35 results about "Physiological condition" patented technology

Medical devices and related systems and methods are provided. A method of controlling medication delivery based on sensor input involves obtaining a measurement parameter representing an electrical response of a first instance of a sensing element to a physiological condition of a person. The measurement parameter is converted into a calibrated measurement parameter using calibration data specific to the first instance of the sensing element. The method further involves determining a measurement value using the calibrated measurement parameter as input to a performance model. The performance model is derived from historical calibrated measurement parameters and corresponding reference values. The historical calibrated measurement parameters are from other instances of the sensing element. A command is then determined based on the measurement value and sent to a medical device. The command causes the medical device to deliver a dose of medication influencing the physiological condition of the person.

A system including: an antenna configured to be implanted in a region a living body, wherein a frequency response and / or attenuation response of the antenna shifts in response to changes in a physiological condition of the living body at the region; an input / output module outside the living body and configured to actuate the antenna to generate a response signal and to receive the response signal, wherein the response signal indicates a frequency response and / or attenuation response of the antenna; and a processor configured to: detect whether the frequency response and / or attenuation response indicates a shift in the frequency and / or attenuation response of the antenna; and in response to the detection of the shift issue and / or record a notice that a change occurred in the physiological condition at the region inside the living body.

Medical devices and related systems and methods are provided. A method of controlling medication delivery based on sensor input involves obtaining a measurement parameter representing an electrical response of a first instance of a sensing element to a physiological condition of a person. The measurement parameter is converted into a calibrated measurement parameter using calibration data specific to the first instance of the sensing element. The method further involves determining a measurement value using the calibrated measurement parameter as input to a performance model. The performance model is derived from historical calibrated measurement parameters and corresponding reference values. The historical calibrated measurement parameters are from other instances of the sensing element. A command is then determined based on the measurement value and sent to a medical device. The command causes the medical device to deliver a dose of medication influencing the physiological condition of the person.

Techniques for physiological measurement initiation using multiple sensors are described. In one or more implementations, first physiological data are collected from a first sensor that measures a first physiological feature of an individual. The first physiological data are analyzed in real-time to detect a physiological condition of the individual. A second sensor is activated, responsive to detection of the physiological condition, to begin collecting second physiological data measuring a second physiological feature of the individual.

In one embodiment, a method comprising: (a) receiving a set of physiological data associated with at least one health condition of an animal subject; (b) receiving a set of environmental data associated with one or more environment conditions to which the subject is or has been exposed; (c) determining a set of operating parameters for at least one environmental device based at least partially on at least a portion of the set of physiological data and at least a portion of the set of environmental data; and (d) transmitting the set of operating parameters to the at least one environmental device to at least partially control at least one controlled environmental condition to which the subject is exposed to thereby at partially control the at least one health condition.

The invention relates to a system for determining cellular respiration and nutrient metabolism of living cells or tissues, the system comprising: a cell container configured to receive and maintain a biological sample; a gas volume in fluid communication with the cell container, the gas volume containing gaseous components produced by metabolic activity of the biological sample; an optical detection unit configured to detect a target gas species in the gas volume by wavelength-selective absorption spectroscopy, the optical detection unit being further configured to distinguish between different isotopic species of the target gas species, the optical detection unit comprising an illumination source and detector arrangement optically coupled to the optical detection unit and configured for measurement of absorption signals corresponding to different isotopes of the target gas species; and an electronic control and evaluation unit operatively connected to the optical detection unit, the electronic control and evaluation unit being configured to acquire and process absorption data, determine absolute values and / or temporal variations of the target gas species concentration and isotopic composition, and output respiration-related parameters of the biological sample. In this way, a system is provided that enables precise and efficient determination of carbon dioxide produced by living cells or tissues under physiological conditions.

The subject matter of the present disclosure generally relates to techniques for applying focused ultrasound energy to a region of interest in a subject to induce neuromodulation of the celiac plexus for treating inflammatory bowel disease. The region of interest may include at least a portion of the peripheral ganglia of the celiac plexus.

The invention discloses an AQP4-IgG (immunoglobulin G) detection method based on the combination of AQP4-M1 and M23 subtypes. According to the invention, two protein subtypes of AQP4-M1 and M23 are mixed in proportion by simulating physiological conditions and co-transfected to 293T cells, so that heterotetramers are formed and further assembled into a complete orthogonal array (OAP), and more antigen epitopes are exposed, thereby remarkably improving the recognition specificity and detection sensitivity of the AQP4-IgG antibody. Compared with traditional single subtype detection, the system can more truly simulate abundance and distribution of the AQP4 subtype in vivo, reduces false positive and false negative risks, and has a great value of rapidly and accurately screening AQP4-IgG related diseases clinically.

The present disclosure relates to a concept for providing a score indicative of a physiological condition of at least one individual. The concept include measuring physiological or behavioral data of the individual, determining contextual data comprising a measurement context and / or socio-demographic features associated with the individual determining a metric based on the measured physiological or behavioral data, and determining the score by comparing the metric against a predicted value from a prediction model trained with the contextual data.

Rapid and accurate detection of molecular species with a high degree of selectivity and sensitivity constitutes the ultimate goal of designing sensors for various applications, from studying nutrients in soil-water systems to assessing physiological conditions in human health. For the first time, MXene systems, such as atomically thin two-dimensional Ti3C2Tx layered materials, can be used for electrochemical detection of phosphates, one of the key molecules for sustainability of life on earth, and one of the major contributors to environmental pollution. The MXene sensors are highly selective towards phosphates.

A system and method are provided to provide users with guidance on managing physiological conditions such as diabetes. [Solution] The decision can be based on the patient's glucose concentration level. The glucose concentration level can be provided to a stored model to determine the state. Guidance can be determined at least partially based on the determined state.

The present disclosure generally relates to a system and a computerized method (200) for monitoring a physiological condition of a user with a photoplethysmography (PPG) signal (310). The method (200) includes: receiving (210) a set of PPG signals (310), each PPG signal measured from a different body part of a user; identifying a plurality of pulse wavelets (312) in each PPG signal (310); aligning the corresponding two-dimensional pulse wavelets (312) in three dimensions; and constructing a set of three-dimensional morphological representations (400) from the aligned pulse wavelets (312), where a set of physiological parameters of the user may be measured from the constructed three-dimensional morphological representations (400) (410).

The present invention relates to the compositions, methods, and associated devices (1) for the cryopreservation of biological specimens that enables to freeze and thaw the entire specimen by straightforwardly protecting its three-dimensional architecture. The invention comprises compositions including reagents to protect the specimen and preserve the physiological conditions. The methods comprise fewer steps excluding the need for other solutions used in conventional methods. The methods also eliminate stressful steps for biological specimens in conventional methods including harvesting, pipetting, centrifuging, and transferring. With this invention, the entire content of the specimen can be frozen, stored long-term in a single cell culture vessel with one of the associated devices (1) described here, and then thawed while still in the device (1). The biological specimens frozen by that method render high post-thawing viability. Moreover, the invention reduces cryoprotectant-related toxic events, human errors, and contamination risk.

Disclosed herein are systems, devices, and methods for measuring sensor data of a user seated on a toilet and using statistical models and / or machine learning to detect / identify the user based on the measured sensor data. In some embodiments, the systems described herein can include multiple sensors, including force sensors, ECG sensors, PPG sensors, and other sensors, located within and / or integrated into the toilet. The sensors can measure and / or record sensor data, including load and force, BCG data, ECG data, PPG data, bioimpedance, etc., and can determine one or more physiological parameters and / or characteristics about the user based on the sensor data. The system can further be configured to associate the measured sensor data and biological conditions and / or characteristics with a user identifier, such that the user can be identified by comparing the user identifier with sensor data measured while the subject (e.g., an unknown subject) is seated on the toilet.

Systems and methods for multimodal monitoring of physiological conditions are disclosed. The systems include a sensor hub that can detect a presence of sensor devices in its environment. The sensor devices are configured to sense a parameter relevant to patient fluid inflow or outflow. The sensor hub associates at least a subset of the detected sensor devices with a patient profile and determines parameters relevant to patient fluid inflow or outflow that the associated sensor devices are capable of sensing. Based on the determined parameters, the sensor hub enters a mode of multimodal monitoring, activates sensor streams from the associated sensor devices in accordance with the mode of multimodal monitoring, establishes a secured communication channel with a patient medical record system, and transmits an update to the patient medical record system based on data received from the sensor streams.

The present disclosure is related to a method for improving physiological state by light stimulation in which light of a specific wavelength such as violet light is irradiated at a specific blinking frequency, and an apparatus used for the same. More specifically, improvement of physiological state such as, improvement or suppression of dermatitis, improvement or suppression of alopecia, improvement of hair condition, improvement or suppression of graying of hair, improvement or suppression of hearing loss, improvement or suppression of vision loss, improvement or enhancement of muscle strength, improvement or suppression of kyphosis, improvement or suppression of pain and / or feeling of discomfort, improvement of autonomic nerve abnormalities, improvement of healthy life expectancy, and obesity control is carried out by irradiating light of a specific wavelength such as violet light to a living body.

The present disclosure relates to immunoassays for NF-L performed on liquid samples derived from physiological fluids such as venous blood to detect the presence or absence of a physiological condition by quantifying one or a combination of NF-L determinations at concentrations indicative of the condition.

The patient monitoring device includes an ECG sensor coupled to the patient, a sensor coupled to the patient and configured to generate a bio-oscillation signal, and a radio frequency monitoring device configured to generate information corresponding to electromagnetic energy reflected from the patient's thoracic cavity. The processor processes the ECG signal, the bio-oscillation signal, and the radio frequency information to generate a plurality of physiological parameters of the patient. The processor further performs at least one of a predictive analysis and a trend analysis of the plurality of physiological parameters to determine a current clinical condition of the patient. The trend analysis includes determining a substantial relationship between changes in the plurality of physiological parameters. The processor may further compare the patient's current clinical condition with predetermined clinically actionable criteria to determine one or more clinically actionable events and provide an output related to the one or more clinically actionable events.

According to the physiological feature signal processing method and system based on the fourth-order kinetic model, the fourth-order kinetic model is constructed for the collected physiological signals of the target individual based on the fourth-order three-point boundary value problem, various boundary conditions can be synchronously met, it is guaranteed that model output conforms to the physiology principle from the mathematical level, and the physiological feature signal processing accuracy is improved. Results which do not conform to actual physiological conditions are avoided; by establishing the mapping relation between the patient physiological turning time and the model boundary point parameters, modeling is performed for the unique physiological rhythm of each target individual, the integrating degree of the fourth-order kinetic model and the actual physiological state of the target individual is improved, and a more accurate basis is provided for personalized medical diagnosis; the physiological consistency of multi-modal signal output is ensured in combination with cone constraint, and accurate synchronization of different modal signals in a time domain is realized.

The application discloses a method for detecting biomembrane and biomolecule interaction based on terahertz technology, which comprises the following steps: step 1, preparing a sample containing target biomembrane and target biomolecule; step 2, providing a terahertz spectrum device, wherein a container for containing the sample in step 1 to perform terahertz detection is arranged on the device; and step 3, adding the sample in step 1 into the container in step 2 to perform terahertz spectrum detection, and obtaining optical properties of terahertz frequency of biomembrane and biomolecule interaction. The application provides a method for sensitively detecting biomembrane and biomolecule interaction under near physiological conditions, and the multi-scale motion information carried by the terahertz spectrum can realize detailed characterization of biomembrane and biomolecule interaction at a dynamic level.

Techniques for physiological measurement initiation using multiple sensors are described. In one or more implementations, first physiological data are collected from a first sensor that measures a first physiological feature of an individual. The first physiological data are analyzed in real-time to detect a physiological condition of the individual. A second sensor is activated, responsive to detection of the physiological condition, to begin collecting second physiological data measuring a second physiological feature of the individual.

The detailed implementations described herein disclose a method of predicting oxygen desaturation, the method comprising: generating an input sequence of oxygen levels based on a sequence of input signals, the input signals being indicative of a physiological condition of a patient; generating an input feature sequence based on at least one of the sequence of input signals and the input sequence of oxygen levels; generating, using a neural network, a sequence of predicted values of the oxygen levels based on the input feature sequence; comparing the sequence of predicted values of the oxygen levels with the input sequence of oxygen levels over a predetermined time window to generate a sequence confidence value of the prediction; and generating an oxygen desaturation prediction based on the sequence of predicted values in response to determining that the sequence confidence value of the prediction is higher than a threshold confidence value.

This disclosure is about a method for moderating physiological bodily conditions of a subject comprising administering an appropriate amount of appropriate wave for an appropriate duration to the said subject thereby modulating the physiological conditions of the said subject. A device for moderating function in a subject capable of generating or transmitting appropriate life wave to moderate said function in said subject is also disclosed. The duration and intensity of the waves can be adjusted depending on different physiological conditions. A method for moderating functions in a subject using life waves comprising steps of selecting a wave of appropriate wavelength; selecting an appropriate amplitude; and choosing optimal duration so that the chosen life wave can affect and then moderate the said function is also disclosed.

The utility model provides a cell culture device for biological research and development, which relates to the technical field of auxiliary devices for biological experiments and comprises a main body, a culture bin is arranged in the main body and used for placing a culture dish for culturing cells, and an upper cover for sealing the culture bin is arranged at the top of the main body. According to the device, through the pneumatic control assembly, the pressure and composition of gas in the culture bin can be accurately adjusted, cell growth environments under different physiological conditions are simulated, and the survival rate and growth efficiency of cells are improved. The design of one-way air holes ensures one-way flowing of air, unnecessary air exchange is avoided, controllability of the system is enhanced, external pollution risks are reduced, the temperature control assembly enables temperature distribution in the culture bin to be more uniform, local overheating or supercooling is avoided, and it is ensured that cells grow in a stable temperature environment. The electric heating tubes are distributed at equal intervals, temperature changes can be responded rapidly, it is guaranteed that the temperature reaches and maintains a set value rapidly, and the requirement for rapid temperature adjustment or constant-temperature experiments is met.

The application discloses a method for researching a whole surface mechanical atlas of a single adherent biological cell under physiological conditions, and belongs to the technical field of microscopic imaging testing. The method is based on the principle of nanoindentation technology under physiological conditions, and uses an optical microscope to perform coarse positioning on a sample to be tested, and selects the sample and sets a grid standard according to requirements. Each square of the grid is used as a basic unit, and mechanical property testing is performed on the position of each center point, and finally the testing results are output in the form of a grid pixel, so that the whole surface mechanical atlas of the adherent cell is obtained. The purpose of the application is to obtain the mechanical information of the whole cell surface under physiological conditions by using microscopic manipulation technology, and to output the analysis results in the mode of a pixel map, so that people can more intuitively understand the adhesion force difference of the whole cell surface, and a method for testing results is provided, which is more intuitive, simple and comprehensive for the in-depth research on the physical properties of cells.

The application provides a capacitive sensor for monitoring the physiological condition of a carrier plant, comprising: at least one liquid metal segment, which is in a liquid state at room temperature, and which is filled in the inner cavity of the carrier plant; when the liquid metal segment is one, at least one liquid metal layer is further included, which is arranged on the outer wall of the inner cavity of the carrier plant, and when a plurality of liquid metal layers are included, the adjacent liquid metal layers are arranged on the outer wall of the inner cavity of the carrier plant in a spaced manner; when the liquid metal segments are a plurality, the liquid metal segments are respectively filled in the adjacent inner cavities of the carrier plant. The liquid metal can adapt to the growth of the plant and change the shape, and can accurately monitor the growth signal inside the plant, thereby achieving the technical purpose of monitoring the growth condition of the plant in real time. The application further provides a manufacturing method of the capacitive sensor for monitoring the physiological condition of the carrier plant.