892results about "Esterified saccharide compounds" patented technology

The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I):tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

The present disclosure includes ionizable lipids suitable for lipid nanoparticle compositions and pharmaceutical formulations thereof. The lipids have general formula (I).

The invention relates to the technical field of biology, and particularly discloses a method for removing lactulose-based isomers in an oligosaccharide separation and purification process. The method comprises the following steps: taking oligosaccharide fermentation liquor for producing oligosaccharide through fermentation by using lactose as a substrate, sequentially carrying out thallus removal, decoloration, electrodialysis desalination, ion exchange resin desalination, concentration, sequential simulated moving bed chromatographic purification, ultrafiltration, re-concentration and spray drying, and detecting the oligosaccharide and the lactulose-based isomer in the oligosaccharide. According to the method disclosed by the invention, the content of lactulose-based isomers in the separation and purification process is greatly reduced, so that the product purity is effectively improved; the method can be applied to the synthesis process of other milk oligosaccharides such as fucose lactose (FL), lactose-N-tetraose (LNT), lactose-N-neotetraose (LNnT), lactose-N-fucopentasaccharide (LNPFI) and the like or other carbohydrates containing a lactosyl group, has a very high application value, and accords with laws and regulations.

The invention discloses a genetically engineered bacterium for producing glucuronic acid as well as a construction method and application of the genetically engineered bacterium, and belongs to the technical field of genetic engineering. According to the genetically engineered bacterium for producing glucuronic acid, an inositol oxidase gene MMIOX is integrated on a site of a uronic acid isomerase gene uxaC. According to the invention, an inositol oxidase gene MMIOX is integrated on a genome of a genetically engineered bacterium for producing glucuronic acid, and a uronic acid isomerase gene uxaC is knocked out at the same time, so that the genetically engineered bacterium can efficiently catalyze inositol reaction to generate glucuronic acid through the integrated inositol oxidase gene MMIOX; the glucuronic acid isomerase gene uxaC is knocked out, so that isomerization reaction of glucuronic acid can be avoided, and the yield of glucuronic acid is further increased.

The invention relates to the technical field of oxidation resistance, in particular to a glutamic acid derivative, a preparation method thereof and application of the glutamic acid derivative in rhythm gene regulation and oxidation resistance. The glutamic acid derivative has a structure as shown in a formula I. The glutamic acid derivative provided by the invention can up-regulate expression of CLOCK protein and Per3 protein, can inhibit ROS in cells and up-regulate expression of Nrf2, and can be applied to relieving skin problems caused by disorder of circadian rhythm. # imgabs0 #

The invention discloses a toughening agent, a toughened epoxy resin adhesive and a preparation method and application thereof. The toughening agent is obtained by carrying out esterification reaction on components including a phenolic compound containing a polyphenol skeleton and an anhydride compound containing a long-chain alkyl structure. The raw materials used by the toughening agent are bio-based molecules and have excellent renewability, the toughening agent is high in toughening efficiency, the impact strength of the epoxy resin adhesive can be effectively improved under the condition of low addition amount, and meanwhile, the bonding strength and the hydrothermal durability of the epoxy resin adhesive can be improved.

To provide a compound capable of forming an organogel.SOLUTION: The compound is represented by the structural formula in the figure, where A represents hydrogen or OR, and each R is independently selected from the group consisting of hydrogen, a C10-22 linear alkyl group, an acyl group derived from a C10-22 linear saturated fatty acid, and an acyl group derived from a γ-amino butyric acid derivative.SELECTED DRAWING: None

The invention discloses a ferroptosis inhibitor and application of the ferroptosis inhibitor in radiation pneumonitis drugs, and relates to the technical field of biological medicines. The specific preparation method comprises the following steps: adding the ferroptosis inhibitor and the auxiliary agent into the solvent, and dissolving to obtain the ferroptosis inhibitor composition; wherein the ferroptosis inhibitor is isoorientin; the auxiliary agent is a glucosamine derivative; the solvent is a serum-free DMEM culture medium. The ferroptosis inhibitor composition prepared by the method provided by the invention can effectively reduce the rise of active oxygen, ferrous ions and malondialdehyde levels of human pulmonary epithelial cells BEAS-2b and mouse pulmonary epithelial cells MLE-12 caused by irradiation, restore cell mitochondrial membrane potential enrichment and inhibit the expression of various inflammatory factors in irradiated cells; therefore, the process of radiation pneumonitis is remarkably improved, and a new medication strategy is provided for research on radiation pneumonitis drugs.

The present disclosure provides linker compounds of Formula (I) or (II):pharmaceutically acceptable salts thereof, and related scaffolds and conjugates. The present disclosure also relates to uses of the linker compounds, scaffolds, and conjugates, e.g., in delivering nucleic acid and / or treating or preventing diseases.

Disclosed herein is a modified ribonucleotide comprising a nucleoside comprising 2′-O-acetylated ribose, and polyribonucleotides comprising the same. Also provided herein are compositions comprising a polyribonucleotide of the present disclosure and methods of making and using the same.

Described herein are methods of syntheses and therapeutic uses of covalently modified peptides and / or proteins. The covalently modified peptides and / or proteins allow for improved pharmaceutical properties of peptide and protein-based therapeutics.

The invention provides a hydrogel dressing for wound repair and a preparation method thereof, and the hydrogel dressing is prepared from the following components in percentage by mass: 4.5 to 6.5 percent of unsaturated sugar-containing ester monomer, 2.0 to 2.5 percent of nonionic soluble cellulose, 7 to 10 percent of methacrylic anhydride quaternary ammonium salt, 18 to 20 percent of butanediol and the balance of water. The preparation method comprises the following steps: coupling beta-D glucose pentaacetate with hydroxyethyl methylacrylate through a condensation reaction to obtain a polymerizable unsaturated sugar-containing ester monomer, and then copolymerizing the polymerizable unsaturated sugar-containing ester monomer with methacrylic anhydride quaternary ammonium salt during preparation of the hydrogel dressing. According to the hydrogel dressing, due to introduction of a hydrophobic component and a polyelectrolyte component, ultrahigh strength and water content can be kept at the same time, and the hydrogel dressing has a remarkable hemostatic effect, excellent antibacterial ability and good cell compatibility and has the potential of serving as a dressing for rapid wound repair.

The invention relates to the technical field of bioengineering, in particular to a method for separating and extracting sialic acid from fermentation liquor, which comprises the following steps: filtering and purifying by using an inorganic membrane separation system and an organic ultrafiltration membrane, concentrating by using a reverse osmosis membrane, removing impurities by ion exchange, decoloring, concentrating under reduced pressure and freeze-drying. And finally, a high-purity sialic acid product is obtained at a relatively high yield. The method provided by the invention is simple to operate, a sialic acid finished product with the purity of 99% or above can be obtained after crystallization, and the whole process is green and environment-friendly and has no environmental pollution.

The present disclosure provides a Lipid-Based Lipid Agent being a compound of Formula (I), (II), (III), or (IV):or pharmaceutically acceptable salts thereof, and related conjugates. The present disclosure also relates to uses of the Lipid-Based Lipid Agents and conjugates, e.g., in delivering nucleic acid and / or treating or preventing diseases.

The invention relates to the technical field of biology, in particular to a method for purifying 6-sialic acid lactose. According to the 6-sialic acid lactase reaction liquid prepared based on multi-enzyme catalysis, the high-efficiency, high-purity and high-recovery-rate purification method of the 6-sialic acid lactase is developed by combining membrane separation and simulated moving bed chromatography technologies, meanwhile, less wastewater is generated, the cost benefit is high, and continuous large-scale production can be achieved.

The invention belongs to the technical field of pesticides, and particularly relates to azobenzene calix [4] arene derivatives as well as a preparation method and application thereof. The invention discloses a novel azobenzene calix [4] arene derivative prepared by directional modification through an azo reduction reaction based on a calix [4] arene skeleton. The azobenzene calix [4] arene derivative has the characteristics of green environmental protection, accurate and controllable structure and efficient synthesis. After the derivative and a pesticide form a host-guest compound, the activity of the pesticide can be remarkably improved, the bioavailability of the pesticide at an action site is increased, the problem of low efficiency of the traditional pesticide is effectively solved, and the development of target drug resistance is delayed. The technology breaks through the technical bottleneck of nano-carrier environmental toxicity, provides a new thought for developing a multi-target and low-environmental-risk pesticide synergist, and has important significance for realizing pesticide decrement, synergism and resistance treatment.

The invention discloses application of tannin compounds in preparation of drugs for resisting porcine reproductive and respiratory disorder viruses. The inventor of the invention performs activity screening on natural tannin compounds, and finds that the tannin compounds as shown in the formula 1 have excellent anti-PRRSV activity, and the EC50 value of the tannin compounds to PRRSV is lower than or obviously lower than that of ribavirin; therefore, the inhibiting effect of the compounds on the PRRSV is greater than or even far greater than that of a positive control drug ribavirin. The compounds have an unexpected effect of resisting PRRSV (porcine reproductive and respiratory syndrome virus).

The invention discloses a sialic acid molecular imprinting extraction method, and belongs to the technical field of separation and purification. The invention discloses a sialic acid molecular imprinting extraction method which comprises the following steps: dissolving a sialic acid standard substance and a functional monomer in a binary pore-foaming agent-ionic liquid, adding a cross-linking agent and an initiator, polymerizing under ultraviolet light to prepare a high-molecular polymer, and washing off the sialic acid standard substance to prepare a molecular imprinting polymer; specifically adsorbing sialic acid in the fermentation liquor by using the molecularly imprinted polymer; performing graded elution on sialic acid by using a methanol-water mixed solution and a methanol-acetic acid mixed solution; and performing rotary evaporation concentration, anti-solvent crystallization, separation and drying on the bird's nest acid eluent. Tests show that the sialic acid purity is greater than or equal to 99%, and can meet the requirements of the sialic acid in the fields of food, health care, medicine, cosmetics and the like. According to the method, sialic acid can be efficiently separated and extracted from sialic acid fermentation liquor, the product yield is increased, the extraction procedures are reduced, and the production cost and the discharge amount of three wastes are reduced.

The invention relates to the technical field of cleaning solutions, in particular to a turbine engine airway cleaning agent, a preparation method thereof and a cleaning solution, and the cleaning agent comprises the following components in percentage by mass: 6-10% of 2, 4, 7, 9-tetramethyl-5-decyne-4, 7-glycol polyoxyethylene ether, 3-5% of a multifunctional additive, 0.5-1% of a corrosion inhibitor and 84-90.5% of deionized water. According to the invention, the ash-free nonionic surfactant 2, 4, 7, 9-tetramethyl-5-decyne-4, 7-glycol polyoxyethylene ether has emulsification and permeation wetting functions, has emulsification and stripping functions on semi-solid oil sludge containing carbon deposition, and has a synergistic decontamination effect with the multifunctional auxiliary agent, and the multifunctional auxiliary agent contains an amide group, so that the multifunctional cleaning agent has a good cleaning effect on the semi-solid oil sludge containing carbon deposition. The metal corrosion inhibitor can be adsorbed on the metal surface or coordinated with metal ions on the metal surface to form a layer of isolating membrane to protect metal, has a synergistic effect with the corrosion inhibitor, only generates carbon dioxide, hydrogen nitride gas and water vapor after combustion, and does not contain ash such as inorganic salt or metal oxide.

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

The present invention provides methods for glycosylation and compound preparation. The compounds include galactosylated, sialylated, fucosylated, and N-acetylglucosaminated compounds from simple oligosaccharides and sugars of animal, plant, or microbial origin. In certain embodiments, the invention provides for trinucleotide-free enzymatic production of oligosaccharides starting from simple sugars, including plant-based sugars. The present invention also provides methods of enzymatic production of fucosylated oligosaccharides and fucosylated antibody-glycan conjugates from ordinary enzymes. The production may be a cell-free, one-pot synthesis using an enzyme and, in some embodiments, an immobilized enzyme. The synthesis is a highly customizable and efficient cell-free manufacturing process. In some embodiments, lactose derivatives and human milk oligosaccharides (HMOs) are produced.

The invention relates to the technical field of radiopharmaceutical chemistry and clinical nuclear medicine, in particular to preparation and application of isonitrile mannose cuprous complex salt derivatives. The structure of the isonitrile mannose cuprous complex salt derivative is shown in (I), the isonitrile mannose cuprous complex salt derivative is good in stability, a marking method is simple when a freeze-drying medicine box prepared from the isonitrile mannose cuprous complex salt derivative is used for preparing < 99m > Tc tumor marking radiopharmaceuticals, the marking rate of a final product is larger than 90%, the tumor affinity performance is good, and clinical application and popularization are convenient. # imgabs0 #

The present invention relates to the technical field of traditional Chinese medicine extraction and detection, and particularly relates to an extraction method for tannin fractions in fresh Terminalia chebula, an extraction and purification method for tannin compounds, and a detection method. The extraction method for tannin fractions in fresh Terminalia chebula provided by the present invention uses fresh Terminalia chebula fruits as raw materials, and successively performs stone removal, water-added juicing, and ultrasonic extraction, which can not only avoid the degradation of tannic acid, but also obtain an ideal extraction rate, and has a simple process, low energy consumption, and short time consumption. The present invention also provides an extraction and purification method for tannin compounds. Through macroporous adsorption resin elution, alcohol precipitation, octadecylsilyl reverse-phase packing column elution, and preparative chromatography separation, high-purity chebulic acid, gallic acid, 4-galloylshikimic acid, and 5-galloylshikimic acid can be obtained. The detection method provided by the present invention can detect more than ten tannin components, has high efficiency, and helps to provide data support for the in-depth study of tannin components in Terminalia chebula.

The present invention provides modified sophorolipids comprising taurine for improved foaming performance. The present invention also provides compositions comprising modified sophorolipids formulated for use in cosmetics and personal care products. Further provided are methods for improving the skin condition, enhancing and / or maintaining its oral health, and cleansing, enhancing and / or maintaining its healthy hair in a subject.

Provided herein are compounds comprising one or more lipophilic moieties and capable of being used to prepare one or more lipophilic monomers. Also provided herein are lipophilic monomers capable of being conjugated to one or more positions on at least one strand of an oligonucleotide, and oligonucleotides comprising at least one of the lipophilic monomers.

The present invention provides novel methods for the chromatographic analysis of glycans using high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier and a labeling reagent which is capapble of providing amphipathic and strongly basic labeling moieties to a sample to be analyzed.