285 results about "Acid salt" patented technology

The present invention relates to a free base crystal form of a nitrogen-containing heterocyclic derivative, an acid salt and a crystal form thereof, a preparation method therefor, and a use thereof. In particular, the present invention relates to a free base crystal form of a compound represented by a general formula, an acid salt and a crystal form thereof, a preparation method therefor, a pharmaceutical composition containing a therapeutically effective amount of the salt or crystal form, and a use thereof as an inhibitor in the treatment of diseases such as cardiovascular disease and cerebrovascular disease.

Mobile or stationary air filter (L) or room fan (RL) according to Figure 1, comprising an outer wall (5), a (2) for generating an airflow (3) which is guided through an air filter material (1.1), an air inlet (2.1) and an air outlet (2.2), wherein the air filter material (1.1) contains poly(styrenesulfonic acid) (sulfonic acid biocide) (1.3) cross-linked with divinylbenzene and / or an acidic salt (1.3.1) (sulfonic acid biocide salt) of the sulfonic acid biocide (1.3) with biocidal cations, wherein the sulfonic acid biocide (1.3) and / or sulfonic acid biocide salt (1.3.1)(i) are positively and / or materially bonded to and / or in inert carriers and, in the fixed state, are in direct contact with carrier materials (1.1.7) on and / or in which biocidal Metal microparticles of a mean particle size d50 of 0.1 µm to <1,000 µm are fixed, and / or (ii) with carrier materials (1.1.7) on and / or in which biocidal metal microparticles of a mean particle size d50 of 0.1 µm to <1.000 µm are fixed, are mixed; its use and methods for the production and environmentally friendly disposal of air filter materials (1.1).

The invention discloses a fluid inclusion standard sample for in-situ isotope analysis as well as preparation and application of the fluid inclusion standard sample. The preparation method comprises the following steps: obtaining silicate glass powder with uniform components, carrying out high-temperature and high-pressure reaction on the glass powder and a fluid salt solution with the same mass in a closed Cu-Au tube, taking out a reaction product after the reaction, and drying to obtain the fluid inclusion standard sample for isotope analysis. According to the method, the silicate glass with uniform components can rapidly capture the fluid inclusion, and the Cu isotope in the fluid inclusion is accurately measured and controlled according to the fractionation degree of the Cu isotope between the acid salt melt and the fluid.

The invention relates to a nanofiltration membrane and a preparation method thereof. The nanofiltration membrane sequentially comprises a supporting material and a membrane body from bottom to top, the base film is formed by a base film solution containing a polymer with a polyimide structure, a nano material and a silane coupling agent containing at least one functional group of a primary amino group, a secondary amino group and an epoxy group; the functional layer is formed by treating a prepolymer of aliphatic polyamine and aromatic polyisocyanate with more than three isocyanate groups with an aqueous solution containing hyperbranched polyamine and strong alkali and weak acid salt; the molar amount of the aromatic polyisocyanate having more than three isocyanate groups is excessive relative to the molar amount of the aliphatic polyamine, the prepolymer has unreacted isocyanate groups, the prepolymer is prepared at a temperature range of 10-20 DEG C, and the treatment is carried out at a temperature range of 50-80 DEG C. The nanofiltration membrane can tolerate a temperature of 70 DEG C or above and a high-concentration alkali of 20 wt% or above, and has excellent salt rejection rate and flux.

The invention provides a current collector modified by a self-repairing polymer coating, a preparation method and application of the current collector, and a negative-electrode-free sodium ion battery, and relates to the technical field of batteries. The preparation method of the current collector modified by the self-repairing polymer coating comprises the following steps: adding strong alkali and weak acid salt of NaOH or Na into an aqueous solution of polyacrylic acid, adjusting the pH to be neutral, then adding a plasticizer and a conductive agent to prepare slurry, then coating the surface of a base material with the slurry, drying and curing the base material, soaking the base material in a NaCl solution, and drying the base material to obtain the current collector modified by the self-repairing polymer coating. And after soaking is finished, the current collector modified by the self-repairing polymer coating is prepared. When the current collector is used for the negative-electrode-free sodium ion battery, coating loss caused by volume expansion in the dendritic crystal and sodium deposition / stripping process can be spontaneously repaired through Na < + > migration, the safety risk is reduced, and long-term stable operation of the negative-electrode-free sodium ion battery is guaranteed.

The invention discloses a preparation method of an anti-aging lead-acid battery electrolyte, and relates to the technical field of electrolytes. According to the electrolyte, dilute sulphuric acid is adopted as a basic system, and a biological small molecule synergistic inhibitor (sodium glutamate and taurine), organic weak acid salt (triammonium citrate), water-soluble polymer (hydroxypropyl methyl cellulose), a conductive nano material (graphene oxide) and a green deep eutectic solvent (choline chloride-ethylene glycol) are compositely introduced; and a trace amount of aluminum salt and a metal organic catalyst are supplemented. By inhibiting sulfation, relieving grid corrosion, inhibiting gassing and balancing acid concentration, systematic improvement of the cycle life, the charge acceptance and the repair capacity of the lead-acid battery is realized.

The present invention relates to new salt forms of sabcomeline. The new salt forms are lipophilic acid salts of sabcomeline wherein the lipophilic acids used to prepare the new salts may have a Hansen solubility parameter distance from water of at least 20.7. The present invention also relates to new crystalline forms of sabocomeline salts.

The invention belongs to the technical field of synthetic high polymer materials, and relates to water-soluble polyamide acid salt as well as a water-phase one-pot preparation method and application thereof. The preparation method comprises the following steps: completely dissolving an aromatic dianhydride monomer in water to obtain a first solution, completely dissolving an aromatic diamine monomer and an organic alkali in water to obtain a second solution, mixing the first solution and the second solution, carrying out a polymerization reaction, after the polymerization reaction is finished, adding an end-capping reagent, continuously stirring until the end-capping reagent is completely dissolved, and removing water to obtain a finished product. The water-soluble polyamide acid salt is obtained. According to the preparation method, water is used as a solvent, a single-step polymerization reaction is adopted, any subsequent purification treatment step is not needed, the production process is green and environment-friendly, the process is simple and convenient, the cost is low, and the preparation method is not limited by the feeding amount of aromatic dianhydride monomers and the scale of a reaction system. The viscosity average molecular weight of the finally prepared water-soluble polyamide acid salt is 8.0 * 10 < 3 >-2.0 * 10 < 4 > g / mol, the film forming effect is excellent, and the water-soluble polyamide acid salt can be used as sizing liquid.

The invention relates to a synthesis method of milobalin or acid salt thereof, and belongs to the technical field of medicine synthesis. In order to solve the problem that chiral resolution needs to be adopted in the prior art, the invention provides a synthesis method of miloabalin or an acid salt thereof, which comprises the following steps: under the action of an organic strong base, carrying out Michael addition reaction on a compound shown as a formula III and acetonitrile in a non-polar organic solvent at a low temperature of-50 DEG C or below to obtain an intermediate product; under the alkaline condition, the intermediate product is subjected to an oxidation reaction and a hydrolysis reaction under the action of an oxidizing agent, after the reaction is finished, an intermediate product is obtained through acidification, and the intermediate product is subjected to a high-temperature decarboxylation reaction in an aprotic solvent to obtain a compound of a formula VI; and carrying out Hofmann degradation reaction on the compound of formula VI to obtain the compound of formula I miloabalin or miloabalin acid salt. The method has the advantages of high stereoselectivity, no need of chiral resolution operation, avoidance of the problem of large material loss caused by resolution, high chiral purity and high yield.

The present invention relates to a method for producing p-xylylenedicamphor sulfonic acid, and more specifically, to a method for producing p-xylylenedicamphor sulfonic acid from p-xylylenedicamphor sulfonate through a step of producing a p-xylylenedicamphor sulfonyl intermediate compound. The method for producing p-xylylene dichorsulfonic acid according to the present invention is performed by a synthesis reaction and thus theoretically has a conversion rate of 100% from a salt to an acid. According to the method, the problems in the prior art are solved, so that ion exchange resin does not need to be used, the cost of using the ion exchange resin is reduced, and acidic waste generated in the regeneration process of the ion exchange resin is not generated. In addition, the method has the advantages of excellent yield and mass production.

The present invention relates to the technical field of starch ether synthesis, and discloses a hydroxypropyl starch ether synthesis method, which comprises: mixing an acid and / or an acid salt, a reaction solvent and propylene oxide, and carrying out a ring-opening reaction to obtain a pretreatment liquid; and mixing the pretreatment liquid with starch, carrying out etherification reaction, and separating out a product to obtain the hydroxypropyl starch ether. According to the present invention, the ring-opening reaction is performed on the epoxypropane by using the acid and / or the acid salt, and then the epoxypropane and the starch are subjected to the etherification reaction, such that the etherification reaction efficiency (RE value) can be improved, the production cost can be easily reduced, and the etherification reaction time can be shortened so as to improve the hydroxypropyl starch ether production efficiency, reduce the epoxypropane volatilization, and reduce the potential safety hazard.

The invention relates to a talcum powder filled polypropylene composite material based on surface modification and process cooperation and an injection molding pocking mark defect inhibition method. The material is composed of co-polypropylene, acidic salt-titanate composite modified talcum powder, flaky mica (5-10 [mu] m), a POE flexibilizer, a zeolite molecular sieve, an MAH-g-PP compatilizer, a zinc stearate dispersant and the like. According to the invention, the three measures of surface modification treatment, formula design and process purification technology are combined, and the problem of pitting defects (surface pits and white spots) generated in the injection molding process of the talcum powder filled polypropylene composite material is mainly solved. Through filler surface modification treatment, formula design and a process purification technology, the hard spot defect rate is reduced by about 85%, and the method is suitable for products with high surface quality requirements, such as automobile bumpers and instrument panels.

The invention relates to the technical field of building materials, and particularly discloses coal gangue doped cement and a preparation process thereof. The coal gangue doped cement is prepared from the following raw materials in parts by mass: 20-30 parts of activated coal gangue powder, 50-60 parts of cement clinker, 15-20 parts of slag powder, 1.5-2.5 parts of nano calcium carbonate, 0.8-1.5 parts of calcium sulphoaluminate, 3-5 parts of a composite curing agent, 4-9 parts of a composite exciting agent, 3-5 parts of water glass and 0.5-1 part of a water reducing agent, the activated coal gangue powder is prepared through urea pretreatment, segmented calcination and acid salt activation; the composite curing agent comprises silica fume and organic acid; the composite exciting agent comprises gypsum and triethanolamine. The coal gangue doped cement prepared by the invention has relatively excellent compressive strength and breaking strength.

The invention relates to a method for sealing a substrate, comprising at least steps 1) and 3), by applying at least part of a solvent-based composition to a surface of the substrate to at least part form a film (1) on said surface, applying at least part of a sealant composition to the film obtained after step 1) to form a sealant film (3), wherein the sealant composition is obtainable by mixing at least two components A) and B) of a sealing system, which are present separately, with one another, the solvent-borne composition applied in step 1) comprising at least one aliphatic hydrocarbon as an organic solvent component a1) in an amount of at least 70.0 wt.-%, based on the total weight of the composition, at least one organometallate as component a2) in an amount of at least 70.0 wt.-%, based on the total weight of the composition, the present invention relates to a method for preparing a solvent-borne composition comprising at least one metal acid salt, the metal of which is selected from Ti and Zr, and at least one organosilane as component a3), sealing substrates obtainable by this method, the use of this solvent-borne composition as an adhesion promoting composition, the solvent-borne composition itself, and a kit comprising said solvent-borne composition.

The present invention provides an acid salt of a Sigma-1 receptor agonist or a crystal form thereof, and a preparation method and application thereof. Specifically, it relates to an acid salt of 5-((2-(cyclopropylmethyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)(isopropyl)amino)-1-methylpyridin-2(1H)-one having high affinity for the sigma-1 receptor and a crystal form thereof. The present invention relates to a preparation method of the acid salt and the crystal form and its application in the pharmaceutical field. The acid salt of the compound 5-((2-(cyclopropylmethyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)(isopropyl)amino)-1-methylpyridin-2(1H)-one and the crystal form thereof provided by the present invention have improved physical and chemical properties, such as appearance, hygroscopicity and chemical stability.

The invention relates to a crystal form of a sulfoximine compound as well as a preparation method and application of the crystal form. Specifically, the invention discloses a crystal form of a compound as shown in formula (I) and a preparation method and application thereof, and the crystal form has excellent stability and can be widely applied to preparation of drugs for preventing and / or treating diseases related to increase of activity and expression quantity of FGFR2 (Fibroblast Growth Factor Receptor 2). The preferable crystal form of the # imgabs0 is a hydrochloride crystal form I of a compound shown in a formula I, and an X-ray powder diffraction pattern of the hydrochloride crystal form I has a 2 theta angle selected from the following groups: 6.68 + / -0.2 degrees, 13.34 + / -0.2 degrees and 21.42 + / -0.2 degrees.

This invention discloses a method for preparing and analyzing trans-4-aminocyclohexylacetic acid. The preparation method is as follows: 4-nitrophenylacetic acid undergoes catalytic hydrogenation in a solvent, followed by filtration. The filtrate is then treated with acid to obtain a 4-aminophenylacetic acid salt solution. The collected catalyst is activated. The 4-aminophenylacetic acid salt solution is mixed with isopropanol, barium hydroxide, tetrabutylammonium bromide, 18-crown ether-6, and dibutyl phthalate. The activated catalyst is then added to initiate a catalytic hydrogenation reaction. After the reaction, the reaction solution is cooled and filtered. The resulting solid is mixed with a preheated dilute sulfuric acid solution and stirred to form a slurry. The mixture is then filtered, and the filtrate is neutralized and filtered again. The collected filtrate is concentrated and crystallized. The crystallized precipitate is washed and dried to obtain trans-4-aminocyclohexylacetic acid. The method provided by this invention has high reaction efficiency, mild conditions, and is suitable for industrial production. It yields high product purity and reliability. Furthermore, the analytical method provided by this invention is accurate and reliable.

The present invention provides a water-based surface preparation agent composition that combines paint film stripping and rust removal properties. [Solution] This is a surface preparation agent composition for removing rust along with the existing paint film when repainting an existing paint film applied to existing steel materials. It contains at least benzyl alcohol, a hydroxy acid, and water. The hydroxy acid is citric acid, malic acid, or an acidic salt thereof. Furthermore, it contains hydroxyethyl cellulose as an emulsifier for benzyl alcohol. The pH is preferably 4.0 to 6.0. This water-based surface preparation agent composition is applied to the existing steel material to remove rust along with the existing paint film.

The present application relates to a kind of based on Pickering emulsion method preparation heat-conducting filler-polyimide core-shell microspheres method, the method includes the following steps: aromatic diamine monomer is added with aromatic dianhydride monomer and organic polar solvent into reaction vessel and is reacted;Deposition in water, crush, wash and dry, to obtain polyamide acid salt precursor powder;Then with triethylamine and water stirring reaction, to obtain aqueous phase;Heat-conducting filler and hydrophobic polymer are dispersed in solvent to obtain oil phase;Oil phase and aqueous phase are mixed and emulsified, to obtain water-in-oil Pickering emulsion;Demulsification in precipitator, dry, to obtain heat-conducting filler-polyimide core-shell structure microspheres.The present application also provides the heat-conducting filler-polyimide core-shell microspheres prepared by the method, the method for preparing polyimide-based heat-conducting composite material using the core-shell microspheres and the composite material obtained therefrom.The present application method can efficiently prepare three-dimensional heat-conducting composite material with high thermal conductivity in horizontal and vertical directions.

The present invention provides a functional composition, a battery separator comprising the same, and a preparation method. In terms of mass percentage, the functional composition comprises 60-80% of an insulating resin and 5-15% of an ion-conducting resin; the insulating resin comprises an imide polymer; the molecular chain of the imide polymer contains an aliphatic structural unit and a functional group; the ion-conducting resin comprises at least one of polyamic acid salt, polyimide-amide acid salt or polyacrylonitrile-acrylate. In the present invention, the functional composition is compounded with insulating resin and ion-conducting resin of specific contents and types, so that the separator comprising the functional composition has excellent breakdown strength, good ion transportability and good adhesion to the electrode tab, can improve the structural stability of the separator, reduce the risk of battery short circuit, and improve the use safety of the battery separator.

The invention relates to an acid salt of a compound shown as a formula (I), in particular to a hydrochloride of the compound shown as a crystalline form (I) and a preparation method and application of the hydrochloride, and the compound is a PD-1 / PD-L1 inhibitor with the structure of the compound shown as the formula (I). The acid salt of the compound as shown in the formula (I) has improved dissolving capacity in a biological medium, and particularly, the crystalline compound hydrochloride has moderate hygroscopicity, good crystallinity, good solubility and stable physicochemical properties, which all meet the industrial production requirements and meet the development requirements of clinical pharmaceutical preparations. The acid salt or crystalline compound hydrochloride of the compound shown in the formula (I) can be widely applied to preparation of drugs for treating PD-1 / PD-L1 signal channel mediated tumors, immune related diseases and disorders, infectious diseases, infectious diseases or metabolic diseases.

The application discloses a phosphate-based dry film lubricating coating and preparation and application thereof. The coating is obtained by curing components with the following mass fractions, wherein the components consist of the following ingredients: phosphate binder 15-18 parts, sulfide 3-5 parts, silver powder 4-6 parts, oxygen-containing acid salt 1.5-3.5 parts, and metal oxide 0.2-0.32 parts, antioxidant 0.6-1.2 parts, and surfactant 0.1-0.2 parts, and the rest is solvent. The application solves the problems of weak adhesion between the existing coating and the substrate, wide temperature range lubrication from room temperature to 800 DEG C, large friction coefficient, short wear life and high cost. The coating has good adhesion to the substrate material, excellent flexibility and impact resistance, is environment-friendly, low-cost and has excellent friction-reducing and wear-resisting performance, has a low friction coefficient from room temperature to 800 DEG C, especially a friction coefficient < 0.16 at 800 DEG C, and has a long wear life.

Provided is a method for preparing a liposomal composition. The method comprises the step of contacting a liposome solution with a mild acidic agent for a limited time. The liposome solution comprises a weak acid salt encapsulated within an aqueous interior space separated from the aqueous medium by a membrane comprised of a lipid mixture containing one or more lipids and a hydrophilic polymer conjugated lipid at a molar percentage of less than 3% based on the total amount of the lipid mixture. The time for encapsulating the agent to a desired amount at a predetermined ratio to lipids is dramatically reduced even under a condition without elevating the temperature to above ambient environment.

The present invention provides: a composition with which the surface of a stainless steel is sufficiently roughened in an efficient manner with few steps; a method for roughening a stainless steel; and the like. The above are achieved by means of a composition for roughening the surface of a stainless steel, said composition containing from 0.1% by mass to 25% by mass of one or more substances that are selected from the group consisting of persulfuric acid and persulfuric acid salts based on the total amount of the composition, and from 1% by mass to 30% by mass of halide ions based on the total amount of the composition.

A lubricating oil additive composition including: (i) a Broensted acid salt of at least one first amide compound, the Broensted acid salt being a salt of the first amide compound and a Broensted acid, the first amide compound being a monoamide of at least one fatty acid (a1), and at least one amine compound (a2), the amine compound (a2) being an oligomer of at least one alkanolamine (a3) represented by the general formula (1):in the formula, n is 1 or 2; R1 is C1-4 linear chain alkylene or C3-10 branched chain alkylene, the C3-10 branched chain alkylene having a main chain, the main chain having a carbon number of 2; and when n is 2, a plurality of R1's may be the same, and may be different from each other.

The invention relates to a biosynthesis method of pyridoxal phosphate or pyridoxine phosphate, and belongs to the technical field of biosynthesis. In order to solve the existing problem of serious environmental pollution, the invention provides a biosynthesis method of pyridoxal phosphate or pyridoxine phosphate, which comprises the following steps: in the presence of polyphosphate, magnesium salt, ATP (adenosine triphosphate), pyridoxal kinase and polyphosphate kinase, performing phosphorylation reaction on pyridoxal or pyridoxine and acid salts thereof, thereby obtaining the pyridoxal phosphate or pyridoxine phosphate. The temperature of the phosphorylation reaction is controlled to be 30-38 DEG C, after the reaction is finished, protein separation is conducted on reaction liquid, mother liquor is separated, the compound pyridoxal phosphate or pyridoxine phosphate shown in the formula I is obtained, and the mother liquor is recycled and reused. According to the method, a large amount of ammonium acetophosphate does not need to be additionally added, operation is simpler, mother liquor can be recycled, a large amount of waste water is prevented from being discharged, environment friendliness is better achieved, and the yield is high.

The invention belongs to the technical field of nylon 66 polymer performance testing, and particularly relates to a method for simultaneously testing the content of iodide ions and bromide ions in a nylon 66 polymer, which comprises the following steps of: extracting the iodide ions and the bromide ions in the polymer by using weak acid salt (sub-carbonate or bicarbonate) instead of potassium nitrate as an ionic strength regulator; the acid environment in the extracted solution is adjusted with formic acid, silver nitrate is adopted as a titrant, iodide ions and bromide ions in the extract liquor are detected at the same time through potentiometric titration, and the problem that the iodide ions and the bromide ions cannot be detected at the same time is solved.

The invention discloses a determination method for a dissolution curve of a citrus flavone tablet, and belongs to the technical field of pharmaceutical analysis. The method comprises the following steps: setting dissolution conditions, and preparing a dissolution medium which is a strong alkali solution with the mass volume ratio of 0.1-0.6% or a strong alkali and weak acid salt solution with the mass volume ratio of 1-2% and a Tween 80 solution with the mass volume ratio of 1-2%; the method comprises the following steps: setting liquid chromatography detection conditions, and adopting a Phenomenex Gemini chromatographic column; preparing a test solution and a reference solution; and finally, detecting the contents of diosmin and hesperidin in each solution according to a liquid chromatography to obtain dissolution rates at different time, and establishing a dissolution curve according to the dissolution rates and the dissolution time. The method has the advantages of scientificity, durability and reproducibility, the measured dissolution curve has distinguishing power, the in-vitro release behavior of the dissolution curve can be evaluated, guarantee is provided for quality consistency between batches of drugs, the method can also be used for quality consistency evaluation work of imitated drugs and originally developed preparations, and the medication curative effect is guaranteed.

The invention relates to the technical field of metal surface protection materials, in particular to a composite antirust agent with mildew-proof and antirust performance and a preparation method thereof.The preparation method comprises the following steps that S1, 5-nitroisophthalic acid and metal oxide are subjected to a heating reaction, and a reaction mixture containing 5-nitroisophthalic acid salt is generated; s2, carrying out separation and purification; s3, drying treatment is carried out, and dry powder is obtained; s4, premixing with a mildew inhibitor, a corrosion inhibitor, an antioxidant and a silane coupling agent to obtain uniform composite powder; and S5, mixing the composite powder, a surfactant and an organic solvent to obtain a composite antirust agent finished product. According to the invention, a composite system composed of 5-nitroisophthalic acid zinc and a plurality of functional auxiliary agents is constructed, so that synchronous mildew-proof and rust-proof protection on the metal surface in a high-humidity environment and an environment where microorganisms are easy to breed is realized, and the coating stability and the long-term protection reliability are remarkably improved.