3313results about "Laboratory analysis data" patented technology

A federated distributed computational system enables secure biological data analysis and genomic medicine with enhanced oncological therapy capabilities. The system implements patient-specific tumor-on-a-chip analysis through microfluidic control systems and cellular heterogeneity preservation, while integrating fluorescence-enhanced diagnostics using CRISPR-LNP targeting and robotic surgical navigation. The architecture coordinates spatiotemporal analysis of gene therapy delivery through molecular imaging and immune response tracking, and implements bridge RNA integration with multi-target synchronization. Treatment selection is optimized through multi-criteria scoring and patient-specific simulation modeling. Each federated node contains a local processing unit for biological data analysis, privacy preservation protocols, and a hierarchical knowledge graph structure. The system implements cross-species genetic analysis, environmental response modeling, and multi-scale tensor-based data integration, enabling research institutions to collaborate on complex, large-scale biological analyses while maintaining strict data privacy controls.

A federated distributed computational system enables secure oncological therapy optimization through robotic integration. The system establishes a distributed graph architecture with secure communication channels connecting computational nodes, implementing encryption protocols for cross-institutional data exchange. Each node contains processing capabilities for fluorescence-guided imaging, uncertainty quantification, and expert knowledge integration while maintaining hierarchical knowledge graphs of oncological biomarkers, interventions, and outcomes. The system coordinates domain-specific knowledge through token-space communication and implements an advanced robotic integration system for surgical interventions using spatiotemporal tumor mapping, multi-modal fluorescence imaging, surgical robot coordination, and space-time stabilized mesh management. Key capabilities include wavelength-specific multi-modal fluorescence detection, combined epistemic and aleatoric uncertainty estimation, tensor-based data integration with adaptive dimensionality control, and light cone search for adaptive treatment optimization—all while maintaining strict privacy controls.

The invention relates to a method convenient for data consanguinity collection and analysis, which comprises the following steps of: obtaining original consanguinity data comprising a task execution log, application metadata and a cross-system dependency relationship, and carrying out standardization processing on the original consanguinity data to generate structured consanguinity information comprising an asset unique identifier, an upstream and downstream association relationship and a data operation type; structured consanguinity information is synchronously written into a graph database and a distributed data warehouse, the graph database stores real-time association topology, the distributed data warehouse stores full-amount historical versions, and a transaction consistency algorithm is adopted to ensure the atomicity of double-write operation, so that the data storage efficiency is improved. Single-asset-level consanguinity tracking is performed based on real-time topology of a graph database, global consanguinity analysis is performed based on batch computing power of a distributed data warehouse, a direct dependence path, a deep association network and a closed-loop link detection result are generated, and a closed-loop management mechanism from data acquisition, analysis to optimization is formed. And the problem that an analysis result is disjointed from an acquisition end in a traditional scheme is solved.

A federated distributed computational system enables secure oncological therapy optimization through multi-expert integration and advanced uncertainty quantification. The system implements a multi-expert integration framework that coordinates domain-specific knowledge through token-space communication for precision oncological treatment, while maintaining secure cross-institutional data exchange. The architecture coordinates multi-scale spatiotemporal synchronization across computational nodes, with each node containing local processing capabilities for fluorescence-guided imaging, uncertainty quantification, and expert knowledge integration. Through a distributed graph architecture, the system enables advanced fluorescence imaging with wavelength-specific targeting, multi-level uncertainty estimation combining epistemic and aleatoric approaches, and multi-scale tensor-based integration with adaptive dimensionality control. The system implements light cone search and planning for adaptive treatment strategy optimization, enabling medical institutions and research organizations to collaborate on complex oncological therapy projects while maintaining strict data privacy controls.

A federated distributed computational system enables secure biological data analysis and genomic medicine through hybrid simulation capabilities. The system implements a hybrid simulation orchestrator that coordinates classical numerical simulations with machine learning models for biological system analysis, while maintaining secure cross-institutional data exchange. The architecture coordinates multi-scale spatiotemporal synchronization across computational nodes, with each node containing local processing capabilities for biological data analysis and privacy preservation protocols. The system implements cellular machinery assembly analysis, real-time patient data integration, and multi-modal image integration with spatiotemporal health data annotation. Through a distributed graph architecture, the system enables cross-species genetic analysis, environmental response modeling, and multi-scale tensor-based data integration with adaptive dimensionality control. The system implements real-time therapeutic response prediction through multi-modal data analysis, enabling research institutions to collaborate on complex biological analyses while maintaining strict data privacy controls.

The invention relates to the technical field of medical data processing systems, in particular to an artificial intelligence-driven medical diagnosis and treatment data processing method and system. The method comprises the steps that a multi-modal medical data acquisition module acquires and processes multi-source heterogeneous medical data of a patient, and a standardized data set is generated; a medical feature depth extraction module performs multi-dimensional feature extraction on the data set, and constructs a dynamic evolution feature matrix; a multi-dimensional health state space construction module constructs a patient health state multi-dimensional space according to the matrix and determines a key medical early warning index set; the real-time medical data fusion module maps real-time data to the space to generate real-time health risk factors; and the medical risk prediction and decision-making module establishes a personalized model, outputs a disease occurrence probability and generates personalized treatment suggestions. The system solves the problems that medical data processing is difficult, diagnosis analysis is not comprehensive, and a treatment scheme lacks personality, and diagnosis accuracy and treatment pertinence are improved.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Systems and methods are disclosed for informing and monitoring blood flow calculations with user-specific activity data, including sensor data. One method includes receiving or accessing a user-specific anatomical model and a first set of physiological characteristics of a user; calculating a first value of a blood flow metric of the user based on the user-specific anatomical model and the first set of physiological characteristics; receiving or calculating a second set of physiological characteristics of the user by accessing or receiving sensor data of the user's blood flow and / or sensor data of the user's physiological characteristics; and calculating second value of the blood flow metric of the user based on the user-specific anatomical model and the second set of physiological characteristics of the user.

The invention relates to the technical field of medical diagnosis, and discloses a DCM early noninvasive analysis method based on multi-radiomics and serum markers. Collecting image data through a multi-modal medical imaging device, and collecting serum marker data through a blood detection device; respectively generating a radiomics feature set and a serum marker time sequence feature set by using a multi-scale feature extraction algorithm and a time sequence analysis model; fusing the features by adopting a dynamic weighted fusion strategy to generate a joint feature matrix; inputting the model into a pre-trained multi-task deep learning model to predict a DCM risk probability; and finally, based on a genetic algorithm, optimizing the diagnosis decision tree and outputting an early DCM diagnosis result. The method is noninvasive and accurate, and can effectively improve the early diagnosis accuracy of DCM.

An AI-driven, cloud-based system (100) for real-time biomedical and pharmaceutical compliance and risk management, including: (a) a compliance knowledge module configured to ingest, interpret and structure regulatory data using natural language processing (NLP) and generate machine-readable compliance rules; (b) a real-time monitoring and event recording module configured to collect and normalise operational data from distributed biomedical and pharmaceutical systems, including laboratory information management systems (LIMS), manufacturing execution systems (MES) and IoT-enabled devices; (c) an intelligent risk assessment and prediction module configured to correlate operational data with compliance rules, calculate dynamic risk scores and predict potential compliance violations using machine learning models; (d) an automated policy and workflow enforcement module configured to initiate remedial actions, assign tasks and log activities based on predefined standard operating procedures (SOPs); (e) an audit readiness and reporting module configured to generate compliance logs, audit trails and standardised regulatory reports in real time; and (f) an adaptive learning and feedback optimization module configured to refine rule sets and predictive models based on feedback, historical data and regulatory updates; g) the modules are integrated into a cloud infrastructure to enable real-time, scalable and predictive compliance and risk management across biomedical and pharmaceutical processes.

A computational evidence platform extracts clinical concepts from medical evidence sources and creates a database of elemental diagnostic factors and elemental investigations links to medical conditions. Input from a person groups factors and investigations makes corrections and adds a ranking. Elemental factors and investigations do not include information specific to their associated conditions but include synonyms and a link to a medical ontology. A patient state is determined by extracting patient known diagnostic factors and investigation results from the patient chart. These known factors and results are matched to the database and a ranking of likely conditions are output. Next-best actions per condition are output by determining factors not yet known and investigations not yet performed. Next-best actions across conditions are determined by performing a recursive tree search of the database and assuming that unknown factors are now known to generate a score for each assumption.

This specification describes systems and methods for performing endoscopy, obtaining medical images for inflammatory bowel disease (IBD) and scoring severity of IBD in patients. The methods and systems are configured for using machine learning to determine measurements of various characteristics related to IBD. The methods and systems may also obtain and incorporate electronic health data of patients along with endoscopic data to use for scoring purposes.

A computational evidence platform extracts clinical concepts from medical evidence sources and creates a database of elemental diagnostic factors and elemental investigations links to medical conditions. Input from a person groups factors and investigations makes corrections and adds a ranking. Elemental factors and investigations do not include information specific to their associated conditions but include synonyms and a link to a medical ontology. A patient state is determined by extracting patient known diagnostic factors and investigation results from the patient chart. These known factors and results are matched to the database and a ranking of likely conditions are output. Next-best actions per condition are output by determining factors not yet known and investigations not yet performed. Next-best actions across conditions are determined by performing a recursive tree search of the database and assuming that unknown factors are now known to generate a score for each assumption.

The invention relates to the technical field of livestock breeding, in particular to a cow manure automatic scoring system and method.The cow manure automatic scoring system comprises an image acquisition unit, a physical property sensor, a chemical component detection module and a data processing unit.The image acquisition unit is used for capturing the form, color and fiber residue of manure; the physical property sensor is used for measuring the water content of excrement and evaluating the viscosity and hardness of the excrement; the chemical component detection module comprises a near infrared spectrum analysis unit and an electrochemical sensor unit; and the data processing unit is used for integrating an AI algorithm, realizing multi-source data fusion and scoring, and uploading the data to the cloud management platform through the communication module. Therefore, the problems that in the prior art, manual scoring is subjective, low in efficiency and difficult to quantify, diseases are difficult to find early due to the lack of rapid component detection means, and accurate nutrition regulation and control are difficult to achieve due to the fact that scoring data are difficult to integrate into a breeding system are solved.

A computational evidence platform extracts clinical concepts from medical evidence sources and creates a database of elemental diagnostic factors and elemental investigations links to medical conditions. Input from a person groups factors and investigations makes corrections and adds a ranking. Elemental factors and investigations do not include information specific to their associated conditions but include synonyms and a link to a medical ontology. A patient state is determined by extracting patient known diagnostic factors and investigation results from the patient chart. These known factors and results are matched to the database and a ranking of likely conditions are output. Next-best actions per condition are output by determining factors not yet known and investigations not yet performed. Next-best actions across conditions are determined by performing a recursive tree search of the database and assuming that unknown factors are now known to generate a score for each assumption.

The invention provides a multi-modal large language model for generating a hepatocellular carcinoma key pathological diagnosis report, a framework main body is a visual coding module, and a multi-modal feature alignment module, a multi-head low-rank attention mechanism, an enhanced medical MoE mechanism and a structured output decoding layer are also introduced. The visual coding module is constructed on the basis of a Swin Transform architecture, visual pre-training is completed on hepatocellular carcinoma MRI data, and after a task specific classification head is stripped, a trunk feature extraction network is reserved to serve as an image modal representation encoder. The multi-modal feature alignment module guides the model to learn a cross-modal semantic mapping relation between a hepatocellular carcinoma MRI image and a key pathological diagnosis report language, image modal input is a visual feature sequence, and text modal output is a structured description text; and the structured output decoding layer generates six types of liver cancer focus attributes. According to the method, the pre-operative multi-parameter and multi-stage enhanced MRI image is utilized, and the open-source large model is finely adjusted to generate a matched liver cancer postoperative pathology report.

Described herein are methods such as multi-omic methods for assessing a disease such as cancer. The multi-omic methods may integrate proteomic, transcriptomic, genomic, lipidomic, or metabolomic data. The method screening diseases or disease states. Also described herein are methods for screening for diseases or disease states from biological samples. The methods may include assessing whether a nodule, mass, or cyst is cancerous.

Systems and methods for automatically populating a post-operative report of a surgical procedure are disclosed. A system may include at least one processor configured to implement a method including receiving an identifier of a patient, an identifier of a healthcare provider, and surgical footage of a surgical procedure performed on the patient. The method may include analyzing frames of the surgical footage to identify phases of the surgical procedure based on interactions between medical instruments and biological structures and, based on the interactions, associate a name with each phase. The method may include determining a beginning of each phase and associating a time marker with the beginning of each phase. The method may include populating a post-operative report with the patient identifier, the names of the phases, and time markers associated with the phases in a manner that enables the health care provider to alter the post-operative report.

The invention provides a medical examination data analysis system and method based on artificial intelligence. The method comprises the steps of obtaining a time sequence data matrix of multiple examination indexes of a target patient at different time nodes through medical examination data of the target patient; labeling pathological labels of various examination indexes in the medical examination data, and determining medical semantic association features among different examination indexes of the target patient through the pathological labels; according to the medical semantic association features and the time sequence data matrix, determining a time sequence association relationship of different inspection indexes of the target patient on a pathological level, and generating a fusion feature vector of the health state of the target patient according to the time sequence association relationship; and an abnormal evolution feature of the current health state of the target patient is obtained by combining an abnormal detection model with the fusion feature vector, and then an auxiliary analysis result of the pathological risk of the target patient is output to medical personnel. By adopting the scheme of the invention, the dynamic change trend analysis of the disease course risk state of the patient can be realized based on the medical semantic perception ability.

The invention relates to a motion evaluation method, device and equipment based on multi-modal physiological data and a medium, and the method comprises the steps: solving the problem of space-time mismatch of the multi-modal data through sampling timestamps of a hardware clock protocol for multi-source physiological signals such as a makeup rate, myoelectricity, blood lactic acid and the like; equipment interference and motion artifacts are eliminated, and the signal quality is improved; dynamic characteristics such as heart rate variability, myoelectricity root mean square and blood lactic acid gradient in the sliding window are calculated; dividing exercise intensity intervals based on the individually calibrated heart rate percentage and the myoelectricity activation degree threshold, and detecting conversion candidate points; and recognizing a motion intensity critical state in real time through a self-adaptive threshold model driven by historical data, and generating a comprehensive evaluation result containing a thermodynamic diagram and an early warning report. According to the method, the limitation of a traditional fixed threshold model is broken through, multi-modal data deep fusion and individual dynamic adaptation are achieved, the exercise intensity critical point detection precision is improved, and real-time decision support is provided for training load optimization and rehabilitation progress evaluation.

The invention discloses a multi-department medical sample collaborative management system and method, and relates to the technical field of medical information, and the system comprises an integrated information interaction platform which is used for achieving the real-time sharing of basic information, clinical diagnosis information and inspection reports of patients; the unique identification module is used for carrying out full-life-cycle tracking on a patient sample through a bar code or a radio frequency tag and dynamically associating the patient sample with patient information; the Internet of Things monitoring module is used for collecting and uploading temperature and humidity parameters of the sample storage environment in real time and triggering abnormal early warning; the automatic storage equipment executes sample classified storage and calling based on a platform instruction, and synchronously updates a sample state with the information system; and the data security module is used for realizing data encryption, dynamic authority management and operation traceability by adopting role-based access control and a block chain technology. According to the technical scheme, the core problems of data islands, low operation efficiency, weak safety and the like in traditional medical management can be systematically solved.

Provided herein are methods and systems for diagnosing pathological conditions using machine learning and artificial intelligence models. An exemplary method can include loading an abundance matrix that represents mass spectrometry reads of a sample of a plurality of volatile organic compounds (VOCs) extracted from a biological sample. The abundance matrix can represent each of the plurality of VOCs in a mass-to-charge ratio dimension, an abundance dimension, and a retention time dimension. The method can include providing the abundance matrix to a machine-learning model. The machine- learning model can be trained on abundance matrixes of biomarkers of VOCs collected from healthy and diseased subjects. The method can include receiving, from the machine-learning model, a prediction of a state of a disease state.

The invention discloses a prognosis evaluation method and system for II-III stage colorectal cancer patients, and relates to the technical field of wisdom medicines.The prognosis evaluation method comprises the steps that variables related to survival prognosis of the patients are screened, potential variables influencing RFS and OS of the patients are obtained, and prognosis outcomes of the colorectal cancer patients are evaluated by evaluating relevance between various indexes and prognosis outcomes of the colorectal cancer patients and correcting confounding factors; screening out indexes having important value for the model; the screened indexes and machine learning algorithms are utilized to construct RFS and OS prognosis models of the CRC patients, the RFS and OS prognosis models are used for performing prognosis evaluation on the CRC patients in the II-III stages, and the machine learning algorithms comprise six types of LR, RF, XGB, SVC, MLP and GNB. By integrating clinical data and a machine learning technology, an efficient and accurate tool is provided for prognosis evaluation of the II-III stage colorectal cancer patient, and a scientific basis is provided for making clinical decision support and an individualized treatment scheme.

The invention relates to the technical field of biomedical detection, and discloses a non-invasive sperm cell death and viability detection method, which utilizes a bright field image and a fluorescence image to train a fluorescence-assisted bright field attention network, introduces a fluorescence attention guidance module to provide guidance for training of a Transformer encoder, and realizes non-invasive sperm cell death and viability detection through priori knowledge of the fluorescence image. By means of the method, the model can be quickly focused on key features displayed in the fluorescent highlight area, the situation that training resources are consumed on a large amount of irrelevant information is avoided, convergence is accelerated, the model training time is shortened, meanwhile, the detection precision is improved, and then a more accurate and efficient sperm cell death and activity detection model is obtained. And during actual detection, the sperm cell death and viability detection can be realized only by collecting a microscopic image, pre-processing the microscopic image and inputting the preprocessed microscopic image into the model without dyeing a sperm sample, so that the damage of a traditional detection method to sperms is avoided, the non-invasive detection of the sperm cell death and viability is realized, and the method is more suitable for clinical detection.

A computer implemented method, a computing device, a laboratory instrument, a computer program product and a computer readable storage medium for selectively de-identifying protected health information (PHI) are provided. The method comprises accessing a first data file, the first data file comprising at least a first data item, wherein the first data item comprises PHI and first PHI category information, wherein the first PHI category information is indicative of a first PHI category of a plurality of PHI categories, the PHI in the first data item belonging to the first PHI category. The method further comprises accessing the first PHI category information. The method further comprises assessing, based on the first PHI category information, whether the PHI in the first data item is to be de-identified or not. If the PHI in the first data item is to be de-identified, the method further comprises generating a second data item by modifying the first data item such that the protected health information is de-identified.

The invention provides an intelligent medical information system based on multi-system integration, a data security management method and device, electronic equipment and a storage medium, and is applied to the technical field of medical data processing. According to the method, three types of information including core security elements, multi-system heterogeneous adaptation (including HIS / LIS / EMR interface specifications and the like) and full-process auditing (including operation logs and the like) are obtained. Normalizing the core security elements by using technologies such as AI multi-mode privacy identification and the like to generate a standardized security baseline file; heterogeneous adaptation information is processed through a lightweight API connector and the like, and a multi-system security access scheme is formed. Associating the baseline file with the access scheme, and generating a full-life-cycle protection strategy in a zero-trust architecture; and processing the audit information to generate a dynamic security audit report. And finally, based on a security-adaptation linkage decision engine and compliance verification, outputting a cross-system data security sharing scheme and a privacy disclosure emergency response instruction, and realizing a medical data security management closed loop.

The invention discloses an internet-of-things senile disease nursing system supporting equipment state monitoring, and relates to the technical field of internet-of-things senile nursing. An acquisition module realizes multi-index monitoring by using a flexible sensor and a non-invasive technology; the edge computing unit fuses the neuromorphic architecture and federal learning; the equipment monitoring module predicts faults in combination with acoustic emission and thermal imaging technologies; the health assessment engine carries out disease early warning through causal reasoning and a knowledge graph; the early warning system realizes hierarchical response and multi-terminal linkage; and the block chain platform ensures data security and sharing. Through multi-module collaborative innovation, precise collection of elderly health data and real-time monitoring of equipment states are realized, diseases and equipment faults are early warned in advance, an intelligent evaluation engine can predict complications, multi-modal early warning improves response efficiency, a block chain technology guarantees data security, medical resource sharing is supported, and the system is suitable for popularization and application. And the safety, timeliness and intelligent degree of senile disease nursing are comprehensively improved.

A platform for characterizing biomolecules, biological tissue sections, viruses, or other particles of interest in a non-invasive, high-throughput, cost-effective, and label-free manner. The platform includes a merged set of imaging modalities including and capable of interferometric microscopy and wide-field or confocal microscopy (such as, for example, a wide-field super-resolution surface enhanced Raman spectroscopy, SERS), although some aspects may be employed with data sets only received from wide-field or confocal microscopy. Related devices, systems, methods, techniques, and variations to the same are also provided.

A method for providing on demand verifiability of a medical metric for a patient using a distributed ledger is disclosed. The method may include receiving, by a node that is part of a network of nodes with access to the distributed ledger, a request to verify the medical metric of the patient, wherein the request comprises an identification of the patient. The method may include querying, using the identification of the patient, the distributed ledger to determine the medical metric of the patient, wherein the distributed ledger comprises at least one block including medical information pertaining to the patient, and the medical information is endorsed by a medical personnel associated with causing the medical information to be stored in the block. The method may include providing the medical metric to the computing device to cause a computing device to perform a responsive action based on the medical metric.

The invention discloses a blood, urine and body fluid collecting, detecting, analyzing and uploading system based on multi-sensor integration, which comprises the following modules: a blood collecting module for collecting a blood sample; the urine collection module is used for detecting urine; the body fluid collecting module is used for detecting body fluid; the data processing module is used for preprocessing data; the feature extraction and classification module is used for constructing a multi-modal feature matrix based on a neural structure search network, a support vector machine and a random forest algorithm; the anomaly detection module is used for generating a weighted anomaly score in combination with an isolated forest and a depth anomaly detection model; the time sequence analysis module is used for analyzing the health trend by using a variational auto-encoder-generative adversarial network; the health portrait and risk assessment module is used for constructing a health map by adopting a graph convolutional network; and the encryption and uploading management module is used for encrypting by using AES and RSA and managing the data access authority based on the intelligent contract. According to the invention, a multi-modal sensor and an intelligent algorithm are integrated, and collection, detection, analysis, encryption and uploading of blood, urine and body fluid are realized.