54 results about "Foot ulcer" patented technology

The invention relates to the technical field of biomarkers, in particular to a biomarker composition for diabetic foot ulcer and application of the biomarker composition. The invention provides a biomarker combination for diabetic foot ulcer. The biomarker combination comprises a DDIT4 gene and a PKM gene. According to the invention, by integrating transcriptome sequencing data and single cell sequencing data, biomarkers DDIT4 and PKM closely related to diabetic foot ulcer (DFU) are successfully screened out. The expression of the two genes in a disease group is remarkably up-regulated, and the two genes are stably expressed in different data sets, so that a reliable molecular target is provided for early diagnosis of DFU.

The present application relates to the technical field of biological medicine, and particularly relates to a stem cell culture method for promoting wound healing and application thereof. The stem cell culture method for promoting wound healing comprises the following steps: step one, providing umbilical cord-derived mesenchymal stem cells; step two, adding luteolin and baicalin as culture medium additives in a serum-supplemented culture medium, wherein the concentration of luteolin is 1-10 micromoles / L, and the concentration of baicalin is 1-10 micromoles / L; step three, inoculating the mesenchymal stem cells into the culture medium containing the additives for culture, and the culture condition is 34-40 DEG C, 4-6% CO2, and the culture time is 48-96 hours; step four, harvesting the cultured mesenchymal stem cells to obtain stem cells for promoting wound healing. The culture method can promote the stem cells to secrete various growth factors, significantly improve the secretion of PGE2 and VEGF-C growth factors, and make the wound healing rate of the stem cell treatment group reach 96%, which has a significant effect on treating diabetic foot ulcers.

The invention provides a pharmaceutical composition for treating diabetic foot ulcer as well as a preparation method and application thereof, and the pharmaceutical composition for treating diabetic foot ulcer is prepared by taking angelica sinensis, honeysuckle and scutellaria baicalensis as raw materials through pretreatment, extraction and post-treatment. The pharmaceutical composition for treating diabetic foot ulcer disclosed by the invention has a good curative effect on diabetic foot ulcer diseases; especially, an oral prescription and an external prescription are matched for use, so that the curative effect is better.

The present invention discloses the application of a conductive hydrogel combined with electrical stimulation in the treatment of diabetic foot ulcers caused by neuropathy, belonging to the field of biomedicine. The conductive hydrogel is obtained by mixing chitosan, polyvinyl alcohol, MXene and gelatin. The chitosan is chitosan modified with catechol groups, the MXene is MXene modified with polyphenols and Mg ions, and the gelatin is gelatin modified with phenylboronic acid. The condition of the electrical stimulation is 100 mV cm-1. The diabetic foot ulcers include diabetic foot ulcers caused by neuropathy. Through experimental verification, the conductive hydrogel prepared by the present invention combined with electrical stimulation can promote cell migration, accelerate the wound healing of diabetic foot ulcers and achieve functional repair. The present invention provides a new idea for the clinical treatment of diabetic foot ulcers caused by neuropathy.

The utility model discloses a diabetic foot ulcer treatment dressing change device, which comprises a shoe frame, a bottom plate and a detachable component, the inner surface of the shoe frame is fixedly connected with a breathable sheet, the lower surface of the breathable sheet is provided with a medicine pad, the inner part of the shoe frame is provided with a plug pin, and the plug pin is connected with the bottom plate. The detachable assembly comprises a first limiting block, a sliding block, a sliding column, a sleeve, a spring, a clamping block and a second limiting block, the inner wall of the first limiting block is slidably connected with the sliding block, the interior of the sliding block is fixedly connected with the sliding column, the side surface of the sliding column is slidably connected with the sleeve, and the sleeve penetrates through the interior of the spring; by means of the detachable assembly, the foot pad at the bottom of the foot mold can be replaced, a traditional adhesion type foot patch dressing change mode is replaced, mounting and dismounting operation is easy and convenient, pain of a patient in the dressing change process can be reduced, the comfort level of the patient is greatly improved, and high practicability is achieved.

The present invention belongs to the field of preparation of diabetes complication remission agents, and particularly relates to a combined preparation for improving microcirculation of diabetic foot and a preparation method thereof. Starting from platelet-rich plasma, the present invention obtains exosomes containing rich active substances such as growth factors through stimulation with calcium gluconate and the like, and loads protamine nanoparticles to obtain bioactive substances with strong antibacterial ability, which can resist the development process of diabetic foot ulcers. The present invention uses bioactive glass, hydroxyethyl cellulose and the like to stabilize the bioactive substances, prolong the in vitro lifespan of the bioactive substances, and modified carboxymethyl cellulose provides better biodegradation effect. The combined preparation prepared by the present invention has less cytotoxicity, better antibacterial effect, can promote wound healing quickly, and the microcirculation index shows that it can stimulate the change of foot blood flow and improve the condition of foot artery blockage, etc.

According to various embodiments, a server for predicting determination on a diabetic foot on the basis of a plurality of pieces of data on the basis of a prediction model, comprises: a communication interface; a memory; and a processor, wherein the processor is configured to: obtain at least one piece of image data and at least one piece of first sensing data from an external server of an external user through the communication interface; obtain first ulcer output data by inputting the at least one piece of image data and the at least one piece of first sensing data to the prediction model; when it is determined that the first ulcer output data exceeds a preset first threshold value on the basis of a result of comparing the first ulcer output data with the preset first threshold value, output that a foot ulcer of the external user is likely to be diabetic foot ulcer; when it is determined that the first ulcer output data exceeds a second threshold value set to be greater than the first threshold value on the basis of a result of comparing the first ulcer output data with the second threshold value, output that the foot ulcer of the external user is highly likely to be the diabetic foot ulcer; and transmit, through the communication interface, result data for the first ulcer output data determined to exceed the first threshold value and / or the second threshold value, and guideline data presenting at least one guideline on the basis of the result data, wherein the prediction model is trained on the basis of a plurality of pieces of image data, a plurality of pieces of first sensing data, and a plurality of pieces of second sensing data, which are obtained from a plurality of users, a plurality of pieces of result data output from the plurality of users, and at least one piece of professional opinion data obtained by observing the plurality of users.

The present invention is a diabetic healing system for the treatment of diabetic foot ulcers. This device promotes the healing process of diabetic foot ulcers by completely offloading the pressures that an ulcer may be subjected to regardless of its size, shape or location on the foot / ankle and / or toes. The device is made of a custom rigid outer shell and a custom inner lattice structure that fully supports, stabilizes and conforms to all aspects of a patient's condition, anomalies and disfigurement. It completely offloads (zero contact) any ulceration regardless of the location on the foot, ankle or toes. The offloading occurs through the use of recessed areas that can be incorporated directly into the lattice structure, or can be included in a "plug" that fits within a small aperture in the lattice structure.

The invention provides a foot ulcer risk screening instrument based on artificial intelligence, and relates to the field of foot ulcer risk screening instruments. The foot ulcer risk screening instrument based on artificial intelligence comprises a foot screening instrument, three vertical grooves are formed in each of the two sides of the front end of the foot screening instrument, three threaded rotating rods are arranged at the front ends of the inner walls of the vertical grooves, sliding blocks are arranged on the inner walls of the vertical grooves in a sliding mode, and connecting blocks are arranged at the rear ends of the sliding blocks. Limiting plates are arranged on the two sides of the rear ends of the connecting blocks in the middles of the two sides, limiting side plates are arranged on the two sides of the rear ends of the two sides of the connecting blocks on the two sides, and a detection side plate is arranged between every two adjacent limiting side plates. According to the invention, reasonable layout of foot dorsum, foot side and sole detection components is realized, three types of screening cameras are respectively corresponding to different areas of the foot, a structural basis is provided for comprehensive screening of multiple parts, and the problem of insufficient coverage of non-sole areas in traditional screening is effectively avoided.

The invention discloses a volatile oil supported hydrogel composite material as well as a preparation method and application thereof, and belongs to the technical field of medicine preparation. The composite material comprises sporopollen microcapsules loaded with volatile oil, and hydrogel formed by crosslinking four-arm polyethylene glycol amine and four-arm polyethylene glycol succinimide glutarate. The preparation method comprises the following steps: degreasing plant pollen, carrying out acid treatment to obtain sporopollen microcapsules, mixing the sporopollen microcapsules with volatile oil, and then blending and cross-linking with a polyethylene glycol derivative solution. The composite material can efficiently load volatile oil, realizes long-acting slow release, has excellent antibacterial performance and an effect of promoting wound healing, and can be used for treating chronic wounds such as diabetic foot ulcer and the like.

The invention relates to the field of rehabilitation medical treatment, in particular to exercise rehabilitation auxiliary wearable equipment suitable for diabetics and obese patients, which comprises a single chip microcomputer and a plantar pressure adjusting assembly, the plantar pressure adjusting assembly comprises an insole, a plurality of openings are formed in the insole, and a plurality of elastic membranes used for sealing the openings are fixedly connected to the top of the insole; the insole is provided with a sensing assembly used for monitoring plantar pressure, and the sensing assembly is located below the elastic membrane and is in signal connection with the single-chip microcomputer. The bottom of the insole is fixedly connected with a substrate layer, a plurality of air cavities are formed in the substrate layer, and the air cavities are communicated with the adjacent openings; folding assemblies used for enhancing the supporting rigidity of the elastic membranes are arranged in the air cavities. By collecting plantar pressure data and regulating and controlling the supporting rigidity of the elastic membrane and the folding assembly, dynamic adaptation of the plantar supporting rigidity is achieved, the risks of foot ulcers of diabetic patients and plantar strain of obese patients are reduced, and comfort and safety in the exercise rehabilitation process are improved.

The invention discloses a traditional Chinese medicine composition for treating long-term ulceration of trauma and a preparation method thereof, and relates to the technical field of traditional Chinese medicine, and the composition is prepared by compatibility of four medicinal materials including hairyvein agrimony charcoal, dragon bone calcined powder, scorched licorice powder and indigo naturalis powder through a special processing technology. The preparation method adopts a step-by-step temperature control calcining method and an equivalent incremental mixing method, so that stable release of pharmacodynamic substances is ensured. Clinical research shows that the composition can reduce the exudation of a traumatic exudate wound within 7 days by 83%, shorten the healing period of diabetic foot ulcer by 40%, and realize the synergistic effect of antibiosis and tissue regeneration by adjusting the pH value of a wound microenvironment. A quality control system covers 12 core indexes such as tannin and calcium ions, the accuracy is improved by more than 3 times compared with that of a traditional preparation, and a safe and effective traditional Chinese medicine solution is provided for refractory wounds.

The invention relates to the technical field of biological medicine, in particular to a stem cell culture method capable of promoting wound healing and application thereof. The stem cell culture method capable of promoting wound healing comprises the following steps: step 1, providing umbilical cord-derived mesenchymal stem cells; 2, luteolin and baicalin are added into the serum supplement culture medium to serve as culture medium additives, the concentration of the luteolin is 1-10 [mu] mol / L, and the concentration of the baicalin is 1-10 [mu] mol / L; 3, inoculating the mesenchymal stem cells into a culture medium containing an additive, and culturing for 48-96 hours under the culture conditions that the temperature is 34-40 DEG C, the CO2 content is 4-6% and the culture time is 48-96 hours; 4, the cultured mesenchymal stem cells are harvested, and the stem cells capable of promoting wound healing are obtained. According to the culture method, stem cells can be promoted to secrete multiple growth factors, secretion of PGE2 and VEGF-C growth factors is remarkably improved, the wound healing rate of a stem cell treatment group is increased to 96%, and the culture method has a remarkable effect on treating diabetic foot ulcer.

The application discloses a functional low-frequency responsive piezoelectric hydrogel as well as a preparation method and application thereof, and belongs to the field of biomedical technology.The application provides the functional low-frequency responsive piezoelectric hydrogel in view of the defects of the existing piezoelectric hydrogel in the treatment of diabetic wound surfaces.The hydrogel has two forms, one is a temperature-sensitive piezoelectric hydrogel, and the other is a spray type piezoelectric hydrogel.Both the two gels are doped with a PVP modified piezoelectric catalytic material ZnO-CuO, which not only has a strong killing effect on bacteria and generates an electric signal, but also has a great effect on blood vessel formation and cell migration.The developed hydrogel can generate an electric signal to adjust the electrophysiological microenvironment of a wound surface, thereby affecting the behaviors of various cells and bacteria.The low-frequency responsive hydrogel with a piezoelectric enhancement effect can effectively accelerate the healing of a diabetic foot ulcer wound surface by promoting blood vessel regeneration and inhibiting bacterial infection, and provides a new idea for the application of a high-performance piezoelectric catalyst in the field of biomedicine.

This invention discloses a strain of Codonopsis pilosula endophytic fungus that produces extracellular polysaccharides and its applications. This Codonopsis pilosula endophytic fungus is a short-spore bacterium, named... Brevibacillus schisleri CpRG-1. The Codonopsis pilosula endophytic bacteria of the present invention exhibit excellent ability to produce extracellular polysaccharides, producing high concentrations of extracellular polysaccharides, which can greatly reduce the cost of extracting polysaccharides from the medicinal herb Codonopsis pilosula; at the same time, the extracellular polysaccharides produced by the Codonopsis pilosula endophytic bacteria not only have antibacterial and hypoglycemic activities, but also can promote the healing of diabetic foot ulcers and improve the intestinal microbiota, providing new ideas for the development of antibacterial drugs, diabetes prevention foods and drugs, and diabetic foot ulcer treatment foods and drugs.

The invention relates to the field of medical treatment and health, and discloses a diabetic foot ulcer electrical stimulation and medicine synergistic treatment device and a using method, the diabetic foot ulcer electrical stimulation and medicine synergistic treatment device comprises a flexible main body belt, the two sides of the flexible main body belt are both provided with binding belts, the surface of the left binding belt is provided with a hook face hook-and-loop fastener, and the surface of the right binding belt is provided with a suede face hook-and-loop fastener; and the electrical stimulation drug delivery synergistic structure is used for integrating electrical stimulation and transdermal drug delivery, so that the rehabilitation treatment of the foot ulcer is enhanced. Organic fusion of treatment means is achieved through an electrical stimulation drug delivery synergistic structure, and the limitation of single treatment is broken through: a platinum composite flexible electrode and a gold composite flexible electrode are matched with an electrical stimulation control module, wound surface microcirculation can be improved through low-frequency electrical stimulation, and meanwhile, a blood vessel dilating agent stored in a drug storage chamber can further enhance the microcirculation improvement effect; the anti-inflammatory drug can reduce local inflammatory response possibly caused by electrical stimulation, and the synergistic effect of stimulation synergy and drug side effect reduction is achieved.

The utility model discloses a leprosy patient foot ulcer seepage adsorption insole which comprises a macromolecule water absorption fiber insole body, a medical silica gel insole body is detachably arranged on the macromolecule water absorption fiber insole body, a plurality of seepage flow guide holes are formed in the medical silica gel insole body, and the seepage flow guide holes penetrate through the medical silica gel insole body. The insole has the advantages that wound exudate of a patient flows into the macromolecule water-absorbing fiber insole on the lower layer through the exudate flow guide holes, liquid retention on the surface of the insole is reduced, the wound is kept dry, and comfort is better. The medical silica gel insole is in contact with the foot of the patient, so that the comfort is better, and the pain of the patient is relieved. The detachable design is adopted between the macromolecule water-absorbing fiber insole and the medical silica gel insole, the macromolecule water-absorbing fiber insole can be independently detached after seepage adsorption is saturated, the medical silica gel insole can be repeatedly used after being cleaned and aired, and the long-term use cost is reduced.

The invention provides an effect of a sugar foot health cream in promoting wound healing of sugar foot ulcer, relates to the technical field of traditional Chinese medicine components, and is technically characterized in that the sugar foot health cream is used for promoting wound healing of sugar foot ulcer and comprises the following traditional Chinese medicine components: rhizoma atractylodis, cortex phellodendri, semen coicis, cortex cinnamomi, radix angelicae sinensis, radix astragali and borneol. According to the application, a rat lower limb ischemic type 1 DFU model is constructed, and the model verifies that the Gangsukang ointment provided by the application is suitable for various DFU dialectical types; and by improving the dosage form, the preparation can be directly applied to the wound surface, so that the curative effect is improved, the stimulation to the wound surface is reduced, and the compliance of a patient is enhanced. Cream is a multi-component traditional Chinese medicine and can improve the anti-inflammatory effect; wound tissue regeneration is promoted; the ulcer surface healing is accelerated.

The invention provides a preparation method of loropetalum chinense extract and application of the loropetalum chinense extract in preparation of products for diabetic ulcer, and relates to the technical field of traditional Chinese medicine extraction. The preparation method comprises the following steps: mixing a loropetalum chinense raw material, water and coriolus hirsutus, and carrying out enzymolysis to obtain an enzymolysis product; mixing the enzymolysis product with 80wt%-90wt% of an ethanol solution, and performing ultrasonic-assisted extraction to obtain a component 1; adsorbing the component 1 through macroporous adsorption resin, washing the resin with methanol, then eluting with an elution phase, collecting 10-30 min eluent, combining and drying to obtain the component 1; the elution phase is a mixture of methanol and propylene glycol. The loropetalum chinense extract is prepared through a specific preparation method, and the diabetic foot ulcer treatment effect of the loropetalum chinense extract is remarkably improved.

The invention discloses a targeting stem cell exosome composition and application thereof in treating diabetic foot ulcer. According to the composition, a mesenchymal stem cell exosome is modified through genetic engineering, specific targeting fusion polypeptide is expressed on the surface of the mesenchymal stem cell exosome, anti-inflammatory miR-146a and a pro-angiogenic factor VEGF are loaded, and then the mesenchymal stem cell exosome is compounded with temperature-sensitive hyaluronic acid hydrogel to form a sustained release system. The sequence of the fusion polypeptide is as shown in SEQ ID NO: 1, and the targeting of exosomes to diabetic inflammation parts is remarkably improved; the stability of miR-146a is enhanced through chemical modification, and the miR-146a cooperates with VEGF to inhibit inflammation and promote revascularization. In-vitro experiments show that the composition reduces the levels of TNF-alpha and IL-6 by 85% and 88% respectively, and the cell migration rate reaches 99.3%; in-vivo experiments show that the wound healing rate of diabetic rats reaches 99.6% on the 14th day, and the collagen deposition area proportion is increased to 77.5%. The invention has targeting property, function synergy and slow release performance, and provides an efficient treatment strategy for diabetic foot ulcer.

This invention provides the application of exercise-induced sweat extract from healthy individuals in the preparation of a topical medication for diabetic foot ulcers, belonging to the field of biomedicine. Addressing the problems of high cost and limited efficacy of existing treatments, this invention creatively proposes to collect, wash, centrifuge, and filter sweat from healthy individuals induced by specific moderate-intensity aerobic exercise to prepare a sterile extract, which can be used as an active ingredient for topical treatment of diabetic foot ulcers. This sweat extract is rich in various bioactive components. In vitro transcriptomic analysis shows that it can reverse the abnormal gene expression profile associated with diabetic foot ulcers. In vivo animal experiments have confirmed that its topical application can significantly accelerate the healing of diabetic wounds through multi-target synergistic effects of anti-inflammation, angiogenesis, epithelialization, and collagen deposition, with effects comparable to recombinant growth factors. This invention provides a novel treatment strategy that is natural, safe, low-cost, and highly effective, with broad clinical application prospects.

The utility model relates to the technical field of foot bath barrels, in particular to a foot bath barrel for foot ulcer. The foot bath barrel for the foot ulcer comprises a barrel body, a bearing assembly for supporting the foot sole is arranged in the barrel body, and a sealing assembly for shielding the top of the barrel body is arranged at the top of the barrel body; the sealing assembly comprises a top cover, two symmetrically-distributed mounting grooves are formed in the top cover, rubber sheets are arranged in the mounting grooves, through holes are formed in the centers of the rubber sheets, convex rings are arranged on the edge of the top of the top cover, and connecting grooves are formed in the top of the barrel body. And the inner wall of the connecting groove is in threaded connection with the outer wall of the top cover. According to the foot bath barrel for the foot ulcers, due to the arrangement of the sealing assembly, the top of the barrel body can be sealed during foot bath, so that steam diffusion can be reduced, the foot bath effect can be improved in an auxiliary mode, and meanwhile the influence on breathing of a patient due to the fact that medicine smell diffuses into air can be reduced.

The invention relates to the field of diabetic foot ulcer, and discloses a diabetic foot ulcer wound edge skin-derived extracellular vesicle as well as a preparation method and application thereof. The preparation method comprises the following steps: pretreating diabetic foot ulcer wound edge skin tissues to obtain tissue fragments; the method comprises the following steps: mixing type IV collagenase and DNaseI enzyme in a DMEM (Dulbecco Modified Eagle Medium) high-glucose culture medium to prepare a tissue dissociation solution; carrying out primary dissociation by using pancreatin digestive juice, and then carrying out secondary dissociation by using tissue dissociation liquid; sequentially and alternately carrying out gradient size filtration and differential centrifugation on the filtrate, and collecting supernate; performing ultra-high-speed centrifugation, ultra-filtration and gradient needle type filtration on the supernate; and performing ultra-high-speed centrifugation again to obtain the diabetic foot ulcer wound edge skin-derived extracellular vesicles. The concentration of the obtained EVs is 3.29 mg / mL, and the characteristics of delayed healing and insufficient collagen deposition can be stably obtained by injecting the EVs into normal mice.

The present application belongs to the field of diabetic foot wound treatment, and particularly relates to a recombinant natural enzyme nanogel, a preparation method and application thereof. The recombinant natural enzyme nanogel comprises a recombinant natural nanoenzyme, a carrier material, a gel matrix, a humectant and a buffer, and has a good clinical effect on promoting the healing of a diabetic foot wound. The recombinant natural enzyme nanogel, the preparation method and the application thereof have the advantages that the remodeling of a microenvironment of a diabetic foot wound and tissue regeneration can be realized through an intelligent cascade reaction of a recombinant natural enzyme, and the recombinant natural enzyme nanogel is a new treatment method which is non-invasive, simple, safe and highly compliant, and is expected to become an auxiliary treatment method for the healing of a diabetic foot wound in the future, and is also helpful to tissue regeneration and rapid healing of a foot ulcer patient.

Nanoparticle-Based Smart Dressing for Real-Time Healing of Chronic Diabetic Foot Ulcers

The present application discloses polymorphs of asiaticoside, a preparation method and medical use thereof. The present application firstly proves that asiaticoside has polymorphism, and provides various crystal forms of asiaticoside suitable for being used as a raw material, which can be used for developing asiaticoside preparations with controllable quality. The present application provides a simple, easy and environment-friendly preparation method of the polymorphs of asiaticoside, which is suitable for large-scale production. The polymorphs of asiaticoside or pharmaceutical compositions containing the crystal forms of asiaticoside can be used for preventing and treating diseases including type I interferon disease, peptic ulcer, Parkinson's disease, ulcerative colitis, systemic sclerosis, liver fibrosis, pulmonary fibrosis, renal fibrosis, Alzheimer's disease, depression, diabetic foot ulcer and refractory wound.

The application discloses a novel brown algae polysaccharide SARP for promoting healing of diabetic ulcers and a preparation and application thereof. A novel SARP is obtained through Sephacryl S-300 / HR gel column separation and purification, and the molecular weight of the SARP is about 45.4 kDa, which is composed of mannuronic acid (76.56%), guluronic acid (18.89%) and a small amount of glucuronic acid (4.55%). Compared with alginate separated from other brown algae, the SARP has a higher content of mannuronic acid. The SARP shows a better in-vitro antioxidant capacity, and can obviously reverse the cell damage of HUVECs caused by H2O2 and high sugar in the HUVECs. In addition, the SARP can promote the migration and tubular formation of the HUVECs. In-vivo experiments further show that the SARP can promote the healing of diabetic ulcer in rats, and can reduce the oxidative stress, inflammation level and lipid disorder in the rats. The SARP has a simple purification route, can be prepared in a large amount, and is a very promising novel drug for treating diabetic foot ulcers.

The present invention is a diabetic healing system for the treatment of diabetic foot ulcers. This device promotes the healing process of diabetic foot ulcers by completely offloading the pressures that an ulcer may be subjected to regardless of its size, shape or location on the foot / ankle and / or toes. The device is made of a custom rigid outer shell and a custom inner lattice structure that fully supports, stabilizes and conforms to all aspects of a patient's condition, anomalies and disfigurement. It completely offloads (zero contact) any ulceration regardless of the location on the foot, ankle or toes. The offloading occurs through the use of recessed areas that can be incorporated directly into the lattice structure, or can be included in a “plug” that fits within a small aperture in the lattice structure.

The present invention relates to a mechanical wound cleansing device comprising a carrier layer and an abrasive loop system arranged above the carrier layer, whereby the loop system is an intermeshed fiber system which is intermeshed above the carrier layer and / or a loop system comprising highly and softly abrasive loops. The present invention further relates to a method of producing said mechanical wound cleansing device. The present invention finally relates to the use of said wound cleansing device for the abrasive removal of and cleansing of wounds, especially for venous leg ulcers, diabetic foot ulcers (neuropathic and neuro-ischemic), arterial ulcers, mixed etiology ulcers, pressure ulcers or traumatic wounds.

The invention discloses a traditional Chinese medicine formula for treating diabetic foot and bedsore, and relates to the technical field of traditional Chinese medicine external preparations, the traditional Chinese medicine formula comprises the following medicinal materials in parts by weight: nidus vespae, carbonized hair, coptis chinensis, golden cypress, scutellaria baicalensis, rheum officinale, centipede, scorpion and the like, the components have a synergistic effect under a preferable ratio, and the formula is 80-120-mesh external powder. The traditional Chinese medicine composition is prepared through independent crushing, three-dimensional mixing and other processes, can be used for preparing external medicines for diabetic foot ulcer and bedsore, and can achieve integrated treatment of counteracting toxic substances and removing decay, dispersing blood stasis and promoting tissue regeneration, and astringing sores and closing up.