77 results about "Foot ulcer" patented technology

The invention discloses a lightweight diabetic foot ulcer image segmentation method and system, and relates to the technical field of medical image processing, and the specific steps are as follows: obtaining a to-be-segmented image, and preprocessing the to-be-segmented image to obtain a preprocessed image; inputting the pre-processed image into a pre-trained sugar foot ulcer image segmentation model to obtain a segmented image; wherein the sugar foot ulcer image segmentation model adopts an MC-UNet network architecture and comprises an encoder, an LSDE module and a decoder which are connected in sequence, and the LSDE module introduces a channel and space attention mechanism and a multi-head cross-axis attention mechanism so as to capture a long-distance dependency relationship in the preprocessed image and enhance feature expression. According to the method, the visual state space module group is used for multi-scale feature extraction, and an adaptive solution is provided for the diversity of the size and form of the diabetic foot ulcer area, so that the segmentation precision and stability are remarkably improved.

The invention belongs to the field of medical rehabilitation, and particularly discloses a diabetic foot ulcer patient non-load exercise rehabilitation exercise decision support system which comprises an evaluation grading module used for obtaining multi-mode ulcer data of a patient and scientifically grading diabetic foot ulcers of the patient in combination with a layering algorithm to obtain a grading result; the scheme generation module is used for matching a non-load exercise scheme suitable for the patient in a database according to the grading result and generating an initial exercise scheme; the exercise feedback module is used for sending the initial exercise scheme to a patient terminal, acquiring the exercise completion condition of the patient and performing personalized adjustment on the exercise intensity and frequency through a dynamic regulation and control mechanism; according to the method, static ulcer features and dynamic physiological features are combined through a multi-modal data fusion technology, automatic grading is realized based on an AI algorithm, and scientificity and consistency of grading evaluation are remarkably improved.

The invention discloses application of conductive hydrogel combined with electrical stimulation in treatment of diabetic foot ulcer caused by neuropathy, and belongs to the field of biological medicine. The conductive hydrogel is obtained by mixing chitosan, polyvinyl alcohol, MXene and gelatin; the chitosan is catechol group modified chitosan, the MXene is polyphenol and Mg ion modified MXene, the gelatin is phenylboronic acid modified gelatin, the electrical stimulation condition is 100 mV cm <-1 >, and the diabetic foot ulcer comprises diabetic foot ulcer caused by neuropathy. Experiments prove that the prepared conductive hydrogel can promote cell migration in combination with electrical stimulation, wound healing of the diabetic foot ulcer can be accelerated, functional repair can be achieved, and a new thought is provided for clinical treatment of the diabetic foot ulcer caused by neuropathy.

The invention discloses a pharmaceutical composition for treating diabetic foot ulcer in the technical field of medicine, the pharmaceutical composition comprises loropetalum chinense extract, angelica sinensis extract, liquorice extract, angelica dahurica extract and lithospermum erythrorhizon extract, and the application dosage form of the pharmaceutical composition is gel. A hydrogel carrier of the gel is antibacterial hydrogel which is formed by PDLA-CPC-PDLA and PLLA-PEG-PLLA through complexation, and the antibacterial hydrogel is adhered to an application capable of being heated by self; the antibacterial hydrogel is fixed on the surface of a wound through the application, the medicine is separated out from the hydrogel by utilizing the temperature difference between a patient and the application, and the medicine is accumulated on the surface of the wound, so that the absorption of the medicine by the wound is facilitated, and the healing process of the wound is accelerated.

The invention relates to the technical field of biomarkers, in particular to a biomarker composition for diabetic foot ulcer and application of the biomarker composition. The invention provides a biomarker combination for diabetic foot ulcer. The biomarker combination comprises a DDIT4 gene and a PKM gene. According to the invention, by integrating transcriptome sequencing data and single cell sequencing data, biomarkers DDIT4 and PKM closely related to diabetic foot ulcer (DFU) are successfully screened out. The expression of the two genes in a disease group is remarkably up-regulated, and the two genes are stably expressed in different data sets, so that a reliable molecular target is provided for early diagnosis of DFU.

The present application relates to the technical field of biological medicine, and particularly relates to a stem cell culture method for promoting wound healing and application thereof. The stem cell culture method for promoting wound healing comprises the following steps: step one, providing umbilical cord-derived mesenchymal stem cells; step two, adding luteolin and baicalin as culture medium additives in a serum-supplemented culture medium, wherein the concentration of luteolin is 1-10 micromoles / L, and the concentration of baicalin is 1-10 micromoles / L; step three, inoculating the mesenchymal stem cells into the culture medium containing the additives for culture, and the culture condition is 34-40 DEG C, 4-6% CO2, and the culture time is 48-96 hours; step four, harvesting the cultured mesenchymal stem cells to obtain stem cells for promoting wound healing. The culture method can promote the stem cells to secrete various growth factors, significantly improve the secretion of PGE2 and VEGF-C growth factors, and make the wound healing rate of the stem cell treatment group reach 96%, which has a significant effect on treating diabetic foot ulcers.

The invention discloses composite hydrogel, a preparation method and application of the composite hydrogel in preparation of a medicine for treating diabetic foot ulcer infection. The composite hydrogel comprises a methacrylated gelatin hydrogel and a cyclocarya paliurus extract product or cyclocarya paliurus leaf powder compounded in the methacrylated gelatin hydrogel. The dressing prepared by the invention realizes drug sustained release, which indicates that the hydrogel can promote long-term release of drugs, further reduce loss of liquid drugs and improve the utilization rate of the drugs, is used for inhibiting healing of diabetic foot ulcer infected wounds, and has wide clinical application prospects.

The invention provides a pharmaceutical composition for treating diabetic foot ulcer as well as a preparation method and application thereof, and the pharmaceutical composition for treating diabetic foot ulcer is prepared by taking angelica sinensis, honeysuckle and scutellaria baicalensis as raw materials through pretreatment, extraction and post-treatment. The pharmaceutical composition for treating diabetic foot ulcer disclosed by the invention has a good curative effect on diabetic foot ulcer diseases; especially, an oral prescription and an external prescription are matched for use, so that the curative effect is better.

In some aspects, a non-transitory computer readable medium is disclosed that has an application stored thereon that when executed by a processor of an electronic device causes the processor to perform a process. The process can include receiving motion data from a motion sensor, the motion data being indicative of motion by a user while wearing the motion sensor. The process can also include transmitting the motion data to a server, receiving from the server a time that the motion data indicates a foot of the user experienced a loading force which risked adversely impacting an existing foot ulcer or causing a new foot ulcer, determining a geographic location of the motion sensor at the time that the foot experienced the loading force, displaying the time and the geographic location, and requesting that the user identify an activity engaged in by the user at the time and the geographic location.

The present invention discloses the application of a conductive hydrogel combined with electrical stimulation in the treatment of diabetic foot ulcers caused by neuropathy, belonging to the field of biomedicine. The conductive hydrogel is obtained by mixing chitosan, polyvinyl alcohol, MXene and gelatin. The chitosan is chitosan modified with catechol groups, the MXene is MXene modified with polyphenols and Mg ions, and the gelatin is gelatin modified with phenylboronic acid. The condition of the electrical stimulation is 100 mV cm-1. The diabetic foot ulcers include diabetic foot ulcers caused by neuropathy. Through experimental verification, the conductive hydrogel prepared by the present invention combined with electrical stimulation can promote cell migration, accelerate the wound healing of diabetic foot ulcers and achieve functional repair. The present invention provides a new idea for the clinical treatment of diabetic foot ulcers caused by neuropathy.

The utility model discloses a diabetic foot ulcer treatment dressing change device, which comprises a shoe frame, a bottom plate and a detachable component, the inner surface of the shoe frame is fixedly connected with a breathable sheet, the lower surface of the breathable sheet is provided with a medicine pad, the inner part of the shoe frame is provided with a plug pin, and the plug pin is connected with the bottom plate. The detachable assembly comprises a first limiting block, a sliding block, a sliding column, a sleeve, a spring, a clamping block and a second limiting block, the inner wall of the first limiting block is slidably connected with the sliding block, the interior of the sliding block is fixedly connected with the sliding column, the side surface of the sliding column is slidably connected with the sleeve, and the sleeve penetrates through the interior of the spring; by means of the detachable assembly, the foot pad at the bottom of the foot mold can be replaced, a traditional adhesion type foot patch dressing change mode is replaced, mounting and dismounting operation is easy and convenient, pain of a patient in the dressing change process can be reduced, the comfort level of the patient is greatly improved, and high practicability is achieved.

The present invention belongs to the field of preparation of diabetes complication remission agents, and particularly relates to a combined preparation for improving microcirculation of diabetic foot and a preparation method thereof. Starting from platelet-rich plasma, the present invention obtains exosomes containing rich active substances such as growth factors through stimulation with calcium gluconate and the like, and loads protamine nanoparticles to obtain bioactive substances with strong antibacterial ability, which can resist the development process of diabetic foot ulcers. The present invention uses bioactive glass, hydroxyethyl cellulose and the like to stabilize the bioactive substances, prolong the in vitro lifespan of the bioactive substances, and modified carboxymethyl cellulose provides better biodegradation effect. The combined preparation prepared by the present invention has less cytotoxicity, better antibacterial effect, can promote wound healing quickly, and the microcirculation index shows that it can stimulate the change of foot blood flow and improve the condition of foot artery blockage, etc.

According to various embodiments, a server for predicting determination on a diabetic foot on the basis of a plurality of pieces of data on the basis of a prediction model, comprises: a communication interface; a memory; and a processor, wherein the processor is configured to: obtain at least one piece of image data and at least one piece of first sensing data from an external server of an external user through the communication interface; obtain first ulcer output data by inputting the at least one piece of image data and the at least one piece of first sensing data to the prediction model; when it is determined that the first ulcer output data exceeds a preset first threshold value on the basis of a result of comparing the first ulcer output data with the preset first threshold value, output that a foot ulcer of the external user is likely to be diabetic foot ulcer; when it is determined that the first ulcer output data exceeds a second threshold value set to be greater than the first threshold value on the basis of a result of comparing the first ulcer output data with the second threshold value, output that the foot ulcer of the external user is highly likely to be the diabetic foot ulcer; and transmit, through the communication interface, result data for the first ulcer output data determined to exceed the first threshold value and / or the second threshold value, and guideline data presenting at least one guideline on the basis of the result data, wherein the prediction model is trained on the basis of a plurality of pieces of image data, a plurality of pieces of first sensing data, and a plurality of pieces of second sensing data, which are obtained from a plurality of users, a plurality of pieces of result data output from the plurality of users, and at least one piece of professional opinion data obtained by observing the plurality of users.

The present application relates to a peptide-ionic liquid conjugate for the prevention and / or treatment of skin conditions. The peptide-ionic liquid conjugate comprises a pharmaceutical cosmetic peptide containing up to 10 amino acids and at least one ionic liquid containing a C1 to C18 saturated or unsaturated hydrocarbon chain substituent. The peptide-ionic liquid conjugates disclosed herein are useful for combating skin conditions, such as melanoma, non-melanoma skin cancer, diabetic foot ulcer, lower limb vein ulcer, stress ulcer, acne, candidiasis, cellulitis, dermatophytosis, erysipelas, folliculitis, impetigo, psoriasis, rosacea or eczema (atopic dermatitis), and the like. As they exhibit potent activity, bactericidal effect, anti-inflammatory and immunomodulatory effect and collagen production inducing effect on antibiotic sensitive strains or gram-positive and gram-negative multi-drug resistant clinical isolates. The present application further discloses topical compositions comprising the peptide-ionic liquid conjugates and uses thereof.

The invention relates to a degradable double-enzyme active nano-enzyme for treating diabetic foot ulcer, and aims to provide a novel efficient treatment scheme. The nano-enzyme has peroxidase-like and catalase-like dual-enzyme activity, is prepared by a specific chemical synthesis method, has good biodegradability, and can efficiently catalyze a reaction in a physiological environment to reduce drug resistance. Compared with a traditional treatment method, the nano-enzyme disclosed by the invention can be used for remarkably improving the treatment effect of the diabetic foot ulcer, accelerating the healing process and reducing the toxic and side effects on a human body and the manufacturing cost at the same time, and a safer and more effective treatment choice is provided for a patient with the diabetic foot ulcer.

The present invention is a diabetic healing system for the treatment of diabetic foot ulcers. This device promotes the healing process of diabetic foot ulcers by completely offloading the pressures that an ulcer may be subjected to regardless of its size, shape or location on the foot / ankle and / or toes. The device is made of a custom rigid outer shell and a custom inner lattice structure that fully supports, stabilizes and conforms to all aspects of a patient's condition, anomalies and disfigurement. It completely offloads (zero contact) any ulceration regardless of the location on the foot, ankle or toes. The offloading occurs through the use of recessed areas that can be incorporated directly into the lattice structure, or can be included in a "plug" that fits within a small aperture in the lattice structure.

The present invention belongs to the field of surface skin repair and wound treatment, and specifically relates to a new type of wound dressing, a preparation method and application thereof. The preparation method comprises: preparation and preliminary purification of hemoglobin, fine purification of hemoglobin, degassing treatment, virus inactivation, preparation of wound dressing stock solution and preparation of wound dressing. The wound dressing can be used for wound treatment on the skin surface, especially for the treatment of chronic wounds, especially for the treatment of chronic wounds with delayed healing for more than 8 weeks, especially for ulcers caused by basic metabolic diseases such as diabetes, neuropathic or ischemic ulcers, leg venous insufficiency, ulcers caused by external pressure after skin and tissue aging (such as pressure sores, bedsores), second-degree and below burns, frostbite, etc., especially foot ulcers caused by diabetes; it can also be used for scar repair on the skin surface, and can also be used for repairing difficult-to-heal wounds after surgery.

The invention provides a foot ulcer risk screening instrument based on artificial intelligence, and relates to the field of foot ulcer risk screening instruments. The foot ulcer risk screening instrument based on artificial intelligence comprises a foot screening instrument, three vertical grooves are formed in each of the two sides of the front end of the foot screening instrument, three threaded rotating rods are arranged at the front ends of the inner walls of the vertical grooves, sliding blocks are arranged on the inner walls of the vertical grooves in a sliding mode, and connecting blocks are arranged at the rear ends of the sliding blocks. Limiting plates are arranged on the two sides of the rear ends of the connecting blocks in the middles of the two sides, limiting side plates are arranged on the two sides of the rear ends of the two sides of the connecting blocks on the two sides, and a detection side plate is arranged between every two adjacent limiting side plates. According to the invention, reasonable layout of foot dorsum, foot side and sole detection components is realized, three types of screening cameras are respectively corresponding to different areas of the foot, a structural basis is provided for comprehensive screening of multiple parts, and the problem of insufficient coverage of non-sole areas in traditional screening is effectively avoided.

The invention discloses a volatile oil supported hydrogel composite material as well as a preparation method and application thereof, and belongs to the technical field of medicine preparation. The composite material comprises sporopollen microcapsules loaded with volatile oil, and hydrogel formed by crosslinking four-arm polyethylene glycol amine and four-arm polyethylene glycol succinimide glutarate. The preparation method comprises the following steps: degreasing plant pollen, carrying out acid treatment to obtain sporopollen microcapsules, mixing the sporopollen microcapsules with volatile oil, and then blending and cross-linking with a polyethylene glycol derivative solution. The composite material can efficiently load volatile oil, realizes long-acting slow release, has excellent antibacterial performance and an effect of promoting wound healing, and can be used for treating chronic wounds such as diabetic foot ulcer and the like.

The invention relates to the field of rehabilitation medical treatment, in particular to exercise rehabilitation auxiliary wearable equipment suitable for diabetics and obese patients, which comprises a single chip microcomputer and a plantar pressure adjusting assembly, the plantar pressure adjusting assembly comprises an insole, a plurality of openings are formed in the insole, and a plurality of elastic membranes used for sealing the openings are fixedly connected to the top of the insole; the insole is provided with a sensing assembly used for monitoring plantar pressure, and the sensing assembly is located below the elastic membrane and is in signal connection with the single-chip microcomputer. The bottom of the insole is fixedly connected with a substrate layer, a plurality of air cavities are formed in the substrate layer, and the air cavities are communicated with the adjacent openings; folding assemblies used for enhancing the supporting rigidity of the elastic membranes are arranged in the air cavities. By collecting plantar pressure data and regulating and controlling the supporting rigidity of the elastic membrane and the folding assembly, dynamic adaptation of the plantar supporting rigidity is achieved, the risks of foot ulcers of diabetic patients and plantar strain of obese patients are reduced, and comfort and safety in the exercise rehabilitation process are improved.

The utility model discloses a diabetic foot ulcer wound dressing plaster which comprises a pair of shaping plaster bodies attached to the ankle portion and a connecting band used for connecting the pair of shaping plaster bodies, elastic bands are arranged on the two sides of one shaping plaster body respectively, absorption dressing is arranged in the center of the other shaping plaster body, adjusting buckles are arranged on the two sides of the absorption dressing, and the elastic bands are connected with the connecting band. And the adjusting buckle is connected with the elastic band so as to adjust the tightness of the elastic band. The dressing paste suitable for the ankle joint is composed of the shaping paste, the connecting bands, the absorbing dressing and the elastic bands, the connecting bands at the bottom are connected around the foot bottom, the elastic bands on the two sides are connected around the ankle, a stable fixing system is formed, the dressing paste can be kept at the correct position when a patient walks and moves, and the dressing paste is suitable for the ankle joint. Therefore, stable protection is provided for the wound continuously.

The invention discloses a traditional Chinese medicine composition for treating long-term ulceration of trauma and a preparation method thereof, and relates to the technical field of traditional Chinese medicine, and the composition is prepared by compatibility of four medicinal materials including hairyvein agrimony charcoal, dragon bone calcined powder, scorched licorice powder and indigo naturalis powder through a special processing technology. The preparation method adopts a step-by-step temperature control calcining method and an equivalent incremental mixing method, so that stable release of pharmacodynamic substances is ensured. Clinical research shows that the composition can reduce the exudation of a traumatic exudate wound within 7 days by 83%, shorten the healing period of diabetic foot ulcer by 40%, and realize the synergistic effect of antibiosis and tissue regeneration by adjusting the pH value of a wound microenvironment. A quality control system covers 12 core indexes such as tannin and calcium ions, the accuracy is improved by more than 3 times compared with that of a traditional preparation, and a safe and effective traditional Chinese medicine solution is provided for refractory wounds.

The invention relates to the technical field of biological medicine, in particular to a stem cell culture method capable of promoting wound healing and application thereof. The stem cell culture method capable of promoting wound healing comprises the following steps: step 1, providing umbilical cord-derived mesenchymal stem cells; 2, luteolin and baicalin are added into the serum supplement culture medium to serve as culture medium additives, the concentration of the luteolin is 1-10 [mu] mol / L, and the concentration of the baicalin is 1-10 [mu] mol / L; 3, inoculating the mesenchymal stem cells into a culture medium containing an additive, and culturing for 48-96 hours under the culture conditions that the temperature is 34-40 DEG C, the CO2 content is 4-6% and the culture time is 48-96 hours; 4, the cultured mesenchymal stem cells are harvested, and the stem cells capable of promoting wound healing are obtained. According to the culture method, stem cells can be promoted to secrete multiple growth factors, secretion of PGE2 and VEGF-C growth factors is remarkably improved, the wound healing rate of a stem cell treatment group is increased to 96%, and the culture method has a remarkable effect on treating diabetic foot ulcer.

The application discloses a functional low-frequency responsive piezoelectric hydrogel as well as a preparation method and application thereof, and belongs to the field of biomedical technology.The application provides the functional low-frequency responsive piezoelectric hydrogel in view of the defects of the existing piezoelectric hydrogel in the treatment of diabetic wound surfaces.The hydrogel has two forms, one is a temperature-sensitive piezoelectric hydrogel, and the other is a spray type piezoelectric hydrogel.Both the two gels are doped with a PVP modified piezoelectric catalytic material ZnO-CuO, which not only has a strong killing effect on bacteria and generates an electric signal, but also has a great effect on blood vessel formation and cell migration.The developed hydrogel can generate an electric signal to adjust the electrophysiological microenvironment of a wound surface, thereby affecting the behaviors of various cells and bacteria.The low-frequency responsive hydrogel with a piezoelectric enhancement effect can effectively accelerate the healing of a diabetic foot ulcer wound surface by promoting blood vessel regeneration and inhibiting bacterial infection, and provides a new idea for the application of a high-performance piezoelectric catalyst in the field of biomedicine.

This invention discloses a strain of Codonopsis pilosula endophytic fungus that produces extracellular polysaccharides and its applications. This Codonopsis pilosula endophytic fungus is a short-spore bacterium, named... Brevibacillus schisleri CpRG-1. The Codonopsis pilosula endophytic bacteria of the present invention exhibit excellent ability to produce extracellular polysaccharides, producing high concentrations of extracellular polysaccharides, which can greatly reduce the cost of extracting polysaccharides from the medicinal herb Codonopsis pilosula; at the same time, the extracellular polysaccharides produced by the Codonopsis pilosula endophytic bacteria not only have antibacterial and hypoglycemic activities, but also can promote the healing of diabetic foot ulcers and improve the intestinal microbiota, providing new ideas for the development of antibacterial drugs, diabetes prevention foods and drugs, and diabetic foot ulcer treatment foods and drugs.

The invention relates to the field of medical treatment and health, and discloses a diabetic foot ulcer electrical stimulation and medicine synergistic treatment device and a using method, the diabetic foot ulcer electrical stimulation and medicine synergistic treatment device comprises a flexible main body belt, the two sides of the flexible main body belt are both provided with binding belts, the surface of the left binding belt is provided with a hook face hook-and-loop fastener, and the surface of the right binding belt is provided with a suede face hook-and-loop fastener; and the electrical stimulation drug delivery synergistic structure is used for integrating electrical stimulation and transdermal drug delivery, so that the rehabilitation treatment of the foot ulcer is enhanced. Organic fusion of treatment means is achieved through an electrical stimulation drug delivery synergistic structure, and the limitation of single treatment is broken through: a platinum composite flexible electrode and a gold composite flexible electrode are matched with an electrical stimulation control module, wound surface microcirculation can be improved through low-frequency electrical stimulation, and meanwhile, a blood vessel dilating agent stored in a drug storage chamber can further enhance the microcirculation improvement effect; the anti-inflammatory drug can reduce local inflammatory response possibly caused by electrical stimulation, and the synergistic effect of stimulation synergy and drug side effect reduction is achieved.

The utility model discloses a leprosy patient foot ulcer seepage adsorption insole which comprises a macromolecule water absorption fiber insole body, a medical silica gel insole body is detachably arranged on the macromolecule water absorption fiber insole body, a plurality of seepage flow guide holes are formed in the medical silica gel insole body, and the seepage flow guide holes penetrate through the medical silica gel insole body. The insole has the advantages that wound exudate of a patient flows into the macromolecule water-absorbing fiber insole on the lower layer through the exudate flow guide holes, liquid retention on the surface of the insole is reduced, the wound is kept dry, and comfort is better. The medical silica gel insole is in contact with the foot of the patient, so that the comfort is better, and the pain of the patient is relieved. The detachable design is adopted between the macromolecule water-absorbing fiber insole and the medical silica gel insole, the macromolecule water-absorbing fiber insole can be independently detached after seepage adsorption is saturated, the medical silica gel insole can be repeatedly used after being cleaned and aired, and the long-term use cost is reduced.

The invention provides an effect of a sugar foot health cream in promoting wound healing of sugar foot ulcer, relates to the technical field of traditional Chinese medicine components, and is technically characterized in that the sugar foot health cream is used for promoting wound healing of sugar foot ulcer and comprises the following traditional Chinese medicine components: rhizoma atractylodis, cortex phellodendri, semen coicis, cortex cinnamomi, radix angelicae sinensis, radix astragali and borneol. According to the application, a rat lower limb ischemic type 1 DFU model is constructed, and the model verifies that the Gangsukang ointment provided by the application is suitable for various DFU dialectical types; and by improving the dosage form, the preparation can be directly applied to the wound surface, so that the curative effect is improved, the stimulation to the wound surface is reduced, and the compliance of a patient is enhanced. Cream is a multi-component traditional Chinese medicine and can improve the anti-inflammatory effect; wound tissue regeneration is promoted; the ulcer surface healing is accelerated.

The invention provides a preparation method of loropetalum chinense extract and application of the loropetalum chinense extract in preparation of products for diabetic ulcer, and relates to the technical field of traditional Chinese medicine extraction. The preparation method comprises the following steps: mixing a loropetalum chinense raw material, water and coriolus hirsutus, and carrying out enzymolysis to obtain an enzymolysis product; mixing the enzymolysis product with 80wt%-90wt% of an ethanol solution, and performing ultrasonic-assisted extraction to obtain a component 1; adsorbing the component 1 through macroporous adsorption resin, washing the resin with methanol, then eluting with an elution phase, collecting 10-30 min eluent, combining and drying to obtain the component 1; the elution phase is a mixture of methanol and propylene glycol. The loropetalum chinense extract is prepared through a specific preparation method, and the diabetic foot ulcer treatment effect of the loropetalum chinense extract is remarkably improved.

The invention discloses a targeting stem cell exosome composition and application thereof in treating diabetic foot ulcer. According to the composition, a mesenchymal stem cell exosome is modified through genetic engineering, specific targeting fusion polypeptide is expressed on the surface of the mesenchymal stem cell exosome, anti-inflammatory miR-146a and a pro-angiogenic factor VEGF are loaded, and then the mesenchymal stem cell exosome is compounded with temperature-sensitive hyaluronic acid hydrogel to form a sustained release system. The sequence of the fusion polypeptide is as shown in SEQ ID NO: 1, and the targeting of exosomes to diabetic inflammation parts is remarkably improved; the stability of miR-146a is enhanced through chemical modification, and the miR-146a cooperates with VEGF to inhibit inflammation and promote revascularization. In-vitro experiments show that the composition reduces the levels of TNF-alpha and IL-6 by 85% and 88% respectively, and the cell migration rate reaches 99.3%; in-vivo experiments show that the wound healing rate of diabetic rats reaches 99.6% on the 14th day, and the collagen deposition area proportion is increased to 77.5%. The invention has targeting property, function synergy and slow release performance, and provides an efficient treatment strategy for diabetic foot ulcer.