404 results about "Hydrogel matrix" patented technology

The invention discloses a reversible background-free hydrogel nanosensor for acetone detection and an intelligent sensing platform, and relates to the technical field of biosensors. The hydrogel nanosensor consists of a hydrogel matrix and an upconversion nanoprobe, and the upconversion nanoprobe comprises upconversion nanoparticles (UCNPs), hydroxylamine sulfate and thymol blue (TB). The invention adopts hydroxylamine sulfate as a specific recognition unit of acetone to construct a reversible luminescent hydrogel probe for acetone detection, and the probe can be reused in multiple detections, thereby reducing the cost of a single detection. In addition, by adopting near-infrared light as an excitation light source, the autofluorescence interference of the hydrogel matrix is ​​effectively avoided, thereby improving the detection accuracy.

The invention belongs to the technical field of biomedical materials, and relates to ultrasonic response adhesion integrated hydrogel as well as a preparation method and application thereof, the hydrogel comprises a hydrogel matrix, an interface anchoring agent and a functional load component; the preparation method comprises the following steps: 1, preparing a hydrogel precursor solution, and preparing a hydrogel matrix into a solution; 2, carrying out mold molding or injection crosslinking on the solution prepared in the step 1 to form hydrogel; 3, preparing an interface anchoring agent solution, and dissolving or dispersing an interface anchoring agent in a solvent to prepare the interface anchoring agent solution; the ultrasonic responsive adhesive hydrogel platform provided by the invention can provide an efficient, controllable and universal solution for tissue adhesion, targeted therapy, wearable attachment and the like in a complex microenvironment, and is suitable for a plurality of clinical scenes such as chronic wound management, surgical postoperative closure, infection control, adhesive bioelectronic fixation, soft tissue engineering and the like.

The invention provides an injectable short-fiber-based hydrogel tissue repair material with an electric response characteristic as well as a preparation method and application thereof, and the injectable short-fiber-based hydrogel tissue repair material with the electric response characteristic is prepared by taking a natural polymer material loaded with bioactive factors as a core layer material and a biodegradable material as a shell layer material through a coaxial electrostatic spinning technology. The method comprises the following steps: preparing short fibers with a core-shell structure, uniformly mixing the short fibers with a hydrogel matrix, injecting and filling a tissue defect part, and carrying out ultraviolet curing to form the tissue repair material. The injectable short-fiber-based hydrogel tissue repair material with the electrical response characteristic provided by the invention has piezoelectric characteristic and injectable characteristic, can generate electrical response through mechanical stimulation so as to promote cell proliferation and tissue repair, and also has controllable drug release capacity and good mechanical adaptability; the method is suitable for application scenes of complex tissue damage repair such as diabetes infected wound repair, articular cartilage repair, oral barrier membrane repair, abdominal wall defect repair and the like.

The invention belongs to the technical field of antibiosis and wound healing promotion, and relates to double-response (near-infrared light and hydrogen peroxide double-response photo-thermal / carbon monoxide therapy) antibacterial hydrogel as well as preparation and application thereof. The invention relates to a double-response antibacterial hydrogel. The antibacterial hydrogel is prepared from the following components: drug-loaded nano particles and a hydrogel matrix. The drug-loaded nano particles are prepared by loading dimanganese decacarbonyl (MnCO) into cavities of hollow mesoporous copper sulphide nano particles (HMCuS NPs) and coating the surfaces of the particles with a polydopamine layer (PDA). According to the invention, CO / PTT synergistic treatment of bacterial infected wounds is realized, and the antibacterial effect is significantly improved. An in-vitro antibacterial experiment result shows that the antibacterial hydrogel shows extremely strong inhibition capability on escherichia coli and staphylococcus aureus, and the problem of drug resistance caused by a bacterial biofilm is effectively solved.

The invention provides dual-response antibacterial repair-promoting injectable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. Two-dimensional titanium carbide (TiO2 (at) MXene) with the surface modified with titanium dioxide and a bioactive substance are introduced into a hydrogel matrix to serve as functional additives, TiO2 (at) MXene is a photo-thermal and ultrasonic response material, can emit heat under 808 nm near-infrared (NIR) light irradiation and low-intensity pulsed ultrasound (LIPUS) stimulation, and can generate reactive oxygen species (ROS) for sterilization under LIPUS stimulation; when the temperature of the hydrogel is increased, the bioactive substances can be slowly released from the hydrogel, and cell proliferation and tissue repair are promoted. The hydrogel provided by the invention can be coated on the surface of skin or injected under soft tissue, so that the functions of resisting bacteria in the early stage of inflammation and promoting tissue repair in the later stage are realized.

The invention discloses a method for constructing a multicellular living body material by adopting a droplet bioreactor, which belongs to the crossing field of biological materials and microbial engineering, and comprises the following steps: (1) resuspending different cells in different polymer solutions to prepare degradable or phase-separable hydrogel particles containing cells; (2) dispersing the hydrogel particles in a cross-linkable hydrogel matrix to form a composite hydrogel; and (3) curing the composite hydrogel, and then carrying out degradation treatment to obtain the liquid cavity structure multicellular system bioreactor with spatial partition and dynamic interaction characteristics. According to the invention, ordered distribution and metabolism synergy of different microorganisms in space can be realized, controllable degradability and excellent mass transfer performance are realized, bacterial slow release and metabolite exchange can be maintained, and the method is suitable for long-term stable operation of a continuous flow reactor. The method has wide application prospects in the fields of green biological manufacturing, renewable energy source production, environmental restoration, biomedical engineering and the like.

The invention belongs to the technical field of medical products, and provides a hydrogel dressing for diabetic chronic wounds and a preparation method and application of the hydrogel dressing. The antibacterial effect of the hydrogel dressing for the chronic wound surface of diabetes mellitus is improved by increasing the ZIF-8 coated AgNPs; in the hydrogel matrix part, the pH response is dominated by adjusting the component proportion of the temperature-sensitive agent N-isopropylacrylamide and the pH response 1-vinyl imidazole; the N-isopropylacrylamide assists the extension of a macromolecular chain segment in the composite hydrogel dressing, so that the dressing can fully absorb wound exudate and is easy to peel off, and secondary damage can be avoided.

The invention discloses bioactive macroporous hydrogel as well as a preparation method and application thereof. The bioactive macroporous hydrogel comprises hydrogel particles and a bioactive load loaded on the hydrogel particles, the hydrogel particles are obtained by mechanically extruding a hydrogel matrix, and the hydrogel matrix is formed by compounding sodium alginate, agarose and methacrylated hyaluronic acid through hydrogen bond crosslinking and photo-crosslinking; the bioactive load comprises: a) small extracellular vesicles of which the surfaces are modified with macrophage targeted CRV peptides; and b) a PLGA (poly (lactic-co-glycolic acid)) microsphere loaded with a cartilage inducer Kartogenin. The bioactive macroporous hydrogel disclosed by the invention has an internally communicated macroporous network, is beneficial to cell infiltration, blood vessel ingrowth and nutrient substance diffusion, and overcomes the defects that the traditional hydrogel is small in pore size and limits cell behaviors. According to the bioactive macroporous hydrogel disclosed by the invention, dual bioactive loads are adopted to synergistically promote tendon-bone healing, so that the treatment effect is better.

The invention discloses cinnamyl aldehyde at nano calcium carbonate / chitosan hydrogel. The hydrogel comprises a hydrogel matrix formed by cross-linking nano calcium carbonate and chitosan, and cinnamyl aldehyde loaded on the hydrogel matrix. The hydrogel system which is loaded with traditional Chinese medicine components and intelligently controls effective release of the traditional Chinese medicine components is prepared by utilizing the mutual adsorption effect of cinnamyl aldehyde and nano calcium carbonate. The hydrogel has excellent antibacterial activity and a function of accelerating wound healing, and the effect of the hydrogel is obviously superior to that of common calcium carbonate / chitosan hydrogel. A new direction is provided for application of the cinnamyl aldehyde and nano calcium carbonate / chitosan nano system, and a new strategy is provided for designing advanced functional materials modified by traditional Chinese medicine ingredients.

The invention provides a postoperative monitoring device based on an implant and a system thereof, which adopt an injectable, wireless and completely degradable ultrasonic sensor to realize real-time, continuous and non-invasive monitoring of a physiological environment (pressure, temperature and pH) around a metal internal fixture (such as a bone lamella and an intramedullary nail). The size of the sensor is 2 * 2 * 2mm < 3 >, and the sensor adopts a dual-network hydrogel matrix and a periodically arranged air column structure, is implanted into a body in a minimally invasive manner, and is naturally degraded within 4-5 weeks after an operation. The system further comprises a data processing unit and a user interface which are used for displaying monitoring data and early warning information. According to the method, the limitation of a traditional monitoring method is overcome, the monitoring accuracy and reliability are improved, the medical cost and the pain of a patient are reduced, and the method has wide clinical application prospects and social and economic values.

The invention relates to a 4D printing hydrogel material and a preparation method and application thereof, and belongs to the technical field of hydrogel materials.The preparation method of the 4D printing hydrogel material comprises the steps that S1, N-isopropylacrylamide is subjected to a prepolymerization reaction under the action of a photoinitiator, and a prepolymer is obtained; s2, the prepolymer, [2-(methylacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide and a cross-linking agent are mixed, and printing slurry is obtained; s3, carrying out 3D photocuring printing by adopting the printing slurry to obtain a hydrogel matrix with a porous structure; and S4, soaking the hydrogel matrix in a lithium salt solution to obtain the 4D printing hydrogel material. The 4D printing hydrogel material provided by the invention can generate a volume swelling phenomenon in a moisture absorption process, has rapid moisture absorption dynamics and ultrahigh moisture absorption capacity, and has excellent moisture storage and water collection capacities.

The invention relates to the technical field of biomedical materials, in particular to engineered small extracellular vesicle hydrogel enriched with PD-L1 and Siglec-15 as well as a preparation method and application of the engineered small extracellular vesicle hydrogel. The engineering small extracellular vesicle hydrogel is enriched with PD-L1 and Siglec-15 at the same time, the engineering small extracellular vesicle hydrogel comprises a hydrogel base body and PDL1-Siglec15-sEVs loaded in the hydrogel base body, and the PDL1-Siglec15-sEVs are small extracellular vesicles with the PD-L1 and the Siglec-15 in an overexpression mode. Compared with natural small extracellular vesicles and a traditional wound surface treatment strategy, the engineered small extracellular vesicle hydrogel has the advantages that PD-L1 and Siglec-15 can be enriched in the vesicles, so that more accurate immune microenvironment regulation and control can be realized on the local part of a wound surface, excessive inflammatory response is moderately inhibited, phenotype transformation of macrophages to be beneficial to tissue regeneration is promoted, and the wound surface treatment effect is improved. The hydrogel is used as a carrier and can provide a moist healing environment and a three-dimensional scaffold structure, so that the residence time of the engineered small extracellular vesicles on the local wound surface is remarkably prolonged, and slow release is realized.

The invention relates to the technical field of fluorescent hydrogel, in particular to high-strength and high-stability fluorescent hydrogel as well as a preparation method and application thereof, the fluorescent hydrogel is formed by physical crosslinking of a hydrogel matrix, a rare earth fluorescent complex and a stabilizer, the hydrogel matrix is of a double-network structure formed by physical crosslinking of polyvinyl alcohol and carboxymethyl cellulose; the rare earth fluorescent complex is formed by connecting rare earth metal ions and an organic antenna material through coordination; the stabilizer is trisodium citrate. Compared with other fluorescent hydrogel, the fluorescent hydrogel with high strength and high stability provided by the invention has the advantages that the phenomena of fluorescence decay and fluorescence quenching caused by metal ions and saturated salt solution are avoided, and the fluorescence is kept stable in a wide pH range. Because the fluorescence characteristic is not influenced by environmental corrosion factors, the information can be stably displayed for a long time, and the method can be used for information encryption and anti-counterfeiting in an extreme environment.

The invention relates to the technical field of functional food and biological medicine, in particular to a modified pseudo-ginseng exosome and an intestinal conditioning gel composition and application thereof. According to the gel beverage, an exosome derived from panax notoginseng callus cultured in a laboratory is used as a core active component, is modified through phosphatidylserine-aminated pectin-genipin and is embedded into a hydrogel matrix composed of carboxymethyl chitosan and sodium alginate, so that the exosome is protected from being degraded in the stomach, and the activity of the exosome in the stomach is improved. The exosome can be effectively released under the intestinal pH and flora environment, so that the targeted delivery of the intestinal tract is realized, and the preparation method is suitable for improving the intestinal inflammation and maintaining the intestinal health. The invention can effectively solve the technical problems of uncontrollable raw material quality and safety, low oral delivery stability and active ingredient availability and poor medication compliance of the existing plant exosome.

The invention relates to the field of skincare products, and particularly discloses skincare gel loaded with ganoderma lucidum exosome and a preparation method of the skincare gel. The skin care gel loaded with the lucid ganoderma exosome is prepared from the following raw materials in parts by weight: 20 to 40 parts of hydrogel matrix, 2 to 4 parts of lucid ganoderma exosome nanoparticles, 2 to 6 parts of niobium carbide nanosheets, 1 to 3 parts of nicotinamide, 0.1 to 2 parts of phenethyl resorcinol and 0.1 to 3 parts of green tea extract, the Mailing exosome nanoparticles are of a core-shell structure, a core layer comprises Mailing exosome and papain in a mass ratio of 1: (0.1-0.2), and a shell layer comprises a polylactic acid-glycolic acid copolymer and a penetration enhancer in a mass ratio of 1: (0.1-0.3). The skin-care gel provided by the invention has remarkable whitening, moisturizing and skin brightening effects.

The invention discloses composite hydrogel as well as a preparation method and application thereof. The composite hydrogel comprises a hydrogel matrix and a liposome loaded on the hydrogel matrix, the hydrogel matrix comprises a methacrylated natural protein, and the liposome is loaded with a drug; the medicine comprises a medicine for promoting cartilage differentiation and an anti-inflammatory traditional Chinese medicine monomer. According to the invention, through a liposome entrapment technology, the stability and sustained release ability of the insoluble traditional Chinese medicine monomer and the cartilage differentiation induction drug are enhanced. The particle size of the liposome is controllable, the liposome is well combined with a methacrylated natural protein network, a drug sustained release bin can be formed in the hydrogel, long-time and local precise release is achieved, the drug utilization efficiency is improved, and systematic toxic and side effects are avoided.

The invention discloses a nano-enzyme microneedle system for remodeling a diabetes wound microenvironment to promote healing and a preparation method of the nano-enzyme microneedle system. The nano-enzyme microneedle system comprises nano-enzyme and a microneedle carrier, the nano-enzyme is prepared by a self-assembly method and is loaded in the microneedle carrier; the microneedle carrier is composed of a hydrogel matrix and is molded into a microneedle array through 3D printing; according to the system, the nano-enzyme can be delivered to the corium layer by penetrating the cuticle of the skin through the microneedle. The traditional Chinese medicine composition has the advantages that ROS (reactive oxygen species) is efficiently removed, oxidative stress injury induced by high glucose (HG) is relieved, immune cell polarization is regulated, inflammatory factor release is regulated and controlled, the chronic inflammation state of wound surfaces is relieved, cell proliferation and migration are promoted, neovascularization is accelerated, the healing speed of the diabetic wound surfaces is obviously increased, inflammation infiltration is reduced, granulation tissue formation and collagen deposition are obviously improved, and the effect of treating diabetes mellitus is achieved. And no systemic toxicity is observed. Through the synergistic effect of resisting oxidation, resisting inflammation and promoting angiogenesis, the pathological microenvironment of the diabetic wound is effectively improved.

The invention discloses composite hydrogel with a photo-thermal antibacterial effect and a preparation method of the composite hydrogel. The composite hydrogel is prepared from the following components: gold nanorods with a photo-thermal effect; silver nanoparticles grow on the surface of a gold nanorod through a reduction deposition method, and a silver-coated gold nanorod of a core-shell structure is formed; oxidized hyaluronic acid and carboxymethyl chitosan are subjected to Schiff base reaction and cross-linking to form a self-healing hydrogel matrix; the advantages of the Au-Ag-PEG nanoparticles and the hydrogel are combined, so that the Au-Ag-PEG hydrogel has an excellent antibacterial effect in vitro and in vivo; therefore, the nano composite hydrogel wound dressing has huge application potential in the aspect of treating infectious skin wounds.

The invention relates to the technical field of photonic crystal materials, in particular to a wide-temperature-range low-energy-consumption multistable photonic crystal film and a preparation method and application thereof.The photonic crystal film is composed of a physical crosslinking type hydrogel matrix and magnetic response type photonic crystals fixed in the physical crosslinking type hydrogel matrix, the photonic crystal film has magnetic field adjustability of colors in a sol state above a phase change point of the hydrogel, and magnetic assembly colors in the sol state can be recorded and developed in a gel state at the temperature of the phase change point. According to the wide-temperature-range low-energy-consumption multistable photonic crystal film, the element for regulating and controlling the optical property is the magnetic photonic crystal, the color is changed based on magnetic field response, compared with other external fields such as light, electricity and chemical stimulation, the magnetic field has the properties of non-contact, controllability and the like, and adjustment is easy and convenient. The photonic crystal film is rich in color change variety, energy loss only occurs in the color regulation and control stage, color stable display does not need external field assistance, and therefore the photonic crystal film is a low-energy-consumption multistable photonic crystal film.

The invention provides a preparation method of an insecticide synergistic responsive release delivery system, and belongs to the technical field of insecticides. Chlorantraniliprole insecticide is dissolved in an acetone solvent containing Tween 80 to form a drug-carrier complex; then polymerizing the N-isopropylacrylamide temperature-sensitive monomer under the action of an ammonium persulfate and tetramethylethylenediamine initiation system to form a temperature-responsive hydrogel matrix; four key parameters including the optimal molar ratio, the optimal embedding temperature, the optimal embedding time and the optimal phase change temperature control precision of an amido hydrophilic group and an isopropyl hydrophobic group are calculated by applying a double-layer game model, and a drug-carrier complex is embedded into a hydrogel matrix through a physical embedding effect to construct a three-layer nested delivery structure; the technical problem that the pesticide effect utilization rate is low due to the fact that the pesticide lacks an accurate temperature-responsive release control mechanism in environmental application is solved.

The invention relates to the technical field of drug-loaded microparticles, in particular to a preparation method and application of medical stone / PLGA composite drug-loaded microparticles, medical stone and PLGA are prepared into a structure with activated nano medical stone as a core and a PLGA polymer as a shell through the processes of ball milling, acid activation, emulsification, solvent volatilization and the like, and the medical stone and the PLGA are synergistically matched, so that the drug-loaded microparticles have the advantages that the drug-loaded microparticles are uniform in particle size distribution, and the drug-loaded microparticles have good drug-loaded performance. Firstly, the hydrogel has intelligent responsiveness, can accelerate degradation in alkaline and enzyme environments of wound surfaces, and realizes accurate release of drugs as required; secondly, the long-acting controlled release property is shown, and a dual sustained release barrier is constructed through medical stone adsorption and PLGA wrapping, so that the medicine is released for more than 72 hours at a constant speed following zero-order dynamics, and burst release is effectively avoided. And thirdly, when the drug-loaded particles are used for hydrogel, the drug-loaded particles in nanoscale are combined with the hydration effect of a hydrogel matrix, so that the efficient permeability of the drug in the cuticle is greatly improved.

The invention relates to a myocardial tissue construct with a bionic structure and a function as well as a preparation method and application of the myocardial tissue construct. The myocardial tissue construct with both the bionic structure and the function comprises the following components: a hydrogel matrix suitable for 3D printing rheological properties, a cross-linking agent dispersed in the hydrogel matrix, inorganic biological material particles with myocardial protection and vascularization biological activity promotion, myocardial cells and vascularization related cells, the myocardial cells and the vascularization-related cells are regularly arranged in a three-dimensional space by simulating a cell distribution mode in a natural myocardial tissue; preferably, the regularly arranged structure comprises at least one of spatial arrangement of myocardial cell-angiogenesis related cells in a left-right / up-down side-by-side mode and spatial arrangement of myocardial cell-angiogenesis related cells in a core-shell / shell-core coaxial mode.

The invention provides a sunlight-excited multi-ROS (reactive oxygen species) response oxygen sensitization type hydrogel. The sunlight-excited multi-ROS response oxygen sensitization type hydrogel is prepared from a plant-derived nano capsule-like body (NT), an AQPP liposome (AL) and pluronic F127 serving as a hydrogel matrix. The invention also provides a preparation method of the hydrogel and application of the hydrogel in preparation of medicines for treating skin ulcers. The NTALG causes bacterial membrane function damage after illumination, has a strong antibacterial effect and can promote healing of diabetic wounds.

The invention relates to the technical field of biological medicines, and provides functional hydrogel for promoting hair follicle regeneration as well as a preparation method and application of the functional hydrogel. The functional hydrogel comprises a hydrogel matrix and an SHP2 inhibitor SHP099 carried on the hydrogel matrix. The invention further provides a corresponding preparation method and application in preparation of dressing for treating scar wound surfaces. The functional hydrogel constructed by the invention is used as a powerful tool for researching the formation of a dermis shell, not only plays a huge role in the fundamental research of the formation of skin appendages in the future, but also has a wide market application prospect in the aspects of wound healing promotion and hair follicle regeneration promotion dressings.

The invention provides a hydrogel-based radiation refrigeration moisture power generation material and a preparation method and application thereof, and belongs to the technical field of moisture power generation materials.The hydrogel-based radiation refrigeration moisture power generation material comprises a nano carbon black layer, a conductive hydrogel layer and a titanium dioxide layer which are sequentially stacked; the conductive hydrogel layer comprises a hydrogel matrix, a conductive filler and a temperature-sensitive material; the temperature-sensitive material comprises at least one of poly (N-isopropylacrylamide), a polyethylene glycol and polylactic acid copolymer and vanadium oxide; the cross section of the hydrogel-based radiation refrigeration moisture power generation material is of a W-shaped structure. The conductive hydrogel layer is of a three-dimensional network structure with conductivity and temperature-sensitive characteristics; the titanium dioxide layer realizes efficient sunlight reflection, the nano carbon black layer enhances heat conduction and conductivity, and the W-shaped structure promotes moisture flow and circulation; the multifunctional power generation device prepared based on the hydrogel-based radiation refrigeration moisture power generation material has good radiation refrigeration and moisture power generation performance, and is excellent in stability and durability.

The invention discloses a mechanical response type engineered mesenchymal stem cell exosome preparation for treating diseases caused by fibrosis inflammation, a preparation method and application, and the exosome preparation is an exosome which is secreted by mesenchymal stem cells and has high cholesterol and high-efficacy protein. The exosome is prepared by culturing mesenchymal stem cells on a hydrogel matrix in a modulus hardness range of 1-50KPa, the exosome secretion amount of a single cell is (3-5) * 10 < 4 > / cell, the cholesterol content is (1-10) nM / 5mg exosome, and the size of the exosome is 110-140nm; the high-efficacy protein is a key functional protein for regulating and controlling the biological activity of the exosome and the cell action efficiency. The cholesterol content in the exosome is precisely regulated and controlled, the cytoplasm delivery efficiency and tissue penetrability of the exosome are improved, a whole-process control system of hydrogel preparation, stem cell culture and exosome purification is constructed, and the stability of the preparation and the yield of the exosome are improved.

The invention belongs to the technical field of conductive hydrogel composite materials, and relates to nanofiber reinforced composite organic hydrogel as well as a preparation method and application thereof.The method comprises the following preparation steps: synthesizing a thermoplastic polyurethane (TPU) nanofiber membrane in advance, uniformly filling a TPU stretchable matrix with carbon nanotubes (CNTs) in a solvent by adopting ultrasonic assistance, and preparing the nanofiber reinforced composite organic hydrogel. A conductive network is adjusted by adjusting the loading capacity of carbon nanotubes on a fiber membrane through different ultrasonic time, and the upper layer and the lower layer of the modified fiber membrane are coated with a polyvinyl alcohol / glycerol / aqueous solution to prepare a conductive CNTs (at) TPU-X nanofiber membrane (x is ultrasonic time), so that the elastomer film sensor with a sandwich-like structure is obtained. According to the invention, the problems of dispersibility of the nanofiller in a hydrogel matrix and interfacial compatibility of fibers and gel are solved.

The present invention discloses an intelligent, bioengineered wound dressing device that utilizes honey bee-derived therapeutic compounds integrated into a programmable, multi-layered delivery structure designed for sustained antimicrobial release and dynamic wound healing modulation. The device features microencapsulated honey, propolis, and beeswax components embedded within a biocompatible hydrogel matrix, supported by a control technique that processes real-time wound data acquired through embedded biosensors. The technique classifies healing phases, detects wound anomalies, and modulates therapeutic release through actuators based on environmental cues such as pH, temperature, and exudate levels. The system further includes a logic control unit capable of adaptive learning, remote data transmission, and wound trajectory logging, ensuring precise, patient-specific therapeutic delivery. By integrating natural antimicrobial agents with intelligent sensing and release architectures, the invention provides a responsive, self-optimizing wound care platform that enhances healing outcomes, reduces dressing intervention frequency, and improves clinical oversight through real-time therapeutic intelligence.

The invention relates to the technical field of burn and scald treatment, in particular to an intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release. The dressing comprises a core-shell microsphere drug loading system used for realizing physical segmentation of a functional area; the dual-release system is used for realizing surface adsorption of quick-release drug nanoparticles and internal wrapping of sustained-release microspheres; a hydrogel matrix for forming a nanofiber network; and the magnetic control regulator is magnetic nanoparticles dispersed in the hydrogel matrix, and regulates the aperture of the hydrogel network through the action of an external magnetic field. According to the intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release, the Mongolian medicine compound intelligent hydrogel dressing is developed on the basis of a TRIZ innovative method; through a core-shell microsphere drug loading system and a dual release design, high drug loading capacity and accurate drug release control are synchronously realized.

The invention provides hydrogel, preparation of the hydrogel and medical dressing containing the hydrogel, CMC-PBA and HA-DA are used as hydrogel matrixes and are connected through boric acid ester bonds, and copper nano-enzyme (Cu NCs) chelated by EGCG is added into the hydrogel matrixes, so that the hydrogel (EGCG-Cu NPs) loaded with the copper nano-enzyme (injectable) is obtained. Wherein the CMC-PBA is a product obtained by reacting carboxymethyl chitosan (CMC) with carboxyl activated 4-carboxyphenylboronic acid (PBA), and the HA-DA is a product obtained by reacting carboxyl activated hyaluronic acid (HA) with dopamine hydrochloride (DA). The hydrogel can deeply promote wound recovery through in-vivo use, has good antioxidant activity and antibacterial activity, has extremely high active oxygen removal performance on necrotic cells of the wound, greatly accelerates the healing speed of the wound, brings clinical welfare to the wound, especially a chronic disease wound, and promotes the development of chronic wound diseases.