1815 results about "Tannic acid" patented technology

The invention relates to the field of membrane materials, and discloses an epoxy modified starch-based degradable membrane and a preparation method thereof, the epoxy modified starch-based degradable membrane comprises epoxidized starch, modified nanocellulose and a plasticizer; the modified nano cellulose is prepared by mixing a modified composite filler, a nano cellulose dispersion liquid and a zinc acetate dihydrate aqueous solution; the nano-cellulose dispersion liquid is prepared by adhering polytannic acid formed by oxidation and self-polymerization of tannic acid to the surface of nano-cellulose; the modified composite filler is prepared by performing carboxylation modification on nano titanium dioxide coated fumed silica nanoparticles by using succinic anhydride and gamma-aminopropyltriethoxysilane, then reacting with polyethyleneimine to obtain an aminated composite filler, and finally grafting glycidyl dodecyl dimethyl ammonium chloride to the surface of the aminated composite filler. The prepared film material is high in tensile strength, has certain hydrophobicity, and has good heat resistance, antibacterial property and flame retardant property.

The invention provides a hemostatic composition, a preparation method thereof and a hemostatic product. The hemostatic composition is prepared from the following raw material components in parts by mass: 0.01 to 0.5 part of cannabidiol, 10 to 150 parts of tannic acid modified carboxymethyl chitosan and 5 to 250 parts of crosslinked starch. The tannic acid modified carboxymethyl chitosan is prepared from the following raw material components in parts by mass: 45 to 55 parts of carboxymethyl chitosan and 0.5 to 1.5 parts of tannic acid. The cross-linked starch is prepared from the following raw materials in parts by mass: 95 to 105 parts of carboxymethyl enzymolysis starch and 2 to 5 parts of sodium trimetaphosphate. The hemostatic composition has a good hemostatic effect, and when the hemostatic composition is used in hemostatic products, the hemostatic products can have a good hemostatic effect.

The invention provides a bio-based adhesive and a preparation method thereof. Inspired by a spider thread structure, biomass adhesive interface enhancement based on a tannic acid adhesion group is combined with construction of a differential phase separation structure by biomass-induced polylipoic acid depolymerization, and a brand new strategy of adhesion-cohesion synergistic enhancement of the adhesive strength of the adhesive is realized. According to the invention, tannic acid and carboxymethyl chitosan are introduced into a lipoic acid-based adhesive, so that the purpose of synergistically enhancing the bonding performance of the adhesive through adhesion-cohesion is achieved, and the defects of weak cohesion, low bonding strength, poor water resistance, poor moisture resistance and the like of the conventional biomass adhesive are overcome. Benefited from a new strategy of adhesion-cohesion synergistic enhancement, the biomass adhesive has good adhesive strength in various environments and materials. In addition, the biomass adhesive also has the characteristics of biological safety, antibacterial and mildew-proof properties and recoverability, so that the product has wider application and potential compared with the previous product, and has a good application prospect.

The invention discloses preparation and application of bionic cerium-based polyphenol nano-enzyme for treating rheumatoid arthritis, and belongs to the field of medical preparations. The method comprises the following steps: respectively complexing cerium ions and tannic acid or epicatechin gallate to prepare cerium-based polyphenol nano-enzyme, and then preparing the cerium-based polyphenol nano-enzyme wrapped by a macrophage membrane. And loading the cerium-based polyphenol nano-enzyme wrapped by the macrophage membrane into the hydrogel to prepare the hyaluronic acid-based hydrogel. The cerium-based polyphenol nano-enzyme and the hyaluronic acid-based hydrogel are characterized, it is verified that the cerium-based polyphenol nano-enzyme and the hyaluronic acid-based hydrogel are successfully synthesized, the particle size of CeTA is about 22 nm, the particle size of M-CeTA is increased to 273 nm, the particle size of CeECG is about 95 nm, and the particle size of M-CeECG is increased to 292 nm. In-vitro experiments prove that the M-CeTA and the M-CeECG do not show obvious cytotoxicity when being less than 80 mu g / mL, and have an obvious inhibition effect on expression of cell inflammatory factors on inflammatory cells.

The invention discloses a film coating agent for accelerating stabilization of a weathering resistant steel rust layer in a severe atmospheric environment. The film coating agent comprises a film-forming agent and a spraying agent, the film-forming agent comprises a gel agent and a transforming agent; the gel is prepared from one or more of tannic acid, carbomer, chitosan and gelatin; the transforming agent comprises one or more of magnesium sulfate, zinc sulfate and sodium molybdate; the spraying agent comprises an accelerant and an aggressive agent; the accelerant comprises one or more of sodium sulfate, potassium sulfate and chromium sulfate; the aggressive agent comprises one or more of sodium chloride, aluminum chloride and sodium fluoride. The film coating agent provided by the invention can form a stable and uniform rust layer on the surface of the weathering resistant steel, so that the corrosion resistance of the weathering resistant steel is improved.

The invention discloses high-thermal-conductivity carbon black and a preparation method and application thereof, and relates to the technical field of carbon black modification.The preparation method of the high-thermal-conductivity carbon black comprises the following steps that carbon black is subjected to oxidation treatment, silanization treatment and tannic acid coating treatment, and modified carbon black is obtained; preparing a graphene / boron nitride / modified carbon black multi-dimensional filler; carrying out primary modification on the graphene / boron nitride / modified carbon black multi-dimensional filler by adopting lignin, polyvinylpyrrolidone and samarium chloride, and then carrying out secondary modification by adopting 6-aminocaproic acid to obtain the high-thermal-conductivity carbon black. The high-thermal-conductivity carbon black prepared by the invention not only has good dispersity, but also can well improve the thermal conductivity and mechanical properties of a rubber matrix.

The invention provides an antibacterial synergy-mineralization regulation difunctional nano material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: mixing a disodium hydrogen phosphate solution and a calcium chloride solution to obtain an amorphous calcium phosphate suspension; mixing the amorphous calcium phosphate suspension with a tannic acid solution to obtain an ACP-TA suspension; and finally, mixing the ACP (at) TA suspension and the hydroxypropyl trimethyl ammonium chloride chitosan solution to obtain the bifunctional nano material. A cross-linked shell is formed through the electrostatic adsorption effect of tannic acid and hydroxypropyl trimethyl ammonium chloride chitosan of the antibacterial layer, amorphous calcium phosphate is effectively wrapped, the crystallization process of amorphous calcium phosphate can be remarkably delayed, long-acting release of calcium and phosphorus ions is ensured, the antibacterial function can be effectively achieved, and the service life of the coating is prolonged. An ideal local microenvironment is provided for remineralization of tooth hard tissue, and finally biomimetic mineralization of enamel and deep mineralization plugging of dentinal tubules are achieved.

The invention belongs to the technical field of biological medicines, and particularly relates to hydrogel with photo-thermal multiple antibacterial and hemostatic functions. The multifunctional hydrogel is prepared from epsilon-polylysine (EPL), gallic acid (GA), tannic acid (TA) and ferric trichloride hexahydrate. The polyphenols are obtained through multiple mechanisms such as reaction between the polyphenols and amino groups, metal chelation, pi-pi interaction and electrostatic attraction (as shown in Figure 1). The metal ion and multiple dynamic cross-linking system hydrogel is constructed, the hydrogel with positive charges enriched on the surface can act with blood platelets with negative charges, red blood cell aggregation, blood platelet adhesion and vasoconstriction effects are promoted, and the blood coagulation efficiency is improved. The hydrogel shows excellent antibacterial performance and photo-thermal performance, can prevent infection in the inflammation stage of wound healing, can effectively accelerate wound healing, and has good biological safety.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a synthetic nicotine composition and a preparation method thereof. The nicotine buccal film agent disclosed by the invention is prepared from the following components in parts by weight: 2 to 4 parts of nicotine clathrate compound powder, 0.2 to 0.6 part of phosphatidic acid, 0.1 to 0.3 part of tannic acid, 0.1 to 0.2 part of sodium ascorbate, 0.04 to 0.06 part of tocopherol, 0.01 to 0.02 part of ethylene diamine tetraacetic acid, 2 to 4 parts of povidone and 40 to 80 parts of absolute ethyl alcohol. The synthesized nicotine composition prepared by the invention can effectively relieve the phenomenon that the faster the nicotine is released, the stronger the bitter taste is. Meanwhile, in a high-temperature and high-humidity environment, the stability of nicotine can be effectively maintained, and the oxidation half-life period of nicotine is prolonged.

The invention discloses a rapid hemostasis powder material for massive hemorrhage. The rapid hemostasis powder material for massive hemorrhage is tannic acid modified carboxymethyl chitosan. The invention also provides a preparation method and application of the rapid hemostasis powder material for massive hemorrhage, and a rapid hemostasis microgel composition containing the rapid hemostasis powder material for massive hemorrhage. The rapid hemostasis powder material and microgel composition for massive hemorrhage have excellent water solubility, hemostasis performance and biocompatibility, have multiple effects of sterilization, anti-inflammation, wound healing promotion and the like, and are beneficial to rapid healing of wound parts after hemostasis.

The invention relates to a high-barrier antibacterial polylactic acid packaging material and a preparation method thereof, and belongs to the technical field of biodegradable packaging materials. The technical problems that a traditional polylactic acid material is insufficient in barrier property, poor in antibacterial performance and difficult to meet the packaging requirements of livestock and poultry meat, food and medicine are solved. A graphene oxide lamellar material is subjected to copper ion functionalization treatment and is bridged with tannic acid molecules through copper ions to form a nano filler, and then the filler is blended with a plasticized polylactic acid solution to prepare the membrane. The preparation method comprises the following steps: preparing a copper ion functionalized dispersion liquid from graphene oxide and copper nitrate, self-assembling the copper ion functionalized dispersion liquid and tannic acid under the condition that the pH is 8-10 to generate a nanofiller, uniformly dispersing the nanofiller, mixing the nanofiller with polylactic acid, polyethylene glycol and glycerol according to a specific mass ratio, coating to form a film, and controlling solvent volatilization conditions to obtain the high-performance packaging material. According to the method, the oxygen barrier property and the antibacterial activity of the material are remarkably improved through uniform dispersion of the nanofiller and reinforcement of a coordination network. The obtained material is suitable for packaging foods such as livestock and poultry meat.

The invention provides a self-repairing hydrated salt phase change microcapsule as well as a preparation method and application thereof, and belongs to the field of phase change materials. The preparation method comprises the following steps: preparing a hydrated salt phase change material and sorbitol into eutectic melt by adopting a melting method; strontium carbonate, sorbitol grafted nano titanium dioxide, SiO2-coated silicone rubber microspheres, hollow Al2O3 microspheres, tannic acid microcapsules, alpha-zirconium phosphate, melamine polyphosphate, diethyl aluminum hypophosphite, carboxylated multi-walled carbon nanotubes, polydopamine modified boron nitride nanosheets and hydrophilic fumed silica are added into the eutectic melt, and blending is performed to obtain a core material; The preparation method comprises the following steps: adding strontium carbonate, sorbitol grafted nano titanium dioxide, SiO2-coated silicone rubber microspheres, hollow Al2O3 microspheres, tannic acid microcapsules, alpha-zirconium phosphate, melamine polyphosphate, diethyl aluminum hypophosphite, carboxylated multi-walled carbon nanotubes, polydopamine modified boron nitride nanosheets and hydrophilic fumed silica into the eutectic melt; bio-based polyurethane-polyurea is used as a shell material, the core material is coated in the shell to prepare the microcapsule, and the temperature of the coating operation is not higher than the phase change temperature of the hydrated salt phase change material; the surface is coated with a super-hydrophobic coating. According to the invention, a solid filler system is constructed, and a low-temperature preparation process is combined, so that the phase-change microcapsule with high performance, high reliability and high safety is developed.

The invention discloses a nano-antibacterial agent for treating biofilm infection through Prussian blue and a preparation method and application thereof.According to the nano-antibacterial agent, hollow Prussian blue (HPB) serves as a carrier to load a substance with anti-inflammatory and anti-oxidation effects, a metal polyphenol network structure is formed through chelating of tannic acid (TA) modified by hyaluronic acid (HA) and high-valence metal ions, and the nano-antibacterial agent is used for treating biofilm infection through Prussian blue. And the MPNs are packaged to obtain the product. All the components of the nano antibacterial agent have a synergistic effect, MPNs formed by chelating TA modified by hyaluronic acid and high-valence metal ions in the antibacterial agent have good photo-thermal performance, and light energy can be converted into heat energy for photo-thermal therapy. According to the invention, the nanoparticles for photo-thermal antisepsis and anti-inflammation are constructed, so that comprehensive treatment of anti-biofilm and anti-inflammatory effect is realized, and healing of infected parts is promoted. And the antibacterial agent has good biocompatibility and high biological safety, and is very suitable for replacing antibiotics to treat biological membrane infection.

The invention relates to the technical field of dental restoration materials, in particular to a bacteriostatic dental restoration composite film and a preparation method thereof. The oral cavity restoration composite film is composed of an upper-layer antibacterial film, a middle-layer polycaprolactone fiber film and a lower-layer bone restoration film. The upper-layer antibacterial film is prepared from the following components in parts by weight: 3 to 4 parts of cinnamon essential oil, 0.5 to 1 part of xanthan gum, 0.5 to 1 part of seed meal protein, 0.1 to 0.15 part of tannic acid, 5 to 7 parts of silk fibroin, 1 to 1.5 parts of polylactic acid, 0.6 to 1 part of chitosan, 1 to 1.5 parts of polyvinyl alcohol and 1.5 to 2.5 parts of glycerol; the lower-layer bone repair membrane is prepared from the following raw materials in parts by weight: 2 to 3 parts of nano-hydroxyapatite, 3 to 5 parts of citric acid, 6 to 9 parts of lactic acid, 3 to 4 parts of tyrosine, 1 to 2 parts of glycollic acid, 2 to 3 parts of casein, 0.2 to 0.3 part of hyperoside and 1 to 2 parts of gelatin.

The invention belongs to the technical field of concrete, and relates to high-strength anti-crack concrete and a preparation method thereof. The invention provides a preparation method of concrete. The preparation method comprises the following steps: preparing a modifier from tannic acid, starch and water; fibers are immersed in the modifier for modification to prepare modified fibers, and the modified fibers and basic concrete are mixed to prepare the concrete, the foundation concrete comprises ordinary Portland cement, coarse aggregate, fine aggregate and water. The technical problem that the anti-cracking capability of the concrete in a high-temperature dry environment is reduced when tannic acid is used for improving the strength of the foundation concrete is solved.

The invention discloses a preparation method of a TA modified aminated ZIF-90 polyamide reverse osmosis membrane, which comprises the following steps: by taking a self-made polysulfone membrane as a base membrane, firstly soaking the base membrane in a water phase solution, then soaking the base membrane in an oil phase solution containing aminated ZIF-90, then treating the base membrane with a tannic acid (TA) / ethanol solution, and finally performing heat treatment to obtain the target polyamide reverse osmosis membrane. Aminated ZIF-90 is used for modifying a polyamide membrane, then TA is used for modifying a surface layer, and compared with an original membrane, the prepared membrane material is effectively improved in water flux and salt interception; after chlorine treatment, the attenuation rate of water flux and salt interception is smaller than that of the original membrane, which indicates that the chlorine resistance of the modified polyamide membrane is superior to that of the original membrane; meanwhile, the modified polyamide membrane has excellent anti-pollution performance.

The invention relates to a hyaluronic acid-polyurethane composite material based on a double dynamic network and a preparation method and application thereof, and the preparation method comprises the following steps: carrying out hydrophobic modification reaction on hyaluronic acid and aminophenylboronic acid to obtain aminophenylboronic acid modified hyaluronic acid; the preparation method comprises the following steps: mixing polytetrahydrofuran ether glycol, polyethylene glycol and isophorone diisocyanate, carrying out a primary reaction, adding trimethylolpropane tri (3-mercaptopropionic acid) ester, carrying out a secondary reaction, adding tannic acid, and carrying out a third reaction to obtain tannic acid-terminated dynamic thionocarbamate polyurethane; and mixing the amino phenylboronic acid modified hyaluronic acid with the tannic acid terminated dynamic thionocarbamate polyurethane for reaction to obtain the hyaluronic acid-polyurethane composite material with the double dynamic networks. Compared with the prior art, by introducing a'thionocarbamate-borate 'double-dynamic network, high toughness, high strength, good self-repairability and repeatable processability in an extreme environment are realized, and the material is particularly suitable for manufacturing and repairing of key components in an LNG ship body and a heat insulation system thereof.

A material for producing macromolecule air fibers, a preparation method, and an application thereof are provided. The material for producing macromolecule air fiber is prepared by preparation of doped antibacterial TiO2 / ZnO / ZrO2 ceramic powder, deposition of magnetic iron oxide, surface modification with tannic acid, addition of water-soluble chitosan solution, immersion in a spined TPEE air fiber membrane, uniform addition of Genipin solution, heating and reacting, membrane removal, washing, and drying. The TPEE air fiber membrane produced by the present disclosure has good mechanical properties, and modified ceramic powder is uniformly dispersed in the TPEE air fiber membrane, which plays a good role in antibacterial, environmental protection, immune regulation, magnetic therapy, far-infrared heating and other effects, rendering the material for producing macromolecule air fibers have better comprehensive performance and a good mattress support material with broad application prospects.

The invention relates to the technical field of powder metallurgy, and particularly discloses an ultra-coarse grain WC-Co hard alloy and a preparation method thereof.The preparation method comprises the following steps that S1, the following raw materials including, by weight, 4.6-9.2 parts of cobalt powder, 96-102 parts of coarse grain tungsten carbide powder, 3.6-5.2 parts of functional gel, 3.4-4.6 parts of modified penetration enhancer, 2.2-2.8 parts of binder and 36-62 parts of organic solvent are prepared; step S2, preparation of a mixture; step S3, carrying out granulation treatment; step S4, compacting; step S5, pressurizing and sintering; the functional gel and the modified penetration enhancer are added, the functional gel contains yttrium oxide, polytannic acid, ultrafine tungsten carbide, tantalum carbide, chromium carbide, silica gel and other components, and the functional gel not only has excellent physical properties, but also can be cross-linked with the modified penetration enhancer to form a more compact silicon dioxide network structure; and the hardness, toughness, impact resistance and wear resistance of the alloy are improved.

The invention belongs to the field of preparation of organic fertilizers, and particularly relates to a moisturizing and drought-resisting bio-organic fertilizer and a preparation method thereof. The preparation method comprises the following steps: carrying out a cross-linking reaction on a boiled and crushed starch matrix, carboxymethyl cellulose and epoxy chloropropane to form a compound solution, and mixing the compound solution with mixed animal bone meal capable of enhancing the stress resistance of plants, so that the obtained nutritional base material can quickly provide nutrients for the plants for a long time; kelp and seaweed are mixed and ground into thick liquid, under the combined action of calcium chloride and tannic acid, a three-dimensional net-shaped structure is formed, the plant component containing the fungicide is put into the colloid component, and the obtained moisture-preserving and drought-resisting component can keep soil moisture for a long time; the long-acting stability-maintaining suspension can form a protective layer on the surface of soil, the moisturizing and drought-resisting component and the organic fertilizer mixture are mixed, and the prepared moisturizing and drought-resisting bio-organic fertilizer can efficiently and rapidly provide nutrients for crops, has the moisturizing and drought-resisting capacity and can play the moisturizing and drought-resisting roles in a long term.

Disclosed is preparation of dual cross-linked zein-carboxymethyl chitosan nanoparticles for improving the thermal stability of polyphenol. After covalently cross-linked zein, tannic acid is used to prepare tannic acid cross-linked zein-carboxymethyl chitosan nanoparticles loaded with quercetin, Ca2+ is then added to increase a degree of crosslinking between the tannic acid and the carboxymethyl chitosan, as well as between molecules of the carboxymethyl chitosan in the zein nanoparticles to make the structure tighter, such that structural stability of the nanoparticles can be maintained during the thermal processing after the nanoparticles are formed, the quercetin encapsulated inside is protected well, and a retention rate of quercetin during the thermal processing is improved. The method provided in the present disclosure is simple, green, pollution-free and low energy consumption, and the prepared nanoparticles can improve the thermal stability of quercetin, and can be used as a natural additive for thermal processing of food.

The invention relates to the field of immobilized enzymes, in particular to immobilized lipase with graft-modified amino resin as a carrier and a preparation method thereof.The method comprises the steps that firstly, the amino resin is modified through the oxidative auto-polymerization characteristic of tannic acid, and first modified amino resin is obtained; and modifying the first modified amino resin by using fatty amine as a hydrophobic modifier to obtain second modified amino resin. Then lipase is fixed on the second modified amino resin through physical adsorption, the lipase is subjected to interfacial activation on an amphiphilic interface on the second modified amino resin, and a part of lipase is covalently bound with quinonyl in an activated state, so that the immobilized lipase with high activity and stability is obtained. The method is easy to operate, green and non-toxic, the prepared immobilized lipase is good in enzyme activity and stability, and the method can be used for preparing the immobilized lipase on a large scale, can be applied to the field of food and has industrial application potential.

The invention provides an additive composition containing a bioactive enzyme and a preparation method of the additive composition, and belongs to the technical field of biological enzymes. The preparation method comprises the following steps: fixing phytic acid and cyclodextrin on hydroxyapatite, modifying with tannic acid, reacting with dithiothreitol modified lysozyme to prepare an immobilized compound, adding 2, 2-dimethoxy-2-phenylacetophenone and methyl methacrylate, and carrying out irradiation reaction with an ultraviolet lamp to prepare the additive composition containing the bioactive enzyme. The broad-spectrum antibacterial property and the antiviral property of the lysozyme are greatly improved, the sterilization effect on gram negative bacteria is obviously improved, meanwhile, the stability of enzyme is greatly improved, the enzyme is not prone to inactivation, the preservation time of the enzyme is prolonged, the application effect of the enzyme is widened, meanwhile, the lysozyme has good killing capacity on oral bacteria and viruses, the addition of preservatives is reduced, and the cost is reduced. The cleaning effect and stability of the product are improved, tooth demineralization can be prevented, decayed teeth can be prevented, and wide application prospects are achieved.

The invention discloses a sliding plate brick and a preparation method thereof, and relates to the technical field of sliding plate bricks. The sliding plate brick comprises the following raw materials in parts by weight: 30-50 parts of tabular corundum, 20-30 parts of white corundum, 8-12 parts of graphite, 2-5 parts of carbon black, 3-5 parts of metal aluminum powder, 4-6 parts of a binder and 2-4 parts of silicon carbide. The preparation method comprises the following steps: reacting hydroxyl in sodium alginate with chlorine atoms in 4-chlorophenylboronic acid under the action of potassium carbonate to generate boric acid modified sodium alginate; boric acid bonds in the boric acid modified sodium alginate react with hydroxyl groups in tannic acid to generate tannic acid composite sodium alginate; hydroxyl in the tannic acid composite sodium alginate reacts with silicon hydroxyl in the triphenyl hydroxysilane under the action of phosphoric acid to generate the binder. The prepared sliding plate brick has good compression strength and high-temperature fracture resistance.

The invention relates to the technical field of tannic acid waste liquid, and discloses a tannic acid production wastewater purification device which comprises a reaction cylinder, one side of the upper portion of the reaction cylinder is fixedly communicated with a liquid inlet pipe, the outer wall of the liquid inlet pipe is fixedly connected with a liquid inlet valve, the bottom of the reaction cylinder is fixedly communicated with a liquid outlet bin, and the outer wall of the liquid outlet bin is fixedly connected with a liquid outlet valve. A fixing frame is fixedly installed on the outer wall of the reaction cylinder, the top of the reaction cylinder is symmetrically and fixedly communicated with air outlet pipes, a liquid separation assembly is arranged in the reaction cylinder, a stirring assembly is arranged outside the liquid separation assembly, and chemicals are added into all areas in the reaction cylinder through the liquid separation assembly. The uniform distribution of the medicament can ensure that pollutants in the wastewater are in full contact with the medicament, the situation that the concentration of the local medicament is too high or too low is avoided, and the arranged stirring assembly is matched to ensure that the wastewater in the whole reaction cylinder can be effectively treated, so that the reaction effect is optimized, and the wastewater treatment quality is improved.

The invention belongs to the technical field of biomedical materials, and particularly relates to a multi-layer multifunctional hydrogel microsphere for diabetic wounds as well as a preparation method and application of the multi-layer multifunctional hydrogel microsphere. The preparation method comprises the following steps: firstly, synthesizing a chitosan derivative with proper amino and aldehyde group contents, oxidized macromolecules and modified chitin; then preparing photocuring hydrogel microspheres by utilizing a microfluidic technology, and sequentially immersing the photocuring hydrogel microspheres into an oxidized polymer solution, a modified chitin solution, a tannic acid solution and a metal salt solution, so as to construct the hydrogel microspheres with a multifunctional layer structure. The invention further provides specific application intervals of parameters such as solvents used by various solutions, concentration ranges and soaking time. The preparation method provided by the invention has expansibility and universality, various types of microspheres can be constructed for sequential release of bioactive substances, and the requirements of tissue repair are met.

The invention discloses application of tannic acid combined triazole medicines in preparation of medicines for treating diseases caused by fungi, and belongs to the technical field of antifungal. A series of drug sensitive tests show that tannic acid lower than 3 [mu] g / ml has no influence on the activity of human vaginal epithelial cells, and after the tannic acid is combined with fluconazole, the tannic acid can significantly inhibit the growth activity of drug-resistant candida (including drug-resistant candida albicans and drug-resistant candida glabrata). In view of the natural property, wide source and low toxicity of tannic acid, the invention provides a new antifungal treatment strategy, and the tannic acid has important clinical application value for treating infection (such as vaginal candidiasis) caused by drug-resistant fungi, especially under the condition that the existing antifungal drugs are poor in effect. Therefore, the tannic acid combined triazole medicine can be used for preparing the medicine for treating diseases caused by fungi.

The invention belongs to the technical field of emulsion materials, and particularly relates to metal-polyphenol network modified coconut protein composite particles as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing a coconut protein-pectin compound by taking coconut protein and pectin as raw materials, adding a tannic acid solution into the coconut protein-pectin compound, mixing, adding a Fe < 3 + > solution, and mixing to obtain metal-polyphenol network modified coconut protein composite particles; according to the preparation method, tannic acid and the coconut protein-pectin compound are subjected to non-covalent interaction, Fe < 3 + > and phenolic hydroxyl groups on the tannic acid are subjected to coordination reaction, a metal-polyphenol network is formed through cross-linking of Fe-O coordination bonds, and a compact modification layer is constructed on the surface of the coconut protein-pectin compound, so that on one hand, waste coconut protein resources are utilized; on the other hand, the problem that composite particles prepared from pectin and coconut protein are prone to depolymerization is solved, the structural stability is improved, and meanwhile iron and polyphenol are supplemented.

The invention discloses anti-attrition lubricating oil suitable for minimal quantity lubrication and a preparation method thereof, and belongs to the technical field of lubricating oil, molybdenum disulfide is nucleated and grows on the surface of porous cerium oxide nanosphere powder to form a cerium oxide and molybdenum disulfide compound, then modified silicon dioxide and tannic acid are pre-polymerized to form silicon dioxide prepolymer powder, and the silicon dioxide prepolymer powder is subjected to ball milling to obtain the anti-attrition lubricating oil suitable for minimal quantity lubrication. The preparation method comprises the following steps: taking a cerium oxide molybdenum disulfide compound as a core material, taking silicon dioxide prepolymer powder and an N-isopropylacrylamide polymer as a shell to obtain a composite temperature-sensitive microcapsule, and mixing the composite temperature-sensitive microcapsule with other raw materials to prepare the composite temperature-sensitive microcapsule. The outer-layer shell polymer chain of the composite temperature-sensitive microcapsule in the anti-attrition lubricating oil shrinks, the cerium oxide molybdenum disulfide compound inside is released, and controllable release of the inner core material is realized by using the temperature sensitivity of the shell polymer of the composite temperature-sensitive microcapsule and the external temperature change during operation.

The invention provides efficient gelatin hemostatic microspheres as well as a preparation method and application thereof, the preparation method comprises the following steps: mixing a gelatin solution with a tannic acid solution, and uniformly stirring to obtain a tannic acid modified gelatin aqueous solution; uniformly mixing span-80 with liquid paraffin to obtain an oil phase; adding the tannic acid modified gelatin aqueous solution into an oil phase, and uniformly stirring to obtain a mixed solution; the mixed solution is subjected to a cross-linking reaction under the ice bath condition, after the cross-linking reaction is completed, a reaction solution and acetone are mixed, liquid paraffin is removed after standing, and the tannic acid modified hemostatic microspheres are obtained after drying; mixing the tannic acid modified hemostatic microspheres with an adsorbent, and dehydrating to obtain the gelatin hemostatic microspheres. The prepared gelatin hemostatic microspheres can be attached to the surface of tissue and have the effects of high water absorption and rapid hemostasis.