53 results about "Immune state" patented technology

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating triple negative breast cancer and application thereof. The traditional Chinese medicine composition is prepared from the following main active ingredients in parts by mass: 20 to 40 parts of radix astragali seu hedysari, 10 to 20 parts of rhizoma curcumae, 10 to 20 parts of herba hedyotidis diffusae, 5 to 15 parts of fructus aurantii immaturus, 5 to 15 parts of radix bupleuri, 5 to 15 parts of radix paeoniae alba and 5 to 15 parts of liquorice root. Animal experiments show that the traditional Chinese medicine composition can significantly inhibit tumor growth and pulmonary metastasis of triple-negative breast cancer tumor-bearing mice, increase the proportion of CD8 + T lymphocytes in blood, reduce the proportion of MDSCs, significantly down-regulate the expression of pro-inflammatory cytokines such as IL-6, IL-1alpha, CXCL1 and GM-CSF in serum, and cooperate with PD-L1 immunotherapy to achieve a synergistic effect. And the whole blood and liver and kidney function indexes are in a normal range. Therefore, the traditional Chinese medicine composition disclosed by the invention can be used for effectively inhibiting the tumor growth and pulmonary metastasis of the triple negative breast cancer, remodeling the immune state of an organism and reducing the release of proinflammatory factors, and is safe, reliable, free of obvious liver and kidney toxicity and blood toxicity and small in side effect.

The invention discloses application of CD146 + umbilical cord mesenchymal stem cell subpopulation in preparation of drugs for preventing and treating immune thrombocytopenia and a product, and relates to the technical field of biology. The invention provides an application of a CD146 + mesenchymal stem cell subset in preparation of a medicine for treating or preventing immune thrombocytopenia. The CD146 < + > mesenchymal stem cell subpopulation can increase the number of platelets of ITP patients, regulate the CD4 < + > / CD8 < + > ratio of the ITP patients and remarkably reduce the MDSC proportion, so that the in-vivo immune state is changed.

The invention discloses a marker for predicting the curative effect of tumor immunotherapy as well as application and a detection method of the marker, and belongs to the technical field of biomedicine. The marker is glycerophosphorylcholine (GPC) in peripheral blood, and under the condition that the GPC level of peripheral plasma is low, it is judged that ICIs immunotherapy is poor in curative effect response. Peripheral blood samples are simple and noninvasive to obtain, longitudinal curative effect monitoring can be realized, the method is independent of tissue biopsy and is not influenced by tumor heterogeneity, the cost is reduced, and application is facilitated; meanwhile, peripheral blood not only objectively reflects the systematic immune state of a host, but also is closely related to tumor immunity as an important ring in a tumor immune cycle, and in the aspect of accuracy, the efficiency of a prediction model constructed by GPC reaches 0.886 and is remarkably higher than that of PDL1.

To provide an immune state prediction system capable of predicting a future immune state by grasping not only a conventional medical examination and life habit but also a factor of the immune state and genetic information.SOLUTION: An information processing apparatus includes an acquisition unit that acquires state data including at least genetic information of a user and execution data of the user, a learning model creation unit that learns execution data of the user having the state data in association with each other and generates a learning model for predicting an immune state of the user with respect to predetermined state data, a prediction unit that outputs immune state prediction data obtained by predicting an immune state on the basis of the learning model from newly acquired state data, a difference between the immune state prediction data and execution data of the user having the immune state prediction data, and a provision unit that provides at least one of the state data, the execution data, the immune state prediction data, and the analysis data to a user and / or a third party company.SELECTED DRAWING: Figure 1

[Problem] To make it possible to predict an immune state in the future by assessing a factor of an immune state as well as an existing health examination and a lifestyle habit. [Solution] An immune state prediction provision system 1 is configured such that at least one item of state data associated with an immune state which is selected from a sleep state, a motion state, a lifestyle habit state, a life state, a work state and a meal state is acquired, then a learning model that generates immune state prediction data is produced from the acquired state data, and then the immune state is predicted on the basis of the learning model from newly acquired state data. Subsequently, the difference between the immune state prediction data and execution data such as the results of a health examination and the results of an immunity test is analyzed to produce analysis result data, and the analysis result data is output. In addition, at least one item of data selected from the state data, the immune state prediction data, the execution data and the analysis result data are provided for a user or a third person.

The application relates to a detection method of anti-preS1 antibody, an anti-preS1 antibody detection kit and application, the application carries out multi-sequence comparison and conservation analysis on preS1 sequences of different genotypes (A, B, C, D and CD mixed type) of HBV, takes type A (AB697487.1), type C (FJ032351.1) and type D (LC519808.1) as reference sequences, based on the sequence consistency standard of 85% of full length and 90% of the key region of functional antibody binding, a highly conservative preS1 full-length antigen sequence is systematically screened out in natural variation, the sequence can cover antigen variation of A-D type HBV, and the sequence is taken as a coating antigen to establish an indirect ELISA detection system, a good linear relationship is presented in the range of 4.88-625 ng / mL, and the Cut-off value is 33.6 ng / mL; clinical verification shows that the method can effectively distinguish chronic hepatitis B patients from healthy control groups, compared with detection methods based on partial fragments or overlapping short fragments, the false negative rate can be significantly reduced, and the method is suitable for HBV infection immune state evaluation, anti-virus curative effect monitoring and prognosis analysis.

The present application provides a method for identifying the immune state of a subject, and a use of a reagent for detecting an IL-1R2 level in a sample from a subject in the preparation of products for identifying the immune state of the subject. The present application further provides an antibody that binds to human IL-1R2 and a use thereof, and a hybridoma cell producing the antibody that binds to human IL-1R2 and a use thereof.

Provided are a difference quantification comparison method for an adaptive immune system, and the use thereof. The method comprises obtaining at least one of a BCR heavy chain sequence of a B cell, a BCR light chain sequence of the B cell and a TCR β chain sequence of a T cell of a sample to undergo comparison, and sequencing same; comparing the determined sequence with a gene sequence in the IMGT database to obtain sequence annotation information of the corresponding sequence, and further constructing a 3D graph displaying the adaptive immune condition of the sequence; then by means of using a minimum transformation cost method, quantifying an immune state difference between samples to be tested and between a sample to be tested and the database that has undergone the test. The method for quantifying immune differences can be used for evaluating the immune state of biological samples, and can also be used for evaluating influences of various therapy and intervention methods on the immune system, so as to judge the effects of the therapies and interventions, including but not limited to the drug efficacy, the vaccine efficacy, etc.

The application discloses a livestock breeding poultry quarantine sampling device, and particularly relates to the technical field of poultry quarantine sampling, and comprises a positioning disc, a positioning sampling assembly is arranged on the positioning disc, the positioning sampling assembly comprises a swivel ring arranged on one side of the positioning disc, a screw rod capable of being displaced up and down is slidly connected to the middle part of the swivel ring, and a top disc is movably connected to the top end of the screw rod. The application effectively removes interfering substances in the sample, avoids the influence of impurities on subsequent pathogen detection results, improves the reliability of quarantine data, and improves the accuracy and comprehensiveness of quarantine results. The blood sample is used for detecting pathogen antibodies, immune state and other indexes, and the fecal sample is used for checking intestinal pathogens, parasite eggs and the like. The two types of samples are complementary and verified, the accuracy and comprehensiveness of the quarantine results are greatly improved, and the problem that a single sample cannot comprehensively judge the health status of poultry is effectively solved.

The application relates to the field of medical diagnosis, and particularly discloses a biomarker combination, a kit and application thereof for HIV / Mtb co-infection immune state evaluation and clinical diagnosis. Peripheral blood samples of HIV infectors, Mtb infectors and HIV / Mtb co-infectors are subjected to multi-factor detection, and Lasso regression is adopted to screen out cytokines such as FGF-2, IL-7, I-309, TNF-alpha, MMP-1 and MMP-7 closely related to HIV / Mtb co-infection, so as to construct a multi-factor diagnosis model. The model shows high sensitivity, specificity and AUC value in the training set and the test set, can effectively distinguish HIV single infection from HIV / Mtb co-infection individuals, and is particularly suitable for the diagnosis of patients with low CD4 + T cell level. The biomarker combination and the kit prepared by the biomarker combination provided by the application can be used as a supplement to immunological detection methods, and provide a new technical means for the clinical diagnosis and immune state evaluation of HIV / Mtb co-infection.

The invention discloses a method for evaluating gastric cancer prognosis by using peripheral blood inflammation related markers, and belongs to the technical field of smart medical treatment. The method comprises the following steps: firstly, constructing an immune state model based on a ratio of neutrophil to lymphocyte and a ratio of platelet to lymphocyte, and outputting an immune state coefficient; constructing a nutrition state model based on serum albumin, globulin concentration and ratio of albumin to globulin, and outputting a nutrition state coefficient; then combining the coefficients with the serum IL-35 and IL-37 concentrations to construct an inflammation risk model, and outputting an inflammation risk coefficient; meanwhile, a behavioral environment state model is constructed based on the daily salt intake and the smoking age limit of the patient, and a behavioral environment state coefficient is output; and finally, integrating the inflammation risk coefficient, the behavior environment state coefficient and the prognosis nutrition index, and obtaining a prognosis evaluation coefficient through a prognosis state evaluation model. Through multi-dimensional and non-invasive index integration and modeling analysis, accurate, economic and convenient evaluation of gastric cancer prognosis is realized.

The invention belongs to the technical field of medicine, and discloses an application method of tumor-killing effect B cells in colorectal cancer liver metastasis, Meta-CBL is used for transforming the B cells into tumor-killing effect cells for the first time, and the anti-tumor immune effect is remarkably enhanced. In a tumor microenvironment, the meta-CBL can directly kill tumor cells and activate other effector immune cells, so that synergistic anti-tumor is realized. By combining liquid biopsy and single cell sequencing, tumor load and microenvironment immune state can be tracked in real time. The evaluation precision is higher than that of traditional iconography, invalid treatment patients can be recognized in the early stage, and the treatment strategy is adjusted in time. Precise treatment and dynamic prognosis evaluation of colorectal cancer liver metastasis are realized by innovatively utilizing meta-CBL, and the defects of limited treatment effect and lagging evaluation means in the prior art are overcome. The comprehensive system structure and the precise treatment strategy of the system bring brand new treatment choices and remarkable survival benefits for patients with colorectal cancer liver metastasis, and the system has extremely high industrialization and clinical popularization value.

The invention relates to a kit for simultaneously detecting angiogenesis and plasma cell infiltration in lymphatic tissue and a preparation method and application of the kit, the kit comprises quantum well-antibody conjugates CQWs-525-VEGF, CQWs-525-ACTA2 and CQWs-585-CD138 and CQWs-625-Mum1, and the kit can be used for staining a lymphatic tissue section; by marking expression conditions of VEGF, ACTA2, CD138 and Mum1, the angiogenesis and plasma cell infiltration degree in the lymphatic tissue is evaluated. The quantum sheet has the characteristics of wide absorption spectrum, narrow light-emitting spectrum, high brightness and difficulty in quenching, and is used for marking blood vessels and plasma cells in tissues after being coupled with an antibody, so that quantitative analysis can be realized and spatial position distribution can be observed at the same time, the immune microenvironment of the tissues can be more accurately and effectively detected, and the immune state and immune function of the organism can be further evaluated.

The invention discloses a livestock breeding poultry quarantine sampling device, and particularly relates to the technical field of poultry quarantine sampling, the livestock breeding poultry quarantine sampling device comprises a positioning disc, the positioning disc is provided with a positioning sampling assembly, the positioning sampling assembly comprises a rotating ring arranged on one side of the positioning disc, and the middle part of the rotating ring is slidably connected with a screw rod capable of moving up and down; the top end of the lead screw is movably connected with a top disc. Interference substances in samples are effectively removed, impurities are prevented from influencing subsequent pathogen detection results, the reliability of quarantine data is improved, blood samples are used for detecting pathogen antibodies, immune states and other indexes, excrement samples are used for checking intestinal pathogens, parasitic ova and the like, the two samples are subjected to complementary verification, and the detection accuracy is improved. The accuracy and comprehensiveness of quarantine results are greatly improved, and the problem that the poultry health state cannot be comprehensively judged by a single sample is effectively solved.

The invention relates to the technical field of genetic engineering and pharmaceutical preparations, in particular to a hydrogel drug delivery system carrying recombinant protein for cancer treatment and a preparation method of the hydrogel drug delivery system, the hydrogel drug delivery system comprises recombinant plasmids, the recombinant plasmids are protein pcDNA3.4-PD1-ECD-CCL5 with an amino acid sequence, and the amino acid sequence of the protein is Pab-CCL5. According to the present invention, the recombinant plasmid can express the fusion protein of PD1-ECD-IgG1 and CCL5-IgG1, and the recombinant protein Pab-CCL5 prepared by using the recombinant plasmid has good anti-tumor effect, can change the immune state of the tumor microenvironment, and can reshape the tumor microenvironment; immune cells expressing CCL5 receptors are recruited, and the anti-tumor immune response of the body is improved; the compound kills tumor cells through multiple mechanisms including innate immunity and adaptive immunity, is a potential candidate drug for treating prostate cancer, breast cancer and PD-L1 expression cancer, and is free of cytotoxicity.

The invention discloses an integrated computer system for immune state analysis, and belongs to the technical field of immune detection. According to the method, first sequencing data of a T cell receptor of a to-be-detected user are obtained, second sequencing data of a T cell receptor of a historical user before the current moment are obtained, a first undirected weighted graph is constructed according to the first sequencing data, and data vertexes of the first undirected weighted graph are CDR3 clone types of the first sequencing data and CDR3 clone types of the second sequencing data. The data edge of the first undirected weighted graph is the similarity of a CDR3 clone type, and the CDR3 clone type is a unique CDR3 beta amino acid sequence clone type, determining a first analysis feature according to a graph clustering algorithm and the first undirected weighted graph, and determining the immune state of the to-be-detected user according to the first analysis feature and the second analysis feature corresponding to the second sequencing data. The method has the beneficial effect of improving the accuracy of immune state analysis.

The invention discloses an application of DL-endopeptidase in preparation of a synergist of an immune checkpoint inhibitor, and the DL-endopeptidase has an amino acid sequence as shown in SEQ ID NO.1 or has a DNA (deoxyribonucleic acid) sequence as shown in SEQ ID NO.2. The invention further discloses a preparation method of the DL-endopeptidase. The application confirms that the DL-endopeptidase can be used as a synergist, can be combined with an immune examination inhibitor for use, is used for activating the immune state of a patient and improving the response of ICB, and is beneficial to expanding the applicable crowd of ICB.

The application discloses a pig intestinal lactobacillus salivarius with antimicrobial activity and application thereof, relates to the technical field of microorganisms, and is named pig-LS2023. The strain can produce specific surfactants, the surfactants have antibacterial and antiviral activities, and have the advantages of biodegradability, non-toxicity and stability. The results of antimicrobial experiments show that the inhibition rates of the produced surfactants on pig escherichia coli and streptococcus are 95.06% and 81.80% respectively, and the surfactants have obvious inhibitory effect on PCV2. The research results show that the pig-LS2023 strain is expected to become a candidate probiotic strain for improving the immune state of pigs and producing a new type of anti-infection drug substitute.

The invention provides a single-tube multi-allergen specific basophilic granulocyte detection method based on multicolor flow cytometry, and belongs to the technical field of immunodetection. Through a single-tube multicolor flow cytometry technology, rapid and synchronous quantitative analysis of various allergen-specific basophilic granulocytes in peripheral whole blood is realized, and the detection efficiency and flux are remarkably improved; the method is easy and convenient to operate, small in needed sample size and especially suitable for children and other people with blood sampling difficulty, and the limitation of clinical application is greatly reduced; by directly measuring cell populations closely related to anaphylaxis, a more intuitive and reliable auxiliary diagnosis basis is provided for IgE-mediated anaphylaxis diseases, the immune state change of a patient in the treatment process can be effectively monitored, and a new technical support is provided for clinical precise intervention and curative effect evaluation.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.

The application discloses a kind of for in-vivo tumor microenvironment magnetic heat immune closed loop system and control method, belong to biomedical engineering and nanotechnology cross field.For the existing magnetic heat therapy technology cannot carry out real-time self-adaptive regulation according to the dynamic change of GAL-1, IFN-gamma, IL-4 and Th1 / Th2 ratio in tumor microenvironment, easy to cause the problem that immune marker deviates from window, a kind of magnetic heat immune closed loop regulation system is proposed.Firstly, baseline value is obtained and target concentration window is set;Control alternating magnetic field to activate vortex magnetic iron oxide nanoparticles to generate heat and active oxygen;Real-time acquisition of immune marker concentration fed back by implantable electrochemical sensor, dynamically adjust field strength and / or frequency;With single effective activation window, maximum single time length, temperature as stop criterion;After stop, standby and pulse reset.Real-time self-adaptive regulation of in-vivo immune state is realized, immune activation deficiency or immune marker deviation from window is avoided, and normal tissue thermal damage is prevented by multi-level thermal safety constraint.

The present invention relates to an autoantigen-specific nanofusion vaccine composition for the treatment of systemic sclerosis, the composition being for simultaneous immunomodulation and antifibrosis. A nanofusion body carrying a vimentin peptide according to the present invention was found to inhibit tissue fibrosis in systemic sclerosis, reduce the amount of autoantibodies in serum, and regulate the expression of immune-regulatory cells and pathogenic cells associated with systemic sclerosis. The nanofusion body was also found to inhibit tissue fibrosis and to exhibit enhanced anti-fibrotic effects, when co-administered with a vimentin antibody, in an animal model reflecting the immune status of systemic sclerosis patients. In addition, the nano-vaccine was found to decrease the expression of fibrotic and pathogenic factors in tissues and was also found to improve disease activity not only in vimentin-specific systemic sclerosis but also in infection-associated systemic sclerosis.

The application discloses an immune dynamic trajectory modeling method and system, which solves the problems that the prior art cannot accurately locate the inflection point of the change of the immune parameter with age, cannot comprehensively evaluate the immune state of multiple parameters, and lacks visual dynamic trajectory output. The method comprises the following steps: collecting multiple lymphocyte subpopulation parameters in peripheral blood; detecting the trend of each immune parameter with age, calculating the change slope before and after each inflection point; dimension reduction and weighting are performed on multiple immune parameters to construct a comprehensive immune index (CII); and a dynamic trajectory graph containing the inflection point age of each immune parameter, the change slope and the comprehensive index trend graph is output. The application integrates flow cytometry detection data, piecewise regression model and principal component analysis model, can intuitively display the nonlinear and multi-stage characteristics of the evolution of the immune system with age, identify the key aging inflection point, and provide a quantitative tool for population immune state screening, aging mechanism research and drug or nutrition intervention effect evaluation.

The application discloses a kind of sea fish mycobacterium infection mouse model based on T cell immune state difference and its construction method and application.The method under unified infection condition (bacterial amount 1×10 4 CFU, temperature 25 DEG C, time 4 weeks), respectively, constructs the infection model of congenital T cell immune deficiency nude mouse and the thymus pentapeptide processing mouse model of acquired T cell immune regulation, by comparing and analyzing the infection phenotype and pathological changes under different immune states, for the mechanism of T cell immunity in non-tuberculous mycobacterium infection, screening immune regulation treatment drug provides standardized experimental model.

This invention relates to a diagnostic kit for assessing transplant rejection status, belonging to the field of biomedical technology. The invention obtains data on the relative proportions and absolute counts of various immune cell populations in peripheral blood, and measures the ultrasound hemodynamic parameters of the transplanted kidney, including the interlobar artery resistance index and the renal aortic resistance index. It then uses the formula y1 = -1.228a + 0.008b – 0.009c to determine whether acute rejection exists. In the formula, the donor kidney type is defined as variable a, with living donor kidney = 0 and deceased donor kidney = 1; the absolute value of peripheral blood CD4 is defined as a continuous variable b; the absolute value of peripheral blood CD8 is defined as a continuous variable c; and when y1 > 0.5, acute rejection is determined. This invention makes the diagnosis of the immune status of transplanted kidneys non-invasive, optimizing the kidney transplant diagnosis and treatment process.

The invention relates to a method for evaluating the immune state of obese people and a kit thereof, relates to the technical field of medical data mining, and comprises an index combination for evaluating the immune state of the obese people. The index combination comprises the following indexes: hematocrit (HCT), hemoglobin content (HGB), low membrane potential percentage (Ts.MMPlow%) of killer T cells, percentage (T4Tcm%) of central memory assistant T cells, low membrane potential percentage (T8Tn.MMPlow%) of pure killer T cell mitochondria, percentage (NKT.NKG2D +%) of NKT cell expression NKG2D and mitochondrial mass (T8Tcm. MM) of central memory killer T cell mitochondria. The index combination obtained through screening has high biological interpretation and clinical correlation, and the immune state of obese people can be effectively evaluated.

The invention provides a method for drawing a sepsis immune cell dynamic change map and application, and belongs to the technical field of sepsis treatment. On the basis of the scRNA-seq technology, the immune library is constructed, the immune microenvironment is more comprehensively analyzed by adopting the scVDJ-seq sequencing technology, the cloning source of a single cell can be accurately monitored, the proliferation, differentiation and mutation paths of the cloned cell can be reconstructed, and the microenvironment with the immune function change can be more accurately obtained. The map drawn by the method can allow clinical workers to more accurately evaluate the immune state of the patient through related marker genes, so that dynamic change capture can guide the treatment opportunity of immune regulation of the sepsis patient in clinic, and accurate treatment of the sepsis immune function can be realized.

The invention discloses a feed for promoting piglet growth and protein deposition, and belongs to the technical field of animal nutrition. The feed is a complete formula feed with the standard ileum digestible protein level of 13.2%-16.4%, and contains 0.1%-1.0% of a composite functional additive. The additive is composed of 10%-30% of coated sodium butyrate, 5%-15% of a lactobacillus probiotic preparation, 3%-10% of yeast beta-glucan, 2%-8% of a nucleotide mixture, 8%-20% of glutamine, 1%-5% of acid protease and a carrier. Through the synergistic effect of the additive and the low-protein daily ration, the intestinal health, nutrient substance digestion and absorption and immune states of piglets are comprehensively improved, so that the technical effects of improving the feed efficiency, promoting body protein deposition and reducing the diarrhea rate are achieved while the protein level of the daily ration is reduced and the cost is saved.

The application provides a composition for clinical diagnosis and treatment of hematological malignancies. The composition is obtained by database acquisition of TCR and BCR rearrangement specific primer fragments, and a primer set suitable for human immune library multiplex PCR is established, which can perform multiplex amplification on CDR3 sequences and incomplete rearrangement sequences. The multiple detection index primers include IGH, IGDH, IGK, IGL, TRB-VJ, TRB-DJ, TRG, TRD. Further research shows that the primer set can perform clinical multi-index detection in various hematological malignancies, can significantly improve the positive detection of clinical samples, can comprehensively detect the immune library of individual patients, realize high-sensitivity MRD tracking, and also can help obtain all abnormal clones of the body and accurately reflect the immune status of the body.

The application relates to an intraoperative intervention measure evaluation method and device based on a generative adversarial network. The method first encodes an intraoperative electroencephalogram signal into a neural disturbance field by introducing a space-time encoder, effectively capturing the space-time propagation mode of a nociceptive stimulus in the brain; then, a generative adversarial network is used to predict a postoperative immune state vector trajectory, capturing the mapping relationship between the neural imprint and the immune imprint left by the nociceptive stimulus in different space-time modes during the operation; then, two different postoperative immune state vector trajectories with and without intervention measures are predicted, the effects of different intervention measures can be simulated and quantitatively compared, so as to assist doctors in optimizing the postoperative recovery and long-term prognosis of patients. The application deeply excavates the space-time characteristics of the intraoperative neural signal, dynamically predicts the postoperative immune state by combining the generative adversarial network, and introduces an intervention operator to simulate the intervention effect, thereby providing an innovative way of prospectively and quantitatively evaluating the effect of intraoperative intervention measures.