117results about "Peroxide active ingredients" patented technology

A system for treating and / or preventing a viral, bacterial and / or fungal infection in the oral cavity and / or along the respiratory tract, in particular the interior of the nose, throat, trachea and / or lungs, of a patient by reactive species generated by plasma as well as a plasma for such use is disclosed. The system comprises a plasma source generating reactive species in a gas, the plasma source being configured to be located outside a body of the patient, and a species directing member forming at least one duct for guiding at least a part of the reactive species generated by the plasma source into the oral cavity and / or the respiratory tract.

The present invention relates to means and methods comprising a bacterial heme peroxidase and / or a functional fragment thereof for medical and non-medical use in preventing and / or controlling a pathogen on food, plants, or in or on the human or animal body. The present invention thus relates to novel medical and non-medical uses of a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants, or on the human or animal body. Furthermore, the present invention relates to corresponding methods comprising a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants or on or in the human or animal body comprising applying a sufficient amount of the bacterial heme peroxidase and / or a functional fragment thereof on said food, plants, or on mucosae, skin, in particular epidermal skin like scalp or facial skin and / or teeth to reduce the number of cells of said pathogen. In addition, the invention relates to specific heme peroxidases that have been identified to have desired properties. The invention also relates to fragments of or small heme peroxidases that have particularly advantageous properties. Moreover, the present invention further relates to corresponding compositions comprising a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants, or in or on the human or animal body. Kits comprising components used in the methods and compositions of the invention are also provided herein. Furthermore, provided is the use of a bacterial heme peroxidase and / or of a functional fragment thereof for the preparation of the compositions of the present invention. The present invention finally also relates to a method for producing a bacterial heme peroxidase protein and / or a functional fragment thereof in an engineered Bacillus subtilis strain. The inventive use of the bacterial heme peroxidase of the present invention and / or a functional fragment thereof for preventing and / or controlling a pathogen is, without being limiting, particularly useful in ecologically compatible commercial plant / crop protection campaigns as well as in daily personal care products such as toothpaste for example.

The invention discloses a preparation method of engineered bacteria for releasing CO gas under initiation of ultrasonic waves to kill tumor cells, and relates to a preparation method of CO carrier engineered bacteria. The invention aims to solve the problems that the existing CO carrier material is low in delivery efficiency, the CO is difficult to release efficiently and controllably in space and time at the same time, and the existing metal CO carrier material is high in toxicity. Meanwhile, the problems that the penetrating power of light waves to biological tissues is limited, and the CO release efficiency is limited due to a tumor hypoxic microenvironment are solved. The preparation method comprises the following steps: 1, modifying the surface of escherichia coli with 3-hydroxyflavone-D-alanine; and 2, continuously modifying the surface of the escherichia coli with CaO2 (at) polymyxin B. The method is used for preparing the engineered bacteria for releasing the CO gas through ultrasonic initiation to kill the tumor cells.

The present disclosure relates to micellar compositions conformed by biomimetic phospholipids and nonionic surfactants, among other ingredients, for eliminating one or more types of microorganisms including mycobacteria, bacteria, fungi, and viruses from a surface within a contact time on the surface of less than about 1 minutes and having pH of from about 0.3 to 8. The present invention aims on using 100% bio-based (renewable) biodegradable, non-toxic ingredients to be applied not only to hard inanimate surfaces but also on tissue for endodontic applications.

The application belongs to the technical field of biological medicine, and particularly relates to a kind of composite nanoparticles and its preparation method and application.The composite nanoparticles provided by the application include nano calcium peroxide, hyaluronic acid coated on the surface of the nano calcium peroxide and urease coated on the surface of the hyaluronic acid.In the application, the hyaluronic acid has tumor cell targeting property, which is conducive to accurately delivering the composite nanoparticles to tumor cells;at the same time, the hyaluronic acid can fix the urease on the surface of the nano calcium peroxide, which is conducive to improving the biological mineralization rate.In the application, when the composite nanoparticles enter the tumor microenvironment under the condition of providing urea outside, they are affected by the acidic microenvironment, the nano calcium peroxide decomposes to release calcium ions, and at the same time, the urease specifically decomposes urea in the microenvironment to release carbonate ions, the calcium ions and carbonate ions produce a mineral layer on the surface of the cell membrane through synergistic effect, thereby blocking the channel of cell material exchange and inducing cell apoptosis.

This invention discloses a method for establishing and validating a hydrogen peroxide-induced mouse autism model, relating to the field of medical biotechnology. The method for establishing the hydrogen peroxide-induced mouse autism model includes the following steps: injecting the hydrogen peroxide solution into the peritoneal cavity of pregnant mice to induce hydrogen peroxide, resulting in offspring mice with hydrogen peroxide induction, i.e., the mouse autism model. This invention uses near-peritoneal injection of hydrogen peroxide during the gestational period of the mother mouse, inducing oxidative stress in both the pregnant mother mouse and the offspring embryo through hydrogen peroxide alone, without causing a significant immune response in the mother mouse. Therefore, an oxidative stress-specifically induced ASD mouse model is formed. The resulting ASD offspring mice exhibit significant ASD phenotypes but do not show obvious motor impairment.

The present disclosure provides a method for producing an electrolyte solution which can contain a high concentration of micro bubbles, and a method for producing a micro bubble-containing solvent which can be used for preparing the electrolyte solution, by suppressing decrease in micro bubbles during filtration.

Disclosed herein are methods for making compositions stably comprising one or more peroxides and one or more free available chlorine species, one or more peroxides for use in making compositions stably comprising one or more peroxides and one or more free available chlorine species, and compositions formulated using compositions made according to the methods or uses disclosed herein.

No method for treatment of distant tumor has been reported. A purpose of the present invention is to provide a pharmaceutical composition that is used in combination with radiotherapy to activate immunity against tumor, and that comprises a hydrogen peroxide solution. Another purpose of the present invention is to provide a method for activating immunity against tumor, the method comprising: a step for providing the pharmaceutical composition; a step for administering the pharmaceutical composition to a target site of a patient having the tumor; and a step for irradiating the target site with radiation. The tumor is distant from the target site of the patient having the tumor.

The present invention relates to oral composition and the method of preparation and use of such composition for inhibiting, reducing, and / or disrupting oral biofilm. The composition comprises a stabilizing matrix, a cationic biocide, and a peroxide source.

The invention provides an anti-tumor targeting nano material and a preparation method thereof, and belongs to the field of novel targeting nano drugs. The method comprises the following steps: stirring and mixing up-conversion nanoparticles, calcium peroxide nanoparticles, manganese chloride and a chemotherapeutic drug in a water phase to obtain a drug-loading core; cystamine and 3-aminophenylboronic acid are dissolved in water, EDC and NHS are added, a first amidation reaction is carried out, and a cross-linking agent is obtained; dispersing the drug-loading core in a polyacrylic acid solution, adding a cross-linking agent, and then carrying out a cross-linking reaction to obtain an intermediate product; activating carboxyl on the surface of the intermediate product, and then carrying out second amidation reaction with cRGD-PEG-NH2, so as to obtain the anti-tumor targeting nano material. According to the application, a multifunctional nano platform integrating targeted enrichment, double-response precise drug release, chemotherapy-chemical kinetics-immune collaborative treatment and up-conversion imaging tracing is constructed, and specific efficient killing of tumors and inhibition of metastasis and relapse of the tumors are realized.

The present invention relates to a new multifunctional debridement and / or antifouling composition comprising H2O2 at a final concentration of between 0.1 - 5%v / v, and a composite hydrogel formulation comprising pluronic acid at a concentration of 10-40%w / v, wherein the composition is in liquid form at room temperature. The composition disclosed herein is antimicrobial and / or anti-inflammatory and is particular useful in periimplantitis treatment and implant health maintenance, in periodontitis and periodontal health and in wound care and chronic ulcer care.

The application provides a metal polyphenol network-wrapped calcium peroxide nanoparticle and a preparation method and application thereof, and belongs to the technical field of tumor treatment. The metal polyphenol network-wrapped calcium peroxide nanoparticle has a protective effect on unstable calcium peroxide nanoparticles; the released metal ions catalyze hydrogen peroxide to generate hydroxyl radicals under acidic conditions, and then kill tumor cells, realize chemical kinetic therapy, can also consume glutathione, enhance the accumulation of active oxygen, and then enhance the anti-tumor effect; when dispersed into an acidic environment, the metal polyphenol network layer thereof can rapidly degrade, expose the calcium peroxide nanoparticles, and then explosively release a large amount of calcium ions and oxygen, which can more effectively activate calcium overload and relieve the tumor hypoxic microenvironment; by loading drugs, the effective accumulation of the drugs in the tumor site is improved, the combined treatment of chemical kinetic therapy and chemotherapy is realized, and thus the anti-tumor immune response is activated, and the anti-tumor effect is improved.

The application provides a magnetic response composite hydrogel for integrated repair of bone defects and a preparation method thereof, and belongs to the technical field of medical materials. The composite hydrogel can efficiently inhibit tumor cell activity under the time sequence regulation of an external alternating magnetic field, and then provide a suitable microenvironment and key components for bone tissue regeneration, so that signal conversion and function connection from tumor killing to bone repair are realized. The material has good injectability and self-healing ability, can minimally invasively fill irregular defects, and has significant advantages in simplifying the clinical treatment procedure, shortening the treatment course, reducing the risk of tumor recurrence and improving the repair quality, and provides a new and integrated treatment strategy for tumor-related bone defects.

The invention relates to the field of auxiliary materials for close-range radiotherapy of gynecological tumors and plasma medicine, in particular to plasma activated mucous membrane coating hydrogel, a preparation method and application. The plasma activated mucous membrane coating hydrogel consists of a hydrogel matrix which can be compatible with mucous membranes and active oxygen nitrogen which is introduced by plasma activation and can be controlled to release under the condition of 37 DEG C, the hydrogel meets the requirement that the apparent release half-life period of active oxygen nitrogen is 0.5-12 hours. The plasma activated mucous membrane coating hydrogel disclosed by the invention integrates lubrication and protection and active oxygen nitrogen mediated repair promotion / anti-inflammatory / antibacterial functions; active oxygen nitrogen short-time controlled release can be matched with fractional treatment; dose perturbation lt; 3%, image positioning is not interfered; the preloaded sheath is discarded when being used, or is smeared as ointment after treatment, and is simple to use.

The invention provides a high-concentration hydrogen peroxide emulsion for treating senile plaques and application thereof, and in the high-concentration hydrogen peroxide emulsion, hydrogen peroxide is used as an active component, can oxidize and decompose melanin in skin, and has a freckle removing effect; the hydrogenated polydecene is used as an emollient, so that the skin can be moistened and the texture of the skin is improved; hydrogenated castor oil (PEG-40) is used as an emulsifier, so that an emulsion system is stable; the bisabolol has anti-inflammatory and soothing effects, and can relieve the irritation of hydrogen peroxide to the skin; citric acid can adjust the pH value of the emulsion, so that the emulsion is more suitable for the physiological environment of skin; sodium hyaluronate has a moisturizing effect and can enhance the barrier function of skin. All the components have a synergistic effect, so that the emulsion has a good senile plaque treatment effect, and meanwhile, irritation to skin is reduced.

The application discloses a kind of lipid nano-drug delivery system and its preparation method in the application of improving tumor vascular normalization, the lipid nano-drug delivery system includes drug, CaO2 Nanoparticle and anionic liposome, the drug and CaO2 Nanoparticle are co-loaded in the anionic liposome;The surface of the CaO2 Nanoparticle is with positive charge, and the preparation raw material of the anionic liposome contains 1,2-dioleoyl-sn-glycerol-3-phosphoric acid sodium salt. 2+ The lipid nano-drug delivery system can enhance endothelial cell-derived NO production by mediating eNOS activation of Met and other drugs and Ca

The invention discloses a multifunctional nano-enzyme with self-driven cascade catalytic activity and a preparation method and application thereof, and relates to the field of diabetes wound repair materials, and the nano-enzyme comprises the following components: copper peroxide nano-dots, a zinc-based metal organic framework and glucose oxidase. According to the invention, a step-by-step synthesis strategy is adopted, copper peroxide nano-dots are uniformly encapsulated in a zinc-based metal organic framework, and then glucose oxidase is immobilized through surface modification, so that the nano-enzyme is constructed. The nano enzyme can realize self-driven triple enzyme cascade reaction through ingenious structural design, and plays a synergistic treatment role in a diabetes infected wound microenvironment. The nano-enzyme can effectively reduce blood sugar, efficiently sterilize, relieve inflammation and promote revascularization, and an innovative and efficient treatment scheme is provided for treatment of diabetes infected wounds.

The application provides a preparation method of oxygen-releasing gelatin for wound healing and application thereof, and relates to the technical field of gelatin preparation.The preparation method comprises the following steps: mixing gelatin with water, adding a mixture of neutral protease and chymotrypsin, carrying out enzymolysis at pH 5.5-6.5 and a temperature of 45-55 DEG C for 10-15 min, inactivating, and obtaining pretreated gelatin by using a dialysis bag with a molecular weight cut-off of 10-15 kDa; mixing the pretreated gelatin with water, adding 30wt%-32wt% hydrogen peroxide solution, stirring, adding 32wt%-34wt% hydrogen peroxide solution, and stirring; continuously adding 30wt%-32wt% hydrogen peroxide solution and stirring; obtaining a crude product; and purifying.The application combines specific enzymolysis pretreatment, an oxidation process and purification to prepare gelatin with better oxygen-releasing capacity, bacteriostatic capacity and significant promotion of skin wound healing, and the gelatin is safe and effective.

The invention belongs to the technical field of biological medicine, and particularly relates to a bionic photoactive nano preparation for tumor treatment as well as a preparation method and application thereof, and the preparation method comprises the following steps: synthesizing CaO2 (at) PDA-IR780 from nano calcium peroxide, polydopamine and iodide IR780, and synthesizing CaO2 (at) PDA-IR780 (at) M through a cell membrane coating technology. The obtained CaO2 (at) PDA-IR780 (at) M is a bionic photoactive nano preparation, the PDT effect of IR780 can be enhanced through in-situ oxygen production of nano calcium peroxide to improve the curative effect on tumors, controllable release of the preparation in the tumors is achieved through PDA acid response, and in-vivo long circulation and tumor targeted delivery are achieved through functional modification of nano particles through cell membranes. The photodynamic and photothermal activity is high, the tumor targeting characteristic and safety are good, and the application prospect in tumor treatment is wide.

The application discloses a rehmannia polysaccharide, a preparation method thereof and application of the rehmannia polysaccharide in preparation of a medicine for preventing and treating kidney injury caused by cisplatin. The rehmannia polysaccharide contains the following monosaccharides in percentage by mass: rhamnose (Rha) 10.265%-14.963%, glucuronic acid (GlcA) 0.514%-0.904%, galacturonic acid (GalA) 35.784%-40.596%, glucose (Glc) 3.128%-5.048%, galactose (Gal) 37.892%-41.438% and arabinose (Ara) 3.869%-4.865%. The structure of the rehmannia polysaccharide is clear, and the rehmannia polysaccharide shows a significant improvement effect on cisplatin nephrotoxicity through cell experiments and animal experiments, and has important value for developing a new and effective prevention and treatment product of cisplatin-induced acute kidney injury.

The invention belongs to the technical field of catalyst materials, and particularly relates to a multi-enzyme active spiny carbon sphere material as well as a preparation method and application thereof. The multi-enzyme active spiny carbon sphere material comprises spiny carbon microspheres and Ir monoatoms loaded on the surfaces of the spiny carbon microspheres, the loaded Ir monoatoms comprise Ir-Ir diatom para sites, and the material combines the functions of metabolic inhibition and active oxygen generation, so that stubborn dental caries related biological membranes can be effectively removed.

Pharmaceutical formulations for topical dental administration or medical (e.g., implant) treatments are disclosed, comprising an effective amount of at least one antimicrobial compound; at least one peroxide source compound; and at least one gel agent. Methods for treating oral anatomical structures are also disclosed. The pharmaceutical formulations and methods of treatment provide oral anatomical benefits to patients, including, for example, reduction or halting of gum recession; reduction or halting of bone recession; reduction or halting of bone loss; reduction or elimination of pain; reduction or elimination of bleeding; reduction or elimination of swelling; enhanced bone regeneration; enhanced soft tissue repair; or combinations thereof.

A dispensing device is described which comprises a first chamber in which there is a first composition and a second chamber in which there is a second composition. The first and second compositions are formulated such that hydrogen peroxide production is possible only when the first composition is mixed with the second composition.

The present invention relates to a mixture or composition having therapeutic activity, preferably for topical administration, comprising: at least one metal salt, wherein the metal is selected from the group consisting of molybdenum (Mo), tungsten (W), vanadium (V), gold (Au), lanthanides, in particular lanthanum; at least one chelating agent; at least one source of peroxy radicals; at least one buffer. And to a pharmaceutical composition constituted by the mixture or comprising the mixture, to a process for the preparation thereof and to the uses thereof, in particular in the method for the treatment of viral infections, in particular viral infections involving viruses of the Herpesviridae family, or in anti-inflammatory treatments.

The present invention relates to usage of hydrogen peroxide compounds as active substance in elimination of diabetic retinopathy diseases and the symptoms resulting from these diseases, and pharmaceutical compositions comprising hydrogen peroxide as active substance in the treatment of said diseases.

The invention discloses an oxygen supply type g-C3N4-based photosensitizer and a preparation method thereof, and the method comprises the following steps: firstly calcining cyanuric acid to prepare carbon nitride, then mixing with a ferric nitrate ethanol solution, drying, and calcining in a mixed atmosphere of O2 and N2 to obtain Fe2O3 / g-C3N4; adding absolute methanol, adding calcium chloride and a sodium hyaluronate solution, and then sequentially adding H2O2 and ammonia water to react to obtain the photosensitizer. According to the CaO2 / FeCN photosensitizer with the core-shell-like structure prepared by the method, the overall size is optimized by sodium hyaluronate, and penetration of a blood brain barrier is facilitated. CaO2 is introduced to realize oxygen self-supply, so that the O2 concentration of the system is improved, and the limitation of oxygen deficit on PDT is relieved. The EPR test shows that the ROS yield is excellent, and the PDT belongs to type I PDT. Cell and animal experiments show that the photosensitizer has a good tumor cell killing effect under illumination, almost all tumors are killed in tumor mice through PDT tests, the biocompatibility and the safety are good, and the existing technical problems are effectively solved.

The invention belongs to the field of medical disinfectants, and discloses a medical wound surface disinfectant and a preparation method thereof. According to the disinfectant, hydrogen peroxide and silver ions are combined to construct a dual synergistic sterilization system, decomposition of hydrogen peroxide is inhibited through polyvinylpyrrolidone and a sodium citrate stabilizer, and a polyvinyl alcohol-acrylic acid copolymer or a carbomer slow-release carrier is introduced to realize long-acting sterilization for 12 hours; meanwhile, hydroxypropyl methyl cellulose, glycerol or urea is adopted to adjust the viscosity so as to ensure wound coverage and permeation, and a repairing agent is matched to promote epithelium regeneration. The disinfectant can quickly and efficiently sterilize pathogenic bacteria, has no irritation to skin and oral mucosa, is mild and reliable in effect, and can accelerate wound healing.

This invention belongs to the field of biomedical technology, specifically relating to an anti-tumor nanomaterial, its preparation method, and its application. The anti-tumor nanomaterial is formed by in-situ growth of calcium peroxide on the surface of black phosphorus nanosheets to create hierarchical black phosphorus-calcium peroxide nanosheets, followed by coating the surface of these composite nanosheets with hyaluronic acid. After entering tumor cells, the anti-tumor nanomaterial releases calcium ions and hydrogen peroxide, triggering an abnormal increase in calcium ions and oxidative stress within the cells, thereby causing mitochondrial dysfunction and inducing tumor cell death. Simultaneously, the released calcium ions combine with phosphate ions produced by the degradation of black phosphorus, forming calcium phosphate mineralization deposits within the tumor tissue, inducing tumor biocalcification. Changes in calcium signaling and the oxidative stress process can also promote the infiltration and activation of immune cells, thereby regulating the tumor immune microenvironment and achieving a synergistic effect of cell killing, biocalcification induction, and immune regulation within tumor tissue.