19results about "Peroxide active ingredients" patented technology

The application provides a preparation method of oxygen-releasing gelatin for wound healing and application thereof, and relates to the technical field of gelatin preparation.The preparation method comprises the following steps: mixing gelatin with water, adding a mixture of neutral protease and chymotrypsin, carrying out enzymolysis at pH 5.5-6.5 and a temperature of 45-55 DEG C for 10-15 min, inactivating, and obtaining pretreated gelatin by using a dialysis bag with a molecular weight cut-off of 10-15 kDa; mixing the pretreated gelatin with water, adding 30wt%-32wt% hydrogen peroxide solution, stirring, adding 32wt%-34wt% hydrogen peroxide solution, and stirring; continuously adding 30wt%-32wt% hydrogen peroxide solution and stirring; obtaining a crude product; and purifying.The application combines specific enzymolysis pretreatment, an oxidation process and purification to prepare gelatin with better oxygen-releasing capacity, bacteriostatic capacity and significant promotion of skin wound healing, and the gelatin is safe and effective.

The application discloses a rehmannia polysaccharide, a preparation method thereof and application of the rehmannia polysaccharide in preparation of a medicine for preventing and treating kidney injury caused by cisplatin. The rehmannia polysaccharide contains the following monosaccharides in percentage by mass: rhamnose (Rha) 10.265%-14.963%, glucuronic acid (GlcA) 0.514%-0.904%, galacturonic acid (GalA) 35.784%-40.596%, glucose (Glc) 3.128%-5.048%, galactose (Gal) 37.892%-41.438% and arabinose (Ara) 3.869%-4.865%. The structure of the rehmannia polysaccharide is clear, and the rehmannia polysaccharide shows a significant improvement effect on cisplatin nephrotoxicity through cell experiments and animal experiments, and has important value for developing a new and effective prevention and treatment product of cisplatin-induced acute kidney injury.

This invention belongs to the field of biomedical technology, specifically relating to an anti-tumor nanomaterial, its preparation method, and its application. The anti-tumor nanomaterial is formed by in-situ growth of calcium peroxide on the surface of black phosphorus nanosheets to create hierarchical black phosphorus-calcium peroxide nanosheets, followed by coating the surface of these composite nanosheets with hyaluronic acid. After entering tumor cells, the anti-tumor nanomaterial releases calcium ions and hydrogen peroxide, triggering an abnormal increase in calcium ions and oxidative stress within the cells, thereby causing mitochondrial dysfunction and inducing tumor cell death. Simultaneously, the released calcium ions combine with phosphate ions produced by the degradation of black phosphorus, forming calcium phosphate mineralization deposits within the tumor tissue, inducing tumor biocalcification. Changes in calcium signaling and the oxidative stress process can also promote the infiltration and activation of immune cells, thereby regulating the tumor immune microenvironment and achieving a synergistic effect of cell killing, biocalcification induction, and immune regulation within tumor tissue.

This invention relates to the technical field of nanomedicine synthesis and discloses a method for synthesizing nanomedicines for the treatment of rheumatoid arthritis, comprising the following steps: S10: obtaining or preparing high-purity, small-particle-size CaO2 nanoparticles; S20: encapsulating the CaO2 nanoparticles in a ZIF67 system to obtain CaO2@ZIF67; S30: dissolving methotrexate in methanol to obtain an MTX additive solution; dissolving CaO2@ZIF67 in methanol, then adding the MTX additive solution dropwise, and stirring thoroughly; finally, purifying, washing, and drying the obtained product to obtain CaO2@MTX@ZIF67. Targeting the two main pathological features of rheumatoid arthritis, namely inflammation and hypoxic microenvironment, this invention uses ZIF67-loaded calcium peroxide combined with methotrexate to treat the inflammatory sites of rheumatoid arthritis. The constructed product can inhibit the expression of tumor necrosis factor-α / interleukin-6, overcome the hypoxic nature of rheumatoid arthritis, and achieve the technical characteristics of alleviating inflammatory symptoms and altering disease progression, low cost, few side effects, and long-term treatment.

The embodiment of the application discloses an acid-responsive oxygen-releasing chitosan / polycaprolactone core-shell microsphere and a preparation method and application thereof. The microsphere comprises an oxygen-releasing inner core taking polycaprolactone and calcium peroxide as base materials, and a pH-responsive outer shell modified by chitosan through N-acetyl-d-glucosamine and loaded with a natural medicine 6-Gin; the microsphere is disintegrated in the outer shell under the gastric acid environment and rapidly releases 6-Gin, and the inner core continuously releases oxygen by reacting with water. The microsphere provided by the application can effectively inhibit bacterial adhesion, destroy a biofilm and directly kill H. pylori, and solves the problem of poor curative effect caused by a microenvironment in traditional therapy, and provides a new effective strategy for anti-H. pylori therapy.

The present application relates to on-site generated performic acid compositions for teat therapy. The present disclosure relates generally to performic acid forming compositions and methods for forming, preferably in situ, performic acid and the performic acid formed by the compositions and methods for the purpose of treating animal tissue and providing an antimicrobial function on the animal tissue. The present disclosure specifically relates to a residue-free teat therapy composition for treating animal tissue, particularly bovine teats, that provides antimicrobial efficacy and leaves no non-food ingredient residue on the treated teat.

The present invention provides a gel, suppositories, and a method for producing the gel that can compensate for the deficiency of naturally released lactic acid and hydrogen peroxide, lower vaginal pH, and improve the health of the vaginal microbiome. [Solution] The gel contains 50-150 mM concentrated lactic acid and 0.5-10 mM concentrated hydrogen peroxide, and the 50-150 mM concentrated lactic acid and the 0.5-10 mM concentrated hydrogen peroxide are combined.

The present invention identifies AKR1C1 as the first lipedema-associated gene. The invention provides methods for diagnosing or assessing an individual's susceptibility to lipedema by the analysis of the AKR1C1 gene or the expression levels of its product and related metabolites. Also provided are therapeutic methods for treating a patient or methods for prophylactically treating an individual susceptible to lipedema.

This invention discloses a medical material for the prevention and treatment of oral ulcers, its preparation method, and its application. The medical material of this invention comprises a two-dimensional sheet-like nanomaterial composed of an organic matrix and metallic elements. The two-dimensional sheet-like nanomaterial of this invention possesses advantages such as high crystallinity, favorable material transport, high healing rate, reduced recurrence risk, excellent biocompatibility, mild preparation process, scalability, ease of use, and low cost, and has broad application prospects in the field of oral ulcer prevention and treatment.

The application provides a method and a cold mask for rapidly treating cold by traditional Chinese medicine fumigation, and belongs to the fields of traditional Chinese medicine and traditional Chinese medicine materials. The fumigation traditional Chinese medicine composition for treating cold and an oxidizing agent are added into the mask, so that the effective substances of the traditional Chinese medicine composition and the oxidizing agent are gasified in the mask, and the gasification product is used for fumigating the respiratory tract; the drug is targeted to the site, and a very low dosage can kill bacteria, fungi, spores and viruses (including the novel coronavirus) in the respiratory tract, repair the respiratory tract mucosa lesion and improve the human body resistance, so that the cold is rapidly treated; and the single protection function of the existing mask is changed into a protection and treatment dual function.

The present application relates to a kind of multi-component self-assembly injectable hydrogel and its preparation method and application, by rhubarb acid and metal-based nanodot are self-assembled into injectable hydrogel by physical crosslinking.The hydrogel of the present application has the characteristics of shear thinning and reversible crosslinking, can be rapidly delivered to target location by injection mode, and realizes long time local retention;The hydrogel has the ability of long-acting slow-release rhubarb acid molecules and metal-based nanodot, slow-release rhubarb acid can reduce the level of local inflammatory mediators, metal-based nanodot has the effect of scavenging active free radicals, slow-release oxygen supply and promoting osteogenesis, so as to realize the comprehensive treatment of simultaneous regulation of inflammation, relief of oxidative stress and reconstruction of bone repair microenvironment and multiple goals.

This invention discloses a core-shell nanocomposite material prepared by sacrificial template in situ growth and its application in promoting the healing of infected wounds. The present invention is the first to use ZnO2@ZIF-8 as an acid-responsive H2O2 release source to construct a ZnO2@Hemin-ZIF-8@PB composite nanomaterial. This material remains stable in a neutral environment, triggers H2O2 release in the infected microenvironment, and achieves efficient antibacterial and biofilm clearance through the synergistic effect of Hemin / PB-mediated chemical kinetics and Prussian blue (PB) photothermal effect. At the same time, this material can regulate the inflammatory response and promote angiogenesis, thereby accelerating the repair of infected wounds.

The application is suitable for the field of biological medicine technology, and provides a preparation method and application of CAR-T cells loaded with biological calcified nanomaterials, which comprises the following steps: step one, mixing black phosphorus quantum dots, calcium peroxide and lipid components, and purifying by ultrasonic emulsification and ultrafiltration centrifugation to obtain BCLT with mitochondria-targeting molecule triphenylphosphine modified on the surface; step two, co-incubating CAR-T cells with membrane dye after staining, and adding a disulfide bond-containing reduction-responsive linker arm DSPE-S-S-NHS; and step three, co-incubating BCLT with CAR-T cells, so that the BCLT is connected to the surface of the CAR-T cells through a chemical bond to obtain CAR-T cells loaded with biological calcified nanomaterials. The application significantly improves the infiltration capacity and killing effect of the CAR-T cells on solid tumors, can relieve the problem of tumor heterogeneity, and has excellent biological safety and synergistic anti-tumor effect.

This invention discloses a metal-organic framework / calcium peroxide heterojunction composite nanomaterial, its preparation method, and its application. Vanadium (V) is doped into a CoTCPP complex formed by the coordination of tetrakis(4-carboxyphenyl)porphyrin (TCPP) and cobalt (Co) ions via a one-step coordination self-assembly method to construct a V-CoTCPP metal-organic framework matrix. The osteogenic and hypoglycemic functions of V endow the material with additional bioactivity. Based on this, calcium peroxide nanoparticles are loaded onto the V-CoTCPP surface via in-situ precipitation to form an inorganic-organic Janus heterojunction nanoplatform with an asymmetric structure. Under microwave triggering, this platform achieves synergistic functions of microwave thermotherapy-dynamic sterilization, regulation of local glucose metabolism, and promotion of bone tissue repair.

Compositions and methods for treating alopecia, particularly alopecia induced by chemotherapy, using an acidifying agent or oxidant, a prooxidant compound, or an activator of P53. Compositions containing organic peroxides such as cumene hydroperoxide, tert-butyl hydroperoxide (t-BHP), hydrogen peroxide, benzoyl peroxide are preferred. The compositions can be applied subcutaneously, transdermally, or topically. Most preferably, the compositions are applied to the treatment site prior to a series of chemotherapy treatments to prevent or reduce hair loss at the treatment site.

Provided are: a selective antimicrobial agent and / or a selective microbicidal agent containing ozone-treated glycerin, having antibacterial and / or bactericidal actions on harmful microorganisms, and not having antimicrobial and / or microbicidal actions on non-harmful microorganisms; and a selective antimicrobial composition and / or a selective microbicidal composition.

The invention relates to the use of an antibiotic-free antimicrobial feed additive in a method of improving the health of animals and / or reducing methane production of animals. The invention also provides an antimicrobial composition which is used at a low concentration, an antimicrobial composition which has a low ratio of iodide ions to hydrogen peroxide, and uses of these compositions as antimicrobial agents. The invention also provides the use of an antimicrobial composition in combination with an antibiotic as an antimicrobial agent.