9079 results about "Permeation" patented technology

The invention provides a plastic ampoule filled with medicinal liquid, which has the functions of blocking gas, water vapor and light and preventing drug penetration, absorption and adsorption, and a preparation method thereof. The plastic ampoule 10 for filling medicinal solution of the present invention comprises a container main body 11, a fused portion 13 closing its opening 12 and a holding portion 14 connected thereto for twisting. The ampoule 10 is formed using a parison having two or more layers, at least one of which is a material selected from the group consisting of gas transmission, water vapor transmission, light transmission, drug transmission and A functional layer that prevents at least one of drug absorption and adsorption properties. That is, the parison is extruded from a multi-layer blow mold, clamped by the lower parting die to form the main body part 11 of the container, and after filling the liquid medicine 15 therein, the opening part 12 is clamped by the upper parting die to form a fusion joint. Part 13 and holding part 14, thereby making the product of the present invention.

A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.

The present invention provides: a novel water-absorbing agent, which exhibits an excellent absorption capacity under a load (AAP), gel layer liquid permeation rate under a load (FRUP), saline flow conductivity (SFC), and shape-maintaining property and ball burst strength (BBS) of a swollen water-absorbing agent aggregate, and excellent persistency of these effects for a long time. The water-absorbing agent, which comprises a polymer obtained by a process including the steps of polymerizing and then crosslinking a monomer including acrylic acid and / or a salt thereof, with the water-absorbing agent being characterized by: (1) exhibiting a free swelling capacity of not less than 23 g / g (GV), a gel deformation of not more than 12.5 cm under a short-time load (0.5 hrPT), and a gel deformation deterioration of not more than 3.5 cm under a load with the passage of time (ΔPT); (2) exhibiting a free swelling capacity of not less than 23 g / g (GV), a ball burst strength of not less than 80 gf (BBS), and a deterioration of ball burst strength of not more than 40% (DBBS); or (3) exhibiting a free swelling capacity of not less than 23 g / g (GV), an absorption capacity of not less than 20 g / g under a load of 4.9 kPa (AAP), and a gel deformation of not more than 12.5 cm under a load (16 hrPT).

Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies are provided. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate, the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, and the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.

The water absorbent resin composition and the production method thereof according to the present invention are characterized by including: water absorbent resin particles having an internal cross-linked structure obtained by polymerizing a water-soluble unsaturated monomer; a nitrogenous ketone compound (A) (containing no carboxyl group) having a structure represented by formula (1); and a bivalent and / or trivalent and / or tetravalent water-soluble metal salt, wherein a total amount of the nitrogenous ketone compound (A) and the bivalent and / or trivalent and / or tetravalent water-soluble metal salt ranges from 0.01 to 100 parts by mass with respect to 100 parts by mass of the water absorbent resin particles, thereby providing a water absorbent resin composition, having an excellent absorption capacity represented by a centrifuge retention capacity (CRC), an absorbency against pressure of 4.83 kPa (AAP) etc., having excellent liquid permeability and liquid diffusion properties, having excellent fluidity at the time of moisture absorption, having an excellent damage resistance property, effectively suppressing occurrence of dusts, hardly bringing about permeation of added metal compounds into water absorbent resin particles, hardly bringing about segregation of added metal compounds.

A lithium ion conductive solid electrolyte formed by sintering a molding product containing an inorganic powder and having a porosity of 10 vol % or less, which is obtained by preparing a molding product comprising an inorganic powder as a main ingredient and sintering the molding product after pressing and / or sintering the same while pressing, the lithium ion conductive solid electrolyte providing a solid electrolyte having high battery capacity without using a liquid electrolyte, usable stably for a long time and simple and convenient in manufacture and handling also in industrial manufacture in the application use of secondary lithium ion battery or primary lithium battery, a solid electrolyte having good charge / discharge cyclic characteristic in the application use of the secondary lithium ion battery a solid electrolyte with less water permeation and being safe when used for lithium metal-air battery in the application use of primary lithium battery, a manufacturing method of the solid electrolyte, and a secondary lithium ion battery and a primary lithium battery using the solid electrolyte.

PCT No. PCT / JP97 / 01595 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed May 13, 1997 PCT Pub. No. WO97 / 42952 PCT Pub. Date Nov. 20, 1997A tape formulation for percutaneous administration containing fentanyl which comprises fentanyl or a salt thereof, a pressure sensitive adhesive and sodium acetate, is disclosed. The salt of fentanyl is preferably fentanyl citrate. The tape formulation of the present invention is little irritation to the skin and excellent in the percutaneous permeation of fentanyl and has a high stability even after the passage of time.

A non-polymeric or biological coating applied to porous radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.

The invention belongs to the field of surface treatment, and relates to a stainless steel cleaner. The cleaner comprises a nonionic surfactant, an anionic surfactant, a complexing agent, a degreasing agent and deionized water, wherein the degreasing agent is one of amide, and a mixture of amide and hydramine. An environmentally-friendly cleaner comprising the amide or the hydramine, a composite surfactant and the like removes grease under the alkalescent condition, and has good cleaning effect due to the permeation effect of the composite surfactant on the grease and an oxide layer. The invention also relates to a stainless steel cleaning method. The stainless steel cleaner and the stainless steel cleaning method are widely applied to the treatment of various stainless steel surfaces.

A topical, medicinal spray composition is provided comprising a drug or combination of drugs in a carrier which, when sprayed on a surface, forms a film. The composition comprises at least one medicament, at least one film former and at least one vehicle. The composition of the invention may further comprise at least one permeation enhancer, at least one solubilizer, at least one plasticizer, and at least one water soluble additive. A metered dose of the composition can be sprayed on a topical site to form a stable, breathable film, preferably over a fixed surface area. A wide range of medicaments for human and veterinary use may be present that act locally or transdermally.

The present invention discloses a method and apparatus and method for achieving non-invasive measurement of analytes from human and animal blood through the skin using Raman lightwave technology. The apparatus includes a hydraulic tissue permeation unit, which controls the amount of blood in the laser tissue interaction region. Two or more spectra are obtained at different blood levels. These spectra are used to improve the measurements.

An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face. Each electrically conductively engages the skin, when the substrate is retained thereon. A power source carried on the substrate is electrically coupled between the medicament matrix and a programmed microprocessor also carried on the substrate. A substantially invariant voltage presented at an output contact of the microprocessor is applied during a predetermined therapy period across the skin between the medicament matrix and the return electrode, inducing transcutaneous migration of medicament into the skin at a substantially constant rate. A light-emitting diode carried on the substrate and coupled to the microprocessor communicates that the patch is operating.

Metal-organic framework (MOF)-polymer mixed matrix membranes (MOF-MMMs) have been prepared by dispersing high surface area MOFs (e.g. IRMOF-1) into a polymer matrix (e.g. Matrimid 5218). The MOFs allow the polymer to infiltrate the pores of the MOFs, which improves the interfacial and mechanical properties of the polymer and in turn affects permeability. Pure gas permeation tests show the incorporation of 20 wt-% of IRMOF-1 in Matrimid 5218 polyimide matrix results in 280% improvement in CO2 permeability without a loss of CO2 / CH4 selectivity compared to those of the pure Matrimid 5218 membrane. This type of MOF-MMMs has significantly improved gas separation performance with dramatically high CO2 permeability (>35 barrer) and higher than 29 CO2 / CH4 selectivity at 50° C. under 100 psig pressure, which are attractive candidates for practical gas separation applications such as CO2 removal from natural gas.

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and / or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the devices include a membrane that has an interference domain designed to reduce the permeation of one or more interferents.

An ultrasound coupling device for acoustically coupling an ultrasound transducer with a patient's body comprises a fluid chamber having an ultrasound transducer interface for placing an ultrasound transducer in contact with water within said fluid chamber. The coupling device also has a patient interface comprising a water permeable membrane. The membrane has an internal membrane surface which is in contact with the water in the water tank and an external membrane surface can be placed in contact with the patient's body. The membrane is specially designed to allow water from inside the water tank to slowly permeate or “leak” to the external membrane surface while such surface is in contact or placed in very close proximity to the patient's skin. The slow permeation rate maintains the external membrane surface wet and free of air bubbles during a procedure which can take several hours. At the same time, the slow rate of permeation does not cause any water spillage around the patient.

A transdermal drug delivery system is disclosed, which includes a polymer, a drug and an amount of a quaternary ammonium salt that is sufficient to act as a penetration enhancer. The quaternary ammonium salt may also be present in an amount sufficient to act as an irritation reducer. Further, the transdermal drug delivery system may also contain a co-enhancer, which provides a synergistic skin permeation enhancing effect when combined with the quaternary ammonium salt. A method for enhancing the transdermal delivery of a drug is also disclosed.

An assembled structure of a large-sized LED lamp includes a substrate. One surface of the substrate is provided with a plurality of LED modules. Each LED module comprises a circuit board and a plurality of LEDs fixedly connected to the circuit board. A lamp mask is locked onto the substrate to cover and protect the LED modules. A sealing material is provided between the lamp mask and the substrate to protect the permeation of liquid. Further, at the positions of the other surface of the substrate, heat-dissipating modules are provided to correspond to each LED module, respectively. The heat-dissipating modules are used to dissipate heat generated from the LEDs. A lamp cover is covered to the exterior of the heat-dissipating modules. The lamp cover is locked onto the substrate. With the modulization of each constituent element, the detachment, assembly and repair of the present invention can be much simpler and more convenient.

Provided is a novel continuous single-step method of manufacturing a multilayer sorbent polymeric membrane having superior productivity, properties and performance. At least one layer of the polymeric membrane comprises sorbent materials and a plurality of interconnecting pores. The method includes: (a) coextruding layer-forming compositions to form a multilayer coextrudate; (b) casting the coextrudate into a film; (c) extracting the film with an extractant; and (d) removing the extractant from the extracted film to form the multilayer sorbent polymeric membrane. The sorbent membrane of this disclosure can find a wide range of applications for use in filtration, separation and purification of gases and fluids, CO2 and volatile capture, structural support, vehicle emission control, energy harvesting and storage, device, protection, permeation, packaging, printing, and etc.

Provided is a novel continuous single-step method of manufacturing a multilayer sorbent polymeric membrane having superior productivity, properties and performance. At least one layer of the polymeric membrane comprises sorbent materials and a plurality of interconnecting pores. The method includes: (a) coextruding layer-forming compositions to form a multilayer coextrudate; (b) casting the coextrudate into a film; (c) extracting the film with an extractant; and (d) removing the extractant from the extracted film to form the multilayer sorbent polymeric membrane. The sorbent membrane of this disclosure can find a wide range of applications for use in filtration, separation and purification of gases and fluids, CO2 and volatile capture, structural support, vehicle emission control, energy harvesting and storage, electrolyte batteries. device, protection, permeation, packaging, printing, and etc.

The invention provides for LNA oligomers, for the treatment of a metabolic or liver disorder, wherein the LNA oligomer is administered orally in a unit dose of less than 50 mgs / kg, wherein the LNA oligomer is administered in the presence of a penetration (permeation) enhancer.

An assembled structure of a large-sized LED lamp includes a substrate. One surface of the substrate is provided with a plurality of LED modules. Each LED module comprises a circuit board and a plurality of LEDs fixedly connected to the circuit board. A lamp mask is locked onto the substrate to cover and protect the LED modules. A sealing material is provided between the lamp mask and the substrate to protect the permeation of liquid. Further, at the positions of the other surface of the substrate, heat-dissipating modules are provided to correspond to each LED module, respectively. The heat-dissipating modules are used to dissipate heat generated from the LEDs. A lamp cover is covered to the exterior of the heat-dissipating modules. The lamp cover is locked onto the substrate. With the modulization of each constituent element, the detachment, assembly and repair of the present invention can be much simpler and more convenient.

Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.

A reactor has an aerobic tank, an anoxic tank and a sealed membrane tank with conduits for circulating mixed liquor between them. Permeation starts when the mixed liquor reaches a high level and stops when the mixed liquor reaches a low level. A sensor, for detecting the mixed liquor level, may stop and start permeation. Pressure builds in the membrane tank when membrane air is on. Transmembrane pressure is also provided by gravity flow or siphon. Membrane air generates an air lift which drives the mixed liquor circulation. The total amount of air provided by an air source is divided and varied in time between the membrane aerator and the process aerator. The process aerator acts as a screening inlet to the conduit to the membrane tank. Chemical maintenance cleaning is provided by gravity flow.

A non-polymeric or biological coating applied to radially expandable medical delivery device provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The delivery device is expanded using the pressure of an inflation fluid. After expanding the delivery device to a pre-determined size and shape, the inflation fluid weeps through the porous surface of the delivery device. The coating releases the delivery device and floats on the inflation fluid until bonding to the tissue due to its affinity for the tissue. Once the coating bonds or affixes to the tissue, through an absorption mechanism by the tissue cells of the coating material, the coating and any therapeutics contained therein are delivered to the tissue. The fluid can contain a therapeutic agent, or can be otherwise biocompatible and / or inert.

The invention discloses a preparation method for a fiber reinforced carbon-silicon carbide-zirconium carbide-based (C / C-SiC-ZrC) composite material. The preparation method comprises the following steps of: (a) evenly dispersing ZrC nanopowder in absolute ethyl alcohol; (b) mixing phenolic resin and ZrC dispersion liquid to form slurry; (c) immersing a two-dimensional carbon fiber sheet into the slurry for dipping and drying, then carrying out continuous superposition paving on the two-dimensional carbon fiber sheet, and carrying out curing and post-curing treatment to prepare a fiber-reinforced sintered body; (d) cracking the fiber-reinforced sintered body to obtain a porous C / C prefabricate; (e) placing silicon powder into a graphite crucible, burying the porous C / C prefabricate into the silicon powder, heating to 1,500-1,650 DEG C, and preserving heat for preset time so as to carry out liquid silicon permeation. The method can be used for improving the high-temperature oxidizing property and ablation property of the carbon fiber reinforced ceramic (C / C-SiC) composite material.

A process for hermetically packaging a microscopic structure including a MEMS device is provided. The process for the present invention includes the steps of depositing a capping layer of sacrificial material patterned by lithography over the microscopic structure supported on a substrate, depositing a support layer of a dielectric material patterned by lithography over the capping layer, providing a plurality of vias through the support layer by lithography, removing the capping layer via wet etching to leave the support layer intact in the form of a shell having a cavity occupied by the microscopic structure, depositing a metal layer over the capping layer that is thick enough to provide a barrier against gas permeation, but thin enough to leave the vias open, and selectively applying under high vacuum a laser beam to the metal proximate each via for a sufficient period of time to melt the metal for sealing the via.

The invention relates to a garment that protects against liquid and / or airborne contaminants and prevents transmission of human body odor. The garment includes a moisture vapor permeable, chemical and water impermeable microporous membrane arranged to form a barrier to chemical and particulate penetration and permeation through the garment. The membrane comprises a thermoplastic polymeric resin material and an activated carbon filler material distributed throughout the membrane and functioning both as a mechanical pore-forming agent for rendering the membrane microporous, and also as an adsorbent to render the membrane odor adsorptive.