256 results about "Hydrogel matrix" patented technology

The invention belongs to the technical field of antibiosis and wound healing promotion, and relates to double-response (near-infrared light and hydrogen peroxide double-response photo-thermal / carbon monoxide therapy) antibacterial hydrogel as well as preparation and application thereof. The invention relates to a double-response antibacterial hydrogel. The antibacterial hydrogel is prepared from the following components: drug-loaded nano particles and a hydrogel matrix. The drug-loaded nano particles are prepared by loading dimanganese decacarbonyl (MnCO) into cavities of hollow mesoporous copper sulphide nano particles (HMCuS NPs) and coating the surfaces of the particles with a polydopamine layer (PDA). According to the invention, CO / PTT synergistic treatment of bacterial infected wounds is realized, and the antibacterial effect is significantly improved. An in-vitro antibacterial experiment result shows that the antibacterial hydrogel shows extremely strong inhibition capability on escherichia coli and staphylococcus aureus, and the problem of drug resistance caused by a bacterial biofilm is effectively solved.

The invention discloses a method for constructing a multicellular living body material by adopting a droplet bioreactor, which belongs to the crossing field of biological materials and microbial engineering, and comprises the following steps: (1) resuspending different cells in different polymer solutions to prepare degradable or phase-separable hydrogel particles containing cells; (2) dispersing the hydrogel particles in a cross-linkable hydrogel matrix to form a composite hydrogel; and (3) curing the composite hydrogel, and then carrying out degradation treatment to obtain the liquid cavity structure multicellular system bioreactor with spatial partition and dynamic interaction characteristics. According to the invention, ordered distribution and metabolism synergy of different microorganisms in space can be realized, controllable degradability and excellent mass transfer performance are realized, bacterial slow release and metabolite exchange can be maintained, and the method is suitable for long-term stable operation of a continuous flow reactor. The method has wide application prospects in the fields of green biological manufacturing, renewable energy source production, environmental restoration, biomedical engineering and the like.

The invention relates to the technical field of biomedical materials, in particular to engineered small extracellular vesicle hydrogel enriched with PD-L1 and Siglec-15 as well as a preparation method and application of the engineered small extracellular vesicle hydrogel. The engineering small extracellular vesicle hydrogel is enriched with PD-L1 and Siglec-15 at the same time, the engineering small extracellular vesicle hydrogel comprises a hydrogel base body and PDL1-Siglec15-sEVs loaded in the hydrogel base body, and the PDL1-Siglec15-sEVs are small extracellular vesicles with the PD-L1 and the Siglec-15 in an overexpression mode. Compared with natural small extracellular vesicles and a traditional wound surface treatment strategy, the engineered small extracellular vesicle hydrogel has the advantages that PD-L1 and Siglec-15 can be enriched in the vesicles, so that more accurate immune microenvironment regulation and control can be realized on the local part of a wound surface, excessive inflammatory response is moderately inhibited, phenotype transformation of macrophages to be beneficial to tissue regeneration is promoted, and the wound surface treatment effect is improved. The hydrogel is used as a carrier and can provide a moist healing environment and a three-dimensional scaffold structure, so that the residence time of the engineered small extracellular vesicles on the local wound surface is remarkably prolonged, and slow release is realized.

The invention relates to the technical field of fluorescent hydrogel, in particular to high-strength and high-stability fluorescent hydrogel as well as a preparation method and application thereof, the fluorescent hydrogel is formed by physical crosslinking of a hydrogel matrix, a rare earth fluorescent complex and a stabilizer, the hydrogel matrix is of a double-network structure formed by physical crosslinking of polyvinyl alcohol and carboxymethyl cellulose; the rare earth fluorescent complex is formed by connecting rare earth metal ions and an organic antenna material through coordination; the stabilizer is trisodium citrate. Compared with other fluorescent hydrogel, the fluorescent hydrogel with high strength and high stability provided by the invention has the advantages that the phenomena of fluorescence decay and fluorescence quenching caused by metal ions and saturated salt solution are avoided, and the fluorescence is kept stable in a wide pH range. Because the fluorescence characteristic is not influenced by environmental corrosion factors, the information can be stably displayed for a long time, and the method can be used for information encryption and anti-counterfeiting in an extreme environment.

The invention relates to the technical field of functional food and biological medicine, in particular to a modified pseudo-ginseng exosome and an intestinal conditioning gel composition and application thereof. According to the gel beverage, an exosome derived from panax notoginseng callus cultured in a laboratory is used as a core active component, is modified through phosphatidylserine-aminated pectin-genipin and is embedded into a hydrogel matrix composed of carboxymethyl chitosan and sodium alginate, so that the exosome is protected from being degraded in the stomach, and the activity of the exosome in the stomach is improved. The exosome can be effectively released under the intestinal pH and flora environment, so that the targeted delivery of the intestinal tract is realized, and the preparation method is suitable for improving the intestinal inflammation and maintaining the intestinal health. The invention can effectively solve the technical problems of uncontrollable raw material quality and safety, low oral delivery stability and active ingredient availability and poor medication compliance of the existing plant exosome.

The invention discloses a nano-enzyme microneedle system for remodeling a diabetes wound microenvironment to promote healing and a preparation method of the nano-enzyme microneedle system. The nano-enzyme microneedle system comprises nano-enzyme and a microneedle carrier, the nano-enzyme is prepared by a self-assembly method and is loaded in the microneedle carrier; the microneedle carrier is composed of a hydrogel matrix and is molded into a microneedle array through 3D printing; according to the system, the nano-enzyme can be delivered to the corium layer by penetrating the cuticle of the skin through the microneedle. The traditional Chinese medicine composition has the advantages that ROS (reactive oxygen species) is efficiently removed, oxidative stress injury induced by high glucose (HG) is relieved, immune cell polarization is regulated, inflammatory factor release is regulated and controlled, the chronic inflammation state of wound surfaces is relieved, cell proliferation and migration are promoted, neovascularization is accelerated, the healing speed of the diabetic wound surfaces is obviously increased, inflammation infiltration is reduced, granulation tissue formation and collagen deposition are obviously improved, and the effect of treating diabetes mellitus is achieved. And no systemic toxicity is observed. Through the synergistic effect of resisting oxidation, resisting inflammation and promoting angiogenesis, the pathological microenvironment of the diabetic wound is effectively improved.

The invention relates to the technical field of drug-loaded microparticles, in particular to a preparation method and application of medical stone / PLGA composite drug-loaded microparticles, medical stone and PLGA are prepared into a structure with activated nano medical stone as a core and a PLGA polymer as a shell through the processes of ball milling, acid activation, emulsification, solvent volatilization and the like, and the medical stone and the PLGA are synergistically matched, so that the drug-loaded microparticles have the advantages that the drug-loaded microparticles are uniform in particle size distribution, and the drug-loaded microparticles have good drug-loaded performance. Firstly, the hydrogel has intelligent responsiveness, can accelerate degradation in alkaline and enzyme environments of wound surfaces, and realizes accurate release of drugs as required; secondly, the long-acting controlled release property is shown, and a dual sustained release barrier is constructed through medical stone adsorption and PLGA wrapping, so that the medicine is released for more than 72 hours at a constant speed following zero-order dynamics, and burst release is effectively avoided. And thirdly, when the drug-loaded particles are used for hydrogel, the drug-loaded particles in nanoscale are combined with the hydration effect of a hydrogel matrix, so that the efficient permeability of the drug in the cuticle is greatly improved.

The invention provides a sunlight-excited multi-ROS (reactive oxygen species) response oxygen sensitization type hydrogel. The sunlight-excited multi-ROS response oxygen sensitization type hydrogel is prepared from a plant-derived nano capsule-like body (NT), an AQPP liposome (AL) and pluronic F127 serving as a hydrogel matrix. The invention also provides a preparation method of the hydrogel and application of the hydrogel in preparation of medicines for treating skin ulcers. The NTALG causes bacterial membrane function damage after illumination, has a strong antibacterial effect and can promote healing of diabetic wounds.

The invention provides a hydrogel-based radiation refrigeration moisture power generation material and a preparation method and application thereof, and belongs to the technical field of moisture power generation materials.The hydrogel-based radiation refrigeration moisture power generation material comprises a nano carbon black layer, a conductive hydrogel layer and a titanium dioxide layer which are sequentially stacked; the conductive hydrogel layer comprises a hydrogel matrix, a conductive filler and a temperature-sensitive material; the temperature-sensitive material comprises at least one of poly (N-isopropylacrylamide), a polyethylene glycol and polylactic acid copolymer and vanadium oxide; the cross section of the hydrogel-based radiation refrigeration moisture power generation material is of a W-shaped structure. The conductive hydrogel layer is of a three-dimensional network structure with conductivity and temperature-sensitive characteristics; the titanium dioxide layer realizes efficient sunlight reflection, the nano carbon black layer enhances heat conduction and conductivity, and the W-shaped structure promotes moisture flow and circulation; the multifunctional power generation device prepared based on the hydrogel-based radiation refrigeration moisture power generation material has good radiation refrigeration and moisture power generation performance, and is excellent in stability and durability.

The invention discloses a mechanical response type engineered mesenchymal stem cell exosome preparation for treating diseases caused by fibrosis inflammation, a preparation method and application, and the exosome preparation is an exosome which is secreted by mesenchymal stem cells and has high cholesterol and high-efficacy protein. The exosome is prepared by culturing mesenchymal stem cells on a hydrogel matrix in a modulus hardness range of 1-50KPa, the exosome secretion amount of a single cell is (3-5) * 10 < 4 > / cell, the cholesterol content is (1-10) nM / 5mg exosome, and the size of the exosome is 110-140nm; the high-efficacy protein is a key functional protein for regulating and controlling the biological activity of the exosome and the cell action efficiency. The cholesterol content in the exosome is precisely regulated and controlled, the cytoplasm delivery efficiency and tissue penetrability of the exosome are improved, a whole-process control system of hydrogel preparation, stem cell culture and exosome purification is constructed, and the stability of the preparation and the yield of the exosome are improved.

The invention belongs to the technical field of conductive hydrogel composite materials, and relates to nanofiber reinforced composite organic hydrogel as well as a preparation method and application thereof.The method comprises the following preparation steps: synthesizing a thermoplastic polyurethane (TPU) nanofiber membrane in advance, uniformly filling a TPU stretchable matrix with carbon nanotubes (CNTs) in a solvent by adopting ultrasonic assistance, and preparing the nanofiber reinforced composite organic hydrogel. A conductive network is adjusted by adjusting the loading capacity of carbon nanotubes on a fiber membrane through different ultrasonic time, and the upper layer and the lower layer of the modified fiber membrane are coated with a polyvinyl alcohol / glycerol / aqueous solution to prepare a conductive CNTs (at) TPU-X nanofiber membrane (x is ultrasonic time), so that the elastomer film sensor with a sandwich-like structure is obtained. According to the invention, the problems of dispersibility of the nanofiller in a hydrogel matrix and interfacial compatibility of fibers and gel are solved.

The invention relates to the technical field of burn and scald treatment, in particular to an intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release. The dressing comprises a core-shell microsphere drug loading system used for realizing physical segmentation of a functional area; the dual-release system is used for realizing surface adsorption of quick-release drug nanoparticles and internal wrapping of sustained-release microspheres; a hydrogel matrix for forming a nanofiber network; and the magnetic control regulator is magnetic nanoparticles dispersed in the hydrogel matrix, and regulates the aperture of the hydrogel network through the action of an external magnetic field. According to the intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release, the Mongolian medicine compound intelligent hydrogel dressing is developed on the basis of a TRIZ innovative method; through a core-shell microsphere drug loading system and a dual release design, high drug loading capacity and accurate drug release control are synchronously realized.

The invention discloses MoSe2 nano-enzyme-selenium-rich probiotic composite hydrogel and a preparation method and application thereof, the composite hydrogel comprises a hydrogel matrix and functional components dispersed in the hydrogel matrix, and the functional components comprise anti-MoSe2 nano-enzyme and selenium-rich probiotics wrapped by an antioxidant film. According to the MoSe2 nano-enzyme-selenium-enriched probiotic composite hydrogel provided by the invention, the sonodynamic characteristics of the MoSe2 nano-enzyme and the biological activity of the selenium-enriched probiotics are perfectly fused: under ultrasonic stimulation, the MoSe2 nano-enzyme not only can directly and efficiently generate reactive oxygen species (ROS), but also can catalyze low-concentration hydrogen peroxide to generate a large amount of hydroxyl radicals (. OH); broad-spectrum killing of various pathogenic bacteria is achieved, and the risk of drug resistance evolution of bacteria is reduced from the source; meanwhile, antibiotics secreted by the selenium-enriched probiotics can form a synergistic sterilization effect, so that the pathogenic bacterium removal effect is further enhanced.

This invention discloses a composite microsphere loaded with ZIF-8 nanoparticles and stem cell extracellular vesicles, its preparation method, and its applications. The composite microsphere comprises a hydrogel matrix microsphere, and ZIF-8 nanoparticles and small extracellular vesicles derived from bone marrow mesenchymal stem cells uniformly dispersed and encapsulated within the hydrogel matrix microsphere. This invention integrates ZIF-8 nanoparticles and stem cell-derived sEVs into injectable, photocurable GelMA microspheres, constructing an integrated delivery platform capable of sequential release and multi-stage synergistic effects. This platform successfully integrates and leverages three major functions: immunomodulation, stem cell recruitment, and cartilage-induced differentiation, ultimately achieving high-quality functional healing of the tendon-bone interface at both histological and biomechanical levels, providing a highly promising new strategy for the regeneration and repair of interfacial tissues in the musculoskeletal system.

The invention provides anisotropic thermoelectric hydrogel, which is characterized in that hydrogel is used as a matrix, and a thermoelectric material is dispersed and fixed in the hydrogel matrix; the hydrogel matrix is formed by biocompatible macromolecules through a directional freezing method or a mechanical stretching method, and has an anisotropic internal microstructure oriented in a single direction. Through a directional freezing or mechanical stretching process, a microstructure oriented in a single direction is constructed in the thermoelectric hydrogel, so that the hydrogel has anisotropy of shrinkage characteristics. The two preparation methods disclosed by the invention are both based on physical crosslinking and orientation technologies, complex chemical modification or expensive equipment is not needed, and effective design of the shrinkage anisotropy of the material is realized by controlling freezing conditions (such as liquid level height and cooling direction) or stretching parameters (such as stretching ratio and cycle index); and mutual conversion between heat energy and electric energy can be realized through a thermoelectric material in the hydrogel network.

The invention discloses a preparation method of intelligent response hydrogel for programmed delivery of hypoxia endogenous stem cell vesicles and application of the intelligent response hydrogel in promotion of postoperative peritoneum non-adhesion healing. The hydrogel is formed by crosslinking a first component, namely gallic acid modified chitosan loaded with hypoxia energizing stem cell vesicles, and a second component, namely aminophenylboronic acid grafted oxidized hyaluronic acid, and a double-network structure is constructed through a phenylboronic acid ester bond and a dynamic covalent imine bond. The hypoxia energizing stem cell vesicles cooperate with the hydrogel matrix to promote polarization of macrophages to an anti-inflammatory repair phenotype, and peritoneum repair is promoted. Phenylboronic acid ester bonds in the hydrogel respond to high active oxygen level programmed delivery of the hypoxia energizing stem cell vesicles in a postoperative injury area to form material response and biological intervention synergy, so that the problem that the stem cell vesicles are difficult to accurately regulate and control adhesion forming key links is solved; and a comprehensive solution with physical barrier and tissue repair functions is provided for postoperative peritoneum non-adhesion healing.

A composite material is provided. The composite material includes a hydrogel matrix having a three-dimensional geometry and fibers embedded and substantially uniformly distributed within the three-dimensional hydrogel matrix. The fibers have a substantially circular cross-sectional geometry and are anisotropically aligned. Methods of making and using the composite material are also provided.

The invention discloses a preparation method of polyvinyl alcohol / polyaniline / carbon nanotube composite hydrogel based on a dodecylbenzene sulfonic acid molecular bridge, and relates to the technical field of polymer composite materials and energy storage devices. The invention innovatively provides a'molecular bridge 'strategy, and a highly stable interface structure between PANI and CNTs is constructed in a PVA hydrogel matrix by adopting DBSA as a bifunctional molecule linking agent. Specifically, through the pi-pi stacking effect of one end of a DBSA molecule and CNTs and ionic bonding of the other end of the DBSA molecule and PANI, an active material is stitched to a conductive skeleton on the molecular level, and a highly integrated three-dimensional conductive network is formed. The interface engineering design starting from the molecular level fundamentally solves the problem of structure degradation of PANI in the cycle process, endows the electrode material with good cycle stability, excellent rate capability and enhanced charge storage capability, and also has excellent mechanical flexibility.

This application discloses an embedded whole-cell biosensor, its fabrication method, and its application in machine learning-assisted mercury ion detection, belonging to the field of sensor materials and detection technology. This sensor encapsulates *E. coli* expressing green fluorescent protein (GFP) in a polyacrylamide / hyaluronic acid (PAAM / HA) hydrogel matrix, enabling highly selective and sensitive detection of mercury ions. It effectively eliminates interference from competing metal ions and can be completely regenerated through EDTA-2Na treatment, allowing for repeated use without performance loss. It maintains a stable fluorescence response for up to three weeks, possesses excellent biocompatibility and biodegradability, minimizing the risk of secondary contamination, and facilitates rapid on-site analysis.

The invention relates to the technical field of biological preparations, and discloses a periodontitis improving compound preparation containing fermented lactobacillus mucus and traditional Chinese medicine extracts, and the periodontitis improving compound preparation comprises the following raw materials: an oral preparation: fermented lactobacillus mucus CQPC202403 bacterial powder; the gel comprises scutellaria baicalensis, honeysuckle, salvia miltiorrhiza, liquorice and a hydrogel matrix; the preservation number of the lactobacillus mucus CQPC202403 in the China General Microbiological Culture Collection Center (CGMCC) is CGMCC NO.31106, and the preservation date of the lactobacillus mucus CQPC202403 is June 27, 2024. The lactobacillus mucilaginosus adopted by the invention inhibits pathogenic bacteria through competitive rejection and immunoregulation; the traditional Chinese medicine extracts such as the radix scutellariae directly destroy bacterial pellicles, and the radix scutellariae and the traditional Chinese medicine extracts cooperate with each other, so that the antibacterial effect is enhanced on the premise of not causing drug resistance.

The invention relates to a preparation method of a fluorescence sensor. The invention relates to a preparation method of a portable pesticide detection fluorescence sensor of silver nanocluster (AgNCs) at zeolite imidazolate skeleton (ZIF) at polydopamine (PDA) and application of the portable pesticide detection fluorescence sensor in on-site rapid detection of 2, 4-dichlorophenoxyacetic acid (2, 4-D), and belongs to the technical field of fluorescence sensors. The method comprises the following steps: wrapping AgNCs with ZIF, and modifying the surface of the AgNCs with dopamine to form an AgNCs-ZIF-PDA composite material with high stability, high fluorescence enhancement, high enzyme responsiveness and high controllability; then, the material is integrated into a nano clay-acrylamide hydrogel matrix with high fitness, and a sensor with an adjustable shape is constructed. The sensor can be adaptively attached to the surface of a plant and is used for long-term in-situ monitoring of 2, 4-D pesticide. And in combination with an image processing algorithm, the system realizes accurate tracking of the tomato plant surface 2, 4-D degradation process, and the detection limit reaches 23.3 ng / mL. According to the invention, non-intrusive and low-cost technical support is provided for crop health management and sustainable precision agriculture.

The application belongs to the technical field of analysis and detection, and discloses a chiral detection platform based on a hydrogel SERS chip and application thereof.The core of the application is that the inherent chiral structure of a hydrogel matrix in a specific hydrogel SERS chip is found and utilized for the first time, so that specific enantiomers of chiral molecules can be directly and highly selectively recognized and detected without any exogenous chiral modifier or complex separation process.When the chip is used for detection with levomeprazole as a model analyte, only levomeprazole can be selectively adsorbed and produce a strong characteristic SERS signal, and the response of the dextrogyratory enantiomer is weak under the optimal conditions of an acid medium with pH 4.The sensor constructed by the method exhibits high sensitivity to levomeprazole, and the detection limit reaches 1.0x10 ‑7 mol / L, excellent selectivity and good anti-biological matrix interference capability, thereby providing a novel, simple and efficient solution for rapid analysis of chiral drugs.

The invention discloses an ROS responsive hydrogel delivery system as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The hydrogel delivery system is prepared from sulfur-doped ginger carbon dots (SGCDs) and an ROS (reactive oxygen species) responsive sulfhydrylation hyaluronic acid (HS) hydrogel matrix, the SGCDs have excellent antioxidant and anti-inflammatory activity, and can be used for clearing ROS and simulating SOD and CAT enzyme functions; the HS hydrogel matrix triggers gelling in an inflammation part high ROS environment, and targeted drug release and colitis part retention are achieved. Through the synergistic effect of the SGCDs and the HS hydrogel matrix, the delivery system can efficiently remove ROS, promote polarization of macrophages from M1 type to M2 type, up-regulate an anti-inflammatory factor IL-10, down-regulate proinflammatory factors TNF-alpha, IL-1beta and IL-6, repair Occludin and remodel the intestinal flora homeostasis.

The present application relates to the technical field of biomedical materials, in particular to an engineered small extracellular vesicle hydrogel enriched with PD-L1 and Siglec-15, and a preparation method and application thereof. The engineered small extracellular vesicle hydrogel is simultaneously enriched with PD-L1 and Siglec-15, and comprises a hydrogel matrix and PDL1-Siglec15-sEVs loaded in the hydrogel matrix, wherein the PDL1-Siglec15-sEVs are small extracellular vesicles overexpressing PD-L1 and Siglec-15. Compared with natural small extracellular vesicles and traditional wound treatment strategies, the engineered small extracellular vesicle hydrogel of the present application can realize more precise immune microenvironment regulation at the local wound by enriching PD-L1 and Siglec-15 in the vesicles, moderately inhibit excessive inflammatory response, promote the phenotype transformation of macrophages to a phenotype conducive to tissue regeneration, help smooth transition from the inflammatory stage to the proliferation and reconstruction stage, and the hydrogel as a carrier can provide a moist healing environment and a three-dimensional scaffold structure, significantly prolong the residence time of the engineered small extracellular vesicles at the local wound, and realize slow release.

This invention belongs to the field of personal health care and functional materials, and specifically relates to a long-acting sustained-release nasal inhaler combining microcapsule technology and hydrogel technology, and its preparation method. A method for preparing a long-acting sustained-release nasal inhaler combining microcapsule technology and hydrogel technology includes the following steps: S1, preparing compound essential oil microcapsule powder; S2, preparing a hydrogel matrix; S3, mixing the compound essential oil microcapsule powder and the hydrogel matrix at a mixing speed of 100-200 rpm for 15-30 min to obtain the nasal inhaler. The preparation method of this invention, by constructing a dual sustained-release system of "microcapsule-hydrogel," significantly prolongs the action time of the active ingredients, aiming for a sustained-release duration exceeding 24 hours, and making its release curve more stable, avoiding the problems of initial overconcentration and later inactivation, thus achieving long-acting, stable, and controllable release of essential oils.

The invention relates to the technical field of biological medicines, and particularly discloses a chronic wound healing promoting traditional Chinese medicine compound loaded wound and ulcer paste, which comprises a hydrogel matrix and a traditional Chinese medicine compound, and the traditional Chinese medicine compound is prepared from the following raw materials in parts by weight: 5-15 parts of rheum officinale, 4-8 parts of bletilla striata, 15-25 parts of astragalus membranaceus, 5-15 parts of salvia miltiorrhiza, 1-5 parts of cinnamon and 0.5-1.5 parts of borneol. The wound and ulcer paste loaded with the traditional Chinese medicine compound for promoting chronic wound healing can continuously and stably act on a target organ, the wound is isolated from the outside to prevent infection, meanwhile, the drug effect can be better brought into play, and therefore the treatment effect of chronic wound healing is improved.

The invention discloses double-response hydrogel as well as a preparation method and application thereof. The double-response hydrogel comprises a three-dimensional porous network hydrogel matrix, and tea polyphenol and nano silicon nitride which are loaded in the hydrogel matrix, the three-dimensional porous network hydrogel matrix is prepared from o-nitrobenzene grafted hyaluronic acid and carboxyl phenylboronic acid modified methyl chitosan. According to the hydrogel disclosed by the invention, in a low-pH / high-ROS microenvironment of a diabetic periodontitis focus, boric acid ester bonds are broken, tea polyphenol is released, and the tea polyphenol plays an anti-inflammatory role by efficiently removing active oxygen and inhibiting inflammatory factors; meanwhile, the Schiff base bond is dissociated to release the nano silicon nitride, and the nano silicon nitride significantly promotes angiogenesis and osteogenic differentiation and accelerates bone defect repair by activating a redox signal, inducing cell autophagy, regulating metabolic reprogramming and other pathways.

The invention discloses ROS (reactive oxygen species) responsive hydrogel loaded with hypoxia-induced exosome as well as a preparation method and application of the ROS responsive hydrogel. The ROS responsive hydrogel comprises an ROS responsive hydrogel matrix and a hypoxia-induced exosome dispersed in the ROS responsive hydrogel matrix, and the ROS responsive hydrogel matrix is prepared by uniformly mixing hyaluronic acid grafted with 3-aminophenylboronic acid and epsilon-polylysine grafted with caffeic acid. Under a high ROS environment, boric acid ester bonds in the hydrogel can be destroyed to release exosomes and caffeic acid, and the exosomes induced by hypoxia contain more factors for promoting tissue repair and regeneration and also have the competitive advantage of high uptake rate. The ROS responsive hydrogel loaded with the hypoxia-induced exosome can realize on-demand release of the exosome, delivers the exosome with endogenous competitive advantages to an ischemic infarction region and removes excessive active oxygen to play a role in efficiently repairing myocardial infarction.

The invention belongs to the technical field of nursing dressings, and particularly relates to a gel dressing for wound nursing and a preparation method thereof. The gel dressing for wound care is prepared from the following raw materials in parts by weight: 2 to 10 parts of sodium alginate, 1 to 20 parts of gelatin, 1 to 3 parts of a nano compound and 1 to 3 parts of glycerol, the nano-composite is prepared from nWH and GA (Glycolic Acid); zinc ions and gallic acid are released preferentially in the wound inflammation period, and the antibacterial and antioxidant effects are achieved rapidly; calcium, phosphorus and magnesium ions are released in the later healing stage, and immunoregulation and tissue regeneration are promoted; meanwhile, the nano-composite is combined with sodium alginate and a gelatin hydrogel matrix, a hydrogel network provides a uniformly dispersed stable carrier for the nano-composite, and an ideal wet healing environment is created for the wound due to the excellent liquid absorption, water retention and air permeability of the hydrogel network; and the gelatin component endows the dressing with excellent cell adhesion.

The invention discloses a traditional Chinese medicine hydrogel preparation for relieving horse petheca tendinitis as well as a preparation method and application of the traditional Chinese medicine hydrogel preparation. Wherein the traditional Chinese medicine hydrogel preparation for relieving horse pepperel tendinitis comprises a traditional Chinese medicine compound liquid and a hydrogel matrix, and the mass ratio of the traditional Chinese medicine compound liquid is 85% or above; the traditional Chinese medicine compound liquid is prepared from the following components in parts by mass: 15 to 25 parts of herba lycopodii, 10 to 20 parts of pericarpium zanthoxyli, 4 to 8 parts of herba menthae, 8 to 12 parts of radix angelicae sinensis, 8 to 12 parts of folium artemisiae argyi, 4 to 7 parts of cortex lycii radicis, 5 to 15 parts of flos lonicerae, 4 to 6 parts of herba taraxaci, 3 to 8 parts of rhizoma chuanxiong and 10 to 20 parts of vinegar. The traditional Chinese medicine hydrogel preparation disclosed by the invention can be used for relieving inflammatory response, so that the recovery period of horse swelled tendon is shortened.