11436results about "Group 5/15 element organic compounds" patented technology

The present disclosure provides compositions and methods for using fixed biological samples in partition-based assays. In at least one embodiment, the disclosure provides a composition comprising a fixed biological sample and an un-fixing agent contained in a partition, such as a discrete droplet. In some embodiments, the disclosure provides un-fixing agent compounds capable of catalytically cleaving crosslinks in fixed biological samples, particularly crosslinked nucleic acids, such as RNA.

The present disclosure provides compounds of formula (Vc) and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic protein.

Disclosed is a nitrogen-containing heterocyclic compound, pharmaceutical composition thereof and application thereof. The present disclosure provides a nitrogen-containing heterocyclic compound of formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof. The nitrogen-containing heterocyclic compounds as represented in Formula I in the present disclosure have good inhibitory effects on cells of various mutations such as KRAS G12C, KRAS G12D, KRAS G12V, KRAS Q61H and other mutations, as well as on KRAS-amplified wild-type cells, and are expected to treat and / or prevent a wide range of diseases associated with Ras.

A benzo nitrogen-containing heterocyclic derivative regulator, a preparation method therefor and a use thereof. Particularly, the present invention relates to a compound represented by general formula (XIX), a preparation method therefor, a pharmaceutical composition containing the compound, and a use of the compound as a regulator in the preparation of drugs for treating metabolic diseases and related diseases, wherein each substituent in the general formula (XIX) is the same as the definition in the description.

The invention provides novel tetracyclic compounds and derivatives thereof, and pharmaceutical compositions thereof and methods for treating diseases and disorders, such as various types of cancer.

The present application belongs to the field of medical chemistry, and relates to a fused tricyclic compound and the medical use thereof. The compound has a structure as represented by formula (I). Particularly, the present application further relates to a method for preparing the compound, a pharmaceutical composition of the compound and the use of the compound in the treatment of diseases.

The invention belongs to the technical field of perovskite solar cells, and particularly discloses a carbazolyl conjugate enhanced self-assembled monomolecular layer and a preparation method and application thereof, and the self-assembled monomolecular layer takes carbazole as a substrate and an aromatic ring as a conjugate linking group. The highly conjugated molecular system can induce molecular orbital overlap, increase dipole moment, promote formation of a compact self-assembled monomolecular film, reduce interface non-radiative recombination and enhance hole extraction and transmission performance. Meanwhile, phosphoric acid is used as an anchoring group, so that firm self-assembly of SAM molecules on the surface of the ITO substrate can be realized. The SAM material is simple in preparation method, high in yield, low in preparation cost and good in stability. When the compound is applied to a trans-perovskite solar cell as a hole transport layer, photoelectric conversion efficiency exceeding 24.6% can be obtained, and the compound is an organic semiconductor material with a very good prospect.

The invention relates to a phenyl-containing heterocyclic derivative regulator as well as a preparation method and application thereof. In particular, the present invention relates to a compound represented by general formula (XVI), a preparation method thereof, a pharmaceutical composition containing the compound, and an application of the compound as a regulator in the preparation of drugs for treating metabolic diseases and related diseases, each substituent in the general formula (XVI) being as defined in the specification # imgabs0 #

The invention belongs to the field of photovoltaic materials, and provides a self-assembly hole transport material and application thereof.The self-assembly hole transport material is a novel carbazole derivative and has a phosphonic acid anchoring group capable of achieving monomolecular layer self-assembly, meanwhile, hydrophilic groups containing aromatic rings are introduced to one sides of two benzene rings in carbazole, and therefore the hole transport efficiency is improved. Comprising methoxyphenyl, methylthiophenyl, cyanophenyl, formylaminophenyl or carboxyphenyl, can effectively improve the good wettability of a perovskite precursor solution on a self-assembled monomolecular layer, and can form a good complexing effect with a perovskite component, thereby achieving the purpose of passivating a lower interface of perovskite; meanwhile, the aromatic ring added in the added carbazole can regulate the energy level of the self-assembled micromolecules and the perovskite layer, so that the perovskite can be better matched, the charge transfer efficiency of the cell is optimized, and the effect of improving the conversion efficiency and stability of the perovskite cell is finally achieved.

The invention discloses a self-assembled monomolecular layer material with an asymmetric intermediate core and a preparation method and application thereof, and belongs to the field of solar cells. The self-assembled monomolecular layer material is formed by combining an asymmetric intermediate core with anchoring groups such as phosphonic acid and sulfonic acid, has good hydrophobicity and high light transmittance, can be used as a hole transport layer material, and is used for preparing organic solar cells and perovskite solar cells with p-i-n structures, the organic solar cell achieves the maximum energy conversion efficiency of 18.9%, shows excellent environmental stability, still keeps 95% or above of the initial performance after being stored in air for 480 h, and is far superior to a traditional device based on a PEDOT: PSS interface layer. By designing and developing a series of self-assembled monomolecular layer materials with asymmetric intermediate cores, the energy conversion efficiency and environmental stability of the solar cell can be remarkably improved.

The invention belongs to the technical field of perovskite solar cells, and particularly discloses a self-assembly monomolecular film hole transport material based on diphosphoric acid and a preparation method and application thereof.The diphosphoric acid serves as an anchoring group, the chelation between the material and a conductive base can be effectively enhanced, the self-assembly characteristic of the material on the surface of a substrate is improved, and the hole transport efficiency is improved. The compact and smooth self-assembled monomolecular film is formed. Meanwhile, the electron and space effects of alkyl chains or benzene ring connecting units are regulated and controlled, so that the molecular stereo configuration and energy level matching are optimized. The material disclosed by the invention is simple in synthesis steps and low in preparation cost, and industrial synthesis of the material can be realized. When the material is applied to an inverted perovskite solar cell as a hole transport layer, photoelectric conversion efficiency exceeding 24.7% and excellent device stability performance can be obtained, and huge commercial prospects are shown.

The present invention discloses a self-assembled monolayer hole transport material based on an alkyl polyphosphate anchoring group, a synthesis method thereof, and an application in an inverted perovskite solar cell. The present invention uses carbazole or 3,6-diphenylcarbazole with good hole transport properties as a parent core, and achieves complete coverage and stable self-assembly of the material on the substrate surface by improving the anchoring group from traditional alkyl monophosphate to alkyl diphosphate and triphosphate. The synthesis method of the present invention is simple and the synthesis cost is low. The prepared material can achieve the dual functions of hole transport and perovskite interface passivation, while enhancing the self-assembly strength and stability. When the material is used as a hole transport layer in an inverted perovskite solar cell, a photoelectric conversion efficiency of >20% can be obtained without doping, and the material has broad application prospects.

The invention discloses a self-assembled monomolecular layer hole transport material, a hole transport layer and a battery thereof. According to the present invention, the compound having different anchoring groups and represented by the formula (I) can be subjected to firm self-assembly with the substrate surface through the chemical bonding manner, such that the good coverage rate is provided, the film forming quality is increased, and the transmission performance is improved; and meanwhile, the material has a rigid conjugate large-plane condensed ring core structure, so that the hole transmission performance of the material is ensured, and the photovoltaic performance is favorably improved. When the material is applied to a perovskite solar cell to prepare a hole transport layer, the hole extraction capability can be enhanced, and the open-circuit voltage, the filling factor and the photoelectric conversion efficiency of a device can be improved.

The invention discloses a preparation method of a fluorine-containing carbazole phosphonic acid compound, which solves the technical problems of harsh reaction conditions, high raw material price and low yield in the existing preparation process, 4-trifluoromethoxyaniline and 4-trifluoromethoxyiodobenzene are used as initial raw materials, and Ullmann reaction is performed under a solvent-free condition to obtain 4, 4 '-difluorocarbazole phosphonic acid. The preparation method comprises the following steps: taking 3, 4 '-bis (trifluoromethoxy) diphenylamine as a raw material, carrying out palladium acetate catalytic oxidation cyclization to obtain 3, 6-bis (trifluoromethoxy) carbazole, reacting the 3, 6-bis (trifluoromethoxy) carbazole with 2-bromoethyl dimethyl phosphonate to obtain N-(2-ethyl dimethyl phosphonate) 3, 6-bis (trifluoromethoxy) carbazole, and finally hydrolyzing to obtain the N-(2-ethyl phosphonate) 3, 6-bis (trifluoromethoxy) carbazole. The reaction process is simpler to operate, the yield is guaranteed, and the method is suitable for large-scale production. In the preparation method disclosed by the invention, a solvent is not required to be used in multiple steps, the reaction is performed under a solvent-free condition, and the preparation method is high in safety and environment-friendly.

Provided herein are compounds of Formula I, or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R8, R9, X, Y, Z, W, and m are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula I or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipients, and methods of using the same, e.g., in the treatment of mental health diseases and / or disorders.

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

The application provides a process method for preparing (2-(3,6-dimethoxy-9H-carbazol-9-yl)ethyl) phosphonic acid, and particularly relates to the technical field of organic synthesis. The process method is that, under alkaline conditions, a halogenated phosphonate compound is added into a 3,6-dimethoxy-9H-carbazole solution to perform a reaction, hydrochloric acid aqueous solution is added after the reaction to perform acidolysis degreasing, and finally (2-(3,6-dimethoxy-9H-carbazol-9-yl)ethyl) phosphonic acid is obtained through extraction, reflux adsorption and beating purification. The process method uses 3,6-dimethoxy-9H-carbazole as a starting material, realizes the synthesis of the target product through one-pot reaction, has mild reaction conditions, uses non-toxic raw materials which are easy to obtain, has simple synthesis process, is convenient to operate, and has high separation yield.

The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

The invention relates to a high-temperature-resistant nylon engineering plastic and a preparation method thereof, and belongs to the technical field of high polymer materials. The high-temperature-resistant nylon engineering plastic comprises the following components in parts by weight: 80-120 parts of nylon resin, 4-6 parts of inorganic filler, 4-6 parts of glass fiber, 2-10 parts of a heat-resistant modifier, 1-2 parts of a coupling agent, 1-3 parts of polyethylene wax, 0.5-1.5 parts of an antioxidant and 1-2 parts of a flame retardant, carbonyl and maleimide groups of the heat-resistant modifier strengthen intermolecular interaction and improve the glass transition temperature and the melting point, intermediate products 1 and 2 strengthen high temperature resistance, in addition, sulfonyl attracts electrons to strengthen thermal stability, tetrahydrofuran ring and acrylate are resistant to decomposition, and stability and water resistance are improved; boron and nitrogen of the flame retardant cooperate, a B-O-C carbon layer is formed at high temperature, flame-retardant gas is released, the flame-retardant property is remarkably improved, and the high-temperature-resistant nylon engineering plastic prepared by the preparation method has good high-temperature-resistant and water-resistant effects and also has excellent flame-retardant property.

The invention relates to the technical field of medicines, in particular to a GLP-1 agonist as well as a preparation method and application thereof. The GLP-1 agonist has a structure as shown in a formula I, or a pharmaceutically acceptable salt or solvate thereof. The GLP-1 agonist provided by the invention has relatively high activity and bioavailability.

The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

The invention relates to the technical field of flame retardants, in particular to a phosphorus-nitrogen synergistic flame-retardant biomass flame retardant and application thereof. A conventional reaction type phosphorus-nitrogen flame retardant is huge in structure and large in steric hindrance and cannot be completely dissolved in an epoxy resin material system, the obtained flame-retardant epoxy resin is poor in transparency, and the mechanical property is greatly reduced. In order to solve the problems, the invention provides the phosphorus-nitrogen synergistic flame-retardant biomass flame retardant which is obtained by sequentially carrying out simple one-pot synthesis reaction on furfural and furfural derivatives with 2-amino-1, 3, 4-thiadiazole and DOPO, and the flame retardant is simple in structure, small in steric hindrance, easy to completely dissolve in epoxy resin, good in flame retardancy and good in flame retardance. The obtained flame-retardant epoxy resin is better in transparency, flame retardance and mechanical property.

The invention relates to the technical field of flame retardants, and discloses an enhanced ceramic zinc borate nano flame retardant and a preparation method thereof.The enhanced ceramic zinc borate nano flame retardant is obtained by adding ceramic zinc borate, a sulfur-containing flame retardant and sodium sulfonate modified silane into a stirrer and stirring. The enhanced ceramic zinc borate nano flame retardant is obtained by adding ceramic zinc borate, a sulfur-containing flame retardant and sodium sulfonate modified silane into a stirrer and stirring. Boron elements, sulfur elements, phosphorus elements, silicon elements and sodium sulfonate groups in the sulfur-containing flame retardant and the sodium sulfonate modified silane jointly form a flame-retardant system, and synergistic flame retardance is achieved.

Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer, or salt thereof, wherein R1, R2, R3, R4, R5, L1a, L1b, L2, L3, L4, L5, L6, L7, M1, M2, q, w, m and n are as defined herein. Compounds of structure (I) find utility in a number of applications, including use as therapeutic agents for various treatment methods.

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat neurocognitive disorders (e.g., Alzheimer's disease, Parkinson's disease), ADHD, Epilepsy, Autism, Sleep-wake disorders, Chronic pain, Inflammatory Disorders, IBD, Stroke, ALS, and / or Multiple Sclerosis.