59results about How to "Effective combination" patented technology

The application discloses a forming die and process of a U-shaped pressure relief separation guard plate with multiple T-shaped reinforcing ribs, relates to the technical field of composite material forming, and discloses the following technical scheme: the forming die comprises a male die, an outer female die, an integral lateral pressing block, multiple reinforcing rib split pre-paving blocks and reinforcing rib split connecting beams; each of the reinforcing rib split pre-paving blocks is provided with a T-shaped connecting groove; the reinforcing rib split connecting beams pass through the T-shaped connecting grooves in sequence to connect and fix the reinforcing rib split pre-paving blocks into a combined pressing block; the U-shaped main body formed by the integral lateral pressing block and the combined pressing block is placed at a die position of the male die; and the integral lateral pressing block and the combined pressing block are provided with the outer female die at the periphery. The application has high integral strength, high reliability and good stability, does not need a post-assembly process, greatly reduces production cost, is suitable for batch production of products, and has a wide application prospect.

The invention provides an acetabular prosthesis which comprises an acetabular cup, an acetabular prosthesis body and an acetabular prosthesis body, and a containing part communicated with the outer surface of the acetabular cup is arranged in the acetabular cup; the outward-extending fixing piece is movably arranged in the containing part and is provided with a fixing position extending out of the acetabular cup and an avoiding position located in the containing part, and an acute-angle included angle or a right-angle included angle is formed between the moving direction of the outward-extending fixing piece and the axis of the acetabular cup; and the operating part is arranged on the acetabular cup and is in driving fit with the overhanging fixing part, so that the overhanging fixing part is switched between the fixing position and the avoiding position. According to the technical scheme, the problem that the acetabular cup fixing effect is poor in the prior art is effectively solved.

To address the issues of insufficient performance and high cost associated with integral casting and additive manufacturing methods for parts with small-entry elliptical gradient deep cavities, and the difficulties, low efficiency, and high cost of metal removal methods, this invention proposes a machining method for elliptical gradient deep cavities with small entry points. The method involves first rough drilling and rough turning to obtain a deep hole. Then, a step-by-step machining approach is adopted, dividing the part into regions and machining them axially and radially. First, the part is tilted to machine the regions on both sides of the major axis of the ellipse. Then, the part is turned upright to machine the regions on both sides of the minor axis of the ellipse. During the upright machining, a radial layering and thin-cutting fast-running method is used. Several layers are machined using the first toolpath until the machining residue in the undercut and triangular regions is removed. Then, a second toolpath is used for contour machining to obtain a gradient deep cavity with an elliptical cross-section. Finally, the gradient deep cavity is precision milled until its internal dimensions and surface roughness meet the design requirements.

The utility model discloses a spraying system of a spraying tower, which relates to the waste gas treatment technology, and adopts the technical scheme that the spraying system comprises a tower body, a spraying pipe and a nozzle, the spraying pipe comprises a main pipe and a branch pipe, the nozzle is rotatably connected to the branch pipe, a rotating piece is arranged in the nozzle, and the nozzle is provided with an atomizing opening and a liquid flow opening. The spray head starts to rotate under the action of the rotating part, the treatment liquid in the spray head is sprayed out from the atomization opening and the liquid flow opening under the action of liquid pressure, the treatment liquid sprayed out from the liquid flow opening is large in particle diameter and can effectively combine pollutants with large diameters in waste gas, the treatment liquid sprayed out from the atomization opening is small in particle diameter, and the pollutants can be effectively combined with the pollutants with large diameters in the waste gas. The spray tower is simple in structure, large in dispersion area and longer in hang time, and can be fully combined with pollutants with smaller diameters in waste gas, and meanwhile, as the rotation of the spray head can provide centrifugal force for the treatment liquid leaving the spray head, the treatment liquid sprayed out of the atomization port and the liquid flow port can have wider coverage area, and the working efficiency of the spray tower is improved.

The application provides a light-assisted charging aqueous zinc ion battery and a preparation method thereof, and provides a light-assisted charging aqueous zinc ion battery, which comprises a light cathode, a diaphragm, an electrolyte, a zinc anode and a battery shell, the light cathode is a vanadium oxide compound light cathode, the zinc anode is a metal zinc sheet, the electrolyte is a zinc salt aqueous solution, and the light-assisted charging aqueous zinc ion battery is packaged in a battery shell with a cathode side opening, the vanadium oxide compound light cathode and the metal zinc sheet anode are separated by a diaphragm, and the diaphragm is filled with electrolyte on both sides. The application can realize the light-assisted charging aqueous zinc ion battery which can collect solar energy and store at the same time, and improve the electrochemical performance of the aqueous zinc ion battery.

The application discloses an ISR inhibitor and a preparation method and application thereof, and belongs to the technical field of biological medicines. The compound of the application is a compound with the structure of formula (I) or formula (II), a stereoisomer thereof, a geometric isomer thereof, a tautomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof or a solvate thereof. The compound provided in the application can be effectively combined with eIF2B, has good ATF4 inhibiting capacity, and can better restore protein synthesis when ISR is stimulated. Therefore, the compound of the application can be used as an ISR inhibitor and for treating various related diseases.

The present invention relates to a specific binding protein targeting PD-L1 and CD73, wherein the specific binding protein is capable of specifically binding to PD-L1 and / or a fragment thereof, and CD73 and / or a fragment thereof. The present invention further relates to use of the specific binding protein in the treatment, prevention and / or diagnosis of diseases such as immune diseases, acute and chronic inflammatory diseases, and tumor diseases.

The application provides a bispecific antibody and application thereof, and the antibody is a double-chain antibody, which comprises a first peptide chain and a second peptide chain, wherein the first peptide chain comprises a CD3 single-chain antibody and a first Fc region, and the CD3 single-chain antibody comprises a heavy chain variable region and a light chain variable region; the second peptide chain comprises a TIGIT extracellular region and a second Fc region; the C terminal of the CD3 single-chain antibody is connected with the N terminal of the first Fc region; and the C terminal of the TIGIT extracellular region is connected with the N terminal of the second Fc region. The prepared bispecific antibody can simultaneously target CD3 and CD155, thereby mediating the killing of tumor cells by T cells, and has strong tumor inhibition capacity.

The application relates to a reconfigurable computing architecture for neural network calculation, comprising a multiple-precision multiply-accumulate array, an input buffer, a weight buffer and a control unit; the multiple-precision multiply-accumulate array comprises a plurality of latches and a plurality of computing units; the control unit is used for determining target weight data required by current calculation from weight data stored in the weight buffer, and loading the target weight data into each latch of the multiple-precision multiply-accumulate array; the input buffer is used for storing input data; the control unit is further used for determining target input data required by current calculation from the input data stored in the input buffer, and transmitting the target input data to the multiple-precision multiply-accumulate array; and the multiple-precision multiply-accumulate array is used for performing calculation according to the target weight data and the target input data stored in each latch by using each computing unit based on calculation precision, so as to determine a calculation result. The computing architecture provided by the application can improve calculation efficiency.

The application discloses a specific molecular marker combination, a primer probe group, a kit and application thereof for identifying artificial Ophiocordyceps sinensis and wild Ophiocordyceps sinensis in the Tibet Autonomous Region, and the molecular marker combination comprises SNP1, SNP2 and SNP5; the SNP1 is located at the 339bp position of the nucleotide sequence shown in SEQ ID NO:1, and the polymorphism is C or T; the SNP2 is located at the 354bp position of the nucleotide sequence shown in SEQ ID NO:1, and the polymorphism is A or C; and the SNP5 is located at the 398bp position of the nucleotide sequence shown in SEQ ID NO:1, and the polymorphism is G or T. The molecular marker combination of the application scheme can be effectively used for distinguishing the artificial Ophiocordyceps sinensis and the wild Ophiocordyceps sinensis in the Tibet Autonomous Region.

This invention relates to the field of heterogeneous catalysis technology in chemical engineering, specifically to a highly active catalyst for the direct synthesis of dimethyl carbonate from methanol and carbon dioxide. The catalyst is CeO2 derived from Ce-MOF, with a Taylor ratio of 0.15-0.35. Using acidic Ce-MOFs as a cerium precursor, this catalyst leverages their ordered pore structure, large specific surface area, and superior adsorption capacity to achieve the resorption of metal ions (CeO2, MgO, MgO, MgO, MgO) by... 3+ Ce 4+ The high dispersion of the catalyst in Ce-MOF, and the addition of appropriate hydroxides can reduce the adsorption of non-reactive substances, thereby significantly improving the catalytic activity of the catalyst.

The utility model relates to the field of ancient architecture gardens, especially a flower box type arched gate. The arched gate contains four vertical supports (2), and the upper portion of the four vertical supports (2) is an upper top support (1); the four vertical supports (2) contain a plurality of layered plates (3) arranged at intervals; each layered plate (3) is arranged with a bolt hole (6) at four corners; the arched gate further contains a flower box (5), the bottom of the flower box (5) can be installed on the bolt hole (6) through a bolt; the middle portion of the four vertical supports (2) is a door opening space (4); a plurality of flower boxes (5) are built between the plurality of layered plates (3) on both sides of the door opening space (4); the flower box (5) is arranged with a waterproof cloth, the waterproof cloth has soil, and the soil has green plants. The flower box and the vertical support (2) are combined, and the flower box and the arch gate can be effectively combined.

This invention provides a geological steering method for horizontal wells in tight sandstone gas reservoirs. First, relevant data from the target well and adjacent wells are acquired. Then, using this data, the geological characteristics of the target sandstone body, its micro-structure, reservoir heterogeneity, and stratigraphic occurrence are determined. Next, using well logging interpretation from adjacent wells and geophysical channel characterization, a refined three-dimensional geological model based on seismic constraints is established to clarify the sandstone body distribution and interlayer development. A geological profile is established along the well trajectory to determine the location of the horizontal well trajectory. Finally, trajectory optimization is performed. This steering method effectively combines geological and seismic data, using three-dimensional geological modeling to reasonably predict the distribution of reservoir sandstone bodies and scientifically assess interlayer development. The geological steering method and its implementation effectiveness are effectively guaranteed, and it can meet the geological steering requirements of different gas reservoirs and well areas with significantly different geological characteristics.

The invention discloses an integrated computer system for immune state analysis, and belongs to the technical field of immune detection. According to the method, first sequencing data of a T cell receptor of a to-be-detected user are obtained, second sequencing data of a T cell receptor of a historical user before the current moment are obtained, a first undirected weighted graph is constructed according to the first sequencing data, and data vertexes of the first undirected weighted graph are CDR3 clone types of the first sequencing data and CDR3 clone types of the second sequencing data. The data edge of the first undirected weighted graph is the similarity of a CDR3 clone type, and the CDR3 clone type is a unique CDR3 beta amino acid sequence clone type, determining a first analysis feature according to a graph clustering algorithm and the first undirected weighted graph, and determining the immune state of the to-be-detected user according to the first analysis feature and the second analysis feature corresponding to the second sequencing data. The method has the beneficial effect of improving the accuracy of immune state analysis.

The invention discloses a preparation method of a ZnO window layer film with Mo as a buffer layer, and belongs to the technical field of film preparation. The method sequentially comprises the steps of substrate pretreatment, Mo buffer layer magnetron sputtering deposition, ZnO window layer radio frequency magnetron sputtering deposition and annealing post-treatment. Through precise regulation and control of process parameters, lattice transition matching is realized by means of characteristics of Mo and ZnO. The method effectively solves the problems of weak binding force between the ZnO film and the substrate, poor crystallization quality, high defect density, high energy consumption and the like in the prior art, is high in process compatibility and controllable in parameter, is suitable for large-scale preparation of the high-performance ZnO film, and can be widely applied to the photoelectron fields of solar cells, display devices and the like.

The present invention provides a lipid nanoparticle including an ionic lipid represented by the following formula (1) wherein the symbols are as defined in the specification and an activated PEG lipid-bonded ligand having cell directivity.

The application relates to the technical field of biomedical materials, and specifically discloses a preparation method of a double-crosslinked 3D-printed bone repair scaffold. The scaffold is made of a biphasic calcium phosphate matrix and a gelatin methacrylate hydrogel outer layer. The preparation method comprises the following steps: firstly, preparing biphasic calcium phosphate ink, and constructing a porous scaffold blank through 3D printing; then, carrying out double-crosslinking treatment of calcium chloride solution and glutaraldehyde solution in sequence to obtain a scaffold matrix with enhanced mechanical properties; then, preparing gelatin methacrylate hydrogel loaded with modified teriparatide, and compounding the gelatin methacrylate hydrogel with the scaffold matrix; and finally, obtaining the final product after blue light crosslinking and solidification. The bone repair scaffold has good biocompatibility and osteogenic activity, and can effectively promote bone defect repair. In addition, the preparation method is controllable and has good repeatability, the structure of the scaffold is accurately controlled through the 3D printing technology, and a new approach is provided for the preparation of personalized bone repair materials.

The invention discloses a single-domain antibody specifically combined with a Gn protein of a severe fever with thrombocytopenia syndrome virus. Experiments prove that the antibody has strong binding activity to the Gn protein of the severe fever with thrombocytopenia syndrome virus, the neutralizing effect of pseudovirus and live virus is obvious, and the purity is high after the antibody is humanized. The invention can be used for preparing drugs for treating or preventing diseases caused by severe fever with thrombocytopenia syndrome virus infection, and provides a new means for prevention and control of related diseases.

The utility model relates to a screw reagent bottle for an in-vitro diagnostic reagent. The screw reagent bottle comprises a bottle body and a bottle cap, the bottle body is made of glass, the bottle opening is a threaded opening, and the bottle bottom is provided with a micro-groove. The bottle cap is made of plastic and is provided with a first end face, a second end face and a third end face, anti-skid stripes are regularly arranged on the outer side of the first end face, threads are arranged on the inner side of the first end face, the first end face and the second end face are in a concentric circle shape, the second end face is an annular protrusion, the third end face is in a plane shape, and a sealing ring is arranged between the first end face and the second end face. The in-vitro diagnostic reagent storage and transportation device is simple in structure, improves sealing performance by optimizing structural design, is suitable for storage and transportation of in-vitro diagnostic reagents, and has the adaptation capacity of automatic equipment and the operation stability of reagent bottles.

The application provides a binding protein specifically binding to Mycoplasma pneumoniae P1 protein, a preparation method and application, and relates to the technical field of biotechnology.The binding protein contains a heavy chain variable region and a light chain variable region, the complementarity determining region of the heavy chain variable region includes an amino acid sequence identical to VH-CDR1, VH-CDR2 and VH-CDR3 of the heavy chain variable region shown in SEQ ID NO.1; the complementarity determining region of the light chain variable region includes an amino acid sequence identical to VL-CDR1, VL-CDR2 and VL-CDR3 of the light chain variable region shown in SEQ ID NO.2 or 3.The binding protein has good specific binding capacity to the Mycoplasma pneumoniae P1 protein, can also bind to Mycoplasma pneumoniae whole bacteria, and can be used for detection of Mycoplasma pneumoniae or Mycoplasma pneumoniae P1 protein, and detection and diagnosis of Mycoplasma pneumoniae or Mycoplasma pneumoniae infection.

The invention provides a method for automatically generating an oral image report, which comprises the following steps of: receiving and processing oral medical image data; classifying the processed oral medical image data, and performing matching based on the classification result and pre-stored oral illness state text data; wherein the oral disease condition text data comprises a disease description text and a diagnosis suggestion text; correlating corresponding image information and text information based on the matching result, and generating a standardized diagnosis report corresponding to the oral medical image; detecting and correcting potential errors in the standardized diagnosis report according to expert knowledge base data, and generating a target report; wherein the expert knowledge base data comprises morphological characteristics of an anatomical structure, disease characteristics and diagnosis suggestions. According to the invention, the standardization level of oral medical diagnosis is improved, the report is more intuitive, and the workload of doctors is reduced.

The application provides a far-infrared light quantum flexible sensing fabric and a weaving method thereof, which comprises a far-infrared light quantum heating area and a flexible sensing area. The heating area is interwoven by warp yarn and weft yarn, the warp yarn comprises an electrode wire and common yarn, and the weft yarn comprises conductive heating yarn and common yarn I. The flexible sensing area is interwoven by warp yarn and weft yarn, the warp yarn of the flexible sensing area is consistent with that of the heating area, and the weft yarn comprises conductive sensing yarn and common yarn II. The flexible sensing area selects yarn with better conductivity and resilience, after pressure action, the conductive yarn is deformed, the conductive yarns in different layers are in contact, the corresponding resistance changes, after the pressure is removed, the sensing area fabric is easier to recover the deformation, the resistance returns to the value before the pressure action, the sensing strain and pressure are obvious, so that the flexible sensing fabric has the advantages of short effective response time, high sensitivity and good response stability.

The invention discloses an energy storage scheduling optimization system, method and device for a power distribution network and a medium, and belongs to the technical field of power system energy storage scheduling, and the system comprises a data collection module which is used for monitoring the power distribution network, obtaining monitoring index data, and transmitting the monitoring index data to a cloud management platform; the scheduling strategy making module is used for analyzing the monitoring index data according to the management platform, obtaining a calculation result and making a scheduling strategy according to the calculation result; the instruction execution module is used for controlling the user side equipment to perform charging and discharging operation according to the scheduling strategy; and the closed-loop feedback module is used for monitoring the power distribution network after the charging and discharging operation is executed, acquiring feedback data and adjusting a scheduling strategy according to the feedback data. According to the invention, the problems of fragmentation of data acquisition and insufficient adaptability of a scheduling strategy and an actual operation state of a power distribution network energy storage scheduling system are solved.

The present invention relates to a bearing-type bush for mounting an anti-roll bar of an automobile or a mechanical device, and more particularly, to a bush for supporting an anti-roll bar, which is installed in an automobile or various mechanical devices, and which has an effect of bearing a torsional load while keeping left-right balance to prevent rolling, and more specifically, to a bush for supporting an anti-roll bar, which is installed in an automobile or various mechanical devices, and to minimize rubber molding, and to improve the durability of the anti-roll bar. According to the present invention, light weight is achieved by replacing a plastic member as much as possible, a strong supporting force can be obtained, and particularly, the load in the R direction can be minimized, and the resistance in the Q direction can be enhanced.

The application discloses a video stabilization method and system based on video inter-frame homography transformation, belongs to the technical field of video supervision, and effectively distinguifies foreground and background in a video through a foreground mask module; after the foreground part is covered by using the mask, effective shallow semantic features of a background area are acquired through a credible shallow feature extraction module; for the effective shallow features of the background area, a motion estimation module associated with local features and global features is used to estimate the homography relationship between continuous adjacent frames; through a video stabilization smoothing module, the homography between the transformation frame and the reference frame obtained by using the motion relationship between adjacent frames is used to realize the stabilization of the whole video by using STN transformation. The effective combination of the foreground mask and the credible shallow feature avoids the artifact or distortion phenomenon caused by large disparity, the local and global feature relationship is established based on the credible shallow feature, accurate camera motion is obtained, and finally, the video stabilization is realized.

This invention provides a nanobody targeting carp herpesvirus type II and its application. The amino acid sequence of the nanobody is shown in SEQ ID NO. 1-6. The method includes immunizing alpacas with inactivated carp herpesvirus type II, collecting peripheral blood from the immunized alpacas and separating lymphocytes, and extracting total RNA; synthesizing cDNA by reverse transcription, and amplifying the gene fragment encoding the nanobody; ligating it into the pComb3xss vector, and then transforming it into competent cells to construct a nanobody phage display library; enriching and panning the inactivated virus as a coating antigen to obtain specifically binding phage particles; transforming the selected positive clones into host bacteria for induced expression; and obtaining the anti-carp herpesvirus type II nanobody after separation and purification. This invention aims to provide a carp herpesvirus type II nanobody that is low in expression cost and difficulty, has a stable source, can effectively bind to carp herpesvirus type II, and specifically achieves immunoassay of carp herpesvirus type II.

The invention relates to a radiator assembly for a vehicle, having a radiator with at least one radiator body, the radiator body having at least two coolant channels extending spaced apart from one another and a plurality of ribs extending between the at least two coolant channels, wherein a gap for the flow of cooling air is formed between each two ribs of the plurality of ribs, the radiator assembly further having a radiator fan module comprising at least one fan wheel for influencing a flow of cooling air in the direction of the radiator body, on the radiator body the plurality of ribs extending between the two coolant channels is divided into at least two different radiator regions, wherein, in an observation direction along the direction from the radiator fan module towards the radiator body, the radiator fan module at least partially covers a first radiator region of the at least two different radiator regions and, in comparison with a second radiator region of the at least two different radiator regions, in the first radiator region a gap width of the gap present between the two ribs is greater.

The application relates to a fine path loss prediction method of a bimodal network correction, and belongs to the technical field of wireless communication.The method is used for solving the problem that an existing method cannot balance the complexity and accuracy of path loss prediction, the method gives a statistical prediction value by using a path loss empirical model, completes common characterization of path loss, then a bimodal network is used to learn specific propagation characteristics of a communication environment from two modes of vision and features, a correction value of the path loss empirical model is obtained, and specific description of path loss at different positions is completed.The application is applied to the field of wireless communication, combines artificial intelligence and statistical methods, and can realize fine modeling of path loss.

The application belongs to the technical field of spraying equipment, and particularly relates to a metal structure corrosion-resistant spraying device for a hydropower plant, which comprises a spraying device, wherein the spraying device comprises a bottom plate, a fixed base is arranged on the bottom plate, a movable base is slidably arranged on the opposite side of the fixed base, first side plates and second side plates are respectively arranged on the two sides of the fixed base and the movable base, first lead screws are arranged on the opposite sides of the fixed base and the movable base, the two first lead screws are rotatably arranged on a vertical plate and driven by a first motor, driving blocks are spirally arranged on the two first lead screws, a sliding rod and a second lead screw are rotatably arranged on the two driving blocks, two U-shaped plates are spirally arranged on the second lead screw, the sliding rod is slidably connected with the two U-shaped plates, and spraying mechanisms are arranged on the bottoms of the two U-shaped plates. The spraying mechanisms can avoid the formation of an isolation layer and the advance travel of a dry paint film, thereby preventing the adhesion of a coating from being reduced.

The utility model discloses an overlapped assembly type concrete anti-collision guardrail, and belongs to the field of road and bridge engineering. The guardrail is composed of two oppositely-arranged prefabricated anti-collision guardrail panels, a main beam bridge deck and the like, various steel bars are pre-embedded in the prefabricated panels, angle steel is pre-embedded on the outer side of the bottom and connected through snake-shaped connecting steel bars, vertical and bottom side stress main bars are welded to the angle steel, the angle steel is welded to a pre-embedded steel plate of the main beam bridge deck, and stiffening ribs are arranged. Compensation shrinkage concrete is poured in gaps between the panels, and reserved pipelines, waterproof steel bar reserved holes and rabbets are further arranged. According to the guardrail, a traditional formwork is replaced by the standardized prefabricated panel, the problems that the formwork is complex to install and prone to slurry leakage are solved, and standardized production of the prefabricated panel is achieved; rigid is enhanced through a reasonable connecting structure, all parts form a whole, meanwhile, it is guaranteed that new concrete and old concrete are tightly combined, water seepage is prevented, the construction efficiency and using performance of the bridge anti-collision guardrail are effectively improved, and the requirement for modern bridge industrial construction is met.