4 results about "Toxicity reduction" patented technology

This invention relates to an immunotoxin targeting hematologic malignancies and its application. The immunotoxin comprises a toxic molecule and a carrier. The toxic molecule is pumpkin protein or a mutant of pumpkin protein. The carrier contains an antibody, ligand, or polypeptide capable of binding to hematologic malignancies cells. The antibody comprises an antibody fragment or a small molecule antibody. This invention provides an immunotoxin targeting hematologic malignancies for the treatment of these malignancies. The immunotoxin using a pumpkin protein mutant as the toxic molecule exhibits enhanced specificity against hematologic malignancies cells with high target expression, significantly increased activity in killing target cells, and allows for a substantial reduction in dosage and toxicity. In summary, the immunotoxin targeting hematologic malignancies using a pumpkin protein mutant as the toxic molecule offers advantages in both synergistic effect and reduced toxicity, and has broad application prospects.

The invention relates to a tannic acid modified cyclodextrin / curcumin / polyethyleneimine nano-composite as well as preparation and application thereof, and belongs to the technical field of biological materials. The method comprises the following steps: firstly, wrapping curcumin with sulfobutyl-beta-cyclodextrin sodium of which the outer edge is hydrophilic and the inner cavity is hydrophobic, then dropwise adding polyethyleneimine to form uniform nanoparticles, and finally dropwise adding tannic acid. According to the method, sulfobutyl-beta-cyclodextrin sodium is used as a solubilizing unit, polyethyleneimine is used as a delivery unit, curcumin is used as an active unit, and a composite nano material which is subjected to surface modification through tannic acid realizes multiple functions of solubilizing, delivery, toxicity reduction and activity synergy; the nanocomposite has the functions of drug release, anti-inflammation and antioxidation, and can exert the antioxidation and anti-inflammation activity for a long time.

The invention discloses an intelligent quintuplet synergistic sterilization, toxicity reduction and long-term storage system, which is composed of a cold plasma module, an ozone module, an NO authigenic system module, a chlorine dioxide module and a nitrogen barrier stability maintenance module, and an AI central control module is used for time sequence linkage and intelligent parameter adjustment. According to the system, ROS-RNS-AOS multistage free radicals react with an oxidation chain, molecular-level cracking and degradation of microorganisms and mycotoxins are achieved under the action of an electron layer excitation mechanism (ELAM), and the system has the characteristics of broad-spectrum efficient sterilization, deep toxicity reduction, low energy consumption and stability maintenance. The AI algorithm can automatically select a quintuplet mode, a quadruplet mode or a triple mode according to the pollution level, and the reaction energy and sequence are dynamically adjusted. The storage environment is kept in a low-oxygen clean stable state, and long-term mildew prevention, corrosion prevention and toxin regeneration prevention are realized. The system is suitable for grains, medicinal materials, seeds, nuts and animal raw materials, active intelligent prevention and control and green long-term storage are achieved, and the system belongs to a globally leading AI intelligent storage platform technology.