194 results about "Wound site" patented technology

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. A novel platinum catalyst comprising platinum tetramethyldivinyl disiloxane diethyl maleate complex for use in such compositions provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The invention discloses a preparation method and application of a novel hybrid extracellular vesicle. According to the invention, vesicles derived from endothelial cells and neutrophil cells are combined with deferoxamine, and a biological mixed nano vesicle platform (DFO (HEVS)) is developed to solve the problem of diabetes wound healing. According to the dual-targeting system, DFO is accurately delivered to a wound part by utilizing CXCR4 mediated endothelial cell homing and beta2 integrin dependent inflammation tropism, DFO (at) HEVs activates and recovers vascular regeneration through HIF-1alpha / VEGF, ferroptosis is inhibited through Nrf2 / GPX4 signal transduction, macrophages are reprogrammed into a repair promoting M2 phenotype, and oxidative stress-inflammation-ferroptosis circulation is effectively broken.

The invention provides a life support stretcher. The life support stretcher is internally provided with a controller and an air bag pressurization binding belt used for binding the wounded, wherein a vital sign data detection unit is arranged in the air bag pressurization binding belt; the life promotion data specifically comprises heart rate, breathing parameters, blood pressure, body temperature and oxyhemoglobin saturation; the controller is used for controlling the air pressure in the air bag pressurization binding belt according to the vital sign data, detected by the vital sign data detection unit, of the wounded, and dynamically adjusting the binding tightness degree through a multi-modal data fusion algorithm and wound part recognition. Thus, when the life support stretcher is used for transferring a wounded person, the air bag pressurization binding belt can be used for binding the wounded person, the vital sign data of the wounded person can be detected through the vital sign data detection unit in the air bag pressurization binding belt, and then the controller can control the wounded person according to the detected vital sign data. And the air pressure in the air bag pressurizing binding belt is controlled, so that the trauma to the wounded caused by bumping is reduced.

The application discloses a light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme, a preparation method and application, and belongs to the technical field of biomedical materials. In the application, spherical silica nanoparticles are used as a template, and a structure of copper ion-polydopamine coated silica nanoparticles is formed on the surface of the silica nanoparticles through self-polymerization of dopamine and chelation of copper ions, and the spherical structure is maintained with the support of the silica nanoparticles. The copper ion-polydopamine coated silica nanoparticles are pyrolyzed to obtain a copper-based single-atom nanoscale enzyme with a carbon skeleton, and a hollow spherical single-atom nanoscale enzyme is obtained after etching. Nitric oxide donor molecules are loaded into the hollow of the hollow spherical single-atom nanoscale enzyme to obtain the light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme. The application can realize the synergistic treatment effect of photothermal therapy, nitric oxide gas therapy and biological catalytic therapy, is used for efficiently removing bacteria and biofilms at an infected wound site, and effectively promotes the healing of the bacteria-infected wound.

Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

An osmotic bandage for treating wounds, such as cuts, abrasions, minor burns, blisters, and post-surgical incisions. The bandage includes a bandage strip with an adhesive along with a plurality of apertures or airholes disposed therethrough for breathability. The bandage further includes a multi-layered gauze pad. The multi-layered gauze pad includes a first layer, a second salt laced layer, and a third odor-reducing layer. The salt is a natural bactericide, through the dehydration of water in bacteria, and kills any bacteria that attempt to invade or enter the wound site. A semi-permeable membrane cover may be disposed in overlying relation to the pad to prevent the salt from being in direct contact with the wound tissue and causing the patient pain.

The invention relates to a hydrogel light-operated multi-mode synergistic treatment platform based on a CuxS-MoS2 heterojunction for promoting wound healing of diabetes mellitus. And an interface induced electric field strategy is provided through density functional theory (DFT) calculation to optimize the charge migration behavior of the phototherapy agent. The multifunctional phototherapy system is constructed by taking CuxS-MoS2 with a built-in electric field as a core and PVA-CS hydrogel loaded with glucose oxidase (GOx) as a bracket. In a weakly acidic wound microenvironment, glucose at the wound is catalyzed by GOx to be converted into H2O2 and gluconic acid; meanwhile, the CuxS-MoS2 remarkably enhances the generation of reactive oxygen species (ROS) under illumination through peroxidase-like (POD) activity, photothermal effect (PTT) and heterojunction efficient carrier separation. After entering a proliferation period, the stent exerts catalase-like (CAT) activity to remove excessive ROS and release oxygen, and oxygen deficit and oxidative stress are relieved. In addition, the controllably released copper ions regulate and control the behavior of fibroblasts, promote healing and inhibit fibrosis. Experiments prove that the stent has excellent biocompatibility, effective antibacterial property and remarkable healing promoting effect in chronic wound repair of diabetes mellitus.

Standard backing sheets on bandages are made to secure the placement of the absorption pad and to prevent blood from seeping out. With these standard bandages the blood will accumulate in a single area from the wound site. This buildup in a single area will cause more frequent bandage replacements and it can cause seepage issues. The buildup can also cause a more damp and wet feeling for the user.The improved medical bandage backing sheet can prevent this and distribute the blood from a wound site throughout that absorption pad. Utilizing the maximum surface area of that absorption pad or gauze and prevent blood build up in one certain area. In return causing less seepage, a damp feeling to the user, and bandage replacements. The improved backing sheet can also be made with oligodynamic coated threads giving it antimicrobial properties.

The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) formulated in a pullulan hydrogel. The release profile of the FAK inhibitor can be adjusted according to the nature of the wound, e.g., excisional wounds, burn wounds, etc.

This invention discloses a method for preparing a composite spray that improves hemostasis at wound sites. The composite spray includes solution A and solution B, where solution B is an aqueous solution of sodium alginate. The preparation method of solution A includes: 1. Dissolving a lipopeptide conjugate, cholesterol, distearylphosphatidylcholine, distearylphosphatidylserine, and dimethyl sulfoxide in a chloroform-methanol mixed solution to obtain a mixed system; 2. Preparing a precursor solution from the mixed system using a thin-film hydration method; 3. Adding calcium chloride to the precursor solution and reacting it in the dark to obtain solution A. This invention designs the precursor solution based on the function of natural platelets, and its function is equivalent to that of nanoplatelets. Combined with sodium alginate, it can specifically alleviate the adverse effects on the coagulation system caused by blood loss, such as fibrin degradation and reduced platelet activation, at wound sites. It has the characteristics of rapid hemostasis, good bioactivity, and rapid wound healing.

The utility model discloses an animal limb operation strapping device, which belongs to the technical field of strapping hemostasis and comprises a limb sheath. A plurality of ribbons which are arrayed in the circumferential direction and are not connected with one another are connected to the upper portion of the limb sheath, a threading hole is formed in the end of each ribbon, and all the ribbons can be fastened together by penetrating binding belts into the threading holes; dense anti-licking puncture parts are fixed on the side surface of each ribbon from inside to outside in a penetrating manner, and the dense anti-licking puncture parts are like thorns on a hedgehog body. The binding device is used for binding and stopping bleeding at amputation or amputated limb during animal operation, a bandage is bound at a wound firstly, then the limb sheath is sleeved on the outer side of the bandage, and due to the fact that the anti-licking puncture part on the side face of the bandage is like a thorn on a hedgehog, animals can be effectively prevented from licking or scratching the bandage at the wound, so that the bandage is prevented from falling off, and the wound is prevented from being infected.

The invention relates to the technical field of biological materials, and discloses a liquid dressing and a preparation method thereof, and the liquid dressing comprises a lipid phase and a water phase; the lipid phase comprises lecithin, glyceryl dioleate, polysorbate and an organic solvent; the water phase comprises hyaluronic acid or a salt thereof and a buffer solution, the molecular weight of the hyaluronic acid or the salt thereof is 500-5000Da, and the mass ratio of the hyaluronic acid or the salt thereof to lecithin is (0.05-0.2): 10. The mode of combining the lipid phase and the water phase is adopted, all components in the lipid phase and the water phase have a synergistic effect, free hyaluronic acid or salt thereof is released while the carrier transports hyaluronic acid or salt thereof, the free hyaluronic acid or salt thereof preferentially reaches an action target spot, and then the hyaluronic acid or salt thereof is slowly released under the carrier effect of the lipid phase, so that the hyaluronic acid or the salt thereof is slowly released. According to the present invention, the long-term and lasting protection on the wound part is achieved, the rapid release and slow release combined purpose is achieved, the in vivo immune system is enhanced, the overall cell inflammatory factor level in the body is significantly reduced, and the rapid and continuous pain relieving effect is achieved.

The present invention discloses a formulation of curcumin basedpowder spray that includes 95% Curcuma longa 2-6 %w / w, isopropyl myristate 01-0.2 %w / w, Aluminum Starch Octynyl Succinate 3-7 %w / w, n-pentane 18.7-22.7 %w / w and propellant 68-72 %w / w. Also disclosed is a process for preparation of the formulation of curcumin based antiseptic powder spray. This powder spray of the present invention is applied by spraying the same from an aluminum can directly on to a wound site to provide antiseptic protection without physically touching the wound. The powder spray is enhanced with the healing properties of turmeric (Curcuma longa), forming a protective layer on the wound site, effectively treating deep wounds, cuts, and abrasions from infections.

Apparatus and methods for a therapeutic boot that promotes the healing of pressures sores is described. Bedridden patients are prone to developing pressure sores over bony prominences of the foot such as a heel. The therapeutic boot includes a sides-down, open door design that provides unobstructed access to a wound site. The therapeutic boot may be designed to offload the patient's heel and bony prominences on both sides of the patient's ankle. The therapeutic boot is designed such that opening and closing the boot does not apply pressure and or friction to the wound site.

The embodiment of the application discloses a kind of prediction method, device and equipment of wound healing process, the method comprises: obtaining target image sequence;Using the first module of pre-trained prediction model, respectively on each target image in the target image sequence Local feature extraction and global feature extraction processing are carried out, to obtain local feature vector and global feature vector;Using the second module of the pre-trained prediction model, based on different preset extraction period, respectively on the local feature vector and the global feature vector Time series feature extraction processing is carried out, to obtain multiple time series feature vectors;Using the pre-trained prediction model, based on the multiple time series feature vectors, generate healing condition prediction information for the wound site;According to the healing condition prediction information, determine treatment plan.

Disclosed herein are low density particles comprising polymerized fibrin that are micrometer or nanometer sized in diameter. The particles can further include at least one therapeutic agent. The particles may be used to treat wounds, by administration directly or systemically to the site of the wound. Exemplary wounds that may be treated with the fibrin particles include a trauma wound, a surgical wound, a burn wound, or an ulcer wound. Also disclosed herein are methods for preparing the particles using a shearing process.

The invention provides a non-dissolution type antibacterial dressing and a preparation method thereof, and relates to the technical field of medical dressings. A non-dissolution type antibacterial dressing comprises a base material, micron-sized antibacterial microspheres and an endotoxin adsorption material, and the antibacterial microspheres and the endotoxin adsorption material are loaded inside and / or on the surface of the base material in one or more modes of physical wrapping, physical winding and chemical bond connection; the base material comprises polyvinyl alcohol fibers and / or chitosan sponge; the endotoxin adsorption material comprises modified styrene divinyl benzene affinity resin nano-structure particles and / or poly (4-methyl-1-pentene) fibers. The antibacterial microspheres can effectively kill bacteria at wounds and inhibit growth and reproduction of the bacteria, the endotoxin adsorption material has strong adsorption capacity, inflammatory response caused by endotoxin is reduced, the risk of wound infection is reduced, the antibacterial microspheres and the endotoxin adsorption material are mutually synergistic in performance, the antibacterial performance is excellent, wound adhesion is avoided, the risk of wound infection is reduced, and the wound healing effect is good. The wound healing is promoted.

A device and related aspects for providing negative pressure to a wound site are disclosed. The device includes: a negative pressure source configured to provide negative pressure to the wound site from an inlet of the negative pressure source via a first fluid flow path; and an electronically controllable valve configured to release negative pressure from the wound site via a second fluid flow path. The device also includes: a pressure sensor configured to measure a pressure level in the second fluid flow path; and a control circuit system operatively connected to the negative pressure source, the electronically controllable valve, and the pressure sensor. The control circuit system is configured to open the electronically controllable valve and, in response to a pressure change rate exceeding a pressure change rate value, output a signal indicating blockage in the second fluid flow path. The control circuit system is further configured to close the electronically controllable valve and activate the negative pressure source in response to a pressure change rate below a pressure change rate value, and to output a signal indicating blockage in the first fluid flow path in response to a pressure level measured by the pressure sensor not responding to changes in negative pressure generated by the activity of the negative pressure source.

The invention belongs to the technical field of medical materials and tissue regeneration engineering, and provides a composite hydrogel prepolymerization solution and application thereof, and composite hydrogel and application thereof. The composite hydrogel pre-polymerization liquid provided by the invention is prepared from the following components in concentration: 5 to 10 w / v percent of methacrylic anhydride gelatin, 1 to 4 w / v percent of methacrylated hyaluronic acid, 0.5 to 1.5 w / v percent of hectorite, 0.5 to 1.5 w / v percent of a photoinitiator and 20 to 100 nmol / L of sphingosine-1-phosphoric acid loaded nano vesicles based on sphingosine-1-phosphoric acid, the nano vesicles are formed by bone marrow-derived macrophages. The composite hydrogel formed by the composite hydrogel pre-polymerization liquid has good biocompatibility and controllable release performance, can form a stable barrier environment on a wound surface, and significantly accelerates the wound surface healing process through the dual effects of immune regulation and revascularization.

Biologic matrices designed to facilitate wound healing and related methods are disclosed. A matrix comprises a three-dimensional, resorbable collagen scaffold derived from a vascularized portion of a perfusion-decellularized mammalian organ or tissue. The scaffold features a porous structure with a plurality of interconnected pores originating from one or more outer surfaces, which are defined by intact vascular pathways of the perfusion decellularized mammalian organ or tissue. The porous configuration substantially enhances the scaffold's effective surface area, making it at least 5 times greater than that of a non-porous scaffold having equivalent outer dimensions. In certain embodiments, the surface area considering the interconnected pores can be 10 times larger, 15 times larger, or more than the non-porous scaffold of equivalent outer dimensions. The density of the scaffold can range from 2 milligrams per cubic centimeter to 20 milligrams per cubic centimeter, inclusive, further optimizing the matrix's performance for wound healing applications.

The utility model discloses a compression hemostasis device acting in the body in the technical field of first-aid hemostasis, which is characterized in that a hemostasis bag is added, a hemostasis tube is connected with the hemostasis bag, the hemostasis bag can extend into the body of a patient and can be pressurized and expanded to perform compression hemostasis on a wound part in the body, and a hemostasis clamping piece is added outside, so that the hemostasis effect is good. The hemostasis device can be attached to the in-vitro skin, compression hemostasis is carried out on the body surface through the hemostasis clamping piece, meanwhile, the hemostasis clamping piece and the hemostasis bag can be clamped inside and outside, a body surface bleeding opening is clamped and blocked, and effective hemostasis is carried out on a bleeding point through the inner layer and the outer layer. In addition, the blood collection tube is additionally arranged for observing the bleeding amount, bleeding spots can be located more quickly, the bleeding duration is shortened, and time is won for follow-up treatment.

This invention relates to a composite tissue adhesive and its application in hemostasis, sterilization, and wound healing promotion. The adhesive comprises component A and component B. Component A includes: methacrylic anhydride-modified gelatin, dodecaldehyde-modified chitosan, polycaprolactone / methacrylic anhydride-modified gelatin blended nanofibers, a photosensitive crosslinking agent, and water. Component B is an aqueous solution of an amino crosslinking agent. In use, components A and B are mixed, injected into the wound, and irradiated with ultraviolet or blue light. The tissue adhesive of this invention is injected directly into the wound site in liquid form. Upon light irradiation, it forms a gel structure in situ with a strength comparable to that of skin, simultaneously providing hemostasis, sterilization, and wound healing promotion.

The invention discloses composite hydrogel based on hyaluronic acid as well as a preparation method and application of the composite hydrogel, and belongs to the technical field of hydrogel. In order to deal with ROS (reactive oxygen species) amplified at a radiation injury part and regulate and control an inflammatory environment at a wound part, natural polyphenol epigallocatechin gallic acid (EGCG) with outstanding oxidation resistance is introduced into a system, and the composite hydrogel based on hyaluronic acid is synthesized.

A wound irrigation system includes a first fluid including an ion rich compound having free available ions; and a second fluid including an oxidation-reduction potential increasing compound, the second fluid housed separately from the first fluid. Mixing the first and second fluids in a charging area forms an ionically charged fluid with an oxidation-reduction potential higher than a wound site oxidation-potential. The ionically charged fluid increases antimicrobial activity of the wound upon application.

Featured are impact detection sensors that include a nonconductive layer disposed between two conductive layers. Each conductive layer includes an electrical circuit configured to generate a signal in response to an impact. Also featured are devices (e.g., a wearable device or device configured for use with a piece of equipment, such as a vehicle) including a plurality of impact detection sensors. The device having sensors can receive and process data from the sensors and provide situational awareness for users in adverse conditions, such as during combat or wartime. The wearable device may further include one or more inflatable bladders configured to apply pressure to a wound site for treatment.

This invention provides an antibacterial and repair-promoting piezoelectric film, its preparation method, and its application, belonging to the field of piezoelectric material technology. The method involves in-situ self-assembly of Fe-MOF on the surface of BTO, followed by further loading with DHA to synthesize an electrically controlled drug-release, antibacterial, and repair-promoting nanocomposite, BTO / Fe-MOF / DHA. BTO / Fe-MOF / DHA is then added to the surface of semi-cured PDMS to form an antibacterial and repair-promoting piezoelectric film, PDMS-BTO / Fe-MOF / DHA. When the PDMS-BTO / Fe-MOF / DHA piezoelectric film is subjected to ultrasonic stimulation, BTO converts mechanical energy into electrical energy, releasing Fe from the Fe-MOF... 3+ Reduced to Fe 2+ Fe-MOF degrades and releases DHA, and ultimately, Fe... 2+ Reacting with synchronously released DHA, it produces a large amount of toxic ROS, which damages proteins and nucleic acids, inducing bacterial death. The antibacterial and repair-promoting piezoelectric membrane of the present invention generates a piezoelectric potential during mechanical deformation caused by animal movement and induces EF at the wound site to promote wound healing. This antibacterial and repair-promoting piezoelectric membrane shows great potential in the future treatment of bacterial infected wounds.