94 results about "Wound.exudate" patented technology

Disclosed herein are devices, wound dressings and methods for determining the pH of fluid or a wound exudate at a wound. Example devices include a device comprising a surface configured to contact the fluid or wound and a pH indicator covalently bound thereto or applied to the surface, wherein the pH indicator has a first colour prior to contact with the fluid or the wound exudate and changes colour as a function of the pH of the fluid or wound exudate. Example devices include a device which indicates wound exudate loading within a wound dressing and wound dressing comprising an absorbent layer and a moisture indicator which indicates would exudate loading within the dressing, wherein the visibility of the moisture indictor changes as a result of a physical transformation of a first material within the dressing. Systems, devices, and methods are provided for monitoring wound status and progression by measuring pH levels indicated by pH-sensitive wound dressings. In some implementations, a wound is monitored by capturing an image of the pH-sensitive wound dressing and processing the captured image to determine the color of a pH indicator included on the wound dressing. The color of the indicator is determined in terms of RGB values from the image, and a pH value for the wound dressing is calculated from the dressing RGB values. The calculated pH value is then relayed to a user to be used as an indicator of wound status or health.

The invention discloses a preparation method of a fibroin / collagen composite sponge for chronic wound repair, which comprises the following steps: S1, freeze-drying a silk fibroin solution with the mass concentration of 0.02-0.07 g / mL to obtain a silk fibroin sponge; s2, immersing the silk fibroin sponge into an alcohol solution for incubation, and then washing and drying to obtain insoluble silk fibroin sponge; and S3, immersing the insoluble silk fibroin sponge into a collagen solution with the mass concentration of 0.001-0.006 g / mL and the pH value of 5.0-5.5, so that after the insoluble silk fibroin sponge absorbs the collagen solution, freeze-drying to prepare the fibroin / collagen composite sponge. The fibroin / collagen composite sponge prepared by the method has excellent water binding capacity, moisture permeability and water retention capacity, can effectively remove wound exudate, adjust and maintain a wet healing environment, also can actively induce tissue regeneration and promote wound healing, and can meet the use requirements of chronic wounds on ideal wound dressing materials.

The invention relates to a dressing (16) for use in the negative pressure therapy of wounds, having: a wound contact layer (28); an air-impermeable top layer (34), wherein a receiving space (36) is formed between the top layer and the wound contact layer, wherein the wound contact layer is designed such that it is liquid-permeable and draws wound exudate from the wound into the receiving space, and wherein a connection opening (26) is formed in the top layer; and at least one distribution layer (50) arranged in the receiving space, wherein the distribution layer extends in two surface directions (X, Y) and is designed to distribute wound exudate in the surface directions. According to the invention, the distribution layer is formed by a flat material web portion (52), a first side (56) of the flat material web portion is designed as a structure defined by elevations (60) that are formed integrally with a plane (54) of the flat material web portion, a terminal through-opening (64) is formed in at least some of the elevations, and a cohesive intermediate space (66) is formed between the elevations.

The present application relates to an evaluation system for medical dressings, comprising a suction unit, a collection unit, a detection unit and a processing unit, the suction unit, which is in communication with a medical dressing covering a wound of a patient, is capable of transmitting negative pressure to the medical dressing and pumping wound exudate out of the medical dressing in the form of a fluid, the processing unit, based on detection results obtained by one or more detection components in the detection unit, adjusts a preset time period for the activation of the collection unit, wherein the activation of the collection unit is at least automatically controlled based on the preset time period and / or manually controlled based on a switch of a treatment program. The evaluation system is used to determine the actual use of a medical dressing in a treatment work for different categories of wounds, so as to obtain the expected use of any medical dressing in a treatment work for a specified category of wounds.

A system, method, and apparatus are disclosed for dressing a wound. The apparatus comprises a liquid and gas permeable transmission layer, an absorbent layer for absorbing wound exudate, the absorbent layer overlying the transmission layer, a gas impermeable cover layer overlying the absorbent layer and comprising a first orifice, wherein the cover layer is moisture vapor permeable.

The invention discloses a preparation method of metal zinc-curcumin complex doped alginate-based antibacterial hydrogel, which comprises the following steps: preparing a metal zinc-curcumin complex by utilizing the coordination effect between metal zinc ions and curcumin molecules, and then mixing and reacting the metal zinc-curcumin complex with a hydroxyapatite nano material to prepare a composite nano material. And preparing a dispersion liquid from the obtained composite nano material, adding polyvinyl alcohol and sodium alginate, stirring and mixing, and adding CaCl2 for crosslinking, thereby obtaining the alginate-based antibacterial hydrogel. The metal zinc-curcumin complex is doped, so that the obtained hydrogel has good antibacterial performance, and the obtained hydrogel has a communicated macroporous structure, so that the absorption capacity of the material to wound exudate can be remarkably improved, a necessary space channel can be provided for migration and adhesion of fibroblasts, and the wound exudate can be effectively absorbed. The method is crucial for maintaining long-term stability of a chronic wound environment and promoting wound healing, so that the method has a good application prospect.

The invention relates to the technical field of dressings, in particular to a recombinant collagen wound dressing and a preparation method thereof. The dressing is of a film-like structure and is prepared from the following raw materials: a selective methacrylated recombinant collagen concentrated solution, oxidized sodium hyaluronate and carboxymethyl chitosan. A collagen permanent cross-linked network is formed through visible light curing, and a multi-layer stable network is constructed by combining cross-linking between oxidized sodium hyaluronate and carboxymethyl chitosan and ion micro-cross-linking initiated by calcium ions. According to the preparation method, the methylacryloylation degree is accurately controlled, and the component adding time sequence (especially surface atomization and infiltration of carboxymethyl chitosan) is optimized, so that the good processability of a precursor is ensured; and the final product can still maintain excellent wet mechanical properties, form stability, liquid management capability and mild dressing change compliance after absorbing wound exudate.

The application provides a preparation method and application of a high-efficiency emergency antibacterial dressing and belongs to the technical field of biomedical materials. The high-efficiency emergency antibacterial dressing is prepared through a systematic process of alcohol-free wet spinning, secondary traction stretching, vacuum freeze drying, semi-dry state rapid carboxymethylation and needle punching / water jetting into cloth. The high-efficiency emergency antibacterial dressing has high mechanical strength and strong liquid absorption capacity, can absorb a large amount of wound exudate and keep the wound moist, and realizes the synergistic effect of multiple functions such as emergency, anti-adhesion, strong stability, antibiosis and repair promotion.

The application relates to the field of foam dressings, in particular to a wet medical polyurethane foam dressing and a preparation process thereof. The raw material scheme of the wet medical polyurethane foam dressing comprises polyurethane prepolymer, deionized water, a hydrophilic auxiliary agent, a chain extender, a gel catalyst, a foaming catalyst and a reinforcing agent and the like. The wet medical polyurethane foam dressing provided by the application has excellent comprehensive use performance. After absorbing a large amount of wound exudate, the dressing can still firmly lock the liquid under pressure, significantly inhibits the reverse osmosis phenomenon, and avoids the immersion damage of the skin around the wound. Meanwhile, the dressing has good flexibility and wet structure integrity, can be used in conformity with the wound contour, is not easy to adhere to the new tissue when being replaced, the stable long-acting liquid absorption capacity helps to prolong the replacement period, reduces the nursing workload and medical cost, and provides a more reliable and efficient solution for exudative wound management.

An exemplary wound dressing generally includes a wound-contacting layer and a sensor array. The sensor array is positioned distally of the wound-contacting layer, and generally includes a substrate, a first sensor positioned on the substrate, and a second sensor positioned on the substrate. The second sensor surrounds the first sensor, and each of the first sensor and the second sensor has a corresponding and respective electrical characteristic that varies in response to contact with wound exudate.

This disclosure relates to a wound care device which contains capillary force one-way pumps that are capable of transporting fluid, such as wound exudate, away from a wound site to the opposite side of the wound care device, which functions as a segregated fluid reservoir. This fluid transport mechanism generally aids in reducing wound maceration by removing excess wound fluid and the protease enzymes and infectious bacteria contained within the wound fluid. The wound care device performs this function, often times for multiple days, without the loss of the physical integrity of the wound care device. In addition to providing a uni-directional fluid transport mechanism, the wound care device contains a perforated adhesive layer.

A wound exudate management system includes a pump for generating negative pressure, a dressing for covering and protecting a user's wound, and a tube including an internal lumen, the tube disposed between the pump and the dressing such that the pump and the dressing are in fluid communication via the internal lumen. The dressing includes an adhesive layer for adhering the dressing proximate to the wound, a wound contact layer, a pressure distribution layer, a multi-layer absorbent material disposed between the wound contact layer and the pressure distribution layer, a backing layer having a first surface and a second surface, the first surface of the backing layer adjacent to and in contact with the pressure distribution layer and the adhesive layer, and a flexible connector disposed on the second surface of the backing layer.

The invention discloses a bioactive fibrous membrane dressing for surgical wound healing and a preparation method thereof, belongs to the technical field of medical instruments, and solves the problems that the extraction and preparation cost of growth factors of existing bioactive dressings is relatively high, the stability in a wound environment is relatively poor, and the bioactive fibrous membrane dressing is easy to inactivate. The dressing is a bioactive nanofiber membrane dressing loaded with hUCMSCs, and the dressing is prepared from the following raw materials: a spinning solution, cerium dioxide nanoparticles, 10% fetal calf serum and a stem cell solution, the bioactive fibrous membrane dressing for healing the surgical wound, prepared by the invention, has excellent mechanical properties and can be well attached to the dynamic wound. Besides, the characteristics of high specific surface area and high porosity are utilized, wound exudate is effectively absorbed, good air permeability can be guaranteed, an ideal wound healing environment can be created, the synergistic effect of antibacterial and regeneration functions is achieved, and wound healing is effectively promoted.

The invention provides a multi-layer composite dressing for chronic wound nursing, and belongs to the technical field of biological materials, the dressing comprises a breathable waterproof backing layer, a hydrophilic absorption pad layer and a wound contact layer which are stacked in sequence; the controlled-release bearing layer is arranged on the waterproof backing layer and the hydrophilic absorption layer, and comprises a porous fiber matrix and ternary composite nanoparticles loaded on the porous fiber matrix; the ternary composite nanoparticles are formed by self-assembly of metal ions, polyphenol compounds and quaternary ammonium salt compounds. The controlled-release bearing layer is configured to guide wound exudate to directionally flow from the wound contact layer to the hydrophilic absorption pad layer through a porous structure inside the controlled-release bearing layer and continuously release bioactive ions. The dressing can effectively manage exudate, inhibit microbial proliferation, relieve inflammatory response and promote chronic wound healing.

The invention discloses a pH-responsive onion-stripped drug delivery hydrogel and a preparation method and application thereof, and belongs to the technical field of high polymer materials. A dynamic covalent network is formed through a Schiff base reaction of an aldehyde-containing polymer and methacrylated gelatin, doxorubicin hydrochloride is carried, acrylamide is introduced, and the pH-responsive onion-stripped drug delivery hydrogel is prepared. The pH-responsive onion-stripped type drug delivery hydrogel is prepared by adopting a photocuring mode and directly acts on a focus part. The hydrogel disclosed by the invention has a loose and porous network structure and excellent adhesiveness, and can be attached to a postoperative bleeding part, absorb wound exudate and prevent postoperative massive hemorrhage. The hydrogel disclosed by the invention has pH responsiveness and slow biodegradation characteristics, can respond to a tumor subacid environment, so that a medicine is released layer by layer like an onion stripping mode, slow and lasting release of the medicine is realized at local parts of focuses, and the hydrogel can be used as a novel medicine delivery carrier and is used for inhibiting postoperative recurrence of different cancers such as prostatic cancer.

The invention relates to the technical field of medical treatment, in particular to anal fistula postoperative wound dressing change equipment and a dressing change method. The method comprises the following steps: acquiring three-dimensional shape data and wound exudate characteristic data; constructing a wound digital evaluation model based on the three-dimensional form data and wound exudate characteristic data, and performing judgment to obtain a wound healing stage judgment result; dressing change scheme parameters are selected according to the wound healing stage judgment result; a personalized dressing change execution instruction is generated based on the selected dressing change scheme parameters, and the automatic dressing change process of wound debridement, liquid medicine perfusion and dressing coverage is completed; after the dressing change process is completed, the three-dimensional shape data of the wound and the wound surface exudate characteristic data are collected again and compared and analyzed with the corresponding data before dressing change, and wound healing progress parameters are calculated; and performing dynamic adjustment according to the wound healing progress parameters to form a closed-loop dressing change optimization mechanism. By means of the device, the accuracy of wound dressing change after anal fistula operation can be improved.

The invention relates to a wound surface treatment agent and a preparation method thereof, and relates to the technical field of medical instruments, polyvinylpyrrolidone (PVP) is adopted to carry out organic molecule inclusion and stabilization on chlorine dioxide, so that chlorine dioxide keeps a dissolved state and chemical stability in a physiologically compatible weakly alkaline solution, and can be directly used without acidic activation; therefore, chemical stimulation of acid to the wound surface is avoided. When the stable system is in contact with wound exudate, the stable system can gradually release chlorine dioxide molecules with strong oxidation activity under the action of a body fluid ion environment, and a broad-spectrum and efficient antibacterial effect is locally played on a wound. Meanwhile, the released chlorine dioxide can promote the local blood coagulation process through the oxidation effect, and the healing process is facilitated. On the basis, the comprehensive performance is further enhanced through dosage form design, the effects of rapidly astringing wounds, reducing infection and promoting healing are achieved, and meanwhile the skin wound dressing is suitable for nursing skin wounds with different characteristics.

The utility model discloses a breathable adhesive bandage, which belongs to the technical field of adhesive bandages and comprises a base band, two sides of the base band are connected with reinforcing bands, the reinforcing bands are provided with breathable holes, the reinforcing bands are fixedly connected with fixing strips, the fixing strips are connected with sticking blocks, the reinforcing bands are fixedly connected with absorption pads, and the base band is connected with liquid medicine cotton. According to the utility model, the sticking blocks circularly distributed on the fixing strips effectively ensure the sticking firmness, meanwhile, the circular single-point sticking blocks ensure the convenience of secondary positioning, the plurality of groups of fixing strips are matched with the sticking blocks to ensure the tightness of fitting with the skin, and the breathing holes are matched with the absorption pad, so that the breathing effect is improved. The skin around the wound can breathe normally, the skin problem and wound infection risk caused by stuffiness and moisture are reduced, the air permeability of the wound is guaranteed, wound exudate and external liquid can be effectively absorbed by using the absorption pad, and a good environment is created for wound healing.

This utility model relates to a composite dressing, comprising: an adhesive layer, mainly made of a hydrocolloid material, including an absorbent area with multiple drainage holes for covering the wound and a sealing area for covering the skin surrounding the wound; an absorbent layer, mainly made of a superabsorbent material, disposed on the side of the adhesive layer facing away from the wound to cover the absorbent area of ​​the adhesive layer, wherein the superabsorbent material absorbs at least ten times its own weight in wound exudate; and a backing layer, disposed to cover the absorbent layer and connected to the sealing area of ​​the adhesive layer on the side facing away from the wound. This composite dressing overcomes the shortcomings of existing single-type dressings that struggle to simultaneously achieve high absorbency and maintain a moist environment, effectively managing wound exudate and maintaining a moist healing environment.

This invention discloses a gellizable, dynamically adhesive, moist wound healing dressing and its preparation method and application. The dressing is constructed from water-soluble cellulose derivatives, chitosan derivatives, and silk fibroin through physical cross-linking and freeze-induced phase separation, achieving dry-state stability without the need for chemical cross-linking agents. Upon contact with wound exudate, a gel layer forms. With prolonged contact, the carboxyl, amino, and hydroxyl functional groups form a dynamic, reversible hydrogen bond and electrostatic interaction network with skin surface proteins, resulting in an adhesion interface strength lower than the external force required for peeling, thus achieving non-damaging peeling. Furthermore, the dressing possesses antibacterial properties and acts as a nutrient substrate to promote cell proliferation and tissue regeneration. This invention's dressing integrates gelation, moisturizing, dynamic adhesion, antibacterial, and nutritional healing functions, making it suitable for moist wound healing treatment of various skin wounds and providing a novel dressing for clinical wound care.

The invention provides a microcapsule wound dressing containing cannabidiol and a preparation method of the microcapsule wound dressing. The microcapsule wound dressing comprises polyurethane foam and functional microcapsules dispersed in the polyurethane foam. The functional microcapsule comprises a microcapsule matrix and cannabidiol located in the microcapsule matrix. The microcapsule matrix is urea resin. The microcapsule wound dressing has a stable structure in a dry environment, and when the microcapsule wound dressing is in contact with liquid such as blood, tissue fluid and the like, the urea-formaldehyde resin can be broken to release cannabidiol, so that wound healing is promoted. Meanwhile, the polyurethane foam can absorb wound exudate, the wound environment is kept stable, and wound healing is promoted. The microcapsule wound dressing is suitable for chronic wound nursing, such as diabetic foot ulcer, bedsore and the like.

The utility model discloses a leprosy patient foot ulcer seepage adsorption insole which comprises a macromolecule water absorption fiber insole body, a medical silica gel insole body is detachably arranged on the macromolecule water absorption fiber insole body, a plurality of seepage flow guide holes are formed in the medical silica gel insole body, and the seepage flow guide holes penetrate through the medical silica gel insole body. The insole has the advantages that wound exudate of a patient flows into the macromolecule water-absorbing fiber insole on the lower layer through the exudate flow guide holes, liquid retention on the surface of the insole is reduced, the wound is kept dry, and comfort is better. The medical silica gel insole is in contact with the foot of the patient, so that the comfort is better, and the pain of the patient is relieved. The detachable design is adopted between the macromolecule water-absorbing fiber insole and the medical silica gel insole, the macromolecule water-absorbing fiber insole can be independently detached after seepage adsorption is saturated, the medical silica gel insole can be repeatedly used after being cleaned and aired, and the long-term use cost is reduced.

The hydrophilic and hydrophobic Janus membrane comprises a hydrophobic fiber layer and a hydrophilic fiber layer loaded with metal-ellagic acid nanoparticles, and the metal-ellagic acid nanoparticles comprise ellagic acid and metal ions which are connected through coordinate bonds. Metal-ellagic acid nanoparticles are synthesized through a self-assembly reaction, the particles are loaded on a hydrophilic fiber layer through a high-voltage electrostatic spinning technology, the hydrophilic and hydrophobic Janus membrane which can continuously release ellagic acid and has antioxidant, antibacterial and directional drainage and seepage functions is obtained, bacterial growth can be inhibited, the free radical level can be reduced, and the antibacterial effect can be improved. Meanwhile, wound exudate is led out. In addition, the Janus membrane loaded with the metal-ellagic acid nanoparticles can effectively promote the repair of granulation tissues, the deposition of wound collagen and the acceleration of the crawling of epithelium, and can inhibit the expression of MMP-9 at the wound of diabetes mellitus.

The invention discloses a hydrophilic fiber dressing as well as a preparation method and application thereof, and belongs to the technical field of dressings. The hydrophilic fiber dressing is non-woven fabric and comprises CMC hydrophilic fibers, calcium alginate fibers and sodium salt cellulose fibers, and the sodium salt cellulose fibers are cellulose fibers containing sodium salt; the hydrophilic fiber dressing is obtained by performing fiber mixing, opening, carding, cross lapping and needling on CMC hydrophilic fibers, calcium alginate fibers and sodium salt cellulose fibers. The hydrophilic fiber dressing is based on the CMC hydrophilic fiber, the calcium alginate fiber and the sodium salt cellulose fiber, when the hydrophilic fiber dressing is used, the CMC hydrophilic fiber can absorb a large amount of wound exudate to form gel, sodium salt is released and exchanges ion with the calcium alginate fiber, the imbibition capacity and the gelling effect of the calcium alginate fiber are improved, and the wound exudate can be effectively absorbed. The sodium salt release also improves the salt concentration of the seepage, improves the drainage effect of the CMC hydrophilic fiber, and has the effects of high drainage, high strength and high liquid absorption.

The present application relates to a kind of medical dressings containing high concentration lactic acid and its preparation method, belong to medical dressing technical field.The present application is combined by chemical crosslinking and ion coordination to carboxymethyl cellulose, solve the problem that medical dressing contact wound exudate contact gel leads to gel collapse, further through octadecyl methacrylate grafting carboxymethyl cellulose form hydrophobic core and double crosslinking carboxymethyl cellulose form hydrophilic shell;Octadecyl methacrylate long chain alkyl forms dense hydrophobic region, and hydrophilic shell is swollen by contacting wound exudate, not only further solve the problem of gel collapse, but also effectively control the release of lactic acid, promote wound healing.

The application discloses a flexible intelligent patch and method for in-situ monitoring of wound bacteria. The patch comprises a packaging adhesive layer, a control circuit, an electrode array and a wound exudate absorption layer. The control circuit and the electrode array are electrically connected through the electrode array connection pad to form a combined planar structure, which is embedded in the packaging adhesive layer. The wound exudate absorption layer is fixed to the lower surface of the electrode array package. The electrode array comprises a staphylococcus aureus transpeptidase sensing electrode and a pyocyanin sensing electrode. The application utilizes a near field communication module to realize wireless power supply and data interaction through a mobile terminal, and adopts an electrochemical analysis method to realize in-situ real-time measurement of wound exudate, so as to realize simultaneous monitoring of the infection conditions of staphylococcus aureus and pseudomonas aeruginosa in the wound. The patch provides an instant detection platform for the management of infected wounds, and has the advantages of flexible intelligence, real-time in-situ and convenient operation.

This invention discloses a chitosan-based wound adhesive for promoting healing and inhibiting scarring, and its preparation method. The adhesive employs a time-controlled release structure: an outer layer is a chitosan-Imperata cylindrica inflammatory response coating, and an inner layer is a polylactic acid-egg membrane, loaded with tranexamic acid and onion extract liposomes. Upon contact with wound exudate, the outer layer can solidify in situ in response to salt, rapidly stopping bleeding and relieving pain; in the acidic inflammatory microenvironment, the inner layer gradually degrades, with the egg membrane and tranexamic acid synergistically promoting epithelial regeneration and improving scar quality; onion extract inhibits excessive fibroblast proliferation and regulates orderly collagen deposition, preventing hypertrophic scars and pigmentation from the source. This invention primarily uses natural biomaterials, exhibiting excellent biocompatibility, and simultaneously achieves hemostasis, anti-inflammation, healing promotion, and scar inhibition throughout the entire treatment cycle, overcoming the shortcomings of traditional dressings such as uncontrollable drug release and limited functionality.