456 results about "Heavy chain" patented technology

A heavy chain is the large polypeptide subunit of a protein complex, such as a motor protein or antibody. It commonly refers to the immunoglobulin heavy chain. The heavy chain is the larger of the two types of chains that comprise a normal immunoglobulin or antibody molecule. The heavy chain portion of an antibody contains 2 regions; the Fab and Fc. Amino acid sequence determines the type of heavy chains, and heavy chains define the isotype of Ig. Immunoglobulin G has γ gamma heavy chains, IgA has α alpha heavy chains, IgM has μ mu heavy chains, IgD has δ delta heavy chains, and IgE has ε epsilon heavy chains. In contrast, all light chains are either κ kappa or λ lambda light chains, either of which may be found on any Ig molecule, regardless of isotype. Each Ig unit is made up of 2 heavy chains, 2 light chains, and has 2 antigen-binding sites. Heavy chain is joined with the light chain with the help of disulphide bond.