The invention relates to a device and method for simultaneously measuring permeability coefficient, compressibility coefficient and porosity of rock. The device is composed of a pressure chamber, an upstream inlet, a downstream inlet, a peripheral pressure inlet, an upstream pump, a downstream pump, a peripheral pressure pump, a vacuum pump, a peripheral pressure valve, an upstream needle valve, a downstream needle valve, a vacuum needle valve, a vacuum valve, a separating valve, a vacuum gauge, an upstream pressure gauge, a downstream pressure gauge, a differential pressure gauge, a thermometer and a console. The device is reliable in principle and simple and convenient to operate, is suitable for dynamic measurement of seepage characteristic parameters and change characteristics thereofof rock under complex stress change conditions. By adopting the device, the permeability coefficient, compressibility coefficient and porosity of the rock under the stress coupling action can be simultaneously measured, experiment basis is provided for design, construction and safety evaluation of seepage associated engineering as well as qualitative and quantitative analysis of permeation changecharacteristics and rules of the rock under the complex stress change conditions, and actual engineering requirements are satisfied.