1085 results about "Pipette" patented technology

To precisely locate a position of a pipette tip to a designated position of a reservoir and to a designated well of a well plate.SOLUTION: A dispensing device includes: a dispensing head in which a liquid suction and discharge device is arranged; a plurality of pipette tips which are attached to the dispensing head; a moving mechanism which moves the dispensing head; a from-below imaging device for imaging the plurality of pipette tips from below; a from-top imaging device for imaging the reservoir and well plate from above; a lower-side image recognition unit which recognizes a horizontal position of the pipette tip relative to the dispensing head; an upper-side image recognition unit which recognizes a horizontal position of the reservoir and a horizontal position of the well plate; a path determination unit which determines a movement path of the dispensing head for each pipette tip to be used depending on the horizontal positions of the pipette tip, the reservoir, and the well plate; and a drive control unit which controls the movement mechanism according to the movement path determined by the path determination unit.SELECTED DRAWING: Figure 1

A microplate holder comprises a top shell portion comprising a plurality of holes constructed and arranged to receive a pipette; and a bottom shell portion constructed and arranged to couple to the top shell portion, the top shell portion and the bottom shell portion configured to at least partially enclose a microplate having a plurality of wells vertically aligned with the plurality of holes of the top shell portion, the bottom shell portion having a bottom region that exposes a bottom surface of the microplate to a light generating source that provides backside illumination for a photoactivation process regarding liquid contents of the microplate.

The invention relates to the technical field of biological sample detection equipment, and discloses a biological sample detection card box and a biological sample detection method. The biological sample detection card box comprises a box body assembly, a pipetting suction head and a plunger assembly, wherein the pipetting suction head and the plunger assembly are arranged on the box body assembly; the box body assembly comprises a bottom box, a packaging film, a detection box and an upper box rotationally matched with the bottom box, a sample storage area, a liquid storage area and a detection area are arranged at the end, close to the upper box, of the bottom box, a plurality of detection holes corresponding to the detection area are formed in the end, away from the upper box, of the bottom box, the packaging film seals the liquid storage area, and the detection box is arranged on the bottom box and corresponds to the detection area; the detection box is used for arranging at least two detection tubes for storing detection reagents, and the upper box is provided with a sample adding hole; the pipetting suction head is used for sucking and transferring liquid; the plunger assembly is used for sealing the detection pipe. The biological sample detection card box solves the problem of single detection index in the prior art, so that the practicability is high, and meanwhile, the detection efficiency and precision are improved.

The present invention discloses a pipette tip comprising a molded body made from an electrically insulating material, with an outer surface, an inner surface, and a translucent or transparent feature allowing visibility through both surfaces. The pipette tip further includes at least one impedance or capacitance electrode made from an electrically conductive material, positioned on the outer surface away from the translucent or transparent feature. Each electrode is electrically isolated on the outer surface, ensuring accurate and reliable measurements during liquid handling operations. This innovative design provides enhanced visibility and precise electrical measurements, making the pipette tip ideal for various laboratory applications.

A high-throughput automated chemical synthesis workstation, relating to the technical field of chemical synthesis. The workstation comprises a base. The base is detachably provided with a negative pressure suction filter, a magnetic stirring reactor, a high-throughput chemical reaction module, a pipette tip box, a cover plate, and a liquid storage tank, wherein the negative pressure suction filter and the magnetic stirring reactor can be replaced with other testing instruments; a screw is lap-jointed on the cover plate; a moving device is also mounted on the base, and a tightening assembly, a gripper assembly, and a pipetting assembly are mounted on the moving device; and pipetting is performed by the pipetting assembly, the gripper assembly drives the cover plate to move to the high-throughput chemical reaction module for sealing, and after tightening is performed by the tightening assembly, the gripper assembly drives the sealed module to move to the reactor, thereby achieving real-time observation during remote operation.

The technology relates in part to a segmented pipette tip adapter that includes a plurality of plate segments and a junction between adjacent plate segments. Each of the plate segments often includes a proximal surface, a distal surface, edges, one or more nozzles disposed on the proximal surface, and one or more tubular projections disposed on the distal surface. Each of the nozzles often includes a nozzle bore, each of the tubular projections often includes a tubular projection bore, each of the plate segments often includes a plate bore disposed at each of the nozzles, and each nozzle bore often is aligned with a tubular projection bore and a plate bore. Each junction often is between adjacent edges of a pair of adjacent plate segments.

The utility model discloses a sample treatment and detection integrated device, and belongs to the field of medical examination and inspection instruments and molecular diagnosis and detection instruments. According to the technical key points, the system comprises a system outer cover assembly, a loading round chassis assembly and a rotary liquid transfer device assembly, the object-carrying circular chassis assembly comprises an object-carrying circular chassis; a waste liquid bin, a magnetic bead lysis solution bin, a reagent tube, a PCR tube and a washing liquid bin are uniformly arranged on the loading round chassis; an insertion cylinder is further arranged in the middle of the loading round base plate; the rotary liquid transfer device assembly comprises a rotary liquid transfer device; the offset pipette comprises an upper through pipe interface, a lower pipe interface and an offset pipe; the lower portion of the first vertical through pipe is connected with the upper through pipe connector, and the upper portion of the second vertical pipe is connected with the lower through pipe connector. The first vertical through pipe and the second vertical pipe are located on the same vertical axis, and the first vertical through pipe is communicated with the offset pipe.

The invention relates to a high-precision micro-pipetting device and a control method thereof, and the pipetting device, the high-precision micro-pipetting device comprises a control module, a positive pressure system, a negative pressure system, a three-way solenoid valve and a pipetting head, the control module controls the switching of the three-way solenoid valve to enable a micro-control solenoid valve to be communicated with the positive pressure system or the negative pressure system, and the control module controls the opening time of the micro-control solenoid valve; a proportional valve, a pressure sensor and a flow sensor are arranged between the three-way electromagnetic valve and the micro-control electromagnetic valve, the proportional valve is used for adjusting the pressure and the flow of a gas circuit, and the control module conducts PID control on the proportional valve according to measurement data of the pressure sensor and the flow sensor. The positive / negative pressure value and the gas flow rate of the gas circuit are adjusted through the proportional valve, so that the positive / negative pressure at the liquid suction head can be changed, the suction and discharge of samples with different viscosities can be realized, the switching time of the liquid suction head is controlled through the micro-control electromagnetic valve, and the sample amount of each time of pipetting can be accurately controlled.

The invention relates to the technical field of cell passage, and particularly discloses a cell passage device which comprises a pipetting mechanism, a material standby mechanism and an uncovering mechanism, the pipetting mechanism comprises a space mover and a pipetting assembly installed at the output end of the space mover, and the space mover is used for driving the pipetting assembly to move in the space; the material standby mechanism is used for placing test tubes, opening test tubes filled with liquid raw materials and opening standby test tubes; the cover opening machine is used for opening and closing covers of the culture dishes; the pipetting assembly comprises a pressing device, a rotating base and a plurality of pipetting guns, the rotating base and the pressing device are both installed at the output end of the space mover, the pipetting guns are distributed in the circumferential direction of the rotating base, the rotating base is used for rotating the pipetting guns to work stations, and the pressing device is used for pressing pressing heads of the pipetting guns located at the work stations to suck liquid or discharge the liquid; the pressing device is used for pressing a push head rod after the push head rod is aligned to the pipette to replace the pipette head; the pipetting mechanism further comprises a waste container located below the pipetting gun and a gun head set containing a plurality of gun heads of different specifications, the pipetting gun can be inserted into the gun heads of the gun head set to assemble new gun heads, and the gun heads or waste liquid pushed out of the pipetting gun can be received by the waste container. According to the scheme, the automatic operation of cell passage is realized, the automatic suction of the pipette and the automatic replacement of the pipette head can be realized in the pipetting process, and the control simplicity and convenience of the pipetting mechanism are ensured.

The invention relates to the technical field of life science, in particular to a full-automatic nucleic acid extraction system and process, and the system comprises a complete machine frame, a sample adding and waste liquid treatment mechanism, an oscillation magnetic suction heating mechanism, a control system and a screen interaction system. The sample adding and waste liquid treatment mechanism realizes three-dimensional accurate positioning through transverse and longitudinal movement guide rails and a vertical movement assembly, comprises a large piston device and a small piston device which are connected in parallel, and can flexibly switch different volumes of pipettes and share a connector; the oscillation magnetic suction heating mechanism integrates oscillation, heating and magnetic suction functions and is matched with multi-specification suction heads and kits to complete sample treatment. According to the extraction process, all the mechanisms are linked through a control system, and full-flow operation such as sample cracking, solid-liquid separation, magnetic bead purification and elution is automatically completed. The nucleic acid extraction device realizes automation and precision of nucleic acid extraction, improves the operation efficiency and the extraction effect, and is suitable for nucleic acid extraction of samples such as plant tissues, animal tissues, blood and plasmids.

Described herein are various fluid provision systems that may be used in a laboratory setting. The fluid provision systems minimize waste of pipetted liquid sample or reagents and may be used, e.g., in combination with a multi-well plate such as in NGS processes. Other systems include those configured for compatibility with centrifuge rotors or multichannel pipettes with 12 or more channels.

Devices, kits, and methods for samples, including devices, kits, and methods for the collection, transport, and / or testing of semen samples are described herein. A kit for a sample is provided, which includes a sample device having a body, a first cap configured to removably couple to the body at a first open end, and a second cap configured to removably couple to the body at a second open end. A cap can include an opening and a removable plug to seal the opening and / or a seal that receives a pipette and automatically seals when the pipette is removed. The kit can include a stand for holding one or more sample devices and / or a preservative suitable for preserving the sample at room temperature for between 1-120 hours or more.

The invention discloses a six-degree-of-freedom precise pipettor adjusting platform based on friction driving and pressure feedback, and relates to the field of laboratory equipment.The adjusting platform comprises a platform shell, a top cover fixed to the top of the platform shell and an objective table arranged on the inner side of the platform shell and used for installing a pipettor; a pitching supporting mechanism is installed on the inner side of the platform shell, and a plurality of pitching posture adjusting mechanisms are installed on the top of the top cover. The pitch attitude adjusting mechanism comprises a supporting base fixed to the top of the top cover, a friction box fixed to the top of the supporting base and a friction rod connected to the friction box in a sleeving mode. By adopting the friction driving technology, the problem of mechanical clearance of a traditional gear or a ball screw is effectively solved, and the multi-dimensional parallel platform has the advantages of low cost, low noise and high response speed, so that the multi-dimensional parallel platform can perfectly replace a traditional six-foot parallel platform, and high-precision and quick response adjustment of a pipette tip in a multi-dimensional direction is realized.

Device for containing liquid, of the type container or circulation circuit, and methods of manufacturing this device. The invention relates to a device (1) for containing liquid, of the type container or thermal regulation circuit with heat transfer fluid, comprising at least one metal wall (2) which has openings (3, 3') for the passage of the liquid through said wall (2), a supply or discharge pipette (4, 4') being present on the external face of said wall (2), at the level of each opening (3, 3') and being connected in a hermetic manner to the opening (3, 3') concerned.Device (1) characterized in that each pipette (4, 4') is a pipette made of thermoplastic material, attached exclusively indirectly to the metal wall (2), around the relevant opening (3, 3'), through an intermediate metal piece (5), assembled directly with the outer face of said metal wall (2), and / or, through an intermediate piece or layer made of thermoplastic material (5'), attached by welding or overmolding onto the outer face (2') of said metal wall (2) or onto an intermediate metal piece (5) assembled directly with said outer face (2') of the metal wall (2). Figure to be published with the abbreviation: Fig. 5A.

The invention belongs to the technical field of laser volume calibration, and particularly relates to a laser volume calibration system for a laboratory portable pipettor, which comprises a volume calibration equipment main body and a calibration container, and is characterized in that the volume calibration equipment main body is integrated with an integrated optical measurement module, a data acquisition and intelligent processing unit and a man-machine interaction module; the height change of the liquid level center point can be accurately measured, the specific forms such as the contact angle, the curvature radius and the depth of the liquid level meniscus can be captured and analyzed in real time through images, the liquid level form correction module can accurately calculate the missing volume caused by the concave meniscus by using the parameters, and the accuracy of the missing volume is improved. According to the method, the actual liquid level height is calculated and compensated to the final actual liquid level height, the systematic measurement deviation caused by neglecting the geometrical shape of the meniscus in a traditional single laser ranging method can be fundamentally solved, the volume measurement precision is remarkably improved, and the calibration precision can be improved to a new level.

A pipette tip extension having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and encloses an inner cavity which is delimited by the inner side of the exterior wall. The exterior wall forms at the proximal end a reception aperture. The pipette tip extension further has one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.

The sealing device comprises a first sealing assembly and a second sealing assembly, the first sealing assembly is arranged at the end, away from a gun head, of an inner cavity, the first sealing assembly comprises a sealing lantern ring, a first pressing plate and a first sealing ring, the sealing lantern ring is embedded in the inner cavity, and the first pressing plate is arranged on the first sealing ring. The first pressing plate is partially embedded in the inner cavity and abuts against the sealing lantern ring, the sealing lantern ring is in interference fit with the outer diameter of the piston rod, and the first sealing ring is arranged on the outer wall of the sealing lantern ring in a sleeving mode so as to apply radial pressing force to the sealing lantern ring; the second sealing assembly is arranged at the joint of the cylinder body and the gun head and comprises a second sealing ring, a second pressing plate and a push plate, the gun head is sleeved with the second sealing ring, the second pressing plate is embedded in the cylinder body and presses the gun head, and the push plate is connected to the cylinder body so as to press the second pressing plate. According to the technical scheme, the sealing effect and durability of the pipettor are improved.

A pipette tip extension attachable to a pipette tip is disclosed. The pipette tip extension has a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip. The pipette tip extension also has a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, and one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.

The invention relates to virtual pipetting. The method for generating the control program of the laboratory automation equipment comprises the steps that configuration data of the laboratory automation equipment are received, and the configuration data encode the positions of components in the laboratory automation equipment; generating a three-dimensional model of the assembly of the laboratory automation equipment according to the configuration data, wherein the three-dimensional model further comprises a virtual pipette; displaying the three-dimensional model by using a virtual reality headset; receiving movement data of a motion sensing controller controlled by a user wearing the virtual reality headset, the movement data indicating three-dimensional movement of the motion sensing controller in space; determining movement of the virtual pipette in the three-dimensional model according to the movement data and updating the three-dimensional model according to the movement; a control program for the laboratory automation device is generated on the basis of the movement data, and the control program moves a pipette-bearing pipette arm of the laboratory automation device relative to the assembly on the basis of the movement of the virtual pipette in the three-dimensional model.

Disclosed is a dosing tool for receiving pipette tips for aspirating or dispensing a sample comprising. The dosing tool comprises a first dosing channel extending along a first longitudinal axis, a second dosing channel extending along a second longitudinal axis with a spanning distance to the first dosing channel along a transverse axis, and a first linkage mechanism for engaging the first dosing channel and the second dosing channel. The first linkage mechanism is configured for converting a translational movement along the first longitudinal axis to a spanning movement along the transverse axis.

The invention relates to the technical field of medical inspection equipment and portable cold chain control, in particular to a foldable temporary inspection reagent refrigeration box temperature control and pipettor waste liquid early warning system. The system is composed of a semiconductor refrigeration and phase change cold storage composite temperature control unit, a reagent position RFID and expiration management module, a temperature, humidity and vibration monitoring module, a waste liquid collection and liquid level and component monitoring unit, an edge control and information interaction terminal, a pipettor interface control module, a folding state detection module and a power supply and battery management module. 2-8 DEG C closed-loop temperature control and timing temperature return are realized; when the event is close to a threshold value, alarming and prohibiting cover opening, and locking suction and discharge; and recording the cold chain and tracing. According to the technical scheme, 2-8 DEG C closed-loop temperature control and timing temperature returning are achieved, automatic temperature control tightening, cover opening forbidding, suction and exhaust locking and chain type tracing are achieved in the abnormal state, and the problems that temperature control beside a mobile station is disjointed with authority, and tracing is insufficient are solved.

The present invention relates to the field of gene detection technology, and specifically discloses a molecular diagnosis pretreatment device and a molecular diagnosis pretreatment method, in which the opening mechanism includes a clamping assembly for clamping a cover body and a tube fixing assembly for fixing a sample tube, and the clamping end of the clamping assembly can rotate relative to the tube fixing assembly around the axis of the sample tube; the pipette in the cup-dividing mechanism is used to transfer the sample in the sample tube to multiple test tubes; the extraction mechanism includes a beating assembly and an extraction assembly, and the beating sleeve in the beating assembly is slidably arranged on the frame along the axial direction of the test tube, and can reciprocate in the test tube of the extraction station; the magnetic bar in the extraction assembly is slidably arranged on the frame along the axial direction of the test tube, and can enter the beating sleeve or move out of the beating sleeve, and the transmission mechanism is used to transfer the sample tube and the test tube. The above arrangement improves the extraction effect, is not easily contaminated, and improves work efficiency.

The invention relates to the technical field of pipetting guns for biological tests, and particularly discloses an automatic pipetting device which comprises a space mover and a pipetting assembly installed at the output end of the space mover, the space mover is used for driving the pipetting assembly to move in space, and the pipetting assembly comprises a pressing device, a rotating seat and a plurality of pipetting guns. The rotating base and the pressing device are both installed at the output end of the space mover, the multiple pipettes are distributed on the rotating base in the circumferential direction, the rotating base is used for rotating the pipettes to work stations, and the pressing device is used for pressing pressing heads of the pipettes located at the work stations so as to suck liquid or discharge the liquid. And the pressing device is used for pressing down the push head rod after the push head rod of the pipette head is replaced by aiming at the pipette. The scheme is used for solving the problems that the capacity of a pipette in an existing pipetting device is fixed and single, the wide measuring range required by scientific research experiments cannot be covered, and the replacement automation degree of a pipette head of the pipette is insufficient.

An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, a pipettor carried by the tool head, the pipettor having a pipette tip engaging member configured to releasably engage pipette tips, and a supplemental container holder configured for holding a supplemental container, the tool head configured to automatically position the pipette tip engaging member into a position in which an engaged pipette tip is inserted into a sample container held in the sample container holder, and into a position in which an engaged pipette tip is inserted into a supplemental container held in the supplemental container holder, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.

Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins / toxins, viruses, DNA, and / or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect and identify. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.

The utility model relates to the technical field of pipettors, and discloses a portable semi-automatic pipettor which comprises a pipettor body, one side of the pipettor body is provided with an open slot, the interior of the open slot is rotatably connected with a connecting column, the outer side of the connecting column is fixedly connected with a supporting plate, and the outer side of the supporting plate is fixedly connected with the pipettor body. A first gear is fixedly connected to the outer side of the connecting column, a second gear is connected to one side of the first gear in a meshed mode, the second gear is rotationally connected with the inner wall of the open groove, and an extension mechanism is arranged at one end of the supporting plate. The problems that a semi-automatic pipettor can be hung through the pipettor support, the liquid suction position cannot make contact with a table top, if the pipettor support does not exist in actual use, the pipettor makes contact with the table top easily, so that sample pollution is caused when a sample is sucked, and the pipettor needs to be carried together with the support when carried are solved.

The present application relates to a light-initiated chemiluminescence detection apparatus and detection method. The detection apparatus comprises: a sample feeding module; a reagent module; a pipetting mechanism comprising a first driving assembly and a pipettor, wherein the pipettor can be driven by the first driving assembly to move in a three-dimensional space and can be connected to disposable pipette tips, so as to transfer a sample and a first reagent; a cup grasping mechanism comprising a second driving assembly and a cup grasping assembly, wherein the cup grasping assembly can be used for grasping reaction cups, and is driven by the second driving assembly to perform positional dispatching on the grasped reaction cups; an incubation mechanism, which comprises a rotary disk configured to circumferentially load a plurality of reaction cups, and incubates sample-reagent mixtures in the reaction cups; a detection mechanism, which is arranged on the incubation mechanism and is configured to perform light initiation and detection on the incubated sample-reagent mixtures; and a liquid-filling assembly, which completes at a specific position the filling of a second reagent into the reaction cups. The solution provided in the present application can omit a washing procedure in chemiluminescence analysis and detection, thereby improving the detection efficiency.

The invention provides a liquid level detection method based on air pressure detection, which is applied to a pipetting system, and the pipetting system comprises a suction head; the liquid level detection method comprises the steps that the whole pipetting system is driven to move towards a target container in the first direction, the suction head is driven to suck air in the second direction at the preset speed, and the preset speed is smaller than or equal to 0.6-3 uL / s; detecting real-time air pressure; whether a suction head makes contact with liquid in the target container or not is judged according to the real-time air pressure, and when the suction head makes contact with the liquid, the liquid level position of the liquid is recorded, and the suction head is controlled to stop sucking air. The liquid level detection method based on air pressure detection is beneficial to shortening the pipetting time and improving the pipetting accuracy. The invention further provides a pipetting method and system based on air pressure detection and a computer readable storage medium.

The utility model discloses a cell identification pipettor with a heat preservation structure, and relates to the technical field of cell identification pipettors, the cell identification pipettor comprises a heat preservation shell and a pipettor body, the heat preservation shell comprises a shell I and a shell II, and a heat preservation sleeve is movably sleeved between the shell I and the shell II; the heat preservation sleeve is movably connected to the outer end of the pipettor body in a sleeving mode, bottom supports are fixedly connected to the positions, close to the inner wall of the lower end face, between the first shell and the second shell, the heat preservation sleeve is arranged above the bottom supports, a rectangular opening is formed in the outer wall of the heat preservation sleeve, and a window is fixedly arranged on the outer wall of the first shell. A sleeve block and a fixing block are fixedly connected to the outer walls of the two sides of the first shell and the second shell correspondingly, by arranging the heat preservation shell and the heat preservation sleeve structure, the effect of fixing the pipettor body is achieved, and the problem that due to the fact that a traditional pipettor is not provided with a heat preservation shell structure, the sample temperature may change when the transfer time is long is solved.

The utility model belongs to the field of medical instruments, and particularly relates to a pressing type quantitative dropper, in the pressing type quantitative dropper, a main pipe body, a soft rubber connecting piece and a pressing piece are integrally formed through injection molding (such as double-color mold injection molding), the pressing piece and the main pipe body are connected through the soft rubber connecting piece, and elastic force for resetting after pressing is provided for the pressing piece every time; according to the design, the pressing piece and the main pipe body are connected without assembling, welding and the like, the structure is simple, the production and manufacturing process is simplified, and machining and manufacturing are convenient.