64 results about "Foot ulcer" patented technology

The present invention provides orthotic devices for use in managing the treatment and prevention of lower extremity injuries, including foot ulcers. In various aspects, the present invention provides foot-worn orthotics which provide for improved compliance monitoring, and methods of their manufacture and use.

A warming system, mounted to the foot of a bed, warms a person's lower extremities by directing air into the space between the mattress and overlaying blankets. A blower directs air into an elongated distribution chamber having many tiny exit apertures. The chamber is mounted at the foot of the bed, so that air exiting the apertures warms the person's feet. For maximum thermal transfer, the chamber is placed under the sheet and any blankets, but above the mattress cover and fitted sheet. The chamber may be implemented by a length of open cell foam, a hollow manifold with many punctures or other tiny distribution apertures, collapsible pocket, etc. While the person is lying on the bed beneath the blankets, with feet proximate the foot of the bed, the blower directs temperature-regulated air into the chamber and through the exit apertures, thereby warming the person's feet. A temperature regulator ensures a normothermic air temperature (or alternatively, hyperthermic air temperature.) Thus, the invention helps relieve or prevent "cold feet" by directing normothermic air at a person's lower extremities. Additionally, by applying heat to the feet and legs, the invention encourages blood flow by virtue of sympathetic vasodilation and local temperature-mediated vasodilation. The invention is also believed to prevent some leg and foot ulcers from forming by maintaining the lower extremity at a near normal temperature during sleep.

The invention relates to an active wound repair material, specifically to a functional dressing and a preparation method and application thereof, belonging to the field of medical materials. To overcome a technical problem, the invention provides the functional dressing, which belongs to biologically active wound repair materials. The functional dressing is prepared from the following raw materials by weight: 2 to 6 parts of biologically active glass, 12 to 20 parts of alginate, 4 to 12 parts of chitosan and 100 to 200 parts of water. Multiple dosage forms can be prepared from the above-mentioned raw materials, mainly comprising a gel, a dressing, etc. The functional dressing provided by the invention has the advantages of bacteriostatic action on a wound, promotion of wound healing and growth, adsorption of a small amount of tissue exudates, good biosecurity, waterproof performance, a bacterium blocking effect, etc. The functional dressing has a wide application scope, is applicable to mechanical trauma and operative incision (wound) and exerts a good therapeutic effect on hard-healing wounds like burns and scalds, diabetic foot, ulcer and pressure sores and a good curative effect on an infectious wound and a delayed union wound.

The present invention describes novel methods for using 9-deoxy-2′,9-α-methano-3-oxa-4,5,6-trinor-3,7-(1′,3′-interphenylene)-13,14-dihydro-prostaglandin F1 (also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and / or prevention of foot ulcers in subjects with diabetic neuropathy. The invention also relates to kits for treatment and / or prevention of foot ulcers, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

An electrosurgical method for treating foot ulcer, including diabetic foot ulcer, comprising: positioning an active electrode in close proximity to the ulcer, the active electrode being disposed on a distal end of an electrosurgical shaft; applying a high-frequency voltage potential difference across the active electrode and a return electrode in the presence of an electrically conductive fluid, the voltage potential being sufficient to generate plasma at the active electrode; and stimulating the ulcer with the active electrode to increase blood flow, remove unhealthy tissue and induce the body's natural healing response.

A warming system, mounted to the foot of a bed, warms a person's lower extremities by directing air into the space between the mattress and overlaying blankets. A blower directs air into an elongated distribution chamber having many tiny exit apertures. The chamber is mounted at the foot of the bed, so that air exiting the apertures warms the person's feet. For maximum thermal transfer, the chamber is placed under the sheet and any blankets, but above the mattress cover and fitted sheet. The chamber may be implemented by a length of open cell foam, a hollow manifold with many punctures or other tiny distribution apertures, collapsible pocket, etc. While the person is lying on the bed beneath the blankets, with feet proximate the foot of the bed, the blower directs temperature-regulated air into the chamber and through the exit apertures, thereby warming the person's feet. A temperature regulator ensures a normothermic air temperature (or alternatively, hyperthermic air temperature.) Thus, the invention helps relieve or prevent “cold feet” by directing normothermic air at a person's lower extremities. Additionally, by applying heat to the feet and legs, the invention encourages blood flow by virtue of sympathetic vasodilation and local temperature-mediated vasodilation. The invention is also believed to prevent some leg and foot ulcers from forming by maintaining the lower extremity at a near normal temperature during sleep.

The present disclosure provides apparatuses and methods for measuring capacitance as an indication of susceptibility to the formation of a diabetic foot ulcer.

The invention provides an MG53 (mitsugumin53) mutant and a preparation method thereof. The mutant is a serine-site mutant of MG53 protein in a Coiled-coil structural domain, and the mutant results in inactivation of MG53 phosphorylation. Meanwhile, the MG53 protein mutant can be used for preventing or treating diseases related to cellular membrane damage, such as diseases related to myocardial cell injury, diseases related to ulcer, trauma with a wound, particularly a difficult-to-heal wound, intestinal leakage, kidney injury and the like. The diseases related to myocardial cell injury can include one or more diseases related to following symptoms: myocardial ischemia, heart ischemia, heart ischemia / reperfusion injury, myocardial infarction, cardiac failure, arrhythmia and cardiac rupture. The diseases related to ulcer include one or more of following diseases: chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. Besides, the invention further provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing MG53 or MG53 mutant as well as preparation methods of the preparations.

An electrosurgical method for treating foot ulcer, including diabetic foot ulcer, comprising: positioning an active electrode in close proximity to the ulcer, the active electrode being disposed on a distal end of an electrosurgical shaft; applying a high-frequency voltage potential difference across the active electrode and a return electrode in the presence of an electrically conductive fluid, the voltage potential being sufficient to generate plasma at the active electrode; and stimulating the ulcer with the active electrode to increase blood flow, remove unhealthy tissue and induce the body's natural healing response.

An electrosurgical method for treating foot ulcer, including diabetic foot ulcer, comprising: positioning an active electrode in close proximity to the ulcer, the active electrode being disposed on a distal end of an electrosurgical shaft; applying a high-frequency voltage potential difference across the active electrode and a return electrode in the presence of an electrically conductive fluid, the voltage potential being sufficient to generate plasma at the active electrode; and stimulating the ulcer with the active electrode to increase blood flow, remove unhealthy tissue and induce the body's natural healing response.

The invention belongs to the technical field of new indications of drugs, and particularly discloses an application of externally used skin generation oil in preparation of drugs for preventing or treating diabetic peripheral circulation disturbance and foot ulcer. The externally used skin generation oil can effectively improve low temperature at soles due to peripheral circulation disturbance in early stage of diabetic foot ulcer, recover the sole pain threshold to a normal level, accelerate diabetic foot ulcer wound repair and shorten the wound repair time. The area of a foot ulcer wound surface of a diabetic rat is reduced to (4.0 plus or minus 0.1 mm<2>) from (51.3 plus or minus 3.5 mm<2>) after treated with the skin generation oil for 35 days, the wound surface heals basically, the skin is red and dry, and the skin surface is smooth; HE (hematoxylin-eosin) dyeing results show that the skin tissue structures of the foot wound surfaces of rats in an externally used skin generation oil group and an externally used skin generation oil and metformin group is relatively complete, collagen fibers at the wound edge are arranged in order, and inflammatory cell infiltration of wound surface tissue is reduced obviously.

This invention relates to methods of treating or preventing type 2 diabetes, diabetic neuropathy, diabetic cardiomyopathy, cataracts, diabetic retinopathy, foot ulcers, diabetic microangiopathy, diabetic macroangiopathy, diabetic ischemia reperfusion injury, diabetic cardiac ischemia reperfusion injury and / or insulin resistance syndrome (IRS) in mammals, particularly in humans, by administering a sodium-hydrogen exchanger type 1 (NHE-1) inhibitor or a pharmaceutical composition containing such an inhibitor. This invention also relates to combinations comprising NHE-1 inhibitors and a second pharmaceutical agent, said combinations being useful in treating type 2 diabetes, IRS, diabetic neuropathy, diabetic cardiomyopathy, cataracts, diabetic retinopathy, foot ulcers, diabetic ischemia reperfusion injury, diabetic cardiac ischemia reperfusion injury, diabetic microangiopathy and / or diabetic macroangiopathy.

The invention relates to a medicament for treating diabetic foot and deep ulcer. A conventional treatment method of the diabetic foot has certain curative effect at the moment, but causes long-term unhealing of foot ulcer due to foot paralysis, thus having poor effect. The medicament is prepared in the following steps: crushing naphthalene, borneol, pseudo-ginseng, musk and zinc oxide into fine powder in a proportion, and mixing. According to the medicament, harmful bacteria in deep focus can be killed in a short time, so that the root that various stubborn ulcers are hard to completely heal can be solved. The medicament is a medicament for treating diabetic food and deep ulcer with simple drugs, low cost and good curative effect.

The invention relates to a composition of glycosaminoglycans for the treatment of diabetic foot ulcer, it specifically relates to low molecular weight heparins (LMWHs) and very low molecular weight heparins (VLMWHs) in the treatment of chronic ulcers, particularly of diabetic foot ulcers, and more specifically in the manufacture of a medicinal product for the treatment of chronic ulcers, and particularly diabetic foot ulcers and pressure ulcers.

The invention provides antibacterial hydrogel suitable for diabetic foot ulcer and a preparation method of the antibacterial hydrogel, and belongs to the technical field of preparation of medical hydrogel. The preparation method comprises the following steps: (1) adding acrylic acid, a cross-linking agent and an initiator solution into a sodium alginate solution, and carrying out sodium alginate modification; (2) adding a medicinal active component D and an antibacterial component E, and adding a CaCl2 solution to prepare a crude gel product; and (3) washing the coarse gel, and sucking the washed coarse gel with filter paper to obtain the antibacterial hydrogel. According to the prepared hydrogel, by improving sodium alginate, the wound exudate absorption speed can be greatly increased, the wound is treated in time, traditional Chinese medicine ingredients are added, the hydrogel permeates into the wound through slow release to be absorbed by a human body, the local medication effect is achieved, and the blood supply condition of the ulcer position can be improved through addition of the conyzasaponin R, so that the healing speed of the diabetic foot ulcer is increased through a synergistic effect.

The present invention describes novel methods for using 9-deoxy-2', 9-alpha-methano-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-13,14-dihydro-prostaglandin F1 (also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and / or prevention of foot ulcers in subjects with diabetic neurophathy. The invention also relates to kits for treatment and / or prevention of foot ulcers, comprising an effective amount of treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

The invention discloses new purpose of a human Keratiocyte growth factor 1 applied to treatment of foot ulcers and leg ulcers of diabetes. In the invention, the biological activity of proliferation of epithelial cells is promoted by using the specificity of the human Keratiocyte growth factor 1 to repair the damage of the epithelial, and the structural restoration of the foot ulcers and leg ulcers of diabetes promoted to achieve the treatment of the foot ulcers and leg ulcers of diabetes.

The invention discloses shoe customizing equipment suitable for a diabetic patient and a customizing method of the shoe customizing equipment. According to the technical scheme, the shoe customizing equipment suitable for the diabetic patient is characterized by comprising detection equipment and display equipment used for displaying the detection equipment, and the display equipment is in wireless communication connection with the detection equipment; a pressure sensing flat plate, an arc-shaped rail arranged above the pressure sensing flat plate and a camera arranged above the arc-shaped rail are arranged on the detection equipment, the camera can move along the arc-shaped rail, an opening is formed in the arc-shaped rail, a support used for supporting shanks is arranged at the opening,and an arc-shaped rod is arranged on the support. The shoe can provide extra depth and width, reduce foot friction, relieve foot pressure of a patient and correct the stress condition of the foot of the patient, so that the foot ulcer risk of each diabetic patient can be reduced by 80% or above, and great benefits can be brought to each diabetic patient.

The invention discloses a medical hydrogel non-porous moisture permeable film for wound healing. The medical hydrogel non-porous moisture permeable film comprises hydrogel (GelMA-g-NIPAAm) formed by methacrylic acid esterified gelatin-g-N-isopropyl acrylamide, copper-based MOF particles which are embedded into the hydrogel and form functionalized medical hydrogel with the hydrogel, and a non-porous vapor permeable barrier film or a film laminate prepared from a thermoplastic resin composition, wherein the surface of the non-porous vapor permeable barrier film or the film laminate is modified and connected to the medical hydrogel or the surface of the medical hydrogel. The medical hydrogel non-porous moisture permeable film has the advantages of high antibacterial property, good waterproofand vapor permeable properties, no adhesion and the like, and is suitable for common wounds, large-area burns, diabetic hand-foot ulcers and other difficult-to-heal wounds.

The invention discloses a foamed emulsion for protecting the skin of foot of diabetes patients. The foamed emulsion is prepared from purified water, urea, glycerin, glyceride, coconut oil foaming agent, Anhui safflower extract, and sea cucumber extract, and is prepared by the following steps: mixing all raw materials mentioned above according to a certain ratio, stirring for 2 to 3 hours in a sterile environment at a temperature of 54 to 56 DEG C, and finally filling the mixed foamed emulsion into bottles. The traditional Chinese medicine and sea biological product are organically compounded; other components are added, so the foamed emulsion can effectively and conveniently protect the skin of foot of diabetes patients, kill bacteria and moulds on the foot, maintain the water of foot, and improve the blood circulation of skin, and thus the foot ulcer caused by diabetes is effectively reduced or even avoided.

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for diabetic foot ulcer, which is prepared from the following raw materials in parts by weight: 12 to 14 parts of catechu, 10 to 15 parts of honeysuckle flower, 8 to 10 parts of rhizoma coptidis, 5 to 9 parts of herba taraxaci, 6 to 10 parts of herba portulacae, 1to 3 parts of hydrargyri oxydum rubrum, 5 to 7 parts of radix scutellariae, 8 to 10 parts of fructus crataegi, 5 to 7 parts of frankincense and 5 to 9 parts of ginger. The traditional Chinese medicine composition obtained by the invention is used for treating foot ulcer caused by diabetes mellitus, and can effectively relieve foot ulcer and effectively prevent diabetic foot ulcer after being smeared on affected parts of feet of a patient.

The invention discloses new medical uses of roxadustat, specifically applications in preparation of a pharmaceutical preparation for assisted treatment of diabetic foot. According to the present invention, the uses of roxadustat in the diabetic foot treating pharmaceutical preparation are firstly disclosed; and the clinical test research results show that the foot ulcers of diabetic foot patientscan be significantly treated, hyperlipidemia, hypertension, inflammation and other systemic symptoms can be improved, the recurrence rate can be reduced, and the life quality of patients is exactly improved after the diabetic foot patients are treated with roxadustat.

The invention relates to a toe cover for preventing and treating foot ulcers, comprising an internal cylinder body (1), an external cylinder body (2) and artificial cotton and medicaments (3). The external cylinder body (2) is arranged outside the internal cylinder body (1); the artificial cotton and the medicaments (3) are filled between the internal cylinder body (1) and the external cylinder body (2); and the medicaments comprises the following components: 0.1 to 0.2 gram of sulfur, 0.1 to 0.2 gram of lightyellow sophora root and 0.1 to 0.2 gram of humifuse euphorbia herb. With respect to the materials, the internal cylinder body and the external cylinder body are made of cloth with air permeability, moisture absorption property and elasticity. For the complete set of technology, the design is artful, two technologies are organically combined and mutually promoted so as to hit the pathogenesis, and the treatment principle of combining treatment and nourishment, including dampness elimination, itch relief and sterilization, is fully embodied.

The invention relates to pharmaceutical compositions and to methods for inducing angiogenesis in conditions associated with insufficient vascularization, e.g. ischemia and diabetic conditions, such as diabetic foot ulcers. In particular, pharmaceutical compositions comprising sustained release nanoparticles that contain 1K1 fragment of Hepatocyte Growth Factor / Scatter Factor are provided.

The invention discloses a traditional Chinese medicine for treating trauma and diabetes foot ulcer and a preparation method. The medicine comprises the following raw materials in parts by mass: 1-2.5 parts of rhizoma paridis, 0.8-1.5 parts of rhizoma paridis, 0.5-1 part of rhizoma arisaematis, 0.5-2 parts of rhizoma kaempferiae, and 0.5-1 part of lithospermum. The preparation method comprises the following steps of mixing the raw materials and then grinding to 100-180 meshes, and sterilizing to obtain powder. The medicine has the functions of promoting and adjusting the circulation of qi and blood of the meridian, fighting against bacterium and diminishing inflammation, stopping bleeding and dissipating blood stasis, promoting qi and relieving pain, and clearing away heat and toxic materials, is dramatic in the effect of regenerating tissue to heal wound, rapid in wound healing, and wide in adaptation diseases, and is especially applicable to the treatment of diabetes foot ulcer, with little acne signs or scars left.

The present disclosure is related to a method of managing diabetic foot ulcers (DFUs), pressure ulcers, venous leg ulcers and associated complications such as bacterial infection, gangrene, tissue necrosis, amputation, proximal limb loss and septicaemia. This method of managing is by administration of pharmaceutical composition comprising pentameric type A procyanidin, trimeric procyanidin and tetrameric procyanidin, optionally along with pharmaceutically acceptable excipient.

The invention concerns novel pharmaceutical compositions comprising 2, 4, 4′-trichloro-2′-hydroxydiphenylether (triclosan) and a thickener for use in the treatment of chronic wounds, in particular, in treatment of diabetic chronic wounds, such as foot ulcers.

The invention relates to the field of medicine and biotechnology, and particularly relates to application of a medicine. Milrinone is used for preparing the medicine for treating or improving diabetic foot ulcer or diabetic foot ulcer combined with heart failure. The invention provides the new application of the milrinone for preparing the medicine, and provides a new thinking and a method for preparing the medicine for treating the diabetic foot ulcer or diabetes combined with heart failure. The milrinone can effectively improve the therapeutic effect of diabetic foot ulcer and the quality of life of a patient, and provides a basis for clinical treatment for treating and intensifying heart failure and promoting foot ulcer healing.