630 results about "Diabetic foot" patented technology

A self-powered compression device for use in promoting circulation, said device embodying a plurality of inflatable sleeves arranged sequentially for applying compression to a body or limb and which further comprises a pump, a piping system and a bandage or boot to enclose the device in its entirety. A method for using self-generated pressure in promoting circulation in conditions including but not limited to, lymphatic and traumatic edemas, venous disorders, limb ulcers, varicose veins, muscle fatigue, sports medicine, cellulite treatment, diabetic feet, feet massage for recreation or cosmetic enhancements.

The invention relates to an active wound repair material, specifically to a functional dressing and a preparation method and application thereof, belonging to the field of medical materials. To overcome a technical problem, the invention provides the functional dressing, which belongs to biologically active wound repair materials. The functional dressing is prepared from the following raw materials by weight: 2 to 6 parts of biologically active glass, 12 to 20 parts of alginate, 4 to 12 parts of chitosan and 100 to 200 parts of water. Multiple dosage forms can be prepared from the above-mentioned raw materials, mainly comprising a gel, a dressing, etc. The functional dressing provided by the invention has the advantages of bacteriostatic action on a wound, promotion of wound healing and growth, adsorption of a small amount of tissue exudates, good biosecurity, waterproof performance, a bacterium blocking effect, etc. The functional dressing has a wide application scope, is applicable to mechanical trauma and operative incision (wound) and exerts a good therapeutic effect on hard-healing wounds like burns and scalds, diabetic foot, ulcer and pressure sores and a good curative effect on an infectious wound and a delayed union wound.

Methods and apparatus are provided for identifying and minimizing neurovascular contributions to determinations of endothelial function, including by digital temperature monitoring such that an accurate status of vascular reactivity can be obtained. Methods are also provided for identifying individuals having increased sympathetic nervous system activity impacting peripheral vascular function as well as for determining a status of diabetic foot.

The invention discloses a medicinal composition for treating diabetes. The medicinal composition consists of astragalus, gardenia, Szechuan lovage rhizome, siberian solomonseal rhizome, finger citron, root of red-rooted salvia, cinnamomvine, swordlike atractylodes rhizome, white paeony root, perilla fruit, kudzuvine root, fragrant solomonseal rhizome, oyster shell, rehmannia root, Chinese angelica, common anemarrhena rhizome, honeysuckle flower, heartleaf houttuynia herb, fresh imperata root, Chinese caterpillar fungus, semen nelumbinis, siberian solomonseal rhizome, cornus fruit, prepared rehmannia root, villous amomum fruit, liquoric root, medlar, asparagus, black sesame, tuckahoe, cherokee rose fruit, cistanche deserticola, angelica dahurica, adenophora, dark plum fruit, complanate astragalus seed, cassia seed, mulberry leaf, fresh reed rhizome, mint, oriental waterplantain rhizome, wrinkled gianthyssop herb and parslane herb. The medicinal composition can control the blood sugar level of various patients who suffer from the diabetes and improve the clinical symptoms of diabetes complications effectively. Therefore the medicinal composition can be used for treating the diabetesand the diabetes complications such as diabetic gastroparesis, diabetic nephroma, diabetic foot, diabetic neuropathy, diabetic eye diseases and diabetic pruritus and the like.

The invention discloses a medicinal composition for treating skin injury and ulcer diseases, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and Chinesemedicaments for clearing heat and releasing toxin such as coptis root, golden cypress bark, rhubarb, giant knotweed rhizome, honeysuckle flower, forsythia fruit and the like which are prepared into aplurality of dosage forms by matching the prior art. The technology overcomes the defects that the prior common preparations for the trauma department have extremely slow response, longer treatment course, adhesion with the skin, influence on scab cicatrization and the like, has quick and remarkable treatment effect on various skin diabrosis diseases such as mechanical wound, burn/scald, bedsore,chronic leg ulcer, diabetic foot or cancerous ulcer and the like, and can greatly shorten the required time for wound healing and tissue repair.

An individualized design method for a diabetic foot shoe pad comprises the steps that firstly, a general foot bone model is established, then key size data of the diseased foot is acquired, the general foot bone model is scaled to obtain an individualized bone model of the diseased foot, then three-dimensional data of surface appearance of the diseased foot is acquired and is coupled with the individualized bone model, and assembly is performed in CAN software to obtain an individualized three-dimensional model of the diseased foot; then, based on the three-dimensional model of the foot, a diabetic foot shoe pad base model completely fit with the foot is established according to foot bottom appearance characteristics and is imported into finite element analysis software with the three-dimensional model of the foot to perform assembly and grid partitioning, a finite element model of a foot-shoe pad is obtained, then a stress distribution result is analyzed and calculated, the modulus and structures of zones of the diabetic foot shoe pad base model are modified to form a final diabetic foot shoe pad model. The designed shoe pad meets the individualized demand, meanwhile a product design period is shortened, and the cost is reduced.

The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-injectable pharmaceutical composition which is administered by means of infiltration into and around chronic cutaneous ischaemic lesions in order to prevent diabetic foot amputation. Said composition can be administered to recently-created surgical surfaces damaged by the effect of acute reperfusion with oxygenated blood following prolonged ischaemia, thereby preventing further surgical procedures and favouring the preservation of the extremity. The aforementioned composition can be used to improve (i) the cell microenvironment, thereby increasing the reparative and defensive capacity and viability of the is tissues and (ii) the cicatrisation of cutaneous ischaemic lesions, thereby stimulating cell proliferation. The invention is suitable for use in human, veterinary and experimental medicine, specifically in vascular angiology and surgery, dermatology, burn treatment and reconstructive surgery and geriatric medicine. Said composition can be used for recalcitrant ulcers which are associated with lesions in the macro and/or microvasculature, patients with inadequate lymphatic and/or venous return and ulcers or other lesions which are difficult to cicatrise and/or heal.

The invention describes a device and a method for examining the sole of a foot. This invention can be used, for example, for the early detection of neuropathy and/or small wounds on the sole of the feet of diabetic patients. The device comprises a sending means for transmitting images of the sole to, for example, a doctor in a hospital. This enables rapid and simple recording of an image of the sole at home, and using relatively simple means, its transmission to, and examination by an expert at a remote location.

A method of treating a diabetic foot or leg ulcer comprising the steps of placing a pair of electrodes placed spaced apart in the region of a diabetic foot or leg ulcer and applying a predetermined sequence of current waveforms across the electrodes. The sequence of current waveforms comprises a first waveform comprising a series of current pulses having an amplitude in a range of from 80 to 300 μA, having a frequency in a range from 0.5 to 1.5 pulses per second and a pulse width in a range from 333 to 1000 ms, a second waveform comprising a series of current pulses having an amplitude in a range of from 20 to 60 μA, having a frequency in a range from 2 to 4 pulses per second and a pulse width in a range from 125 to 250 ms and a third waveform comprising a series of current pulses having an amplitude in a range of from 250 to 640 μA, having a frequency in a range of from 80 to 120 pulses per second and a pulse width in a range from 4 to 6 ms. The electrodes may be placed in the region of the diabetic foot or leg ulcer in a manner that is compatible with the application of an off-loading boot or cast.

The invention relates to an external gel used for treating diabetic foot, and a preparation method and an application thereof. Specifically, the invention relates to an external gel preparation with oxygen-carrying and antibacterial materials, and containing recombinant human epidermal growth factor (rhEGF). The preparation basically comprises: a medicine component recombinant human epidermal growth factor (rhEGF), an oxygen-carrying material, an antibacterial material, a gel substrate, a stabilizing agent, a humectant, a penetration enhancing agent, a surfactant, and a pH regulation agent.

The invention belongs to the field of medical dressings, and particularly relates to glass wound repair gel with biological activity and a preparation method thereof. The gel is prepared from, by weight, 10-40 parts of biological activity glass powder, 2-10 parts of polyethylene glycol 400, 10-25 parts of silica gel, 5-15 parts of sodium hyaluronate gel, 0.1-2 parts of acid particles, 0.5-5 parts of borneol and 0.1-0.5 part of absolute ethyl alcohol. The gel has remarkable treatment effects on treatment of chronic large-area wounds of empyrosis, pressure sores, diabetic feet, contusion, various skin surface anabrosis and the like, and meanwhile the gel has the special effects of preventing adhesion, resisting bacteria, preserving moisture, restraining scar growth and the like.

The invention discloses an exercise device used by a diabetic foot patient. The device comprises a lifting base, driving devices and foot fixing parts, wherein the number of the driving devices is two, the driving devices are symmetrically installed on the two sides of the upper part of the lifting base, the number of the foot fixing parts is two, and the foot fixing parts are in transmission connection with the two driving devices respectively. The device has the effects of promoting blood circulation of the feet of the diabetic foot patient, improving the conditions of the diabetic foot patient and benefiting rehabilitation of the diabetic foot patient, and meanwhile, the lower parts of the shanks of the diabetic foot patient can be fixed into grooves in the upper parts of supporting boards, so that it is avoided that the feet of the diabetic foot patient are fixed directly, and pain of the patient is avoided; moreover, through an operation handle, the height of the lifting base canbe conveniently adjusted so that the exercise device can be suitable for diabetic foot patients with different heights, and thus the device is worthy of promotion and popularization.

The invention discloses ozonized borneol tea oil. The ozonized borneol tea oil comprises ozone, borneol and tea oil; the tea oil per 1L includes 30 to 50g of borneol; the total input of ozone in tea oil per 1L is controlled to be 13.5 to 20.0g under temperature of 25 to 30 DEG C and pressure of 0.5 to 1.5bar. According to the ozonized borneol tea oil, the raw materials are cheap and easy to be obtained, the antibacterial effect can be obviously improved, the effects of diminishing inflammation, relieving pain and sterilizing are great, the wound healing is effectively promoted, the recovery of patients is sped up, a patient can easily accept, the ozone can be stably and slowly released, escherichia coli, staphylococcus aureus, candida albicans and the like can be eliminated within a short time, and good effect is particularly shown on treating chronic wounds like diabetic foot and acute wounds.

The invention discloses a medicinal composition for treating skin injury and ulcer diseases, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and Chinesemedicaments for activating blood and dissolving stasis such as angelica, Szechuan lovage rhizome, salvia root and the like which are prepared into a plurality of dosage forms by matching the prior art. The technology overcomes the defects that the prior common preparations for the trauma department have extremely slow response, longer treatment course, adhesion with the skin, influence on scab cicatrization and the like, has quick and remarkable treatment effect on various skin diabrosis diseases such as mechanical wound, burn/scald, bedsore, chronic leg ulcer, diabetic foot or cancerous ulcerand the like, and can greatly shorten the required time for wound healing and tissue repair and relieve pains of patients.

The invention provides a traditional Chinese medicine for curing diabetic foot, in particular a prescription curing diabetic feet of patients having different courses of the disease and different symptoms by stages. The traditional Chinese medicine is prepared from astragalus root, leatherleaf milletia, white peony root, cassia twig, achyranthes root, red sage root, mulberry twigs, Chinese angelica root, licorice, chuanxiong rhizome, ricepaper pith, asarum herb, sweetgum fruit, dried ginger, prepared rehmannia root, antler gelatin, Chinese ephedra, white mustard seed, Chinese date and other Chinese herbs. The prescription has the advantages that the price is low, the applicability is high, no toxic or side effects are caused, and the like. Successful development of the traditional Chinese medicine fills the gap in the field of medicament for curing diabetic feet, and the traditional Chinese medicine is proved to have good effects through clinical application. When in use, the traditional Chinese medicine can be selectively used according to medical histories and symptoms of the patients, so that symptomatic treatment is realized, the traditional Chinese medicine brings good news for the diabetic foot patients, the disease can be relieved without amputation, and the suffering of 'sugar poison' is eliminated.

The invention discloses a traditional Chinese medicinal composition for treating cold dampness blood stasis blocking channel type diabetic feet. The composition comprises oral medicines and external medicines, wherein the oral medicines comprise Peach Seed, Chinese angelica, Radix Astragali, Radix Codonopsis, Salvia miltiorrhiza, Chinese cassia, Rhizoma Atractylodis Macrocephalae, Poria cocos, epimeddium, prepared Polygonum multiflorum Thunb, Radix Polygalae, safflower, Ligusticum wallichii, rehmanniae radix, Millettia dielsiana, Chinese gall and lumbricus; and the external medicines comprise Chinese prickly ash, Radix Clematidis, Viciaamoena Fisch, Boswellia carteri, myrrh, Rheum officinale, Amur Corktree Bark, Folium Artemisiae Argyi, Ilex pubescens, fried Radix Sanguisorbae, safflower, talcum powder and Bletilla striata. The cold dampness blood stasis blocking channel type diabetic feet most appear in patients suffering the early-stage diabetic feet, and the main symptoms of the cold dampness blood stasis blocking channel type diabetic feet comprise warm liking, chill sensation, and cold, hemp and painful abnormal feels of affected limbs, intermittent claudication, foot skin dryness, hair shedding, food skin paleness during lower limp raising, skin purple during lower limp sagging, light tongue nature and white tongue fur. The traditional Chinese medicinal materials adopted in the invention has the different medical properties of qi and blood benefiting, blood circulation promoting and blood stasis removing, and inflammation removing and flesh engendering. On one hand, the local micro-vascular impairment of the lower limbs is improved and the blood circulation is promoted to make necrotic tissues shed as fast as possible in order to reach tissue restoration; and on the other hand, the oral medicines can effectively control the blood sugar, adjust the blood viscosity and reduce the blood pressure; and simultaneously the food infection is prevented to enhance the body immunity.

The invention discloses oxygen-microbubble-containing hydrogel for treating diabetic feet. The hydrogel comprises heparin-poloxamer polymer gel, cell growth factors and phospholipid vitamin E composite membrane microbubbles. The preparation method of the hydrogel disclosed by the invention comprises the following steps of (1) putting freeze-dry powder of the phospholipid vitamin E composite membrane microbubbles into a vial fully filled with oxygen, and performing sealing; (2) dissolving the cell growth factors to form a cell growth factor solution, and injecting the cell growth factor solution into the vial to form an oxygen coated phospholipid vitamin E composite membrane microbubble solution; and (3) dissolving heparin-poloxamer polymers by water to form the heparin-poloxamer polymer gel, and adding the heparin-poloxamer polymer gel into the microbubble solution in step (2) to form the oxygen-microbubble-containing hydrogel. The invention also discloses a purpose of the hydrogel toultrasonic gel preparation equipment and reagents.

The invention provides a preparation method of a gel containing a fibroblast growth factor-1 modified body and an application thereof for treating chronic skin ulcer caused by diabetic foot. The gel disclosed by the invention comprises the following components: 20000-80000 IU of recombinant human fibroblast growth factor-1 modified body (FGF-1135) protein, 10 pg to 40 mu g of low molecular weight heparin sodium, 0.2-1.0 g of glycerol, 50-150 mg of a protein protectant, and 0.03-0.05g of a gel substrate, wherein the pH value is adjusted; and water for injection is added to be 10 ml. Compared with the original sequence, the fibroblast growth factor-1 modified body used in the invention is more steady; after being prepared into the gel, the fibroblast growth factor-1 modified body is more convenient for clinical application; the better stability and slow-release effects can be achieved; the bioavailability of protein is increased; the gel is more beneficial to treating diabetic foot; and the gel can be also used for treating burning, scalding and other chronic and refractory ulcers.

The invention belongs to the field of traditional Chinese medicines (TCMs) and discloses a TCM composition and application thereof. The composition comprises the following TCMs in parts by weight: 0.11-97.0 parts of musk, 10.0-50.0 parts of gypsum, 0.05-10.0 parts of borneol, 5.0-15.0 parts of pseudo-ginseng, 4.5-9.0 parts of cuttlebone, 3.0-9.0 parts of silkworm cocoons, 3.0-6.0 parts of human urine sediment, 4.0-80.0 parts of calcined gypsum, 0.5-25.0 parts of pearls, 2.0-12.0 parts of frankincense, 2.0-12.0 parts of myrrh, 1.0-10.0 parts of sanguis draconis, 1.0-10.0 parts of rhizoma coptidis, 3.0-20.0 parts of horseshoe crab shells, 0.2-2.0 parts of dragon bones, 9.0-30.0 parts of oysters and 0.5-15.0 parts of carbonized human hair. The TCM composition has the functions of clearing away heat and toxic materials, activating blood circulation to dissipate blood stasis, carrying out sterilization to diminish inflammation, relieving pains, diminishing swelling and promoting granulation, inducing astringency and stopping slippage and astringing dampness and carrying out astringency. The TCM composition can be used for preparing the medicines for treating bedsore, ecthyma, scrofula sore, hemorrhoids, burns, scalds, tympanitis or diabetic foot.

The invention provides a Chinese medicinal preparation for treating diabetes and angiitis ulcer, wherein the medicament comprises the following raw material herbs (by weight portion):orange osmanthus 15-25 parts, frank incense 10-20 parts, astragalus root 25-35 parts, honeysuckle flower 55-65 parts, ragwort 7-17 parts, licorice root 25-35 parts, figwort 25-35 parts, borneol 35-45 parts,prepared dark Japanese plum 5-15 parts, alum 15-25 parts, bee wax 45-55 parts, root of achyranthes 10-20 parts, red sage root 15-25 parts, saffron 25-35 parts, rhizome of Sichuan lovage 10-20 parts, and radix paeoniae rubrathe 15-25 parts.

The invention provides a preparation method of animal skin acellular matrix dressing. The preparation method comprises the following steps: a step of inactivation of virus, a degreasing step, an unhairing step and a decellularizing step on split-thickness skin of animal skin, wherein the decellularizing step comprises multiple freeze thawing steps and a decellularizing step by a decellularizing solution after the multiple freeze thawing steps. The invention also provides the animal skin acellular matrix dressing prepared by the preparation method. By means of a decellularizing step combining a physical method and a chemical method, netty structures of elastic fibers and collagens of an extracellular matrix are retained to the maximum extent, and meanwhile, antigens are thoroughly removed. The acellular dermal matrix dressing obtained by the preparation method is permeable and ventilating, can provide a moist micro-environment for the wound, remarkably reduces the rejection reaction of heterogeneity, allows reproliferation of cells, shortens the healing time, reduces cicatricial formation, is convenient to apply, and can be applied to the fields of burn and scale treatment, chronic wound healing, diabetic foot treatment and the like.

The invention discloses a prepared traditional Chinese medicinal preparation for treating diabetes which is prepared from the following Chinese herbs, astragalus root, honey-suckle stem, oriental water plantain rhizome, Chinese angelica root, root of red rooted saliva, mulberry, Chinese honey locust and dahurian angelica root.

The invention relates to a slow-releasing agent of antibiotics containing aminoglycoside, comprising slow-releasing micro-sphere containing slow-releasing findings and aminoglycoside antibiotics, and special dissolvent containing suspending adjuvant agent such as sodium carboxymethyl cellulose with the adhesive degree being 100cp-3000cp (at 20-30 Deg. C). The slow-releasing findings comprises EVAc, polyphenyl, PLA, PLGA, decanedioic acid copolymer, albumen glue and gelatin; the slow-releasing micro-sphere can be produced to slow-releasing implanting agent and unguent agent. When the slow-releasing implanting agent and injection is placed or injected into bacteria, the medicine can be released slowly for more than 5-30 days, and toxicity is dramatically reduced at the same time when effective medicine concentration is got and maintained. The said slow-releasing agent is specially effective for chronic medullitis, bedsore, intractable ulcer on skin, diabetes femoral head necrosis and other abscessus, which are caused by Staphylococcus, Streptococcus, Streptococcus, acne Propionibacteriaceae, Enterobacter, Enterobacter, gonotoxin or parameningococcus.