348results about "Peroxide active ingredients" patented technology

The invention relates to hydrogel loaded with oxygen self-producing nanoparticles as well as a preparation method and application of the hydrogel. The preparation method comprises the following steps: 1, taking cross-linked methacrylamide silk fibroin and hyaluronic acid modified by arginine-glycine-aspartic acid peptide as base materials, and loading self-oxygen-producing nano particles CaO2 (at) PVP (at) Cu-EGCG, and the self-oxygen-producing nano particles CaO2 (at) PVP (at) Cu-EGCG are prepared by coating Cu-EGCG on calcium peroxide nano particles modified by PVP modified polyvinylpyrrolidone. The hydrogel can improve energy metabolism and regulate immune environment through dual mechanisms, realizes efficient promotion of myocardial repair, and provides a new strategy and thought for tissue regeneration and functional recovery after myocardial infarction.

The invention relates to a strontium peroxide nano-material, which is characterized in that a strontium source, alkali and hydrogen peroxide are used as raw materials, a mixed solution of an organic solvent and water is used as a reaction solvent, the strontium peroxide nano-material is prepared under a template or template-free condition, and the strontium peroxide nano-material can quickly react with water to generate hydroxyl, hydrogen peroxide and oxygen, hydrogen peroxide can achieve a tumor cell killing effect, hydroxyl can neutralize an acidic tumor microenvironment and alkalify tumor cells, and oxygen can relieve a hypoxic tumor microenvironment. In addition, the strontium peroxide nano material can induce macrophages to be polarized to an anti-tumor M1 type by regulating and controlling glycometabolism of the macrophages, and remodeling an intra-tumor lactic acid metabolism crosstalk mode. The strontium peroxide nano-material or the modified material and the preparation thereof can be directly injected into a tumor or near the tumor under ultrasonic guidance to realize in-situ treatment, or can be delivered to a tumor supply blood vessel through a catheter to realize embolism treatment, so that the strontium peroxide nano-material or the modified material and the preparation thereof have a certain application prospect in the field of tumor treatment.

The present invention relates to an oxygen-carrying nanoliposome in which oxygen is carried inside a shell of a phospholipid bilayer, and use thereof. The nanoliposome continuously releases oxygen, thereby maintaining an oxygen delivery effect for a long time, and increases anticancer efficacy without damaging the cells by delivering oxygen specifically to tumor cells.

The invention provides a photodynamic and chemotherapy synergistic antibacterial composite material, the composite material comprises an intermediate composite material and hyaluronic acid HA coating the outer side of the intermediate composite material, and the intermediate composite material takes a photosensitizer i-ZnPPOPs as a substrate and is loaded with calcium peroxide and gentamicin. The composite material has excellent bacteria targeting characteristic and antibacterial effect. Specifically, hyaluronic acid can target hyaluronidase secreted by bacteria so as to capture the bacteria, and then the intermediate composite material is transferred to the surfaces of the bacteria and interacts with negatively charged bacterial membranes. Then, the exposed biomass-based CaO2 is released and reacts with water to generate H2O2 and O2, so that oxygen deficit of the infected wound surface is relieved, generation of < 1 > O2 in the i-ZnPPOPs is effectively promoted, and the photodynamic antibacterial effect is further improved. Meanwhile, the released gentamicin can further improve the antibacterial efficiency of the chemotherapy.

The invention discloses a preparation method and application of pH-responsive double-synergistic-therapy hydrogel. The hydrogel is mainly prepared from oxidized fucoidin (OFU), carboxymethyl chitosan (CMCs), zinc peroxide / copper nanoparticles (ZnO < 2-Cu >) and arginine (L-ARG). Under a gastric acid condition, the hydrogel generates H2O2 through zinc peroxide, copper ions catalyze H2O2 through a Fenton-like reaction to generate OH <->, arginine can catalyze H2O2 to generate NO, and the copper ions and the arginine act together to destroy a helicobacter pylori biological membrane and kill bacteria. The hydrogel has good injectability, self-healing property and adhesivity, is beneficial to intragastric injection application and can be adhered to the stomach, and the administration concentration of an infected part is improved; the antibacterial effect is generated only under the gastric acid condition, the helicobacter pylori biological membrane can be destroyed, and the helicobacter pylori antibacterial agent can be applied to the helicobacter pylori which is difficult to eradicate in the stomach of the human body.

The invention discloses an establishment method and a verification method of a hydrogen peroxide induced mouse autism model, and relates to the technical field of medical biologication.The establishment method of the hydrogen peroxide induced mouse autism model comprises the following steps that a hydrogen peroxide solution is injected into the abdominal cavity of a pregnant mouse, hydrogen peroxide induction is conducted, and the mouse autism model is obtained. And obtaining a hydrogen peroxide induced offspring mouse, namely the mouse autism model. Hydrogen peroxide is used for near intraperitoneal injection of a female mouse during pregnancy, the oxidative stress state of the female mouse during pregnancy and the oxidative stress state of an offspring mouse embryo are induced through independent hydrogen peroxide, and obvious immune response of the female mouse is not caused, so that an ASD mouse model specifically induced by oxidative stress is formed; the obtained ASD offspring mouse has a remarkable ASD phenotype, but does not show obvious dyskinetic disorder.

The invention provides an active oxygen free radical generation method and application thereof. According to the method, a PFC nanoemulsion is utilized to catalyze H2O2 to generate active oxygen free radicals (hydroxyl radical.OH). The principle of generating reactive oxygen free radicals by the method is as follows: a PFC nanoemulsion and an H2O2 aqueous solution are adopted to form a liquid-liquid interface, interface contact is promoted through vortex or ultrasound, water molecules and hydroxyl ions are induced to lose electrons and generate. OH by utilizing a contact electrification effect, and PFC captures the electrons to form PFC * with negative electricity; then, H2O2 obtains electrons from PFC *, and OH is generated again. The method can be used in the fields of environmental pollutant degradation and drug preparation. The function and mechanism of the PFC nanoemulsion for catalyzing H2O2 to generate. OH active oxygen free radicals are found for the first time, the new application of the PFC nanoemulsion is widened, an important scientific basis is provided for developing a novel catalysis strategy, and the PFC nanoemulsion has important theoretical and application values.

The invention discloses a polydopamine modified and cupric peroxide loaded ZIF8 nano particle and application thereof, and belongs to the technical field of medicine preparation. According to the invention, a zeolite imidazoline framework 8 is used as a matrix, CuO2NPs is uniformly modified in the zeolite imidazoline framework 8 to form CuO2 (at) ZIF8NPs, and the surface of the CuO2 (at) ZIF8NPs is coated with a polydopamine film in the form of a film. The invention constructs multifunctional ZIF8NPs (CuO2 (at) ZIF8 (at) PDANPs) which is coated with PDA and loaded with CuO2NPs, and the multifunctional ZIF8NPs (CuO2 (at) ZIF8 (at) PDANPs is used for CDT of thermal enhancement OS. The CuO2 (at) ZIF8 (at) PDA NPs is combined with a photothermal effect and a chemodynamic therapy, shows good biocompatibility and an anti-tumor curative effect, has a potential application prospect in the aspect of osteosarcoma, and provides a new thought and method for treatment of osteosarcoma.

The invention discloses an application of an Mxene-Mo4VC4 new member nano platform with light-enhanced peroxidase activity in treatment of methicillin-resistant staphylococcus aureus infection so as to promote healing of infected wounds, and belongs to the field of two-dimensional nano material catalyst antibacterial research. The single-layer Mo4VC4 nanosheet is synthesized on the basis of Mo4AlVC4-MXene through a hydrofluoric acid etching method. The Mo4VC4 nanosheet shows activity similar to peroxidase, and can locally catalyze low-concentration hydrogen peroxide and generate hydroxyl radicals toxic to bacteria, so that methicillin-resistant staphylococcus aureus is effectively killed, and a biological membrane is removed. In addition, high photo-thermal conversion efficiency and photo-thermal stability are shown under irradiation of near-infrared light with low concentration (50 mu g / mL). The similar peroxidase activity is obviously amplified by the temperature rise caused by the photothermal effect of the Mo4VC4 nanosheet. And finally, rapidly eliminating methicillin-resistant staphylococcus aureus in deep infection and accelerating abscess regression by adopting a satisfactory photo-thermal amplification peroxidase strategy.

A system for treating and / or preventing a viral, bacterial and / or fungal infection in the oral cavity and / or along the respiratory tract, in particular the interior of the nose, throat, trachea and / or lungs, of a patient by reactive species generated by plasma as well as a plasma for such use is disclosed. The system comprises a plasma source generating reactive species in a gas, the plasma source being configured to be located outside a body of the patient, and a species directing member forming at least one duct for guiding at least a part of the reactive species generated by the plasma source into the oral cavity and / or the respiratory tract.

The invention discloses peroxide hydrogel and a preparation method thereof. The peroxide hydrogel comprises peroxide and connecting molecules or salts thereof. The peroxide hydrogel is prepared by centrifugally cleaning a suspension formed by mixing a metal compound, a connecting molecule, hydrogen peroxide and an auxiliary agent in a solvent. According to the invention, an initiator and a cross-linking agent are not used, the peroxide is gelatinized by connecting molecules, the distribution is uniform, the viscoelasticity is excellent, the thixotropy is realized, the gel can be re-gelatinized after being applied in a sol state, and the slow release property is realized.

Methylthioninium salt-containing compositions can include methylthioninium chloride (Methylene Blue) in combination with additional compounds that work cooperatively and / or synergistically to treat various conditions. In one example, the methylthioninium salt-containing composition can include methylthioninium chloride, caffeine, and L-theanine. The methylthioninium chloride and the caffeine can be present at a weight ratio from about 1:75 to about 1:4. the methylthioninium chloride and the L-theanine can be present at a weight ratio from about 1 :200 to about 1:10, and the caffeine and the L- theanine can be present at a weight ratio from about 1 :5 to about 1:1.

The invention provides core-shell structure nanoparticles with a mediated microenvironment for rheumatoid arthritis treatment and a preparation method thereof.The preparation method comprises the steps that a calcium peroxide precursor is dissolved in absolute ethyl alcohol containing a surfactant, and calcium peroxide nanoparticles are obtained by adding an ammonia water solution and a hydrogen peroxide solution; the preparation method comprises the following steps: carrying out surface treatment on calcium peroxide nanoparticles by using tannic acid to form a tannic acid molecular layer on the surfaces of the calcium peroxide nanoparticles so as to obtain tannic acid modified calcium peroxide nanoparticles; and forming a metal phenolic network shell on the surface of the tannic acid modified calcium peroxide nano-particle by using cerium acetate to obtain the core-shell structure nano-particle.

The invention discloses an S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction as well as a preparation method and application thereof, and belongs to the field of antibacterial application of nano materials. The three-dimensional porous carbon nitride not only can increase photocatalytic active sites, but also can improve close contact with copper sulfide. The copper sulfide nanospheres and the three-dimensional porous nanosheets construct an S-shaped heterojunction, and efficient separation of photo-induced electrons and hole pairs can be driven under the action of a built-in electric field, band edge bending and coulomb force. The S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction can generate more active oxygen species to inactivate bacteria through a photocatalysis-Fenton-like reaction; in addition, the photothermal effect of copper sulphide has a certain auxiliary sterilization effect. Under the conditions of visible light irradiation and trace hydrogen peroxide, the inactivation rates of the S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction on staphylococcus aureus and escherichia coli are up to 99.5% and 99.7% respectively, and meanwhile, the S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction has a remarkable treatment effect on wounds infected by staphylococcus aureus.

The invention discloses a core-shell microneedle for removing bacterial biofilms and a preparation method of the core-shell microneedle, and belongs to the technical field of biological medicines. The core-shell microneedle comprises a shell layer and a core layer, the shell layer comprises a shell layer material and copper peroxide nanoparticles loaded on the shell layer material, and the core layer comprises a core layer material and mesoporous polydopamine nanoparticles loaded on the core layer material, coated with citraconate and capable of targeting neutrophils. The biofilm can penetrate through a biofilm and preferentially release copper peroxide nanoparticles, the oxidation-reduction steady state in the biofilm is destroyed, bacteria are killed, and the biofilm is dispersed; the polypeptide can target neutrophil, relieve the immunosuppression state of congenital immune cells and recover the bacterial killing ability of the congenital immune cells, so that escaped bacteria are effectively phagocytized; through the synergistic effect of the two, the biological membrane can be completely removed, the biological membrane removing agent has a clinical application prospect, and bacterial drug resistance caused by long-term use of antibiotics is reduced.

Percarbonate and percarbonate compositions, for example a dietary supplement or a pharmaceutical composition, are disclosed along with their uses, such as improving physical performance of a subject, increasing recovery from physical exertion of a subject, reducing lactic acid burn of a subject, and / or preventing, treating, or curing a percarbonate-improvable condition of a subject that causes fatigue and / or malaise.

The present invention relates to means and methods comprising a bacterial heme peroxidase and / or a functional fragment thereof for medical and non-medical use in preventing and / or controlling a pathogen on food, plants, or in or on the human or animal body. The present invention thus relates to novel medical and non-medical uses of a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants, or on the human or animal body. Furthermore, the present invention relates to corresponding methods comprising a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants or on or in the human or animal body comprising applying a sufficient amount of the bacterial heme peroxidase and / or a functional fragment thereof on said food, plants, or on mucosae, skin, in particular epidermal skin like scalp or facial skin and / or teeth to reduce the number of cells of said pathogen. In addition, the invention relates to specific heme peroxidases that have been identified to have desired properties. The invention also relates to fragments of or small heme peroxidases that have particularly advantageous properties. Moreover, the present invention further relates to corresponding compositions comprising a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants, or in or on the human or animal body. Kits comprising components used in the methods and compositions of the invention are also provided herein. Furthermore, provided is the use of a bacterial heme peroxidase and / or of a functional fragment thereof for the preparation of the compositions of the present invention. The present invention finally also relates to a method for producing a bacterial heme peroxidase protein and / or a functional fragment thereof in an engineered Bacillus subtilis strain. The inventive use of the bacterial heme peroxidase of the present invention and / or a functional fragment thereof for preventing and / or controlling a pathogen is, without being limiting, particularly useful in ecologically compatible commercial plant / crop protection campaigns as well as in daily personal care products such as toothpaste for example.

The invention discloses a targeted enhanced copper death-immunomodulator and a preparation method and application thereof, and belongs to the technical field of medical materials.The targeted enhanced copper death-immunomodulator comprises a polydopamine nanoparticle (PDA) substrate and a CuO2 nano-dot compounded CuO2 PDA nano-composite, the CuO2 PDA nano-composite is wrapped with a cell membrane, and the cell membrane is coated with a polydopamine nano-particle (PDA) substrate and a polydopamine nano-particle (PDA) nano-dot. According to the invention, a targeting ligand of a programmed cell death ligand-1 (Program Cell Death Ligand 1, PD-L1) is grafted on a cell membrane, and the targeting ligand of the Program Cell Death Ligand 1 (PD-L1) is grafted on the cell membrane. The regulator can be efficiently accumulated to a tumor site in a targeted manner, on one hand, the regulator can produce H2O2 in situ in a tumor, the intracellular oxidation-reduction balance is broken, the yield of active oxygen in the tumor is enhanced, and then tumor cell copper death is enhanced; on the other hand, the regulator can durably reduce the abundance of PD-L1 on the surfaces of tumor cells, and finally the purpose of multi-path combined efficient tumor immunotherapy is achieved.

The invention discloses a lipid nano drug delivery system and application of a preparation method of the lipid nano drug delivery system in improvement of tumor vessel normalization, the lipid nano drug delivery system comprises a drug, CaO2 nanoparticles and an anionic liposome, and the drug and the CaO2 nanoparticles are jointly loaded on the anionic liposome; the surfaces of the CaO2 nanoparticles are provided with positive charges, and the preparation raw materials of the anion liposome contain 1, 2-dioleoyl-sn-glycerol-3-sodium phosphate. The lipid nano drug delivery system can enhance the generation of endothelial cell-derived NO through Met and other drugs and Ca < 2 + > mediated eNOS activation, so that NO concentration gradient is formed around tumor blood vessels to realize tumor blood vessel normalization, the tumor immunosuppression microenvironment is reversed, and the tumor calcium overload treatment effect is improved.

The invention provides a multifunctional cisplatin liposome as well as a preparation method and application thereof. The liposome is prepared from epigallocatechin gallate, cis-platinum, zinc peroxide nanoparticles, a distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000 long-acting fragment, a distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000-oestrone targeting fragment, lecithin and cholesterol, and the particle size of the liposome is 80 to 130 nm. According to the multifunctional liposome disclosed by the invention, the zinc peroxide nanoparticles are introduced, so that the function of slowly releasing oxygen in a tumor microenvironment can be realized, and oxygen deficit is reversed; through targeting fragment modification, an active targeting effect can be realized by combining with an estrogen receptor highly expressed on the surface of a breast cancer cell; the epigallocatechin gallate and cis-platinum are co-loaded, so that the sensitivity of chemotherapeutic drugs can be improved, the toxic and side effects of the chemotherapeutic drugs are reduced, a good breast cancer resisting effect is achieved, and the tumor volume is remarkably reduced.

The invention discloses a preparation method of engineered bacteria for releasing CO gas under initiation of ultrasonic waves to kill tumor cells, and relates to a preparation method of CO carrier engineered bacteria. The invention aims to solve the problems that the existing CO carrier material is low in delivery efficiency, the CO is difficult to release efficiently and controllably in space and time at the same time, and the existing metal CO carrier material is high in toxicity. Meanwhile, the problems that the penetrating power of light waves to biological tissues is limited, and the CO release efficiency is limited due to a tumor hypoxic microenvironment are solved. The preparation method comprises the following steps: 1, modifying the surface of escherichia coli with 3-hydroxyflavone-D-alanine; and 2, continuously modifying the surface of the escherichia coli with CaO2 (at) polymyxin B. The method is used for preparing the engineered bacteria for releasing the CO gas through ultrasonic initiation to kill the tumor cells.

The invention relates to a peroxy sorbate polymer for active oxygen response as well as a preparation method and application of the peroxy sorbate polymer. The structural general formula of the peroxy sorbate polymer is shown as a formula I: # imgabs0 #, R1 is selected from chain alkyl, naphthenic base, benzyl, benzyl derivative group, aryl or aryl derivative group, and n is equal to 6-300. Compared with the prior art, the peroxysorbate polymer provided by the invention has active oxygen release ability, can enhance the active oxygen level in tumor cells, further regulates oxidative damage of the tumor cells and inhibits growth of the tumor cells, and can supplement the deficiency of active oxygen enhanced polymer molecule synthesis and application fields.

The present application relates to a kind of plant source exosome-encapsulated drug-loaded calcium-based nanogenerator and preparation method and its application, the nanogenerator includes drug-loaded core, the drug-loaded core outside is coated with plant source exosome shell layer;Wherein, the plant source exosome shell layer is selected from one or more of curcuma source exosome, broccoli source exosome, artemisia annua source exosome, camellia source exosome.This nanogenerator of the present application has the ability of enhancing calcium overload and amplifying cell oxidative stress, the generator can improve the stability and biocompatibility of CaO2 While, overcome tumor cell antioxidant defense mechanism.By curcuma source exosome as protective layer wrapped outside CaO2, solve the problem of CaO2 In vivo blood circulation stability and dispersibility, increase the efficiency of the nanogenerator into tumor cell.

The present invention relates to compositions and kits comprising hyaluronic acid or a pharmaceutically acceptable salt thereof, and one or more inorganic peroxide (CaO2 ZnO2 and / or MgO2) for use in the prevention or treatment of wounds, and / or pathological conditions requiring wound healing, tissue regeneration and / or bone regeneration. The present invention is in particular suitable for the prevention or treatment of a gum disease.

The present disclosure relates to micellar compositions conformed by biomimetic phospholipids and nonionic surfactants, among other ingredients, for eliminating one or more types of microorganisms including mycobacteria, bacteria, fungi, and viruses from a surface within a contact time on the surface of less than about 1 minutes and having pH of from about 0.3 to 8. The present invention aims on using 100% bio-based (renewable) biodegradable, non-toxic ingredients to be applied not only to hard inanimate surfaces but also on tissue for endodontic applications.

The present invention relates to a new multifunctional debridement and / or antifouling composition comprising H2O2 at a final concentration of between 0.1-5% v / v, and a composite hydrogel formulation comprising pluronic acid at a concentration of 10-40% w / v, wherein the composition is in liquid form at room temperature. The composition disclosed herein is antimicrobial and / or anti-inflammatory and is particular useful in periimplantitis treatment and implant health maintenance, in periodontitis and periodontal health and in wound care and chronic ulcer care.

Compositions and methods for treating solid cancer are provided. Specifically, the disclosure provides compositions comprising haloperoxidases, and methods comprising administering such compositions, for treating solid cancer.

The application belongs to the technical field of biological medicine, and particularly relates to a kind of composite nanoparticles and its preparation method and application.The composite nanoparticles provided by the application include nano calcium peroxide, hyaluronic acid coated on the surface of the nano calcium peroxide and urease coated on the surface of the hyaluronic acid.In the application, the hyaluronic acid has tumor cell targeting property, which is conducive to accurately delivering the composite nanoparticles to tumor cells;at the same time, the hyaluronic acid can fix the urease on the surface of the nano calcium peroxide, which is conducive to improving the biological mineralization rate.In the application, when the composite nanoparticles enter the tumor microenvironment under the condition of providing urea outside, they are affected by the acidic microenvironment, the nano calcium peroxide decomposes to release calcium ions, and at the same time, the urease specifically decomposes urea in the microenvironment to release carbonate ions, the calcium ions and carbonate ions produce a mineral layer on the surface of the cell membrane through synergistic effect, thereby blocking the channel of cell material exchange and inducing cell apoptosis.

According to the hydrogel material disclosed by the invention, the gelatin / gallic acid conjugate with a specific concentration is taken as a base material, and the base material is cross-linked by utilizing a horse radish peroxidase / hydrogen peroxide combined enzyme catalysis system, so that an additional photo-thermal response material does not need to be added in the gelling process of the hydrogel; in the cross-linking process, the hydrogel serves as a cross-linked structure for forming the interior of the hydrogel and shows excellent photo-thermal responsiveness, and the hydrogel can respond to photo-thermal temperature rise to improve the self deformability, so that irregular wounds are better covered; therefore, the invention provides a hydrogel material which has good biological safety, oxidation resistance and bacteriostasis and can be used for wound injury repair.

A syringe that suppresses decomposition of hydrogen peroxide is provided. An object of the present invention is to provide a pre-filled syringe having at least a barrel thereof made of a material having high decomposition capability with respect to hydrogen peroxide, including: a hydrogen peroxide solution therein; and an oil composition applied to an inner wall of the barrel, the oil composition containing silicone oil.