205 results about "Diabetic foot" patented technology

The invention discloses a diabetic foot early-stage detection method combining infrared and visible light imaging, and relates to the technical field of diabetic foot medical imaging diagnos.The diabetic foot early-stage detection method comprises the steps that multi-mode image collection and standardization processing are conducted, infrared images and visible light images are synchronously collected, and standardization processing such as size normalization is conducted; image registration and space alignment are carried out, marking points are set based on foot anatomical features, and feature extraction, mismatching point elimination and transformation matrix calculation are carried out; extracting and screening multi-dimensional features, extracting temperature and structural features, and screening by using a Relief-F algorithm; feature lesion recognition and classification are fused, and lesion probability is output through a double-branch convolutional neural network; carrying out detection result verification and feedback optimization, and comparing a clinical diagnosis optimization model; and generating a detection report and storing data, and generating a report containing the fused image. The early lesion detection precision is improved through multi-modal fusion, individual and environment differences are adjusted and adapted in a personalized mode, and reliable technical support is provided for clinic.

The invention discloses a local oxygen therapy, flushing and skin stretching device for chronic wound treatment, and relates to the technical field of medical apparatuses and instruments, the local oxygen therapy, flushing and skin stretching device comprises a stretching disc, and a cleaning device is arranged in the middle of the stretching disc; according to the device, breakthrough is achieved through the combination of the circular structure of the stretching disc and the circumferentially-distributed T-shaped sliding racks; the circular geometric structure of the stretching disc has stress symmetry, and stretching force can be evenly dispersed; the position of the T-shaped sliding rack installed in a circumferential sliding mode can be flexibly adjusted in the radial direction of the stretching disc, and six or more stretching points can be set at will according to the boundary of the wound surface in cooperation with the sliding block and the T-shaped hook frame which can slide. For example, for an irregular polygonal wound surface of a diabetic foot, a medical worker can mark six stress balance points on the T-shaped sliding rack and fix the hook, synchronous or independent adjustment of multiple distraction points is achieved through linkage of the rotating gear ring and the multiple sets of gears, and the situation that skin ischemia blister is caused by too large local stress or tissue stretching is affected by insufficient stress is avoided.

The invention relates to injectable temperature-sensitive hydrogel loaded with traditional Chinese medicine active exosomes, and belongs to the technical field of clinical treatment of diabetic foot refractory wounds, and the injectable temperature-sensitive hydrogel is obtained by poloxamer 407 hydrogel and a hyaluronic acid loaded composite carrier; the composite carrier body is formed by coating a traditional Chinese medicine active exosome with a coating solution; the traditional Chinese medicine active exosome is obtained by inducing adipose-derived mesenchymal stem cells with a modified astragalus extract. The injectable temperature-sensitive hydrogel is obtained by loading a composite carrier with poloxamer 407 hydrogel and hyaluronic acid, the poloxamer 407 and the hyaluronic acid quickly form a physical barrier on a wound surface after being injected, a moist healing environment is provided, and continuous and slow release of exosome and active ingredients is realized by means of the temperature-sensitive characteristic and the network structure of the poloxamer 407 and the hyaluronic acid, so that the wound healing effect is improved. And over-high local concentration or premature loss caused by sudden release of the medicine is avoided.

The invention relates to the technical field of non-invasive monitoring, in particular to a diabetes blood glucose fluctuation trend prediction method based on foot temperature and humidity change, which comprises the following steps: continuously collecting temperature, humidity and motion data of multiple areas of a foot through a foot wearable device, extracting a feature set related to blood glucose fluctuation from the preprocessed data, and calculating the blood glucose fluctuation trend according to the feature set; and fusing the feature set and context event information, inputting the fused feature set and context event information into a multi-task deep learning prediction model, visually displaying a prediction result in the forms of a trend arrow, a probability interval and a risk level, and triggering early warning in advance when a hyperglycemia or hypoglycemia event is predicted to be about to occur. The method is completely noninvasive and high in compliance, prospective trend prediction can be carried out based on existing diabetic foot monitoring wearable equipment, individual physiological characteristics of a user can be continuously learned through a built-in personalized self-adaptive mechanism, dynamic calibration is carried out on the model through incremental learning, and the prediction accuracy is improved. And the prediction precision is continuously improved along with the use time.

The invention relates to the technical field of big data processing, in particular to a temperature and humidity data dynamic calibration and compensation method for wearable medical equipment, and the method comprises the following steps: multi-parameter data synchronous acquisition, sweat evaporation cooling effect compensation, pressure-temperature sensitivity compensation, and dynamic baseline drift correction. The method further comprises abnormal value filtering based on physiological laws and cloud collaborative calibration. According to the method, high-precision dynamic compensation and calibration of temperature and humidity data are realized in a mode of combining multi-sensor cooperative sensing, physical mechanism modeling and dynamic baseline correction, so that the problem of data misalignment of wearable medical equipment in a complex use environment is solved; and a reliable technical support is provided for accurate monitoring and early intervention of diseases such as diabetic foot and the like.

The invention relates to the technical field of big data processing, in particular to a multi-source data fusion generation method for a diabetic foot health status assessment report, which comprises the following steps of: firstly, converging and preprocessing multi-modal heterogeneous data from wearable equipment, clinical input and historical records; the method comprises the following steps of: firstly, extracting data by using an attention mechanism-based deep learning network, then extracting deep correlation features among the data by using an attention mechanism-based deep learning network, then analyzing fusion features through a mixed decision engine combining rule reasoning and a machine learning model, generating structured risk assessment tags, and finally, dynamically calling parameterized templates by a system according to the tags, thereby realizing risk assessment. And a natural language generation technology is utilized to output an interactive visual evaluation report capable of performing personalized rendering according to a user role. According to the method, multi-source data can be automatically fused, deep analysis is carried out, a personalized, dynamic and interactive report is generated, and original and isolated monitoring data is converted into intelligent insight capable of guiding clinical actions.

This invention belongs to the field of medical device technology and discloses a foot pressure relief device for diabetic foot. It includes a base, a pressure relief plate and a motor connected to the base, and a foot pedal and a transmission assembly connected to the pressure relief plate. The transmission assembly includes a crank, a first connecting rod, and a sliding seat. The crank is fixedly connected to the output shaft of the motor, and the sliding seat is connected to the pressure relief plate. The two ends of the first connecting rod are respectively connected to the crank and the sliding seat. The sliding seat is connected to a foot rolling shaft and a second connecting rod, and the second connecting rod is connected to a foot massage roller. A buffer spring is provided between the pressure relief plate and the base. The foot pedal has a through groove, and the foot rolling shaft is connected to a foot massage roller. This invention utilizes the foot rolling shaft / foot massage roller and the foot massage roller to simultaneously perform rolling massage on the sole and instep of the foot. The periodic oscillation of the pressure relief plate causes the heel and toes to alternately rise, resulting in good pressure relief for the foot.

According to the application of the dipsacus asper saponin VI in regulating and controlling the differentiation of the surface stem cells, the brand new pharmacological action of the dipsacus asper saponin VI in targeted promotion of the differentiation of the epidermal stem cells is found for the first time, the cognitive limitation of the prior art is broken through, a brand new target spot and direction are provided for research and development of innovative drugs for wound repair, and the application of the dipsacus asper saponin VI in regulating and controlling the differentiation of the epidermal stem cells is realized. A medicine containing teasel saponin VI is adopted, epidermal stem cells are taken as a core target, wound reepithelialization is accelerated by promoting directional differentiation of the epidermal stem cells, the mechanism is clear, the targeting property is high, a core link capable of directly hitting wound healing is adopted, epidermal stem cell differentiation is regulated in a targeted manner, and meanwhile, the medicine has the synergistic effects of resisting inflammation and promoting angiogenesis; the obvious application potential is realized on refractory wounds such as diabetic feet and pressure sores.

The diabetic foot nursing box comprises an extensible box body, a top cover and a fixing assembly, the extensible box body comprises a shell and a base, the upper end face of the base is provided with a periphery which protrudes inwards and is matched with the inner wall of the shell, a storage bin is formed between the periphery and the base, and the top cover is arranged in the storage bin. The fixing assemblies are arranged on the front end face of the outer shell and the front end face of the top cover respectively and used for locking the outer shell and the top cover, positioning assemblies are symmetrically arranged at the left end and the right end of the outer shell and used for being positioned and unfolded in the box body, and therefore the outer shell and the base can be conveniently locked after the space is extended. And the storage bin can be extended by pulling the bottom plate downwards, so that the storage space is increased, and more articles can be conveniently stored.

The utility model relates to nursing instrument technical field, and disclose a kind of diabetic foot protection device, including protection device bottom pad, the top of protection device bottom pad is equipped with flexible protection body, the side of protection device bottom pad is equipped with rotating shaft, the side of rotating shaft is rotatably connected with hard protection body, the side of protection device bottom pad is fixedly connected with first connecting block, the side of hard protection body is fixedly connected with connecting plate, the top of first connecting block is equipped with the insertion slot, the top of connecting plate is fixedly connected with second connecting block, the one end of second connecting block is equipped with structure slot.The foot protection device for lower limb nursing of diabetic patient can make medical staff more conveniently observe and replace the wound dressing of affected side toe, help to prevent disease from getting worse, and improve the efficiency of nursing work, at the same time, it reduces the discomfort of patient suffered from repeatedly wearing protection device.

The invention discloses a diabetic foot prevention system and method based on immersive experience and artificial intelligence, and relates to the technical field of disease prevention, and the diabetic foot prevention system comprises an immersive interaction module, a multi-sensory stimulation module, a physiological monitoring module, an artificial intelligence module and a disease intervention module. The interactive 3D virtual scene is constructed through the immersive interaction module, the pathological evolution process of the diabetic foot is visually displayed, the problem that disease development is difficult to truly present in a traditional science popularization mode is solved, a diabetic patient is helped to deeply understand the pathogenesis, the evolution stage and the potential consequence of the disease, and the development of the diabetic foot is promoted. The foot disease state of the diabetic foot patient is simulated through the multi-sensory stimulation module, so that the diabetic patient experiences real symptoms such as pain and burning feeling, the fluke mind of the diabetic patient is broken, the foot health is actively concerned, and the diabetic foot risk is improved. And the risk of delay of the intervention opportunity due to light diseases is reduced.

The invention relates to the technical field of health management of diabetic foot high-risk patients, in particular to a foot sole monitoring method and system for diabetic patients based on the Internet of Things, and the system comprises a foot sole data acquisition module, a data analysis module, a dynamic correction module and a user interaction terminal. Pelma temperature, pressure and gait data are collected in real time through a sensor, abnormity is analyzed and risks are evaluated through a deep learning model, a personalized correction instruction is generated, the height of the insole and the gait angle are dynamically adjusted, and precise correction is achieved. The foot sole health state can be monitored in real time, the complication risk can be predicted, a personalized correction scheme is provided, the gait of a patient is effectively improved, the diabetic foot attack risk is reduced, and the life quality of the patient is improved.

The application discloses a kind of exercise monitoring management systems for diabetic foot patients, specifically relates to the field of diabetic patient monitoring, for solving the problem that existing exercise monitoring mode is difficult to effectively identify individualized risk trend and implement precise intervention;Through the pressure acquisition module, the main pressure area of the plantar under different gait is obtained, the pressure analysis module constructs the time sequence evolution track of the plantar stress direction, the electrical impedance acquisition module synchronously constructs the electrical impedance response sequence in the main pressure area of the plantar, the matrix construction module is jointly encoded into two-dimensional time sequence matrix of double channel, the lag extraction module analyzes the impedance lag area, the risk analysis module identifies the spatial overlap degree of impedance lag area and the main pressure area of the next cycle, the strategy construction module constructs risk trend turning point index with minimum point of coincidence degree and establishes individual exercise monitoring strategy based on different gait parameters, finally drives monitoring terminal to realize dynamic exercise intervention and prompt.

The specification relates to a method of manufacturing a diabetic foot patient-specific skin regeneration sheet, and a diabetic foot patient-specific skin regeneration sheet.

The diabetic rehabilitation shoe belongs to the technical field of diabetic foot shoes, comprises a first active adjusting rod group, an intermediate active adjusting rod group and a terminal active adjusting rod group, can actively adjust according to the walking posture of a wearer, overcomes the defects of the existing passive gait guide line, can collect the pressure of the wearer when using the shoe in real time, then compares with the preset gait guide line, when the deviation is large, can actively adjust in different regions, finally makes the walking posture of the wearer close to the normal walking posture, compared with the existing passive gait guide, the active correction purpose is achieved, and is suitable for the rehabilitation of diabetic patients.

The invention relates to an automatic diabetic foot liquid medicine spraying device which is characterized in that a foot face spraying head is arranged on the bottom face of a spraying cover, a toe spraying head is arranged on the inner end face of the spraying cover, an inclined supporting plate connected with the bottom of the spraying cover is fixedly installed at the bottom of a foot containing bin, and a plurality of supporting blocks are fixedly installed on the inclined supporting plate; the inclined supporting plate between every two adjacent supporting blocks is provided with a bottom nozzle, a waste liquid recovery tank is arranged on one side of the bottom of each supporting block, the bottom of each waste liquid recovery tank is connected with a waste liquid recovery barrel in the box body through a filter plate with liquid leakage holes, and a liquid supply box is arranged on one side of each waste liquid recovery barrel. The liquid supply box is communicated with the foot part spray head, the toe part spray head and the foot bottom spray head through a pipeline provided with a constant-pressure infusion pump; and targeted liquid medicine spraying can be completed, medical workers do not need to make contact with the feet of a patient, and the working efficiency and the operation efficiency are improved.

The utility model discloses a diabetic foot decompression device which comprises a bottom plate, a fixing frame is installed at one end of the top of the bottom plate, and when a movable block moves outside a threaded rod, cylindrical blocks at the two ends of the outside can be synchronously driven to slide inside a sliding groove; when the two cylindrical blocks slide, the two cylindrical blocks drive the adjusting plate to rotate through the supporting rods connected with the outer parts of the cylindrical blocks to adjust the angle, so that the diabetic patient can be massaged and decompressed when lying or sitting. On the basis that the foot angle of the pressure reduction operation can be adjusted, a specific massage pressure reduction mode is carried out according to the characteristics of the arch and toe areas, and meanwhile the temperature of the sole in the process can be detected.

The utility model discloses a diabetic foot decompression structure, which relates to the technical field of diabetes nursing and comprises a sole, a protective edge is sewn at the top of the sole, a protective belt is fixedly mounted at the top of the protective edge, a ventilation component is arranged in the sole, and a decompression component and the sole are arranged above the ventilation component. A protection edge is sewn to the top of the sole, a protection belt is fixedly installed at the top of the protection edge, a ventilation assembly is arranged in the sole, a pressure reduction assembly is arranged above the ventilation assembly, the surface of an air inlet pipe communicates with a first one-way valve, and a protection net plate is clamped to one end of the air inlet pipe. According to the foot pressure reduction structure of the diabetic foot, the ventilation assembly is arranged, in the using process, the foot of a patient extrudes the pressing plate at the bottom of the insole in the walking process, so that air in the air bag is exhausted into a cavity of a shoe, bacterium breeding is avoided, ventilation and pressure reduction of the foot are facilitated, and the service life of the patient is prolonged. And the subsequent recovery effect is facilitated.

The present application relates to a kind of skin grafting materials and its preparation and use method, which is composed of carrier sheet, anvil sheet and repair liquid, without skin adhesive;When using, cut skin dermis layer is attached to anvil sheet, put into medical leather rolling machine, and cut into microskin grafting;Spray repair liquid on the cut microskin grafting, transfer to carrier sheet, paste in the place to be grafted, separate aluminum foil and take down, wrap with gauze.The skin grafting material provided by the present application can reduce the damage to new granulation when removing skin grafting material, has the effects of antibacterial and anti-inflammatory, promoting repair and healing, promoting cell proliferation, providing scaffold for cell crawling, hemostasis, absorbing exudate, reducing scar formation and pigmentation, etc., can effectively accelerate epithelialization in skin grafting area;The effect after recovery is good, can be used for burn and scald, mechanical trauma, diabetic foot and other wounds, and has wide application prospect.

The invention discloses a post-amputation nursing device for diabetic feet. The post-amputation nursing device comprises a base, an arc-shaped supporting plate and a supporting soft cushion. The arc-shaped supporting plates are placed in arc-shaped containing grooves of the base, the left arc-shaped supporting plate and the right arc-shaped supporting plate are hollow arc-shaped supporting plates, a plurality of adjusting air cylinders are evenly distributed in grooves in the upper surfaces of the arc-shaped supporting plates, and the supporting soft cushion is placed on the arc-shaped supporting plates and composed of a plurality of air cushion units. The front side, close to the bottom, of the base extends forwards to form a sliding table, and a nursing mechanism is arranged on the sliding table. The post-amputation nursing device for the diabetic foot is placed below a post-amputation limb, the post-amputation limb of the diabetic foot is clamped under the condition that the post-amputation limb is evenly stressed through the mutual synergistic effect of the supporting plate driving air cylinder, the adjusting air cylinder, the air pump, the pneumatic electromagnetic valve and the gas electromagnetic distribution valve, and then the end of the post-amputation limb is effectively heightened; the wound surface is prevented from being contacted with the bed surface after the amputation of the urine foot, so that the injury caused by compression or friction is avoided.

The utility model relates to a simple-to-use dressing change stool for diabetic feet, which comprises a cylindrical body, a base is arranged at the lower end of the cylindrical body, and a plurality of traveling wheels with brakes are arranged at the bottom of the base; a garbage can is arranged in the cylindrical body, and a movable door is arranged on one side of the cylindrical body; the upper end of the cylindrical body is provided with an open slot for the feet of a patient to extend into the cylindrical body, the outer side surface of the cylindrical body is longitudinally and slidably provided with a U-shaped bracket and an adjusting assembly for adjusting the height position of the U-shaped bracket, and the U-shaped opening part of the U-shaped bracket is partially communicated with the open slot; during use, the feet of a patient extend into the opening of the cylindrical body through the opening groove and are supported by the U-shaped bracket, the splashing situation can be reduced, the height of the U-shaped bracket can be adjusted through the adjusting assembly, the comfort is improved, liquid obtained after cleaning is loaded by the garbage can, and cleaning is convenient. And the garbage can can be conveniently moved out for cleaning through the movable door on the side surface.

The application discloses a diabetes foot closed loop model construction method and system based on multi-source data, and belongs to the technical field of medical information technology and intelligent health management technology. Through a sensor terminal deployed on the patient side, a clinical information integration interface and a mobile detection device, multi-source heterogeneous data is synchronously collected. On this basis, a dynamic data structure body containing a main node and multiple sub-nodes is constructed, multi-source data is mapped to the corresponding sub-nodes according to a timestamp alignment rule, and a time sequence correlation graph is established in each sub-node. The system listens to the data stream in real time, adopts an incremental learning logic with a time decay factor to update the graph, and adjusts the weight parameters of other sub-nodes through an intervention response matrix according to a cross-node influence rule. The application provides support for risk assessment and pathological evolution analysis of diabetes foot by constructing a dynamically evolving data structure and a cross-dimension correlation mechanism.

The presently disclosed device is made up of a frame (2) that covers from the distal portion of the thigh of the affected extremity to the soles of the feet and has spacer rings inside (33-36-) of structures made of dry ice (carbon dioxide in a solid state, dry ice), memory foam, among others, atraumatic and non-allergenic when in contact with the user's skin, the frame (2) being divisible into at least two shells, anterior casing (4) and posterior casing (3) that are fixed together by means of a series of hooks for closing the casing (20-24), and the frame (2) having expandable upper and lower support bands (−5.29) of rubber that surround the extremity of the user; covered by a porous mesh (1).

The invention discloses a machine vision-assisted diabetes wound image noise suppression method and system, and relates to the technical field of medical imaging, and the method comprises the steps: extracting reflective image features of a reflective region of a diabetic foot wound image; analyzing and determining a reflection interference type; if the reflection interference type is percolate reflection, performing wound surface area calculation error prediction based on reflection image features; and formulating an adaptive image denoising mechanism according to the predicted area error, and performing reflective noise suppression processing on the diabetic foot wound image. The technical problem that an existing diabetic foot wound image noise suppression method cannot effectively solve interference caused by light reflection of a wound area, and consequently the calculation accuracy of the wound area is insufficient is solved.

The present application relates to the technical fields of diabetic foot treatment, and discloses a kind of diabetic foot auxiliary treatment device, including organism, treatment cavity is equipped in organism, and foot pedal is equipped in treatment cavity, and it is equipped with spray pool in front of foot pedal, and it is equipped with reflection boss in spray pool, foot sole flush nozzle, spray pool flush nozzle and atomization nozzle are installed on the inner wall of treatment cavity, and liquid storage tank is arranged in organism, water pump is communicated in liquid storage tank, main pipe is communicated in water pump, and main pipe is communicated with foot sole flush nozzle, spray pool flush nozzle and atomization nozzle by foot sole flush pipe, spray pool flush pipe and spray pipe respectively, electromagnetic valve is equipped on foot sole flush pipe, spray pool flush pipe and spray pipe, controller is electrically connected in electromagnetic valve, timer and touch screen are electrically connected in controller, and touch screen is arranged on the surface of organism.The present application can realize the auxiliary treatment of diabetic foot patient, to relieve the work burden of medical staff, while also can be used at home, help patient wound healing.

The utility model relates to the technical field of shoes for feet, and discloses a shoe for diabetic feet, which comprises a shoe body, an upper cover surface is movably connected to the outer surface of the upper end of the shoe body, an outsole component is fixedly connected to the outer surface of the lower end of the shoe body, and a handle ring is fixedly connected to the outer surface of the rear end of the shoe body. The upper cover face can cover the upper end of the shoe body, the first fixing piece and the second fixing piece can be pasted to the upper end surface of the shoe body through the hook-and-loop fasteners, a patient can use the shoe conveniently, the covering tightness of the upper cover face can be controlled, the size of the inner space of the shoe can be adjusted conveniently, and the shoe is convenient to use. The movable upper cover face can enable the interior of the shoe to have a good ventilation effect, the phenomenon that bacteria are prone to breeding due to the fact that the foot is stuffy in the shoe can be avoided, the arc-shaped bearing strips arranged in the inner cavity of the upper cover face can play a certain supporting role in the upper cover face, the upper cover face can be prevented from pressing the instep, and a better use prospect can be brought.

This invention discloses an integrated device for foot wound care and treatment in diabetic foot, relating to the field of medical device technology. It includes: a cleaning mechanism for removing necrotic tissue, bacteria, and secretions adhering to the wound surface; and a medication application mechanism that maintains contact between the sole of the foot and the medication layer, subsequently adhering an adhesion layer to the ankle. This invention achieves an integrated design for the foot wound care and treatment process, organically combining cleaning, disinfection, dressing changes, and auxiliary treatments within a single device. Medical staff no longer need to frequently switch between various instruments to complete different care and treatment steps, greatly simplifying the process. This saves time and effort while significantly improving overall work efficiency, providing higher quality and efficiency assurance for the care and treatment of diabetic foot patients, promoting wound healing, and accelerating the recovery process.

The invention belongs to the technical field of diabetic foot flushing, and particularly relates to a diabetic foot infected wound flushing device which comprises a collecting tank, the collecting tank is hollow, the hollow portion of the collecting tank is communicated with an external negative pressure machine through an air pipe, and the hollow portion of the collecting tank is fixedly communicated with a binding bag through an air pipe; the binding bag is fixedly communicated with a connecting pipe, the top end of the connecting pipe is fixedly communicated with an infusion pipe, the top end of the infusion pipe is fixedly communicated with a timing pipe, the top end of the timing pipe is fixedly communicated with a filter, and the top end of the filter is communicated with an infusion bag through the infusion pipe. Stable negative pressure generated by the negative pressure machine in the binding bag is used as core power, full-automatic starting, stopping and circulation of flushing are achieved, and the negative pressure is not only used for extracting flushing waste liquid and providing a negative pressure treatment environment for a wound surface, but also can drive a timing switch of the electromagnetic switch and drive the spiral blade to move in the infusion tube.

The invention discloses a deuterium-depleted water composition containing plant exosomes as well as a preparation method and application of the deuterium-depleted water composition, and the deuterium-depleted water composition is prepared from the following raw materials in parts by weight: 3-18 parts of a prebiotic compound, 3-20 parts of a modified exosome composition, 1-7 parts of sodium alginate and 35-120 parts of deuterium-depleted water, wherein the modified exosome composition is prepared from the following raw materials: 1 to 10 parts of exosome composition, 0.5 to 7 parts of folium mori flavone, 0.5 to 5 parts of nano-selenium and 1 to 10 parts of trehalose. The invention relates to a deuterium-depleted water composition containing plant exosomes, in particular to a synergistic composition of plant-derived exosomes and deuterium-depleted water, which is used for enhancing the biological activity of the plant-derived exosomes and the deuterium-depleted water, and can be used for metabolic regulation of diseases such as hypertension, hyperglycemia, hyperlipidemia (three highs), cirrhosis and diabetic foot by combining with a prebiotic fiber compound and a mulberry leaf flavone-nano-selenium compound.