42 results about "Foot ulcer" patented technology

The invention relates to the technical field of biomarkers, in particular to a biomarker composition for diabetic foot ulcer and application of the biomarker composition. The invention provides a biomarker combination for diabetic foot ulcer. The biomarker combination comprises a DDIT4 gene and a PKM gene. According to the invention, by integrating transcriptome sequencing data and single cell sequencing data, biomarkers DDIT4 and PKM closely related to diabetic foot ulcer (DFU) are successfully screened out. The expression of the two genes in a disease group is remarkably up-regulated, and the two genes are stably expressed in different data sets, so that a reliable molecular target is provided for early diagnosis of DFU.

The present application relates to the technical field of biological medicine, and particularly relates to a stem cell culture method for promoting wound healing and application thereof. The stem cell culture method for promoting wound healing comprises the following steps: step one, providing umbilical cord-derived mesenchymal stem cells; step two, adding luteolin and baicalin as culture medium additives in a serum-supplemented culture medium, wherein the concentration of luteolin is 1-10 micromoles / L, and the concentration of baicalin is 1-10 micromoles / L; step three, inoculating the mesenchymal stem cells into the culture medium containing the additives for culture, and the culture condition is 34-40 DEG C, 4-6% CO2, and the culture time is 48-96 hours; step four, harvesting the cultured mesenchymal stem cells to obtain stem cells for promoting wound healing. The culture method can promote the stem cells to secrete various growth factors, significantly improve the secretion of PGE2 and VEGF-C growth factors, and make the wound healing rate of the stem cell treatment group reach 96%, which has a significant effect on treating diabetic foot ulcers.

According to various embodiments, a server for predicting determination on a diabetic foot on the basis of a plurality of pieces of data on the basis of a prediction model, comprises: a communication interface; a memory; and a processor, wherein the processor is configured to: obtain at least one piece of image data and at least one piece of first sensing data from an external server of an external user through the communication interface; obtain first ulcer output data by inputting the at least one piece of image data and the at least one piece of first sensing data to the prediction model; when it is determined that the first ulcer output data exceeds a preset first threshold value on the basis of a result of comparing the first ulcer output data with the preset first threshold value, output that a foot ulcer of the external user is likely to be diabetic foot ulcer; when it is determined that the first ulcer output data exceeds a second threshold value set to be greater than the first threshold value on the basis of a result of comparing the first ulcer output data with the second threshold value, output that the foot ulcer of the external user is highly likely to be the diabetic foot ulcer; and transmit, through the communication interface, result data for the first ulcer output data determined to exceed the first threshold value and / or the second threshold value, and guideline data presenting at least one guideline on the basis of the result data, wherein the prediction model is trained on the basis of a plurality of pieces of image data, a plurality of pieces of first sensing data, and a plurality of pieces of second sensing data, which are obtained from a plurality of users, a plurality of pieces of result data output from the plurality of users, and at least one piece of professional opinion data obtained by observing the plurality of users.

The present invention is a diabetic healing system for the treatment of diabetic foot ulcers. This device promotes the healing process of diabetic foot ulcers by completely offloading the pressures that an ulcer may be subjected to regardless of its size, shape or location on the foot / ankle and / or toes. The device is made of a custom rigid outer shell and a custom inner lattice structure that fully supports, stabilizes and conforms to all aspects of a patient's condition, anomalies and disfigurement. It completely offloads (zero contact) any ulceration regardless of the location on the foot, ankle or toes. The offloading occurs through the use of recessed areas that can be incorporated directly into the lattice structure, or can be included in a "plug" that fits within a small aperture in the lattice structure.

The invention provides a foot ulcer risk screening instrument based on artificial intelligence, and relates to the field of foot ulcer risk screening instruments. The foot ulcer risk screening instrument based on artificial intelligence comprises a foot screening instrument, three vertical grooves are formed in each of the two sides of the front end of the foot screening instrument, three threaded rotating rods are arranged at the front ends of the inner walls of the vertical grooves, sliding blocks are arranged on the inner walls of the vertical grooves in a sliding mode, and connecting blocks are arranged at the rear ends of the sliding blocks. Limiting plates are arranged on the two sides of the rear ends of the connecting blocks in the middles of the two sides, limiting side plates are arranged on the two sides of the rear ends of the two sides of the connecting blocks on the two sides, and a detection side plate is arranged between every two adjacent limiting side plates. According to the invention, reasonable layout of foot dorsum, foot side and sole detection components is realized, three types of screening cameras are respectively corresponding to different areas of the foot, a structural basis is provided for comprehensive screening of multiple parts, and the problem of insufficient coverage of non-sole areas in traditional screening is effectively avoided.

The invention discloses a volatile oil supported hydrogel composite material as well as a preparation method and application thereof, and belongs to the technical field of medicine preparation. The composite material comprises sporopollen microcapsules loaded with volatile oil, and hydrogel formed by crosslinking four-arm polyethylene glycol amine and four-arm polyethylene glycol succinimide glutarate. The preparation method comprises the following steps: degreasing plant pollen, carrying out acid treatment to obtain sporopollen microcapsules, mixing the sporopollen microcapsules with volatile oil, and then blending and cross-linking with a polyethylene glycol derivative solution. The composite material can efficiently load volatile oil, realizes long-acting slow release, has excellent antibacterial performance and an effect of promoting wound healing, and can be used for treating chronic wounds such as diabetic foot ulcer and the like.

The invention relates to the field of rehabilitation medical treatment, in particular to exercise rehabilitation auxiliary wearable equipment suitable for diabetics and obese patients, which comprises a single chip microcomputer and a plantar pressure adjusting assembly, the plantar pressure adjusting assembly comprises an insole, a plurality of openings are formed in the insole, and a plurality of elastic membranes used for sealing the openings are fixedly connected to the top of the insole; the insole is provided with a sensing assembly used for monitoring plantar pressure, and the sensing assembly is located below the elastic membrane and is in signal connection with the single-chip microcomputer. The bottom of the insole is fixedly connected with a substrate layer, a plurality of air cavities are formed in the substrate layer, and the air cavities are communicated with the adjacent openings; folding assemblies used for enhancing the supporting rigidity of the elastic membranes are arranged in the air cavities. By collecting plantar pressure data and regulating and controlling the supporting rigidity of the elastic membrane and the folding assembly, dynamic adaptation of the plantar supporting rigidity is achieved, the risks of foot ulcers of diabetic patients and plantar strain of obese patients are reduced, and comfort and safety in the exercise rehabilitation process are improved.

The invention discloses a traditional Chinese medicine composition for treating long-term ulceration of trauma and a preparation method thereof, and relates to the technical field of traditional Chinese medicine, and the composition is prepared by compatibility of four medicinal materials including hairyvein agrimony charcoal, dragon bone calcined powder, scorched licorice powder and indigo naturalis powder through a special processing technology. The preparation method adopts a step-by-step temperature control calcining method and an equivalent incremental mixing method, so that stable release of pharmacodynamic substances is ensured. Clinical research shows that the composition can reduce the exudation of a traumatic exudate wound within 7 days by 83%, shorten the healing period of diabetic foot ulcer by 40%, and realize the synergistic effect of antibiosis and tissue regeneration by adjusting the pH value of a wound microenvironment. A quality control system covers 12 core indexes such as tannin and calcium ions, the accuracy is improved by more than 3 times compared with that of a traditional preparation, and a safe and effective traditional Chinese medicine solution is provided for refractory wounds.

The application discloses a functional low-frequency responsive piezoelectric hydrogel as well as a preparation method and application thereof, and belongs to the field of biomedical technology.The application provides the functional low-frequency responsive piezoelectric hydrogel in view of the defects of the existing piezoelectric hydrogel in the treatment of diabetic wound surfaces.The hydrogel has two forms, one is a temperature-sensitive piezoelectric hydrogel, and the other is a spray type piezoelectric hydrogel.Both the two gels are doped with a PVP modified piezoelectric catalytic material ZnO-CuO, which not only has a strong killing effect on bacteria and generates an electric signal, but also has a great effect on blood vessel formation and cell migration.The developed hydrogel can generate an electric signal to adjust the electrophysiological microenvironment of a wound surface, thereby affecting the behaviors of various cells and bacteria.The low-frequency responsive hydrogel with a piezoelectric enhancement effect can effectively accelerate the healing of a diabetic foot ulcer wound surface by promoting blood vessel regeneration and inhibiting bacterial infection, and provides a new idea for the application of a high-performance piezoelectric catalyst in the field of biomedicine.

This invention discloses a strain of Codonopsis pilosula endophytic fungus that produces extracellular polysaccharides and its applications. This Codonopsis pilosula endophytic fungus is a short-spore bacterium, named... Brevibacillus schisleri CpRG-1. The Codonopsis pilosula endophytic bacteria of the present invention exhibit excellent ability to produce extracellular polysaccharides, producing high concentrations of extracellular polysaccharides, which can greatly reduce the cost of extracting polysaccharides from the medicinal herb Codonopsis pilosula; at the same time, the extracellular polysaccharides produced by the Codonopsis pilosula endophytic bacteria not only have antibacterial and hypoglycemic activities, but also can promote the healing of diabetic foot ulcers and improve the intestinal microbiota, providing new ideas for the development of antibacterial drugs, diabetes prevention foods and drugs, and diabetic foot ulcer treatment foods and drugs.

The invention relates to the field of medical treatment and health, and discloses a diabetic foot ulcer electrical stimulation and medicine synergistic treatment device and a using method, the diabetic foot ulcer electrical stimulation and medicine synergistic treatment device comprises a flexible main body belt, the two sides of the flexible main body belt are both provided with binding belts, the surface of the left binding belt is provided with a hook face hook-and-loop fastener, and the surface of the right binding belt is provided with a suede face hook-and-loop fastener; and the electrical stimulation drug delivery synergistic structure is used for integrating electrical stimulation and transdermal drug delivery, so that the rehabilitation treatment of the foot ulcer is enhanced. Organic fusion of treatment means is achieved through an electrical stimulation drug delivery synergistic structure, and the limitation of single treatment is broken through: a platinum composite flexible electrode and a gold composite flexible electrode are matched with an electrical stimulation control module, wound surface microcirculation can be improved through low-frequency electrical stimulation, and meanwhile, a blood vessel dilating agent stored in a drug storage chamber can further enhance the microcirculation improvement effect; the anti-inflammatory drug can reduce local inflammatory response possibly caused by electrical stimulation, and the synergistic effect of stimulation synergy and drug side effect reduction is achieved.

The utility model discloses a leprosy patient foot ulcer seepage adsorption insole which comprises a macromolecule water absorption fiber insole body, a medical silica gel insole body is detachably arranged on the macromolecule water absorption fiber insole body, a plurality of seepage flow guide holes are formed in the medical silica gel insole body, and the seepage flow guide holes penetrate through the medical silica gel insole body. The insole has the advantages that wound exudate of a patient flows into the macromolecule water-absorbing fiber insole on the lower layer through the exudate flow guide holes, liquid retention on the surface of the insole is reduced, the wound is kept dry, and comfort is better. The medical silica gel insole is in contact with the foot of the patient, so that the comfort is better, and the pain of the patient is relieved. The detachable design is adopted between the macromolecule water-absorbing fiber insole and the medical silica gel insole, the macromolecule water-absorbing fiber insole can be independently detached after seepage adsorption is saturated, the medical silica gel insole can be repeatedly used after being cleaned and aired, and the long-term use cost is reduced.

The invention provides a preparation method of loropetalum chinense extract and application of the loropetalum chinense extract in preparation of products for diabetic ulcer, and relates to the technical field of traditional Chinese medicine extraction. The preparation method comprises the following steps: mixing a loropetalum chinense raw material, water and coriolus hirsutus, and carrying out enzymolysis to obtain an enzymolysis product; mixing the enzymolysis product with 80wt%-90wt% of an ethanol solution, and performing ultrasonic-assisted extraction to obtain a component 1; adsorbing the component 1 through macroporous adsorption resin, washing the resin with methanol, then eluting with an elution phase, collecting 10-30 min eluent, combining and drying to obtain the component 1; the elution phase is a mixture of methanol and propylene glycol. The loropetalum chinense extract is prepared through a specific preparation method, and the diabetic foot ulcer treatment effect of the loropetalum chinense extract is remarkably improved.

This invention provides the application of exercise-induced sweat extract from healthy individuals in the preparation of a topical medication for diabetic foot ulcers, belonging to the field of biomedicine. Addressing the problems of high cost and limited efficacy of existing treatments, this invention creatively proposes to collect, wash, centrifuge, and filter sweat from healthy individuals induced by specific moderate-intensity aerobic exercise to prepare a sterile extract, which can be used as an active ingredient for topical treatment of diabetic foot ulcers. This sweat extract is rich in various bioactive components. In vitro transcriptomic analysis shows that it can reverse the abnormal gene expression profile associated with diabetic foot ulcers. In vivo animal experiments have confirmed that its topical application can significantly accelerate the healing of diabetic wounds through multi-target synergistic effects of anti-inflammation, angiogenesis, epithelialization, and collagen deposition, with effects comparable to recombinant growth factors. This invention provides a novel treatment strategy that is natural, safe, low-cost, and highly effective, with broad clinical application prospects.

The utility model relates to the technical field of foot bath barrels, in particular to a foot bath barrel for foot ulcer. The foot bath barrel for the foot ulcer comprises a barrel body, a bearing assembly for supporting the foot sole is arranged in the barrel body, and a sealing assembly for shielding the top of the barrel body is arranged at the top of the barrel body; the sealing assembly comprises a top cover, two symmetrically-distributed mounting grooves are formed in the top cover, rubber sheets are arranged in the mounting grooves, through holes are formed in the centers of the rubber sheets, convex rings are arranged on the edge of the top of the top cover, and connecting grooves are formed in the top of the barrel body. And the inner wall of the connecting groove is in threaded connection with the outer wall of the top cover. According to the foot bath barrel for the foot ulcers, due to the arrangement of the sealing assembly, the top of the barrel body can be sealed during foot bath, so that steam diffusion can be reduced, the foot bath effect can be improved in an auxiliary mode, and meanwhile the influence on breathing of a patient due to the fact that medicine smell diffuses into air can be reduced.

The invention relates to the field of diabetic foot ulcer, and discloses a diabetic foot ulcer wound edge skin-derived extracellular vesicle as well as a preparation method and application thereof. The preparation method comprises the following steps: pretreating diabetic foot ulcer wound edge skin tissues to obtain tissue fragments; the method comprises the following steps: mixing type IV collagenase and DNaseI enzyme in a DMEM (Dulbecco Modified Eagle Medium) high-glucose culture medium to prepare a tissue dissociation solution; carrying out primary dissociation by using pancreatin digestive juice, and then carrying out secondary dissociation by using tissue dissociation liquid; sequentially and alternately carrying out gradient size filtration and differential centrifugation on the filtrate, and collecting supernate; performing ultra-high-speed centrifugation, ultra-filtration and gradient needle type filtration on the supernate; and performing ultra-high-speed centrifugation again to obtain the diabetic foot ulcer wound edge skin-derived extracellular vesicles. The concentration of the obtained EVs is 3.29 mg / mL, and the characteristics of delayed healing and insufficient collagen deposition can be stably obtained by injecting the EVs into normal mice.

The present application belongs to the field of diabetic foot wound treatment, and particularly relates to a recombinant natural enzyme nanogel, a preparation method and application thereof. The recombinant natural enzyme nanogel comprises a recombinant natural nanoenzyme, a carrier material, a gel matrix, a humectant and a buffer, and has a good clinical effect on promoting the healing of a diabetic foot wound. The recombinant natural enzyme nanogel, the preparation method and the application thereof have the advantages that the remodeling of a microenvironment of a diabetic foot wound and tissue regeneration can be realized through an intelligent cascade reaction of a recombinant natural enzyme, and the recombinant natural enzyme nanogel is a new treatment method which is non-invasive, simple, safe and highly compliant, and is expected to become an auxiliary treatment method for the healing of a diabetic foot wound in the future, and is also helpful to tissue regeneration and rapid healing of a foot ulcer patient.

Nanoparticle-Based Smart Dressing for Real-Time Healing of Chronic Diabetic Foot Ulcers

The present application discloses polymorphs of asiaticoside, a preparation method and medical use thereof. The present application firstly proves that asiaticoside has polymorphism, and provides various crystal forms of asiaticoside suitable for being used as a raw material, which can be used for developing asiaticoside preparations with controllable quality. The present application provides a simple, easy and environment-friendly preparation method of the polymorphs of asiaticoside, which is suitable for large-scale production. The polymorphs of asiaticoside or pharmaceutical compositions containing the crystal forms of asiaticoside can be used for preventing and treating diseases including type I interferon disease, peptic ulcer, Parkinson's disease, ulcerative colitis, systemic sclerosis, liver fibrosis, pulmonary fibrosis, renal fibrosis, Alzheimer's disease, depression, diabetic foot ulcer and refractory wound.

The application discloses a novel brown algae polysaccharide SARP for promoting healing of diabetic ulcers and a preparation and application thereof. A novel SARP is obtained through Sephacryl S-300 / HR gel column separation and purification, and the molecular weight of the SARP is about 45.4 kDa, which is composed of mannuronic acid (76.56%), guluronic acid (18.89%) and a small amount of glucuronic acid (4.55%). Compared with alginate separated from other brown algae, the SARP has a higher content of mannuronic acid. The SARP shows a better in-vitro antioxidant capacity, and can obviously reverse the cell damage of HUVECs caused by H2O2 and high sugar in the HUVECs. In addition, the SARP can promote the migration and tubular formation of the HUVECs. In-vivo experiments further show that the SARP can promote the healing of diabetic ulcer in rats, and can reduce the oxidative stress, inflammation level and lipid disorder in the rats. The SARP has a simple purification route, can be prepared in a large amount, and is a very promising novel drug for treating diabetic foot ulcers.

The present invention is a diabetic healing system for the treatment of diabetic foot ulcers. This device promotes the healing process of diabetic foot ulcers by completely offloading the pressures that an ulcer may be subjected to regardless of its size, shape or location on the foot / ankle and / or toes. The device is made of a custom rigid outer shell and a custom inner lattice structure that fully supports, stabilizes and conforms to all aspects of a patient's condition, anomalies and disfigurement. It completely offloads (zero contact) any ulceration regardless of the location on the foot, ankle or toes. The offloading occurs through the use of recessed areas that can be incorporated directly into the lattice structure, or can be included in a “plug” that fits within a small aperture in the lattice structure.

The present invention relates to a mechanical wound cleansing device comprising a carrier layer and an abrasive loop system arranged above the carrier layer, whereby the loop system is an intermeshed fiber system which is intermeshed above the carrier layer and / or a loop system comprising highly and softly abrasive loops. The present invention further relates to a method of producing said mechanical wound cleansing device. The present invention finally relates to the use of said wound cleansing device for the abrasive removal of and cleansing of wounds, especially for venous leg ulcers, diabetic foot ulcers (neuropathic and neuro-ischemic), arterial ulcers, mixed etiology ulcers, pressure ulcers or traumatic wounds.

The invention discloses a traditional Chinese medicine formula for treating diabetic foot and bedsore, and relates to the technical field of traditional Chinese medicine external preparations, the traditional Chinese medicine formula comprises the following medicinal materials in parts by weight: nidus vespae, carbonized hair, coptis chinensis, golden cypress, scutellaria baicalensis, rheum officinale, centipede, scorpion and the like, the components have a synergistic effect under a preferable ratio, and the formula is 80-120-mesh external powder. The traditional Chinese medicine composition is prepared through independent crushing, three-dimensional mixing and other processes, can be used for preparing external medicines for diabetic foot ulcer and bedsore, and can achieve integrated treatment of counteracting toxic substances and removing decay, dispersing blood stasis and promoting tissue regeneration, and astringing sores and closing up.

The invention provides application of secreted protein insulin-like growth factor binding protein 7 (IGFBP7) in diabetic foot ulcer attack risk prediction of diabetic patients, and belongs to the technical field of biological medicine. Through single cell sequencing, the secretory protein IGFBP7 is found to be highly expressed in smooth muscle cells of the diabetic foot ulcer disease site of a diabetic patient, so that the secretory protein IGFBP7 can be used as a marker for predicting the diabetic foot ulcer disease risk of the diabetic patient. The invention provides a new method for predicting the attack risk of diabetic foot ulcer of diabetic patients, and has important clinical value.

The present application relates to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating diabetic foot and a preparation method thereof.The traditional Chinese medicine composition is made of the following weight parts of traditional Chinese medicine raw materials: 180-220 parts of raw astragalus, 140-160 parts of angelica, 90-120 parts of dogwood, 180-220 parts of coptis, 180-220 parts of scrophulariaceae, 90-120 parts of atractylodes, 90-120 parts of cortex phellodendri, 40-60 parts of white yam, 40-60 parts of pearl powder, 40-60 parts of geum japonicum and 4-8 parts of artificial musk.The traditional Chinese medicine composition has the effects of benefiting qi and nourishing blood, nourishing yin and purging fire, clearing heat and drying dampness, promoting blood circulation and generating muscle, and has a good therapeutic effect on foot ulcer caused by diabetes.Moreover, the traditional Chinese medicine composition is safe and effective for long-term use, and the patient is not prone to recurrence.

The invention provides application of arbutin in preparation of a medicine for promoting wound healing of diabetic foot ulcer, and relates to the technical field of biomedicine, in the application, through animal experiments and cell experiments, the treatment effect of external-use arbutin cream on diabetic foot ulcer healing is systematically evaluated, and the action mechanism of the external-use arbutin cream is explored. In the research, a diabetic foot ulcer rat model is constructed, drug administration treatment is carried out in groups, meanwhile, related experiments are carried out on human prepuce fibroblasts, and through multiple detection methods and statistical analysis, it is proved that the arbutin cream plays a positive role in promoting wound healing, granulation tissue formation, collagen deposition, fibroblast migration and the like.

A system for evaluating the efficacy of honey and hydrogel in the treatment of diabetic foot ulcers in patients with type 2 diabetes mellitus, comprising: a) a wound preparation unit configured for the surgical removal of necrotic tissue and calluses in diabetic foot ulcers; b) a topical treatment unit configured to apply at least one therapeutic agent selected from the group consisting of honey gel, hydrogel, a combination of honey gel and hydrogel, or topical antibiotic ointment to the wound bed; c) a relief unit configured to provide pressure relief devices for the ulcer site; and d) a monitoring unit configured to measure wound size and track healing progress at predetermined intervals.

The invention discloses a treatment-sensing integrated insole for diabetic foot ulcer and a preparation method of the treatment-sensing integrated insole, and belongs to the technical field of functional materials. The treatment-sensing integrated insole for the diabetic foot ulcer comprises an insole base body and a nitrogen-doped carbon sponge embedded in the insole base body, the insole base body is hydrogel containing natural antibacterial substances; the nitrogen-doped carbon sponge is connected with a wire, and the wire is connected with an external friction power generation device and / or a signal transmission device. According to the treatment-sensing integrated insole for diabetic foot ulcer, the major defect of diabetic foot ulcer wound nursing is overcome, the sensing function and the treatment function are organically combined in one system, prevention and rehabilitation can be truly integrated, and the nursing pressure of the foot ulcer is relieved.

A peptide-ionic liquid conjugate for the prevention and / or treatment of skin disorders. The peptide-ionic liquid conjugate comprises a cosmeceutical peptide comprising up to 10 amino acids and at least one ionic liquid comprising saturated or unsaturated hydrocarbon chain substituents from C1 to C18. The peptide-ionic liquid conjugates herein disclosed are suitable against skin disorders, such as, e.g., melanoma, non-melanoma skin cancers, diabetic foot ulcers, venous leg ulcers, pressure ulcers, acne, candidiasis, cellulitis, dermatophytoses, erysipelas, folliculitis, impetigo, psoriasis, rosacea, or eczema (atopic dermatitis), since they present potent activity against either antibiotic-susceptible strains or multidrug resistant clinical isolates of both Gram-positive and Gram-negative, a bactericidal type of action, anti-inflammatory and immunomodulatory effects, and collagenesis-inducing effects. Further disclosing a topical composition comprising the peptide-ionic liquid conjugates and uses thereof.