282 results about "Wound site" patented technology

The invention discloses a rapid hemostasis powder material for massive hemorrhage. The rapid hemostasis powder material for massive hemorrhage is tannic acid modified carboxymethyl chitosan. The invention also provides a preparation method and application of the rapid hemostasis powder material for massive hemorrhage, and a rapid hemostasis microgel composition containing the rapid hemostasis powder material for massive hemorrhage. The rapid hemostasis powder material and microgel composition for massive hemorrhage have excellent water solubility, hemostasis performance and biocompatibility, have multiple effects of sterilization, anti-inflammation, wound healing promotion and the like, and are beneficial to rapid healing of wound parts after hemostasis.

The invention discloses a polyphenol-based tissue adhesive for promoting wound healing and a preparation method thereof, and relates to the technical field of medical tissue adhesives. The preparation method of the tissue adhesive comprises the following steps: step 1, preparing a polyphenol compound and recombinant mussel mucin into a solution, and uniformly stirring for later use, namely a solution A; 2, preparing a temperature response type high polymer material into a solution for later use, namely a solution B; and 3, mixing the solution A prepared in the step 1 and the solution B prepared in the step 2, fully and uniformly mixing, shaking and centrifuging, and discarding the supernatant. By selecting the temperature response type high polymer material, the tissue adhesive is endowed with the characteristic of temperature sensitivity, so that the modulus of the adhesive at the human body temperature is improved, and the colloid contraction can further promote wound closure. The mussel mucin is introduced to stimulate collagen regeneration of the wound part, activate the immune mechanism and remodel the wound microenvironment so as to achieve the purpose of promoting healing.

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

The invention discloses an intelligent bandage integrating wound monitoring, drug administration and electrical stimulation. The intelligent bandage comprises a bandage body, a portable battery, a wound monitoring module, an intelligent drug administration module, an electrical stimulation module and a portable control module. The bandage body is of a double-layer structure, the inner layer is an antibacterial fiber layer, and the outer layer is a breathable waterproof layer. By means of the design, the wound can be kept dry, and external bacteria can be prevented from invading. The bandage body is further provided with a bandage elastic area which is used for adjusting the tightness of the bandage so as to meet the requirements of different wound parts. 3-6 sensors are arranged on the inner surface of the bandage body and used for monitoring key physiological indexes of a wound in real time, and accurate information is provided for treatment. The intelligent drug delivery module adopts a drug-loaded stimuli-responsive electroactive hydrogel fiber array and is arranged on the inner surface of the bandage body, and accurate drug delivery is achieved through a voltage modulation electrode. The electrical stimulation module adopts a pseudo convergence electric field configuration, is arranged on the inner surface of the bandage body, and is switched between the electrical stimulation electrodes through a timing relay so as to alternately push the wound to be closed. The portable battery supplies power to the portable control module, and the portable control module comprises an integrated microprocessor module, a wireless communication module and a lumped power management module and is connected with the intelligent drug delivery module, the wound monitoring module and the electrical stimulation module to achieve remote monitoring and personalized treatment.

The device comprises a pre-stretching elastic film layer which is sequentially stacked, a gradient drainage layer is arranged below the pre-stretching elastic film layer, and sealing edges are arranged on the outer edges of the pre-stretching elastic film layer and the gradient drainage layer. The sealing edge surrounds the edges of the pre-stretching elastic film layer and the gradient drainage layer and is used for being bonded with the skin to form a closed cavity. Continuous negative pressure is provided through retraction force of the pre-stretched elastic thin film layer, compared with a traditional external pump, the cost is lower, use is more convenient, adhesion with a postoperative wound part is prevented through the arrangement of the anti-adhesion contact layer, and the postoperative wound part is prevented from being damaged. And meanwhile, the anti-adhesion contact layer is provided with a micron-sized bulge array and nano-sized surface textures, so that the anti-adhesion effect is further ensured, and the drainage efficiency is improved through the design of the gradient drainage layer.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. A novel platinum catalyst comprising platinum tetramethyldivinyl disiloxane diethyl maleate complex for use in such compositions provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The invention discloses a preparation method and application of a novel hybrid extracellular vesicle. According to the invention, vesicles derived from endothelial cells and neutrophil cells are combined with deferoxamine, and a biological mixed nano vesicle platform (DFO (HEVS)) is developed to solve the problem of diabetes wound healing. According to the dual-targeting system, DFO is accurately delivered to a wound part by utilizing CXCR4 mediated endothelial cell homing and beta2 integrin dependent inflammation tropism, DFO (at) HEVs activates and recovers vascular regeneration through HIF-1alpha / VEGF, ferroptosis is inhibited through Nrf2 / GPX4 signal transduction, macrophages are reprogrammed into a repair promoting M2 phenotype, and oxidative stress-inflammation-ferroptosis circulation is effectively broken.

The invention provides a life support stretcher. The life support stretcher is internally provided with a controller and an air bag pressurization binding belt used for binding the wounded, wherein a vital sign data detection unit is arranged in the air bag pressurization binding belt; the life promotion data specifically comprises heart rate, breathing parameters, blood pressure, body temperature and oxyhemoglobin saturation; the controller is used for controlling the air pressure in the air bag pressurization binding belt according to the vital sign data, detected by the vital sign data detection unit, of the wounded, and dynamically adjusting the binding tightness degree through a multi-modal data fusion algorithm and wound part recognition. Thus, when the life support stretcher is used for transferring a wounded person, the air bag pressurization binding belt can be used for binding the wounded person, the vital sign data of the wounded person can be detected through the vital sign data detection unit in the air bag pressurization binding belt, and then the controller can control the wounded person according to the detected vital sign data. And the air pressure in the air bag pressurizing binding belt is controlled, so that the trauma to the wounded caused by bumping is reduced.

The application discloses a light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme, a preparation method and application, and belongs to the technical field of biomedical materials. In the application, spherical silica nanoparticles are used as a template, and a structure of copper ion-polydopamine coated silica nanoparticles is formed on the surface of the silica nanoparticles through self-polymerization of dopamine and chelation of copper ions, and the spherical structure is maintained with the support of the silica nanoparticles. The copper ion-polydopamine coated silica nanoparticles are pyrolyzed to obtain a copper-based single-atom nanoscale enzyme with a carbon skeleton, and a hollow spherical single-atom nanoscale enzyme is obtained after etching. Nitric oxide donor molecules are loaded into the hollow of the hollow spherical single-atom nanoscale enzyme to obtain the light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme. The application can realize the synergistic treatment effect of photothermal therapy, nitric oxide gas therapy and biological catalytic therapy, is used for efficiently removing bacteria and biofilms at an infected wound site, and effectively promotes the healing of the bacteria-infected wound.

Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Disclosed herein are embodiments of a non-woven hybrid-scale fiber matrix sheet which can be used to improve wound healing. The non-woven hybrid-scale fiber matrix sheet may be both microporous, due to the hybrid-scale fiber matrix, as well as macroporous through the addition of cuts or perforations in the hybrid-scale fiber matrix sheet. The micro and macroporous sheet can improve biological healing at a wound site.

A system for irrigation and debridement of a wound site includes an irrigation vessel, the irrigation vessel having a at least one opening and containing an irrigant solution; and a deployment head configured to couple to the at least one opening, the deployment head is configured to facilitate egress of the irrigant solution from within the irrigation vessel; wherein the deployment head, comprises: a base, the base configured to couple to the at least one opening; a stem coupled to the base at a first end, the stem having an inner channel that is in fluid communication with the irrigation vessel and configured to allow flow of the irrigant solution therethrough; and an outlet coupled to the base at a second end, the outlet having at least one aperture disposed therein, wherein the at least one aperture is fluidly coupled to the inner channel, the at least one aperture configured to expel the irrigant solution from the vessel; wherein the outlet comprises a working surface configured to debride a wound site.

An osmotic bandage for treating wounds, such as cuts, abrasions, minor burns, blisters, and post-surgical incisions. The bandage includes a bandage strip with an adhesive along with a plurality of apertures or airholes disposed therethrough for breathability. The bandage further includes a multi-layered gauze pad. The multi-layered gauze pad includes a first layer, a second salt laced layer, and a third odor-reducing layer. The salt is a natural bactericide, through the dehydration of water in bacteria, and kills any bacteria that attempt to invade or enter the wound site. A semi-permeable membrane cover may be disposed in overlying relation to the pad to prevent the salt from being in direct contact with the wound tissue and causing the patient pain.

The invention provides an antibacterial composite hydrogel dressing loaded with a herba houttuyniae nano preparation as well as a preparation method and application of the antibacterial composite hydrogel dressing, and belongs to the technical field of medicines. According to the composite hydrogel dressing, methacrylamide hydrogel serves as a matrix, houttuynia cordata carbon dots are prepared through a hydrothermal synthesis method, the houttuynia cordata carbon dots and houttuynia cordata exosomes are jointly loaded in the methacrylamide hydrogel, and the composite hydrogel dressing is obtained. Wherein the herba houttuyniae carbon dots endow the hydrogel dressing with remarkable antibacterial activity and biocompatibility; ceramide, monogalactose diglyceride, phosphatidyl ethanolamine and the like in lipid components of the herba houttuyniae exosome have potential anti-inflammatory and tissue regeneration functions. The composite hydrogel loaded with the cordate houttuynia nano preparation prepared by the invention can realize controlled release of cordate houttuynia carbon dots and exosomes at wound parts, not only can promote cell proliferation and migration, but also can promote healing of diabetic wounds, and provides a new thought for healing of diabetic wounds.

The invention relates to a hydrogel light-operated multi-mode synergistic treatment platform based on a CuxS-MoS2 heterojunction for promoting wound healing of diabetes mellitus. And an interface induced electric field strategy is provided through density functional theory (DFT) calculation to optimize the charge migration behavior of the phototherapy agent. The multifunctional phototherapy system is constructed by taking CuxS-MoS2 with a built-in electric field as a core and PVA-CS hydrogel loaded with glucose oxidase (GOx) as a bracket. In a weakly acidic wound microenvironment, glucose at the wound is catalyzed by GOx to be converted into H2O2 and gluconic acid; meanwhile, the CuxS-MoS2 remarkably enhances the generation of reactive oxygen species (ROS) under illumination through peroxidase-like (POD) activity, photothermal effect (PTT) and heterojunction efficient carrier separation. After entering a proliferation period, the stent exerts catalase-like (CAT) activity to remove excessive ROS and release oxygen, and oxygen deficit and oxidative stress are relieved. In addition, the controllably released copper ions regulate and control the behavior of fibroblasts, promote healing and inhibit fibrosis. Experiments prove that the stent has excellent biocompatibility, effective antibacterial property and remarkable healing promoting effect in chronic wound repair of diabetes mellitus.

A system for wirelessly controlling a dressing interface that performs negative pressure wound therapy and fluid instillation therapy at a wound site. The system comprises a core module comprising: i) a plurality of sensors configured to determine a plurality of physical parameter data associated with the wound site; ii) a processor coupled to the plurality of sensors and configured to read the physical parameter data from the plurality of sensors; iii) a wireless transceiver coupled to the processor and configured to communicate with an external therapy controller; and iv) at least a first internal peripheral device coupled to the processor. The system further comprises at least a first external peripheral interface coupled to the core module and configured to communicate with the processor, wherein the core module and the at least a first external peripheral interface are disposed within a housing of the dressing interface.

A surgical dressing is disclosed. The surgical dressing may have a dressing element, a connection element, and a tube element. The dressing element may be applied to a wound site of an organic body. The dressing element and tube element may be coupled at opposing ends of the connection element. The tube element may be coupled to a tube extending from the wound site. A secondary layer may be coupled to the connection element to retain the connection element in a stretched condition. The secondary layer may be removed from the connection element to enable the connection element to stretch or retract in response to forces applied to or removed from the tube.

The invention relates to the field of biomedical materials, in particular to an Nb2C MXene composite functional film capable of promoting angiogenesis and a preparation method of the Nb2C MXene composite functional film, the Nb2C MXene composite functional film is particularly suitable for diabetes wound healing, and the Nb2C MXene composite functional film comprises an Nb2C MXene functionalized collagen vitrified film layer, and a carboxymethyl chitosan vitrification film layer, wherein a nano interlocking interface is formed between the Nb2C MXene functionalized collagen vitrified membrane layer and the carboxymethyl chitosan vitrified membrane layer; the Nb2C MXene functionalized collagen vitrified membrane layer is hydrophobic, the carboxymethyl chitosan vitrified membrane layer is hydrophilic, through the double-layer asymmetric structural design, the inner layer is tightly attached to a wound, the outer layer prevents adhesion of bacteria and tissues, and the barrier function in the wound healing process is effectively guaranteed; the adopted Nb2CMXene has excellent ROS (reactive oxygen species) removal capacity, oxidative stress of wound parts can be effectively relieved, cell damage is avoided, and cell functions are recovered.

The invention discloses double-network hydrogel based on chlorogenic acid as well as a preparation method and application of the double-network hydrogel, and belongs to the technical field of wound dressings. A first network of the double-network hydrogel based on the chlorogenic acid is formed by coordination of the chlorogenic acid and Zn < 2 + >, and CA and Zn < 2 + > can be quickly released in inflammation and proliferation stages, so that the effects of resisting bacteria, resisting oxidation, diminishing inflammation and generating blood vessels are achieved; the second network is formed by covalent crosslinking of heparin grafted gelatin and genipin, crosslinking of gelatin and genipin can enhance the mechanical strength, heparin is grafted into gelatin, bFGF can be stably added, the release time of bFGF at a wound part can be prolonged, and bFGF is slowly released in proliferation and remodeling stages, so that scars are prevented from being formed; in-vivo studies of MRSA infected diabetic mouse models and rabbit ear hyperplastic scar models show that the dual-network hydrogel can significantly promote healing of scar-free wounds. The programmed release function of the CZGF hydrogel plays a key role in accelerating chronic wound healing and preventing scar formation.

A biologic matrix comprises a three-dimensional, resorbable collagen scaffold derived from a vascularized portion of a perfusion-decellularized, suspension-dried mammalian organ or tissue. The scaffold features a porous structure with a plurality of interconnected pores originating from one or more of its outer surfaces. The pores are created by forcing a gas through the vascular pathways of the mammalian organ or tissue while it is in a suspended position. This enables the gas to inflate the vascular pathways in all directions without restriction. The porous configuration substantially enhances the scaffold's effective surface area, making it at least 10 times greater than that of a non-porous scaffold having equivalent outer dimensions. In certain embodiments, the surface area considering the interconnected pores can be 15 times larger or more than the non-porous scaffold of equivalent outer dimensions.

The invention discloses a degradable electrospinning dressing, and belongs to the technical field of biological materials.The degradable electrospinning dressing is prepared by dispersing aminosilane modified FeO in a chitosan solution, adding a gelatin solution, stirring and mixing evenly, conducting gradient freezing under the action of a rotating magnetic field, conducting permeation with a PLGA solution, then conducting electrospinning, conducting crosslinking with a genipin solution, conducting washing and conducting drying. And sterilizing to obtain the degradable electrospinning dressing. According to the degradable electrospinning dressing prepared by the preparation method disclosed by the invention, an electrospinning auxiliary material is obtained through three-layer gradient electrospinning by modifying a Fe3O4 enhanced chitosan-gelatin composite base material with amino silane and combining magnetic field assistance and gradient freezing forming, a bionic fiber structure is constructed, wound exudation dynamic balance and long-acting antibiosis are realized, the optimal moisture balance of a wound part is kept, and the antibacterial property of the wound part is improved. And wound healing is effectively promoted.

To provide a hydrocolloid tape for skin application that minimizes the possibility of the leakage of an exudate from perforations.SOLUTION: A hydrocolloid tape for skin application comprises: a tape-shaped film serving as a base material; a hydrocolloid material laminated on one side of the film; and a line of perforations provided in the film, where the perforations include alternating cut and non-cut portions, the cut portions penetrating through the film, the non-cut portions not penetrating through the film; where the individual length of each cut portion in the line of perforations is at least less than 2.0 mm.SELECTED DRAWING: Figure 4

Standard backing sheets on bandages are made to secure the placement of the absorption pad and to prevent blood from seeping out. With these standard bandages the blood will accumulate in a single area from the wound site. This buildup in a single area will cause more frequent bandage replacements and it can cause seepage issues. The buildup can also cause a more damp and wet feeling for the user.The improved medical bandage backing sheet can prevent this and distribute the blood from a wound site throughout that absorption pad. Utilizing the maximum surface area of that absorption pad or gauze and prevent blood build up in one certain area. In return causing less seepage, a damp feeling to the user, and bandage replacements. The improved backing sheet can also be made with oligodynamic coated threads giving it antimicrobial properties.

The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) formulated in a pullulan hydrogel. The release profile of the FAK inhibitor can be adjusted according to the nature of the wound, e.g., excisional wounds, burn wounds, etc.

This invention discloses a method for preparing a composite spray that improves hemostasis at wound sites. The composite spray includes solution A and solution B, where solution B is an aqueous solution of sodium alginate. The preparation method of solution A includes: 1. Dissolving a lipopeptide conjugate, cholesterol, distearylphosphatidylcholine, distearylphosphatidylserine, and dimethyl sulfoxide in a chloroform-methanol mixed solution to obtain a mixed system; 2. Preparing a precursor solution from the mixed system using a thin-film hydration method; 3. Adding calcium chloride to the precursor solution and reacting it in the dark to obtain solution A. This invention designs the precursor solution based on the function of natural platelets, and its function is equivalent to that of nanoplatelets. Combined with sodium alginate, it can specifically alleviate the adverse effects on the coagulation system caused by blood loss, such as fibrin degradation and reduced platelet activation, at wound sites. It has the characteristics of rapid hemostasis, good bioactivity, and rapid wound healing.

The utility model discloses an animal limb operation strapping device, which belongs to the technical field of strapping hemostasis and comprises a limb sheath. A plurality of ribbons which are arrayed in the circumferential direction and are not connected with one another are connected to the upper portion of the limb sheath, a threading hole is formed in the end of each ribbon, and all the ribbons can be fastened together by penetrating binding belts into the threading holes; dense anti-licking puncture parts are fixed on the side surface of each ribbon from inside to outside in a penetrating manner, and the dense anti-licking puncture parts are like thorns on a hedgehog body. The binding device is used for binding and stopping bleeding at amputation or amputated limb during animal operation, a bandage is bound at a wound firstly, then the limb sheath is sleeved on the outer side of the bandage, and due to the fact that the anti-licking puncture part on the side face of the bandage is like a thorn on a hedgehog, animals can be effectively prevented from licking or scratching the bandage at the wound, so that the bandage is prevented from falling off, and the wound is prevented from being infected.

The invention relates to the technical field of biological materials, and discloses a liquid dressing and a preparation method thereof, and the liquid dressing comprises a lipid phase and a water phase; the lipid phase comprises lecithin, glyceryl dioleate, polysorbate and an organic solvent; the water phase comprises hyaluronic acid or a salt thereof and a buffer solution, the molecular weight of the hyaluronic acid or the salt thereof is 500-5000Da, and the mass ratio of the hyaluronic acid or the salt thereof to lecithin is (0.05-0.2): 10. The mode of combining the lipid phase and the water phase is adopted, all components in the lipid phase and the water phase have a synergistic effect, free hyaluronic acid or salt thereof is released while the carrier transports hyaluronic acid or salt thereof, the free hyaluronic acid or salt thereof preferentially reaches an action target spot, and then the hyaluronic acid or salt thereof is slowly released under the carrier effect of the lipid phase, so that the hyaluronic acid or the salt thereof is slowly released. According to the present invention, the long-term and lasting protection on the wound part is achieved, the rapid release and slow release combined purpose is achieved, the in vivo immune system is enhanced, the overall cell inflammatory factor level in the body is significantly reduced, and the rapid and continuous pain relieving effect is achieved.

The present invention discloses a formulation of curcumin basedpowder spray that includes 95% Curcuma longa 2-6 %w / w, isopropyl myristate 01-0.2 %w / w, Aluminum Starch Octynyl Succinate 3-7 %w / w, n-pentane 18.7-22.7 %w / w and propellant 68-72 %w / w. Also disclosed is a process for preparation of the formulation of curcumin based antiseptic powder spray. This powder spray of the present invention is applied by spraying the same from an aluminum can directly on to a wound site to provide antiseptic protection without physically touching the wound. The powder spray is enhanced with the healing properties of turmeric (Curcuma longa), forming a protective layer on the wound site, effectively treating deep wounds, cuts, and abrasions from infections.

Apparatus and methods for a therapeutic boot that promotes the healing of pressures sores is described. Bedridden patients are prone to developing pressure sores over bony prominences of the foot such as a heel. The therapeutic boot includes a sides-down, open door design that provides unobstructed access to a wound site. The therapeutic boot may be designed to offload the patient's heel and bony prominences on both sides of the patient's ankle. The therapeutic boot is designed such that opening and closing the boot does not apply pressure and or friction to the wound site.