25 results about "Foot ulcer" patented technology

The invention provides a foot ulcer risk screening instrument based on artificial intelligence, and relates to the field of foot ulcer risk screening instruments. The foot ulcer risk screening instrument based on artificial intelligence comprises a foot screening instrument, three vertical grooves are formed in each of the two sides of the front end of the foot screening instrument, three threaded rotating rods are arranged at the front ends of the inner walls of the vertical grooves, sliding blocks are arranged on the inner walls of the vertical grooves in a sliding mode, and connecting blocks are arranged at the rear ends of the sliding blocks. Limiting plates are arranged on the two sides of the rear ends of the connecting blocks in the middles of the two sides, limiting side plates are arranged on the two sides of the rear ends of the two sides of the connecting blocks on the two sides, and a detection side plate is arranged between every two adjacent limiting side plates. According to the invention, reasonable layout of foot dorsum, foot side and sole detection components is realized, three types of screening cameras are respectively corresponding to different areas of the foot, a structural basis is provided for comprehensive screening of multiple parts, and the problem of insufficient coverage of non-sole areas in traditional screening is effectively avoided.

The invention relates to the field of rehabilitation medical treatment, in particular to exercise rehabilitation auxiliary wearable equipment suitable for diabetics and obese patients, which comprises a single chip microcomputer and a plantar pressure adjusting assembly, the plantar pressure adjusting assembly comprises an insole, a plurality of openings are formed in the insole, and a plurality of elastic membranes used for sealing the openings are fixedly connected to the top of the insole; the insole is provided with a sensing assembly used for monitoring plantar pressure, and the sensing assembly is located below the elastic membrane and is in signal connection with the single-chip microcomputer. The bottom of the insole is fixedly connected with a substrate layer, a plurality of air cavities are formed in the substrate layer, and the air cavities are communicated with the adjacent openings; folding assemblies used for enhancing the supporting rigidity of the elastic membranes are arranged in the air cavities. By collecting plantar pressure data and regulating and controlling the supporting rigidity of the elastic membrane and the folding assembly, dynamic adaptation of the plantar supporting rigidity is achieved, the risks of foot ulcers of diabetic patients and plantar strain of obese patients are reduced, and comfort and safety in the exercise rehabilitation process are improved.

The invention discloses a traditional Chinese medicine composition for treating long-term ulceration of trauma and a preparation method thereof, and relates to the technical field of traditional Chinese medicine, and the composition is prepared by compatibility of four medicinal materials including hairyvein agrimony charcoal, dragon bone calcined powder, scorched licorice powder and indigo naturalis powder through a special processing technology. The preparation method adopts a step-by-step temperature control calcining method and an equivalent incremental mixing method, so that stable release of pharmacodynamic substances is ensured. Clinical research shows that the composition can reduce the exudation of a traumatic exudate wound within 7 days by 83%, shorten the healing period of diabetic foot ulcer by 40%, and realize the synergistic effect of antibiosis and tissue regeneration by adjusting the pH value of a wound microenvironment. A quality control system covers 12 core indexes such as tannin and calcium ions, the accuracy is improved by more than 3 times compared with that of a traditional preparation, and a safe and effective traditional Chinese medicine solution is provided for refractory wounds.

This invention discloses a strain of Codonopsis pilosula endophytic fungus that produces extracellular polysaccharides and its applications. This Codonopsis pilosula endophytic fungus is a short-spore bacterium, named... Brevibacillus schisleri CpRG-1. The Codonopsis pilosula endophytic bacteria of the present invention exhibit excellent ability to produce extracellular polysaccharides, producing high concentrations of extracellular polysaccharides, which can greatly reduce the cost of extracting polysaccharides from the medicinal herb Codonopsis pilosula; at the same time, the extracellular polysaccharides produced by the Codonopsis pilosula endophytic bacteria not only have antibacterial and hypoglycemic activities, but also can promote the healing of diabetic foot ulcers and improve the intestinal microbiota, providing new ideas for the development of antibacterial drugs, diabetes prevention foods and drugs, and diabetic foot ulcer treatment foods and drugs.

The invention relates to the field of medical treatment and health, and discloses a diabetic foot ulcer electrical stimulation and medicine synergistic treatment device and a using method, the diabetic foot ulcer electrical stimulation and medicine synergistic treatment device comprises a flexible main body belt, the two sides of the flexible main body belt are both provided with binding belts, the surface of the left binding belt is provided with a hook face hook-and-loop fastener, and the surface of the right binding belt is provided with a suede face hook-and-loop fastener; and the electrical stimulation drug delivery synergistic structure is used for integrating electrical stimulation and transdermal drug delivery, so that the rehabilitation treatment of the foot ulcer is enhanced. Organic fusion of treatment means is achieved through an electrical stimulation drug delivery synergistic structure, and the limitation of single treatment is broken through: a platinum composite flexible electrode and a gold composite flexible electrode are matched with an electrical stimulation control module, wound surface microcirculation can be improved through low-frequency electrical stimulation, and meanwhile, a blood vessel dilating agent stored in a drug storage chamber can further enhance the microcirculation improvement effect; the anti-inflammatory drug can reduce local inflammatory response possibly caused by electrical stimulation, and the synergistic effect of stimulation synergy and drug side effect reduction is achieved.

The utility model discloses a leprosy patient foot ulcer seepage adsorption insole which comprises a macromolecule water absorption fiber insole body, a medical silica gel insole body is detachably arranged on the macromolecule water absorption fiber insole body, a plurality of seepage flow guide holes are formed in the medical silica gel insole body, and the seepage flow guide holes penetrate through the medical silica gel insole body. The insole has the advantages that wound exudate of a patient flows into the macromolecule water-absorbing fiber insole on the lower layer through the exudate flow guide holes, liquid retention on the surface of the insole is reduced, the wound is kept dry, and comfort is better. The medical silica gel insole is in contact with the foot of the patient, so that the comfort is better, and the pain of the patient is relieved. The detachable design is adopted between the macromolecule water-absorbing fiber insole and the medical silica gel insole, the macromolecule water-absorbing fiber insole can be independently detached after seepage adsorption is saturated, the medical silica gel insole can be repeatedly used after being cleaned and aired, and the long-term use cost is reduced.

The invention provides a preparation method of loropetalum chinense extract and application of the loropetalum chinense extract in preparation of products for diabetic ulcer, and relates to the technical field of traditional Chinese medicine extraction. The preparation method comprises the following steps: mixing a loropetalum chinense raw material, water and coriolus hirsutus, and carrying out enzymolysis to obtain an enzymolysis product; mixing the enzymolysis product with 80wt%-90wt% of an ethanol solution, and performing ultrasonic-assisted extraction to obtain a component 1; adsorbing the component 1 through macroporous adsorption resin, washing the resin with methanol, then eluting with an elution phase, collecting 10-30 min eluent, combining and drying to obtain the component 1; the elution phase is a mixture of methanol and propylene glycol. The loropetalum chinense extract is prepared through a specific preparation method, and the diabetic foot ulcer treatment effect of the loropetalum chinense extract is remarkably improved.

This invention provides the application of exercise-induced sweat extract from healthy individuals in the preparation of a topical medication for diabetic foot ulcers, belonging to the field of biomedicine. Addressing the problems of high cost and limited efficacy of existing treatments, this invention creatively proposes to collect, wash, centrifuge, and filter sweat from healthy individuals induced by specific moderate-intensity aerobic exercise to prepare a sterile extract, which can be used as an active ingredient for topical treatment of diabetic foot ulcers. This sweat extract is rich in various bioactive components. In vitro transcriptomic analysis shows that it can reverse the abnormal gene expression profile associated with diabetic foot ulcers. In vivo animal experiments have confirmed that its topical application can significantly accelerate the healing of diabetic wounds through multi-target synergistic effects of anti-inflammation, angiogenesis, epithelialization, and collagen deposition, with effects comparable to recombinant growth factors. This invention provides a novel treatment strategy that is natural, safe, low-cost, and highly effective, with broad clinical application prospects.

The invention relates to the field of diabetic foot ulcer, and discloses a diabetic foot ulcer wound edge skin-derived extracellular vesicle as well as a preparation method and application thereof. The preparation method comprises the following steps: pretreating diabetic foot ulcer wound edge skin tissues to obtain tissue fragments; the method comprises the following steps: mixing type IV collagenase and DNaseI enzyme in a DMEM (Dulbecco Modified Eagle Medium) high-glucose culture medium to prepare a tissue dissociation solution; carrying out primary dissociation by using pancreatin digestive juice, and then carrying out secondary dissociation by using tissue dissociation liquid; sequentially and alternately carrying out gradient size filtration and differential centrifugation on the filtrate, and collecting supernate; performing ultra-high-speed centrifugation, ultra-filtration and gradient needle type filtration on the supernate; and performing ultra-high-speed centrifugation again to obtain the diabetic foot ulcer wound edge skin-derived extracellular vesicles. The concentration of the obtained EVs is 3.29 mg / mL, and the characteristics of delayed healing and insufficient collagen deposition can be stably obtained by injecting the EVs into normal mice.

Nanoparticle-Based Smart Dressing for Real-Time Healing of Chronic Diabetic Foot Ulcers

The application discloses a novel brown algae polysaccharide SARP for promoting healing of diabetic ulcers and a preparation and application thereof. A novel SARP is obtained through Sephacryl S-300 / HR gel column separation and purification, and the molecular weight of the SARP is about 45.4 kDa, which is composed of mannuronic acid (76.56%), guluronic acid (18.89%) and a small amount of glucuronic acid (4.55%). Compared with alginate separated from other brown algae, the SARP has a higher content of mannuronic acid. The SARP shows a better in-vitro antioxidant capacity, and can obviously reverse the cell damage of HUVECs caused by H2O2 and high sugar in the HUVECs. In addition, the SARP can promote the migration and tubular formation of the HUVECs. In-vivo experiments further show that the SARP can promote the healing of diabetic ulcer in rats, and can reduce the oxidative stress, inflammation level and lipid disorder in the rats. The SARP has a simple purification route, can be prepared in a large amount, and is a very promising novel drug for treating diabetic foot ulcers.

The present invention relates to a mechanical wound cleansing device comprising a carrier layer and an abrasive loop system arranged above the carrier layer, whereby the loop system is an intermeshed fiber system which is intermeshed above the carrier layer and / or a loop system comprising highly and softly abrasive loops. The present invention further relates to a method of producing said mechanical wound cleansing device. The present invention finally relates to the use of said wound cleansing device for the abrasive removal of and cleansing of wounds, especially for venous leg ulcers, diabetic foot ulcers (neuropathic and neuro-ischemic), arterial ulcers, mixed etiology ulcers, pressure ulcers or traumatic wounds.

The invention discloses a traditional Chinese medicine formula for treating diabetic foot and bedsore, and relates to the technical field of traditional Chinese medicine external preparations, the traditional Chinese medicine formula comprises the following medicinal materials in parts by weight: nidus vespae, carbonized hair, coptis chinensis, golden cypress, scutellaria baicalensis, rheum officinale, centipede, scorpion and the like, the components have a synergistic effect under a preferable ratio, and the formula is 80-120-mesh external powder. The traditional Chinese medicine composition is prepared through independent crushing, three-dimensional mixing and other processes, can be used for preparing external medicines for diabetic foot ulcer and bedsore, and can achieve integrated treatment of counteracting toxic substances and removing decay, dispersing blood stasis and promoting tissue regeneration, and astringing sores and closing up.

The present application relates to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating diabetic foot and a preparation method thereof.The traditional Chinese medicine composition is made of the following weight parts of traditional Chinese medicine raw materials: 180-220 parts of raw astragalus, 140-160 parts of angelica, 90-120 parts of dogwood, 180-220 parts of coptis, 180-220 parts of scrophulariaceae, 90-120 parts of atractylodes, 90-120 parts of cortex phellodendri, 40-60 parts of white yam, 40-60 parts of pearl powder, 40-60 parts of geum japonicum and 4-8 parts of artificial musk.The traditional Chinese medicine composition has the effects of benefiting qi and nourishing blood, nourishing yin and purging fire, clearing heat and drying dampness, promoting blood circulation and generating muscle, and has a good therapeutic effect on foot ulcer caused by diabetes.Moreover, the traditional Chinese medicine composition is safe and effective for long-term use, and the patient is not prone to recurrence.

The invention provides application of arbutin in preparation of a medicine for promoting wound healing of diabetic foot ulcer, and relates to the technical field of biomedicine, in the application, through animal experiments and cell experiments, the treatment effect of external-use arbutin cream on diabetic foot ulcer healing is systematically evaluated, and the action mechanism of the external-use arbutin cream is explored. In the research, a diabetic foot ulcer rat model is constructed, drug administration treatment is carried out in groups, meanwhile, related experiments are carried out on human prepuce fibroblasts, and through multiple detection methods and statistical analysis, it is proved that the arbutin cream plays a positive role in promoting wound healing, granulation tissue formation, collagen deposition, fibroblast migration and the like.

The invention discloses a treatment-sensing integrated insole for diabetic foot ulcer and a preparation method of the treatment-sensing integrated insole, and belongs to the technical field of functional materials. The treatment-sensing integrated insole for the diabetic foot ulcer comprises an insole base body and a nitrogen-doped carbon sponge embedded in the insole base body, the insole base body is hydrogel containing natural antibacterial substances; the nitrogen-doped carbon sponge is connected with a wire, and the wire is connected with an external friction power generation device and / or a signal transmission device. According to the treatment-sensing integrated insole for diabetic foot ulcer, the major defect of diabetic foot ulcer wound nursing is overcome, the sensing function and the treatment function are organically combined in one system, prevention and rehabilitation can be truly integrated, and the nursing pressure of the foot ulcer is relieved.

The invention discloses a clinical sampling and detecting device for endocrine diabetic foot, and relates to the field of sampling and detecting equipment. According to the clinical sampling and detecting device for the endocrine diabetic foot, by arranging the bottom plate and the cover shell, in the sampling and detecting process of the sick foot of a patient, after the cover shell is rotated to cover the foot of the patient, a draught fan is started to achieve air flow circulation in the cover shell, air in the cover shell is circulated into an absorption cavity through air flow, and the air is absorbed by a filtering absorption plate; the treatment cavity is merged into an air flow loop after the examination personnel completes the examination operation, ozone gas is introduced into the air flow loop through an air inlet hole, and the ozone gas is in contact with foot ulcer of the patient in the air flow circulation process, so that disinfection and adjuvant treatment of the foot ulcer of the patient are realized, and recovery of the foot of the patient is facilitated; after ozone circulates for a period of time, the absorption cavity is merged into an airflow loop, redundant ozone is absorbed through the filtering absorption plate, and the device can effectively protect patients and examination personnel in the whole process before and after examination.

The utility model relates to the field of medical instruments, in particular to an electrode fixing device of EIT monitoring equipment. According to the electrode fixing device of the EIT monitoring equipment, the electrode contact can be moved to monitor foot ulcers of patients, the electrode fixing device is suitable for patients with different foot shapes and sizes, early monitoring and timely treatment are facilitated, the monitoring efficiency and effect are improved, and use is flexible and convenient. An electrode fixing device of EIT monitoring equipment comprises a detection table, limiting protection plates and the like, and the upper side of the right portion of the detection table is connected with the front limiting protection plate and the rear limiting protection plate. According to the foot ulcer monitoring device, the electrode contact moves to be in contact with the foot of a patient through movement of the mounting plate, then the electrode column moves to be in contact with the conductive column to be electrified, and the electrode contact discharges for monitoring, so that the electrode contact can be moved to monitor foot ulcer of the patient, and the foot ulcer monitoring device is suitable for patients with different foot shapes and sizes; early monitoring and timely treatment are facilitated, the monitoring efficiency and effect are improved, and use is flexible and convenient.

The invention relates to the technical field of biological medicine, and particularly discloses MaR1 nano-particles as well as a preparation method and application thereof, and the MaR1 nano-particles are obtained by loading Maresin-1 into a polylactic acid nano-carrier. The MaR1 nano-particles are of a spherical structure, and the particle size ranges from 195 nm to 215 nm. The MaR1 nano-particles provided by the invention are beneficial to promoting the healing of diabetic wounds, inhibiting the formation of pathological scars and accelerating the regeneration and reconstruction of epidermis structures, so that the diabetic foot ulcer is treated.

This invention discloses a microneedle system, its preparation method, and its applications. The microneedle system includes a microneedle substrate and a microneedle tip. The microneedle substrate is a cross-linked polyvinyl alcohol hydrogel, and the microneedle tip includes the cross-linked polyvinyl alcohol hydrogel and FGF21 and GLP-1RA encapsulated within the cross-linked polyvinyl alcohol hydrogel. This invention prepares PVA with localized ROS responsiveness. tsPBA The microneedle system co-encapsulates FGF21 and GLP-1RA, enabling them to work synergistically at the wound site to improve endothelial function, promote angiogenesis, and facilitate keratinocyte migration, thereby achieving highly effective treatment of diabetic foot ulcers.

This embodiment provides a method and system for assessing the risk of diabetic foot ulcers based on visual nerves. The method includes: acquiring phosphorescent images of the patient's foot ulcer, images of the ulcer wound, and sensor feature data; processing the phosphorescent images based on a phosphorescent sub-network model to obtain an oxygen-phosphorescence response feature vector; processing the ulcer wound images based on a wound sub-network model to obtain an ulcer pathological feature vector; extracting physiological parameters from the sensor feature data based on a sensor sub-network model to obtain a physiological feature vector; and weightedly concatenating and fusing the oxygen-phosphorescence response feature vector, ulcer pathological feature vector, and physiological feature vector based on a fusion sub-network model to obtain a fused feature vector. The fused feature vector is then used for recognition operations to obtain a recognition result, the value of which indicates the patient's foot ulcer risk assessment level. This application achieves effective and accurate assessment of the condition of foot ulcer wounds in diabetic patients.

This invention relates to the field of flexible bioelectronics and skin-attached phototherapy technology, and discloses a temperature and pressure sensing flexible phototherapy patch and system for diabetic foot ulcers, including a flexible phototherapy patch, a control module, and a power supply module. The flexible phototherapy patch includes an adhesion layer, a pressure sensing layer, a light-emitting layer, a temperature sensing unit, a protective covering layer, and a flexible interface. The pressure sensing layer has a pressure sensing area and a light-transmitting area. The light-emitting layer is disposed at or corresponding to the light-transmitting area, allowing emitted red and near-infrared light to pass through the protective covering layer and irradiate the corresponding area of ​​the diabetic foot ulcer. The temperature sensing unit is disposed near the light-emitting layer to monitor local temperature rise. The control module receives pressure and temperature signals and adjusts the phototherapy output parameters according to the pressure signal, reducing the luminous power or stopping luminescence when the temperature exceeds a preset threshold. This invention combines skin-attached temperature and pressure monitoring, dual-band phototherapy output, and automatic over-temperature protection, making it suitable for continuous management and auxiliary phototherapy of diabetic foot ulcers.

This invention discloses a pneumatic protective device for diabetic foot ulcers, comprising a shoe body (1), an outer box (2) located at the heel of the shoe body (1), an air pump control unit located inside the outer box (2), and a bottom box (3) located at the heel of the shoe body (1), containing a main control board module; the shoe body (1) contains a pneumatic positive pressure protection unit and a pneumatic negative pressure protection unit. The method of use is as follows: when the patient's posterior tibial artery and dorsalis pedis artery have poor blood supply and the temperature of the entire sole is below a set threshold, the pneumatic positive pressure protection unit is selected for positive pressure protection; when the patient's entire foot has poor blood supply and a low metabolic level, the pneumatic negative pressure protection unit is selected for negative pressure protection. This invention has the characteristic of providing precise pneumatic protection based on the condition of the diabetic patient's foot ulcer.

The invention relates to a diabetic foot ulcer risk assessment method and system, and the method comprises the steps: obtaining medical image data, clinical data and biomechanical data, inputting a trained risk assessment model, and outputting a foot ulcer risk result; the risk assessment model comprises an input layer used for inputting medical image data, clinical data and biomechanical data; the feature extraction layer is used for extracting medical image features, clinical data features and biomechanical features according to the medical image data, the clinical data and the biomechanical data; the feature fusion layer is used for obtaining fusion features according to the medical image features and the clinical data features; according to the fusion features and the biomechanical features, multi-modal features are obtained; and the output layer is used for outputting a foot ulcer risk result according to the multi-modal characteristics. And a diabetic foot ulcer risk assessment scheme based on effective multi-modal feature fusion is provided.

A compound represented by formula (I) and a preparation method thereof, and a pharmaceutically acceptable salt thereof, a metabolic precursor thereof, a metabolite thereof, an isomer thereof or a prodrug thereof; experiments show that the indole alkaloid not only promotes axon growth of peripheral sensory neurons, improves the nerve conduction velocity and anesthesia symptom of diabetic rats, but also promotes healing of foot ulcer wounds of diabetic rats, thus having good therapeutic effects on diabetic complication peripheral neuropathy and diabetic feet; they also show that the indole alkaloid also obviously reduces a degree of pulmonary fibrosis induced by bleomycin in mice, and plays a role in protecting lung tissues.