208 results about "Wound.exudate" patented technology

The invention discloses a preparation method and application of a multifunctional self-healing hydrogel material with antibacterial, anti-inflammatory and diabetic wound healing promotion functions. The preparation method comprises the following steps: firstly, synthesizing silver-doped carbon quantum dots (AgCD) in one step through a hydrothermal method; the preparation method comprises the following steps: firstly, preparing sodium hyaluronate (HA), secondly, oxidizing the sodium hyaluronate (HA) into oxidized hyaluronic acid (OHA) by taking sodium periodate as an oxidizing agent, and then encapsulating AgCD and metformin (Met) into hydrogel formed by Schiff base reaction between carboxymethyl chitosan (CMCS) and the oxidized hyaluronic acid (OHA). The hydrogel provided by the invention has certain adhesion, suitable capacity of absorbing wound exudate and good biocompatibility, meanwhile, due to the addition of AgCD, the hydrogel has excellent antibacterial property, and the metformin can promote angiogenesis of a wound part, so that the hydrogel can better promote healing of a diabetic wound. The hydrogel is simple and rapid in preparation method, has low biotoxicity and antibacterial property, and provides a strategic choice for promoting healing of diabetic wounds.

The invention provides an anorectal surgery postoperative care rehabilitation evaluation method and system. Wherein a vibration sensor is constructed through a machine tool machining vibration monitoring technology, vibration frequency offset of the dressing after absorbing wound seepage is detected in real time, and the vibration frequency offset is associated with dressing weight variation; meanwhile, an optical scattering measurement technology is adopted for carrying out scattering spectrum analysis on wound exudate, and the protein concentration index is analyzed. And carrying out time sequence correlation on the weight change data corresponding to the vibration frequency offset and the protein concentration index to generate a seepage component dynamic change curve. And through a wireless transmission unit in the remote measurement system, performing remote synchronous comparison on the dynamic change curve and a preset healing stage reference curve, and when the vibration frequency offset exceeding the standard seepage amount continuously appears in the curve and the protein concentration index breaks through the threshold range, triggering a remote early warning signal of wound healing abnormity. According to the technical scheme provided by the invention, the nursing rehabilitation efficiency and precision are improved.

The invention discloses a tube drawing prevention device capable of preventing wound seepage from flowing out, and relates to the technical field of medical instruments. The device comprises a bottom plate, a mounting structure is fixedly connected to the middle of the upper end face of the bottom plate, adjusting structures are symmetrically and fixedly connected to the lower end face of the bottom plate, fixing structures are symmetrically and slidably connected between the two adjusting structures, an anti-pulling structure is fixedly connected to the upper end face of the mounting structure, and a one-way flow blocking structure is arranged in the middle of an inner cavity of the mounting structure. A locking structure is fixedly connected to the left end face of the stabilizing structure on the left side, a lifting structure is arranged in the middle of an inner cavity of the locking structure, the distance between the two sliding blocks stretches out and draws back along a sliding rod by oppositely pulling the fixing frames, and therefore the distance between the fixing frames is adjusted by adjusting stretching out and drawing back of a spring; the drainage tube on the outer surface of the lower inserting tube is extruded and fixed, the stability of connection between the drainage tube and the lower inserting tube is ensured, and the drainage tube is prevented from loosening or falling off in the using process, especially under the condition that the body of a patient may move.

The invention belongs to the technical field of medical products, and provides a hydrogel dressing for diabetic chronic wounds and a preparation method and application of the hydrogel dressing. The antibacterial effect of the hydrogel dressing for the chronic wound surface of diabetes mellitus is improved by increasing the ZIF-8 coated AgNPs; in the hydrogel matrix part, the pH response is dominated by adjusting the component proportion of the temperature-sensitive agent N-isopropylacrylamide and the pH response 1-vinyl imidazole; the N-isopropylacrylamide assists the extension of a macromolecular chain segment in the composite hydrogel dressing, so that the dressing can fully absorb wound exudate and is easy to peel off, and secondary damage can be avoided.

The present invention relates to the technical field of diabetes, and in particular to a controlled-release diabetic wound healing promoting treatment method, comprising the following treatment experimental steps: step S1: preparation of Hst1@PNPs; step S2: Coomassie brilliant blue staining; step S3: scanning and transmission electron microscopy detection; in the present invention, a slow-release Hst1 treatment method is constructed by encapsulating Hst1 into platelet membrane vesicles derived from autologous blood. On the one hand, the PNPs encapsulate the linear Hst1 peptide structure to prevent it from being rapidly degraded by high proteases in diabetic wound exudate, thereby improving bioavailability. On the other hand, the PNPs can adsorb excess LPS in the wound exudate, and cooperate with Hst1 to achieve anti-inflammatory and anti-oxidative stress effects. Subsequent cell and animal experiments further confirmed that Hst1@PNPs have the effects of anti-inflammatory, scavenging ROS, promoting re-epithelialization, collagen deposition and angiogenesis, thereby promoting diabetic wound healing.

The invention discloses a negative pressure drug delivery dynamic adjusting device for a wound surface and a using method thereof, and relates to the technical field of medical instruments and equipment.The negative pressure drug delivery dynamic adjusting device comprises a machine shell, a control module, a connecting module, a negative pressure module and a drug delivery module in the wound surface are installed in the machine shell, a collecting chamber is arranged on one side of the bottom of the machine shell, and a pressure stabilizing linkage control mechanism is further arranged in the machine shell; the pressure stabilization linkage control mechanism is used for dynamic regulation and control of negative pressure and drug administration in the wound surface; the connecting module is used for uniform negative pressure of the wound surface and drug administration in the wound surface; according to the scheme, multi-mode free combination is adopted, single negative pressure / in-wound drug delivery, synchronous linkage, reverse linkage and an alternating mode are supported, the full-period requirement from acute trauma to chronic repair is met, and intelligent parameter matching is conducted, for example, through pressure-flow closed-loop feedback, when the negative pressure value rises, the drug delivery flow speed in the wound is automatically reduced, and when the negative pressure value rises, the drug delivery flow speed in the wound is automatically reduced; when wound exudate is reduced, pulse negative pressure is triggered to promote microcirculation.

The invention provides a wound exudate amount type determination method. The method comprises the following steps: acquiring wound humidity data at a plurality of moments; performing curve fitting on the wound surface humidity data based on a first-order system model, and determining a system gain and a time constant of the first-order system model; based on the system gain and the time constant, a corresponding wound surface seepage amount type is determined through a pre-established dichotomy model, and the dichotomy model is established based on pre-provided wound case data. In addition, the invention further relates to a wound surface seepage amount type determining device applying the wound surface seepage amount type determining method, and further relates to a wound surface humidity monitoring device and a wound surface humidity monitoring system comprising the wound surface seepage amount type determining device.

An adhesive bandage having a backing material and a hydrocolloid pad disposed thereon effectively removes wound exudate while enabling facile removal. The bandage includes a backing material comprising a sheet having an adhesive layer disposed thereon having a first color. The hydrocolloid pad has an absorbency (24 hr) of between about 2 and about 6 g / g, and includes a hydrocolloid layer forming a first surface thereof and a polymeric film layer having a second color associated therewith different than the first color of the backing material forming a second surface thereof. The hydrocolloid pad is disposed in facing relation and adhered to the adhesive layer of backing material. The first surface having a dry peel strength of between about 0 and about 700 gf, a wet peel strength of between about 0 and 150 gf.

The invention provides a preparation method and application of tannic acid and panax notoginseng total saponins composite drug-loaded multifunctional hydrogel, and relates to the technical field of biomedical materials.Chitosan, one of the components of the hydrogel, is subjected to carboxymethylation modification to form carboxymethyl chitosan, the carboxymethyl chitosan and aldehyde-modified xanthan gum are subjected to a Schiff base reaction, and the hydrogel is prepared into the multifunctional drug-loaded tannic acid and panax notoginseng total saponins composite drug-loaded multifunctional hydrogel. Meanwhile, tannic acid and panax notoginseng saponins are loaded, and the composite hydrogel is obtained. The hydrogel loaded with the tannic acid and the panax notoginseng saponins, provided by the invention, carries the tannic acid and the panax notoginseng saponins as active substances, can keep the activity of the medicine for a long time, and has good injectability, self-healing property and wound exudate absorption property, the tannic acid can inhibit inflammatory response and reduce the generation and release of inflammatory factors, and the hydrogel loaded with the tannic acid and the panax notoginseng saponins can be used for treating wound exudate. The tannic acid has a wide antibacterial property, such as IL-1beta, IL-6, TNF-alpha and the like, and can inhibit the growth and reproduction of various bacteria, including common pathogenic bacteria such as staphylococcus aureus, escherichia coli and the like.

Disclosed herein are devices, wound dressings and methods for determining the pH of fluid or a wound exudate at a wound. Example devices include a device comprising a surface configured to contact the fluid or wound and a pH indicator covalently bound thereto or applied to the surface, wherein the pH indicator has a first colour prior to contact with the fluid or the wound exudate and changes colour as a function of the pH of the fluid or wound exudate. Example devices include a device which indicates wound exudate loading within a wound dressing and wound dressing comprising an absorbent layer and a moisture indicator which indicates would exudate loading within the dressing, wherein the visibility of the moisture indictor changes as a result of a physical transformation of a first material within the dressing. Systems, devices, and methods are provided for monitoring wound status and progression by measuring pH levels indicated by pH-sensitive wound dressings. In some implementations, a wound is monitored by capturing an image of the pH-sensitive wound dressing and processing the captured image to determine the color of a pH indicator included on the wound dressing. The color of the indicator is determined in terms of RGB values from the image, and a pH value for the wound dressing is calculated from the dressing RGB values. The calculated pH value is then relayed to a user to be used as an indicator of wound status or health.

The invention discloses an intelligent adhesive bandage and a preparation method thereof, a textile and a wearable device. The intelligent adhesive bandage comprises a super-hydrophilic thin film, an electrochemical sensor and a hydrophobic thin film, the electrochemical sensor is connected to the super-hydrophilic thin film, and the hydrophobic thin film and the super-hydrophilic thin film are connected in a stacked mode to achieve packaging of the electrochemical sensor. By constructing the super-hydrophilic thin film and the hydrophobic thin film and integrating the electrochemical sensor between the two layers of thin films, the prepared intelligent adhesive bandage has wound exudate one-way conduction and dynamic detection capabilities, and a low-cost, rapid and convenient intelligent adhesive bandage processing scheme is realized; the method is expected to assist in wound cleaning and drying, wound environment dynamic monitoring and wound infection condition prompting.

An adhesive bandage having a backing material and a hydrocolloid pad disposed thereon effectively removes wound exudate while enabling facile removal. The bandage includes a backing material comprising a sheet having an adhesive layer disposed thereon having a first color. The hydrocolloid pad has an absorbency (24 hr) of between about 2 and about 6 g / g, and includes a hydrocolloid layer forming a first surface thereof and a polymeric film layer having a second color associated therewith different than the first color of the backing material forming a second surface thereof. The hydrocolloid pad is disposed in facing relation and adhered to the adhesive layer of backing material. The first surface having a dry peel strength of between about 0 and about 650 gf / inch (255 gf / cm), a wet peel strength of between about 0 and 200 gf / inch (80 gf / cm).

The invention discloses a preparation method of a fibroin / collagen composite sponge for chronic wound repair, which comprises the following steps: S1, freeze-drying a silk fibroin solution with the mass concentration of 0.02-0.07 g / mL to obtain a silk fibroin sponge; s2, immersing the silk fibroin sponge into an alcohol solution for incubation, and then washing and drying to obtain insoluble silk fibroin sponge; and S3, immersing the insoluble silk fibroin sponge into a collagen solution with the mass concentration of 0.001-0.006 g / mL and the pH value of 5.0-5.5, so that after the insoluble silk fibroin sponge absorbs the collagen solution, freeze-drying to prepare the fibroin / collagen composite sponge. The fibroin / collagen composite sponge prepared by the method has excellent water binding capacity, moisture permeability and water retention capacity, can effectively remove wound exudate, adjust and maintain a wet healing environment, also can actively induce tissue regeneration and promote wound healing, and can meet the use requirements of chronic wounds on ideal wound dressing materials.

The invention relates to a dressing (16) for use in the negative pressure therapy of wounds, having: a wound contact layer (28); an air-impermeable top layer (34), wherein a receiving space (36) is formed between the top layer and the wound contact layer, wherein the wound contact layer is designed such that it is liquid-permeable and draws wound exudate from the wound into the receiving space, and wherein a connection opening (26) is formed in the top layer; and at least one distribution layer (50) arranged in the receiving space, wherein the distribution layer extends in two surface directions (X, Y) and is designed to distribute wound exudate in the surface directions. According to the invention, the distribution layer is formed by a flat material web portion (52), a first side (56) of the flat material web portion is designed as a structure defined by elevations (60) that are formed integrally with a plane (54) of the flat material web portion, a terminal through-opening (64) is formed in at least some of the elevations, and a cohesive intermediate space (66) is formed between the elevations.

The utility model discloses a wound seepage amount metering assembly, and relates to the field of medical instruments. Provided is a wound exudate amount measuring assembly capable of measuring wound exudate more easily. The wound seepage amount metering assembly comprises a dressing clamp and a portable scale with a hook; the dressing clamp comprises a first clamping rod, a second clamping rod, a hinge shaft, an elastic piece, a hanging ring, two connecting sleeves, two clamping pieces and two jacking screws. The first clamping rod and the second clamping rod are hinged through a hinge shaft; the two connecting sleeves are respectively connected with the front end of the first clamping rod and the front end of the second clamping rod; each clamping piece comprises a clamping piece body and a clamping piece rod; the clamping piece rods of the two clamping pieces are respectively inserted into the two connecting sleeves and are in clearance fit with the connecting sleeves; the two puller screws are in threaded connection with the two connecting sleeves respectively and abut against the clamping piece rods of the two clamping pieces respectively. The elastic force of the elastic piece enables the front ends of the two clamping pieces to be tightly attached. The hanging ring is connected with the rear end of the first clamping rod; the hook is used for hooking the hanging ring.

The present application relates to an evaluation system for medical dressings, comprising a suction unit, a collection unit, a detection unit and a processing unit, the suction unit, which is in communication with a medical dressing covering a wound of a patient, is capable of transmitting negative pressure to the medical dressing and pumping wound exudate out of the medical dressing in the form of a fluid, the processing unit, based on detection results obtained by one or more detection components in the detection unit, adjusts a preset time period for the activation of the collection unit, wherein the activation of the collection unit is at least automatically controlled based on the preset time period and / or manually controlled based on a switch of a treatment program. The evaluation system is used to determine the actual use of a medical dressing in a treatment work for different categories of wounds, so as to obtain the expected use of any medical dressing in a treatment work for a specified category of wounds.

The invention belongs to the field of medical dressings and skin care, and particularly relates to a live calcium wet dressing film material as well as a preparation method and application thereof. The live calcium wet dressing film material comprises a substrate film material and a replacement activation solution, wherein the basement membrane is made of calcium alginate fiber blended fabric; the replacement activation liquid comprises the following raw materials in percentage by mass: 1-4% of sodium gluconate, 0.1-3% of sodium chloride, 0.01-2% of dipotassium glycyrrhizinate, 0.1-5% of polysaccharide and the balance of water. Sodium ions and potassium ions in the replacement activation liquid are exchanged with calcium ions in the basement membrane material, active calcium ions can be actively and rapidly released without depending on wound exudate, anti-inflammatory moisturizing components are synergistically delivered, and meanwhile protective hydrogel is formed in situ, so that the beneficial effects of rapid relieving and multiple repairing are achieved.

The present invention discloses an anti-inflammatory and healing-promoting electrospun wound dressing, a preparation method and an application thereof, belonging to the technical field of medical dressings, and comprising a double-layer structure of an inner layer and an outer layer; wherein, the outer layer is a hydrophilic nanofiber membrane prepared by single-nozzle electrospinning, and is used to absorb wound exudate; the inner layer is a nanofiber membrane with a core-shell structure prepared by coaxial electrospinning, and the shell layer of the core-shell structure is a hydrophobic material, and is used to guide the exudate to the outer layer; the core layer of the core-shell structure comprises hydrophilic thermosensitive macromolecules, healing-promoting growth factors and anti-inflammatory drugs; the shell layer is hydrophobic, and guides the wound exudate to the outer hydrophilic nanofiber membrane; the gelatin hydrophilic thermosensitive macromolecules in the core layer, when the wound inflammation causes the local temperature to be ≥37°C, the temperature change causes the drug-loaded thermosensitive phase change macromolecules to undergo different degrees of phase change, thereby achieving timely and controllable release of drugs and ensuring the healing of the wound surface.

A system, method, and apparatus are disclosed for dressing a wound. The apparatus comprises a liquid and gas permeable transmission layer, an absorbent layer for absorbing wound exudate, the absorbent layer overlying the transmission layer, a gas impermeable cover layer overlying the absorbent layer and comprising a first orifice, wherein the cover layer is moisture vapor permeable.

The invention discloses a preparation method of metal zinc-curcumin complex doped alginate-based antibacterial hydrogel, which comprises the following steps: preparing a metal zinc-curcumin complex by utilizing the coordination effect between metal zinc ions and curcumin molecules, and then mixing and reacting the metal zinc-curcumin complex with a hydroxyapatite nano material to prepare a composite nano material. And preparing a dispersion liquid from the obtained composite nano material, adding polyvinyl alcohol and sodium alginate, stirring and mixing, and adding CaCl2 for crosslinking, thereby obtaining the alginate-based antibacterial hydrogel. The metal zinc-curcumin complex is doped, so that the obtained hydrogel has good antibacterial performance, and the obtained hydrogel has a communicated macroporous structure, so that the absorption capacity of the material to wound exudate can be remarkably improved, a necessary space channel can be provided for migration and adhesion of fibroblasts, and the wound exudate can be effectively absorbed. The method is crucial for maintaining long-term stability of a chronic wound environment and promoting wound healing, so that the method has a good application prospect.

A wound cleaning device comprises a carrier layer and a wound cleaning layer arranged on the carrier layer for absorbing wound exudate and / or solid wound components and having a cleaning thread, wherein the carrier layer and / or the wound cleaning layer are provided with at least one storage substance that improves the absorption capacity of wound exudate.

1. Name of the design product: Negative pressure dressing device. 2. Use of the design product: A medical device for treating wounds by negative pressure drainage of wound exudate. 3. Design key points of the design product: Lies in the shape. 4. Picture or photograph that best shows the design key points: Perspective view 1.

The invention relates to the technical field of dressings, in particular to a recombinant collagen wound dressing and a preparation method thereof. The dressing is of a film-like structure and is prepared from the following raw materials: a selective methacrylated recombinant collagen concentrated solution, oxidized sodium hyaluronate and carboxymethyl chitosan. A collagen permanent cross-linked network is formed through visible light curing, and a multi-layer stable network is constructed by combining cross-linking between oxidized sodium hyaluronate and carboxymethyl chitosan and ion micro-cross-linking initiated by calcium ions. According to the preparation method, the methylacryloylation degree is accurately controlled, and the component adding time sequence (especially surface atomization and infiltration of carboxymethyl chitosan) is optimized, so that the good processability of a precursor is ensured; and the final product can still maintain excellent wet mechanical properties, form stability, liquid management capability and mild dressing change compliance after absorbing wound exudate.

The application provides a preparation method and application of a high-efficiency emergency antibacterial dressing and belongs to the technical field of biomedical materials. The high-efficiency emergency antibacterial dressing is prepared through a systematic process of alcohol-free wet spinning, secondary traction stretching, vacuum freeze drying, semi-dry state rapid carboxymethylation and needle punching / water jetting into cloth. The high-efficiency emergency antibacterial dressing has high mechanical strength and strong liquid absorption capacity, can absorb a large amount of wound exudate and keep the wound moist, and realizes the synergistic effect of multiple functions such as emergency, anti-adhesion, strong stability, antibiosis and repair promotion.

A wound dressing according to certain embodiments includes an adhesive layer for adhering the wound dressing adjacent to a wound, a wound contact layer for contacting the wound, a backing layer comprising a port, a tube having a first end connected with the port and an opposite second end, a first fitting connected to the second end of the tube, the first fitting configured for connection with a second fitting of the negative pressure wound therapy system to apply a negative pressure via the port, and a filter disposed within the first fitting. In certain embodiments, the filter is formed of polyethersulfone (PESU) and has an average pore size of at least 2 microns.

A method for preparing a sponge based on collagen-like proteins starts with providing an aqueous solution having at least one collagen-like protein. A cross-linker reacts with the collagen-like protein to obtain a hydrogel and lyophilization leads to the sponge. The sponge obtained by the method shows increased performance in wound sealing, haemostasis, wound plugging, healing promotion, bone regeneration, cartilage repair, cell cultures, production of vegetarian or vegan meat or the absorption of biological fluids, like blood or wound exudate.

The application relates to the field of foam dressings, in particular to a wet medical polyurethane foam dressing and a preparation process thereof. The raw material scheme of the wet medical polyurethane foam dressing comprises polyurethane prepolymer, deionized water, a hydrophilic auxiliary agent, a chain extender, a gel catalyst, a foaming catalyst and a reinforcing agent and the like. The wet medical polyurethane foam dressing provided by the application has excellent comprehensive use performance. After absorbing a large amount of wound exudate, the dressing can still firmly lock the liquid under pressure, significantly inhibits the reverse osmosis phenomenon, and avoids the immersion damage of the skin around the wound. Meanwhile, the dressing has good flexibility and wet structure integrity, can be used in conformity with the wound contour, is not easy to adhere to the new tissue when being replaced, the stable long-acting liquid absorption capacity helps to prolong the replacement period, reduces the nursing workload and medical cost, and provides a more reliable and efficient solution for exudative wound management.

This application belongs to the technical field of medical dressings, and particularly relates to a microcurrent sponge dressing for promoting pressure ulcer healing and its application. It includes a diaphragm, a cathode sponge, and an anode sponge; the cathode sponge is annularly wrapped outside the diaphragm; the anode sponge is cylindrically distributed inside the diaphragm. In the microcurrent sponge dressing provided by the present invention, the cathode sponge and the anode sponge generate a redox reaction in the wound exudate to produce an electric current; this microcurrent can promote collagen regeneration, and at the same time can generate zinc metal ions with antibacterial effects, which can reduce the risk of wound infection and promote wound healing; in addition, the microcurrent sponge dressing has a three-dimensional porous structure, has excellent water absorption performance, can fully absorb wound exudate, and also has good elasticity, and can provide a buffer layer between the patient and the support surface to reduce the wound surface pressure, ultimately promoting the healing of the pressure ulcer wound surface.

The utility model relates to a wound dressing which comprises a base material layer, a liquid absorption layer and a diffusion layer which are sequentially stacked, the diffusivity of wound exudate on the diffusion layer is larger than that of the wound exudate on the liquid absorption layer, and the diffusion layer is used for diffusing the wound exudate and then conducting the wound exudate to the liquid absorption layer. After the wound exudate is in contact with the diffusion layer, the wound exudate diffuses in the diffusion layer and then is conducted to the imbibition layer after diffusion, and the diffusivity of the wound exudate in the diffusion layer is larger than that of the wound exudate in the imbibition layer, so that the diffusion area of the wound exudate in the diffusion layer is larger than that of the wound exudate in the imbibition layer; therefore, the wound exudate is diffused through the diffusion layer and then conducted to the exudate absorption layer, the absorption area of the exudate absorption layer is larger, the peripheral area of the exudate absorption layer can also absorb the wound exudate, the utilization rate of the exudate absorption layer is higher, and the exudate absorption capacity of the exudate absorption layer can be fully utilized.