11 results about "Toxicity reduction" patented technology

This invention relates to an immunotoxin targeting hematologic malignancies and its application. The immunotoxin comprises a toxic molecule and a carrier. The toxic molecule is pumpkin protein or a mutant of pumpkin protein. The carrier contains an antibody, ligand, or polypeptide capable of binding to hematologic malignancies cells. The antibody comprises an antibody fragment or a small molecule antibody. This invention provides an immunotoxin targeting hematologic malignancies for the treatment of these malignancies. The immunotoxin using a pumpkin protein mutant as the toxic molecule exhibits enhanced specificity against hematologic malignancies cells with high target expression, significantly increased activity in killing target cells, and allows for a substantial reduction in dosage and toxicity. In summary, the immunotoxin targeting hematologic malignancies using a pumpkin protein mutant as the toxic molecule offers advantages in both synergistic effect and reduced toxicity, and has broad application prospects.

The invention belongs to the technical field of application of traditional Chinese medicine preparations, and discloses application of Jinshuiliujun decoction in preparation of a medicine for treating EGFR sensitive mutation non-small cell lung cancer, the medicine is used for being applied in combination with chemotherapy, a classic traditional Chinese medicine compound is combined with a modern chemotherapy regimen, and when a patient suffering from IIIb / IV-stage EGFR sensitive mutation is treated, the curative effect is good, and the curative effect is good. The pharmaceutical composition shows clear synergistic interaction and toxicity reduction effects, and the specific performance is as follows: the median progression-free lifetime of a patient is obviously prolonged; the traditional Chinese medicine syndromes such as cough and weakness are improved; the immunologic function is effectively regulated, and the CD4 + / CD8 + ratio is increased; the negative emotion score of the patient is reduced; the adverse reaction incidence rate of chemotherapy is not increased; a brand new traditional Chinese and western medicine combined treatment scheme is provided for the specific lung cancer subtype, and the curative effect and life quality are improved.

The invention relates to the technical field of genetic engineering, in particular to a pasteurella multocida waaF gene and application thereof in attenuated live vaccines. The sequence of the pasteurella multocida waaF gene is as shown in SEQ ID NO: 1, and a delta waaF gene mutant strain is highly attenuated on ducks, has a certain in-vivo colonization level and has the potential of attenuated live vaccines. The mutant strain is immunized through oral administration and intramuscular injection, so that the production performance of ducks cannot be influenced, and 81.25% and 75% of immune protection can be provided for attacking toxic substances in the lethal dose of pasteurella multocida respectively. Compared with a delta grcA attenuated strain reported in the prior art, the delta waaF mutant strain shows higher-amplitude toxicity reduction, and shows more excellent safety and balanced immune effect only at the cost of a slightly low immune protection rate.

The application discloses a low-energy-consumption comprehensive wastewater toxicity reduction method, which comprises the following steps: (1) selecting a suitable electrode according to the B / C ratio of wastewater; (2) constructing a microbial electrochemical system; (3) enriching and culturing an electroactive biofilm; and (4) driving the microbial electrochemical system to treat industrial wastewater in an intermittent polarization mode. The application realizes the reduction of industrial wastewater toxicity under low energy consumption conditions, has the advantages of low energy consumption, simple operation and the like, and has practical significance for realizing standard and safe discharge of industrial wastewater.

The invention relates to a tannic acid modified cyclodextrin / curcumin / polyethyleneimine nano-composite as well as preparation and application thereof, and belongs to the technical field of biological materials. The method comprises the following steps: firstly, wrapping curcumin with sulfobutyl-beta-cyclodextrin sodium of which the outer edge is hydrophilic and the inner cavity is hydrophobic, then dropwise adding polyethyleneimine to form uniform nanoparticles, and finally dropwise adding tannic acid. According to the method, sulfobutyl-beta-cyclodextrin sodium is used as a solubilizing unit, polyethyleneimine is used as a delivery unit, curcumin is used as an active unit, and a composite nano material which is subjected to surface modification through tannic acid realizes multiple functions of solubilizing, delivery, toxicity reduction and activity synergy; the nanocomposite has the functions of drug release, anti-inflammation and antioxidation, and can exert the antioxidation and anti-inflammation activity for a long time.

The invention discloses an intelligent quintuplet synergistic sterilization, toxicity reduction and long-term storage system, which is composed of a cold plasma module, an ozone module, an NO authigenic system module, a chlorine dioxide module and a nitrogen barrier stability maintenance module, and an AI central control module is used for time sequence linkage and intelligent parameter adjustment. According to the system, ROS-RNS-AOS multistage free radicals react with an oxidation chain, molecular-level cracking and degradation of microorganisms and mycotoxins are achieved under the action of an electron layer excitation mechanism (ELAM), and the system has the characteristics of broad-spectrum efficient sterilization, deep toxicity reduction, low energy consumption and stability maintenance. The AI algorithm can automatically select a quintuplet mode, a quadruplet mode or a triple mode according to the pollution level, and the reaction energy and sequence are dynamically adjusted. The storage environment is kept in a low-oxygen clean stable state, and long-term mildew prevention, corrosion prevention and toxin regeneration prevention are realized. The system is suitable for grains, medicinal materials, seeds, nuts and animal raw materials, active intelligent prevention and control and green long-term storage are achieved, and the system belongs to a globally leading AI intelligent storage platform technology.

The invention discloses application of glycyrrhiza polysaccharide in preparation of a product for relieving toxicity of radix aconiti carmichaeli, and belongs to the technical field of medicines. Experiments prove that glycyrrhiza polysaccharide is a key active ingredient of liquorice for relieving the toxicity effect of radix aconiti carmichaeli, and the toxicity reducing effect of glycyrrhiza polysaccharide is closely related to improvement of arrhythmia symptoms of mice, reduction of the activity of cardiac toxicity indexes LDH and CK, reduction of the protein expression quantity of a myocardial injury marker cTnT and improvement of the myocardial fibrosis degree. The invention lays a theoretical foundation for clinical safe and effective application of radix aconiti carmichaeli and secondary development of related products.

The invention belongs to the technical field of biological medicines, and discloses an iron sulfide coated polydopamine nano material for toxicity reduction and efficacy enhancement of cervical cancer radiotherapy, and a preparation method and application of the iron sulfide coated polydopamine nano material. The method comprises the following steps: dissolving ammonium ferrous sulfate and trisodium citrate in ethylene glycol to obtain a solution A, dissolving polyethyleneimine in ethylene glycol to obtain a solution B, adding the solution B into the solution A, and stirring and reacting at normal temperature to obtain a mixed solution; adding a thioacetamide solution into the mixed solution, then dropwise adding triethanolamine, carrying out stirring reaction at normal temperature, carrying out solvothermal reaction after stirring is ended, and centrifuging and washing a product after the reaction is ended, so as to obtain a two-dimensional iron sulfide nanosheet; and adding dopamine hydrochloride, and stirring in absolute ethyl alcohol at room temperature to obtain the iron sulfide coated polydopamine nano material. The synthesis method is simple, convenient and high in operability; the synthesized product is stable and has repeatability; the traditional Chinese medicine composition can be used for sensitizing radiation therapy of cervical cancer, can relieve radiation colitis and reduce side effects of radiation therapy, and is beneficial to clinical application.

The invention relates to the technical field of medicines, in particular to application of a bufalin composition in preparation of a medicine for treating lung cancer. The bufalin composition comprises bufalin and a chicoric acid derivative, the molar ratio of the bufalin to the chicoric acid derivative is 1: (0.1-0.3). Experimental results show that the anti-tumor effect can be remarkably enhanced through the synergistic effect of the bufalin and the chicoric acid derivative, and the chicoric acid derivative can also achieve the dual optimization purposes of solubilization and toxicity reduction at the same time.

The application provides a low-pollution water efficient biological reinforcement treatment and toxicity reduction system and an operating method, comprising a pre-warning control system, a tail water treatment system, a receiving water body and a backflow system, characterized in that the tail water treatment system comprises, which are connected in sequence, an adjusting pond, an ecological pond, a drum microfilter, an anoxic tank, an MBBR tank, a secondary sedimentation tank and a clear water tank; the drum microfilter and the secondary sedimentation tank are connected with a sludge digestion tank respectively, and the sludge digestion tank is also connected with the anoxic tank. The application realizes the modularization of the treatment facility, improves the purification efficiency of the low-pollution tail water, solves the problems of the total amount of the tail water pollutant emission and the total amount of the toxicity reduction safe emission of the sewage treatment plant, and has the advantages of convenient detection, high sensitivity, convenient operation, low investment, environmental friendliness and the like, and can be adjusted to adapt to low C / N. When the system C / N is insufficient, the sludge digestion tank backflow supernatant is supplemented through a side flow to make up the carbon source of the system, so that the low C / N sewage treatment is realized.