1232 results about "Physiological condition" patented technology

The present invention includes a handheld device and a main device, wherein the handheld device is held by an athlete and the main device is moved with the athlete. Through a measuring device acquiring a physiological condition of the athlete and a movement state of the handheld device and transmitting thereof to the main device, the main device can produce an exercise indication signal according thereto, so that the athlete can obtain an exercise direction and also can manage the physical condition during exercise.

Apparatuses and methods for medical monitoring physiological characteristic values such as blood glucose levels for the treatment of diabetes, are presented. The apparatuses and methods provide advanced alarm and reminder functions, as well as advanced data presentation tools to further facilitate convenient and efficient management of various physiological conditions. For example, an alarm repeat delay can be used to prevent redundant alarms for a specified period and an alarm snooze function can be used to prevent alarms generally for a specified period.

A method of communicating with a physiological sensor is disclosed. In an embodiment, the method includes supplying power through a first conductor in a first mode to the physiological sensor and communicating with an information element through the first conductor in a second mode. The physiological sensor includes the information element, a power supply configured to receive and store power from the first conductor in the first mode, and sensing circuitry configured to receive power from the first conductor in the first mode. The power supply releases the stored power to the sensing circuitry in the second mode.

A signal processor which acquires a first signal, including a first primary signal portion and a first secondary signal portion, and a second signal, including a second primary signal portion and a second secondary signal portion, wherein the first and second primary signal portions are correlated. The signals may be acquired by propagating energy through a medium and measuring an attenuated signal after transmission or reflection. Alternatively, the signals may be acquired by measuring energy generated by the medium. A processor of the present invention generates a primary or secondary reference signal which is a combination, respectively, of only the primary or secondary signal portions. The secondary reference signal is then used to remove the secondary portion of each of the first and second measured signals via a correlation canceler, such as an adaptive noise canceler, preferably of the joint process estimator type. The primary reference signal is used to remove the primary portion of each of the first and second measured signals via a correlation canceler. The processor of the present invention may be employed in conjunction with a correlation canceler in physiological monitors wherein the known properties of energy attenuation through a medium are used to determine physiological characteristics of the medium. Many physiological conditions, such as the pulse, or blood pressure of a patient or the concentration of a constituent in a medium, can be determined from the primary or secondary portions of the signal after other signal portion is removed.

A medical characterization system is configured to input medical-related continuous parameters and discrete data so as to calculate a characterization timeline indicative of a physiological condition of a living being. A data source is in sensor communications with a patient so as to generate a continuous parameter. The data source also provides test data responsive to the patient at a test time. The test data is available to a characterization processor at a result time. The characterization processor is also responsive to the continuous parameter so as to generate a medical characterization as a function of time. A characterization analyzer enables the characterization processor to update the medical characterization in view of the test data as of the test time.

Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and / or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties. Methods and systems for localizing physiological condition(s) and / or biological response(s), such as pain, by targeting and selectively probing tissues using the application of focused ultrasound are also provided.

A method of context-based communication of physiological information over a network includes receiving physiological information, preparing a contextual data package, establishing a network connection, and communicating the contextual data package. The physiological information is received with a portable network interface module from at least one physiological monitor coupled to a single medical patient. The physiological information is related to a physiological condition of the medical patient, and the portable network interface module is exclusively assigned to the medical patient. The contextual data package is prepared with the portable network interface module. The contextual data package includes context information related to the medical patient and the physiological information. The network connection is established with a user over a network with the portable network interface module, and the portable network interface module manages the network connection with the user. The contextual data package is communicated to the user over the network with the network connection.

Sealable and repositionable implant devices are provided with features that increase the ability of implants such as endovascular grafts and valves to be precisely deployed or re-deployed, with better in situ accommodation to the local anatomy of the targeted recipient anatomic site, and / or with the ability for post-deployment adjustment to accommodate anatomic changes that might compromise the efficacy of the implant. A surgical implant includes an implant body and a selectively adjustable assembly attached to the implant body, the assembly having adjustable elements and being operable to cause a configuration change in a portion of the implant body and, thereby, permit implantation of the implant body within an anatomic orifice to effect a seal therein under normal physiological conditions.

Apparatuses and methods for medical monitoring physiological characteristics values such as blood glucose levels for the treatment of diabetes, are presented. The apparatuses and methods provide dynamic glucose monitoring functions that perform predictive analysis to anticipate harmful conditions, such as glucose crash and hyperglycemic incidents for a patient. The dynamic functions can also be used to maximize athletic performance and warn of inadequate nocturnal basal rate. Other aspects include advanced alarm and reminder functions, as well as advanced data presentation tools to further facilitate convenient and efficient management of various physiological conditions.

Apparatuses and methods for medical monitoring physiological characteristics values such as blood glucose levels for the treatment of diabetes, are presented. The apparatuses and methods provide dynamic glucose monitoring functions that perform predictive analysis to anticipate harmful conditions, such as glucose crash and hyperglycemic incidents for a patient. The dynamic functions can also be used to maximize athletic performance and warn of inadequate nocturnal basal rate. Other aspects include advanced alarm and reminder functions, as well as advanced data presentation tools to further facilitate convenient and efficient management of various physiological conditions.

The presence or absence of objects tagged with transponders may be determined in an environment in which medical procedures are performed via an interrogation and detection system which includes a controller and a plurality of antennas positioned along a patient support structure. The antennas may be positioned along an operating table, bed, mattress or pad, sheet, or may be positioned on a drape, or shade. Respective antennas may successively be activated to transmit interrogation signals. Multiple antennas may be monitored for responses from transponders to the interrogation signals. For example, all antennas other than the antenna that transmitted the most recent interrogation signal may be monitored. Antennas may be responsive to force, a signal indicative of such force being produced. A wireless physiological condition monitor may detect patient physiological conditions and wirelessly transmit signals indicative of such.

The present invention provides systems and methods for monitoring in real time the physiological status of one or more subjects, especially subject engaged in potentially hazardous or dangerous activities. Systems include wearable items with one or more physiological sensors and a local data unit (LDU) operatively coupled to the sensors. The LDUs digitize and filter sensor data, extract physiological parameters, determine abnormal or not acceptable physiological conditions, and communicate to external monitoring facilities. The external facilities display status and data concerning monitored subjects. In preferred embodiments, communication between the LDUs and the external monitoring facilities dynamically adjusts to the condition of the subjects and to system changes such as subjects and external facilities entering and leaving and / or moving from place to place. The invention also provides program products for performing this invention's methods.

Apparatus and methods for attenuating environmental interference are described. A wearable monitoring apparatus includes a housing configured to be attached to the body of a subject and a sensor module that includes an energy emitter that directs energy at a target region of the subject, a detector that detects an energy response signal—or physiological condition—from the subject, a filter that removes time-varying environmental interference from the energy response signal, and at least one processor that controls operations of the energy emitter, detector, and filter.

Apparatuses and methods for medical monitoring physiological characteristic values such as blood glucose levels for the treatment of diabetes, are presented. The apparatuses and methods provide advanced alarm and reminder functions, as well as advanced data presentation tools to further facilitate convenient and efficient management of various physiological conditions. For example, an alarm repeat delay can be used to prevent redundant alarms for a specified period and an alarm snooze function can be used to prevent alarms generally for a specified period.

An intelligent medical vigilance system that observes and analyzes, and, only in the event of a clinically significant negative condition, notifies and reports the event to the care staff utilizing the hospital's existing nurse call system. The device includes a bedside unit connected to a pad or coverlet with a sensor array (placed under the patient) and also to an existing hospital nurse call system via an interface. Within the physical bedside unit are a signal processor and an alarm processor that measure data and evaluate whether a clinically significant event is occurring. The bedside unit is a wall-mounted unit with a display that becomes active when an alarm condition is enabled. The sensing pad or coverlet is a thin, piezoelectric film, or other similar sensing technology, with an array of sensors sheathed in soft padding and is not directly in contact with the skin of the patient. The nurse call feature is made up of hardware, software and cabling to connect to the nurse call system already installed in the hospital or care facility. The monitoring system can also be installed in vehicles to monitor operator physiological conditions.

A medical characterization system is configured to input medical-related continuous parameters and discrete data so as to calculate a characterization timeline indicative of a physiological condition of a living being. A data source is in sensor communications with a patient so as to generate a continuous parameter. The data source also provides test data responsive to the patient at a test time. The test data is available to a characterization processor at a result time. The characterization processor is also responsive to the continuous parameter so as to generate a medical characterization as a function of time. A characterization analyzer enables the characterization processor to update the medical characterization in view of the test data as of the test time.

Sensors and monitors for a physiological monitoring system having capability to indicate an accuracy of an estimated physiological condition. The sensor senses at least one physiological characteristic of a patient and is connectable to a monitor that estimates the physiological condition from signals detected by the sensor. The sensor includes a detector for detecting the signals from the patient which are indicative of the physiological characteristic. The sensor is associated with a memory configured to store data that defines at least one sensor signal specification boundary for the detected signals. The boundary is indicative of a quality of the signals and an accuracy of the physiological characteristic estimated from the signals by the monitor. The sensor further includes means for providing access to the memory to allow transmission of the data that defines the at least one sensor boundary to the monitor.

The present invention is directed to universal T cells and their use in treating diseases and other physiological conditions. More specifically, the present invention is directed to universal T cells and their use in treating treating B-lineage acute lymphoblastic leukemia (B-ALL) in particular and malignancy in general. The universal T cells contain (i) nucleic acid encoding a chimeric antigen receptor (CAR) to redirect their antigen specificity and effector function and (ii) nucleic acids encoding shRNA and / or siRNA molecules to down-regulate cell-surface expression of T cell classical HLA class I and / or II genes to avoid recognition by recipient T cells. The universal T cells may also contain a nucleic acid encoding a non-classical HLA gene, such as an HLA E gene to enforce expression of HLA E genes and / or an HLA G gene to enforce expression of HLA G genes, to avoid recognition by recipient NK cells. The universal T cells may further contain a nucleic acid encoding a selection-suicide gene.

A system and method are disclosed for identifying monitoring and evaluating hazardous or potentially hazardous conditions. The system may be worn by safety personnel to detect equipment conditions such as low power supply, environmental conditions such as ambient temperature and / or physiological conditions such as heart rate of a wearer. The system further includes a control unit having electronics operable to communicate signals associated with equipment, environmental and physiological conditions.

Reversible pegylated drugs are provided by derivatization of free functional groups of the drug selected from amino, hydroxyl, mercapto, phosphate and / or carboxyl with groups sensitive to mild basic conditions such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS), to which group a PEG moiety is attached. In these pegylated drugs, the PEG moiety and the drug residue are not linked directly to each other, but rather both residues are linked to different positions of the scaffold Fmoc or FMS structure that is highly sensitive to bases and is removable under physiological conditions. The drugs are preferably drugs containing an amino group, most preferably peptides and proteins of low or medium molecular weight. Similar molecules are provided wherein a protein carrier or another polymer carrier replaces the PEG moiety.

Reversible pegylated drugs are provided by derivatization of free functional groups of the drug selected from amino, hydroxyl, mercapto, phosphate and / or carboxyl with groups sensitive to mild basic conditions such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS), to which group a PEG moiety is attached. In these pegylated drugs, the PEG moiety and the drug residue are not linked directly to each other, but rather both residues are linked to different positions of the scaffold Fmoc or FMS structure that is highly sensitive to bases and is removable under physiological conditions. The drugs are preferably drugs containing an amino group, most preferably peptides and proteins of low or medium molecular weight. Similar molecules are provided wherein a protein carrier or another polymer carrier replaces the PEG moiety.

An implantable neurostimulator system for treating movement disorders includes a sensor, a detection subsystem capable of identifying episodes of a movement disorder by analyzing a signal received from the sensor, and a therapy subsystem capable of applying therapeutic electrical stimulation to treat the movement disorder. The system treats movement disorders by detecting physiological conditions characteristic of an episode of symptoms of the movement disorder and selectively initiating therapy when such conditions are detected.

A system and method are disclosed for identifying monitoring and evaluating hazardous or potentially hazardous conditions. The system-may-be worn-by safety personnel to detect equipment conditions such as low power supply, environmental conditions such as ambient temperature and / or physiological conditions such as heart rate of a wearer. The system may further include a control unit having electronics operable to communicate signals associated with equipment, environmental and physiological conditions.

A method for monitoring physiological conditions of an individual including capturing images according to predefined capture criteria of one or more body regions of the individual on an ongoing basis; transforming the captured images in response to capture conditions present during image capture to provide a normalized image; calculating wellness parameters based on the normalized image; storing system data, including the normalized image, capture parameters, normalization transforms, or wellness parameters, or combinations thereof, monitoring and analyzing the wellness parameters in view of both current and prior semantic data to identify potential changes in physiological conditions; and providing alerts indicative of changes in said physiological conditions of at least one image.

A system and method are disclosed for identifying monitoring and evaluating hazardous or potentially hazardous conditions. The system may be worn by safety personnel to detect equipment conditions such as low power supply, environmental conditions such as ambient temperature and / or physiological conditions such as heart rate of a wearer. The system may further include a control unit having electronics operable to communicate signals associated with equipment, environmental and physiological conditions.

Apparatus and method for the early detection of increased performance impairment, incapacitation or drowsiness of a person, particularly of a person gripping an object such as a steering wheel. A wrist band is worn by the person and an electrical sensor is pressed against the person's skin by the band to sense physiological conditions by detecting various parameters at the wrist and analyzing them to provide an indication of the onset of drowsiness in the person. Some of the parameters analyzed include EMG, temperature, response to stimulation and muscular activity at the wrist. A description of a shock-absorbing wrist monitor is disclosed.

The present application relates to a drug delivery device (100) for delivering liquids to a subject user. More specifically, the drug delivery device provides monitoring facilities of ECG related signals picked up by ECG sensor elements (151) incorporated in or on the housing (101) of the drug delivery device. Additional sensor elements (152) may be included in the drug delivery device to facilitate recording of additional physiological parameters. The drug delivery device may comprise storage capabilities or dedicated signal processing circuitry (120) for analyzing the received signals, and means for providing an output as a response to a detected physiological condition. Other aspects include an optional external device which may provide analyzing circuitry for presenting and displaying of sensor data or identified physiological conditions.

A system for monitoring an individual's physiological condition and detecting abnormalities therein, comprising concurrently receiving at least a first signal and a second signal. The first and second signals are conditioned to minimize background extraneous noise after which, each signal is concurrently processed and analyzed to detect repeating cyclical patterns and further characterized to identify individual components of the repeating cycles. At least one individual component in one signal is selected as a reference marker for a selected component in the other signal. The two signals are then synchronized, outputs produced therefrom and stored in a database. The system is provided with a plurality of devices for acquiring, transmitting and conditioning at least two physiological signals, a software program cooperable with a microprocessor configured for receiving said transmitted signals and conditioned signals, and processing said signals to characterize and synchronize said signals and provide signal outputs derived therefrom, a database for storing said transmitted signals, conditioned signals, synchronized signals, and output signals derived therefrom. The output signals are useful for reporting and optionally for retransmission to the individual's body and providing physiologically stimulatory signals thereto.