190results about "Peroxide active ingredients" patented technology

The invention relates to hydrogel loaded with oxygen self-producing nanoparticles as well as a preparation method and application of the hydrogel. The preparation method comprises the following steps: 1, taking cross-linked methacrylamide silk fibroin and hyaluronic acid modified by arginine-glycine-aspartic acid peptide as base materials, and loading self-oxygen-producing nano particles CaO2 (at) PVP (at) Cu-EGCG, and the self-oxygen-producing nano particles CaO2 (at) PVP (at) Cu-EGCG are prepared by coating Cu-EGCG on calcium peroxide nano particles modified by PVP modified polyvinylpyrrolidone. The hydrogel can improve energy metabolism and regulate immune environment through dual mechanisms, realizes efficient promotion of myocardial repair, and provides a new strategy and thought for tissue regeneration and functional recovery after myocardial infarction.

A system for treating and / or preventing a viral, bacterial and / or fungal infection in the oral cavity and / or along the respiratory tract, in particular the interior of the nose, throat, trachea and / or lungs, of a patient by reactive species generated by plasma as well as a plasma for such use is disclosed. The system comprises a plasma source generating reactive species in a gas, the plasma source being configured to be located outside a body of the patient, and a species directing member forming at least one duct for guiding at least a part of the reactive species generated by the plasma source into the oral cavity and / or the respiratory tract.

Methylthioninium salt-containing compositions can include methylthioninium chloride (Methylene Blue) in combination with additional compounds that work cooperatively and / or synergistically to treat various conditions. In one example, the methylthioninium salt-containing composition can include methylthioninium chloride, caffeine, and L-theanine. The methylthioninium chloride and the caffeine can be present at a weight ratio from about 1:75 to about 1:4. the methylthioninium chloride and the L-theanine can be present at a weight ratio from about 1 :200 to about 1:10, and the caffeine and the L- theanine can be present at a weight ratio from about 1 :5 to about 1:1.

The invention discloses an S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction as well as a preparation method and application thereof, and belongs to the field of antibacterial application of nano materials. The three-dimensional porous carbon nitride not only can increase photocatalytic active sites, but also can improve close contact with copper sulfide. The copper sulfide nanospheres and the three-dimensional porous nanosheets construct an S-shaped heterojunction, and efficient separation of photo-induced electrons and hole pairs can be driven under the action of a built-in electric field, band edge bending and coulomb force. The S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction can generate more active oxygen species to inactivate bacteria through a photocatalysis-Fenton-like reaction; in addition, the photothermal effect of copper sulphide has a certain auxiliary sterilization effect. Under the conditions of visible light irradiation and trace hydrogen peroxide, the inactivation rates of the S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction on staphylococcus aureus and escherichia coli are up to 99.5% and 99.7% respectively, and meanwhile, the S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction has a remarkable treatment effect on wounds infected by staphylococcus aureus.

The present invention relates to means and methods comprising a bacterial heme peroxidase and / or a functional fragment thereof for medical and non-medical use in preventing and / or controlling a pathogen on food, plants, or in or on the human or animal body. The present invention thus relates to novel medical and non-medical uses of a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants, or on the human or animal body. Furthermore, the present invention relates to corresponding methods comprising a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants or on or in the human or animal body comprising applying a sufficient amount of the bacterial heme peroxidase and / or a functional fragment thereof on said food, plants, or on mucosae, skin, in particular epidermal skin like scalp or facial skin and / or teeth to reduce the number of cells of said pathogen. In addition, the invention relates to specific heme peroxidases that have been identified to have desired properties. The invention also relates to fragments of or small heme peroxidases that have particularly advantageous properties. Moreover, the present invention further relates to corresponding compositions comprising a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants, or in or on the human or animal body. Kits comprising components used in the methods and compositions of the invention are also provided herein. Furthermore, provided is the use of a bacterial heme peroxidase and / or of a functional fragment thereof for the preparation of the compositions of the present invention. The present invention finally also relates to a method for producing a bacterial heme peroxidase protein and / or a functional fragment thereof in an engineered Bacillus subtilis strain. The inventive use of the bacterial heme peroxidase of the present invention and / or a functional fragment thereof for preventing and / or controlling a pathogen is, without being limiting, particularly useful in ecologically compatible commercial plant / crop protection campaigns as well as in daily personal care products such as toothpaste for example.

The invention discloses a preparation method of engineered bacteria for releasing CO gas under initiation of ultrasonic waves to kill tumor cells, and relates to a preparation method of CO carrier engineered bacteria. The invention aims to solve the problems that the existing CO carrier material is low in delivery efficiency, the CO is difficult to release efficiently and controllably in space and time at the same time, and the existing metal CO carrier material is high in toxicity. Meanwhile, the problems that the penetrating power of light waves to biological tissues is limited, and the CO release efficiency is limited due to a tumor hypoxic microenvironment are solved. The preparation method comprises the following steps: 1, modifying the surface of escherichia coli with 3-hydroxyflavone-D-alanine; and 2, continuously modifying the surface of the escherichia coli with CaO2 (at) polymyxin B. The method is used for preparing the engineered bacteria for releasing the CO gas through ultrasonic initiation to kill the tumor cells.

The invention relates to a peroxy sorbate polymer for active oxygen response as well as a preparation method and application of the peroxy sorbate polymer. The structural general formula of the peroxy sorbate polymer is shown as a formula I: # imgabs0 #, R1 is selected from chain alkyl, naphthenic base, benzyl, benzyl derivative group, aryl or aryl derivative group, and n is equal to 6-300. Compared with the prior art, the peroxysorbate polymer provided by the invention has active oxygen release ability, can enhance the active oxygen level in tumor cells, further regulates oxidative damage of the tumor cells and inhibits growth of the tumor cells, and can supplement the deficiency of active oxygen enhanced polymer molecule synthesis and application fields.

The present application relates to a kind of plant source exosome-encapsulated drug-loaded calcium-based nanogenerator and preparation method and its application, the nanogenerator includes drug-loaded core, the drug-loaded core outside is coated with plant source exosome shell layer;Wherein, the plant source exosome shell layer is selected from one or more of curcuma source exosome, broccoli source exosome, artemisia annua source exosome, camellia source exosome.This nanogenerator of the present application has the ability of enhancing calcium overload and amplifying cell oxidative stress, the generator can improve the stability and biocompatibility of CaO2 While, overcome tumor cell antioxidant defense mechanism.By curcuma source exosome as protective layer wrapped outside CaO2, solve the problem of CaO2 In vivo blood circulation stability and dispersibility, increase the efficiency of the nanogenerator into tumor cell.

The present disclosure relates to micellar compositions conformed by biomimetic phospholipids and nonionic surfactants, among other ingredients, for eliminating one or more types of microorganisms including mycobacteria, bacteria, fungi, and viruses from a surface within a contact time on the surface of less than about 1 minutes and having pH of from about 0.3 to 8. The present invention aims on using 100% bio-based (renewable) biodegradable, non-toxic ingredients to be applied not only to hard inanimate surfaces but also on tissue for endodontic applications.

The application belongs to the technical field of biological medicine, and particularly relates to a kind of composite nanoparticles and its preparation method and application.The composite nanoparticles provided by the application include nano calcium peroxide, hyaluronic acid coated on the surface of the nano calcium peroxide and urease coated on the surface of the hyaluronic acid.In the application, the hyaluronic acid has tumor cell targeting property, which is conducive to accurately delivering the composite nanoparticles to tumor cells;at the same time, the hyaluronic acid can fix the urease on the surface of the nano calcium peroxide, which is conducive to improving the biological mineralization rate.In the application, when the composite nanoparticles enter the tumor microenvironment under the condition of providing urea outside, they are affected by the acidic microenvironment, the nano calcium peroxide decomposes to release calcium ions, and at the same time, the urease specifically decomposes urea in the microenvironment to release carbonate ions, the calcium ions and carbonate ions produce a mineral layer on the surface of the cell membrane through synergistic effect, thereby blocking the channel of cell material exchange and inducing cell apoptosis.

According to the hydrogel material disclosed by the invention, the gelatin / gallic acid conjugate with a specific concentration is taken as a base material, and the base material is cross-linked by utilizing a horse radish peroxidase / hydrogen peroxide combined enzyme catalysis system, so that an additional photo-thermal response material does not need to be added in the gelling process of the hydrogel; in the cross-linking process, the hydrogel serves as a cross-linked structure for forming the interior of the hydrogel and shows excellent photo-thermal responsiveness, and the hydrogel can respond to photo-thermal temperature rise to improve the self deformability, so that irregular wounds are better covered; therefore, the invention provides a hydrogel material which has good biological safety, oxidation resistance and bacteriostasis and can be used for wound injury repair.

This invention discloses a method for establishing and validating a hydrogen peroxide-induced mouse autism model, relating to the field of medical biotechnology. The method for establishing the hydrogen peroxide-induced mouse autism model includes the following steps: injecting the hydrogen peroxide solution into the peritoneal cavity of pregnant mice to induce hydrogen peroxide, resulting in offspring mice with hydrogen peroxide induction, i.e., the mouse autism model. This invention uses near-peritoneal injection of hydrogen peroxide during the gestational period of the mother mouse, inducing oxidative stress in both the pregnant mother mouse and the offspring embryo through hydrogen peroxide alone, without causing a significant immune response in the mother mouse. Therefore, an oxidative stress-specifically induced ASD mouse model is formed. The resulting ASD offspring mice exhibit significant ASD phenotypes but do not show obvious motor impairment.

The present invention relates to usage of hydrogen peroxide compounds as active substance in elimination of diabetic retinopathy diseases and the symptoms resulting from these diseases, and pharmaceutical compositions comprising hydrogen peroxide as active substance in the treatment of said diseases.

The present disclosure provides a method for producing an electrolyte solution which can contain a high concentration of micro bubbles, and a method for producing a micro bubble-containing solvent which can be used for preparing the electrolyte solution, by suppressing decrease in micro bubbles during filtration.

The present specification discloses a method of making a composition stably comprising one or more peroxides and one or more free available chlorine species, one or more peroxide for use in the manufacture of a composition stably comprising one or more peroxides and one or more free available chlorine species, as well as formulated compositions using a composition manufactured according to a method or use disclosed herein.

The present invention relates to a composition comprising a liquid or a hydrogel comprising reactive oxygen and nitrogen species (RONS) and a STAT3 inhibitor, as well as to the use of said composition in the treatment of cancer.

Disclosed herein are methods for making compositions stably comprising one or more peroxides and one or more free available chlorine species, one or more peroxides for use in making compositions stably comprising one or more peroxides and one or more free available chlorine species, and compositions formulated using compositions made according to the methods or uses disclosed herein.

The invention discloses a formula composition for treating paronychia. The formula composition is prepared from the following raw materials in parts by weight: 40-50 parts of raw egg white and 50-60 parts of arrack, the use method of the formula composition for treating paronychia comprises the following steps: S1, material selection: firstly, preparing a part of raw egg white, a part of arrack and a clean preservation bag for later use; s2, mixing: weighing a proper amount of raw egg white and a proper amount of arrack, pouring the weighed raw egg white and arrack into a preservation bag, and uniformly mixing; s3, soaking: soaking the diseased fingers into a fresh-keeping bag, tying an opening of the fresh-keeping bag with a string, sealing the fresh-keeping bag and the legs, soaking for a period of time, and fully soaking the skin around the fingers; s4, airing, namely taking out the diseased fingers from the freshness protection bag and airing; compared with the prior art, cost is saved, pain is relieved, compliance is improved, more importantly, the effect is very good, and the purpose of radical treatment is achieved.

No method for treatment of distant tumor has been reported. A purpose of the present invention is to provide a pharmaceutical composition that is used in combination with radiotherapy to activate immunity against tumor, and that comprises a hydrogen peroxide solution. Another purpose of the present invention is to provide a method for activating immunity against tumor, the method comprising: a step for providing the pharmaceutical composition; a step for administering the pharmaceutical composition to a target site of a patient having the tumor; and a step for irradiating the target site with radiation. The tumor is distant from the target site of the patient having the tumor.

The present invention relates to oral composition and the method of preparation and use of such composition for inhibiting, reducing, and / or disrupting oral biofilm. The composition comprises a stabilizing matrix, a cationic biocide, and a peroxide source.

Agents, kits, and methods that utilize oxygenation to treat Inflammatory Bowel Disease (IBD) and / or provide prophylaxis against exacerbation of IBD are provided. In several embodiments, the agents, kits, and methods according to several embodiments generate in, or carry to, oxygen in the intestinal lumen to treat IBD and provide prophylaxis against exacerbation of IBD, including those caused by the presence of anaerobic bacteria in the intestine. The agents, kits, and methods provided herein generate an aerobic environment within the intestine to alleviate intestinal inflammation.

The invention provides an anti-tumor targeting nano material and a preparation method thereof, and belongs to the field of novel targeting nano drugs. The method comprises the following steps: stirring and mixing up-conversion nanoparticles, calcium peroxide nanoparticles, manganese chloride and a chemotherapeutic drug in a water phase to obtain a drug-loading core; cystamine and 3-aminophenylboronic acid are dissolved in water, EDC and NHS are added, a first amidation reaction is carried out, and a cross-linking agent is obtained; dispersing the drug-loading core in a polyacrylic acid solution, adding a cross-linking agent, and then carrying out a cross-linking reaction to obtain an intermediate product; activating carboxyl on the surface of the intermediate product, and then carrying out second amidation reaction with cRGD-PEG-NH2, so as to obtain the anti-tumor targeting nano material. According to the application, a multifunctional nano platform integrating targeted enrichment, double-response precise drug release, chemotherapy-chemical kinetics-immune collaborative treatment and up-conversion imaging tracing is constructed, and specific efficient killing of tumors and inhibition of metastasis and relapse of the tumors are realized.

A pharmaceutical formulation for topical dental administration or medical (e.g., implant) treatment, including effective amounts of: at least one antimicrobial compound; at least one peroxide source compound; and at least one gel agent. Also disclosed are methods of oral anatomy treatment. The pharmaceutical formulation and treatment methods provide the patient with oral anatomy benefits including, for example, decreased or arrested gum recession; decreased or arrested bone recession; decreased or arrested bone mass loss; decreased or eliminated pain; decreased or eliminated bleeding; decreased or eliminated swelling; enhanced regeneration of bone; enhanced soft tissue repair; or a combination thereof.

A method and system of adaptive cold atmospheric based treatment for diseased tissues, such as an area with cancerous cells, is disclosed. A gas such as helium is ionized via supplying power between and anode and a cathode to create an initial cold atmospheric plasma jet. The initial plasma jet is directed toward the area for a sufficient time, such as 10 seconds, to sensitize the cells via a reactive species. A reactive treatment, such as H2O2 or TMZ, is directed to the sensitized cells. The effectiveness of the reactive treatment is increased by the process of sensitizing the cells.

The present invention relates to a new multifunctional debridement and / or antifouling composition comprising H2O2 at a final concentration of between 0.1 - 5%v / v, and a composite hydrogel formulation comprising pluronic acid at a concentration of 10-40%w / v, wherein the composition is in liquid form at room temperature. The composition disclosed herein is antimicrobial and / or anti-inflammatory and is particular useful in periimplantitis treatment and implant health maintenance, in periodontitis and periodontal health and in wound care and chronic ulcer care.

Mixing a low-viscosity solution and a high-viscosity solution was difficult. An object of the present invention is to provide a holder for mixed administration of at least two types of solutions for enhancing the radiation or anticancer therapeutic effect on a tumor, wherein the holder is capable of simultaneously discharging each solution at a constant ratio from respective syringes containing each solution.

The application provides a metal polyphenol network-wrapped calcium peroxide nanoparticle and a preparation method and application thereof, and belongs to the technical field of tumor treatment. The metal polyphenol network-wrapped calcium peroxide nanoparticle has a protective effect on unstable calcium peroxide nanoparticles; the released metal ions catalyze hydrogen peroxide to generate hydroxyl radicals under acidic conditions, and then kill tumor cells, realize chemical kinetic therapy, can also consume glutathione, enhance the accumulation of active oxygen, and then enhance the anti-tumor effect; when dispersed into an acidic environment, the metal polyphenol network layer thereof can rapidly degrade, expose the calcium peroxide nanoparticles, and then explosively release a large amount of calcium ions and oxygen, which can more effectively activate calcium overload and relieve the tumor hypoxic microenvironment; by loading drugs, the effective accumulation of the drugs in the tumor site is improved, the combined treatment of chemical kinetic therapy and chemotherapy is realized, and thus the anti-tumor immune response is activated, and the anti-tumor effect is improved.

The application provides a magnetic response composite hydrogel for integrated repair of bone defects and a preparation method thereof, and belongs to the technical field of medical materials. The composite hydrogel can efficiently inhibit tumor cell activity under the time sequence regulation of an external alternating magnetic field, and then provide a suitable microenvironment and key components for bone tissue regeneration, so that signal conversion and function connection from tumor killing to bone repair are realized. The material has good injectability and self-healing ability, can minimally invasively fill irregular defects, and has significant advantages in simplifying the clinical treatment procedure, shortening the treatment course, reducing the risk of tumor recurrence and improving the repair quality, and provides a new and integrated treatment strategy for tumor-related bone defects.

The invention relates to the field of auxiliary materials for close-range radiotherapy of gynecological tumors and plasma medicine, in particular to plasma activated mucous membrane coating hydrogel, a preparation method and application. The plasma activated mucous membrane coating hydrogel consists of a hydrogel matrix which can be compatible with mucous membranes and active oxygen nitrogen which is introduced by plasma activation and can be controlled to release under the condition of 37 DEG C, the hydrogel meets the requirement that the apparent release half-life period of active oxygen nitrogen is 0.5-12 hours. The plasma activated mucous membrane coating hydrogel disclosed by the invention integrates lubrication and protection and active oxygen nitrogen mediated repair promotion / anti-inflammatory / antibacterial functions; active oxygen nitrogen short-time controlled release can be matched with fractional treatment; dose perturbation lt; 3%, image positioning is not interfered; the preloaded sheath is discarded when being used, or is smeared as ointment after treatment, and is simple to use.

The invention provides a high-concentration hydrogen peroxide emulsion for treating senile plaques and application thereof, and in the high-concentration hydrogen peroxide emulsion, hydrogen peroxide is used as an active component, can oxidize and decompose melanin in skin, and has a freckle removing effect; the hydrogenated polydecene is used as an emollient, so that the skin can be moistened and the texture of the skin is improved; hydrogenated castor oil (PEG-40) is used as an emulsifier, so that an emulsion system is stable; the bisabolol has anti-inflammatory and soothing effects, and can relieve the irritation of hydrogen peroxide to the skin; citric acid can adjust the pH value of the emulsion, so that the emulsion is more suitable for the physiological environment of skin; sodium hyaluronate has a moisturizing effect and can enhance the barrier function of skin. All the components have a synergistic effect, so that the emulsion has a good senile plaque treatment effect, and meanwhile, irritation to skin is reduced.