62 results about "Foot ulcer" patented technology

A warming system, mounted to the foot of a bed, warms a person's lower extremities by directing air into the space between the mattress and overlaying blankets. A blower directs air into an elongated distribution chamber having many tiny exit apertures. The chamber is mounted at the foot of the bed, so that air exiting the apertures warms the person's feet. For maximum thermal transfer, the chamber is placed under the sheet and any blankets, but above the mattress cover and fitted sheet. The chamber may be implemented by a length of open cell foam, a hollow manifold with many punctures or other tiny distribution apertures, collapsible pocket, etc. While the person is lying on the bed beneath the blankets, with feet proximate the foot of the bed, the blower directs temperature-regulated air into the chamber and through the exit apertures, thereby warming the person's feet. A temperature regulator ensures a normothermic air temperature (or alternatively, hyperthermic air temperature.) Thus, the invention helps relieve or prevent "cold feet" by directing normothermic air at a person's lower extremities. Additionally, by applying heat to the feet and legs, the invention encourages blood flow by virtue of sympathetic vasodilation and local temperature-mediated vasodilation. The invention is also believed to prevent some leg and foot ulcers from forming by maintaining the lower extremity at a near normal temperature during sleep.

The present invention describes novel methods for using 9-deoxy-2′,9-α-methano-3-oxa-4,5,6-trinor-3,7-(1′,3′-interphenylene)-13,14-dihydro-prostaglandin F₁ (also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of foot ulcers in subjects with diabetic neuropathy. The invention also relates to kits for treatment and/or prevention of foot ulcers, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

The invention provides an MG53 (mitsugumin53) mutant and a preparation method thereof. The mutant is a serine-site mutant of MG53 protein in a Coiled-coil structural domain, and the mutant results in inactivation of MG53 phosphorylation. Meanwhile, the MG53 protein mutant can be used for preventing or treating diseases related to cellular membrane damage, such as diseases related to myocardial cell injury, diseases related to ulcer, trauma with a wound, particularly a difficult-to-heal wound, intestinal leakage, kidney injury and the like. The diseases related to myocardial cell injury can include one or more diseases related to following symptoms: myocardial ischemia, heart ischemia, heart ischemia/reperfusion injury, myocardial infarction, cardiac failure, arrhythmia and cardiac rupture. The diseases related to ulcer include one or more of following diseases: chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. Besides, the invention further provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing MG53 or MG53 mutant as well as preparation methods of the preparations.

The invention belongs to the technical field of new indications of drugs, and particularly discloses an application of externally used skin generation oil in preparation of drugs for preventing or treating diabetic peripheral circulation disturbance and foot ulcer. The externally used skin generation oil can effectively improve low temperature at soles due to peripheral circulation disturbance in early stage of diabetic foot ulcer, recover the sole pain threshold to a normal level, accelerate diabetic foot ulcer wound repair and shorten the wound repair time. The area of a foot ulcer wound surface of a diabetic rat is reduced to (4.0 plus or minus 0.1 mm<2>) from (51.3 plus or minus 3.5 mm<2>) after treated with the skin generation oil for 35 days, the wound surface heals basically, the skin is red and dry, and the skin surface is smooth; HE (hematoxylin-eosin) dyeing results show that the skin tissue structures of the foot wound surfaces of rats in an externally used skin generation oil group and an externally used skin generation oil and metformin group is relatively complete, collagen fibers at the wound edge are arranged in order, and inflammatory cell infiltration of wound surface tissue is reduced obviously.

This invention relates to methods of treating or preventing type 2 diabetes, diabetic neuropathy, diabetic cardiomyopathy, cataracts, diabetic retinopathy, foot ulcers, diabetic microangiopathy, diabetic macroangiopathy, diabetic ischemia reperfusion injury, diabetic cardiac ischemia reperfusion injury and/or insulin resistance syndrome (IRS) in mammals, particularly in humans, by administering a sodium-hydrogen exchanger type 1 (NHE-1) inhibitor or a pharmaceutical composition containing such an inhibitor. This invention also relates to combinations comprising NHE-1 inhibitors and a second pharmaceutical agent, said combinations being useful in treating type 2 diabetes, IRS, diabetic neuropathy, diabetic cardiomyopathy, cataracts, diabetic retinopathy, foot ulcers, diabetic ischemia reperfusion injury, diabetic cardiac ischemia reperfusion injury, diabetic microangiopathy and/or diabetic macroangiopathy.

The invention relates to a medicament for treating diabetic foot and deep ulcer. A conventional treatment method of the diabetic foot has certain curative effect at the moment, but causes long-term unhealing of foot ulcer due to foot paralysis, thus having poor effect. The medicament is prepared in the following steps: crushing naphthalene, borneol, pseudo-ginseng, musk and zinc oxide into fine powder in a proportion, and mixing. According to the medicament, harmful bacteria in deep focus can be killed in a short time, so that the root that various stubborn ulcers are hard to completely heal can be solved. The medicament is a medicament for treating diabetic food and deep ulcer with simple drugs, low cost and good curative effect.

The invention discloses new purpose of a human Keratiocyte growth factor 1 applied to treatment of foot ulcers and leg ulcers of diabetes. In the invention, the biological activity of proliferation of epithelial cells is promoted by using the specificity of the human Keratiocyte growth factor 1 to repair the damage of the epithelial, and the structural restoration of the foot ulcers and leg ulcers of diabetes promoted to achieve the treatment of the foot ulcers and leg ulcers of diabetes.

The invention discloses shoe customizing equipment suitable for a diabetic patient and a customizing method of the shoe customizing equipment. According to the technical scheme, the shoe customizing equipment suitable for the diabetic patient is characterized by comprising detection equipment and display equipment used for displaying the detection equipment, and the display equipment is in wireless communication connection with the detection equipment; a pressure sensing flat plate, an arc-shaped rail arranged above the pressure sensing flat plate and a camera arranged above the arc-shaped rail are arranged on the detection equipment, the camera can move along the arc-shaped rail, an opening is formed in the arc-shaped rail, a support used for supporting shanks is arranged at the opening,and an arc-shaped rod is arranged on the support. The shoe can provide extra depth and width, reduce foot friction, relieve foot pressure of a patient and correct the stress condition of the foot of the patient, so that the foot ulcer risk of each diabetic patient can be reduced by 80% or above, and great benefits can be brought to each diabetic patient.

The invention discloses a medical hydrogel non-porous moisture permeable film for wound healing. The medical hydrogel non-porous moisture permeable film comprises hydrogel (GelMA-g-NIPAAm) formed by methacrylic acid esterified gelatin-g-N-isopropyl acrylamide, copper-based MOF particles which are embedded into the hydrogel and form functionalized medical hydrogel with the hydrogel, and a non-porous vapor permeable barrier film or a film laminate prepared from a thermoplastic resin composition, wherein the surface of the non-porous vapor permeable barrier film or the film laminate is modified and connected to the medical hydrogel or the surface of the medical hydrogel. The medical hydrogel non-porous moisture permeable film has the advantages of high antibacterial property, good waterproofand vapor permeable properties, no adhesion and the like, and is suitable for common wounds, large-area burns, diabetic hand-foot ulcers and other difficult-to-heal wounds.

The invention discloses a foamed emulsion for protecting the skin of foot of diabetes patients. The foamed emulsion is prepared from purified water, urea, glycerin, glyceride, coconut oil foaming agent, Anhui safflower extract, and sea cucumber extract, and is prepared by the following steps: mixing all raw materials mentioned above according to a certain ratio, stirring for 2 to 3 hours in a sterile environment at a temperature of 54 to 56 DEG C, and finally filling the mixed foamed emulsion into bottles. The traditional Chinese medicine and sea biological product are organically compounded; other components are added, so the foamed emulsion can effectively and conveniently protect the skin of foot of diabetes patients, kill bacteria and moulds on the foot, maintain the water of foot, and improve the blood circulation of skin, and thus the foot ulcer caused by diabetes is effectively reduced or even avoided.

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for diabetic foot ulcer, which is prepared from the following raw materials in parts by weight: 12 to 14 parts of catechu, 10 to 15 parts of honeysuckle flower, 8 to 10 parts of rhizoma coptidis, 5 to 9 parts of herba taraxaci, 6 to 10 parts of herba portulacae, 1to 3 parts of hydrargyri oxydum rubrum, 5 to 7 parts of radix scutellariae, 8 to 10 parts of fructus crataegi, 5 to 7 parts of frankincense and 5 to 9 parts of ginger. The traditional Chinese medicine composition obtained by the invention is used for treating foot ulcer caused by diabetes mellitus, and can effectively relieve foot ulcer and effectively prevent diabetic foot ulcer after being smeared on affected parts of feet of a patient.

The invention relates to a toe cover for preventing and treating foot ulcers, comprising an internal cylinder body (1), an external cylinder body (2) and artificial cotton and medicaments (3). The external cylinder body (2) is arranged outside the internal cylinder body (1); the artificial cotton and the medicaments (3) are filled between the internal cylinder body (1) and the external cylinder body (2); and the medicaments comprises the following components: 0.1 to 0.2 gram of sulfur, 0.1 to 0.2 gram of lightyellow sophora root and 0.1 to 0.2 gram of humifuse euphorbia herb. With respect to the materials, the internal cylinder body and the external cylinder body are made of cloth with air permeability, moisture absorption property and elasticity. For the complete set of technology, the design is artful, two technologies are organically combined and mutually promoted so as to hit the pathogenesis, and the treatment principle of combining treatment and nourishment, including dampness elimination, itch relief and sterilization, is fully embodied.

The invention discloses a traditional Chinese medicine for treating trauma and diabetes foot ulcer and a preparation method. The medicine comprises the following raw materials in parts by mass: 1-2.5 parts of rhizoma paridis, 0.8-1.5 parts of rhizoma paridis, 0.5-1 part of rhizoma arisaematis, 0.5-2 parts of rhizoma kaempferiae, and 0.5-1 part of lithospermum. The preparation method comprises the following steps of mixing the raw materials and then grinding to 100-180 meshes, and sterilizing to obtain powder. The medicine has the functions of promoting and adjusting the circulation of qi and blood of the meridian, fighting against bacterium and diminishing inflammation, stopping bleeding and dissipating blood stasis, promoting qi and relieving pain, and clearing away heat and toxic materials, is dramatic in the effect of regenerating tissue to heal wound, rapid in wound healing, and wide in adaptation diseases, and is especially applicable to the treatment of diabetes foot ulcer, with little acne signs or scars left.

The invention concerns novel pharmaceutical compositions comprising 2, 4, 4′-trichloro-2′-hydroxydiphenylether (triclosan) and a thickener for use in the treatment of chronic wounds, in particular, in treatment of diabetic chronic wounds, such as foot ulcers.

The invention relates to the field of medicine and biotechnology, and particularly relates to application of a medicine. Milrinone is used for preparing the medicine for treating or improving diabetic foot ulcer or diabetic foot ulcer combined with heart failure. The invention provides the new application of the milrinone for preparing the medicine, and provides a new thinking and a method for preparing the medicine for treating the diabetic foot ulcer or diabetes combined with heart failure. The milrinone can effectively improve the therapeutic effect of diabetic foot ulcer and the quality of life of a patient, and provides a basis for clinical treatment for treating and intensifying heart failure and promoting foot ulcer healing.