524 results about "Gallic acid" patented technology

The invention discloses a glucose response type insulin delivery system as well as a preparation method and application thereof, and belongs to the technical field of biological materials. The glucose response type insulin delivery system provided by the invention comprises a delivery carrier and a bioactive component encapsulated in the carrier, the delivery carrier is a metal polyphenol network formed by carrying out coordination reaction on epigallocatechin gallate and metal ions; the bioactive components comprise glucose oxidase, catalase and insulin. The glucose response type insulin delivery system provided by the invention can adjust the release of insulin according to the concentration of glucose in the surrounding environment, so that the blood glucose is maintained at a normal level.

The invention discloses composite hydrogel as well as a preparation method and application thereof. The curcumin-EGCG composite hydrogel is prepared by forming a complex through hydrogen-bond interaction between gelatin and epigallocatechin gallate and carrying out chemical crosslinking through Schiff base reaction of curcumin and gelatin. The composite hydrogel disclosed by the invention has a self-healing characteristic or viscosity and a shear thinning characteristic, and is beneficial to local application. The composite hydrogel is loose and porous in structure, the drug loading rate can be increased, the drug can be slowly and controllably released, the treatment effect of the composite hydrogel in androgenetic alopecia is promoted, meanwhile, the solubility of a drug monomer can be remarkably improved, and the problem that the drug solubility is low is solved. The composite hydrogel provided by the invention provides an effective transdermal drug delivery preparation for treatment of skin diseases, and has good clinical application prospects and development values.

The invention provides a composition for promoting hair regeneration after chemotherapy as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: modifying the surface of a gold nanocage with polydopamine, loading the modified gold nanocage on an exosome, complexing magnesium ions and zinc ions to prepare a modified exosome, preparing a nano drug-loaded liposome from curcumin, resveratrol and epigallocatechin gallate, mixing the nano drug-loaded liposome with the modified exosome to prepare a multi-layer liposome, and preparing the multi-layer liposome from the nano drug-loaded liposome. And mixing with a penetration enhancer, and adding into a temperature-sensitive hydrogel system to prepare the composition for promoting hair regeneration after chemotherapy. The composition for promoting hair regeneration after chemotherapy has a good transdermal absorption promoting effect, can slowly release drugs, promotes hair follicles to be converted from a resting stage to a growing stage under the synergistic effect of the drugs, regulates and controls multiple pathways (such as anti-apoptosis, angiogenesis promotion and anti-inflammation) at the same time, is matched with a complex pathological mechanism of hair regeneration after chemotherapy, and can promote hair regeneration after chemotherapy. Wide application prospects are realized.

The invention relates to the technical fields of medicines, foods, daily chemicals and the like, in particular to two supramolecular eutectic crystals for better solving the application problem of EGCG (epigallocatechin gallate). The preparation method comprises the following steps: firstly, enabling EGCG and betaine to form a supramolecular EGCG betaine eutectic through a supramolecular technology, and synthesizing the supramolecular EGCG betaine eutectic through a supramolecular modification reaction by taking EGCG and betaine as precursors, so that the stability of EGCG can be improved to a certain extent, and meanwhile, the EGCG and the betaine are combined to play a synergistic effect; the supramolecular raw material is formed by enabling supramolecular EGCG betaine eutectic crystals and cyclodextrin to form a supramolecular raw material through host-guest self-assembly, and hydroxypropyl-beta-cyclodextrin and supramolecular EGCG betaine are subjected to host-guest self-assembly to obtain the supramolecular raw material, the supramolecular raw material prepared by the method can solve the stability problem of EGCG, the bioavailability of EGCG is improved, and the bioavailability of EGCG is improved. And meanwhile, the composition has good effects of resisting oxidation, whitening, resisting inflammation, controlling oil and the like, and has a good application prospect.

The invention discloses a tightening and whitening composition containing EGCG (epigallocatechin gallate) as well as a preparation method and application of the tightening and whitening composition, and relates to the technical field of cosmetics. The invention provides a tightening and whitening composition containing EGCG (epigallocatechin gallate). The tightening and whitening composition is prepared from the following components in parts by weight: 0.1 to 2 parts of an epigallocatechin gallate nano composition, 0.05 to 0.5 part of a nucleic acid tetrahedron and 0.5 to 5 parts of glassine. When the EGCG nano composition, the nucleic acid tetrahedron and the glassine are cooperatively used, the stability of a formula can be improved, meanwhile, the EGCG can be accurately released to an epidermal layer due to the enzyme-responsive degradation characteristic (such as matrix metalloproteinase MMP-2 triggered depolymerization) of the nucleic acid tetrahedron, and the glassine is released after deeply penetrating into a corium layer along with a nucleic acid tetrahedron carrier, so that the EGCG can be accurately released to the epidermal layer. The synergistic effects of the three components on whitening and tightening are better exerted.

The invention discloses a beta-glucuronidase inhibitor composition as well as a preparation method and application thereof. The composition is prepared from the following substances: ursolic acid, procyanidine, icariin, curcumin, epigallocatechin gallate and glycyrrhetinic acid. The beta-glucuronidase inhibitor composition has a broad-spectrum and good inhibition effect, the preparation method is simple, large-scale production is easy, and the inhibitor with a natural source is higher in use compliance, lower in toxic and side effects and more suitable for developing intestinal health products and has an application prospect.

The invention relates to the technical field of hydrogel, in particular to a preparation method and application of EGCG-mediated hydrogel, a lysozyme solution is heated under the acidic condition to form lysozyme amyloid fibrils LAFs, EGCG is dissolved in a buffer solution and mixed with the LAFs solution obtained in the step 1 in proportion to form an LAFs-EGCG compound, and the EGCG-mediated hydrogel is prepared. The chitosan CS is dissolved in an acetic acid buffer solution, glutaraldehyde is added to serve as a cross-linking agent, the mixture is mixed with the LAFs-EGCG compound obtained in the step 2 and stirred, the composite hydrogel is formed, the concentration of EGCG is 0.2-1.0 wt%, the concentration of LAFs is 5 wt%, the concentration of chitosan is 2 wt%, the pH value of the lysozyme solution in the step 1 is 2.0, the heating temperature is 77 DEG C, the heating time is 10 hours, the concentration of EGCG in the step 2 is 0.4-0.8 wt%, and the pH value of the lysozyme solution in the step 2 is 1.5-2.5. In the step 3, the concentration of glutaraldehyde is 2%, the storage modulus G'of the hydrogel is 325-480 Pa, the hardness is 2176.71 g, and the bacteriostasis rate on staphylococcus aureus and salmonella exceeds 95%.

The invention discloses a method for detecting antioxidants and polyphenols in food by constructing a colorimetric sensing array based on monatomic iron nano-enzyme, and belongs to the field of nanotechnology and colorimetric sensing. The traditional monatomic nano enzyme shows limited enzyme-like activity and substrate specificity, and is difficult to meet the comprehensive requirements of detecting various antioxidants and polyphenols in food. In the research, a novel nano-enzyme system (sdsFeN (at) G) of monatomic iron nano-enzyme is developed. The SdsFeN (at) G shows excellent enzymatic activity, and a three-channel colorimetric sensing array is constructed by utilizing inhibition of different antioxidants and polyphenols on oxidation of three chromogenic substrates, so that simple, convenient and reliable identification and detection of five substances (tert-butylhydroquinone, butylated hydroxyanisole, propyl gallate, catechol and hydroquinone) in food are realized.

The invention relates to the technical field of food fresh-keeping materials, in particular to a chitosan-curcumin nano-composite fresh-keeping agent and a preparation method thereof.The chitosan-curcumin nano-composite fresh-keeping agent comprises nano-particles of a chitosan-sodium alginate-oxidized sodium alginate interpenetrating network structure, according to the nanoparticles, protonated amino groups of chitosan and carboxyl groups of sodium alginate form a polyelectrolyte compound core, aldehyde groups of oxidized sodium alginate and amino groups of chitosan are subjected to a Schiff base reaction to form a chemical cross-linked network, and zinc ions, amino groups of chitosan, carboxyl groups of sodium alginate and carboxyl groups of oxidized sodium alginate form coordination cross-linking; curcumin and epigallocatechin gallate form a compound through a hydrogen bond and a hydrophobic effect, the compound is embedded in an interpenetrating network structure, beta-diketone groups of curcumin and zinc ions form chelating coordination, a chitosan-sodium alginate-oxidized sodium alginate ternary interpenetrating network is constructed, and the chitosan-sodium alginate-oxidized sodium alginate ternary interpenetrating network structure is formed. The stability is improved by utilizing the synergistic effect of triple mechanisms of electrostatic interaction, Schiff base chemical bonds and zinc ion coordination.

The invention discloses injectable hydrogel for photo-thermal adjuvant therapy of periodontitis and a preparation method, and belongs to the technical field of high polymer material preparation, the preparation method comprises the following steps: reacting MXene dispersion liquid with epigallocatechin gallate and MgSO4; then sequentially carrying out ultrasonic treatment, centrifugation, washing and freeze-drying to obtain a multifunctional nanosheet MP-Mg; adding the multifunctional nanosheet MP-Mg into an oxidized gellan gum aqueous solution, and carrying out a mixed reaction to obtain a solution A; mixing the quaternary ammonium salt chitosan aqueous solution and the carboxymethyl chitosan aqueous solution in equal volume, and reacting to obtain a solution B; and mixing the solution A and the solution B in equal volume for reaction. The hydrogel prepared by the preparation method disclosed by the invention has injectability, photo-thermal responsiveness, biological membrane penetrability, synergistic antibacterial property and long-acting anti-inflammatory property, and an innovative and practical photo-thermal adjuvant therapy platform is provided for clinical treatment of periodontitis.

The invention relates to a preparation method of an active oxygen responsive microneedle with a separable base, which comprises the following steps: mixing 3-(acrylamide) phenylboronic acid, epigallocatechin gallate and N-vinyl pyrrolidone, and standing to obtain an E-A compound solution; dissolving cyclosporine and an initiator in the E-A compound solution to obtain a microneedle precursor solution; placing the microneedle precursor solution on the surface of a microneedle mold, and performing in-situ polymerization to form a microneedle body; paving a mixed aqueous solution of poly (N-isopropylacrylamide-n-butyl acrylate) and polyvinyl alcohol on the microneedle mold substrate forming the microneedle body, and drying to form a microneedle substrate; and stripping the microneedle body with the microneedle substrate from the microneedle mold to obtain the active oxygen responsive microneedle with the separable base. According to the product prepared by the preparation method, drug release can be adjusted by sensing ROS of an inflammation part, deep penetration of the drug is realized, controllable separation between a backing layer and a needle head can be realized, and discomfort of a patient is reduced.

The invention relates to the field of hydrogel materials, in particular to a hydrogel dressing as well as a preparation method and application thereof. The deferoxamine mesylate is loaded on the gelatin microsphere material constructed by the gelatin and the genipin, so that the loading dispersion of the deferoxamine mesylate can be benefited, and the added gelatin can be in contact with matrix proteinase-9 in a diabetic foot ulcer microenvironment for degradation so as to induce the release of the deferoxamine mesylate. A first cross-linked network is formed by the 3-carboxyphenylboronic acid modified chitosan and the oxidized hyaluronic acid, and the gelatin microsphere material loaded with the deferoxamine mesylate and the epigallocatechin gallate are coated with the first cross-linked network. The hydrogel dressing realizes controllable release of the deferoxamine mesylate and the epigallocatechin gallate, so that the technical problem of uncontrollable release of the deferoxamine mesylate is solved.

The invention discloses a composition capable of resisting inflammation, increasing blood oxygen content, inhibiting cancer cell growth and relieving tumor treatment side effects. The composition is specifically prepared from exocarpium citri grandis, ginseng, cortex cinnamomi, ergothioneine, herba houttuyniae, kelp, herba taraxaci, rhizoma curcumae longae, epigallocatechin gallate, naringin, chitosan oligosaccharide, zinc gluconate and taurine. The composition provided by the invention integrates the treatment concepts of softening hardness to dissipate stagnation in the traditional medicine and treating according to the evidence in the modern medicine, and the raw materials are scientific in compatibility, have a synergistic effect and jointly exert the effects of resisting inflammation, improving body immunity, improving the blood oxygen content level of a focus part and the like; the compound has the advantages of well inhibiting growth of cancer cells, inhibiting expression of hypoxia-inducible factors HIF, relieving side effects of tumor treatment and the like, is safe and efficient, and has a wide application prospect.

Compared with the prior art, the application of the copper-based nano-enzyme to the dual-mode detection of the antioxidant capacity of the tea polyphenol has the beneficial effects that the provided copper-based nano-enzyme is simple to prepare, and an EGCG (epigallocatechin gallate) dual-mode detection method based on the copper-based nano-enzyme is simple, convenient, efficient and high in sensitivity; the method has important application value in the aspect of detecting the equivalent weight of EGCG in the tea leaves and further evaluating the natural antioxidant capacity of the EGCG.

The invention discloses a method for biosynthesizing epigallocatechin gallate glucoside, and belongs to the technical field of biocatalytic synthesis. According to the method, a sucrose phosphorylase mutant is adopted as a catalyst, the sucrose phosphorylase mutant is subjected to single-point mutation or combined mutation on the basis of an amino acid sequence SEQ ID NO.1, and the enzyme activity of the sucrose phosphorylase is improved through mutation; the mutant is utilized to realize efficient catalytic synthesis of epigallocatechin gallate glucoside, and in the whole catalytic process, the synthesis method is mild in condition, simple to operate, short in reaction time and high in catalytic efficiency, and has a good application prospect.

The invention relates to the technical field of green building materials, in particular to phase-change energy-storage thermal insulation mortar and a preparation method of the phase-change energy-storage thermal insulation mortar. 25 to 40 parts of methyl palmitate; 120 to 180 parts of hydrophobic perlite; 8 to 15 parts of expanded graphite; 3-6 parts of phosphorus sheet-shaped aluminum nitride; 180 to 250 parts of sulphoaluminate cement; 60 to 100 parts of volcanic rock micro powder; 0.3 to 0.8 part of hydroxypropyl methyl cellulose; 0.6 to 1.2 parts of a polycarboxylic acid water reducing agent; 2 to 4 parts of nano aluminum oxide; 0.8 to 1.5 parts of propyl gallate; and 1-2 parts of zinc borate. Through the proportion design of the antioxidant flame-retardant microcapsules and the lightweight composite aggregate, the problems of poor thermal conductivity and insufficient durability of a traditional phase change material are solved. Through phase change material loading, interface modification and multi-component cooperative regulation, the thermal insulation performance, energy storage efficiency and structural stability are remarkably improved, and the material is suitable for the fields of building energy saving, intelligent temperature control and the like.

A nutraceutical composition, consisting of Nicotinamide Mononucleotide in a range 250-1000 mg, Spermidine in a range 0.5-10 mg, Rhodiola Rosea in a range 200-600 mg, Cacao in a range 1000-10,000 mg, L-Theanine in a range 50-200 mg, Glucosamine in a range 500-3000 mg, and Hyaluronic acid in a range 50-240 mg, or consisting of Epigallocatechin-3-gallate in a range 100-500 mg, Quercetin in a range 250-1000 mg, Resveratrol in a range 150-1000 mg, Sulforaphane in a range 1-50 mg, and Calcium Alphaketoglutarate in a range 300-2000 mg, or consisting of Microdose Lithium in a range 1-5 mg, Trimethylglycine in a range 500-2000 mg, Glutathione in a range 250-1000 mg, Fisetin in a range 100-1000 mg, Urolithin A in a range 250-2000 mg, Sodium Butyrate in a range 100-3000 mg, Berberine in a range 500-1500 mg, Apigenin in a range 50-500 mg, Cinnamon in a range 1000-6000 mg, and Malate in a range 1000-6000 mg.

The invention discloses a preparation method and application of a targeted delivery system of a metal polyphenol nano system. The invention discloses a targeted delivery system of a metal polyphenol nano system, and a preparation method of the targeted delivery system comprises the following steps: taking the metal polyphenol nano system formed based on epigallocatechin gallate and iron ions as a carrier, and loading fucoxanthin to prepare fucoxanthin nano particles with active oxygen response characteristics; then, after chondroitin sulfate capable of targeting macrophages and (5-carboxyl amyl) triphenyl phosphorus bromide capable of targeting mitochondria are coupled, the fucoxanthin delivery system with the active oxygen response characteristic and the targeting characteristic is further prepared through a double emulsion anti-solvent evaporation method. The system can realize release of fucoxanthin under stimulation of active oxygen, and realizes aggregation of a targeted delivery system in mitochondria of a specific inflammation site. The carrying system can effectively improve or relieve the inflammatory bowel disease, and the raw materials used in the carrying system are low in cost, the preparation conditions are mild, and large-scale production is easy.

The invention provides a bacteriostatic PET (polyethylene terephthalate) coiled material as well as a preparation method and application thereof, and belongs to the technical field of high polymer materials, the bacteriostatic PET coiled material is prepared from the following raw materials: PET, nano titanium dioxide, nano talcum powder, a compatilizer, an antioxidant, a lubricant and a modified composite bacteriostatic agent; the compatilizer is an ethylene-methyl acrylate-glycidyl methacrylate random terpolymer and / or an ethylene-acrylic ester-maleic anhydride random terpolymer, and the compatilizer is an ethylene-methyl acrylate-glycidyl methacrylate random terpolymer and / or an ethylene-acrylic ester-maleic anhydride random terpolymer; the lubricant is one or a mixture of two of pentaerythritol stearate, erucyl amide, polyethylene wax, polyvinyl alcohol and ethylene bis stearamide; the modified composite bacteriostatic agent is prepared from catechin gallate, epsilon-polylysine hydrochloride and modified porous zinc oxide. The prepared antibacterial PET coiled material can be used for packaging materials of packaging boxes, lunch boxes, cup covers, trays and the like, and has good mechanical properties such as bending strength and impact strength and excellent antibacterial performance.

The invention discloses epigallocatechin gallate starch nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. According to the method, high-proportion branched-chain cassava starch is used as a raw material, ultrasonic microwave assistance is adopted, in the nanometer starch alcohol precipitation process, epigallocatechin gallate is synchronously packaged to form nanometer-level epigallocatechin gallate starch nanometer particles, and embedding of epigallocatechin gallate is completed. The embedding rate of the epigallocatechin gallate starch nanoparticles can reach 50.20%, the drug loading capacity can reach 311mg / g, the drug slow release performance is obvious in the process of simulating gastrointestinal digestion, the sustained release time can be 20 hours, the drug release capacity can reach 72.33% and 90.10% respectively, and the preparation process is simple, easy to operate, low in preparation cost and suitable for large-scale production and application.

The invention discloses a compound paracetamol and amantadine hydrochloride capsule which is prepared from the following components in parts by weight: 250 parts of paracetamol, 100 parts of amantadine hydrochloride, 2 parts of chlorpheniramine maleate, 10 parts of calculus bovis factitius, 15 parts of caffeine, 20 parts of propyl gallate, a filler, a disintegrating agent, an adhesive and a lubricant. Propyl gallate is applied to prevent amantadine hydrochloride from being degraded into 2-aminoadamantane, the content of the impurity 2-aminoadamantane is reduced, and the filler, the disintegrating agent, the adhesive and the lubricant in a certain proportion are used for granulation, so that the problem that the dissolution rate is unqualified in the prior art is solved.

The invention discloses a composition containing a polypeptide exosome and application of the composition in preparation of a product with skin repair ability, and particularly relates to the technical field of biology, the composition comprises polypeptide-exosome composite nanoparticles, and a polypeptide containing a GRGDS motif and an umbilical cord Wharton's jelly exosome are covalently crosslinked; the lipid double-layer coating layer comprises phosphatidylcholine, cholesterol and PEG-2000, and the molar ratio of the phosphatidylcholine to the cholesterol to the PEG-2000 is 5: 3: 2; the synergist is prepared from 0.1 to 5 percent of epicatechin gallate and 2 to 8 percent of recombinant collagen III oligopeptide. The nano-liposome is prepared through microfluidic self-assembly and a film hydration-ultrasonic intercalation method, and can be loaded on a degradable microneedle patch, so that targeted slow release of a wound part is realized. Through the synergistic effect of targeted delivery, oxidation resistance and collagen regeneration, the skin repair efficiency is remarkably improved, and the healing time is shortened.

The present invention provides a conjugate comprising: (a) a CNS targeting ligand, (b) a hydrophilic polymer of polyethylene glycol (PEG), polylactic acid (PLA), polylactic acid-co-glycolic acid (PLGA), or glucan, and (c) a flavonoid. The present invention also provides a micelle nanoparticle composition comprising: (a) an outer shell comprising the conjugate, optionally (b) an inner shell comprising oligomeric (-)-epigallocatechin gallate (OEGCG), and optionally (c) a CNS disease treatment molecule encapsulated in the inner shell. The invention also provides a method of treating a CNS disease by administering to a subject an effective amount of a nanoparticle composition of the invention. The CNS targeting ligand targets a CNS tissue and delivers an active ingredient to the CNS tissue for treating a CNS pathological condition.

The invention discloses an anti-aging composition, a preparation method and application of the anti-aging composition in skin aging resistance, belongs to the technical field of cosmetics, and aims at solving the problems that in related technologies, anti-aging cosmetics are instable in functional components, and the skin aging resistance of transdermal absorbability and functional component combination needs to be further improved. The anti-aging composition is prepared from the following components in percentage by total weight of the composition: 10 to 20 percent of an anti-aging functional composition and 80 to 90 percent of an auxiliary material matrix, the composition with the anti-aging effect is prepared from the following main components: ascorbyl tetraisopalmitate, epigallocatechin gallate, hydroxytyrosol, a calendula extract, curcumin, resveratrol and glutathione. The anti-aging composition prepared by the invention has good stability, transdermal absorbability and capability of improving skin aging resistance.

The invention discloses a bio-based flame-retardant composition and application thereof in preparation of a polylactic acid composite material, and belongs to the technical field of polylactic acid composite materials. The bio-based flame-retardant composition comprises phosphorylated chitosan and M-EGCG, M is a transition metal element, and M-EGCG is a complex of epigallocatechin gallate EGCG and a transition metal ion; wherein the mass ratio of the M-EGCG to the phosphorylated chitosan is 1: (1-5). When the bio-based flame-retardant composition is used for preparing the polylactic acid composite material, the flame retardant property of the polylactic acid composite material can be improved, and the mechanical property of the polylactic acid material can be maintained.

The invention discloses a catechin-chitosan oligosaccharide-nano selenium composite material as well as a preparation method and application thereof, and belongs to the technical field of biomass nano materials. The preparation method of the catechin-chitosan oligosaccharide-nano selenium composite material comprises the following steps: firstly, mixing an aqueous solution of sodium selenite and an aqueous solution of epigallocatechin gallate according to the molar ratio of 1: (10-25), and stirring; the catechin-chitosan oligosaccharide-nano-selenium composite material is prepared by adding the catechin into sodium selenite, then adding chitosan oligosaccharide and water, and reacting to obtain the catechin-chitosan oligosaccharide-nano-selenium composite material, the final concentration of the sodium selenite in the reaction system is 1mM, and the final concentration of the chitosan oligosaccharide in percentage by mass is 1-2%. The composite material provided by the invention has relatively excellent antibacterial activity, is easy to clean, natural and environment-friendly, the preservation effect of the composite material applied to the berry fruits is superior to the effect of chitosan under the same concentration, and reference is provided for application ways and product forms such as preservation or packaging of the berry fruits.

The invention discloses double gel loaded with active substances as well as a preparation method and application of the double gel, and belongs to the technical field of medical dressings. The double gel is composed of a water phase and an oil phase, the water phase comprises oxidized sodium alginate and carboxymethyl chitosan, and the oil phase comprises glycerol monolaurate and camellia oil. Through the synergistic effect of a water phase and an oil phase, a stable double-gel system is formed, hydrophilic epigallocatechin gallate and lipophilic curcumin are loaded, and primary encapsulation of active substances is achieved. According to the double gel loaded with the active substance and the preparation method and application thereof, the double gel has excellent mechanical stability and gel performance, can achieve efficient delivery of the active substance, and has good biocompatibility and application prospects; effective treatment is expected to be achieved in acute burn and scald wound repair, theoretical basis and technical support are provided for application of the double gel in the fields of wound repair and medical cosmetology, and the double gel has the potential of replacing a traditional dressing and becoming a new generation of functional medical dressing.

The invention discloses functional recombinant soybean protein isolate emulsion gel as well as a preparation method and application thereof, and belongs to the technical field of soybean protein processing. The preparation method comprises the following steps: recombining three main components, namely soybean lipophilic protein, glycinin and beta-conglycinin, in soybean protein isolate (SPI) according to a certain compounding ratio, and carrying out combined modification on the recombined SPI by virtue of modification means such as ultrasonic treatment, heat treatment, magnetic field and enzyme crosslinking; the recombined SPI emulsion is subjected to micronization treatment by adopting high-pressure microjet homogenization treatment, and then the emulsion is jointly induced to be gelatinized by utilizing acid and salt ions and transglutaminase, so that the preparation efficiency, the structural strength and the stability of the emulsion gel are improved; two polyphenols, namely epigallocatechin gallate and quercetin, are co-embedded in an interface and an oil phase of the emulsion gel, so that the bioaccessibility and antioxidant activity of the polyphenols are improved, and the emulsion gel is endowed with functionality. The prepared emulsion gel can be widely applied to processing of functional food.

The present invention describes a composition comprising an effective amount of a combination of two or more components selected from acacetin, ACT1 peptide, α-lipoic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, β-lapachone, β-hydroxy-β-methylbutyrate, bacopa monnieri, catechins, catechols, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (-)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-α-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercetin (EMIQ), shan Phosphate, black bean anthocyanins, leucine, lithium, luteolin, luteolin, luteolin, melatonin, menadione, 1‑methylnicotinamide (MNA), methyl salicylate, myricetin, nicotinamide adenine dinucleotide, nicotinic acid (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid mononucleotide (NaMN), parsley, phenylephrine, pokeweed mitogen, 15‑Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxerutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin, and zinc (including its salts).

The invention discloses a preparation method of an environment-friendly water-based rubber protective film, and belongs to the technical field of rubber chemical modification. Comprising the following steps: mixing butadiene styrene rubber and nitrile rubber according to a mass ratio of 3: 1 to prepare an emulsion with the solid content of 40-50%, adding nano silicon dioxide and a silane coupling agent, and reacting at 50-60 DEG C for 2-3 hours to obtain a silane modified rubber emulsion; the preparation method comprises the following steps: preparing sodium alginate into a 2-3% aqueous solution, adding tributyl citrate and nano-zinc oxide, and carrying out ultrasonic dispersion for 30 minutes to obtain a composite cross-linking agent solution; dissolving chitosan in an acetic acid solution, adding propyl gallate and nano montmorillonite, and uniformly stirring and mixing to obtain a functional additive solution; adding the composite cross-linking agent solution and the functional additive solution into the modified rubber emulsion; by optimizing a formula system and a preparation process, the problems that an existing water-based protective film is poor in stability, low in drying speed, insufficient in water resistance and difficult to consider both flexibility and adhesive force are solved.