195 results about "Acid derivative" patented technology

The present disclosure relates to analytical LC-MS / MS methods for second tier testing in Newborn Screening Program (2ndtier test or 2TT) for the simultaneous measuring of organic acids, acylcarnitines, aminoacids derivatives and acylglicines in dried blood spot samples.

The application belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of chiral N-alkyl amino acid derivatives. The synthesis method is improved on the basis of the synthesis method of chiral N-alkyl amino acid derivatives in the prior art, has mild reaction conditions, high yield, is beneficial to industrial large-scale production, and solves the amplification effect of the synthesis method in the prior art.

The present invention relates to a novel synthesis of 2-fluoromethyl acrylate (MFA), which is a key precursor for the production of Veltassa® (Patiromer). The process according to the invention obtains MFA (III) by reacting an alpha-substituted beta-hydroxy propionic acid derivative (I) via one or more intermediate steps involving one or more alpha-, beta-substituted propionic acid derivatives (II).

The invention provides a method for synergistically removing impurities through pH regulation and complexing of ionic rare earth ore leachate, the ionic rare earth ore leachate is stirred and mixed uniformly, a plant polyphenol sulfonic acid derivative complexing agent is added, the complexing agent is prepared through sulfonation, neutralization, concentration and drying by taking gallic acid as a raw material, and the complexing agent can automatically regulate the pH value of the solution and stabilize the pH value at 5.1-5.3; under the condition, phenolic hydroxyl groups, carboxyl groups and sulfonic functional groups in complexing agent molecules preferentially form stable precipitates with impurity ions such as Al < 3 + > and Fe < 3 + > in the leachate, and the complexing effect with rare earth ions (RE < 3 + >) is weak; and after the reaction is completed, carrying out solid-liquid separation to obtain the purified leachate and impurity-containing precipitation slag. The method solves the problem of ammonia nitrogen pollution caused by use of ammonium bicarbonate, ammonia water and other ammonium salts in the traditional process, is a novel method with high impurity removal rate, simple process flow and environmental friendliness, and is suitable for industrial application.

The invention relates to the technical field of organic chemical synthesis, and discloses a method for preparing a chlorogenic acid derivative by condensing chlorogenic acid and a bifunctional amino acid derivative, which comprises the following step: in the presence of EDCI and HOBt, reacting chlorogenic acid with the bifunctional amino acid derivative in a DMF solvent to obtain the chlorogenic acid derivative. The method does not need to protect hydroxyl, the synthesis steps are simple, and the reaction is green, environment-friendly and pollution-free.

This invention discloses a 1,6-diamino-dibenzo[a,o]perylene-7,16-dione-2,5-disulfonic acid derivative, its preparation method, and its application. Using a vat dye derivative PR177 as the parent material, a 4,4'-diamino-1,1'-dianthraquinone-3,3'-disulfonic acid derivative is formed by the Ullmann condensation of a 1-amino-4-bromoanthraquinone-2-sulfonic acid derivative. This derivative is then cyclically closed via the McMurray reaction to form the 1,6-diamino-dibenzo[a,o]perylene-7,16-dione-2,5-disulfonic acid derivative. This allows for direct dyeing without the use of sodium hydrosulfite. Compared to soluble vat dyes, it is stable when exposed to air. Furthermore, due to its good planarity, it exhibits excellent dyeing performance as an acid dye. It combines the advantages of good directness of vat dyes and good water solubility of acid dyes, especially showing excellent color fastness and exhaustion rate in wool dyeing.

The present invention relates to pharmaceutical preparations containing as active ingredients 3-N-formylhydroxylaminopropylphosphonic acid derivatives or 3-N-acetylhydroxylaminopropylphosphonic acid derivatives in combination with clindamycin and artesunate for the treatment of malaria, in particular for the acute therapy of cerebral malaria, and to an associated dosage, in particular for the patient group of children.

The invention relates to a liquid crystal aligning agent, a liquid crystal alignment film, a manufacturing method of the liquid crystal alignment film, a liquid crystal element and a compound. A liquid crystal aligning agent which contains a polymer (A) that is at least one selected from the group consisting of polyamic acids, polyamic acid esters and polyimides and is obtained using two or more tetracarboxylic acid derivatives containing compounds represented by formula (1), and which satisfies at least one of requirements 1 and 2. Condition 1: In addition, a polymer (B) different from the polymer (A) is contained. Requirement 2: Two or more polymers (A) are contained. In formula (1), Y1 and Y2 independently represent a tetravalent organic group. And X1 represents a divalent organic group.

This application relates to the fields of chemistry and biomedicine, specifically to a tofenamic acid lipid composition, its preparation method, and its application. A tofenamic acid derivative is obtained by reacting a morpholine solution with tofenamic acid, ethyldimethylaminopropylcarbodiimide, and 4-dimethylaminopyridine, followed by purification. The morpholine in the morpholine solution is an N-alkylmorpholine compound. The tofenamic acid derivative is used to prepare tofenamic acid prodrug liposomes via ethanol injection, which are then used in combination with a STING agonist. The synergistic effect of the combined treatment stems from the dual regulation of the tumor immune microenvironment (TME), overcoming the immune escape induced by STING monotherapy. After STING agonist treatment, the intratumoral COX-2 / PGE2 axis is activated, leading to immunosuppression. The combination of tofenamic acid liposomes and a STING agonist inhibits COX-2, thus relieving this negative feedback loop.

The invention discloses a ferulic acid derivative and a preparation method and application thereof.The ferulic acid derivative is a compound shown in the formula (I) or pharmaceutically acceptable salt of the compound, and the compound is a natural compound extracted from rubus corchorifolius stems, has anti-inflammatory activity and anti-tumor activity and has the potential of being developed into anti-inflammatory or anti-tumor drugs. Or as a lead compound.

New derivatives of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo [3,4c] pyridine-3-carboxamide (Apixaban) able to increase its water solubility. These derivatives are cocrystals derivatives ofApixaban of different acids, from which the most outstanding are the following: Apixaban Malonic Acid derivative, Apixaban-a-Ketoglutaric Acid derivative, Apixaban-Gallic Acid derivative, Apixaban-Maleic Acid derivative, Apixaban-L-Tartaric Acid derivative, and Apixaban Citric Acid derivative.

The present disclosure relates to a method for synthesizing a substituted phenylpropionic acid derivative. Specifically, the present disclosure relates to a method for preparing a compound as represented by formula I or a pharmaceutically acceptable salt thereof, which method exhibits a good yield.

The purpose of the present invention is to provide a plant activator which is low in soil contamination and toxicity and excellent in plant growth promoting effect. A plant activator characterized by containing, as an active ingredient, a hydroxide fatty acid derivative having a structural formula (I) and / or (II), or a salt or ester thereof. (In the formula, R1 is a linear or branched hydrocarbon group having 4-12 carbon atoms, may include one or more double bonds and / or OH groups, and if a double bond is included, the position of the double bond is not limited; r2 is a linear or branched hydrocarbon group having 2 to 8 carbon atoms, may contain one or more double bonds and / or OH groups, and if a double bond is contained, the position of the double bond is not limited. HOOC-(R1)-CH (OH)-CH = CH-CH (OH)-R2 (I) HOOC-(R1)-CH (OH)-CH = CH-CH (OH)-R2 (II)

The present invention relates to a 6-Aryl imidazo[2,1-b]thi / oxazole-2-carboxilic acid derivative, and the compound according to the present invention is useful as a JNK3 inhibitor capable of acting specifically against JNK3. The inhibitory activity of the compound according to the present invention against JNK3 is relatively higher than that against JNK1 and JNK2, and thus it can be used as an Alzheimer's disease therapeutic agent with a low risk of side effects.

The invention discloses a preparation method of a 3-aryl pyrazolidine compound, which comprises the following steps: in an inert gas atmosphere, sequentially adding aryl cyclopropane, an azodicarboxylic acid derivative, NaBr and a photocatalyst into acetonitrile to obtain a mixture, reacting for 12 hours at room temperature under the irradiation of 5W blue light with the wavelength of 456nm, and separating from the reaction liquid to obtain the 3-aryl pyrazolidine-1, 2, 3-triazole compound. The invention relates to a 1, 2-dicarboxylic acid derivative. The preparation of the 3-aryl pyrazolidine compound can be carried out at room temperature, the reaction condition is mild, the adopted raw materials are simple and easy to obtain, and the cost is low.

The invention belongs to the technical field of medicines, and particularly relates to application of an echinacea caffeic acid derivative to preparation of a medicine or a feed additive for treating animal periodontal diseases and a composition containing the echinacea caffeic acid derivative. The invention discloses application of an echinacea caffeic acid derivative in preparation of a medicine for treating animal periodontal diseases. Experiments prove that the echinacea caffeic acid derivative has the effects of improving feline gingivitis, gingival bleeding, gingival atrophy, alveolar bone loss and the like, can be used for treating and preventing animal periodontal diseases, and has smaller toxic and side effects while ensuring that a better periodontal disease treatment effect can be realized.

The invention relates to the technical field of cosmetics, in particular to a composition for improving the sticky and greasy skin feeling of high-concentration glass color and a preparation method thereof.The composition is prepared from, by weight, 2-4 parts of glyceryl polyether surfactant, 0.1-1 part of amino acid derivative surfactant, 0.5-6 parts of hydrophilic siloxane derivative and 0.1-3.5 parts of microemulsion phase; the microemulsion phase is prepared from polyoxyethylene hydrogenated castor oil, sorbitan sesquiisostearate, isostearyl alcohol, isostearic acid, non-polar hydrocarbon grease, aliphatic dihydric alcohol and water. According to the composition, through the synergistic effect of the glyceryl polyether surfactant, the amino acid derivative surfactant, the hydrophilic siloxane derivative and the microemulsion phase, the sticky and greasy skin feeling of high-concentration glass color due to the formula is remarkably improved, the smearing freshness and consumer acceptance are improved, the formula process is simple, and industrial production is easy.

The invention belongs to the technical field of biomedicine synthesis, and particularly relates to the technical field of chemical synthesis of natural drugs / prodrugs for controlling metabolic abnormalities such as blood sugar and blood fat. The invention provides a preparation method of a cholic acid derivative. The preparation method comprises the following steps: adding benzyl bromide into an alkaline solution containing cholic acid to obtain benzyl cholate; the method comprises the following steps: adding a dichloromethane solution containing acyl chloride into a dichloromethane solution containing benzyl cholate and 4-dimethylaminopyridine under protective gas to obtain a colorless oily product; and introducing hydrogen into the absolute ethyl alcohol in which the colorless oily product is dissolved to obtain the cholic acid derivative. The chemical synthesis of the cholic acid derivative is realized.

This invention relates to the synthesis of compounds that can be used to treat bacterial infections in combination with other antibacterial agents, and more specifically in combination with a class of antibacterial agents known as carbapenems. The compounds resulting from the novel methods of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.

The application provides a MOFs-based antistatic agent, a polyurea coating and a preparation method thereof, and relates to the technical field of polyurea coatings.The MOFs-based antistatic agent comprises, according to mass, 0.2-1 parts of single-walled carbon nanotubes, 1.5-4 parts of an antistatic agent and 0.05-0.3 parts of a MOFs material.The metal salt involved in the MOFs material is an acetylacetone metal salt, and the ligand is 2-methylimidazole.The antistatic agent is at least one of a polyether type antistatic agent, a polyacrylate type antistatic agent, a sulfonic acid derivative type antistatic agent and a polyquaternary ammonium salt type antistatic agent.The MOFs-based antistatic agent provided by the application is applied to the polyurea coating, improves the antistatic property of the polyurea coating, reduces the viscosity of the polyurea coating, and the coating strength of the polyurea coating is relatively high.

This invention discloses a semi-synthetic metalworking fluid with rust-preventive properties and its preparation method. The fluid comprises, by mass fraction of raw materials: 25-30 parts base oil, 3-5 parts composite corrosion inhibitor, 0.1-0.3 parts non-ferrous metal corrosion inhibitor, 12-15 parts pH stabilizer, 8-11 parts main emulsifier, 3-5 parts auxiliary emulsifier, 0.8-1.5 parts calcium soap dispersant, 0.8-1.0 parts coupling agent, 2.5-3.5 parts bactericide, and 27.7-44.8 parts water. This invention utilizes a composite corrosion inhibitor of dodecyl diacid (DDDA) and triazine polycarboxylic acid derivatives, compounded in a specific ratio, to construct a dual protective mechanism of "microscopic hydrophobic adsorption" and "macroscopic chemical passivation" on the metal surface. This synergistic effect greatly enhances the density and adhesion of the protective film.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

This invention discloses a phenylnaphthic acid derivative and its application in phosphorescent information encryption. The preparation method involves using 3,5-bis(ethoxycarbonyl)phenylboronic acid and methyl 6-bromo-2-naphthylcarboxylate as raw materials, and then performing a Suzuki coupling reaction under tetra(triphenylphosphine)palladium(O) catalysis to obtain the intermediate ethyl 2-(3,5-bis(ethoxycarbonyl)phenyl)-6-naphthylcarboxylate. This intermediate is then subjected to alkaline hydrolysis and acidification to obtain the target product, 2-(3,5-dicarboxyphenyl)-6-naphthylcarboxylic acid. This phosphorescent material has a simple preparation method, lower cost compared to noble metal phosphorescence systems, a simple guest synthesis method with high yield, and exhibits significant and stable phosphorescence effects. Furthermore, precise emission color control of high-performance doped thin films is achieved through the triplet-to-singlet Förster fluorescence resonance energy transfer (TS-FRET) mechanism, establishing a multicolor long-lifetime emission system. In addition, the material has multi-color adjustable properties and excellent long afterglow emission performance, showing great application potential in cutting-edge application fields such as multi-dimensional information encryption and high-end anti-counterfeiting.

The present application relates to the technical field of asiatic acid, and particularly relates to an asiatic acid derivative and a preparation method.The asiatic acid derivative provided by the present application has R which is a straight chain or a branched chain with 1-24 carbon atoms, or a saturated or unsaturated monohydric alcohol alkyl formed by removing a hydroxyl group.The R group of the asiatic acid derivative of the present application has higher water solubility and oil solubility, especially oil solubility, so that the asiatic acid derivative has obviously enhanced liposolubility compared with asiatic acid, is easily dissolved in natural oil, alkane and other ester solvents, and has obviously enhanced biological activity, so that the asiatic acid derivative of the present application has high availability, improves the inhibition effect of the asiatic acid derivative on EDNRA and TRPV1, and further improves the anti-tumor effect, and the asiatic acid derivative has no safety risk.

The invention relates to extended-release formulations comprising substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof that can activate adenosine 5'-monophosphate- activated protein kinase (AMPK). The invention further relates to methods of treating a condition comprising administering an extended-release formulation comprising AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof.

This invention relates to the field of fine chemical catalysis technology, specifically to an improved ion-gel confined palladium-on-carbon catalyst, its preparation method, and its applications. The catalyst uses N,N-dimethylacetamide (DMAc) as a solvent and potassium acetate as a base, with the addition of a catalytic amount of antioxidant 168 [(tris(2,4-di-tert-butylphenyl) phosphite)], and the reaction is carried out under milder CO pressure (1.0-1.6 MPa) and temperature (90-110 °C). This improved catalyst, in synergy with the optimized process, unexpectedly enables the high conversion and selectivity of 4-bromobenzyl sulfone derivatives to 4-methylsulfonylbenzoic acid derivatives, while maintaining the catalyst's excellent recyclability and stability. This invention provides a highly efficient, green, and easily industrialized synthetic route for the target product.

This invention discloses a sialyl polysaccharide-sialic acid-binding immunoglobulin-like lectin signaling pathway blocker, containing one or more N-acetylneuraminic acid derivatives, used to manufacture immunotherapy synergistic drugs or immunomodulatory drugs. The immunotherapy synergistic drugs are used in combination with immunotherapy drugs, and the immunomodulatory drugs are used to enhance the regulation of immunity.

The invention relates to the technical field of tobacco antibacterial substances, in particular to a fatty acid derivative and a preparation method thereof, an antibacterial compound and a pesticide. The fatty acid derivative is selected from compounds represented by the following structural formula: wherein R is selected from phenyl or CX, and X represents halogen. The fatty acid derivative has a good inhibition effect on phytophthora nicotianae, and can be used as a pesticide for preventing and treating tobacco black shank, so that the selection of antibacterial drugs and pesticides is expanded.