33 results about "Acid salt" patented technology

This invention discloses a method for preparing and analyzing trans-4-aminocyclohexylacetic acid. The preparation method is as follows: 4-nitrophenylacetic acid undergoes catalytic hydrogenation in a solvent, followed by filtration. The filtrate is then treated with acid to obtain a 4-aminophenylacetic acid salt solution. The collected catalyst is activated. The 4-aminophenylacetic acid salt solution is mixed with isopropanol, barium hydroxide, tetrabutylammonium bromide, 18-crown ether-6, and dibutyl phthalate. The activated catalyst is then added to initiate a catalytic hydrogenation reaction. After the reaction, the reaction solution is cooled and filtered. The resulting solid is mixed with a preheated dilute sulfuric acid solution and stirred to form a slurry. The mixture is then filtered, and the filtrate is neutralized and filtered again. The collected filtrate is concentrated and crystallized. The crystallized precipitate is washed and dried to obtain trans-4-aminocyclohexylacetic acid. The method provided by this invention has high reaction efficiency, mild conditions, and is suitable for industrial production. It yields high product purity and reliability. Furthermore, the analytical method provided by this invention is accurate and reliable.

The application relates to the technical field of H2O2 preparation, and discloses a method for preparing a supported catalyst by using an alkali metal additive, the supported catalyst and application of the supported catalyst, the method comprises the following steps: (1) contacting a solution containing an active component precursor, an inorganic alkaline substance and an alkali metal additive with a carrier to obtain a solid-liquid mixture; (2) drying and activating the solid-liquid mixture; wherein the active component precursor is a Pd precursor, and the alkali metal additive is a strong alkali metal acid salt and / or a weak alkali metal acid salt. By using the inorganic alkaline substance and the strong alkali metal acid salt in combination, the content of Pd in a reduced state in the prepared catalyst can be increased.

Provide are an acid salt of a class of nitrogen-containing heterocyclic derivatives and a crystal form thereof, a preparation method therefor, and a use thereof. Specifically, provided are an acid salt of a compound represented by general formula (I) and a crystal form thereof, a preparation method therefor, and a pharmaceutical composition containing a therapeutically effective amount of the crystal form, as well as a use thereof as an inhibitor in the treatment of cardiovascular diseases, cerebrovascular diseases, and other diseases.

The present application belongs to the technical field of medicine crystal form, and particularly relates to acid salts of lasmiditan, in particular, 2,3-dihydroxybenzoic acid salt of lasmiditan and 3,5-dihydroxybenzoic acid salt of lasmiditan. The new salt type of lasmiditan has high solubility, in particular, the solubility of 2,3-dihydroxybenzoic acid salt of lasmiditan in 37°C water, pH6.8 phosphate buffer is as high as 73.85, 79.22 mg / ml, which is beneficial to better therapeutic effect of the medicine; meanwhile, the stability is excellent, the crystal form does not change in the influencing factor test, and the purity change is relatively small, and the mechanical stability is good, which is convenient for preparation processing.

The present application relates to a polymorph of acid salt of pyrimidine aniline compound, preparation method and application. Specifically, the present application discloses a polymorph of acid salt of compound of formula (A) and a preparation method thereof, and application of the polymorph. According to the results of comprehensive thermodynamic stability relationship and solid state property evaluation, the present application provides that the citrate salt crystal form I of formula (A) is a preferred crystal form, the physicochemical properties are stable, and the crystal form can be better used in clinic.

This invention provides an ultrafiltration device for tanshinone polyphenolic acid salt extract, belonging to the field of ultrafiltration technology for tanshinone polyphenolic acid salt extract. The ultrafiltration device includes a main body and an anti-clogging mechanism. The anti-clogging mechanism includes a threaded rod rotatably mounted on the right side wall of the inner cavity of the ultrafiltration device main body. A screw block is threadedly connected to the outer surface of the threaded rod, and two discharge hoppers are provided on the outer surface of the screw block. A rotating rod is rotatably mounted on the right side wall of the inner cavity of the ultrafiltration device main body. A dual-shaft motor is externally mounted on the ultrafiltration device main body. Both output shafts of the dual-shaft motor are fixedly mounted with connecting shafts via couplings. The outer surfaces of both connecting shafts are provided with main conical teeth. The threaded rod has a first driven conical tooth on its outer surface, and the rotating rod has a second driven conical tooth on its outer surface. A fixing block is fixedly mounted on the outer surface of the rotating rod. Two support plates are provided on the outer surface of the fixing block, and a fixing rod is located between opposite sides of the two support plates. A disc is provided on the outer surface of the fixing rod. The advantages are: preventing ultrafiltration membrane clogging and improving the filtration efficiency of the ultrafiltration membrane.

Disclosed are wash resistant compositions for altering the tone or color of the hair, the compositions comprising a hair coloring agent comprising an oxidation base chosen from toluene-2,5-diamine, acid salts thereof, or solvates thereof, and a coupler system comprising at least one coupler chosen from 1-napthol, 2-amino-4-hydroxyethylaminoanisole sulfate, and derivatives thereof, addition salts thereof, solvates thereof, or solvates of salts thereof; or mixtures thereof, as well as methods of using the compositions.

This invention relates to a purification method for a key intermediate of citalopram, namely 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile or a salt thereof. The method includes treating a mixed solution of 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile and a water-insoluble organic solvent with a washing solution, then taking the organic layer for further separation to obtain the free base of 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile; or adding acid to form a salt, separating the acidic salt of 4-[4-(dimethylamino)-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile. The method provided by this invention can effectively remove aldehyde impurities from the intermediate.

This invention discloses a lignin-reinforced self-healing conductive elastomer, its preparation method, and its applications. The preparation method includes the following steps: mixing lipoic acid, lignin, a metal acid salt ionic liquid, and an organic crosslinking agent, followed by heat treatment to obtain the lignin-reinforced self-healing conductive elastomer; the mass ratio of lipoic acid to lignin is 1:(0.025~0.055). The lignin-reinforced self-healing conductive elastomer of this invention not only possesses good tensile strength but also exhibits excellent strain, temperature, and light-induced multimodal sensing properties. Furthermore, its electrical and tensile properties after damage also demonstrate excellent self-healing capabilities. In addition, both the polylipoic acid and lignin used in this invention are bio-based materials, avoiding the use of petroleum-based materials, making it environmentally friendly.

This application discloses nalmefene base, its preparation method, and its application, belonging to the field of pharmaceutical technology. The preparation method of nalmefene includes the following steps: mixing nalmefene hydrochloride with water to form an aqueous solution of nalmefene hydrochloride; reacting the aqueous solution of nalmefene hydrochloride with an aqueous solution of an alkaline component to form nalmefene base; the pH of the nalmefene hydrochloride is 4.0-6.5; the alkaline component includes at least one selected from sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, sodium acetate, ammonia, and sodium dihydrogen phosphate. This application uses nalmefene hydrochloride with a pH of 4.0-6.0 to undergo a desalting reaction with an aqueous solution of a strong base-weak acid salt or a weak base, crystallizing out nalmefene base. This effectively controls the particle size and shape of nalmefene base, obtaining small-particle-size, low-content, stable, and poorly soluble tablet-shaped nalmefene base without pulverization. It is less prone to burst release, meeting the requirements for sustained-release formulations, and the reaction is mild, green, and economical.

The present invention relates to a crystal form of a sulfoximine compound, a preparation method therefor, and a use thereof. Specifically, disclosed are a crystal form of a compound as shown in a formula (I), a preparation method therefor, and a use thereof. The crystal form has excellent stability, and can be widely applied to the preparation of drugs for preventing and / or treating diseases related to increased FGFR2 activity and expression level. The crystal form is preferably a hydrochloride crystal form I of the compound represented by formula I, and the X-ray powder diffraction pattern of the hydrochloride crystal form I has a 2θ angle selected from the following group: 6.68 + / -0.2 degrees, 13.34 + / -0.2 degrees, and 21.42 + / -0.2 degrees.

The utility model provides a kind of sewage depth defluorination system, it is related to sewage treatment field, including inlet pipe, outlet pipe, alkalinity adjusting mechanism, sewage treatment mechanism and control panel, the one end of inlet pipe is communicated with alkalinity adjusting mechanism, the alkalinity adjusting mechanism is communicated with sewage treatment mechanism, the sewage treatment mechanism is communicated with outlet pipe, water quantity monitor is equipped on inlet pipe, water quantity monitor is electrically connected with control panel;The utility model is through the control of total alkalinity and the alkalinity supplement of weak acid salt, maintains defluorination system pH stable, both can avoid high pH condition, the defluorination efficiency drop caused by the rapid hydrolysis settlement of defluorination agent (aluminum salt), also avoided the difficulty removal of large amounts of aluminum fluoride polymer formed when pH drops in the hydrolysis process of aluminum salt when adding defluorination agent under neutral condition, to reduce the residue of fluorine and aluminum in effluent.

A process for the preparation of Levoketoconazole (1) includes reacting ketoconazole with (1S)-(+) camphor sulphonic acid in a solvent to give (1S)-(+) camphor sulphonic acid salt of Levoketoconazole; treating Levoketoconazole Camphor sulphonic acid with an aqueous base to give crude Levoketoconazole (1); and isolating and purifying crude Levoketoconazole (1) to yield pure Levoketoconazole (1). A process for the preparation of crystalline anhydrous Levoketoconazole (1) is also included.

This invention provides a crystalline CSF-1R inhibitor acid salt, its preparation method, and its applications. The CSF-1R inhibitor is a compound having the structure of formula (I), namely 3,3-dimethyl-N-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)-2-oxopyrrolidine-1-carboxamide. The crystalline acid salt compound significantly improves the physicochemical properties of the free form of formula (I), such as solubility, hygroscopicity, and chemical stability, meeting the requirements of industrial production and satisfying the needs of clinical drug formulation development. The crystalline acid salt compound can be widely used in the preparation of drugs for treating cancer, tumors, autoimmune diseases, metabolic diseases, or metastatic diseases.

Described herein are 2-naphthalenesulfonic acid salt forms of Compound (I), compositions containing those salt forms, and processes for their preparation. Also described are uses of the 2-naphthalenesulfonic acid salt forms of Compound (I) and associated compositions for the treatment of diseases, disorders, and conditions.(I)

A lubricating oil additive composition including: (i) a Broensted acid salt of at least one first amide compound, the Broensted acid salt being a salt of the first amide compound and a Broensted acid, the first amide compound being a monoamide of at least one fatty acid (a1), and at least one amine compound (a2), the amine compound (a2) being an oligomer of at least one alkanolamine (a3) represented by the general formula (1):in the formula, n is 1 or 2; R1 is C1-4 linear chain alkylene or C3-10 branched chain alkylene, the C3-10 branched chain alkylene having a main chain, the main chain having a carbon number of 2; and when n is 2, a plurality of R1's may be the same, and may be different from each other.

CSF-1R inhibitor pharmaceutical compositions, methods for preparing the same, and their pharmaceutical uses. The CSF-1R inhibitor composition contains a free base of a compound of formula (I) having the following structure or an acid salt of a compound of formula (I) as an active ingredient. By using appropriate diluents and other pharmaceutically acceptable carriers to adjust the formulation components of the pharmaceutical product, the fluidity and color uniformity of the active pharmaceutical ingredient powder are improved, thereby obtaining formulations and pharmaceutical products. [Formula 1] TIFF2026518324000040.tif37142

The present application relates to cyanide-free gold plating technical field, disclose a kind of cyanide-free electroplating solution and application and the preparation method of rose gold plating layer.The cyanide-free electroplating solution includes: gold salt, copper salt, auxiliary complexing agent, brightener and color forming regulator;Wherein, auxiliary complexing agent includes ethylenediamine tetraacetic acid disodium, citrate and tartrate;Brightener is nitrogen-containing vinyl polymer;Color forming regulator is inorganic oxygen-containing acid salt containing sulfur;The content of auxiliary complexing agent is 30-90g / L;The content of brightener is 0.01-1ppm;The content of color forming regulator is 0.1-2ppm.The stability of the electroplating solution is good, and the service life is long, the composition of rose gold plating layer can be accurately and stably controlled, the current density range of bright plating layer is wide, and the application in decorative electroplating, electronic parts electroplating or chip packaging electroplating can be realized, especially can be well applied to the electroplating of decorative parts with complex geometry.

This invention discloses a wet-mixed mortar for plastering robots, prepared by mixing a dry mixture of wet-mixed mortar with water. The dry mixture consists of the following raw materials: 114-132 parts cement; 211-223 parts dry sand; 464-495 parts manufactured sand; 38-44 parts fly ash; 12-16 parts slag; 1-1.7 parts polyhydroxycarboxylic acid salt; 0.8-1 part branched alkylbenzene sulfonate; 0.7-0.8 parts polycarboxylic acid; 0.3-0.5 parts air-entraining agent; 0.5-0.7 parts dispersant; and 0.1-0.4 parts retarder. The wet-mixed mortar of this invention exhibits good stability and uniformity, significantly extending the open time during transportation and waiting periods. After application to the wall, it promptly triggers hydration and normal setting and hardening, balancing the open time requirements for long-distance transportation with the time constraints of plastering operations. This fully ensures the continuity, reliability, and efficiency of automated construction by the plastering robot.

The application is a kind of O3 type sodium ion battery positive electrode material of reducing method induced residual base conversion. The chemical formula of the positive electrode material is Na 1+x Ni 0.33 Fe 0.33 Mn 0.33 P x O 2+2x In the preparation, the selected reducing acid salt, including but not limited to hypophosphite or bisulfite, is used as a residual base eliminator and a reducing agent, and through grinding and calcination, the mechanism of acid-base neutralization reaction and redox reaction is used to realize the functions of residual base conversion coating and surface coordination environment adjustment. The first coulombic efficiency of the battery obtained by the application is as high as 94%, the voltage hysteresis is greatly reduced, the capacity retention rate after 300 cycles at 1C is increased from 38% to 84%, and a new generation of coating scheme with great potential for scaling is provided for layered positive electrode materials.

This invention relates to the field of microbial detection and antibacterial technology, and particularly to a method for preparing a copper-containing antibacterial solution, comprising the following steps: mixing a copper-containing component with an antibacterial enhancing component to obtain a copper-containing antibacterial solution; wherein the antibacterial enhancing component is selected from at least one of tea polyphenols, amino acid compounds, and hydroxycarboxylic acid salts. The method for preparing the copper-containing antibacterial solution provided by this invention achieves a significant enhancement of the antibacterial effect by constructing a stable compound system with the antibacterial enhancing component and the copper-containing component. Simultaneously, it reduces the amount of copper ions used, improving both the antibacterial effect and safety.

The application provides a method for improving the yield of 2,5-furan dicarboxylic acid, wherein a proper amount of Lewis acid salt is added in the reaction process of promoting the carboxylation reaction of 2-furan carboxylic acid and CO2 to generate 2,5-furan dicarboxylic acid by alkali metal carbonate; the Lewis acid salt and furan molecules are activated by adsorption coordination on H on the furan ring molecule, which is beneficial to promote the C-H deprotonation process of the furan ring molecule. The activation of the Lewis acid is utilized, and it is found that the Lewis acid and the alkali metal carbonate have a promoting effect in the carboxylation reaction of furfuryl acid and CO2, and have an improving effect on the yield of the reaction product 2,5-furan dicarboxylic acid.

This application relates to a natural collagen fiber, its preparation method, and its application. The preparation method of the natural collagen fiber includes: sequentially mixing and reacting dermal tissue particles derived from mammals with a first mixing reagent and a second mixing reagent to obtain impurity-free collagen particles; the first mixing reagent, by weight, includes water, a strong base-weak acid salt at 1%~3% by weight, and an inorganic base reagent at 0.15%~0.8% by weight; the second mixing reagent, by weight, includes water and a monohydric alcohol at 40%~50% by weight; and the impurity-free collagen particles are pulverized to obtain natural collagen fibers. This preparation method is simple, efficient, and has a high extraction rate. The obtained natural collagen fibers have a superhelical quaternary structure formed by the aggregation of natural triple helical structures, exhibiting alternating light and dark stripes; and the type I and type III collagen in the fibers are well preserved, with high protein purity.

The application discloses a preparation method of a GalNAc key intermediate and a new salt type and crystal form thereof. The application provides a preparation method of a high-purity compound 3, which comprises the following steps: freeing an acid salt of the compound 3 and / or a crystal form of the acid salt to obtain a pure product of the compound 3; and the acid is selected from one or more of L-dibenzoyl tartaric acid, D-dibenzoyl tartaric acid, L-di-p-methylbenzoyl tartaric acid, D-di-p-methylbenzoyl tartaric acid, L-di-p-methoxybenzoyl tartaric acid and D-di-p-methoxybenzoyl tartaric acid. The preparation method of the GalNAc key intermediate has the advantages of high purity, high yield and simple operation.