect part is locally adjusted, and bone defect repair is facilitated. Through verification, the sustained-release gallic acid of GOx-MOF participates in cascade reaction, GOx is removed to generate H2O2, the benefit is maximized, and the sustained-release gallic acid has good effects of controlling blood glucose, removing ROS, regulating inflammation and promoting osteogenesis and angiogenesis. The research is expected to play a role in microenvironment regulation of diabetes mellitus bone regeneration and minimally invasive treatment of bone defects.

The invention provides a preparation method of a mixed pilatory of active peptide and stem cell exosome, and belongs to the technical field of pilatory preparation. The preparation method comprises the following steps: extracting the stem cell exosome; extracting an active extract; preparing an exosome entrapped active extract; preparing the liposome loaded active peptide; preparing the liposome loaded active peptide modified by the gallic acid modified chitosan; and preparing the mixed hair restorer. The prepared mixed hair restorer can provide a suitable growth environment for hair follicles and promote hair growth, the synergistic effect of the active peptide and the exosome can provide abundant signal molecules and enhance the stimulation effect on hair follicle cells, and the active peptide and the exosome can promote angiogenesis and increase the blood flow volume of scalp, so that the hair follicle can be effectively promoted. More nutrition and oxygen are provided for hair follicles, and the growth of hair is effectively promoted.

The invention provides a metal polyphenol nanoparticle, a preparation method thereof and an application of the metal polyphenol nanoparticle in preparation of a medicine for treating acute lung injury, the metal polyphenol nanoparticle is formed by self-assembly of metal ions and polyphenol, the metal ions are selected from Mg < 2 + >, Zn < 2 + >, Mn < 2 + > or Cu < 2 + >, and the polyphenol is selected from Mg < 2 + >, Zn < 2 + >, Mn < 2 + > or Cu < 2 + >. The polyphenol is selected from epigallocatechin gallate (EGCG), caffeic acid (CA), chlorogenic acid (CGA), gallic acid (GA) and luteolin (LUT). The metal polyphenol nanoparticles are used for preparing a medicine for treating acute lung injury induced by sepsis, pneumonia, serious trauma or inhalation injury, and the medicine further comprises a pharmaceutically acceptable carrier. The metal polyphenol nanoparticles provided by the invention are simple in preparation process and high in biological safety, polyphenol and metal ions synergistically enhance the anti-inflammatory and antioxidant activity, and the metal polyphenol nanoparticles are superior to the single use of polyphenol or metal ions.

The invention provides a long-acting rust converting agent for metal surfaces, and relates to the technical field of marine metal surface rust prevention and conversion, tannic acid, gallic acid and salicylic acid are matched with each other and can form a firm complex layer with formed metal oxide or metal through chelation, and the metal surface rust conversion effect is improved. The synergistic effect of the tannic acid corrosion inhibitor, the gallic acid corrosion inhibitor and the salicylic acid corrosion inhibitor enhances the exertion of the synergistic migration protection effect, a relatively compact and smooth conversion film can be formed on the rusted metal surface, the formed conversion film can effectively prevent a corrosion medium from permeating into the metal surface to make contact with the metal, and the metal corrosion inhibitor is suitable for steel structures, especially suitable for steel structure connecting parts and has good corrosion resistance and corrosion resistance. The rust remover has the advantages that the rust remover is good in permeability and high in rust conversion efficiency, harmful rust can be converted into a protective layer beneficial to corrosion prevention, effective protection is provided for a metal matrix, the corrosion prevention effect can reach 20 years or above, frequent maintenance is omitted, resources, manpower and material resources are saved, and remarkable economic benefits are achieved.

The invention belongs to the technical field of biological medicines, and particularly relates to hydrogel with photo-thermal multiple antibacterial and hemostatic functions. The multifunctional hydrogel is prepared from epsilon-polylysine (EPL), gallic acid (GA), tannic acid (TA) and ferric trichloride hexahydrate. The polyphenols are obtained through multiple mechanisms such as reaction between the polyphenols and amino groups, metal chelation, pi-pi interaction and electrostatic attraction (as shown in Figure 1). The metal ion and multiple dynamic cross-linking system hydrogel is constructed, the hydrogel with positive charges enriched on the surface can act with blood platelets with negative charges, red blood cell aggregation, blood platelet adhesion and vasoconstriction effects are promoted, and the blood coagulation efficiency is improved. The hydrogel shows excellent antibacterial performance and photo-thermal performance, can prevent infection in the inflammation stage of wound healing, can effectively accelerate wound healing, and has good biological safety.

The invention provides an acne-removing and relapse-preventing composition suitable for acne sensitive skin and application of the acne-removing and relapse-preventing composition, and belongs to the technical field of cosmetics. The epigallocatechin gallic acid glucoside, the brazilin, the roselle flower extract, the jujube bark extract, the linseed oil unsaponifiable matter and the guaiacol extract are selected as active ingredients of the acne-removing and relapse-preventing composition and interact with one another, growth of acne-related pathogenic bacteria can be rapidly inhibited, and the skin micro-ecology can be adjusted; skin inflammation in the whole process of acne is effectively inhibited, the effects of preventing and inhibiting inflammation are achieved, the skin barrier is effectively repaired, redness is reduced, meanwhile, the effect of adjusting skin grease balance is achieved, and acne recurrence is prevented; in addition, the acne-removing and relapse-preventing composition also has the effects of removing yellow gas, uniformizing skin color and improving skin roughness, is mild and non-irritating, can be used for sensitive skin, and expands the application range of the acne-removing and relapse-preventing composition.

The invention relates to the field of epoxy molding compounds, and discloses an epoxy molding compound as well as a preparation method and application thereof. The epoxy molding compound contains a heat-conducting filler, epoxy resin, a curing agent, a curing accelerator, a coupling agent, a bonding modifier, a flame retardant, a coloring agent, a release agent, hydroxyl-terminated silicone oil and a dispersing wetting agent. The heat-conducting filler contains aluminum oxide, crystalline silicon dioxide powder and molten spherical silicon dioxide powder; the bonding modifier is a triazole compound or a gallic acid compound; the weight ratio of the hydroxyl-terminated silicone oil to the heat-conducting filler to the bonding modifier is (1.5-4): (700-800): 1. The epoxy molding compound has the advantages of favorable molding process property, excellent heat-conducting property and high adhesive strength, and is suitable for being used as a packaging material of a fully-packaged power module.

The invention discloses antibacterial and antioxidant composite hydrogel as well as a preparation method and application thereof. The antibacterial and antioxidant composite hydrogel is hydrogel formed by interpenetrating and cross-linking zinc ion loaded hectorite, gallic acid grafted methacrylated gelatin and arginine grafted methacrylated chitosan, the preparation method comprises the following steps: by taking gelatin and chitosan with good biocompatibility as substrate materials, carrying out grafting modification to obtain gallic acid-methacrylated gelatin (gallic acid grafted methacrylated gelatin) and arginine-methacrylated chitosan (arginine grafted methacrylated chitosan); the preparation method comprises the following steps: firstly, preparing a hydrogel, then mixing the hydrogel with zinc-hectorite (hectorite loaded with zinc ions) to prepare a stock solution, carrying out photo-crosslinking to form the hydrogel, and the prepared hydrogel has good antibacterial property, oxidation resistance, biocompatibility and blood compatibility, and can promote cell growth and wound healing and reduce inflammatory response.

The invention belongs to the technical field of microorganisms, and particularly relates to pseudomonas monteilii BDLZ-3 and application thereof in relieving continuous cropping obstacles of crops. The invention discloses a strain of pseudomonas monteilii BDLZ-3, the preservation number of which is CGMCC (China General Microbiological Culture Collection Center) No.34349. The pseudomonas monteilii BDLZ-3 is separated and screened from the nature for the first time, phenolic acid autotoxic substances generated in the ginseng continuous cropping obstacle process can be efficiently degraded, the degradation rate of benzoic acid can reach 95.36%, various phenolic acids such as vanillic acid, cinnamic acid, palmitic acid and gallic acid can be effectively degraded, and the degradation spectrum is wide; when the pseudomonas monteilii BDLZ-3 is applied in a field, the content of benzoic acid in soil can be effectively reduced, meanwhile, the occurrence of ginseng root diseases can be controlled to a certain extent, the prevention and treatment effect reaches 41.23%, the growth indexes such as root length and root thickness are remarkably improved, and the yield increasing effect is achieved.

The invention discloses a silk protein-MXene composite film and a preparation method thereof. The silk protein-MXene composite film sequentially comprises a conductive surface layer, a porous response layer and a supporting bottom layer from top to bottom, the invention relates to the technical field of composite films. According to the fibroin-MXene composite film and the preparation method thereof, a three-layer gradient structure is formed by the conductive surface layer, the porous response layer and the supporting bottom layer, good conductivity and electromagnetic shielding effectiveness are ensured by utilizing oriented arrangement of MXene of the conductive surface layer, gallic acid and MXene form a hydrogen bond network, and nitrogen-doped carbon quantum dots coat the surface of MXene to form a physical barrier, so that the electromagnetic shielding effect is improved, and the electromagnetic shielding effect is improved. Through double oxidation resistance of gallic acid and nitrogen-doped carbon quantum dots, a sponge body structure formed by the porous response layer is matched to endow the composite film with high-sensitivity response to external stimulation, the supporting bottom layer is crosslinked by hexamethylene diisocyanate and enhanced by nanocellulose, the tensile strength is improved, and the tensile strength of the composite film is improved. And the contradiction between the mechanical property and the conductivity of the traditional composite film is effectively solved.

The invention provides a zirconium boride / graphene complex-phase wear-resistant and high-temperature-resistant ceramic material and a preparation method thereof, and belongs to the technical field of ceramics. The preparation method comprises the following steps: pretreating graphene, preparing titanium dioxide / graphene microspheres, modifying the titanium dioxide / graphene microspheres, functionalizing the titanium dioxide / graphene microspheres, preparing a ceramic mixture, molding and sintering. The step of functionalizing the titanium dioxide / graphene microspheres comprises the following steps: putting the modified titanium dioxide / graphene microspheres into xylene, adding bisphenol A epoxy resin and triphenylphosphine, raising the temperature, carrying out stirring reaction, filtering out, washing, putting into N, N-dimethylformamide, uniformly stirring, adding gallic acid and p-toluenesulfonic acid, and carrying out ultrasonic treatment to obtain the titanium dioxide / graphene microspheres. Raising the temperature for reaction, filtering, washing and drying after the reaction is finished, so as to prepare functionalized titanium dioxide / graphene microspheres; the prepared ceramic material is high in strength, good in wear resistance and excellent in high temperature resistance.

The invention discloses a natural eutectic solvent enhanced konjac glucomannan film as well as a preparation method and application thereof, and belongs to the technical field of food packaging. The konjac glucomannan film enhanced by the natural deep eutectic solvent, provided by the invention, comprises konjac glucomannan, the natural deep eutectic solvent and gallic acid modified MXene nanoparticles; the mass ratio of the konjac glucomannan to the natural eutectic solvent to the gallic acid modified MXene nanoparticles is (850 to 950) to (50 to 250) to (10 to 40). Through the synergistic effect of all the components, the defects that KGM is insufficient in intrinsic mechanical strength, weak in antibacterial and antioxidant performance and poor in moisture resistance are overcome, the comprehensive performance of the film is remarkably improved, and the film can be used for cold-chain packaging of high-value fresh food and has environment friendliness and functional practicability.

The invention belongs to the field of biomedical materials, and discloses a composite hydrogel dressing and application. The composite hydrogel dressing is prepared by the following steps: blending 4-aminophenylboronic acid grafted hyaluronic acid and gallic acid grafted collagen, adjusting the pH value, carrying out a cross-linking reaction to obtain a cross-linking product, and stirring and mixing the cross-linking product with a gallic acid reduced silver nanoparticle solution. The antibacterial and self-healing composite hydrogel dressing for promoting wound repair has proper adhesion, mechanical properties and free radical scavenging ability, and excellent antibacterial property, biocompatibility and self-healing ability.

The invention provides an ultra-high molecular weight polyethylene fiber resin composite material interface regulation composition which comprises the following components in parts by weight: 100 parts of ultra-high molecular weight polyethylene fiber, 12 parts of polyethylene, 0.6 part of a compatilizer, 0.03 part of an initiator, 2.5 parts of gallic acid, 1 part of tetraethylenepentamine and 5 parts of nano silicon dioxide. The compatilizer is used for melt grafting with polyethylene, and the initiator is used for initiating melt grafting of the compatilizer and polyethylene. The invention also provides a method for carrying out interface regulation and control by adopting the interface regulation and control composition and an ultra-high molecular weight polyethylene fiber resin composite material prepared by the method. The ultra-high molecular weight polyethylene fiber resin composite material obtained by carrying out interface regulation and control treatment on the ultra-high molecular weight polyethylene fiber resin composite material interface regulation and control composition has a good interface state, excellent mechanical properties and good impact resistance.

The invention relates to the field of coatings, and discloses a biomass-based oil-resistant coating and a preparation method thereof, the coating comprises an additive solution, a paraffin solution and gallic acid; the paraffin solution is obtained by dissolving paraffin in absolute ethyl alcohol; a preparation method of the additive solution comprises the following steps: mixing chitosan powder and an acetic acid aqueous solution to prepare a chitosan solution, ultrasonically dispersing functionalized montmorillonite in deionized water to prepare a suspension, then uniformly mixing the chitosan solution and the suspension, adding modified phytic acid prepared by grafting phytic acid and ethylene glycol diglycidyl ether, and stirring to react; the functional montmorillonite is prepared by modifying modified montmorillonite with titanium dioxide and zinc oxide, then activating the modified montmorillonite with 3-aminopropyltriethoxysilane and succinic anhydride, and then carrying out a ring-opening reaction with glycidyl neodecanoate. The coating prepared by the invention has high water resistance, the Kit oil-proof grade is kept at grade 12, and the oil-proof performance of the coating is greatly improved. Meanwhile, the antibacterial performance, the tensile index and the ultraviolet aging resistance are relatively high.

The invention relates to the technical field of sewage treatment, and provides a magnetic multi-effect multi-element composite amphiphilic particle as well as a preparation method and application thereof. The particle comprises a core-shell separated magnetic Fe3O4 particle core and a shell layer, wherein the shell layer is a silicon dioxide / titanium dioxide hybrid shell layer with a fine hole structure; the outer surface of the shell layer comprises a hydrophilic part and a hydrophobic part, the hydrophilic part has an amino group, the amino group is grafted with polydopamine, and gallic acid and catechinic acid are compounded on the polydopamine; poly (diethylaminoethyl methacrylate) is grafted on the inner surface of the shell layer and the surface of the magnetic Fe3O4 particle core. The magnetic multi-effect multi-component composite amphiphilic particle provided by the invention has excellent emulsifying performance and can realize oil-water separation; meanwhile, partial hydrolyzed polyacrylamide can be selectively adsorbed, and oily sewage containing partial hydrolyzed polyacrylamide can be efficiently treated in one step.

The invention belongs to the technical field of biomedical anti-inflammatory gels, and discloses a renewable boundary lubrication natural polyphenol anti-inflammatory hydrogel and a preparation method and application thereof.The hydrogel is of a hydrophilic viscoelastic sea island structure, gallic acid grafted gelatin blended with hyaluronic acid serves as a base material, celecoxib lipidosome is entrapped in the hydrogel, and the hydrogel is prepared from natural polyphenols, an articular cavity is injected through an enzyme crosslinking technology to form gel, hyaluronic acid and lipidosome form a hydrated lubricating layer on a cartilage-gel interface, and after the interface is abraded, internal lipidosome and hyaluronic acid are exposed to supplement lubrication so as to form sustainable lubrication; the liposome responds to friction shear crushing to release celecoxib and cooperates with gallic acid at an interface to resist inflammation progress and repair cartilage, the injectable hydrogel is developed based on gallic acid, hyaluronic acid, gelatin and celecoxib liposome to treat early osteoarthritis, mechanical lubrication and inflammation resistance are combined, and the preparation method has the advantages that the preparation method is simple, the preparation cost is low, and the application prospect is wide. The problems of large-dose toxicity, short lubrication period and the like caused by independent treatment are effectively solved, and the preparation has important clinical application significance.

The invention provides nano-composite hydrogel based on Mg-MOFs (magnesium-metal organic frameworks), which is characterized in that hollow mesoporous silica nanoparticles (HMSNs) are used as a core of the nano-composite hydrogel, magnesium-gallic acid metal organic frameworks (Mg-MOFs) are used as a shell of the nano-composite hydrogel, and a core-shell nano-composite material HMMs is formed; carrying out amination treatment on the core-shell nano composite material HMMs, and loading naringin (Nar) to obtain a drug-loaded core-shell nano composite material (N-HMMs (at) Nar); and carrying out a cross-linking reaction on the drug-loaded core-shell nano composite material (N-HMMs (at) Nar), methacrylic acid gelatin and PEGDA (Polyethylene Glycol Diacrylate), so as to form the nano composite hydrogel. The N-HMMs (at) Nar (at) GP hydrogel prepared by the invention has great application potential in bone defect repair.

The invention belongs to the technical field of intelligent food packaging films, and particularly relates to a nanometer composite fiber film based on vegetable protein and application of the nanometer composite fiber film. The preparation method comprises the following steps: dissolving gallic acid, an anthocyanin composite extract and rapeseed protein in deionized water, and uniformly stirring to obtain a spinning core solution; the preparation method comprises the following steps: dissolving zein in acetic acid, and then adding into water to obtain zein soluble liquid; uniformly mixing and stirring the zein solution and the Arabic gum mixed solution to obtain a shell solution; the shell liquid and the core liquid are subjected to coaxial electrostatic spinning, tin foil paper serves as a receiving base material and is collected through a rotary drum, and finally the nano-composite fiber membrane is obtained. According to the method, the color development difference of anthocyanin under different pH conditions is widened, the color development sensitivity is improved, and the freshness of food can be judged more visually according to color changes. Meanwhile, the composite membrane prepared through electrostatic spinning has larger specific surface area and higher ductility, and the mechanical performance of the composite membrane is improved.

The invention provides melogabalin besylate tablets and a preparation method thereof. The melogabalin besylate tablets comprise melogabalin besylate, a filler, a disintegrating agent, an acid stabilizer, an antioxidant, a lubricant, a flow aid and a gastric-soluble film coating agent. The antioxidant comprises gallic acid, the acid stabilizer comprises maleic acid, and the filler comprises directly pressed starch, isomaltitol, mannitol and microcrystalline cellulose. By screening the antioxidant and the acid stabilizer, the stability of the tablet in the storage period is improved.

The invention discloses a zirconium-based MOF material and a preparation method and application thereof, in the zirconium-based MOF material, metal ions are Zr < 4 + >, an organic ligand is ellagic acid, a conditioning agent is gallic acid, and the material has an oxygen vacancy structure and a hierarchical pore structure; the preparation method comprises the following steps: (1) mixing ellagic acid, gallic acid, zirconium oxychloride octahydrate and a solvent, and carrying out solvothermal reaction; and (2) washing and drying the solid after the reaction in the step (1) to obtain the zirconium-based MOF material. According to the invention, renewable and low-cost ellagic acid and gallic acid are respectively used as an organic ligand and a conditioning agent, and an oxygen vacancy structure is constructed in a competitive coordination manner, so that more hydroxyl and unsaturated metal Zr active sites are exposed, the interaction with formaldehyde (HCHO) is enhanced, and meanwhile, the oxygen vacancy structure can be used as an oxygen vacancy catalyst. And the existence of the hierarchical pore structure can effectively promote mass transfer, so that the HCHO adsorption capacity is improved.

The invention provides a tropical fruit preservative film which is of a double-layer structure, the outer layer is a moisture-resistant antibacterial layer, and the inner layer is a water-absorbing antifogging antibacterial layer; and the water-absorbing anti-fog antibacterial layer also comprises a pH sensitive microcapsule. The outer layer is prepared from polyhydroxyalkanoate, a humidity sensitive type block copolymer and CuO / SiO2 antibacterial nano-enzyme; and the water-absorbing anti-fog antibacterial layer comprises polyhydroxyalkanoate, a humidity-sensitive block copolymer, hygroscopic zeolite, thymol, gallic acid and a pH-sensitive microcapsule. The preservative film has a certain hydrophobic effect, the humidity of a packaging microenvironment can be adjusted, breeding of putrefying bacteria can be inhibited, meanwhile, thymol and gallic acid form a slow-release antibacterial system, and tropical fruits keep good quality in the storage and transportation links through cooperation of all the components; besides, the pH sensitive microcapsules can respond to acidic substances generated by corruption in real time, help merchants to quickly sort deteriorated fruits, and provide a visual judgment basis for consumers at the same time.

The invention discloses a preparation method of a polyphenol-containing medical adhesive. The preparation method comprises the following steps: respectively preparing a gelatin solution, a gallic acid solution and a tea polyphenol solution; mixing the gelatin solution and the gallic acid solution, and reacting at 40-60 DEG C for 6-12 hours to obtain a modified gelatin solution; mixing the tea polyphenol solution with the modified gelatin solution, adding an alkaline solution to adjust the pH value to 6.5-8.0, and uniformly mixing to obtain a mixed solution; the mixed solution is aged at 20-40 DEG C, water generated in the aging process is removed, and the polyphenol-containing medical adhesive is obtained. According to the preparation method of the polyphenol-containing medical adhesive, a gelatin protein molecular chain is used as a framework material, gallic acid is introduced into the protein molecular chain, tea polyphenol is used as a main chain cross-linking agent, the polyphenol-containing medical adhesive is prepared, a phenolic hydroxyl group can penetrate through a water boundary layer on the surface of a base material to form an adhesive bond with the base material, and the medical adhesive has the advantages that the water boundary layer can penetrate through the water boundary layer; good wet adhesion is shown on tissues.

The invention discloses a method for improving in-vivo and in-vitro antioxidant activity of pomegranate peel polyphenol extract through combined enzymolysis of tannase and beta-glucosidase, and relates to the technical field of food science and biology. The pomegranate peel polyphenol extract provided by the invention is obtained from pomegranate peel powder through solvent extraction. According to the present invention, tannase and beta-glucosidase are adopted to perform single or combined enzymolysis on the pomegranate peel polyphenol extract, and the determination on the in vitro antioxidant activity of the pomegranate peel polyphenol extract shows that the antioxidant activities of DPPH and ABTS after the combined enzymolysis are improved by 29.84% and 29.30% compared with the antioxidant activities of the untreated polyphenol extract; the UPLC-ESI-QTOF-MS is used for identifying and analyzing the components of the enzymatic hydrolysate, the content of macromolecular ellagic tannin is obviously reduced, and the content of micromolecular ellagic acid and gallic acid is increased. The enzymolysis polyphenol is applied to D-galactose induced oxidative stress mice, and the result shows that the oxidative damage relieving effect of the enzymolysis polyphenol on the mice is better than that of untreated polyphenol.

The invention relates to the field of biomedicine, particularly provides a copper-based nano-enzyme as well as a preparation method and application thereof, and aims to solve the problems that in the prior art, clinical treatment on primary sclerosing cholangitis (PSC) is difficult in diagnosis and lacks of effective treatment drugs. The copper-based nano-enzyme comprises a nano-enzyme carrier and a copper-based nano-enzyme, wherein the nano-enzyme carrier is a two-dimensional nanosheet formed by copper ions, gallic acid and ursodesoxycholic acid through coordinate bonds; the probe molecule is a cyanine dye molecule connected to the surface of the nano-enzyme carrier through a covalent bond; wherein the fluorescence intensity of the copper-based nano enzyme is enhanced after the action of the alkaline phosphatase. The three functions of alkaline phosphatase responsive diagnosis, nano-enzyme catalytic treatment and ursodesoxycholic acid hepatic targeting are innovatively and synergistically integrated into one nano platform, the treatment function can be executed while specific imaging diagnosis is performed on diseases, and a new strategy is provided for diagnosis and treatment of diseases such as PSC.

The invention provides a Chinese date modified acidic polysaccharide. Each 100 mg of the Chinese date modified acidic polysaccharide contains 90.26 mg + / -1.39 mg to 94.42 mg + / -1.83 mg of total polysaccharide, the total uronic acid content is 21.42 mg + / -1.01 mg to 50.72 mg + / -0.62 mg; total bound phenol: 0.65 mg of GAE + / -0.05 mg of GAE-1.21 mg of GAE + / -0.03 mg of GAE (equivalent weight of gallic acid). The invention also provides a preparation method and application of the jujube modified acidic polysaccharide. The jujube acidic polysaccharide is modified through a low-temperature alkaline deesterification technology, a directional enzyme digestion technology and a controllable partial acid hydrolysis technology, the in-vivo and in-vitro immunomodulatory activity of the jujube acidic polysaccharide before and after modification is compared, and the immunomodulatory activity of the jujube modified acidic polysaccharide obtained through modification is remarkably enhanced; especially, the jujube modified acidic polysaccharide with araban side chains removed and galactan side chains reduced has better immunocompetence.

The invention relates to waterborne polyurethane as well as a preparation method and application thereof. The waterborne polyurethane is prepared from the following raw materials: diisocyanate, polyol, a chain extender, gallic acid, a salt-forming agent and a metal organic framework, the metal organic framework is composed of a metal center and an organic ligand; the metal center comprises copper and / or zinc; the organic ligand comprises an organic matter containing carbonyl and hydroxyl. The gallic acid and the metal organic framework are introduced into the preparation raw materials of the waterborne polyurethane to synergistically improve the mechanical strength and the self-healing performance of the material, and meanwhile, the waterborne polyurethane is endowed with antibacterial ability, so that the waterborne polyurethane can meet the application requirements of more fields.

The disclosure relates to a traditional Chinese medicine composition, comprising active ingredients derived from Cornu caprae or Cornu saigae tataricae, Radix scutellariae, Bulbus fritillariae ussuriensis, Radix glycyrrhizae, Radix et rhizoma rhei, Gypsum fibrosum, Calculus bovis artifactus and Lapis Chloriti, the said active ingredients comprise in parts by weight: at least 1600 parts of amino acids; at least 120 parts of gallic acid; at least 130 parts of liquiritin; at least 20 parts of liquiritigenin; at least 400 parts of baicalin; at least 40 parts of oroxyloside; at least 120 parts of wogonoside; at least 280 parts of glycyrrhizic acid; at least 12 parts of chrysin-7-O-β-D-glucoronic acid; at least 50 parts of aloe-emodin-8-O-β-D-glucopyranoside; at least 30 parts of chrysophanol-1-O-β-D-glucopyranoside; at least 45 parts of chrysophanol-8-O-β-D-glucopyranoside; at least 260 parts of hyodeoxycholic acid; at least 150 parts of cholic acid. The traditional Chinese medicine composition in the present invention possess antipyretic, anti-inflammatory and antitussive effects.

The invention relates to the field of cosmetics, in particular to the field of A61K8, in particular to a multi-effect skin-care liposome whitening composition and a preparation method thereof. The multi-effect skin-care lipidosome whitening composition is prepared from the following raw materials: a whitening functional component, polyhydric alcohols, an emulsifier, a plant extract, lipidoids and deionized water, wherein the whitening functional component is prepared from glabridin, tranexamic acid, nicotinamide, acetylchitosamine, diglucosyl gallic acid, ectoin and ergothioneine. The multiple-effect skin-care liposome whitening composition has the effects of inhibiting the activity of tyrosinase, improving the DPPH clearance rate, inhibiting hyaluronidase and the like, and it is guaranteed that the product has excellent whitening and skin-care effects.