2589 results about "Self-assembly" patented technology

The invention belongs to the technical field of perovskite solar cells, and particularly discloses a carbazolyl conjugate enhanced self-assembled monomolecular layer and a preparation method and application thereof, and the self-assembled monomolecular layer takes carbazole as a substrate and an aromatic ring as a conjugate linking group. The highly conjugated molecular system can induce molecular orbital overlap, increase dipole moment, promote formation of a compact self-assembled monomolecular film, reduce interface non-radiative recombination and enhance hole extraction and transmission performance. Meanwhile, phosphoric acid is used as an anchoring group, so that firm self-assembly of SAM molecules on the surface of the ITO substrate can be realized. The SAM material is simple in preparation method, high in yield, low in preparation cost and good in stability. When the compound is applied to a trans-perovskite solar cell as a hole transport layer, photoelectric conversion efficiency exceeding 24.6% can be obtained, and the compound is an organic semiconductor material with a very good prospect.

The invention belongs to the technical field of perovskite solar cells, and particularly discloses a self-assembly monomolecular film hole transport material based on diphosphoric acid and a preparation method and application thereof.The diphosphoric acid serves as an anchoring group, the chelation between the material and a conductive base can be effectively enhanced, the self-assembly characteristic of the material on the surface of a substrate is improved, and the hole transport efficiency is improved. The compact and smooth self-assembled monomolecular film is formed. Meanwhile, the electron and space effects of alkyl chains or benzene ring connecting units are regulated and controlled, so that the molecular stereo configuration and energy level matching are optimized. The material disclosed by the invention is simple in synthesis steps and low in preparation cost, and industrial synthesis of the material can be realized. When the material is applied to an inverted perovskite solar cell as a hole transport layer, photoelectric conversion efficiency exceeding 24.7% and excellent device stability performance can be obtained, and huge commercial prospects are shown.

The invention relates to a preparation method of a self-assembled monomolecular layer in a perovskite cell, and belongs to the technical field of solar cells, and the preparation method comprises the following steps: S1, preparing an SAM layer; step S1.1, soaking the conductive glass substrate into the preheated SAM first precursor solution; step S1.2, quickly soaking in a second SAM precursor solution; s1.3, taking out and removing the residual solvent to obtain an SAM layer; step S2, annealing; s3, preparing a perovskite light absorption layer and other functional layers; and depositing a perovskite light absorption layer and other functional layers on the SAM layer in sequence, and finally preparing a complete perovskite solar cell. According to the method, the appropriate high-boiling-point solvent is selected to prepare the SAM precursor solution, then the conductive substrate is rapidly soaked in the SAM precursor solution under the condition that the high temperature is kept, SAM molecules are rapidly self-assembled within seconds at the high temperature, the self-assembled molecular layer is more uniform and compact, the perovskite buried bottom interface has fewer defects, the interface contact is better, and the performance of the conductive substrate is improved. And the efficiency and the stability of the perovskite cell are obviously improved.

The present invention discloses a self-assembled monolayer hole transport material based on an alkyl polyphosphate anchoring group, a synthesis method thereof, and an application in an inverted perovskite solar cell. The present invention uses carbazole or 3,6-diphenylcarbazole with good hole transport properties as a parent core, and achieves complete coverage and stable self-assembly of the material on the substrate surface by improving the anchoring group from traditional alkyl monophosphate to alkyl diphosphate and triphosphate. The synthesis method of the present invention is simple and the synthesis cost is low. The prepared material can achieve the dual functions of hole transport and perovskite interface passivation, while enhancing the self-assembly strength and stability. When the material is used as a hole transport layer in an inverted perovskite solar cell, a photoelectric conversion efficiency of >20% can be obtained without doping, and the material has broad application prospects.

The invention discloses a thiapyran molecule modified solar cell and a preparation method thereof. The cell sequentially comprises an ITO (Indium Tin Oxide) conductive glass layer, a 4-aminotetrahydro-2H-thiapyran-1, 1-dioxide hydrochloride modified [4-(3, 6-dimethoxy-9H-carbazole-9-yl) butyl] phosphonic acid hole transport layer, a Cs0.05 (FA < 0.77 > MA < 0.23 >) < 0.95 > Pb < (I < 0.77 > Br < 0.23 >) 3 wide-band gap perovskite thin film, a phenethyl ammonium iodide passivation layer, an electron transport layer of [6, 6]-phenyl-C61-butyric acid isomethyl ester, a 2, 9-dimethyl-4, 6, 7-tetrahydro-2H-thiapyran-1, 1-dioxide hydrochloride modified [4-(3, 6-dimethoxy-9H-carbazole-9-yl) butyl] the hole barrier layer is made of 1, 7-biphenyl-1, 10-phenanthroline; the electrode layer is made of metal Ag; according to the scheme, the hole transport layer is modified through thiapyran molecules, agglomeration of the hole transport layer is relieved, and a more compact and more uniform self-assembled single layer is generated by inducing favorable crystal orientation. A good bottom interface is obtained based on thiapyran molecule modification, and ordered growth of high-quality perovskite crystal grains is promoted. In addition, the energy level of the hole transport layer is effectively adjusted through thiapyran molecule treatment, and the extraction and transmission of carriers by the hole transport layer are enhanced.

This invention discloses a fluorene-based organic small molecule hole transport material and its applications. The general structural formula of the fluorene-based organic small molecule hole transport material is as follows: where n = 1-4, and R represents the hole transport capacity. This fluorene-based organic small molecule hole transport material is used as an undoped hole transport material in perovskite solar cell devices. By introducing dicarboxylic acid groups onto the fluorene-based organic small molecule hole transport material, when used in an inverted perovskite solar cell device, it can form chemical bonds with the hydroxyl groups of the glass conductive substrate, forming a directionally aligned self-assembled layer on the surface of the glass conductive substrate. This effectively improves the charge transport capability at the interface and increases the photoelectric conversion efficiency of the perovskite solar cell device. Furthermore, since this perovskite solar cell device does not contain lithium salts, it exhibits high water and oxygen stability. In addition, the synthesis process of this fluorene-based organic small molecule hole transport material is simple, and the raw materials are inexpensive and readily available, making it highly valuable for practical applications.

Embodiments of improved methods are provided to form ordered structures on a surface of a substrate using direct self-assembly (DSA) of ionic liquid crystals (ILCs). More specifically, various embodiments of methods are provided to control the pitch of a layered structure formed on a substrate surface via self-assembly of ILCs having cation head groups, alkyl tail groups and anions. In the embodiments disclosed herein, the pitch of the layered structure is controlled by: (a) controlling the cation / anion charge ratio of the cation head groups and anions included within the ILCs, and / or (b) adding an ionic liquid to a solution comprising the ILCs.

The invention relates to the technical field of solar cells, and mainly provides a perovskite solar cell and a preparation method thereof. The perovskite solar cell comprises a substrate, a transparent conductive oxide layer, an anchoring layer, a hole transport layer, a perovskite light absorption layer, an electron transport layer and a top electrode which are stacked in sequence, wherein the material of the anchoring layer comprises a metal oxide; and the material of the hole transport layer comprises a self-assembly molecular material. According to the perovskite solar cell in the technical scheme of the invention, the anchoring point of the SAM is enhanced, the long-term stability of the perovskite cell is improved, and the efficiency loss caused by local electric leakage is reduced.

The invention discloses a self-assembly material, a solar cell and electric equipment, the self-assembly material comprises a first self-assembly molecular material, the structural formula of the first self-assembly molecular material is # imgabs0 #, Ar represents an aryl group, the Ar comprises at least one coordination atom, the coordination atom comprises lone pair electrons which are not bonded, and the first self-assembly molecular material comprises a second self-assembly molecular material, a third self-assembly molecular material and a fourth self-assembly molecular material, the coordination atoms comprise one or more of phosphorus atoms, arsenic atoms, sulfur atoms and selenium atoms; l comprises one or more of a carbon-containing group, a nitrogen-containing group, an oxygen-containing group, a silicon-containing group, a phosphorus-containing group and a sulfur-containing group, and n is 0-10; a comprises a hydrophilic group. When the self-assembly material is used for passivating the light absorption layer of the solar cell, a better passivation effect can be realized, and the photoelectric conversion efficiency and the stability of the solar cell can be improved.

The invention provides a layer-by-layer self-assembled nanofiltration membrane and a preparation method and application thereof.The layer-by-layer self-assembled nanofiltration membrane comprises a base membrane and a self-assembled coating formed on the base membrane, and the self-assembled coating at least comprises an initial alternating coating and a separation alternating coating; the molecular weight cutoff of the base membrane is not less than 500kDa; the initial alternate coating is formed by alternately assembling a large-molecular-weight cationic polyelectrolyte layer and an anionic polyelectrolyte layer, and the separation alternate coating is formed by alternately assembling a small-molecular-weight cationic polyelectrolyte layer and an anionic polyelectrolyte layer; the initial alternating coating is formed on the base membrane, and a high-molecular-weight cationic polyelectrolyte layer in the initial alternating coating adopts cationic polyelectrolyte with the number-average molecular weight not less than 500kDa; and the small-molecular-weight cationic polyelectrolyte layer in the separation alternate coating is cationic polyelectrolyte with the number-average molecular weight not exceeding 100kDa. The layer-by-layer self-assembled nanofiltration membrane provided by the invention has more excellent permeability and micropollutant rejection rate.

The invention relates to the technical field of soil conditioners, and particularly discloses an intelligent controlled-release core-shell alginate soil conditioner and a preparation method thereof.The conditioner is of a core-shell-layer three-layer structure and comprises a core layer, a middle shell layer and an outer layer, the three layers account for 30%, 40% and 30% of the total weight respectively, and the core layer mainly comprises improved alginate and nutrients; the middle shell layer mainly comprises chitosan and a microbial preparation; and the outer layer mainly comprises modified charcoal and magnetic nano # imgabs0 #. The preparation method comprises the four steps of core layer preparation, middle shell layer coating, outer layer coating and forming post-treatment, and multiple functions of accurate nutrient supply, efficient heavy metal fixation and soil microenvironment regulation and control are achieved through a core-shell-layer three-layer structure design and a pH / temperature / microorganism triple response mechanism by adopting a coaxial electronic injection and layer-by-layer self-assembly technology; the fertilizer has a remarkable improvement effect on sandy soil and saline-alkali soil, and the organic matter increasing rate reaches 40%.

The invention relates to the technical field of electronic elements, in particular to a ternary compound for a memristor array and a preparation method of the ternary compound. The ternary complex comprises A, B and C, A is a guest molecule of a pyridine derivative with an amino terminal, B is a bridging molecule, and C is a host molecule with a cucurbituril structure. A, B and C are self-assembled in an aqueous solution through Van der Waals force and hydrophobic interaction among molecules to form a ternary complex; the host molecule C has a barrel-shaped cavity structure, and the guest molecule A and the bridging molecule B are included in the barrel-shaped cavity structure. The ternary complex forms a supramolecular chain junction at the end part of the graphene electrode, so that the graphene electrode with different gaps can be adapted, and the molecular connection success rate of the array is greatly improved. The preparation method of the ternary complex is simple, convenient, easy to operate and suitable for large-scale production.

The invention relates to the field of ultrasonic sensors, provides an ultrasonic sensor and a preparation method thereof, an ultrasonic fingerprint module and electronic equipment, and at least facilitates improvement of the performance of the ultrasonic sensor. The preparation method comprises the following steps: forming a bottom electrode layer on a substrate; forming a piezoelectric layer on the bottom electrode layer; a top electrode is formed on the piezoelectric layer, and the top electrode layer is prepared through the steps that the surface of the piezoelectric layer is treated, so that the surface of the piezoelectric layer has hydrophilicity; carrying out silanization treatment on the piezoelectric layer to form a self-assembled molecular layer; soaking the substrate subjected to silanization treatment in a pre-polymerization solution, so that the self-assembled molecular layer and monomers in the pre-polymerization solution are polymerized to form an adhesion layer; forming a catalyst layer on the adhesion layer; the substrate with the catalyst layer is placed in a chemical plating tank, so that a catalyst in the catalyst layer catalyzes metal ions in the chemical plating tank to form a metal layer, and the adhesion layer and the metal layer form a top electrode layer; and forming a protection layer on the top electrode layer.

The present invention relates to the field of biomedical materials. Particularly provided is a DNA-silk fibroin composite hydrogel microsphere. The DNA-silk fibroin composite hydrogel microsphere is prepared from DNA and silk fibroin on the basis of the micro-fluidic technology by means of combination of self-assembly physical crosslinking and photo-crosslinking. The introduction of a silk fibroin network into the composite hydrogel microsphere can provide mechanical performance for a DNA hydrogel network and reduce the production cost. RGD can remarkably improve the cell loading capability of the microsphere. The hydrogel microsphere can simulate a microenvironment of cartilage tissue by means of three-dimensional loading of high-density cells, so as to enhance substance exchange and signaling between cells, and more effectively promote the proliferation and adhesion of bone marrow mesenchymal stem cells and regulating the chondrogenic differentiation, thus promoting cartilage regeneration and repair, and providing an available material for preparing medicaments or medical instruments for cartilage defect repair.

The invention provides an intermediate layer structure for a solar cell and a preparation method and application thereof. The intermediate layer structure comprises a transparent conductive oxide layer, a self-assembled monomolecular hole transport layer and a self-assembled monomolecular connecting layer for connecting the transparent conductive oxide layer and the self-assembled monomolecular hole transport layer, the material of the self-assembled monomolecular hole transport layer is a self-assembled monomolecular material with a phosphonic acid end group; the material of the self-assembled monomolecular connecting layer is selected from one or two of a silane self-assembled monomolecular layer material or a carboxylic acid self-assembled monomolecular layer material, and the silane self-assembled monomolecular layer material and the carboxylic acid self-assembled monomolecular layer material have sulfydryl groups; the problems that in the prior art, the material coverage rate of a self-assembled monomolecular hole transport layer on a TCO is low, and the material distribution of the self-assembled monomolecular hole transport layer is not uniform are solved.

The invention discloses an application of a microporous and mesoporous metal organic framework microsphere material in organic dye and heavy metal wastewater. According to the invention, mesoporous spheres formed by self-assembly of a block copolymer are used as objects, and regular and highly dense mesoporous micron-sized particles of a self-assembled amphiphilic block copolymer (PS-b-PAA) in a selective solvent mixture are used as a template; uiO-66-NH2 and ZIF-67 micron-sized microspheres which are formed by mutual growth of metal-organic framework nanocrystals and have two pore diameters of micropores and mesopores at the same time are produced, and larger carrying capacity is obtained, so that adsorption separation is more efficiently realized. The adsorbent is respectively used for dye adsorption and heavy metal ion adsorption, and the adsorption performance and mechanism of the adsorbent are explored. The metal organic framework microspheres with both micropores and mesopores are used as an adsorbent, and a simpler, more convenient and novel method is provided for adsorption.

The invention provides a bionic antibacterial peptide, a pharmaceutical composition, application of the bionic antibacterial peptide in preparation of antibacterial drugs and a design method of the bionic antibacterial peptide. A plurality of compounds are used for carrying out N-terminal modification on a polypeptide sequence consisting of 20 natural amino acids, so that a novel antibacterial peptide with a bionic function is generated, and the designed bionic antibacterial peptide is screened by adopting a method based on deep learning and experimental interaction. Compared with traditional drug screening, consumed time, manpower, material resources and financial resources are greatly reduced, the designed novel bionic antibacterial peptide has good biocompatibility, a functional group modified at the N end of the novel bionic antibacterial peptide can activate the self-assembly activity of polypeptide and help the polypeptide target a bacterial membrane, bacterial drug resistance is not likely to be caused, and the novel bionic antibacterial peptide has good application prospects. The drug-resistant bacteria can be effectively killed, the sterilization speed is higher, and potential and wide application prospects are achieved in clinical treatment of bacteria and drug-resistant bacteria infection diseases.

The invention discloses a preparation method and application of an ammonium ion pre-embedded Cu-MOF derived CuHCF / MXene electrode material, and relates to the technical field of new energy nanometer materials. According to the preparation method, Cu-BTC is taken as a sacrificial template, ammonium ion pre-embedding and flaky MXene compounding are carried out, and synthesis is carried out under the condition of coprecipitation at room temperature. The preparation method provided by the invention is low in cost and simple in process, and the obtained electrode material is excellent in morphology and performance. When the prepared CuHCF / MXene composite electrode is applied to capacitive deionization, the characteristic of high NH4 < + > adsorption capacity is shown. According to the preparation method, hydrogen-bond interaction is formed between H atoms in NH4 < + > and N atoms in CuHCF, so that the NH4 < + > adsorption potential energy is reduced, the adsorption capacity is improved, and meanwhile, the defects that CuHCF is prone to agglomeration, poor in conductivity and the like are overcome through self-assembly of the CuHCF and MXene.

The invention provides high-activity contact type silver powder for photovoltaic conductive silver paste, a preparation method of the high-activity contact type silver powder and the photovoltaic conductive silver paste, and belongs to the technical field of photovoltaic materials. The high-activity contact type silver powder comprises net-shaped polycrystalline spherical silver powder and an active layer wrapping the surface of the net-shaped polycrystalline spherical silver powder. Wherein the reticular polycrystalline spherical silver powder is a spherical aggregate formed by stacking and self-assembling flaky particles with the particle size of 200-600 nm, and the reticular polycrystalline spherical silver powder is of a porous structure; and the active layer is an organic amine compound. The silver powder disclosed by the invention has good conductivity after being sintered, the adhesive force of a fine grid is relatively high, and the assembly has relatively high power output.

The invention discloses a self-assembled nano material for targeting liver and improving fatty liver as well as a preparation method and application of the self-assembled nano material, and belongs to the technical field of preparation of novel nano materials. According to the invention, a self-assembled nano material is formed by MOF, thyroid hormone and an ASGR1 antibody. The MOF material has good preservation performance, can effectively remove active oxygen in cells and intercellular substances, and reduces damage of the active oxygen to liver cells. The thyroid hormone is gathered in the MOF, the thyroid hormone can be accurately released after the MOF is targeted to the liver, the effect of the thyroid hormone on relieving the fatty liver degree is efficiently achieved, and toxic and side effects of the thyroid hormone on other organs of the whole body are effectively avoided. The surface of MOF is modified with an ASGR1 antibody, the antibody can accurately target the self-assembled nano-material to the surface of a liver cell membrane, and the ASGR1 antibody can effectively inhibit ASGR1 on the surface of the liver cell membrane, so that the self-assembled nano-material can effectively promote discharge of cholesterol in cells.

The invention belongs to the photovoltaic field, and particularly relates to a self-assembled monolayer (SAMs), a perovskite solar cell and a preparation method. The self-assembled monolayer comprises a self-assembled monolayer molecule and a thiophene organic matter. The thiophene organic matter forms a frame structure after SAMs film forming, the stability of SAMs can be improved, meanwhile, the carrier transport efficiency of a hole transport layer is improved through the pi-pi conjugation effect, and the performance of a device is improved.

The invention belongs to the technical field of biomedical high-molecular polymer materials, and discloses a pH and temperature dual-response lignin-based amphiphilic polymer and micelle as well as a preparation method and an application of the pH and temperature dual-response lignin-based amphiphilic polymer and micelle. The preparation method of the polymer comprises the following steps: purifying the alkali lignin, preparing a macroinitiator AL-Br based on the alkali lignin, and then preparing the lignin-based amphiphilic polymer with double responses of pH and temperature. The polymerization process is controllable, and the usage amount of copper is lower than 500 ppm. The lignin polymer disclosed by the invention can be self-assembled into nano-scale micelles in a water medium, the structure is stable, and AgNPs and an entrapped hydrophobic anticancer drug CPT can be simultaneously prepared in situ. The obtained single nano-carrier system has good silver nanoparticle stabilizing capacity, in-vitro pH and temperature double-response drug release capacity and excellent cytotoxicity and antibacterial capacity, can achieve the anti-tumor and antibacterial purposes at the same time, and is well applied to preparation of drugs with anti-tumor and antibacterial effects at the same time.

The disclosed subject matter relates compounds of structure (I), and polymers of structure (II) having a polydispersity ranging from 1 to about 1.1, compositions comprising said polymers and a spin casting solvent, the process of forming a pinning layer selectively on metal with said composition and the process of using said pinning layers to affect chemoepitaxy directed self-assembly of an overlying block copolymer, and the subsequent process of pattern transfer of this self-assembled layer into a substrate by etching.

The present disclosure provides an alignment method and application of a cyanobiphenyl liquid crystal composite doped with an organic donor material. The organic small molecule is doped in the host cyanobiphenyl liquid crystal, and the small molecule donor / cyanobiphenyl liquid crystal mixture is directionally induced to assemble by virtue of the large surface energy difference between the superhydrophobic structured substrate and the superhydrophilic flat substrate. The liquid crystal molecules form a uniform arrangement under the action of the liquid bridge, driving the self-assembly of the small molecule donor to be embedded in the cyanobiphenyl liquid crystal, forming a structure of electron donor-donor, enhancing the conductivity of the liquid crystal composite device, studying the influence of the surface tension of the solvent on the performance of the composite, and giving a direction for the selection of the solvent. Compared with the methods of inducing the alignment of liquid crystal molecules and donor small molecules by using electric fields, magnetic fields, photolithography, capillary methods, etc., this method is simpler and more feasible, easy to transfer, the circuit pattern is easy to design, and has good stability.

The invention provides a coordination nano assembly of chiral cyclopeptide and manganese ions as well as a preparation method and application of the coordination nano assembly. According to the method, a manganese superoxide dismutase protein structural domain and a unique tumor microenvironment of melanoma high tyrosinase are combined, and polypeptide sequences L-YD-hL-DD-h, L-YL-HL-DL-H and D-yD-hD-dD-h with different chirality are designed for the first time; the chirality of the polypeptide is regulated and controlled, the in-vivo circulation stability and the cell entry efficiency of the nano assembly are improved, the coordination self-assembly of manganese and different chiral cyclopeptides is realized, and the in-situ oxidation of an in-vivo tumor microenvironment is simulated for photo-thermal therapy and cell membrane coating. The method disclosed by the invention is simple, mild in experimental condition and easy to operate, the prepared cell membrane coated nano assembly not only has long circulation stability and high cell entry efficiency, but also can realize mild photo-thermal therapy through in-situ oxidation, releases manganese ions to activate a CGAS-STING pathway for immunotherapy of tumors, and has a wide application prospect. The potential application value is realized in the field of combined treatment of tumors.

The invention provides an ER targeting self-assembly AIE probe with cascade ROS / RNS generation performance, and belongs to the technical field of material chemistry, the probe is composed of four units: 1) an AIE photosensitizer OTBS used for generating ROS; 2) deriving peptide FFVLK from beta amyloid protein, and promoting the self-assembly of the peptide to form a nanofiber with a beta-sheet structure; (3) an oligomerization arginine unit RRRR which is used as an NO donor; and 4) ER targeting signal peptide KDEL to endow ER with targeting ability. Based on ER targeting and a self-assembly process, the self-assembly AIE probe is subjected to ER in-situ self-assembly in cells to form nanofibers, ROS / RNS is generated in a cascading manner under illumination, and strong ICD is induced. In addition, the tumor residence time of the photosensitizer is prolonged due to the formation of the nanofibers, and the treatment effect is further improved. The invention provides a new thought for the design of a novel light-operated II-type ICD inducer.

The invention relates to a structural design, synthesis and application of a biomass carbon dot modified poly L-cysteine-S-S-carboxylic acid amphiphilic polypeptide. The invention provides a structural design, synthesis and application of poly (L-cysteine-S-S-carboxylic acid) amphiphilic polypeptide (P-L-cys) modified by biomass carbon dots (CDs). Comprising synthesis of P-L-cys which contains hydrophobic groups, provides hydrophilic and functionalized carboxyl and provides reduction response by disulfide bonds, synthesis of CDs and CDs modified P-L-cys (CDs (at) P-L-cys), and the macroscopic performance change of the polypeptide is explored from regulation factors of a polypeptide secondary structure and a self-assembly nanostructure assembly mechanism. The P-L-cys and the CDs (at) P-L-cys prepared by the invention have functionalization, fluorescence imaging and dual-response drug release and have particle sizes suitable for drug delivery and enrichment, and the CDs also provide a photo-thermal and photodynamic synergistic treatment effect and have good application prospects in the fields of drug delivery, cancer resistance and the like.

The invention belongs to the field of solar cells, and particularly relates to a hole transport layer, a perovskite solar cell and a preparation method. The hole transport layer comprises a NiOx layer and a self-assembly molecular layer, wherein the self-assembly molecular layer comprises a self-assembly molecular material and a surfactant. The perovskite solar cell comprising the hole transport layer has the advantages of high efficiency, high stability, low production cost and simple preparation process.

The invention belongs to the field of micro-nano structures, and relates to a preparation method of a nano needle tip split ring 3D structure periodic array. According to the method, after a reflecting layer and a supporting layer are deposited on a silicon substrate, polystyrene nanospheres are self-assembled, the volume of the nanospheres is reduced through reactive ion etching, then two times of inclined magnetron sputtering are carried out, deposited precious metal is etched through a reactive ion etching machine, and the silicon substrate is obtained. And removing the nanosphere mask to obtain the 3D structure periodic array of the nanotip split ring. The method has the characteristics of simple preparation process, good uniformity, high order degree and strong repeatability, and has wide application potential in the fields of SERS (Surface Enhanced Raman Scattering), photoelectric property detection and the like.

The invention discloses an acid responsive nanoprobe as well as preparation and anti-tumor application thereof. The nanoprobe has a core-shell structure, takes a nanoparticle self-assembled by a polycation aggregation-induced emission (AIE) photosensitizer and functional nucleic acid as a core, and takes a hyaluronic acid modified metal polyphenol network as a shell. The nanoprobe utilizes the acid responsiveness and broad-spectrum absorption performance of the metal polyphenol network and the diagnosis and treatment advantages of the polycation AIE photosensitizer to realize the acid responsiveness'switch 'controllable diagnosis and treatment of the tumor nanoprobe. In a neutral environment, the fluorescence is weak, the generation of ROS is less, and the background noise signal of the nanoprobe and the toxicity of non-targeted tissues are reduced; in an acid environment, fluorescence is enhanced, the ROS yield is improved, and the treatment efficiency and the curative effect monitoring accuracy are improved. The nano diagnosis and treatment probe is ingenious in design and simple to prepare, and can realize PDT and gene therapy synergistic anti-tumor, in-situ real-time report of early tumor treatment effect and assistance in precise cancer treatment.