The invention belongs to the technical field of pharmaceutical preparations, and relates to a riptacaine cream as well as a preparation method and application thereof, and the preparation method of the riptacaine cream comprises the following steps: preparing carbomer gel, preparing an
oil phase, preparing a water phase, primarily emulsifying, homogenizing and gelating, finely homogenizing and filling. According to the invention, polyoxyethylene (54) hydrogenated
castor oil is innovatively used as an auxiliary material, triple functions of a co-melting
solvent, an emulsifying agent and a stabilizing agent are realized at the same time, and any liquid
grease,
solvent or other surfactants do not need to be additionally added in the prescription. Through a unique'water-gel-oil '
composite structure design, oil drops are physically wrapped by a carbomer gel network and are positioned in network pores, so that the
mechanical stability superior to that of a conventional
emulsion is provided, and no layering is generated through high-speed centrifugal test
verification. In conclusion, the invention develops the riptacaine preparation which has the advantages of few types of auxiliary materials, higher stability, quicker effect taking and capability of expanding a new
dosage form and a new process.