The invention discloses a nano
iron oxide and
colla corii asini synergistic blood replenishing
nutrition formula and a preparation method thereof. The formula comprises the following components: 0.5-3% of surface functionalized nano
iron oxide, 0.5-3% of
colla corii asini and the balance of water. 30-50% of a
donkey-hide
gelatin matrix; 0.5 to 2.5% of
vitamin C or a
vitamin C derivative; 2-7% of
plant polysaccharide; 0.5-3% of a licorice extract; 40-55% of ice syrup; the preparation method comprises the following steps: dissolving the
donkey-hide
gelatin matrix, adding the premixed nano
iron oxide and
vitamin C derivative, carrying out
ultrasonic dispersion, sequentially adding other components, and carrying out homogenization treatment. According to the invention,
sodium citrate or
gelatin-coated nano iron
oxide is used as a high-efficiency
iron source and is matched with the blood replenishing effect of
donkey-hide gelatin to realize function
synergy; the
bioavailability of iron is remarkably improved through the compatibility of
vitamin C and
polysaccharide; the nutritional
powder has the advantages of traditional nourishing and modern nutritional supplement, and can be prepared into various dosage forms such as paste and soft sweets. In addition, the in-vitro
absorption rate is 1.8-2.5 times of that of a traditional
iron agent, the
gastrointestinal irritation is remarkably reduced, and the iron-containing compound preparation is particularly suitable for
nutrition intervention of people suffering from iron-deficiency
anemia.