107 results about "Wound site" patented technology

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

Standard backing sheets on bandages are made to secure the placement of the absorption pad and to prevent blood from seeping out. With these standard bandages the blood will accumulate in a single area from the wound site. This buildup in a single area will cause more frequent bandage replacements and it can cause seepage issues. The buildup can also cause a more damp and wet feeling for the user.The improved medical bandage backing sheet can prevent this and distribute the blood from a wound site throughout that absorption pad. Utilizing the maximum surface area of that absorption pad or gauze and prevent blood build up in one certain area. In return causing less seepage, a damp feeling to the user, and bandage replacements. The improved backing sheet can also be made with oligodynamic coated threads giving it antimicrobial properties.

The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) formulated in a pullulan hydrogel. The release profile of the FAK inhibitor can be adjusted according to the nature of the wound, e.g., excisional wounds, burn wounds, etc.

A device and related aspects for providing negative pressure to a wound site are disclosed. The device includes: a negative pressure source configured to provide negative pressure to the wound site from an inlet of the negative pressure source via a first fluid flow path; and an electronically controllable valve configured to release negative pressure from the wound site via a second fluid flow path. The device also includes: a pressure sensor configured to measure a pressure level in the second fluid flow path; and a control circuit system operatively connected to the negative pressure source, the electronically controllable valve, and the pressure sensor. The control circuit system is configured to open the electronically controllable valve and, in response to a pressure change rate exceeding a pressure change rate value, output a signal indicating blockage in the second fluid flow path. The control circuit system is further configured to close the electronically controllable valve and activate the negative pressure source in response to a pressure change rate below a pressure change rate value, and to output a signal indicating blockage in the first fluid flow path in response to a pressure level measured by the pressure sensor not responding to changes in negative pressure generated by the activity of the negative pressure source.

The invention belongs to the technical field of medical materials and tissue regeneration engineering, and provides a composite hydrogel prepolymerization solution and application thereof, and composite hydrogel and application thereof. The composite hydrogel pre-polymerization liquid provided by the invention is prepared from the following components in concentration: 5 to 10 w / v percent of methacrylic anhydride gelatin, 1 to 4 w / v percent of methacrylated hyaluronic acid, 0.5 to 1.5 w / v percent of hectorite, 0.5 to 1.5 w / v percent of a photoinitiator and 20 to 100 nmol / L of sphingosine-1-phosphoric acid loaded nano vesicles based on sphingosine-1-phosphoric acid, the nano vesicles are formed by bone marrow-derived macrophages. The composite hydrogel formed by the composite hydrogel pre-polymerization liquid has good biocompatibility and controllable release performance, can form a stable barrier environment on a wound surface, and significantly accelerates the wound surface healing process through the dual effects of immune regulation and revascularization.

Biologic matrices designed to facilitate wound healing and related methods are disclosed. A matrix comprises a three-dimensional, resorbable collagen scaffold derived from a vascularized portion of a perfusion-decellularized mammalian organ or tissue. The scaffold features a porous structure with a plurality of interconnected pores originating from one or more outer surfaces, which are defined by intact vascular pathways of the perfusion decellularized mammalian organ or tissue. The porous configuration substantially enhances the scaffold's effective surface area, making it at least 5 times greater than that of a non-porous scaffold having equivalent outer dimensions. In certain embodiments, the surface area considering the interconnected pores can be 10 times larger, 15 times larger, or more than the non-porous scaffold of equivalent outer dimensions. The density of the scaffold can range from 2 milligrams per cubic centimeter to 20 milligrams per cubic centimeter, inclusive, further optimizing the matrix's performance for wound healing applications.

The utility model discloses a compression hemostasis device acting in the body in the technical field of first-aid hemostasis, which is characterized in that a hemostasis bag is added, a hemostasis tube is connected with the hemostasis bag, the hemostasis bag can extend into the body of a patient and can be pressurized and expanded to perform compression hemostasis on a wound part in the body, and a hemostasis clamping piece is added outside, so that the hemostasis effect is good. The hemostasis device can be attached to the in-vitro skin, compression hemostasis is carried out on the body surface through the hemostasis clamping piece, meanwhile, the hemostasis clamping piece and the hemostasis bag can be clamped inside and outside, a body surface bleeding opening is clamped and blocked, and effective hemostasis is carried out on a bleeding point through the inner layer and the outer layer. In addition, the blood collection tube is additionally arranged for observing the bleeding amount, bleeding spots can be located more quickly, the bleeding duration is shortened, and time is won for follow-up treatment.

The invention discloses composite hydrogel based on hyaluronic acid as well as a preparation method and application of the composite hydrogel, and belongs to the technical field of hydrogel. In order to deal with ROS (reactive oxygen species) amplified at a radiation injury part and regulate and control an inflammatory environment at a wound part, natural polyphenol epigallocatechin gallic acid (EGCG) with outstanding oxidation resistance is introduced into a system, and the composite hydrogel based on hyaluronic acid is synthesized.

This invention provides an antibacterial and repair-promoting piezoelectric film, its preparation method, and its application, belonging to the field of piezoelectric material technology. The method involves in-situ self-assembly of Fe-MOF on the surface of BTO, followed by further loading with DHA to synthesize an electrically controlled drug-release, antibacterial, and repair-promoting nanocomposite, BTO / Fe-MOF / DHA. BTO / Fe-MOF / DHA is then added to the surface of semi-cured PDMS to form an antibacterial and repair-promoting piezoelectric film, PDMS-BTO / Fe-MOF / DHA. When the PDMS-BTO / Fe-MOF / DHA piezoelectric film is subjected to ultrasonic stimulation, BTO converts mechanical energy into electrical energy, releasing Fe from the Fe-MOF... 3+ Reduced to Fe 2+ Fe-MOF degrades and releases DHA, and ultimately, Fe... 2+ Reacting with synchronously released DHA, it produces a large amount of toxic ROS, which damages proteins and nucleic acids, inducing bacterial death. The antibacterial and repair-promoting piezoelectric membrane of the present invention generates a piezoelectric potential during mechanical deformation caused by animal movement and induces EF at the wound site to promote wound healing. This antibacterial and repair-promoting piezoelectric membrane shows great potential in the future treatment of bacterial infected wounds.

The application relates to a kind of dosing device for mupirocin ointment, relate to medical instrument technical field, it includes storage part, connecting part and extrusion part, storage part includes chute sleeve and storage box slidably arranged in chute sleeve, storage box is used to store mupirocin ointment in;Connecting part includes connecting ring, the two ends of connecting ring are respectively with the detachable link of storage part and extrusion part, the bottom of gauze can be contacted with mupirocin ointment in storage box when storage box vertically moves upward;Extrusion part includes fixed shell and extrusion assembly arranged in the inside of fixed shell, extrusion assembly is used to apply pressure to gauze, and gauze is adhered at wound site;Temperature adjusting assembly for heating or cooling extrusion assembly is arranged in extrusion part, and hot compress or cold compress of wound is realized.The application has the effect of evenly applying mupirocin ointment on wound site while alleviating patient's discomfort, improving the recovery efficiency of wound.

Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The application provides a kind of injectable responsive hydrogel loaded with chitosan oligosaccharide-gallic acid octyl ester and its preparation method and application, and the preparation method comprises: chitosan oligosaccharide-gallic acid octyl ester conjugate is added into carboxymethyl chitosan solution to obtain a mixed solution;The mixed solution and the oxidized tannic acid solution are mixed to form an injectable responsive hydrogel.The three-dimensional hydrogel network formed by carboxymethyl chitosan and oxidized tannic acid is constructed, chitosan oligosaccharide-gallic acid octyl ester is stably loaded in the gel system, can form a physical barrier in the local wound and provide sustained support, thereby significantly improving the retention capacity of antibacterial components in the wound site, prolonging its effective action time, reducing the need for repeated administration.Effectively solve the problem that antibacterial functional materials are difficult to stay in humid infected wounds for a long time and are easy to lose with exudate, can be applied and prepared into antibacterial drugs.

The application provides a hyaluronic acid-based hydrogel for biological orthogonal cross-linking and a preparation method and application thereof, and belongs to the field of chemical synthesis and biomedical technology. The hyaluronic acid-based hydrogel is obtained by cross-linking a hydrogel main body structure shown in formula 1 and a synthesized cross-linking agent shown in formula 2. The application also provides application of the hyaluronic acid-based hydrogel in preparation of a drug for treating bacterial infection wound healing. The hyaluronic acid-based hydrogel has excellent bioluminescence performance and can detect the strength of inflammation at a wound site. The prepared hydrogel material has the effects of sonodynamic therapy, secondary treatment, antibacterial and wound healing.

An apparatus and related aspects for providing reduced pressure to a tissue site are disclosed. The apparatus comprises a source of negative pressure configured to provide negative pressure via a first fluid flow path from an inlet of the source of negative pressure to a wound site, power supply circuitry comprising a power source, the power supply circuitry being configured to provide a supply voltage to the source of negative pressure, and a pressure sensor arranged to monitor a pressure level in a fluid flow path that is in fluid connection with the wound site. The apparatus further comprises control circuitry operatively connected to the source of negative pressure, the pressure sensor, and the power supply circuitry. The control circuitry is configured to in response to a pressure change rate as detected by the pressure sensor being below a pressure change rate threshold while the source of negative pressure is active, set the supply voltage to the source of negative pressure to a first voltage value above a nominal voltage value.

The utility model relates to the technical field of auxiliary treatment tools, and particularly discloses an elastic glove for preventing scar hyperplasia after burn, which comprises a glove main body, the glove main body comprises a palm part and a fingerstall part, and one end of the fingerstall part is provided with the palm part and a tension reducing mechanism; the tension reducing mechanism comprises a stretching notch formed in the palm part and a traction strip arranged in the stretching notch, and one end of the traction strip is connected with a traction piece; according to the device, the glove body can be longitudinally separated by arranging the separating zipper, at the moment, a patient can stretch the hand into the glove, the double-sided adhesive tape is bonded to the two ends of a wound part respectively, and after the glove body is worn, the two sets of traction strips exposed out of the palm part are pulled in the opposite outer side directions respectively; at the moment, the double-sided adhesive tape at the other end of the traction strip can be pulled inwards at the same time, so that the wound part can be extruded, and an effective tension reducing effect can be provided for the wound.

The utility model discloses a urinary nursing drainage anti-folding device which comprises a limiting sleeve arranged on the surface of a urinary catheterization drainage tube in a sleeved mode, and a plurality of fixing pieces which are annularly distributed at equal intervals and used for limiting the drainage tube are arranged in an inner cavity of the limiting sleeve. An adjusting piece for driving the fixing pieces to synchronously contract or expand is movably arranged on the outer surface of the limiting sleeve in a threaded manner; the multiple fixing pieces can be driven to move synchronously by rotating the adjusting piece, the drainage tube can be fixed, the near end of the drainage tube at a wound can be supported and protected, the phenomenon that the drainage tube is bent or disengaged due to traction and pulling is avoided, the drainage tubes with different diameters can be fixed, and the drainage tube fixing effect is improved. The application range of the urinary nursing drainage anti-folding device is widened, a spring structure does not need to be adopted, the clamping effect on the drainage tube can be improved, the phenomenon of structural failure is avoided, the number of steps for fixing the drainage tube can be reduced, and it is avoided that an adhesive tape needs to be wound and pasted on the protective sleeve for fixing in the follow-up process.

The application discloses a self-powered electroactive dressing with a wound repair function and a preparation method and application thereof, and belongs to the technical field of medical devices. The electroactive dressing comprises a zinc-molybdenum primary battery structure and three layers of functionalized nanofiber scaffolds. The scaffold takes gelatin-polycaprolactone as a fiber matrix, sequentially loads zinc nanoparticles, icariin and molybdenum nanoparticles to form a functional layer, and is prepared through EDC / NHS cross-linking modification. The electroactive dressing has good mechanical properties and biocompatibility, can be minimally invasively implanted in a wound site, spontaneously generates a continuous and stable microelectric field through the zinc-molybdenum primary battery, and cooperatively realizes gradient-controlled release of icariin from burst release to sustained release, so that the effects of promoting fibroblast proliferation and migration and promoting rapid wound healing are achieved. The dressing has the advantages of simple preparation process, low cost, active regulation of a wound microenvironment, mild and controllable degradation, safety, no toxic side effects, and a very good application prospect.

The utility model relates to the technical field of apical surgery, in particular to an in-vitro compression hemostasis device for apical surgery, which comprises placing cloth, adjustable elastic ropes are fixedly mounted on four sides of the placing cloth, an ice bag is arranged on one side of the placing cloth, gauze is wound on the outer sides of the placing bag and the ice bag, and the gauze is wound on the outer side of the placing cloth. A medical proof fabric is adhered to the interface of the gauze; according to the scheme, the placing cloth and the four adjustable elastic ropes are arranged, the ice bag can be placed on one side to wrap the ice bag, so that a patient can wear the ice bag conveniently, tight attachment of the ice bag and proper pressure can directly act on a bleeding part, the blood flow speed is reduced, platelet aggregation at a wound is promoted, thrombus is formed, bleeding is effectively stopped, and the patient can be prevented from being injured. The ice bag can be tightly attached to the body of a patient through the adjustable elastic rope and is not prone to slipping or shifting, and the wearing comfort and stability are improved.

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

This invention discloses a wound dressing with photothermal antibacterial, hemocoagulant-promoting, and easily removable properties, its preparation method, and applications, belonging to the field of biomaterials technology. The method includes dissolving sericin in water, then sequentially adding hemoglobin, carbodiimide, and N-hydroxysuccinimide to induce a cross-linking reaction; obtaining a precursor for the composite protein dressing through a mechanochemical cross-linking strategy; pre-cooling the precursor and freeze-drying it to obtain a sericin-hemoglobin dressing; dialyzing the sericin-hemoglobin dressing in water for 2-3 days, and freeze-drying it again to obtain a protein dressing containing only hemoglobin and sericin. The antibacterial dressing prepared by this invention, upon contact with blood, promotes the formation of a dense fibrin membrane, promoting hemostasis while making it easy to remove from the wound site. This wound dressing is entirely composed of protein, exhibits good biocompatibility, and has great development potential.

The application provides a multifunctional microalgae-based hydrogel wound dressing and a preparation method and application thereof, and belongs to the field of hydrogel dressings. Microalgae are embedded in a hydrogel network formed by modified gelatin and cross-linked sodium alginate, and a multifunctional alginate hydrogel is constructed for chronic wound repair of diabetes. The selected microalgae can realize in-situ synthesis and uniform distribution of small-sized gold nanoparticles on the surface thereof during co-culture with high-concentration gold ions, stimulate high-efficiency secretion of extracellular polysaccharides by the microalgae, and maintain high cell activity. The prepared dressing is helpful for relieving a local hypoxic microenvironment of a wound and promoting vascular regeneration, can effectively remove excess active oxygen at a wound site, and can induce macrophages to polarize to M2 type; in addition, the gold nanoparticles in the hydrogel network have good antibacterial performance.

A disposable adhesive bandage capable of identifying the presence of Staphylococcus aureus (“S. aureus”) at a wound site. By utilizing elements of existing rapid tests, a standard adhesive bandage can be upgraded to detect S. aureus or a proprietary bandage could be manufactured containing the necessary components for such detection without detracting from the bandage's primary capabilities of protecting and covering a wound site. In another embodiment, the bandage pad is manufactured to perform the steps of the testing surfaces.

The invention discloses a composition for skin wound regeneration and repair and a preparation method and application thereof. A monatomic transition metal modified photocatalytic material is constructed, selective oxidation and inactivation of a damage-related molecular mode are realized, and a mediated inflammation signal channel is accurately inhibited, so that the immune homeostasis of a wound part is reconstructed, and tissue repair is promoted. Through monatomic active site construction, electronic structure regulation and control and photon-generated carrier behavior optimization, the photocatalytic material can stably generate selective oxidation capacity under the physiological illumination condition, and the continuous functions of anti-inflammation and tissue regeneration are achieved.

This invention discloses a gel formulation containing human platelet-derived growth factor (PDGF). The components and dosages are as follows: PDGF 50,000-300,000 IU / mL, sodium carboxymethyl cellulose 3.0-4.5%, polyvinyl alcohol 0.5-3%, disodium hydrogen phosphate dodecahydrate 0.258-0.774%, sodium dihydrogen phosphate monohydrate 0.039-0.116%, sodium chloride 0.6-0.95%, methylparaben 0.15-0.18%, propylparaben 0.015-0.020%, and protein protectant 0.4-0.6%. This invention, through optimization of the gel matrix combination and ratio, enables the gel to possess excellent stability and skin adhesion, improves the biological activity of the formulation, and promotes cell proliferation and wound repair at the wound site. It also offers advantages such as a pleasant user experience and simple processing.

The invention relates to the technical field of nursing devices, in particular to a local burn part overhead nursing protection frame for burn patients, which comprises a protection sleeve, an emptying groove is formed in the protection sleeve, and two supporting rings are symmetrically and fixedly connected to two ends in the protection sleeve. The shank is placed through the two supporting rings, the wound part is forced to be placed above the empty groove, it can be guaranteed that the wound is not contacted, compression is prevented, the air bag ring and the protective air curtain are forced to expand through the micro high-pressure air pump, the fixed position of the shank is flexibly wrapped and fixed, and serious discomfort caused by rigid connection is prevented; the connecting pipe is used for receiving airflow flowing out continuously from the empty groove, the fan blades are blown to drive the rotating shaft to rotate, the gear ring can be driven to rotate, the connecting box is forced to drive the massage head to rotate in the annular groove, the fixed position of the shank can be massaged continuously and automatically, work is convenient, and discomfort is further relieved.

A system, apparatus and method for delivering negative pressure and vibrations proximate a wound site. The system comprises a dressing adapted to be fluidly coupled to the wound site and further adapted to translate vibrations to the wound site. A pad is coupled to a negative pressure source and to the dressing. The pad is also coupled to a vibration module. The system further comprises a drape covering the dressing and the pad and forming a seal between the wound site and the environment. The vibration module fluidly couples to the dressing and provides vibrations during application of negative pressure.

This invention discloses a bone repair scaffold system for tumor early warning and non-invasive treatment, comprising a bone repair scaffold, a microenvironment monitoring RFID module, a controlled drug release module, a signal reading system, and a cloud processor. The bone repair scaffold is shaped to fit the wound site and has a porous internal structure. The microenvironment monitoring RFID module is disposed on the internal and external surfaces of the bone repair scaffold. The controlled drug release module includes a microwave induction module and a drug storage unit. An external microwave excitation causes the microwave induction module to heat up, stimulating the thermoresponsive drug storage unit to release the drug. The signal reading system communicates with the microenvironment monitoring RFID module via radio frequency and is interconnected with the cloud processor via the internet. This invention can promote bone repair while rapidly monitoring tumor recurrence, alerting patients to seek medical attention early. Simultaneously, the drug release module enables non-invasive treatment, reducing patient suffering, improving quality of life, and prolonging survival.

The present invention relates to a gel composition for wound dressing comprising alloferon as an active ingredient, wherein the composition comprises alloferon having excellent anti-inflammatory activity, and further comprises additional components capable of forming a physical barrier on damaged skin tissue to protect a wound site and to provide and retain moisture. The composition of the present invention protects a wound site vulnerable to ultraviolet radiation, alleviates inflammation, and prevents destruction of elastic fibers in the skin and epidermal hyperplasia. Accordingly, the composition can be advantageously utilized as a gel composition for wound dressing to prevent, ameliorate, alleviate, or treat skin inflammation induced by ultraviolet radiation.

The invention belongs to the technical field of medical instruments, and particularly discloses an operating room nursing tourniquet winding device which comprises a holding piece and side plates clamped to the two sides of the holding piece, a tourniquet body penetrates through a cavity formed by the holding piece and the side plates, and a first extrusion rod and a second extrusion rod slidably penetrate through the holding piece. The second extrusion rod is used for extruding the tourniquet body so that the tourniquet body can conveniently wind the wound part of a patient, a cutter is fixed to the position, located on one side of the first extrusion rod, of the inner wall of the holding piece, and when the first extrusion rod extrudes the tourniquet body, the cutter cuts the tourniquet body. When a medical worker winds a tourniquet body on a wound part of a patient through the winding device, the tourniquet winding habit of the medical worker is met, meanwhile, the cutter in the winding device can cut the right end of the tourniquet body, and the medical worker can conveniently cut the tourniquet body to the proper using length according to patients of different body types.