218 results about "Acid salt" patented technology

The present invention relates to a free base crystal form of a nitrogen-containing heterocyclic derivative, an acid salt and a crystal form thereof, a preparation method therefor, and a use thereof. In particular, the present invention relates to a free base crystal form of a compound represented by a general formula, an acid salt and a crystal form thereof, a preparation method therefor, a pharmaceutical composition containing a therapeutically effective amount of the salt or crystal form, and a use thereof as an inhibitor in the treatment of diseases such as cardiovascular disease and cerebrovascular disease.

Mobile or stationary air filter (L) or room fan (RL) according to Figure 1, comprising an outer wall (5), a (2) for generating an airflow (3) which is guided through an air filter material (1.1), an air inlet (2.1) and an air outlet (2.2), wherein the air filter material (1.1) contains poly(styrenesulfonic acid) (sulfonic acid biocide) (1.3) cross-linked with divinylbenzene and / or an acidic salt (1.3.1) (sulfonic acid biocide salt) of the sulfonic acid biocide (1.3) with biocidal cations, wherein the sulfonic acid biocide (1.3) and / or sulfonic acid biocide salt (1.3.1)(i) are positively and / or materially bonded to and / or in inert carriers and, in the fixed state, are in direct contact with carrier materials (1.1.7) on and / or in which biocidal Metal microparticles of a mean particle size d50 of 0.1 µm to <1,000 µm are fixed, and / or (ii) with carrier materials (1.1.7) on and / or in which biocidal metal microparticles of a mean particle size d50 of 0.1 µm to <1.000 µm are fixed, are mixed; its use and methods for the production and environmentally friendly disposal of air filter materials (1.1).

The present invention relates to new salt forms of sabcomeline. The new salt forms are lipophilic acid salts of sabcomeline wherein the lipophilic acids used to prepare the new salts may have a Hansen solubility parameter distance from water of at least 20.7. The present invention also relates to new crystalline forms of sabocomeline salts.

The invention relates to a synthesis method of milobalin or acid salt thereof, and belongs to the technical field of medicine synthesis. In order to solve the problem that chiral resolution needs to be adopted in the prior art, the invention provides a synthesis method of miloabalin or an acid salt thereof, which comprises the following steps: under the action of an organic strong base, carrying out Michael addition reaction on a compound shown as a formula III and acetonitrile in a non-polar organic solvent at a low temperature of-50 DEG C or below to obtain an intermediate product; under the alkaline condition, the intermediate product is subjected to an oxidation reaction and a hydrolysis reaction under the action of an oxidizing agent, after the reaction is finished, an intermediate product is obtained through acidification, and the intermediate product is subjected to a high-temperature decarboxylation reaction in an aprotic solvent to obtain a compound of a formula VI; and carrying out Hofmann degradation reaction on the compound of formula VI to obtain the compound of formula I miloabalin or miloabalin acid salt. The method has the advantages of high stereoselectivity, no need of chiral resolution operation, avoidance of the problem of large material loss caused by resolution, high chiral purity and high yield.

The present invention relates to a method for producing p-xylylenedicamphor sulfonic acid, and more specifically, to a method for producing p-xylylenedicamphor sulfonic acid from p-xylylenedicamphor sulfonate through a step of producing a p-xylylenedicamphor sulfonyl intermediate compound. The method for producing p-xylylene dichorsulfonic acid according to the present invention is performed by a synthesis reaction and thus theoretically has a conversion rate of 100% from a salt to an acid. According to the method, the problems in the prior art are solved, so that ion exchange resin does not need to be used, the cost of using the ion exchange resin is reduced, and acidic waste generated in the regeneration process of the ion exchange resin is not generated. In addition, the method has the advantages of excellent yield and mass production.

The invention relates to a talcum powder filled polypropylene composite material based on surface modification and process cooperation and an injection molding pocking mark defect inhibition method. The material is composed of co-polypropylene, acidic salt-titanate composite modified talcum powder, flaky mica (5-10 [mu] m), a POE flexibilizer, a zeolite molecular sieve, an MAH-g-PP compatilizer, a zinc stearate dispersant and the like. According to the invention, the three measures of surface modification treatment, formula design and process purification technology are combined, and the problem of pitting defects (surface pits and white spots) generated in the injection molding process of the talcum powder filled polypropylene composite material is mainly solved. Through filler surface modification treatment, formula design and a process purification technology, the hard spot defect rate is reduced by about 85%, and the method is suitable for products with high surface quality requirements, such as automobile bumpers and instrument panels.

The invention relates to a method for sealing a substrate, comprising at least steps 1) and 3), by applying at least part of a solvent-based composition to a surface of the substrate to at least part form a film (1) on said surface, applying at least part of a sealant composition to the film obtained after step 1) to form a sealant film (3), wherein the sealant composition is obtainable by mixing at least two components A) and B) of a sealing system, which are present separately, with one another, the solvent-borne composition applied in step 1) comprising at least one aliphatic hydrocarbon as an organic solvent component a1) in an amount of at least 70.0 wt.-%, based on the total weight of the composition, at least one organometallate as component a2) in an amount of at least 70.0 wt.-%, based on the total weight of the composition, the present invention relates to a method for preparing a solvent-borne composition comprising at least one metal acid salt, the metal of which is selected from Ti and Zr, and at least one organosilane as component a3), sealing substrates obtainable by this method, the use of this solvent-borne composition as an adhesion promoting composition, the solvent-borne composition itself, and a kit comprising said solvent-borne composition.

This invention discloses a method for preparing and analyzing trans-4-aminocyclohexylacetic acid. The preparation method is as follows: 4-nitrophenylacetic acid undergoes catalytic hydrogenation in a solvent, followed by filtration. The filtrate is then treated with acid to obtain a 4-aminophenylacetic acid salt solution. The collected catalyst is activated. The 4-aminophenylacetic acid salt solution is mixed with isopropanol, barium hydroxide, tetrabutylammonium bromide, 18-crown ether-6, and dibutyl phthalate. The activated catalyst is then added to initiate a catalytic hydrogenation reaction. After the reaction, the reaction solution is cooled and filtered. The resulting solid is mixed with a preheated dilute sulfuric acid solution and stirred to form a slurry. The mixture is then filtered, and the filtrate is neutralized and filtered again. The collected filtrate is concentrated and crystallized. The crystallized precipitate is washed and dried to obtain trans-4-aminocyclohexylacetic acid. The method provided by this invention has high reaction efficiency, mild conditions, and is suitable for industrial production. It yields high product purity and reliability. Furthermore, the analytical method provided by this invention is accurate and reliable.

The present invention provides a water-based surface preparation agent composition that combines paint film stripping and rust removal properties. [Solution] This is a surface preparation agent composition for removing rust along with the existing paint film when repainting an existing paint film applied to existing steel materials. It contains at least benzyl alcohol, a hydroxy acid, and water. The hydroxy acid is citric acid, malic acid, or an acidic salt thereof. Furthermore, it contains hydroxyethyl cellulose as an emulsifier for benzyl alcohol. The pH is preferably 4.0 to 6.0. This water-based surface preparation agent composition is applied to the existing steel material to remove rust along with the existing paint film.

The present application relates to a kind of based on Pickering emulsion method preparation heat-conducting filler-polyimide core-shell microspheres method, the method includes the following steps: aromatic diamine monomer is added with aromatic dianhydride monomer and organic polar solvent into reaction vessel and is reacted;Deposition in water, crush, wash and dry, to obtain polyamide acid salt precursor powder;Then with triethylamine and water stirring reaction, to obtain aqueous phase;Heat-conducting filler and hydrophobic polymer are dispersed in solvent to obtain oil phase;Oil phase and aqueous phase are mixed and emulsified, to obtain water-in-oil Pickering emulsion;Demulsification in precipitator, dry, to obtain heat-conducting filler-polyimide core-shell structure microspheres.The present application also provides the heat-conducting filler-polyimide core-shell microspheres prepared by the method, the method for preparing polyimide-based heat-conducting composite material using the core-shell microspheres and the composite material obtained therefrom.The present application method can efficiently prepare three-dimensional heat-conducting composite material with high thermal conductivity in horizontal and vertical directions.

The invention relates to an acid salt of a compound shown as a formula (I), in particular to a hydrochloride of the compound shown as a crystalline form (I) and a preparation method and application of the hydrochloride, and the compound is a PD-1 / PD-L1 inhibitor with the structure of the compound shown as the formula (I). The acid salt of the compound as shown in the formula (I) has improved dissolving capacity in a biological medium, and particularly, the crystalline compound hydrochloride has moderate hygroscopicity, good crystallinity, good solubility and stable physicochemical properties, which all meet the industrial production requirements and meet the development requirements of clinical pharmaceutical preparations. The acid salt or crystalline compound hydrochloride of the compound shown in the formula (I) can be widely applied to preparation of drugs for treating PD-1 / PD-L1 signal channel mediated tumors, immune related diseases and disorders, infectious diseases, infectious diseases or metabolic diseases.

The application discloses a phosphate-based dry film lubricating coating and preparation and application thereof. The coating is obtained by curing components with the following mass fractions, wherein the components consist of the following ingredients: phosphate binder 15-18 parts, sulfide 3-5 parts, silver powder 4-6 parts, oxygen-containing acid salt 1.5-3.5 parts, and metal oxide 0.2-0.32 parts, antioxidant 0.6-1.2 parts, and surfactant 0.1-0.2 parts, and the rest is solvent. The application solves the problems of weak adhesion between the existing coating and the substrate, wide temperature range lubrication from room temperature to 800 DEG C, large friction coefficient, short wear life and high cost. The coating has good adhesion to the substrate material, excellent flexibility and impact resistance, is environment-friendly, low-cost and has excellent friction-reducing and wear-resisting performance, has a low friction coefficient from room temperature to 800 DEG C, especially a friction coefficient < 0.16 at 800 DEG C, and has a long wear life.

Provided is a method for preparing a liposomal composition. The method comprises the step of contacting a liposome solution with a mild acidic agent for a limited time. The liposome solution comprises a weak acid salt encapsulated within an aqueous interior space separated from the aqueous medium by a membrane comprised of a lipid mixture containing one or more lipids and a hydrophilic polymer conjugated lipid at a molar percentage of less than 3% based on the total amount of the lipid mixture. The time for encapsulating the agent to a desired amount at a predetermined ratio to lipids is dramatically reduced even under a condition without elevating the temperature to above ambient environment.

A lubricating oil additive composition including: (i) a Broensted acid salt of at least one first amide compound, the Broensted acid salt being a salt of the first amide compound and a Broensted acid, the first amide compound being a monoamide of at least one fatty acid (a1), and at least one amine compound (a2), the amine compound (a2) being an oligomer of at least one alkanolamine (a3) represented by the general formula (1):in the formula, n is 1 or 2; R1 is C1-4 linear chain alkylene or C3-10 branched chain alkylene, the C3-10 branched chain alkylene having a main chain, the main chain having a carbon number of 2; and when n is 2, a plurality of R1's may be the same, and may be different from each other.

The invention relates to a biosynthesis method of pyridoxal phosphate or pyridoxine phosphate, and belongs to the technical field of biosynthesis. In order to solve the existing problem of serious environmental pollution, the invention provides a biosynthesis method of pyridoxal phosphate or pyridoxine phosphate, which comprises the following steps: in the presence of polyphosphate, magnesium salt, ATP (adenosine triphosphate), pyridoxal kinase and polyphosphate kinase, performing phosphorylation reaction on pyridoxal or pyridoxine and acid salts thereof, thereby obtaining the pyridoxal phosphate or pyridoxine phosphate. The temperature of the phosphorylation reaction is controlled to be 30-38 DEG C, after the reaction is finished, protein separation is conducted on reaction liquid, mother liquor is separated, the compound pyridoxal phosphate or pyridoxine phosphate shown in the formula I is obtained, and the mother liquor is recycled and reused. According to the method, a large amount of ammonium acetophosphate does not need to be additionally added, operation is simpler, mother liquor can be recycled, a large amount of waste water is prevented from being discharged, environment friendliness is better achieved, and the yield is high.

The invention belongs to the technical field of nylon 66 polymer performance testing, and particularly relates to a method for simultaneously testing the content of iodide ions and bromide ions in a nylon 66 polymer, which comprises the following steps of: extracting the iodide ions and the bromide ions in the polymer by using weak acid salt (sub-carbonate or bicarbonate) instead of potassium nitrate as an ionic strength regulator; the acid environment in the extracted solution is adjusted with formic acid, silver nitrate is adopted as a titrant, iodide ions and bromide ions in the extract liquor are detected at the same time through potentiometric titration, and the problem that the iodide ions and the bromide ions cannot be detected at the same time is solved.

The invention relates to the technical field of metal surface protection materials, in particular to a composite antirust agent with mildew-proof and antirust performance and a preparation method thereof.The preparation method comprises the following steps that S1, 5-nitroisophthalic acid and metal oxide are subjected to a heating reaction, and a reaction mixture containing 5-nitroisophthalic acid salt is generated; s2, carrying out separation and purification; s3, drying treatment is carried out, and dry powder is obtained; s4, premixing with a mildew inhibitor, a corrosion inhibitor, an antioxidant and a silane coupling agent to obtain uniform composite powder; and S5, mixing the composite powder, a surfactant and an organic solvent to obtain a composite antirust agent finished product. According to the invention, a composite system composed of 5-nitroisophthalic acid zinc and a plurality of functional auxiliary agents is constructed, so that synchronous mildew-proof and rust-proof protection on the metal surface in a high-humidity environment and an environment where microorganisms are easy to breed is realized, and the coating stability and the long-term protection reliability are remarkably improved.

The invention relates to the technical field of medical crystallization, and particularly discloses benzocain-2, 6-dihydroxy benzoate monohydrate as well as a preparation method and application thereof. The benzocain-2, 6-dihydroxy benzoate monohydrate has the following characteristic diffraction peaks in an X-ray powder diffraction pattern which is determined by adopting rays: the diffraction angle values are 6.28 degrees, 12.48 degrees, 15.12 degrees, 17.40 degrees, 19.44 degrees, 22.92 degrees, 23.88 degrees, 26.46 degrees and 27.76 degrees. According to the invention, benzocaine is taken as an active ingredient, 2, 6-dihydroxybenzoic acid monohydrate is taken as a salt-forming agent, and the formed salt can obviously improve the water solubility, antibacterial property and stability of benzocaine; and the preparation method is simple to operate, low in energy consumption, low in solvent consumption, even free of solvent, good in product reproducibility and beneficial to industrial production.

The invention relates to the technical field of metal electroplating, in particular to a method for improving three-proofing performance of an electroplated cadmium layer, which comprises the following steps of: performing pretreatment processes of chemical oil removal, activation and neutralization on a sample to ensure that the sample is clean and has matched activity; then alkaline DMH cadmium plating is carried out, so that environmental pollution is avoided, and the corrosion resistance of a plating layer is enhanced; and finally, trivalent chromium passivation treatment and water-soluble silica gel sealing treatment are carried out, the damp-heat resistance, mold resistance and acid and salt mist corrosion resistance of the electroplated cadmium layer in the acid salt mist environment are improved, air stop treatment is carried out after trivalent chromium passivation treatment and water-soluble silica gel sealing treatment, full oxidation of a passivation film is effectively promoted, and the service life of the passivation film is prolonged. And the corrosion resistance of the passive film is enhanced.

The present invention provides a process for the production of an organic acid from an aqueous medium of a monovalent salt of an organic acid using bipolar electrodialysis via a three compartment electrodialysis unit.

The application discloses a preparation method of battery-grade nanometer titanium dioxide, which comprises the following steps: dissolving a strong alkali weak acid salt as a pH regulator into ice water to make titanium salt completely hydrolyzed to prepare titanic acid; and using sodium hydroxide as the pH regulator to make the titanic acid further converted into a crystalline precursor to prepare a titanium complex [Ti(OH)4(OH)2] 0 Then, the complex is sheared and dispersed, and then subjected to a hydrothermal reaction; after the reaction is completed, the product is completely washed with water and calcined to prepare nanometer titanium dioxide. The prepared nanometer titanium dioxide has super-low impurity content, small particle size and uniform particle size distribution; the total content of magnetic substances, including Cr, Fe, Ni and Zn, is less than 0.2 ppm; the particle size is 0-100 nm; and the average particle size is 50 nm, so that the nanometer titanium dioxide is an excellent material for battery doping.

The embodiment of the invention provides a cerium oxide-gold nano catalytic material and a preparation method thereof, and the preparation method comprises the following steps: adding weak acid and strong alkali weak acid salt into deionized water, and uniformly stirring to obtain a buffer solution; adding a cerium source and a gold source into the buffer solution, and uniformly stirring to form a mixed solution; after the mixed solution is subjected to a photo-reduction reaction, the mixed solution is moved into a hydrothermal reaction kettle to be subjected to a hydrothermal reaction, and a cerium oxide-gold mixture is obtained; after the cerium oxide-gold mixture is cooled to the room temperature, precipitates are obtained through centrifugation; washing the precipitate with deionized water for multiple times, and drying to obtain a cerium oxide-gold nano catalytic material; wherein the cerium oxide-gold nano catalytic material comprises cerium dioxide and nano-gold loaded on the surface of the cerium dioxide, the cerium dioxide and the nano-gold are spherical or sphere-like, and the particle size of the cerium dioxide and the particle size of the nano-gold are both 3-15 nm. The preparation method disclosed by the embodiment of the invention is simple, and the prepared cerium oxide-gold nano catalytic material is relatively high in catalytic performance.

The application relates to the technical field of H2O2 preparation, and discloses a method for preparing a supported catalyst by using an alkali metal additive, the supported catalyst and application of the supported catalyst, the method comprises the following steps: (1) contacting a solution containing an active component precursor, an inorganic alkaline substance and an alkali metal additive with a carrier to obtain a solid-liquid mixture; (2) drying and activating the solid-liquid mixture; wherein the active component precursor is a Pd precursor, and the alkali metal additive is a strong alkali metal acid salt and / or a weak alkali metal acid salt. By using the inorganic alkaline substance and the strong alkali metal acid salt in combination, the content of Pd in a reduced state in the prepared catalyst can be increased.

A resin composition according to one embodiment of the present disclosure comprises: a base resin containing a polyarylene sulfide resin; and at least one higher aliphatic acid compound selected from the group consisting of higher aliphatic acids, higher aliphatic acid esters, and higher aliphatic acid salts.

The application discloses a fluid inclusion standard sample for in-situ isotopic analysis and a preparation and application thereof. The preparation method comprises the following steps: obtaining silicate glass powder with uniform components, carrying out high-temperature and high-pressure reaction on the glass powder and an equal mass of a fluid salt solution in a closed Cu-Au tube, taking out a reaction product after the reaction and drying the reaction product, and obtaining the fluid inclusion standard sample for isotopic analysis. The application can rapidly capture fluid inclusions in the silicate glass with uniform components, and accurately measure and control Cu isotopes in the fluid inclusions by the degree of Cu isotope fractionation between the acid salt melt and the fluid.

The present invention belongs to the field of medicinal chemistry and relates to a triazine-thiazolidinone compound and its preparation method and application. Its structural formula is wherein R1 is any one of alkyl, pyranyl, indolyl, phenyl or thienyl. Its pharmaceutically acceptable salt is the acid salt of the compound, and the acid is any one of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, boric acid, methanesulfonic acid, p-toluenesulfonic acid, naphthalenesulfonic acid, benzenesulfonic acid, citric acid, lactic acid, pyruvic acid, tartaric acid, acetic acid, trifluoroacetic acid, maleic acid, succinic acid, mandelic acid, fumaric acid, salicylic acid or phenylacetic acid. The triazine-thiazolidinone compound skeleton provided by the present invention is novel, has a good inhibitory effect on glucose transporter 1 (GLUT1), and its inhibitory effect in HT29 cells is much better than that of positive control compound BAY-876, with good potential for further development as an anti-tumor drug.

The invention discloses high-specificity acamproate as well as a preparation method and application thereof. The preparation method comprises the following steps: providing activated zeolite; uniformly mixing homotaurine, the activated zeolite, water and an acylation reagent in a weakly alkaline environment, and carrying out acetylation reaction to obtain acamproic acid; and carrying out a salt forming reaction on a salt forming compound and the acamproic acid to prepare the acamproic acid salt. The preparation method provided by the invention is simple in process steps, high-purity acamproate can be obtained without complicated purification operation, the problems of low acetylation reaction selectivity, easiness in hydrolysis of an acylation reagent, insufficient product purity and the like in the traditional process are solved, and the preparation method is suitable for industrial production.

This invention discloses a method for removing water and carbon dioxide from a mixed gas, comprising: contacting the mixed gas with a weak acid salt molecular sieve adsorbent, wherein the weak acid salt molecular sieve adsorbent selectively adsorbs water and carbon dioxide molecules, while simultaneously excluding other gases with molecular dynamic diameters larger than that of the mixed gas, thereby achieving the removal of water and carbon dioxide from the mixed gas. The preparation method of the weak acid salt molecular sieve adsorbent includes the following steps: (1) selective adsorption of weak acid salt species: placing the molecular sieve in a weak acid salt solution and allowing the two to come into full contact at a certain temperature, so that the weak acid salt species are selectively adsorbed into the molecular sieve channels; (2) high-temperature calcination: drying the molecular sieve after the selective adsorption of weak acid salt species in step (1) and calcining it at 350-650°C in an inert atmosphere and / or air atmosphere to obtain the weak acid salt molecular sieve adsorbent.

The purpose of the present invention is to provide a technique whereby the decomposition of a surfactant can be greatly suppressed without adding a stabilizer. The problem is solved by a method for suppressing decomposition of a surfactant in a cleaning solution for aluminum or an aluminum alloy, the cleaning solution containing an inorganic acid, iron ions, and 0.1-10 g / L of the surfactant, the cleaning solution having a pH of 2 or less. The method includes a step of adding one or more oxoacid salts selected from the group consisting of monooxygenated acid salts and diooxygenated acid salts to the cleaning solution.