2694 results about "Pipette" patented technology

The smart medical compliance method and system invention prevents adverse drug events through the use of protocols that uniquely identifies the patient, care provider, medication and/or medical device that is to be used with radio frequency identification (RFID). The RFID devices incorporate fail-safe locks or indicators that prevent the inadvertent or unauthorized use of medication, medical devices, or medical supplies. The system corroborates, patient, the care provider, the medical device, and the manner in which it is to be used, and authorizes the action to be undertaken through an interface on a personal digital assistant PDA over a wireless communication channel. The system also timestamps events in the equivalent of a medical black box such that records may be kept to further improve patient care and allow an analysis of procedures. In addition, the system includes interfaces to medication preparation and safe disposal. A number of smart devices that interact with the system are also described. These include smart medical containers, smart clamps, smart valves, smart syringes, smart couplers, smart pipettes, and a host of other point of care devices.

A pipette device has a coupling stud on which a pipette tip can be stuck in a slipping-on direction for coupling. The coupling stud has an adjustable pre-stress member that can be adjusted into a prestress state and a release state via an actuation device which is provided in the coupling stud. The pipette tip has an axial stop which interacts with a counter-stop of the coupling stud in an axial coupling position of the pipette tip. The prestress member in its prestress state acts upon a working surface of the stuck-on pipette tip having a surface component of the pipette tip, which extends radially inward, turned away from the stuck on direction, in such a way that it abuts sealingly on the working surface, and prestresses the pipette tip on the pipette unit into the axial coupling position. The prestress member, in its releasing state, substantially releases the working surface of the pipette tip (101).

A system for managing bulk liquids for an automated clinical analyzer. The system comprises (a) at least one local reservoir for storing a bulk liquid for impending use, (b) at least one container for holding a bulk liquid before the liquid is transferred to a local reservoir, and (c) a controller for monitoring the level of a bulk liquid in a local reservoir. The local reservoir for storing a bulk liquid for impending use can be a trough. The use of troughs for storing a reagent, a diluent, or some other treating agent for impending use enables an aspirating/dispensing device having a plurality of pipettes to aspirate and dispense the reagent, diluent, or other treating agent at a high rate of throughput. The controller can monitor the level of a liquid in (a) a local reservoir for storing a bulk liquid for imminent use and the level of liquid in a (b) container for holding a bulk liquid before the liquid is transferred to a local reservoir. In the laboratory automation system described herein, the container for holding a bulk liquid before the liquid is transferred to a local reservoir can be a bottle. Other desirable features in the system include, but are not limited to, pump(s), valves, liquid level sensors.

A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.

A pipette station is described for use in the field of sample analysis. The pipette station increases the rate and ease with which a liquid may be manipulated into and out of sample carriers such as microwell plates. The pipette station includes shafts in the X, Y, and Z direction which possess ball screws which are integrated with motor shafts thus improving accuracy and eliminating the need for a coupling apparatus thereby reducing the space required for the pipette station. The pipette station may be interfaced with an automated laboratory system.

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

Stackable pipette tips having increased accuracy are provided through a unique pipette tip comprising a collar, a barrel and an acutely tapered neck transitioning between the collar portion and the barrel portion. The pipette tip of the present invention has a significant reduction of inner volume resulting from the acute taper and several other tapers along the inner surface. This reduction of inner volume provides a tip with greater accuracy, as less air must be displaced in order to aspirate and dispense small aliquots of liquid. The pipette tips of the present invention also are directly stackable in a rack on one another without interaction causing lodging, binding or clinging between the outer surface of the top or stacked tip and the inner surface of the base or bottom tip.

A pipettor device and pipette tip for aspirating, mixing, manipulating and dispensing nano-volumes of fluid comprising a directed gas flow along the exterior tip surface to assist in dispensing the liquid.

An air displacement pipette having axially spaced annular sealing and substantially cylindrical lateral support zones and regions on the pipette's mounting shaft and tip, respectively, in combination with structure for insuring uniform depth of mounting shaft penetration into the pipette tip to maintain uniform tip interference with the mounting shaft as successive tips are mounted on and ejected from the mounting shaft whereby the pipette tip is easily and firmly mountable on and easily ejectable from the pipette tip mounting shaft by the application of axial mounting and ejection forces of about two pounds and one pound, respectively.

The present invention is directed generally to devices and methods for manipulating laboratory pipettes in a programmable manner. The present invention is directed to an apparatus and methods for allowing a user to instruct the device to perform a specific process; identifying the type, location and identity of the consumables to be used; manipulating a plurality of pipettes for performing the liquid handling; monitoring the process during and after its execution; generating a detailed report for the plurality of actions. Other aspects of this invention include optimization of the liquid dispensing performances of a pipette; monitoring and controlling individual actions by means of vision; virtualization of the protocol definition by means of a reality augmented software interface; integration of the system in a conventional laboratory environment workflow.

“A positioning device is provided for positioning pipettes in medical-technical applications including at least one pipetting apparatus with at least one pipette as well as several drive units for positioning a pipette tip and for moving it over a working area and transversely to a working area, a sliding carriage that is moveable transversely to the working area supports the pipette, at least one pump drive with at least one pump and at least one pump chamber is provided for aspirating or dispensing a medium, such that by providing the at least one pump drive with pump and at least one pump chamber integrated in the sliding carriage that is moveable transversely to the working area, the design of the positioning device becomes compact and precise pipetting is achieved.

A volume adjustable manual pipette having a hand-holdable housing supporting (i) an electronic digital display and associated position sensing and control circuitry, (ii) a plunger unit and (iii) a quick set volume adjustment mechanism for simultaneously controlling the volume setting of the pipette and the electronic display, the quick set volume adjustment mechanism comprising a pipette volume setting member for limiting upward movement of the plunger unit within the housing to define the volume setting for the pipette and the volume setting member being supported for axial movement on the plunger unit and releasably secured relative to the housing by a pipette user operable locking mechanism. When released from the housing, the volume setting member is axially moveable on and with the plunger unit to quickly set the volume for the pipette. When secured to the housing, the plunger unit is axially moveable relative to the volume setting unit to aspirate and dispense the selected volume of liquid into and from a pipette tip extending from a lower end of the housing. The volume setting of the pipette is monitored by the sensing and control circuitry to provide a real time display of the volume setting of the pipette.

The invention relates to a method for dosing a volume of liquid (VF) of less than 1 !l that is to be dispensed, by means of a dosing pump, in particular a pipette (2). According to said method, a tip (13) is completely filled with a liquid and contains the liquid (16) to be dispensed at least in the vicinity of its outlet (13a), a volume of gas (VL) is drawn into the tip (13) via the outlet (13a) and a volume corresponding to the sum of the volume of liquid (VF) to be dispensed and the volume of gas (VL) is then supplied to the tip (13) in such a way that the volume of liquid (VF) is dispensed via the outlet (13a) in a contactless manner. The device comprises a plurality of dosing pumps that can be simultaneously actuated, in particular pipettes (2), which can be actuated by an injection plunger (6), in addition to a motor (1), which drives the injection plungers (6) and also a valve (3), which is located between the dosing pump and its respective tip (13) in order to fill each system completely with liquid without any gas.

A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

A pipette dispensing block has an improved piston seal and lift plate engagement/disengagement means. In a pipette dispensing block where a piston is used to create a pressure differential to aspirate or extract and dispense or eject fluid material, the maintenance of a vacuum or increased pressure is enhanced by a pair of O-ring seals engaging the piston. A reservoir separates the O-rings and is filled with a low vapor pressure lubricant such as silicone oil or grease. The lubricant is maintained in the reservoir by the O-rings and serves to enhance the vacuum seal while maintaining the O-rings in a pliable and resilient manner. The heads of the pistons are engraved or grooved to leave a circular central pillar surrounded above and below by the piston head and a lower intermediate piston pillar section. The individual pistons are arranged in straight rows so that a slat may slip through opposite pairs of opposing piston pillars thereby entrapping the pistons and preventing them from sliding past the lift plate as the lift plate is lifted upwardly. Shoulders present on the pistons below the lift plate serve to allow the lift plate to push the pistons into the cylindrical chambers of the head block so that a pipette dispenser is provided. The lift plate or portions thereof are then trapped between the slats and the piston shoulders, coupling the pistons to the lift plate. Upward and downward control is thereby established and maintained by the lift plate on the pistons.

An air-filled pipette for accurately metering small and large volumes of fluid samples is provided. The pipette has dual resolution capability such that the pipette can accurately aspirate a wide range of sample volumes and deliver them contact-free (touchless). The pipette may include an extension mandrel that reduces air space in a disposable tip within the pipette. The dual resolution capability and/or the extension mandrel also minimize errors associated with the compressibility of air. Multiple pipettes may also be arranged to form a pipetting module for the metering of multiple sample volumes simultaneously and automatically. The pipette includes a channel block having at least one cylindrical passage, that slides up and down over a rod, and a cylinder, with an axially extending passage therethrough, that is sized, shaped and aligned to fit into the cylindrical passage in a dynamic sealing relationship. A method for mixing multiple fluid samples within a pipette tip is also provided.

A handheld multichannel pipette includes multiple fluid-handling nozzles and a rotary adjustment mechanism for adjusting the width of a pattern of nozzles while maintaining equal spacing between pairs of nozzles. Embodiments of the adjustable-spacing multichannel pipette include an adjustable stop mechanism.

A wiping cap closure device used for removing the non-calibrated residue fluid attached to the outside surface of a pipette tip during the fluid transfer from a container. The wiping cap is constructed using a conical shaped resilient wiper section extending to a conical tip. The conical shaped wiper section is configured to include at least one helical formed slot extending from said conical tip forming at least one wiping finger. The wiping finger is resiliently held against the outside surface of the pipette tip inserted therethrough during the fluid transfer. The wiping finger provides squeegee like means to remove all of the non-calibrated residue fluid inadvertently attached to the outside surface of the tip as the pipette tip is withdrawn from the container leaving the non-calibrated residue fluid within the container for further evaluations or tests.