304 results about "Gallic acid ester" patented technology

The invention discloses a graphene oxide-chitosan-carboxymethyl cellulose composite aerogel and an application of the graphene oxide-chitosan-carboxymethyl cellulose composite aerogel in adsorption of amaranth. The preparation method comprises the following steps: mixing a carboxymethyl cellulose aqueous solution with a chitosan acetic acid solution, adding gallic acid, stirring until the gallic acid is completely dissolved, adding the graphene oxide dispersion liquid, and stirring until a system forms uniform and stable gel; the gel is firstly subjected to ultralow-temperature freezing and then subjected to freeze drying, and finally the graphene oxide-chitosan-carboxymethyl cellulose composite aerogel is obtained. The aerogel prepared by the method is environment-friendly and stable in pore structure, and is a composite aerogel material with high adsorption capacity and good regeneration performance on anionic dyes. The adsorption capacity of the aerogel to amaranth can reach 125 mg / g, the adsorption rate is still kept at 77% after the aerogel is recycled for 3 times, and the aerogel is suitable for efficient treatment of dye wastewater.

The application belongs to the technical field of polymer materials, and particularly relates to a high-performance fiber composite material and a preparation method thereof. The preparation method of the high-performance fiber composite material comprises the following steps: adding pretreated aluminum oxide whiskers into a solvent, then adding pretreated carboxymethyl cellulose and gallic acid, and heating to reflux to obtain modified aluminum oxide whiskers; then mixing epoxy resin, the modified aluminum oxide whiskers, a curing agent and an accelerator uniformly to coat a film to obtain a resin adhesive film; and compounding the resin adhesive film and carbon fibers through hot pressing to obtain carbon fiber prepreg, and heating and curing the obtained prepreg to obtain the high-performance fiber composite material. The fiber composite material obtained by the application not only has high strength and rigidity, but also has excellent toughness, can effectively resist the impact of the external environment, has oxidation resistance and long-term stability, and has a wide application prospect in the fields of aerospace and new energy equipment.

This invention belongs to the field of traditional Chinese medicine preparation analysis, specifically disclosing a one-test-multiple-evaluation method for determining the content of seven components in Jinteng Qingbi granules and its application. Using sinomenine as an internal standard, a one-test-multiple-evaluation method is used to establish relative correction factors between sinomenine and gallic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid B, and isochlorogenic acid C in Jinteng Qingbi granules. The contents of gallic acid, neochlorogenic acid, sinomenine, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid B, and isochlorogenic acid C in Jinteng Qingbi granules are calculated using these correction factors. This invention's method is highly practical, simple to operate, cost-effective, and provides accurate and reliable test results, overcoming the shortcomings of existing methods for quality testing of Jinteng Qingbi granules and providing a new approach for quality control and intrinsic quality evaluation of Jinteng Qingbi granules.

The invention relates to a preparation technology of an active bio-based food preservative film with high barrier property and high antibacterial rate, in particular to the field of food packaging and food preservation. The method comprises the following steps: by taking chitosan as a matrix, firstly, loading gallic acid by using nanoparticles prepared from the chitosan and sodium tripolyphosphate; and then, adding the chitosan nanoparticles loaded with gallic acid into a chitosan polymer network to prepare a chitosan-nanoparticle composite film, and preparing the film with high flexibility, high barrier property and high antibacterial activity. The aquatic product preservative has excellent mechanical property, barrier property, biological activity and biodegradability, can effectively prolong the shelf life of aquatic products, and has wide application prospects in the fields of food industry, preservation and the like.

The invention discloses high-purity nickel powder prepared from plant polyphenol through field flow control, a system and a method, a sulfonated tannic acid-gallic acid bio-based system is used as a reduction-stabilizer, and green and efficient preparation of nickel nano powder is realized through a multi-physical field synergistic effect of a three-stage gradient continuous flow reactor and double-frequency ultrasonic-pulse microwave-nitrogen bubbling. The total residence time of the reaction is 25.1-37.7 min, mother liquor is reused after being subjected to salt separation treatment (nanofiltration desalination of a NiSO4 system and ion exchange Cl removal of a NiCl2 system), and the wastewater discharge amount is greatly reduced compared with that of a traditional process; the surface oxygen content of the product is smaller than or equal to 0.9 wt%, the PDI is smaller than or equal to 0.15, the tap density is larger than or equal to 4.0 g / cm < 3 >, the GB / T 33828-2017 standard is met, the method can be used for the high-end field of lithium ion batteries and the like, and green industrial production of the nanometer nickel powder is achieved from the source.

A curcumin nanococrystal composition including curcumin, a coformer, and a stabilizer. The coformer may include at least one of 3,5-dinitrobenzoicacid, gentisic acid, phloroglucinol, 4,4-bipyridine, tartaric acid, citric acid, and gallic acid. The curcumin nanococrystal composition has a particle size less than 10 nm, and the curcumin has a water-solubility between 5 mg / ml and 20 mg / ml.

The invention provides an aluminum alloy pretreatment method based on complex reaction, which comprises the following steps: S1, polishing an LDH (Layered Double Hydroxides) growth surface by using abrasive paper, and cleaning and drying; s2, preparing a complexing agent solution, wherein a complexing agent is selected from at least one of tannic acid, gallic acid and protocatechuic acid; s3, the aluminum alloy sample treated in the step S1 is put into the complexing agent solution in the step S2, and constant potential is applied to the aluminum alloy; s4, preparing a mixed solution of Zn (NO3) 2.6 H2O and NH4NO3, and adding an ammonia water solution to adjust the pH value to 6-6.5; s5, immersing the aluminum alloy treated in the step S3 into the mixed solution in the step S4, and putting the aluminum alloy into a constant-temperature water bath kettle to generate a Zn-Al-LDH film; and S6, after the hydrothermal reaction is finished, cooling to room temperature, and washing and drying the obtained reaction product. The surface of the aluminum alloy is pretreated through the complexing agent, the potential between an intermetallic compound and an aluminum matrix can be effectively balanced, the micro-couple effect is fundamentally inhibited, and ideal conditions are created for uniform, compact and defect-free growth of LDH.

The present application relates to a kind of nanodroplet system based on interface crosslinking curcumin and its preparation method, by the crosslinking complexation between gallic acid ester, metal ion, curcumin to construct nanodroplet system.Gallic acid ester is polyphenol compound, contains a large number of phenolic hydroxyl in structure, has strong chelating metal ability, can be complexed with most of trivalent metal ions and divalent excessive metal ions, called metal phenolic network;Metal ions such as copper, iron and other metal ions form complex by electrostatic interaction with the beta diketone group in the structure of curcumin.Therefore, the nanodroplet system constructed by the present application can maintain the chemical stability and light stability of curcumin, and has wide prospect for improving the current food field curcumin low solubility, poor stability and other problems.

The invention relates to a spleen-tonifying, appetite-stimulating and digestion-promoting traditional Chinese medicine preparation UPLC detection method and a fingerprint spectrum, and belongs to the technical field of medicine detection. The invention aims to solve the technical problems that the existing quality control method of the spleen-tonifying, appetite-promoting and digestion-promoting pills lacks comprehensive and objective analysis on the spleen-tonifying, appetite-promoting and digestion-promoting pills, and the problems of low precision, poor reproducibility, low efficiency and the like during detection of related components in the prior art are solved. According to the technical scheme, the UPLC detection method is characterized in that a mixed standard substance of gallic acid, 5-hydroxymethylfurfural, chlorogenic acid, sinapine thiocyanate, sinapic acid, hyperoside, 3, 6-dimustard acyl sucrose, hesperidin, naringenin, nobiletin and hesperetin is taken as a contrast, an acetonitrile-0. 1% formic acid aqueous solution is taken as a mobile phase, gradient elution is carried out, and the content of chlorogenic acid in the sample is detected. The qualitative and quantitative detection of the effective components of the spleen-tonifying, appetite-promoting and digestion-promoting pill is realized.

This invention relates to the field of textile materials technology, and proposes a fiber for headscarves and its preparation method. The fiber for headscarves comprises the following components by weight: 100 parts PET resin, 2-4 parts modified graphene oxide, 8-10 parts toughening agent, and 0.5-1 parts antioxidant; the modified graphene oxide comprises the following raw materials by weight: 2-5 parts gallic acid fatty ester and 1 part graphene oxide. This technical solution solves the problem of low strength in existing PET fibers for headscarves.

The invention provides a nano drug-loaded particle based on gamma-polyglutamic acid and epsilon-polylysine, a composite shell is arranged outside the nano drug-loaded particle, the composite shell is formed through a reaction of gamma-polyglutamic acid and epsilon-polylysine, and a single active component is loaded in the composite shell; the single active component is one of salicylic acid, gallic acid or tea polyphenol. The invention also provides a preparation method and application of the nano drug-loaded particle. According to the nanoparticles, a unified ionic crosslinking process is adopted, and three kinds of nanoparticles with gamma-polyglutamic acid and epsilon-polylysine as composite shells and different single active ingredients loaded on inner cores are prepared respectively. The nanoparticles provided by the invention are stable in structure and good in biocompatibility, and can be used for preparing medicines with anti-aging, antibacterial and anti-inflammatory effects respectively or in combination.

The invention provides a method for synergistically removing impurities through pH regulation and complexing of ionic rare earth ore leachate, the ionic rare earth ore leachate is stirred and mixed uniformly, a plant polyphenol sulfonic acid derivative complexing agent is added, the complexing agent is prepared through sulfonation, neutralization, concentration and drying by taking gallic acid as a raw material, and the complexing agent can automatically regulate the pH value of the solution and stabilize the pH value at 5.1-5.3; under the condition, phenolic hydroxyl groups, carboxyl groups and sulfonic functional groups in complexing agent molecules preferentially form stable precipitates with impurity ions such as Al < 3 + > and Fe < 3 + > in the leachate, and the complexing effect with rare earth ions (RE < 3 + >) is weak; and after the reaction is completed, carrying out solid-liquid separation to obtain the purified leachate and impurity-containing precipitation slag. The method solves the problem of ammonia nitrogen pollution caused by use of ammonium bicarbonate, ammonia water and other ammonium salts in the traditional process, is a novel method with high impurity removal rate, simple process flow and environmental friendliness, and is suitable for industrial application.

The invention discloses a preparation method of intelligent response hydrogel for programmed delivery of hypoxia endogenous stem cell vesicles and application of the intelligent response hydrogel in promotion of postoperative peritoneum non-adhesion healing. The hydrogel is formed by crosslinking a first component, namely gallic acid modified chitosan loaded with hypoxia energizing stem cell vesicles, and a second component, namely aminophenylboronic acid grafted oxidized hyaluronic acid, and a double-network structure is constructed through a phenylboronic acid ester bond and a dynamic covalent imine bond. The hypoxia energizing stem cell vesicles cooperate with the hydrogel matrix to promote polarization of macrophages to an anti-inflammatory repair phenotype, and peritoneum repair is promoted. Phenylboronic acid ester bonds in the hydrogel respond to high active oxygen level programmed delivery of the hypoxia energizing stem cell vesicles in a postoperative injury area to form material response and biological intervention synergy, so that the problem that the stem cell vesicles are difficult to accurately regulate and control adhesion forming key links is solved; and a comprehensive solution with physical barrier and tissue repair functions is provided for postoperative peritoneum non-adhesion healing.

The invention discloses a preparation and processing method of coconut-based metagen coffee, and belongs to the field of coffee processing. Coconut water is fermented by lactobacillus plantarum HNU531, a drying aid beta-cyclodextrin is added, and freeze drying is performed to prepare the coconut-based metagen, and the coconut-based metagen has good solubility. By additionally adding the coconut-based metagen into the instant coffee, the contents of gallic acid, isomaltose, trehalose and the like which are beneficial to a human body in the coffee can be increased. The sour taste and bitter taste of the coffee can be reduced, and the quality of the coffee is improved.

The invention belongs to the technical field of fine chemical engineering, and relates to a method for recovering 5-acetoacetamidobenzimidazolone, which comprises the following steps: adding a stabilizer into AABI acylation wastewater, concentrating under reduced pressure, cooling to 25-30 DEG C, carrying out suction filtration, and taking a filter cake for later use; adding methanol into a filter cake, dispersing and stirring for 0.5 hour, adding corresponding sodium alkoxide, stirring for 0.5 hour, adding activated carbon, stirring for 0.5 hour, decolorizing, carrying out suction filtration, and concentrating filtrate until no fraction appears; and adding water into the concentrated filtrate for refining, dropwise adding acetic acid to adjust the pH value, stirring for 0.5 h, carrying out suction filtration, and washing and drying a filter cake to obtain an AABI product. The gallic acid is selected as a stabilizer, in the high-temperature concentration process, the AABI structure cannot be damaged, water-soluble salts are filtered out after concentration, impurities are removed through alcohol dispersion and alkali adjustment through sodium alcoholate, then a qualified product is obtained through aqueous phase inversion, the purity is larger than or equal to 99.60%, operation is simpler, conversion is easier, and application and popularization are facilitated.

The present invention relates to a nanoparticle system comprising a metal selected from silver and gold, coated with polyethylene glycol (PEG) and functionalised with a polyphenol organic acid selected from caffeic acid, gallic acid and ferulic acid. The present invention also relates to a method for manufacturing said nanoparticle system and to the therapeutic and cosmetic use of said nanoparticle system.

The present application relates to a kind of self-setting composite bone implants based on gallic acid complex salt and preparation method thereof, belong to bone repair material field.The present application is specifically related to a kind of self-setting composite bone implants, it is characterized in that, component A, component B and component C, the component A is gallic acid and the complex salt of at least two metal elements, wherein the at least two metal elements are the metal element of promoting bone tissue regeneration or the trace metal element required by human body, and the at least two metal elements include calcium, the component B is the complex of calcium / strontium chondroitin sulfate and calcium sulfate, and the component C is magnesium calcium hydrogen phosphate complex.The self-setting composite bone implant of the present application has the characteristics of antibacterial, anti-inflammatory, promoting osteogenesis, instant shaping and all degradation, can meet the clinical needs of bone tumor, bone injury and the like, has wide application prospect in various bone repair, reconstruction and replacement.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to clofazimine-organic acid co-crystals, a preparation method and application thereof. The clofazimine-organic acid co-crystal is one of clofazimine-ferulic acid monohydrate co-crystal, clofazimine-ferulic acid co-crystal, clofazimine-glutaric acid co-crystal, clofazimine-glycolic acid co-crystal (CFZ-GA 1:1), clofazimine-glycolic acid co-crystal (CFZ-GA 1:1.5), clofazimine-salicylic acid co-crystal, clofazimine-L-aspartic acid co-crystal, clofazimine-L-pyroglutamic acid co-crystal, clofazimine-gallic acid co-crystal, clofazimine-succinic acid co-crystal, clofazimine-tartaric acid co-crystal and clofazimine-DL-mandelic acid co-crystal. The clofazimine-organic acid co-crystal provided by the application significantly improves the solubility and fluidity of clofazimine, thereby improving the bioavailability of clofazimine, and has a broad medicinal prospect.

The invention belongs to the technical field of wine brewing, relates to a natural sweet wine low-sulfur brewing method for delaying white grapes until the white grapes turn red and then harvesting the white grapes, solves the health hidden danger and flavor defects caused by high-sulfur addition in the traditional sweet white wine process, and remarkably improves the flavor quality of the wine at the same time. According to the method, complete and healthy red (total anthocyanin content is greater than or equal to 5mg / kg) fruits are selected through artificial spike selection and grain selection, and the cardinal number of infectious microbes in raw materials is reduced; no commercial yeast is added, natural slow fermentation is achieved by means of microorganisms, and the finished product is good in flavor and quality; gallic acid, condensed tannin and hydrolyzed tannin with a ratio of 1: 1: 1 are compounded to prepare wine-brewing tannin, and the wine-brewing tannin and low-dose sulfur dioxide construct a synergistic system, so that the sulfur consumption of sulfur dioxide is greatly reduced, secondary fermentation of high-sugar wine liquid is prevented, and infectious microbes and wine body oxidation are effectively inhibited. The finished product biogenic amine, pesticide and heavy metal residues all meet the safety standard, mycotoxin is not detected, meanwhile, the original flavor of the wine body is prominent, the storage stability is good, and dual guarantee of health and quality is achieved.

New derivatives of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo [3,4c] pyridine-3-carboxamide (Apixaban) able to increase its water solubility. These derivatives are cocrystals derivatives ofApixaban of different acids, from which the most outstanding are the following: Apixaban Malonic Acid derivative, Apixaban-a-Ketoglutaric Acid derivative, Apixaban-Gallic Acid derivative, Apixaban-Maleic Acid derivative, Apixaban-L-Tartaric Acid derivative, and Apixaban Citric Acid derivative.

The invention discloses a platelet increasing capsule characteristic chromatogram and a construction method and application thereof, and belongs to the technical field of quality control of traditional Chinese medicine compound preparations. According to the method, 13 control components including gallic acid, catechin, paeoniflorin, forsythiaside B, benzoic acid, astragalus smicus glycoside, forsythin, arctiin, liquiritigenin, benzoyl paeoniflorin, paeonol, arctigenin and indirubin are selected, a high performance liquid chromatography-mass spectrometry technology is applied, multiple batches of preparation samples are analyzed, and the content of the components in the preparation samples is determined. And establishing a characteristic spectrum of the chemical components. Compared with a traditional method, the technology has good precision and reproducibility, the data result is accurate and reliable, meanwhile, the technology can identify the 13 components at the same time under the same chromatographic condition, the analysis efficiency is remarkably improved, synchronous monitoring of multiple effective components is achieved, and the consistency and stability of the preparation quality can be guaranteed.

This invention relates to the field of traditional Chinese medicine analysis, and particularly to a method for determining the content of multiple components in Terminalia chebula and constructing its characteristic fingerprint spectrum. The method provided by this invention can simultaneously determine chebulin, gallic acid, 4-galloshikimic acid, 5-galloshikimic acid, punicalin (punicalin A&B), corilagin, 1,3,6-tri-O-galloyl-β-D-glucose, chebulin, urolithin M5, chebulin tannic acid, chebulin-lintannic acid, and ellagic acid in Terminalia chebula. It exhibits high sensitivity, good precision, repeatability, and stability, and can be used to detect the tannin content in the extract at each step of the tannin extraction process, as well as for related detection in the study and quality evaluation of tannin components in Terminalia chebula. It can also be used to construct the characteristic fingerprint spectrum of Terminalia chebula. This method can also be used for determining the content of tannin compounds and constructing their characteristic fingerprint spectrum in Terminalia chebula, which contains similar tannin compounds to Terminalia chebula.

The application belongs to the field of enzyme engineering and biotechnology, and discloses a 4-hydroxybenzoic acid hydroxylase mutant and application thereof in synthesis of gallic acid or a salt thereof. The 4-hydroxybenzoic acid hydroxylase mutant is obtained through directional evolution modification and high-throughput screening, and has an increased protocatechuate hydroxylase activity by more than 4 times. The 4-hydroxybenzoic acid hydroxylase mutant is expressed by using E. coli, and the obtained recombinant E. coli can efficiently catalyze the conversion of protocatechuate into gallic acid. The 4-hydroxybenzoic acid hydroxylase mutant is expressed in the recombinant E. coli for producing protocatechuate, and the obtained recombinant E. coli can de novo synthesize gallic acid from glucose as a substrate, and the yield reaches 58.65 g / L, and the residual amount of protocatechuate is only 0.33 g / L. The application solves the problem of a large amount of residual protocatechuate in the fermentation process of the existing strains, and can provide an efficient enzyme element for the creation of gallic acid industrial strains.

The invention belongs to the technical field of biology, and discloses application of DVM nanoparticles in preparation of products for treating and / or preventing alcoholic liver diseases, the DVM nanoparticles contain gallic acid derivatives VM and dihydromyricetin; the mass ratio of the gallic acid derivative VM to the dihydromyricetin is 1: 3; in alcohol-induced HepG2 cells, the DVM nanoparticles can better reduce apoptosis of hepatocytes and generation of ROS, improve ADH activity, reduce AST and ALT activities in the cells and improve the hangover alleviating ability in mice, and have a more excellent liver protection effect compared with gallic acid and a positive drug silibinin.

This invention provides a plant growth regulatory activity of a new biologically active synthetic molecule methanone-(3′,4′,5′-trimethoxy) phenyl, 1-naphthyl, 2-O-4″-ethyl but-2″-enoate. More particularly, the invention relates to the potent plant growth promoting activity of a gallic acid derivative having a structure represented by Formula 1 and a molecular formulae C26H26O7. This invention also provides a novel process for preparation of said molecule from a naturally occurring compound and testing it for growth regulating activity using Bacopa test system developed at CIMAP (Khanuja et al., 2001).

This invention relates to the field of bioimmobilization technology, and discloses a metal-organic framework composite material, its preparation method and application, a method for immobilizing biomolecules, and the immobilization of biomolecules. The metal-organic framework composite material comprises a metal-organic framework material and natural polyphenols modified on the surface of the metal-organic framework material; wherein the metal-organic framework material is UIO-66-NH2, and the natural polyphenols are selected from at least one of tannic acid, gallic acid, and dopamine. This metal-organic framework composite material can achieve efficient, mild, and stable immobilization of biomolecules, significantly improving the versatility, catalytic activity, and stability of immobilized biomolecules.

This invention discloses a compound preparation for treating vascular dementia and its preparation method. The active pharmaceutical ingredient consists of protopanaxadiol and gallic acid in a 1:1 mass ratio, and the dosage form is liposomes. The preparation method includes extraction, mixing, liposome preparation, and optional freeze-drying steps: protopanaxadiol and gallic acid are extracted and purified from ginseng rhizome and Terminalia chebula fruit, respectively. After mixing, they are combined with phospholipids and cholesterol to prepare a lipid membrane. The membrane is then homogenized by hydration, low-temperature ultrasound, and high-pressure microfluidic jet to obtain a homogeneous liposome suspension, which can be further freeze-dried into a freeze-dried powder. The 1:1 composition of protopanaxadiol and gallic acid targets multiple points on the pathological mechanism of vascular dementia, showing significant therapeutic effects and broad application prospects. This preparation uses a liposome dosage form to improve the bioavailability of the active ingredient, the preparation process parameters are controllable, the active ingredient has high purity, the liposomes have uniform particle size, high encapsulation efficiency, and good stability.

To provide a whitening composition that has excellent whitening effects. [Solution] The present invention provides a whitening composition comprising eugenin, ellagic acid, and gallic acid, wherein the content of ellagic acid per 1 part by mass of eugenin is 5 parts by mass or more and 15 parts by mass or less, and the content of gallic acid per 1 part by mass of eugenin is 10 parts by mass or more and 30 parts by mass or less. Furthermore, the content of ellagic acid in the whitening composition is X EA [Mass %], gallic acid content is X GA When expressed as [mass %], 0.34 ≤ X EA / X GA It is preferable that the condition ≤0.80 is met. Furthermore, it is preferable that the sum of the content of eugenin, ellagic acid, and gallic acid in the whitening composition is 1.41% by mass or more and 1.85% by mass or less.