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Hydrogel materials and discloses polypyrrole nano composite conductive hydrogel and preparation method thereof

A polypyrrole nano-composite conductive technology, applied in the field of biomedical hydrogel materials, can solve the problems of uneven conductive hydrogel, poor dispersion, unstable electrical properties, etc., achieve excellent biocompatibility, and solve poor dispersion , no toxic side effects

Active Publication Date: 2019-04-16
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the poor dispersion of general conductive polymer materials will lead to the inhomogeneity of the prepared conductive hydrogel and the shortcomings of unstable electrical properties, which limit the application of the conductive hydrogel

Method used

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  • Hydrogel materials and discloses polypyrrole nano composite conductive hydrogel and preparation method thereof
  • Hydrogel materials and discloses polypyrrole nano composite conductive hydrogel and preparation method thereof
  • Hydrogel materials and discloses polypyrrole nano composite conductive hydrogel and preparation method thereof

Examples

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Embodiment 1

[0032] A preparation method of polypyrrole nanocomposite conductive hydrogel, comprising the following steps:

[0033] (1) Stir and mix 120 μl of pyrrole monomer and 20 mL of 1M hydrochloric acid solution under ice bath conditions, add 0.01 g of dopamine hydrochloride, and wait for it to completely dissolve to obtain a mixed solution; 0.67 g of FeCl 3 6H 2 O was dissolved in 5 mL of 1M hydrochloric acid solution to obtain FeCl 3 / HCl solution; the prepared FeCl 3 / HCl solution was slowly added to the above mixed solution drop by drop, about 5s for one drop, kept stirring in an ice bath for 6h, and centrifuged at a speed of 6000r for 3 times, the obtained black precipitate was polypyrrole nanomaterial, which was freeze-dried and stored;

[0034] (2) Weigh 4g of gelatin into a reagent bottle with a lid, then add 40mL of phosphate buffer solution (pH=7.4, concentration 0.067M), and stir at 60°C until the gelatin is completely dissolved; use a pipette to take 3mL of formazan A...

Embodiment 2

[0040] A preparation method of polypyrrole nanocomposite conductive hydrogel, comprising the following steps:

[0041] (1) Take 180 μl of pyrrole monomer into a round-bottomed flask containing 30 mL of 1M hydrochloric acid solution, stir in an ice bath, weigh 0.03 g of dopamine hydrochloride in the flask, and wait until it is completely dissolved; weigh 0.99 g of FeCl 3 6H 2 O was dissolved in a small beaker containing 7.5mL of 1M hydrochloric acid solution, and magnetically stirred until it was completely dissolved to obtain FeCl 3 / HCl solution; the prepared FeCl 3 / HCl solution was slowly added to the above mixed solution drop by drop, about 4s per drop, and kept stirring for 8h under ice bath; the above liquid was transferred to a centrifuge tube and centrifuged 3 times at a speed of 7000r, and the obtained black precipitate was polypyrrole nanomaterial. freeze-dried storage;

[0042] (2) Weigh 5g of gelatin into a reagent bottle with a lid, then add 50mL of phosphate ...

Embodiment 3

[0047] A preparation method of polypyrrole nanocomposite conductive hydrogel, comprising the following steps:

[0048] (1) Take 240 μl of pyrrole monomer into a round-bottomed flask containing 40 mL of 1M hydrochloric acid solution, stir in an ice bath, weigh 0.2 g of dopamine hydrochloride in the flask, and wait until it is completely dissolved; weigh 1.34 g of FeCl 3 6H 2 O was dissolved in a small beaker containing 10 mL of 1M hydrochloric acid solution, and magnetically stirred until it was completely dissolved to obtain FeCl 3 / HCl solution; the prepared FeCl 3 / HCl solution was slowly added to the above mixed solution drop by drop, about 3s per drop, and kept stirring for 10h under ice bath; the above liquid was transferred to a centrifuge tube and centrifuged at a speed of 10000r for 3 times, and the obtained black precipitate was the polypyrrole nanomaterial. freeze-dried storage;

[0049] (2) Weigh 7g of gelatin into a reagent bottle with a lid, then add 70mL of p...

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Abstract

The invention belongs to the technical field of hydrogel materials and discloses polypyrrole nano composite conductive hydrogel and a preparation method thereof. The method comprises the following steps of a, using pyrrole as a monomer and dopamine as a dopant for in-situ chemical oxidative polymerization to prepare a polypyrrole nano material; b, uniformly mixing the polypyrrole nano material, modified gelatin and a photoinitiator in a solvent, and carrying out ultraviolet light initiation polymerization to obtain the polypyrrole nano composite conductive hydrogel. The modified gelatin is obtained by modifying gelatin with methacrylic anhydride. According to the hydrogel material, by modifying polypyrrole with dopamine, the polypyrrole nano material is obtained; the polypyrrole nano material can be well dispersed in a hydrogel matrix material and meanwhile can stably exist under the hydrogen bond action with hydrogel molecules. The prepared conductive hydrogel has excellent conductivity and stable chemical property, and the mechanical property of the hydrogel is improved.

Description

technical field [0001] The invention relates to a polypyrrole nanocomposite conductive hydrogel and a preparation method thereof, belonging to the technical field of biomedical hydrogel materials. Background technique [0002] With the rapid development of the field of tissue engineering, hydrogel materials have attracted much attention due to their unique extracellular matrix-like components. However, traditional hydrogel materials can no longer meet people's increasing functional needs, especially the repair of electrically sensitive tissues, such as muscle tissue, myocardial tissue, and nerves. Therefore, conductive hydrogels emerged as the times require, which combine the dual properties of hydrogels and conductive substances, and are expected to be ideal biomedical materials. For example, studies have shown that conductive hydrogels play an important role in promoting neuronal cell adhesion and proliferation and inducing nerve regeneration (Xu, D., et al. "Micro-nano-s...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L89/00C08L79/04
CPCC08J3/075C08J2389/00C08J2479/04
Inventor 宁成云胡诗迁姚甜甜陈俊祺周蕾
Owner SOUTH CHINA UNIV OF TECH
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