138 results about "Wound.exudate" patented technology

The invention belongs to the technical field of medical products, and provides a hydrogel dressing for diabetic chronic wounds and a preparation method and application of the hydrogel dressing. The antibacterial effect of the hydrogel dressing for the chronic wound surface of diabetes mellitus is improved by increasing the ZIF-8 coated AgNPs; in the hydrogel matrix part, the pH response is dominated by adjusting the component proportion of the temperature-sensitive agent N-isopropylacrylamide and the pH response 1-vinyl imidazole; the N-isopropylacrylamide assists the extension of a macromolecular chain segment in the composite hydrogel dressing, so that the dressing can fully absorb wound exudate and is easy to peel off, and secondary damage can be avoided.

The invention discloses a negative pressure drug delivery dynamic adjusting device for a wound surface and a using method thereof, and relates to the technical field of medical instruments and equipment.The negative pressure drug delivery dynamic adjusting device comprises a machine shell, a control module, a connecting module, a negative pressure module and a drug delivery module in the wound surface are installed in the machine shell, a collecting chamber is arranged on one side of the bottom of the machine shell, and a pressure stabilizing linkage control mechanism is further arranged in the machine shell; the pressure stabilization linkage control mechanism is used for dynamic regulation and control of negative pressure and drug administration in the wound surface; the connecting module is used for uniform negative pressure of the wound surface and drug administration in the wound surface; according to the scheme, multi-mode free combination is adopted, single negative pressure / in-wound drug delivery, synchronous linkage, reverse linkage and an alternating mode are supported, the full-period requirement from acute trauma to chronic repair is met, and intelligent parameter matching is conducted, for example, through pressure-flow closed-loop feedback, when the negative pressure value rises, the drug delivery flow speed in the wound is automatically reduced, and when the negative pressure value rises, the drug delivery flow speed in the wound is automatically reduced; when wound exudate is reduced, pulse negative pressure is triggered to promote microcirculation.

The invention provides a wound exudate amount type determination method. The method comprises the following steps: acquiring wound humidity data at a plurality of moments; performing curve fitting on the wound surface humidity data based on a first-order system model, and determining a system gain and a time constant of the first-order system model; based on the system gain and the time constant, a corresponding wound surface seepage amount type is determined through a pre-established dichotomy model, and the dichotomy model is established based on pre-provided wound case data. In addition, the invention further relates to a wound surface seepage amount type determining device applying the wound surface seepage amount type determining method, and further relates to a wound surface humidity monitoring device and a wound surface humidity monitoring system comprising the wound surface seepage amount type determining device.

Disclosed herein are devices, wound dressings and methods for determining the pH of fluid or a wound exudate at a wound. Example devices include a device comprising a surface configured to contact the fluid or wound and a pH indicator covalently bound thereto or applied to the surface, wherein the pH indicator has a first colour prior to contact with the fluid or the wound exudate and changes colour as a function of the pH of the fluid or wound exudate. Example devices include a device which indicates wound exudate loading within a wound dressing and wound dressing comprising an absorbent layer and a moisture indicator which indicates would exudate loading within the dressing, wherein the visibility of the moisture indictor changes as a result of a physical transformation of a first material within the dressing. Systems, devices, and methods are provided for monitoring wound status and progression by measuring pH levels indicated by pH-sensitive wound dressings. In some implementations, a wound is monitored by capturing an image of the pH-sensitive wound dressing and processing the captured image to determine the color of a pH indicator included on the wound dressing. The color of the indicator is determined in terms of RGB values from the image, and a pH value for the wound dressing is calculated from the dressing RGB values. The calculated pH value is then relayed to a user to be used as an indicator of wound status or health.

The invention discloses a preparation method of a fibroin / collagen composite sponge for chronic wound repair, which comprises the following steps: S1, freeze-drying a silk fibroin solution with the mass concentration of 0.02-0.07 g / mL to obtain a silk fibroin sponge; s2, immersing the silk fibroin sponge into an alcohol solution for incubation, and then washing and drying to obtain insoluble silk fibroin sponge; and S3, immersing the insoluble silk fibroin sponge into a collagen solution with the mass concentration of 0.001-0.006 g / mL and the pH value of 5.0-5.5, so that after the insoluble silk fibroin sponge absorbs the collagen solution, freeze-drying to prepare the fibroin / collagen composite sponge. The fibroin / collagen composite sponge prepared by the method has excellent water binding capacity, moisture permeability and water retention capacity, can effectively remove wound exudate, adjust and maintain a wet healing environment, also can actively induce tissue regeneration and promote wound healing, and can meet the use requirements of chronic wounds on ideal wound dressing materials.

The invention relates to a dressing (16) for use in the negative pressure therapy of wounds, having: a wound contact layer (28); an air-impermeable top layer (34), wherein a receiving space (36) is formed between the top layer and the wound contact layer, wherein the wound contact layer is designed such that it is liquid-permeable and draws wound exudate from the wound into the receiving space, and wherein a connection opening (26) is formed in the top layer; and at least one distribution layer (50) arranged in the receiving space, wherein the distribution layer extends in two surface directions (X, Y) and is designed to distribute wound exudate in the surface directions. According to the invention, the distribution layer is formed by a flat material web portion (52), a first side (56) of the flat material web portion is designed as a structure defined by elevations (60) that are formed integrally with a plane (54) of the flat material web portion, a terminal through-opening (64) is formed in at least some of the elevations, and a cohesive intermediate space (66) is formed between the elevations.

The utility model discloses a wound seepage amount metering assembly, and relates to the field of medical instruments. Provided is a wound exudate amount measuring assembly capable of measuring wound exudate more easily. The wound seepage amount metering assembly comprises a dressing clamp and a portable scale with a hook; the dressing clamp comprises a first clamping rod, a second clamping rod, a hinge shaft, an elastic piece, a hanging ring, two connecting sleeves, two clamping pieces and two jacking screws. The first clamping rod and the second clamping rod are hinged through a hinge shaft; the two connecting sleeves are respectively connected with the front end of the first clamping rod and the front end of the second clamping rod; each clamping piece comprises a clamping piece body and a clamping piece rod; the clamping piece rods of the two clamping pieces are respectively inserted into the two connecting sleeves and are in clearance fit with the connecting sleeves; the two puller screws are in threaded connection with the two connecting sleeves respectively and abut against the clamping piece rods of the two clamping pieces respectively. The elastic force of the elastic piece enables the front ends of the two clamping pieces to be tightly attached. The hanging ring is connected with the rear end of the first clamping rod; the hook is used for hooking the hanging ring.

The present application relates to an evaluation system for medical dressings, comprising a suction unit, a collection unit, a detection unit and a processing unit, the suction unit, which is in communication with a medical dressing covering a wound of a patient, is capable of transmitting negative pressure to the medical dressing and pumping wound exudate out of the medical dressing in the form of a fluid, the processing unit, based on detection results obtained by one or more detection components in the detection unit, adjusts a preset time period for the activation of the collection unit, wherein the activation of the collection unit is at least automatically controlled based on the preset time period and / or manually controlled based on a switch of a treatment program. The evaluation system is used to determine the actual use of a medical dressing in a treatment work for different categories of wounds, so as to obtain the expected use of any medical dressing in a treatment work for a specified category of wounds.

The invention belongs to the field of medical dressings and skin care, and particularly relates to a live calcium wet dressing film material as well as a preparation method and application thereof. The live calcium wet dressing film material comprises a substrate film material and a replacement activation solution, wherein the basement membrane is made of calcium alginate fiber blended fabric; the replacement activation liquid comprises the following raw materials in percentage by mass: 1-4% of sodium gluconate, 0.1-3% of sodium chloride, 0.01-2% of dipotassium glycyrrhizinate, 0.1-5% of polysaccharide and the balance of water. Sodium ions and potassium ions in the replacement activation liquid are exchanged with calcium ions in the basement membrane material, active calcium ions can be actively and rapidly released without depending on wound exudate, anti-inflammatory moisturizing components are synergistically delivered, and meanwhile protective hydrogel is formed in situ, so that the beneficial effects of rapid relieving and multiple repairing are achieved.

The present invention discloses an anti-inflammatory and healing-promoting electrospun wound dressing, a preparation method and an application thereof, belonging to the technical field of medical dressings, and comprising a double-layer structure of an inner layer and an outer layer; wherein, the outer layer is a hydrophilic nanofiber membrane prepared by single-nozzle electrospinning, and is used to absorb wound exudate; the inner layer is a nanofiber membrane with a core-shell structure prepared by coaxial electrospinning, and the shell layer of the core-shell structure is a hydrophobic material, and is used to guide the exudate to the outer layer; the core layer of the core-shell structure comprises hydrophilic thermosensitive macromolecules, healing-promoting growth factors and anti-inflammatory drugs; the shell layer is hydrophobic, and guides the wound exudate to the outer hydrophilic nanofiber membrane; the gelatin hydrophilic thermosensitive macromolecules in the core layer, when the wound inflammation causes the local temperature to be ≥37°C, the temperature change causes the drug-loaded thermosensitive phase change macromolecules to undergo different degrees of phase change, thereby achieving timely and controllable release of drugs and ensuring the healing of the wound surface.

A system, method, and apparatus are disclosed for dressing a wound. The apparatus comprises a liquid and gas permeable transmission layer, an absorbent layer for absorbing wound exudate, the absorbent layer overlying the transmission layer, a gas impermeable cover layer overlying the absorbent layer and comprising a first orifice, wherein the cover layer is moisture vapor permeable.

The invention discloses a preparation method of metal zinc-curcumin complex doped alginate-based antibacterial hydrogel, which comprises the following steps: preparing a metal zinc-curcumin complex by utilizing the coordination effect between metal zinc ions and curcumin molecules, and then mixing and reacting the metal zinc-curcumin complex with a hydroxyapatite nano material to prepare a composite nano material. And preparing a dispersion liquid from the obtained composite nano material, adding polyvinyl alcohol and sodium alginate, stirring and mixing, and adding CaCl2 for crosslinking, thereby obtaining the alginate-based antibacterial hydrogel. The metal zinc-curcumin complex is doped, so that the obtained hydrogel has good antibacterial performance, and the obtained hydrogel has a communicated macroporous structure, so that the absorption capacity of the material to wound exudate can be remarkably improved, a necessary space channel can be provided for migration and adhesion of fibroblasts, and the wound exudate can be effectively absorbed. The method is crucial for maintaining long-term stability of a chronic wound environment and promoting wound healing, so that the method has a good application prospect.

The invention relates to the technical field of dressings, in particular to a recombinant collagen wound dressing and a preparation method thereof. The dressing is of a film-like structure and is prepared from the following raw materials: a selective methacrylated recombinant collagen concentrated solution, oxidized sodium hyaluronate and carboxymethyl chitosan. A collagen permanent cross-linked network is formed through visible light curing, and a multi-layer stable network is constructed by combining cross-linking between oxidized sodium hyaluronate and carboxymethyl chitosan and ion micro-cross-linking initiated by calcium ions. According to the preparation method, the methylacryloylation degree is accurately controlled, and the component adding time sequence (especially surface atomization and infiltration of carboxymethyl chitosan) is optimized, so that the good processability of a precursor is ensured; and the final product can still maintain excellent wet mechanical properties, form stability, liquid management capability and mild dressing change compliance after absorbing wound exudate.

The application provides a preparation method and application of a high-efficiency emergency antibacterial dressing and belongs to the technical field of biomedical materials. The high-efficiency emergency antibacterial dressing is prepared through a systematic process of alcohol-free wet spinning, secondary traction stretching, vacuum freeze drying, semi-dry state rapid carboxymethylation and needle punching / water jetting into cloth. The high-efficiency emergency antibacterial dressing has high mechanical strength and strong liquid absorption capacity, can absorb a large amount of wound exudate and keep the wound moist, and realizes the synergistic effect of multiple functions such as emergency, anti-adhesion, strong stability, antibiosis and repair promotion.

The application relates to the field of foam dressings, in particular to a wet medical polyurethane foam dressing and a preparation process thereof. The raw material scheme of the wet medical polyurethane foam dressing comprises polyurethane prepolymer, deionized water, a hydrophilic auxiliary agent, a chain extender, a gel catalyst, a foaming catalyst and a reinforcing agent and the like. The wet medical polyurethane foam dressing provided by the application has excellent comprehensive use performance. After absorbing a large amount of wound exudate, the dressing can still firmly lock the liquid under pressure, significantly inhibits the reverse osmosis phenomenon, and avoids the immersion damage of the skin around the wound. Meanwhile, the dressing has good flexibility and wet structure integrity, can be used in conformity with the wound contour, is not easy to adhere to the new tissue when being replaced, the stable long-acting liquid absorption capacity helps to prolong the replacement period, reduces the nursing workload and medical cost, and provides a more reliable and efficient solution for exudative wound management.

A wound exudate management system includes a pump for generating negative pressure, a dressing for covering and protecting a wound of a user, a tube including an interior lumen, the tube disposed between the pump and the dressing such that the pump and the dressing are in fluid communication via the interior lumen. The dressing includes an adhesive layer for adhering the dressing adjacent the wound, a wound contact layer, a pressure dispersion layer, a plurality of layers of absorbent material disposed between the wound contact layer and the pressure dispersion layer, a backing layer having a first surface and a second surface, the first surface of the backing layer being adjacent, and in contact with, the pressure dispersion layer and the adhesive layer, and a flexible connector disposed on the second surface of the backing layer.

The invention belongs to the technical field of fiber materials, and particularly relates to a sequential bidirectional drainage-cooling integrated material with a sandwich structure as well as a preparation method and application of the sequential bidirectional drainage-cooling integrated material. The material is composed of an upper hydrophobic antibacterial drainage layer capable of guiding liquid in one direction, a middle hydrophilic cooling layer and a lower hydrophobic antibacterial drainage layer capable of guiding liquid in one direction. According to the invention, the sequential bidirectional liquid guiding-cooling integrated material with a sandwich structure is successfully prepared through an electrohydrodynamic atomization technology; the liquid guiding performance of the upper hydrophobic antibacterial drainage layer and the lower hydrophobic antibacterial drainage layer is clearly observed by means of fluorescent dyeing in combination with a static contact angle measuring instrument. The material disclosed by the invention not only can guide away liquid between finger seams, chelidonium and abdominal folds, but also shows an obvious cooling effect, and the skin temperature can be reduced by 6.7 DEG C to the minimum extent. Meanwhile, vertical guide and separation of wound exudate are achieved, the excessive edema symptom of wound tissue is effectively relieved, and wound healing is achieved through antibiosis, anti-inflammation, vascularization promotion and collagen deposition promotion.

An exemplary wound dressing generally includes a wound-contacting layer and a sensor array. The sensor array is positioned distally of the wound-contacting layer, and generally includes a substrate, a first sensor positioned on the substrate, and a second sensor positioned on the substrate. The second sensor surrounds the first sensor, and each of the first sensor and the second sensor has a corresponding and respective electrical characteristic that varies in response to contact with wound exudate.

A system, method, and apparatus are disclosed for dressing a wound. The apparatus comprises a liquid and gas permeable transmission layer, an absorbent layer for absorbing wound exudate, the absorbent layer overlying the transmission layer, a gas impermeable cover layer overlying the absorbent layer and comprising a first orifice, wherein the cover layer is moisture vapor permeable.

This disclosure relates to a wound care device which contains capillary force one-way pumps that are capable of transporting fluid, such as wound exudate, away from a wound site to the opposite side of the wound care device, which functions as a segregated fluid reservoir. This fluid transport mechanism generally aids in reducing wound maceration by removing excess wound fluid and the protease enzymes and infectious bacteria contained within the wound fluid. The wound care device performs this function, often times for multiple days, without the loss of the physical integrity of the wound care device. In addition to providing a uni-directional fluid transport mechanism, the wound care device contains a perforated adhesive layer.

A wound exudate management system includes a pump for generating negative pressure, a dressing for covering and protecting a user's wound, and a tube including an internal lumen, the tube disposed between the pump and the dressing such that the pump and the dressing are in fluid communication via the internal lumen. The dressing includes an adhesive layer for adhering the dressing proximate to the wound, a wound contact layer, a pressure distribution layer, a multi-layer absorbent material disposed between the wound contact layer and the pressure distribution layer, a backing layer having a first surface and a second surface, the first surface of the backing layer adjacent to and in contact with the pressure distribution layer and the adhesive layer, and a flexible connector disposed on the second surface of the backing layer.

The invention discloses a bioactive fibrous membrane dressing for surgical wound healing and a preparation method thereof, belongs to the technical field of medical instruments, and solves the problems that the extraction and preparation cost of growth factors of existing bioactive dressings is relatively high, the stability in a wound environment is relatively poor, and the bioactive fibrous membrane dressing is easy to inactivate. The dressing is a bioactive nanofiber membrane dressing loaded with hUCMSCs, and the dressing is prepared from the following raw materials: a spinning solution, cerium dioxide nanoparticles, 10% fetal calf serum and a stem cell solution, the bioactive fibrous membrane dressing for healing the surgical wound, prepared by the invention, has excellent mechanical properties and can be well attached to the dynamic wound. Besides, the characteristics of high specific surface area and high porosity are utilized, wound exudate is effectively absorbed, good air permeability can be guaranteed, an ideal wound healing environment can be created, the synergistic effect of antibacterial and regeneration functions is achieved, and wound healing is effectively promoted.

This invention discloses a UV-crosslinked regenerated silk fibroin hydrogel fiber, its preparation method, and its applications. Using silk fibroin as the main raw material, the silk fibroin is first regenerated to obtain regenerated silk fibroin. Then, the regenerated silk fibroin fibers are collected using electrospinning and a rotating collection roller. These fibers are then soaked in a solution containing a photoinitiator and placed under UV light for crosslinking to form regenerated silk fibroin hydrogel fibers. Finally, the fibers are washed and soaked to obtain the regenerated silk fibroin hydrogel fiber. The advantages are: good mechanical strength and softness, suitable for use as wound dressings or tissue scaffolds; high water content and good swelling properties, capable of absorbing wound exudate; the hydrogel fiber membrane has good drug release performance, can be loaded with drugs for antibacterial or wound repair promotion; it has excellent biocompatibility and mechanical properties, and has broad application prospects as a drug carrier and tissue repair material in tissue engineering and drug release fields.

The invention provides a multi-layer composite dressing for chronic wound nursing, and belongs to the technical field of biological materials, the dressing comprises a breathable waterproof backing layer, a hydrophilic absorption pad layer and a wound contact layer which are stacked in sequence; the controlled-release bearing layer is arranged on the waterproof backing layer and the hydrophilic absorption layer, and comprises a porous fiber matrix and ternary composite nanoparticles loaded on the porous fiber matrix; the ternary composite nanoparticles are formed by self-assembly of metal ions, polyphenol compounds and quaternary ammonium salt compounds. The controlled-release bearing layer is configured to guide wound exudate to directionally flow from the wound contact layer to the hydrophilic absorption pad layer through a porous structure inside the controlled-release bearing layer and continuously release bioactive ions. The dressing can effectively manage exudate, inhibit microbial proliferation, relieve inflammatory response and promote chronic wound healing.

The invention discloses a pH-responsive onion-stripped drug delivery hydrogel and a preparation method and application thereof, and belongs to the technical field of high polymer materials. A dynamic covalent network is formed through a Schiff base reaction of an aldehyde-containing polymer and methacrylated gelatin, doxorubicin hydrochloride is carried, acrylamide is introduced, and the pH-responsive onion-stripped drug delivery hydrogel is prepared. The pH-responsive onion-stripped type drug delivery hydrogel is prepared by adopting a photocuring mode and directly acts on a focus part. The hydrogel disclosed by the invention has a loose and porous network structure and excellent adhesiveness, and can be attached to a postoperative bleeding part, absorb wound exudate and prevent postoperative massive hemorrhage. The hydrogel disclosed by the invention has pH responsiveness and slow biodegradation characteristics, can respond to a tumor subacid environment, so that a medicine is released layer by layer like an onion stripping mode, slow and lasting release of the medicine is realized at local parts of focuses, and the hydrogel can be used as a novel medicine delivery carrier and is used for inhibiting postoperative recurrence of different cancers such as prostatic cancer.

The invention relates to the technical field of medical treatment, in particular to anal fistula postoperative wound dressing change equipment and a dressing change method. The method comprises the following steps: acquiring three-dimensional shape data and wound exudate characteristic data; constructing a wound digital evaluation model based on the three-dimensional form data and wound exudate characteristic data, and performing judgment to obtain a wound healing stage judgment result; dressing change scheme parameters are selected according to the wound healing stage judgment result; a personalized dressing change execution instruction is generated based on the selected dressing change scheme parameters, and the automatic dressing change process of wound debridement, liquid medicine perfusion and dressing coverage is completed; after the dressing change process is completed, the three-dimensional shape data of the wound and the wound surface exudate characteristic data are collected again and compared and analyzed with the corresponding data before dressing change, and wound healing progress parameters are calculated; and performing dynamic adjustment according to the wound healing progress parameters to form a closed-loop dressing change optimization mechanism. By means of the device, the accuracy of wound dressing change after anal fistula operation can be improved.

The invention relates to the technical field of sterile treatment towels, and discloses a sterile treatment towel for a central venous catheter and a wrapping method thereof.The sterile treatment towel for the central venous catheter comprises a towel body which is divided into a core area, a first folding area, a second folding area and a third folding area; the guide assembly is used for prompting the step of folding the towel body; the observation assembly is used for observing the core area after the towel body is folded; the fixing assembly is used for fixing the catheter connector; and the prompting assembly is used for prompting medical staff when the wound exudates. Through partition arrangement of the towel body, the catheter connector has an exclusive placement and operation space, the towel body can be accurately folded along a preset track, and the technical effects that it is guaranteed that the catheter connector and a wound are in a closed sterile environment, and the wrapping accuracy is improved are achieved; through the arrangement of the guide assembly, green medical staff can fold all the areas in sequence according to specific steps, and the technical effects of shortening the operation time and improving the working efficiency are achieved.

The invention relates to a wound surface treatment agent and a preparation method thereof, and relates to the technical field of medical instruments, polyvinylpyrrolidone (PVP) is adopted to carry out organic molecule inclusion and stabilization on chlorine dioxide, so that chlorine dioxide keeps a dissolved state and chemical stability in a physiologically compatible weakly alkaline solution, and can be directly used without acidic activation; therefore, chemical stimulation of acid to the wound surface is avoided. When the stable system is in contact with wound exudate, the stable system can gradually release chlorine dioxide molecules with strong oxidation activity under the action of a body fluid ion environment, and a broad-spectrum and efficient antibacterial effect is locally played on a wound. Meanwhile, the released chlorine dioxide can promote the local blood coagulation process through the oxidation effect, and the healing process is facilitated. On the basis, the comprehensive performance is further enhanced through dosage form design, the effects of rapidly astringing wounds, reducing infection and promoting healing are achieved, and meanwhile the skin wound dressing is suitable for nursing skin wounds with different characteristics.

The utility model discloses a breathable adhesive bandage, which belongs to the technical field of adhesive bandages and comprises a base band, two sides of the base band are connected with reinforcing bands, the reinforcing bands are provided with breathable holes, the reinforcing bands are fixedly connected with fixing strips, the fixing strips are connected with sticking blocks, the reinforcing bands are fixedly connected with absorption pads, and the base band is connected with liquid medicine cotton. According to the utility model, the sticking blocks circularly distributed on the fixing strips effectively ensure the sticking firmness, meanwhile, the circular single-point sticking blocks ensure the convenience of secondary positioning, the plurality of groups of fixing strips are matched with the sticking blocks to ensure the tightness of fitting with the skin, and the breathing holes are matched with the absorption pad, so that the breathing effect is improved. The skin around the wound can breathe normally, the skin problem and wound infection risk caused by stuffiness and moisture are reduced, the air permeability of the wound is guaranteed, wound exudate and external liquid can be effectively absorbed by using the absorption pad, and a good environment is created for wound healing.