52 results about "Foot ulcers" patented technology

The present invention provides orthotic devices for use in managing the treatment and prevention of lower extremity injuries, including foot ulcers. In various aspects, the present invention provides foot-worn orthotics which provide for improved compliance monitoring, and methods of their manufacture and use.

A warming system, mounted to the foot of a bed, warms a person's lower extremities by directing air into the space between the mattress and overlaying blankets. A blower directs air into an elongated distribution chamber having many tiny exit apertures. The chamber is mounted at the foot of the bed, so that air exiting the apertures warms the person's feet. For maximum thermal transfer, the chamber is placed under the sheet and any blankets, but above the mattress cover and fitted sheet. The chamber may be implemented by a length of open cell foam, a hollow manifold with many punctures or other tiny distribution apertures, collapsible pocket, etc. While the person is lying on the bed beneath the blankets, with feet proximate the foot of the bed, the blower directs temperature-regulated air into the chamber and through the exit apertures, thereby warming the person's feet. A temperature regulator ensures a normothermic air temperature (or alternatively, hyperthermic air temperature.) Thus, the invention helps relieve or prevent "cold feet" by directing normothermic air at a person's lower extremities. Additionally, by applying heat to the feet and legs, the invention encourages blood flow by virtue of sympathetic vasodilation and local temperature-mediated vasodilation. The invention is also believed to prevent some leg and foot ulcers from forming by maintaining the lower extremity at a near normal temperature during sleep.

The present invention describes novel methods for using 9-deoxy-2′,9-α-methano-3-oxa-4,5,6-trinor-3,7-(1′,3′-interphenylene)-13,14-dihydro-prostaglandin F₁ (also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of foot ulcers in subjects with diabetic neuropathy. The invention also relates to kits for treatment and/or prevention of foot ulcers, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

The invention belongs to the technical field of new indications of drugs, and particularly discloses an application of externally used skin generation oil in preparation of drugs for preventing or treating diabetic peripheral circulation disturbance and foot ulcer. The externally used skin generation oil can effectively improve low temperature at soles due to peripheral circulation disturbance in early stage of diabetic foot ulcer, recover the sole pain threshold to a normal level, accelerate diabetic foot ulcer wound repair and shorten the wound repair time. The area of a foot ulcer wound surface of a diabetic rat is reduced to (4.0 plus or minus 0.1 mm<2>) from (51.3 plus or minus 3.5 mm<2>) after treated with the skin generation oil for 35 days, the wound surface heals basically, the skin is red and dry, and the skin surface is smooth; HE (hematoxylin-eosin) dyeing results show that the skin tissue structures of the foot wound surfaces of rats in an externally used skin generation oil group and an externally used skin generation oil and metformin group is relatively complete, collagen fibers at the wound edge are arranged in order, and inflammatory cell infiltration of wound surface tissue is reduced obviously.

This invention relates to methods of treating or preventing type 2 diabetes, diabetic neuropathy, diabetic cardiomyopathy, cataracts, diabetic retinopathy, foot ulcers, diabetic microangiopathy, diabetic macroangiopathy, diabetic ischemia reperfusion injury, diabetic cardiac ischemia reperfusion injury and/or insulin resistance syndrome (IRS) in mammals, particularly in humans, by administering a sodium-hydrogen exchanger type 1 (NHE-1) inhibitor or a pharmaceutical composition containing such an inhibitor. This invention also relates to combinations comprising NHE-1 inhibitors and a second pharmaceutical agent, said combinations being useful in treating type 2 diabetes, IRS, diabetic neuropathy, diabetic cardiomyopathy, cataracts, diabetic retinopathy, foot ulcers, diabetic ischemia reperfusion injury, diabetic cardiac ischemia reperfusion injury, diabetic microangiopathy and/or diabetic macroangiopathy.

The invention relates to a medicament for treating diabetic foot and deep ulcer. A conventional treatment method of the diabetic foot has certain curative effect at the moment, but causes long-term unhealing of foot ulcer due to foot paralysis, thus having poor effect. The medicament is prepared in the following steps: crushing naphthalene, borneol, pseudo-ginseng, musk and zinc oxide into fine powder in a proportion, and mixing. According to the medicament, harmful bacteria in deep focus can be killed in a short time, so that the root that various stubborn ulcers are hard to completely heal can be solved. The medicament is a medicament for treating diabetic food and deep ulcer with simple drugs, low cost and good curative effect.

The invention relates to the technical field of medical equipment and discloses a temperature monitor for a diabetic peripheral arterial disease and an implementation method for the temperature monitor. Four temperature sensors are separately arranged on insteps and among toes of left and right feet of a human body, and temperature signals of corresponding regions are converted into electric signals and are transmitted to a microprocessor; the electric signals of the four temperature sensors are converted into temperature values by the microprocessor, and whether detected temperature values meet a preset alarm threshold range or not is judged; and alarm signals are sent to an alarm when the temperature values do not meet the temperature threshold range. The temperature monitor for the diabetic peripheral arterial disease, disclosed by the invention, is relatively low in cost, small in size and simple and convenient in operation, self-monitoring by a sufferer is facilitated, early discovery and early treatment are facilitated, and further occurrence and development of foot region ulcer are avoided; and the condition that the alarm can emerge alarm prompt signals once a skin temperature of tip ends of lower limbs is not above 28 DEG C or not below 32 DEG C or a local temperature difference of corresponding regions of two parapodia is not smaller than 2.2 DEG C can be achieved.

The invention discloses tea polyphenol film agent and the preparation method thereof which are used for the treatment of chronic ulcer of skin. Tea polyphenol and vitamin B12are taken as the main component, and the film agent is produced by adding auxiliary materials of film forming material and plasticizer, etc. The preparation method comprises the following steps: the film forming material is soaked in water, heated and dissolved in a water bath at 30 to 80 DEG C, and filtered, the tea polyphenol, the vitamin B12, and the plasticizer are added into the filtrate in proportion, uniform mixing, air bubble removing, film coating, drying and parting cut are performed, and then the tea polyphenol film agent product is obtained. The film agent of the invention can be effectively used to treat diabetes foot ulcer, hansens disease ulcer and other chronic ulcers of skin, and also used to treat skin ulcer caused by burn and scald, can quicken the healing of ulcers, increase the scarfskin complete coverage percentage, the ulcers are uneasy to recur, the film agent is safe and non-toxic, and the cost is low.

The invention discloses new purpose of a human Keratiocyte growth factor 1 applied to treatment of foot ulcers and leg ulcers of diabetes. In the invention, the biological activity of proliferation of epithelial cells is promoted by using the specificity of the human Keratiocyte growth factor 1 to repair the damage of the epithelial, and the structural restoration of the foot ulcers and leg ulcers of diabetes promoted to achieve the treatment of the foot ulcers and leg ulcers of diabetes.

The invention discloses shoe customizing equipment suitable for a diabetic patient and a customizing method of the shoe customizing equipment. According to the technical scheme, the shoe customizing equipment suitable for the diabetic patient is characterized by comprising detection equipment and display equipment used for displaying the detection equipment, and the display equipment is in wireless communication connection with the detection equipment; a pressure sensing flat plate, an arc-shaped rail arranged above the pressure sensing flat plate and a camera arranged above the arc-shaped rail are arranged on the detection equipment, the camera can move along the arc-shaped rail, an opening is formed in the arc-shaped rail, a support used for supporting shanks is arranged at the opening,and an arc-shaped rod is arranged on the support. The shoe can provide extra depth and width, reduce foot friction, relieve foot pressure of a patient and correct the stress condition of the foot of the patient, so that the foot ulcer risk of each diabetic patient can be reduced by 80% or above, and great benefits can be brought to each diabetic patient.

The invention discloses a medical hydrogel non-porous moisture permeable film for wound healing. The medical hydrogel non-porous moisture permeable film comprises hydrogel (GelMA-g-NIPAAm) formed by methacrylic acid esterified gelatin-g-N-isopropyl acrylamide, copper-based MOF particles which are embedded into the hydrogel and form functionalized medical hydrogel with the hydrogel, and a non-porous vapor permeable barrier film or a film laminate prepared from a thermoplastic resin composition, wherein the surface of the non-porous vapor permeable barrier film or the film laminate is modified and connected to the medical hydrogel or the surface of the medical hydrogel. The medical hydrogel non-porous moisture permeable film has the advantages of high antibacterial property, good waterproofand vapor permeable properties, no adhesion and the like, and is suitable for common wounds, large-area burns, diabetic hand-foot ulcers and other difficult-to-heal wounds.

The invention relates to a method of treating a patient suffering from peripheral vascular disease, peripheral neuropathies, or autonomic neuropathies by administering a cGMP PDE5 inhibitor such as sildenafil. The method is particularly applicable to patients suffering from diabetic foot ulcers, Raynaud's Phenomenon, CREST Syndrome, erythromatosis, rheumatoid diseases, diabetic retinopathies and onychiomycosis. According to the present invention, a cGMP PDE5 inhibitor may be administered as a prophylactic to patients predisposed to develop a peripheral vascular disease, peripheral neuropathy or autonomic neuropathy.

Epidermal growth factor (EGF) produced by an excretory recombinant approach was tested for its efficacy in treating various skin wounds. In a randomized double blind controlled study, local cream samples prepared with human EGF at a final concentration of as low as 0.02% (g/g) in topically suitable carrier were found to have an enhancing effect on the recovery of diabetes foot ulcers. This promotional effect is statistically significant and has resulted in a reduced mean healing time of over 3 weeks when compared with that of control. Both the 0.02% (g/g) and 0.04% (g/g) human EGF supplemented samples in comparison with control showed a trend of stimulatory effect when a recovery of 50% of an ulcer was considered. The EGF samples were also shown to be highly effective in promoting treatments of wounds resulting from bedsores and surgeries.

The invention discloses a foamed emulsion for protecting the skin of foot of diabetes patients. The foamed emulsion is prepared from purified water, urea, glycerin, glyceride, coconut oil foaming agent, Anhui safflower extract, and sea cucumber extract, and is prepared by the following steps: mixing all raw materials mentioned above according to a certain ratio, stirring for 2 to 3 hours in a sterile environment at a temperature of 54 to 56 DEG C, and finally filling the mixed foamed emulsion into bottles. The traditional Chinese medicine and sea biological product are organically compounded; other components are added, so the foamed emulsion can effectively and conveniently protect the skin of foot of diabetes patients, kill bacteria and moulds on the foot, maintain the water of foot, and improve the blood circulation of skin, and thus the foot ulcer caused by diabetes is effectively reduced or even avoided.

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for diabetic foot ulcer, which is prepared from the following raw materials in parts by weight: 12 to 14 parts of catechu, 10 to 15 parts of honeysuckle flower, 8 to 10 parts of rhizoma coptidis, 5 to 9 parts of herba taraxaci, 6 to 10 parts of herba portulacae, 1to 3 parts of hydrargyri oxydum rubrum, 5 to 7 parts of radix scutellariae, 8 to 10 parts of fructus crataegi, 5 to 7 parts of frankincense and 5 to 9 parts of ginger. The traditional Chinese medicine composition obtained by the invention is used for treating foot ulcer caused by diabetes mellitus, and can effectively relieve foot ulcer and effectively prevent diabetic foot ulcer after being smeared on affected parts of feet of a patient.

The invention relates to a toe cover for preventing and treating foot ulcers, comprising an internal cylinder body (1), an external cylinder body (2) and artificial cotton and medicaments (3). The external cylinder body (2) is arranged outside the internal cylinder body (1); the artificial cotton and the medicaments (3) are filled between the internal cylinder body (1) and the external cylinder body (2); and the medicaments comprises the following components: 0.1 to 0.2 gram of sulfur, 0.1 to 0.2 gram of lightyellow sophora root and 0.1 to 0.2 gram of humifuse euphorbia herb. With respect to the materials, the internal cylinder body and the external cylinder body are made of cloth with air permeability, moisture absorption property and elasticity. For the complete set of technology, the design is artful, two technologies are organically combined and mutually promoted so as to hit the pathogenesis, and the treatment principle of combining treatment and nourishment, including dampness elimination, itch relief and sterilization, is fully embodied.