19572results about How to "Improve abilities" patented technology

The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human CD20. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.

A carriage assembly for controlling a steering wire steering mechanism within a flexible shaft, for use in gastrointestinal tract surgery, comprises a plurality of selectably engageable motors, including two drive motors for selectably rotating drive shafts of a surgical attachment, two steering motors mechanically communicating with corresponding pulleys around which are coiled directional steering wires communicating with a flexible shaft to enable the selective direction of the flexible shaft within a spatial plane, wherein within the assembly housing the steering motors travel on a steering motor carriage and the pulleys travel on a pulley carriage which is biased by a spring means away from the interior wall of the housing, which biases the steering wires toward a taut state. The bias can be overcome by a carriage motor mechanically communicating with the pulley carriage to cause the flexible shaft to go limp. Also disclosed are a series of surgical attachments which may be coupled to and utilized in conjunction with the carriage assembly.

The methods, devices, and systems are provided for performing endovascular repair of atrioventricular and other cardiac valves in the heart. Regurgitation of an atrioventricular valve, particularly a mitral valve, can be repaired by modifying a tissue structure selected from the valve leaflets, the valve annulus, the valve chordae, and the papillary muscles. These structures may be modified by suturing, stapling, snaring, or shortening, using interventional tools which are introduced to a heart chamber. Preferably, the tissue structures will be temporarily modified prior to permanent modification. For example, opposed valve leaflets may be temporarily grasped and held into position prior to permanent attachment.

An electrosurgical system comprises a radio frequency generator (1), an electrosurgical instrument (E1), and a fluid enclosure (42). The generator (1) has a radio frequency output for delivery of power to the electrosurgical instrument (E1) when immersed in an electrically-conductive fluid. The electrosurgical instrument (E1) has an electrode assembly (32) at the distal end thereof, the electrode assembly comprising a tissue treatment electrode (34), and a return electrode (38) axially spaced therefrom in such a manner as to define, in use, a conductive fluid path that completes an electrical circuit between the tissue treatment electrode and the return electrode. The fluid enclosure (42) is adapted to surround an operation site on the skin of a patient or an incision leading to a cavity surgically created within the patient's body. The fluid enclosure (42) includes sealing means (44) for sealing against the patient's tissue, and the fluid enclosure includes at least one port (50a, 52a) through which the electrosurgical (E1) is insertable, and through which the electrically-conductive fluid can enter and / or leave the enclosure.

A surgical clip applying apparatus comprises an actuator device, a ratchet mechanism, a locking mechanism, and a clip driving device. The actuator device comprises an interior and a cam mechanism disposed therein. The cam mechanism comprises an axial cam surface. The locking mechanism is movable by the actuator device within the interior in a distal direction and in a proximal direction. While moving in the distal direction, the locking mechanism contacts the axial cam surface, thereby causing the locking mechanism to engage the ratchet mechanism to limit movement of the locking mechanism in the proximal direction. Continued movement of the locking mechanism in the distal direction causes the locking mechanism to move off the axial cam surface, thereby enabling the locking mechanism to bypass the ratchet mechanism during a return stroke.

The present invention is an occlusion device having a support hoop. The support hoop increases the ability of the occlusion device to form a seal around the defect and adds additional structural strength to the device by allowing distribution of pressure along a 360° continuum.

A method of facilitating communications and collaboration of a group of plural remote participants comprises steps of receiving information over an information communications network from a first group participant; pushing, over the network to at least one other group participant, an access via an access channel; and allowing the other group participant to access at least some of the received information via said access channel in response to selective activation of the access channel by the other group participant.

A system and method are disclosed for removing a uterus using a fluid enclosure inserted in the peritoneal cavity of a patient so as to enclose the uterus. The fluid enclosure includes a distal open end surrounded by an adjustable loop, that can be tightened, a first proximal opening for inserting an electrosurgical instrument into the fluid enclosure, and a second proximal opening for inserting an endoscope. The loop is either a resilient band extending around the edge of the distal open end or a drawstring type of arrangement that can be tightened and released. The fluid enclosure is partially inserted into the peritoneal cavity of a patient in a deflated condition and then manipulated within the peritoneal cavity over the body and fundus of the uterus to the level of the uterocervical junction. The loop is tightened around the uterocervical junction, after which the enclosure is inflated using a conductive fluid. The loop forms a pressure seal against the uterocervical junction to contain the conductive fluid used to fill the fluid enclosure. Endoscopically inserted into the fluid enclosure is an electrosurgical instrument that is manipulated to vaporize and morcellate the fundus and body of the uterus. The fundus and body tissue that is vaporized and morcellated is then removed from the fluid enclosure through the shaft of the instrument, which includes a hollow interior that is connected to a suction pump The fundus and body are removed after the uterus has been disconnected from the tissue surrounding uterus.

An endoscopic accessory medical device is provided. The device can include a handle, a flexible shaft, and an end effector. The handle can include an actuator for operating the end effector through a wire or cable pulling member that extends through the flexible shaft. The handle and actuator can be operable with a single hand, such that the operation of the end effector can be accomplished with the same hand that is used to hold the handle and advance the end effector through an endoscope. The handle can include an actuation mechanism that is decoupled from operation of the end effector when the actuator is in a first open position, which becomes operatively coupled to the end effector when the actuator is moved to a second position, such as by squeezing the actuator, and which operates the end effector when the actuator is moved further to a third position.

Apparatus and methods for endoscope assemblies having working channels with reduced bending and stretching resistance are disclosed. In one embodiment, an endoscope assembly includes a sheath having a body portion adapted to at least partially encapsulate an endoscopic insertion tube, and a working channel attached to the body portion and extending along at least a portion of the body portion. The working channel includes a component for reducing the resistance of the assembly to bending and stretching. In alternate aspects, the working channel may include a cut, a gap, a sliding portion, or an expansion section. Endoscope assemblies having a working channel in accordance with the invention advantageously reduce the articulation and stretching resistance of the assembly during articulation of the endoscope assembly. Also, because the axial forces (tension and compression) within the working channel are reduced, the working channel can be fabricated out of a relatively hard, inelastic material, thereby reducing the friction within the working channel and improving the physician's ability to perform a medical procedure.

A self-retaining suture has a suture thread less than 1 millimeter nominal diameter. A plurality of retainers is cut into the suture thread using a high accuracy retainer cutting machine. The retainer cutting machine has sufficient accuracy and repeatability to cut consistent and effective retainers at high density on suture threads less than 1 mm nominal diameter.

A surgical system or assembly for performing cardiac surgery includes a surgical instrument; a servo-mechanical system engaged to the surgical instrument for operating the surgical instrument; and an attachment assembly for removing at least one degree of movement from a moving surgical cardiac worksite to produce a resultant surgical cardiac worksite. The surgical system or assembly also includes a motion tracking system for gathering movement information on a resultant surgical cardiac worksite. A control computer is engaged to the attachment assembly and to the motion tracking system and to the servo-mechanical system for controlling movement of the attachment assembly and for feeding gathered information to the servo-mechanical system for moving the surgical instrument in unison with the resultant surgical cardiac worksite such that a relative position of the moving surgical instrument with respect to the resultant surgical cardiac worksite is generally constant. A video monitor is coupled to the control computer; and an input system is coupled to the servo-mechanical system and to the control computer for providing a movement of the surgical instrument. The video monitor displays movement of the surgical instrument while the resultant surgical cardiac worksite appears substantially stationary, and while a relative position of the surgical instrument moving in unison with the resultant surgical cardiac worksite, as a result from the movement information gathered by the motion tracking system, remains generally constant. A method of performing cardiac surgery without cardioplegia comprising removing at least one degree of movement freedom from a moving surgical cardiac worksite to produce at least a partially stationary surgical cardiac worksite while allowing a residual heart section, generally separate from the at least partially stationary surgical cardiac worksite, to move as a residual moving heart part. Cardiac surgery is performed on the at least partially stationary cardiac worksite with a surgical instrument such as needle drivers, forceps, blades and scissors.

A content provider system for enabling content providers to create voice pages with audio files included for use in a network for voice page delivery through which subscribers request a voice page and a voice page server system delivers the voice page audibly to the subscriber. A content provider selects a voice page into which the audio file is to be incorporated, selects the audio file and the content provider system then transfers the audio file to a voice page server system which generates a voice page with the audio file included using XML-based tags designated for audio files. The audio files are uploaded from a number of user devices including a telephony device, a web-based system and a PDA.

A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as Protein A, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for Protein A.

The ability of an ultrasonic system to sweep and lock onto a resonance frequency of a blade subjected to a heavy load at startup is improved by applying a high drive voltage or a high drive current while systematically increasing the level of the applied signal. Increasing the drive signal to the hand piece results in an improved and more pronounced “impedance spectrum.” That is, under load, the increased drive signal causes the maximum phase margin to become higher and the minimum / maximum impedance magnitude to become more pronounced. Increasing the excitation drive signal to the hand piece / blade at startup significantly alleviates the limiting factors associated with ultrasonic generators, which results in an increase of the maximum load capability at startup.

An electronic camera for producing an output image of a scene from a captured image signal includes: (a) a first imaging stage comprising a first image sensor for generating a first sensor output; a first lens for forming a first image of the scene on the first image sensor; and a first lens focus adjuster for adjusting focus of the first lens responsive to a first focus detection signal; and (b) a second imaging stage comprising a second image sensor for generating a second sensor output; a second lens for forming a second image of the scene on the second image sensor; and a second lens focus adjuster for adjusting focus of the second lens responsive to a second focus detection signal. A processing stage either (a) selects the sensor output from the first imaging stage as the captured image signal and uses the sensor output from the second imaging stage to generate the first focus detection signal for the selected imaging stage, or (b) selects the sensor output from the second imaging stage as the captured image signal and uses the sensor output from the first imaging stage to generate the second focus detection signal for the selected imaging stage.

Bifurcated delivery assemblies provide bilateral access to first and second branch lumens extending from a main body space or lumen in a patient. One or more interventional devices are combined with the delivery assemblies for delivery s into one or both of the branch lumens. Bilateral renal stenting or embolic protection procedures are performed using the combination delivery / interventional device assemblies. Fluids may also be injected or aspirated from the assemblies. A bifurcated catheter has a first fluid port located on one bifurcation branch, a second fluid port located on a second branch of the bifurcation, and a third fluid port positioned so as to be located within a vena cava when the first and second ports are positioned bilaterally within first and second renal veins.

The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.

A monitor device and associated methodology are disclosed which provide a self contained, relatively small and continuously wearable package for the monitoring of heart related parameters, including ECG. The detection of heart related parameters is predicated on the location of inequipotential signals located within regions of the human body conventionally defined as equivalent for the purpose of detection of heart related electrical activity, such as on single limbs. Amplification, filtering and processing methods and apparatus are described in conjunction with analytical tools for beat detection and display.

A patient-side surgeon interface provides enhanced capabilities in using a minimally invasive, teleoperated surgical system. The patient-side surgeon interface has components within the sterile surgical field of the surgery. The components allow a surgeon to control teleoperated slave surgical instruments from within the sterile surgical field. The patient-side surgeon interface permits a surgeon to be in the sterile surgical field adjacent a patient undergoing surgery. Controlling minimally invasive slave surgical instruments from within the sterile surgical field permits minimally invasive surgery combined with direct visualization by the surgeon. The proximity to the patient allows the surgeon to control a teleoperated slave surgical instrument in tandem with controlling manually controlled instruments such as a laparoscopic instrument. Also, the surgeon, from within the sterile surgical field, can use the patient-side surgeon interface to control at least one proxy visual in proctoring another surgeon.

The present invention relates generally to a non-invasive method and apparatus for measuring a fluid analyte, particularly relating to glucose or alcohol contained in blood or tissue, utilizing spectroscopic methods. More particularly, the method and apparatus incorporate means for detecting and quantifying changes in the concentration of specific analytes in tissue fluid. Also, the method and apparatus can be used to predict future levels of analyte concentration either in the tissue fluid or in blood in an adjacent vascular system.