718 results about "Biopolymer" patented technology

The invention discloses an immunoregulation hydrogel as well as a preparation method and application thereof, and relates to the technical field of medical materials, amino-derived cationic polysaccharide, carboxyl-derived anionic polysaccharide and dopa-modified protein biopolymer materials are used as biological matrix materials, spermidine is used as a bioactive functional component, and the immunoregulation hydrogel is prepared by a one-step method. The preparation method comprises the following steps: by taking a benzaldehyde-terminated high polymer material as a cross-linking agent, forming a first layer of dynamic reversible cross-linked network structure through Schiff base reaction; then calcium ions are introduced, and the calcium ions and carboxylate radicals are complexed and cross-linked to form a second layer of static irreversible cross-linked network structure which can be used for an ESD (Electro-Static Discharge) operation. By adopting a step-by-step cross-linking mode, the first-step cross-linked single-network hydrogel has injectability, self-repairability, tissue adhesiveness and an immune regulation function, and the second-step cross-linking further ensures stable and lasting performance, so that the problems that a submucosal injection material is easy to disperse, short in lasting time and poor in stability are solved. The immunoregulation function effect of the wound repair material is poor.

The present invention describes capsule compositions consisting of crosslinked chitosan, beta-glucan or alginate, and encapsulates an environmentally compatible insecticide, especially larvicidal agents such as essential oils or essential oil components or other ingestible larvicides such as Bacillus thuringiensis which are lethal to the larvae and adults of pest insects, especially mosquito larvae.

The invention belongs to the technical field of electrolyte materials, and particularly relates to a pH response biopolymer solid electrolyte as well as a preparation method and application thereof. The pH-responsive degradable biopolymer is taken as a main raw material, and one or more functional groups such as pyridine, sulfonic acid, carboxyl, tertiary amine, phosphoric acid and the like are contained. The organic acid and the organic acid salt are selected to adjust the pH value of a medium around the electrolyte, and the contraction / stretching behavior of a molecular chain is influenced by changing the ionization degree of the electrolyte, so that an interpenetrating polymer network structure is formed. The polar functional group of the biopolymer affects the migration behavior of lithium ions under different pH conditions, so that the migration rate and migration quantity of the lithium ions are increased, and the cycle performance of the battery is improved. The electrolyte is suitable for high-performance energy storage devices such as a lithium ion battery, can effectively improve the battery performance, reduces the environmental pollution, and has relatively strong green and environment-friendly advantages.

The invention provides a fabric-reinforced electroactive nerve conduit and a preparation method and application thereof, and belongs to the field of biomedical materials.The fabric-reinforced electroactive nerve conduit comprises a nerve conduit inner layer and a nerve conduit outer layer, the nerve conduit inner layer is a woven skeleton formed by magnesium wires serving as parallel yarns and degummed silk through a three-dimensional weaving process, the pore diameter of the nerve conduit inner layer is 1.5-2 mm, and the thickness of the nerve conduit inner layer is 0.5-1 mm; the outer layer of the nerve conduit is a composite layer with a radial finger-shaped porous structure, which is formed by directionally freezing and casting a hydrogel cross-linked network formed by mixing potassium sodium niobate nanorods modified by polydopamine and a biopolymer material, and the thickness of the outer layer of the nerve conduit is 1-2mm. A three-dimensional weaving technology, a piezoelectric nano material and a biopolymer material are combined, a novel multifunctional nerve conduit is developed to repair nerve injury, a better solution is provided for nerve repair, and the fabric enhanced electric activity nerve conduit has important practical guiding significance in application of future clinical nerve injury repair.

The invention relates to the technical field of biopolymer materials, in particular to a preparation method and application of a cationic polymer gene vector with a fluorinated end group. The invention provides a cationic polymer with a fluorinated end group. The structure of the cationic polymer is shown in the specification. According to the method, a fluorinated group is introduced through a fluorinated initiator by a one-step method to initiate synthesis of various terminal group fluorinated linear polyethyleneimine F-PEI with different molecular weights, the gene transfection efficiency is improved by introduction of the fluorine group, and high-efficiency DNA transfection is realized. The gene vector can achieve an efficient transfection effect in the cell transfection process, the toxicity generated to cells in the transfection process is small, gene molecules can be effectively and safely conveyed into the cells, and the gene transfection vector has the advantages of being efficient, low in toxicity, low in price, easy to synthesize and the like. The method has the advantages of simple reaction, easily available raw materials, low preparation cost, easily controlled molecular weight, high yield and simple post-treatment, and is suitable for large-scale production. # imgabs0 #

The funeral coffin (1) for cremation comprises a plurality of boundary walls (2) made of a biopolymer material comprising: —one bottom wall (3); —a plurality of perimeter walls (4) defining, with the bottom wall (3), one internal volume (5) for the containment of one corpse; —one lid (6) intended to close the internal volume (5) at the top; wherein the biopolymer material is of a non-biodegradable type.

Talc particulate with specific physical properties having a particularly low migration factor when used as a filler in polymers is disclosed. Such talc particulates are of specific advantage as fillers in biopolymers, which are used as food contact materials (FCMs).

The invention discloses a gas separation membrane and a preparation method thereof, and belongs to the technical field of gas separation membranes. The gas separation membrane comprises a separation layer comprising a network and PTI nanosheets dispersed in the network, the network comprising at least one of a biopolymer network and a chemical polymer network; selectively, the device further comprises a supporting layer which is arranged below the separation layer and is combined with the separation layer. The preparation method of the gas separation membrane comprises the following step A or step B: step A: enabling raw materials of PTI nanosheets and networks to form a membrane on the surface of polymer hydrogel to obtain the gas separation membrane; and step B, enabling the PTI nanosheet and the network raw material to form a membrane on the surface of the material of the support layer to obtain the gas separation membrane. The gas separation membrane provided by the invention is an N2 preferential permeation membrane, and has relatively high N2 permeation rate and relatively high N2 / CO2 selectivity.

The invention discloses a multifunctional coating with a compact-porous double-layer structure on the surface of magnesium alloy and a preparation method, and belongs to the technical field of biological materials. According to the multifunctional coating, magnesium alloy serves as a substrate, a compact layer and a porous layer are sequentially stacked from the substrate to the outside, and the compact layer is composed of two-dimensional transition metal carbide / nitride, calcium silicate nanowires and a positively charged polymer. The porous layer is composed of copper-containing complex / biopolymer composite fibers, mineralized silk fibers loaded with bioactive metal ions and astragalus polysaccharide on the surface, and natural polymers. According to the multifunctional coating with the compact-porous double-layer structure prepared on the surface of the magnesium alloy, the porous layer on the surface layer has a unique porous structure, growth and proliferation of osteoblasts can be well promoted, meanwhile, the multifunctional coating has the characteristics of pressure resistance, bacteria resistance and oxidation resistance, the compact layer on the bottom layer can improve the corrosion resistance of the magnesium alloy, and the service life of the magnesium alloy is prolonged. The coating is particularly suitable for surface coating of magnesium alloy implant materials and can be used in the field of medical instruments.

Compositions and methods for filling tissue voids and defects with a self-assembling biopolymer configured to form a shape-retaining matrix are described.

Novel approaches for processing polymeric analytes, such as biopolymers, are provided herein. A method for processing a polymeric analyte may comprise coupling a monomer of the polymeric analyte to a capture moiety, cleaving the monomer from the polymeric analyte, and analyzing the cleaved monomer, e.g., using a binding agent. The methods described herein may employ the use of activating agents.

The present disclosure generally relates to compositions and methods of simultaneously making two unique biointermediates from a single lignocellulosic biomass feedstock, including a hydrophobic biohydrocarbon and a water insoluble hydrophilic cellulosic biopolymer for use in the production of renewable fuels, chemicals, and other carbon neutral materials commonly derived from petroleum and other fossil resources.

The present invention relates to methods of manufacturing beverage capsules, the method comprising: (a) providing a biopolymer film, wherein the biopolymer film comprises a layered structure comprising biopolymer layer - polyglycolide (PGA) layer - biopolymer layer; and (b) thermoforming the biopolymer film to form at least one layer of a capsule body comprising or consisting of the biopolymer film.

Method for generating a porous injectable scaffold that includes providing a liquid composition of 2 phases at a temperature below 25° C., of Newtonian behavior, where the composition comprises:a liquid dispersant phase at room temperature formed by a gelatin with a low melting point, less than 15° C., functionalized with methacryloyl or methacrylamide groups; and a photoinitiator;and a dispersed phase, of microdroplets or beads in solid state, of a gelatin solution with a melting point greater than 25° C.;initiating the polymerization of the dispersing phase by light radiation; raising the temperature to 35-40° C. and allowing melting of the dispersed phase; and obtaining a porous scaffold.The formed porous scaffold and its use as a biological support for tissue regeneration / generation; as a biological matrix as a support for cells, for cell invasion; as an acellular biological matrix, a biological matrix as a mechanical support and / or a biological matrix for active components.

A biaxially oriented cavitated PHA-rich composite film comprises a PHA-rich core layer and a first outer skin layer and a second outer skin layer. The core layer comprises a PHA resin at an amount of more than 50 wt % of a total weight of the polymeric resin in the core layer and a modifier X, the modifier X includes PLA resins and PLA copolymers and at least one mineral inorganic cavitating agent; the first outer skin layer comprises a PLA resin at an amount less than 50 wt % of the total weight of the outer layer and biopolymers comprising PHA resins or PBSA resins or PCL resins or mixture thereof. The PHA-rich composite film shows a reduced film density and higher yield as well as low light transmission rate.

The invention relates to a microneedle patch, a preparation method thereof and a blood glucose colorimetric detection method, and belongs to the technical field of biomedicine. The microneedle patch comprises a needle tip layer and a backing layer, the needle tip layer is a methacrylated natural biopolymer matrix in which immobilized enzyme is uniformly distributed, and the backing layer is a methacrylated natural biopolymer matrix in which a chromogenic substrate is uniformly distributed, the immobilized enzyme is composed of a zinc-based imidazoline metal organic framework MAF-7 carrier and a natural enzyme loaded in the framework. The immobilized enzyme with double-enzyme activity is loaded into the needle tip, the spatial distance of the cascade catalytic reaction is limited in the metal organic framework, the mass transfer efficiency is high, the reaction is rapid, the natural enzyme is encapsulated in the metal organic framework MAF-7, and the stability of the enzyme is enhanced; according to the method, color development is carried out by firstly extracting the interstitial fluid and then dropwise adding the color development substrate, the color development effect is obvious, and the time is shorter.

The invention discloses terahertz regulation and control conductive aerogel and a preparation method and application thereof.The preparation method comprises the following steps that mixed precursor dispersion liquid of cellulose nanofibers, sodium alginate and conductive filler is prepared; the mixed precursor dispersion liquid is poured into a mold, the mold is immersed into liquid nitrogen, temperature gradients in the vertical direction and the horizontal direction are formed in the mixed precursor dispersion liquid, bidirectional freezing is carried out, and growth of layered ice crystals in the parallel direction in the mixed precursor dispersion liquid is promoted; after bidirectional freezing is completed, freeze drying is conducted, and the product is obtained. The layered and high-porosity aerogel is assembled through a simple and convenient two-way freeze drying process, and the biopolymer aerogel has large-scale and parallel-oriented micron-sized pores and shows excellent mechanical strength, flexibility and elasticity. The conductivity of the aerogel can be changed by compressing the aerogel, so that the terahertz performance, including birefringence and absorption characteristics, of the aerogel can be intelligently regulated and controlled.

The invention discloses degradable slope protection vegetation geotextile and a preparation method. The degradable slope protection vegetation geotextile comprises two layers of double-sided degradable biological geotextile and concrete arranged between the two layers of double-sided degradable biological geotextile; the double-sided degradable biological geotechnical cloth comprises two layers of polylactic acid biopolymer geotechnical cloth and jute fiber bundles, and the jute fiber bundles penetrate through the two layers of polylactic acid biopolymer geotechnical cloth from top to bottom and are bound to form the double-sided degradable biological geotechnical cloth. The double-sided degradable biological geotextile forms a carrier, a better growth environment is provided for plants in the biochar vegetation concrete, the blended biochar vegetation concrete is uniformly poured in the middle of the double-sided degradable geotextile, and the purpose of uniformly reinforcing the side slope is achieved.

Provided is a dry eye therapeutic agent that can selectively inhibit IFN-y, have no risk of biological contamination, and can be stored at room temperature. Provided is a dry eye therapeutic agent, comprising as an active ingredient a DNA oligonucleotide having a nucleotide sequence set forth in any of SEQ ID NO:1 to 3 and selectively binding to IFN-y. A base, X, in the sequence of the DNA oligonucleotide having the nucleotide sequence set forth in SEQ ID NO: 3 is an artificially produced base, and the artificially produced base may be chemically modified with a low-molecular-weight compound, a medium-molecular-weight compound, a large-molecular-weight compound, a biopolymer, or a biocompatible polymer.

The invention belongs to the technical field of biomedical materials, and provides a preparation method and application of hyaluronic acid microspheres with a beautifying effect, an aqueous solution dissolved with hyaluronic acid and a cross-linking agent is used as an aqueous phase, an organic solvent solution of a polyester biopolymer material is used as an oil phase, a medical microsphere preparation system is constructed, and the hyaluronic acid microspheres with the beautifying effect are prepared. The preparation method has the advantages that the reaction conditions are mild and controllable, the situation that the dosage of the cross-linking agent is reduced due to leakage of the cross-linking agent in a water phase can be effectively prevented, and meanwhile, the microspheres can be effectively prevented from being adhered or cross-linked and mixed, so that the crosslinking degree of the microspheres is uniform, and the obtained microspheres have higher mechanical strength, good elasticity and excellent enzymolysis resistance, can be maintained in vivo for a longer time, and can be used for preparing the microspheres. Wide application prospects and market values are realized in the fields of drug-loaded microspheres and cosmetic filling.

A tissue graft for soft tissue repair or reconstruction comprising a sheet of a biopolymer-based matrix having a plurality of small perforations and a plurality of large perforations. The small perforations are sized to facilitate clotting and granulation tissue development within the perforations which, in turn, facilitates revascularization and cell repopulation in the patient. The large perforations are sized to reduce the occurrence of clotting and granulation tissue development within the perforations so that extravascular tissue fluids accumulating at the implant site can drain through the tissue graft. The large perforations enhance mammal tissue anchoring by permitting mammal tissue to compress into the perforations increasing mammal tissue contact area.

The invention belongs to the field of microbial fermentation and biopolymer modification, and particularly relates to a preparation method of cross-linked polyglutamic acid and application of the cross-linked polyglutamic acid in microalgae harvesting. The preparation method comprises the following steps: by taking polyglutamic acid fermentation liquor subjected to sterilization, salting-out and redissolving treatment or a solution prepared from polyglutamic acid powder as a raw material, adjusting the pH value to be within a proper range, adding ethanol into the polyglutamic acid fermentation liquor or the solution prepared from the polyglutamic acid powder in proportion, uniformly stirring, collecting pasty precipitate, and weighing; and adding a cross-linking agent into the paste precipitate according to a proper mass ratio of the cross-linking agent to the polyglutamic acid, uniformly mixing, spreading in a drying tray, drying in vacuum drying equipment at a certain temperature to constant weight, crushing by using a crusher, and sieving by using a 40-mesh sieve to obtain a cross-linked polyglutamic acid product. The invention provides another preparation method of the cross-linked polyglutamic acid, the cross-linking reaction and the drying process are fused, the ethanol is used as an accelerant of the reaction, the dosage of the cross-linking agent is small, the product yield is high, the preparation cost is low, and the preparation method is suitable for large-scale production.

Methods of making bioactive compound-loaded nanoparticles are provided. The methods harness naturally-occurring biopolymers to produce nanoparticles from raw plant materials. Methods include contacting plant-derived materials with alkaline solution with agitation to deprotonate the bioactive materials and biopolymers to form nanoparticles. In some forms, the methods contact the nanoparticle with an acid to re-protonate the components and more stable nanoparticles. The bioactive compounds can be extracted from raw plants and / or plant parts, including turmeric, ginger, clove, thyme, pepper, and rosemary. The bioactive compounds include curcumin, gingerols, shogaols, eugenol, thymol, carvacrol, capsaicin, and rosmarinic acid. Compositions and formulations containing bioactive-compound loaded nanoparticles are also provided.

Provided is a Hunner-type interstitial cystitis therapeutic agent that can selectively inhibit IFN-γ without risk of biological contamination and can be stored at room temperature. Provided is a Hunner-type interstitial cystitis therapeutic agent or a reagent for test and research, comprising as an active ingredient a DNA oligonucleotide having a nucleotide sequence set forth in any of SEQ ID NO:1 to 3 and selectively binding to IFN-γ. A base, X, in the sequence of the DNA oligonucleotide having the nucleotide sequence set forth in SEQ ID NO: 3 is an artificially produced base, and the artificially produced base may be chemically modified with a low-molecular-weight compound, a medium-molecular-weight compound, a high-molecular-weight compound, a biopolymer, or a biocompatible polymer.

The invention relates to the technical field of biopolymer materials, in particular to temperature-resistant and salt-resistant welan gum based on cationic-hydrophobic synergistic modification as well as a preparation method and application of the temperature-resistant and salt-resistant welan gum. The preparation method comprises the following steps: dissolving welan gum powder in a system containing NaOH and DMSO, adding 3-chloro-2-hydroxypropyl trimethyl ammonium chloride and 1-bromohexadecane, adding ethanol, centrifuging to obtain a reaction solution, and finally centrifuging and freeze-drying the solid to obtain the welan gum. The salt-resistant and temperature-resistant tackifier can be used in oilfield exploitation, realizes dynamic salt-resistant and temperature-resistant tackifying in an extreme salt temperature environment, has higher viscosity, can maintain stable viscosity along with the increase of salt concentration, and is suitable for tertiary oil recovery of a high-salt stratum; the compound can be used as a seed coating agent, a soil conditioner, a pesticide slow-release carrier and a fertilizer synergist in agriculture; the product can be used as a thickening agent, a stabilizing agent and a gelling agent in the food industry; the product can be used as a humectant and a rheology modifier in the cosmetic industry; the product can be used as a cement additive in the field of building materials, and can be used in tile glue and putty powder.

The invention relates to a three-dimensional printing composition comprising a dECM hydrogel-based biomaterial, a hydrogel made of methacrylated PBS biopolymer derivatives with a radical polymerisation photoinitiator, a methacrylated chitosan solution in 1% acetic acid, neutralised to a final concentration of 3.1 mg / ml in the biomaterial, and / or a chitosan solution in 2% acetic acid, neutralised to a final concentration of 1.4 mg / ml in the biomaterial.

The invention belongs to the field of biological materials, and particularly relates to hydroxyapatite nanofiber / biopolymer composite hemostatic sponge capable of rapidly absorbing liquid and expanding as well as a preparation method and application of the hydroxyapatite nanofiber / biopolymer composite hemostatic sponge. The hemostatic sponge is formed by cross-linking and compounding hydroxyapatite nanofibers and biopolymers, the chemical composition of the hydroxyapatite nanofiber is hydroxyapatite, the diameter of the hydroxyapatite nanofiber is 10-100 nm, and the length of the hydroxyapatite nanofiber is 10-500 [mu] m; the biopolymer is one or more of chitosan, carboxymethyl chitosan, hydroxypropyl chitosan, chitosan quaternary ammonium salt, chitosan hydrochloride, hyaluronic acid, alginic acid, gelatin and collagen; the hydroxyapatite nanofiber in the hemostatic sponge accounts for 10wt%-90wt% of the total mass of the sponge. The hemostatic sponge disclosed by the invention has excellent imbibition expansion capacity, relatively high imbibition expansion pressure, good erythrocyte and platelet adsorption capacity and good blood compatibility and biocompatibility.

Novel compositions are described, each comprising at least one active constituent that has a 12-carbon atom backbone as a 12-carbon chain base structure having at least a sub-terminal nitrogen and no terminal amino group. One of the active constituents is Boc-12-Ado-OH (BOA) and / or N,N-dimethyldodecylamine N-oxide (LO). Novel particle or liposomal compositions comprising at least BOA and / or LO may be prepared with an emulsifier and / or lipid and optionally a biopolymer, and may be formulated into pharmaceutically acceptable formulations and / or medicaments with or without one or more pharmaceutically acceptable carriers or excipients for utilization as an antimicrobial against one or more microbial pathogens. The novel antimicrobial compositions have broad-spectrum growth inhibitory or other destructive activity against microbial pathogens, biofilms produced by one or more pathogens, and biofilm infections.

The application provides a silk fibroin microsphere and a preparation method and application thereof, and belongs to the technical field of biopolymer microsphere preparation. The preparation method comprises the following steps: 1) adding an ionic dispersing agent into a silk fibroin solution, uniformly mixing, then adding a sphere forming agent into the solution, and obtaining a pretreated liquid after mixing; 2) performing low-temperature coagulation treatment on the pretreated liquid, and obtaining a silk fibroin microsphere solution after thawing; 3) diluting the silk fibroin microsphere solution, then performing wet heat crystallization treatment, and obtaining a high-crystallinity silk fibroin microsphere solution; and 4) performing spray drying on the high-crystallinity silk fibroin microsphere solution, and obtaining a solid silk fibroin microsphere. The silk fibroin microsphere obtained by the application has excellent biocompatibility, degradability and good mechanical properties. The silk fibroin microsphere prepared by the method of the application is regular spherical, has high crystallinity, slow degradation speed, is not easy to absorb moisture and adhere, and can be stored for a long time; and the preparation method is simple and has high yield.