48 results about "Gallic acid" patented technology

This invention belongs to the field of food processing technology, specifically relating to a walnut protein isolate-xanthan gum-epigallocatechin gallate ternary complex, emulsion, its preparation method, and its application. The walnut protein isolate-xanthan gum-epigallocatechin gallate ternary complex in the composite emulsion provided by this invention exhibits reduced particle size, enhanced electrostatic repulsion, and the absence of uneven clumps and particles. The elasticity and viscosity of the composite emulsion are significantly enhanced, and the complex demonstrates comprehensive environmental stability over a wide range of pH, salt concentration, and temperature conditions.

The application provides a method for preparing epigallocatechin gallate (EGCG) by using a dynamic axial compression column. The method comprises the following steps: taking a tea polyphenol extract as a raw material, and separating and purifying EGCG by using a dynamic axial compression column. The method can safely and efficiently prepare high-purity EGCG.

This invention discloses a near-infrared light-exciteable composite nanosheet, its preparation method, and its applications, belonging to the field of biomedical technology. The method includes the following steps: mixing epigallocatechin gallate with a Ti3C2 nanosheet dispersion, ultrasonically reacting, adding silver salt, and continuing stirring in the dark; after the reaction is complete, washing and separating to obtain MXene-EGCG@Ag composite nanosheets. The composite nanosheets provided by this invention possess near-infrared light-exciteable properties and can be used to prepare medically acceptable dosage forms such as hydrogels for the treatment of periodontitis. The preparation method provided by this invention is simple, the raw materials are readily available, and it exhibits significant antibacterial and anti-inflammatory effects, enabling further widespread application.

The application belongs to the field of coordination chemistry and analytical sensing technology, and particularly relates to a Zn(II)-Tb(III) complex ratio fluorescence sensor and a preparation method and application thereof. The sensor is a double-metal coordination polymer formed by coordination of Zn(II) ions, Tb(III) ions, nitrogen-containing organic ligands and carboxylic acid organic ligands. Under excitation conditions, the sensor simultaneously generates an emission signal of ligand coordination with Zn(II) and a characteristic emission signal of Tb(III) ions, forming intrinsic double emission. By monitoring the fluorescence intensity ratio (I395 / I549) of the two characteristic emission peaks at 395 nm and 549 nm, ratio fluorescence detection of propyl gallate can be realized, and the detection limit is as low as 0.35 μM. The sensor of the application has a simple synthesis method, a rapid detection process, and realizes internal calibration by using a ratio signal, has strong anti-interference ability, and is suitable for detection of propyl gallate in edible oil and other actual samples.

The present invention relates to a dermatological composition in an essentially liquid form, in particular in the form of a serum, comprising epigallocatechin gallate (EGCG) and ascorbic acid.

This invention discloses a method for determining the origin of tea based on the stable isotope ratio of EGCG monomers, belonging to the field of tea origin identification technology. It aims to solve the technical problem of insufficient accuracy in existing tea origin identification methods. The method involves measuring the overall stable isotope ratio δ in the tea sample. 13 C 茶叶 δ 15 N 茶叶 δ 2 H 茶叶 δ 18 O 茶叶 and the δ¹² value of stable isotope ratios of EGCG monomers 13 C EGCG δ 2 H EGCG and δ 18 O EGCG The preparation method of EGCG monomer involves making tea powder from tea samples, extracting and purifying epigallocatechin gallate (EGCG) monomer from the tea powder, and then determining the stable isotope ratio of the EGCG monomer. Based on the above stable isotope ratio, the origin of the tea sample is identified. This invention is mainly used for the accurate identification of tea origin, providing technical support for tea traceability and quality control.

The application discloses a method for promoting ovary development of Pelteobagrus vishnui, belongs to the technical field of fish culture, and feeds a functional additive during an ovary development preparation period and a strengthening period in the process of culturing Pelteobagrus vishnui, wherein the functional additive is a microcapsule prepared by mixing epigallocatechin gallate and a composite unsaturated fatty acid, embedding the inside layer by using beta-cyclodextrin, and coating the outside layer by using chitosan; and the composite unsaturated fatty acid is composed of monounsaturated fatty acid and polyunsaturated fatty acid at a volume ratio of 0.8-1:1-1.2. In the application, the EGCG and the composite unsaturated fatty acid are compounded, and then embedded to prepare the microcapsule, which is added into feed for feeding, so that the ovary development of Pelteobagrus vishnui is effectively promoted, the number of oocytes is increased, the proportion of III stage oocytes is increased, the fecundity of Pelteobagrus vishnui is effectively improved, and the spawning quantity, fertilization rate and hatching rate are increased.

This invention provides a ready-to-drink milk tea based on a ternary complex stabilized with κ-casein genotype and its preparation method, belonging to the field of dairy processing technology. It includes a ternary complex of casein micelles containing AA genotype κ-casein, epigallocatechin gallate, and fructose. The preparation of the ready-to-drink milk tea includes the following steps: S1: raw material screening and pretreatment; S2: preparation of the ternary complex; S3: blending and processing of the ready-to-drink milk tea. By screening AA genotype κ-casein raw milk and using a specific sequence of first compounding EGCG and then grafting fructose, a casein micelle-EGCG-fructose ternary complex with uniform structure and controllable particle size is constructed. Fructose is further grafted onto the surface of the complex through glycosylation, effectively masking the excessive binding sites of proteins and polyphenols, significantly inhibiting the formation of insoluble aggregates, thereby maintaining excellent colloidal stability of the product during its shelf life.

The present invention discloses a guarana extract – EGCG synergistic fat-burning composition, belonging to the technical field of functional foods and weight management. The composition comprises guarana extract, epigallocatechin gallate, and konjac glucomannan. By controlling the component ratio and key parameters, a dynamic gel network formed by konjac glucomannan provides in-situ protection of active ingredients and enables programmed release in the gastrointestinal tract, while constructing a multi-level appetite-suppression system with temporal continuity.The invention overcomes problems in the prior art, including poor stability, low bioavailability, and fragmented appetite regulation, and achieves synergistic effects in fat burning and intake control. It is suitable for preparing oral solid formulations, with high safety, good stability, and suitability for large-scale industrial production and commercialization.

This invention discloses an EGCG supramolecular compound with antioxidant, liver-protective, and fat-reducing effects, its preparation method, and composition. The supramolecular compound is formed by non-covalent bonding between epigallocatechin gallate (EGCG) and ligand molecules containing trimethylamine and carboxyl groups; the supramolecular compound has a co-amorphous structure; the ligand molecules containing trimethylamine and carboxyl groups are betaine, ergothioneine, or L-carnitine. This invention can solve the problems of low stability and bioavailability of EGCG. It can significantly improve the solubility of EGCG and its ligands, including betaine, L-carnitine, and ergothioneine, reduce the hygroscopicity of EGCG and its ligands, including betaine, L-carnitine, and ergothioneine, and enhance the stability and bioavailability of EGCG and its ligands, including betaine, L-carnitine, and ergothioneine.

This invention discloses a high oil-holding capacity and temperature-resistant oleogel and its preparation method, comprising dissolving a gelling agent in a base oil, dispersing it under magnetic heating, and obtaining the oleogel after cooling; wherein the gelling agent is composed of β-sitosterol and propyl gallate. This invention uses β-sitosterol and phenols as gelling agents to improve the types of dual gelling agents and enhance various properties of the oleogel; the entire preparation process is carried out under relatively mild temperature conditions, and by controlling the amount of β-sitosterol and phenols, the performance of the final oleogel can be effectively regulated to meet the needs of different application scenarios; this technical route does not involve hydrogenation, avoiding the generation of trans fatty acids; at the same time, it effectively reduces the calorific value of the oil and improves its oxidative stability and health benefits.

This invention discloses a tooth powder with whitening, stain removal, and anti-inflammatory effects, and its preparation method. The tooth powder is a compound of a whitening system, an antibacterial and anti-inflammatory system and a microbiome regulation system, a repair and abrasion system, and a taste-correcting and preservative system. Its core utilizes a specifically formulated biofilm complex enzyme, which can efficiently decompose dental plaque biofilm. Combined with sodium phytate and niacinamide, it achieves gentle whitening and stain removal; with epigallocatechin gallate and baicalin, it achieves targeted antibacterial and anti-inflammatory effects; with probiotic components, it regulates the oral microbiome; and with hydroxyapatite and 45S5 bioactive glass, it repairs tooth enamel. This invention employs customized embedding technology and a graded low-temperature preparation process, significantly improving the storage stability of the active ingredients. The tooth powder of this invention is gentle and non-irritating, does not damage tooth enamel, does not disrupt the oral microecological balance, and has multiple oral care effects with long-lasting and non-rebounding results, making it suitable for large-scale industrial production and long-term use by various population groups.

The application discloses a kind of metal-polyphenol hydrogel dressings preparation method and its application, it is related to the technical field of biomedical materials, first preparation specified proportion ethanol aqueous solution, gallus acid is dissolved with magnesium chloride ultrasonic, ammonia water is stirred and reacted, and solid crude product is collected by centrifugation.Washing and drying are carried out to obtain purified magnesium-gallus acid nanoparticles, which are dispersed and then added to methylacrylated gelatin and photoinitiator, filtered after constant-temperature dissolution.The filtrate is blue light crosslinking solidification, washing and ultraviolet double-side sterilization, then extracted by culture medium and filtered, to obtain metal-polyphenol hydrogel dressing and corresponding extract.The application can stabilize the structure of polyphenol, realize the controlled release of active substances, and avoid the toxicity caused by the rapid release of ions.The dressing can scavenge free radicals, inhibit inflammation, promote angiogenesis and tissue regeneration, has good biocompatibility, can maintain a moist environment for the wound, accelerate wound healing and reduce scar formation.

This invention provides the application of epigallocatechin gallate (EGCG) in the preparation of Bagaza virus helicase inhibitors or anti-Bagaza virus drugs, belonging to the field of pharmaceutical technology. Utilizing the crystal structure of BAGV helicase, molecular docking analysis shows that EGCG has a dual inhibitory effect on both the RNA binding site and NTP binding site of BAGV helicase, thereby precisely inhibiting helicase activity. Furthermore, ATPase activity testing results demonstrate that EGCG has a significant inhibitory effect on BAGV helicase, thus achieving the goal of anti-BAGV. This invention provides a feasible strategy for innovative BAGV therapies.

This invention discloses an interpenetrating network antibacterial hydrogel with angiogenesis function, its preparation method, and its applications. The hydrogel is formed by in-situ photocrosslinking of a precursor solution to create a three-dimensional interpenetrating network structure. The precursor solution comprises the following components by mass fraction: 0.5%–1.5% gallic acid-modified low-viscosity chitosan, 0.5%–1.5% decellularized liver matrix, 8%–12% methacrylic acid gelatin, 0.5%–1.0% photoinitiator, and the balance being phosphate-buffered saline. This invention uses low-viscosity chitosan as the modifying unit, combined with a strategy of precise acid adjustment before blending. This not only effectively avoids the risks of polymer phase separation and flocculation that are easily caused during multi-component blending, but also fundamentally solves the problem of the influence of the acidic microenvironment on the interpenetrating crosslinking of polymers. The precursor solution of this hydrogel has excellent fluidity, can precisely adapt to irregular defects, and can solidify rapidly in situ. It integrates antibacterial properties and induces angiogenesis, showing broad application prospects in the repair of complex skin tissues such as chronic diabetic wounds.

The invention relates to a pharmaceutical dosage form for oral administration comprising (i) an intragranular phase, which comprises Sertraline or a physiologically acceptable salt thereof; one or more intragranular fillers (preferably selected from one or more sugar alcohols or sugars; preferably mannitol or lactose, more preferably mannitol); one or more intragranular antioxidants (preferably selected from butylated hydroxytoluene (BHT), butylated hydroxy anisole (BHA), tocopherol or derivatives thereof, ascorbic acid or derivatives thereof, sodium metabisulphite, propyl gallate, sodium thiosulphate, or any combination thereof, more preferably ascorbic acid); (ii) an extragranular phase, which comprises one or more extragranular fillers (preferably mannitol, microcrystalline cellulose, lactose, or any combination thereof); and (iii) optionally, a film coating. The invention further relates to a process for manufacture by wet granulation, wherein the antioxidant is preferably dissolved in the granulation liquid.

Methods for selectively preparing monoglucosides of epigallocatechin and epigallocatechin gallate are provided, and the use of these products in cosmetics.

The invention belongs to the field of natural pharmaceutical chemistry and the field of cosmetics, and particularly relates to a skin care composition, a skin care product and application thereof.The skin care composition comprises silymarin, epigallocatechin gallate and quercetin, and the mass ratio of the silymarin to the epigallocatechin gallate to the quercetin is (3-7): (3-10): (1-5). The skin care product comprises the skin care composition, the content of the skin care composition is 0.5-10%, the skin care composition or the skin care product is applied to preparation of the skin care cosmetics, the esterified lecithin is used for encapsulating the silymarin, the epigallocatechin gallate and the quercetin, and sodium hyaluronate is matched, so that the skin care composition or the skin care product can be used for preparing the skin care cosmetics. The problems that flavonoid compounds are difficult to dissolve, permeate and absorb are effectively solved, and meanwhile, the skin care composition and sodium hyaluronate have a synergistic effect, so that the moisturizing, wrinkle removing and aging resisting effects are remarkably improved.

The application belongs to the technical field of oil sludge separating agents, and specifically provides an oil sludge separating agent and an oil sludge separating method, and the preparation steps include the following: taking propylene glycol block polyether, a coagulant and an oil capturing agent, stirring, and obtaining; the preparation steps of the oil capturing agent include the following: S01. Taking polycaprolactone, adding acetone to heat and disperse to obtain A liquid; S02. Taking hydroxypropyl-beta-cyclodextrin and propyl gallate, heating, adding water and stirring, then adjusting pH, adding ethylenediamine disuccinic acid, and continuing to stir to obtain B liquid; S03. Dropping A liquid into B liquid, maintaining stirring until mixing is complete, and then rotary evaporation to collect solid components to obtain. After the oil sludge is treated by the oil sludge separating agent and the separating method, the total oil removal rate of the oil sludge is greater than or equal to 92.5%.

This invention discloses a method for preparing and applying a Pasteurella-Bordetella nanovaccine, belonging to the field of biomedical technology. The method includes the following steps: emulsifying epigallocatechin gallate, an antigen aqueous phase, and soybean oil under high-speed shearing, followed by homogenization to form a stable oil-in-water emulsion, which is the Pasteurella-Bordetella nanovaccine. Challenge experiments confirmed that the ESO vaccine achieved a protection rate of up to 90% against Pasteurella multocida and Bordetella bronchiseptica, significantly superior to the 40%-70% protection rate of the aluminum adjuvant group. Simultaneously, it significantly reduced the bacterial load in the lungs, demonstrating excellent clinical protective effects. This invention, through the innovative combination of EGCG and vegetable oil, overcomes the limitations of traditional adjuvants in terms of immunogenicity, safety, and single function, providing a highly efficient and safe new vaccine solution for the prevention and control of Pasteurella multocida and Bordetella multocida infections.

This invention relates to a complex method for improving the solubility of hesperidin in concentrated orange juice, belonging to the field of food processing technology. Specifically, it relates to a technique that combines specific functional components and a physical field to efficiently and stably improve the solubility of hesperidin in concentrated orange juice. The main steps of this invention include: raw material selection, preparation of concentrated orange juice, preparation of a functional polysaccharide-EGCG composite cosolvent, addition of the functional polysaccharide-EGCG composite cosolvent, ultrasonic treatment, sterilization, static magnetic field-assisted cooling, and filling. The functional polysaccharide-EGCG composite cosolvent is synthesized by the self-assembly of functional polysaccharides and epigallocatechin gallate (EGCG); the static magnetic field-assisted cooling involves applying a low-temperature static magnetic field to the concentrated orange juice after pasteurization. Compared with concentrated orange juice prepared by untreated or single-treatment methods, this invention can significantly improve the solubility of hesperidin in concentrated orange juice, contributing to the quality improvement of such products.

This invention proposes a glass ionomer cement composite material with antibacterial and reinforcing functions and its application. The composite material includes a powder and a liquid. The powder includes 1-5 wt% supported hollow hydroxyapatite microspheres and the balance being fluoroaluminosilicate glass powder. The supported hollow hydroxyapatite microspheres are hollow hydroxyapatite microspheres supported with epigallocatechin gallate. By adding supported hollow hydroxyapatite microspheres, a mixed powder of glass ionomer cement with antibacterial and reinforcing functions is obtained. Without interfering with the normal curing process of glass ionomer cement, the antibacterial properties, compressive strength, and fluoride ion release performance of the material are significantly improved, while maintaining good biocompatibility. It is suitable for dental restoration, cavity filling, and caries prevention treatment, and has the potential for long-lasting antibacterial effects and promotion of tissue health. It is a novel dental restorative material with superior performance and strong clinical applicability.

Suitable thermoplastic compositions for use in rotational molding applications include a) a polyethylene composition having a melt index I2 of 0.5 to 10 g / 10 min and a melt flow rate of 0.930 to 0.965 g / cm³. 3 The density of; and b) the additive package. The additive package contains i) a first hindered phenolic antioxidant compound selected from d,l-α-tocopherol, d,l-β-tocopherol, d,l-γ-tocopherol, d,l-δ-tocopherol, propyl gallate (3,4,5-trihydroxybenzoate), and mixtures thereof; and ii) a first phosphite antioxidant compound having formula I: (I) wherein R 1 R 2 R 4 and R 5 Independently selected from hydrogen atoms and C1-C 12 Alkyl; R 3 Selected from hydrogen atoms and C1-C8 alkyl groups; L represents a single bond or has the formula -CHR 6 - alkylene groups, wherein R 6 It is a hydrogen atom or C1-C 12 Alkyl group; A is an alkyl group having the formula -CHR 7 - Alkylene, having the formula -C*(=O)CHR 7 - carbonyl group, where C * Bonded to O in formula I, or having a carbonyl group of formula -(C=O)-, wherein R 7 It is a hydrogen atom or C1-C 12 Alkyl; wherein one of Y and Z is selected from hydroxyl, alkoxy, aryloxy, alkylaryloxy, and arylalkoxy, and the other of Y and Z is selected from hydrogen and C1-C. 12 alkyl.

This invention belongs to the field of biopharmaceutical manufacturing technology and discloses an antioxidant and anti-aging PN complex and its preparation method, comprising: polydeoxyribonucleotide, epigallocatechin gallate, divalent magnesium ions, sodium ascorbate phosphate, citrate-sodium citrate buffer system, and water; the divalent magnesium ions form chelates with the phosphate groups on the polydeoxyribonucleotide molecular chain and the phenolic hydroxyl groups of epigallocatechin gallate, respectively, so that epigallocatechin gallate forms a continuously distributed molecular coating layer on the surface of the polydeoxyribonucleotide molecular chain; this invention solves the problem of heterogeneous gel aggregation caused by excessively fast reaction kinetics in the preparation of biopharmaceutical macromolecules by transforming the unavoidable disordered crosslinking between chains in conventional mixing processes into highly ordered intramolecular homogeneous encapsulation.

In one embodiment, the present application discloses, in part, biologically active compositions comprising a Crila® composition, or an admixture of Crinum latifolium L. dry extract (Crila®) and epigallocatechin gallate (EGCG), wherein the ratio of the Crinum latifolium L. dry extract to EGCG, and their use in the treatment of intramural or subserosal fibroids and various related diseases.

This invention provides a ternary composite material, its preparation method, and its application. The preparation method of the ternary composite material includes the following steps: (1) mixing sodium caseinate with epigallocatechin gallate to obtain a protein-polyphenol binary complex; (2) mixing the protein-polyphenol binary complex with tea polysaccharide to obtain a ternary composite material. This invention employs a molecular self-assembly strategy to construct an SC-EGCG binary composite system, utilizing the non-covalent interactions (hydrogen bonds, hydrophobic interactions, etc.) between tea polysaccharide (TPS) and the SC-EGCG complex to construct a stable SC-EGCG-TPS ternary composite system with a three-dimensional network structure.

This invention discloses a high-performance nano-electrospun membrane and its preparation method. The electrospinning solution of the nano-electrospun membrane comprises a synergistically modified polymer matrix material, an organic small molecule, polyethylene glycol, polyvinylpyrrolidone, Tween-80, zinc stearate, and a solvent. The synergistically modified polymer matrix material is based on polyacrylonitrile, and is prepared by introducing dopamine, 3,4-dihydroxyphenylethylamine hydrochloride, 3-aminopropyltriethoxysilane, and cerium nitrate in solution. The organic small molecule is propyl gallate. Through the synergistic effect of the components, the prepared nano-electrospun membrane exhibits high continuous film-forming stability, good structure retention during use, excellent environmental stability, and outstanding storage and reuse performance of the electrospinning solution. The method of this invention is stable, highly feasible, and suitable for the preparation and application of high-performance nano-electrospun membranes.

The application belongs to the technical field of biological medical material preparation, and provides a hydrogel, a preparation method and application thereof. The E-A powder is obtained by mixing the epigallocatechin gallate solution and the arginine solution, and then reacting under saturated water vapor at 121 DEG C to 134 DEG C, and drying the reaction solution. Then the E-A solution, the gelatin solution and the CMC solution are mixed, and then the copper salt is added, and the in-situ cross-linking is carried out to obtain the hydrogel. The hydrogel prepared by the application can realize long-acting and controllable release, reduce the nursing burden, and has a triple response phased function output. Meanwhile, the strong wet adhesion and self-healing of the hydrogel are more suitable for the skin and mucosa and other high-activity and high-humidity environments. In addition, the hydrogel can in-situ gel under physiological conditions, and has multi-form application. In application, the hydrogel has comprehensive comfort and economy, and has good popularization and economic feasibility in the clinical path.

The application discloses a novel dental nanocomposite material and a preparation method and application thereof, and the nanocomposite material comprises the following preparation raw materials in parts by weight: 15-30 parts of eucommia ulmoides derived antibacterial carbon dots-epigallocatechin gallate, 10-25 parts of iron nitrate, 5-7 parts of boric acid, 8-12 parts of metformin hydrochloride, 4-6.6 parts of zinc chloride, 40-60 parts of hyaluronic acid and 4-6 parts of 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid sodium. The application takes eucommia ulmoides derived antibacterial carbon dots-epigallocatechin gallate as a core, and through the o-benzenetriol structure of epigallocatechin gallate, a stable metal-phenol / boric acid ester hybrid network inner shell is cooperatively constructed with iron ions and boric acid, and the effect of synergistically improving anti-inflammatory and long-acting promotion of directional differentiation of dental pulp stem cells is achieved.