106 results about "Laboratory automation" patented technology

The invention belongs to the field of laboratory automation equipment, and discloses a control method and system of a task execution device for physical and chemical experiment operation, and the method comprises the steps: initializing and calibrating the device; receiving and analyzing an experiment task instruction; collecting object information through a visual sensor; the upper computer generates an execution scheme according to the strategy library; the electric control rotary clamping jaw is driven to complete operation; force and displacement parameters are monitored in real time, and dynamic adjustment actions are fed back through a closed loop; and judging that the operation is completed according to the threshold. The system comprises a visual sensor, a rotary driving body, an electric control rotary clamping jaw and an upper computer. By integrating visual identification and force sense feedback, fine operations such as clamping, taking and placing, bottle cap screwing and the like can be completed in a self-adaptive mode, the efficiency, precision and reliability of laboratory automatic operation are remarkably improved, manual operation errors are reduced, and good application prospects are achieved.

The invention discloses a sample self-relay method for laboratory real-time quality control and an automatic system, and belongs to the technical field of clinical laboratory automatic quality control. According to the method, an independent quality control cycle is established for a plurality of preset key concentrations, and a concentration-bias and concentration-inaccuracy mapping table is established based on historical quality control data. Independent counting is maintained for each target concentration, when the detection number reaches the length L of the current analysis batch, quality control is automatically triggered, two patient samples with the concentrations meeting the requirements are screened from the current detection batch to serve as a self-relay quality control sample pair, and judgment is conducted according to the rule of 1-3 s after returning and re-detection. And meanwhile, querying a mapping table according to the actual concentration of the sample to calculate a sigma value, querying a preset sigma-L mapping table based on the sigma value, and dynamically updating the next analysis batch length of the target concentration. Each cycle operates independently and asynchronously to form a closed loop, so that accurate, automatic and real-time quality control of different concentrations and different frequencies is realized, and the implementation bottleneck of personalized 6 sigma quality control in cost and reliability is overcome.

The invention belongs to the technical field of laboratory automation equipment, and discloses an EP tube automatic cover opening and closing device which comprises a shell. A through groove is formed in at least one side wall of the shell; the pipe frame carrier is arranged on the outer side of the shell and corresponds to the through groove in position; the pipe frame carrier is provided with a pipe groove used for containing an EP pipe. The transmission structure is arranged in the shell; and the opening and closing cover pressing plate is connected with the transmission structure, the transmission structure drives the opening and closing cover pressing plate to swing relative to the connecting position, external force is applied to a cover body of the EP pipe placed in the pipe groove of the pipe frame carrier in the swinging process, and cover opening or closing operation is achieved. The two actions of cover pressing and cover lifting can be completed only through positive and negative rotation of the motor, and cover opening and closing are integrated.

The invention discloses a liquid distribution device, and belongs to the technical field of laboratory automation equipment, the liquid distribution device comprises a treatment station, the treatment station is provided with a horizontal moving arm, a liquid distribution placing rack and a waste liquid placing rack, the tail end of the horizontal moving arm is provided with a liquid injection needle head, and the liquid distribution placing rack and the waste liquid placing rack are both located below the liquid injection needle head; a liquid level sensor is arranged on the liquid injection needle head and used for monitoring whether internal liquid continuously passes through the liquid injection needle head or not during single-time liquid injection, the liquid separation containing frame is used for containing a liquid separation container, the waste liquid containing frame is used for containing a waste liquid container, and the horizontal moving arm moves horizontally according to the monitoring result of the liquid level sensor. And the liquid injection needle is driven to inject liquid into the liquid separation container or the waste liquid container. An air column can be exhausted into a waste liquid container before liquid separation, in the liquid separation process, whether liquid injection is interrupted and loss is stopped in time or liquid supplementation is conducted after liquid injection continues can be determined according to a liquid level sensor, the problem of liquid shortage caused by the air column can be solved from the initial stage and the liquid separation stage, and dual guarantee is achieved.

The invention relates to a material handling unit for a mobile industrial robot (1) for the automation of laboratories in the field of laboratory medicine, and to a laboratory installation comprising the mobile industrial robot (1) and the material handling unit mounted on the industrial robot (1). The material handling unit includes a carrier (2) mountable on the industrial robot (1) and one or more sample handling units (3), each containing a sample holder (6) for receiving laboratory sample containers and a sample holder grip (5) for secure fixation. In combination with the mobile industrial robot (1), the material handling unit enables optimized sample logistics through the rapid provision and transport of laboratory samples, reduction of the travel distances of the industrial robot (1), and increased process efficiency.

The invention belongs to the technical field of biological laboratory automation equipment, discloses a control method and system for automatic subpackaging of a culture medium, realizes a high-precision and automatic liquid subpackaging process by combining volume calibration and point position calibration with an end effector, solves the problems of large manual liquid adding amount, complex volume calibration, liquid leakage and the like in a laboratory, and improves the working efficiency. Workload can be effectively reduced, efficiency and quality of laboratory culture medium equipment are improved, and the device is widely applied to laboratories of daily chemicals, medicines, food, health care products, environments and the like.

An automatic standing device for blood collection tubes comprises a rack, a feeding unit, a code scanning unit and a conveying unit, the feeding unit, the code scanning unit and the conveying unit are installed on the rack, the feeding unit conducts discretized feeding on the blood collection tubes, the code scanning unit is used for obtaining information of the blood collection tubes, and the automatic standing device for the blood collection tubes further comprises an allocating unit and a standing cache unit; the conveying unit conveys the blood collection tubes to the allocating unit, the allocating unit shifts the blood collection tubes needing to be stood into the standing cache unit according to code scanning information, the standing cache unit comprises a cache bin, and the cache bin comprises a cache distribution box and at least two sequential cache bins arranged at equal arc intervals. Each temporary storage bin is defined by a temporary storage distribution box, blades and a visual door and window, all the blades are installed on a blade installation shaft, and the blade installation shaft is connected with a blade driving assembly used for driving the blades to rotate. On the premise that manual intervention is not needed, transmission stress is effectively relieved, the hemolysis rate is remarkably reduced, and meanwhile the continuity and high efficiency of an automatic process of a laboratory are guaranteed.

The invention discloses a medical laboratory automation system based on OPC. The medical laboratory automation system comprises an upper computer control layer, a business logic layer, a communication layer, an execution layer and a database layer. The upper computer control layer adopts WinCC configuration software to realize experiment monitoring and visualization; the business logic layer is responsible for task scheduling management based on a Java application program; the communication layer realizes real-time data interaction among the layers through an OPC protocol; the execution layer comprises a PLC control module, an AGV transportation unit and a collaborative robot unit, and completes experiment operation in a collaborative manner. And the database layer stores the whole-process data. According to the system, by establishing an OPC UA real-time communication link between Java and WinCC, instruction and state feedback delay is remarkably reduced, and data synchronization reliability is ensured; an intelligent scheduling algorithm and a fault-tolerant control mechanism are combined to realize efficient execution of tasks and dynamic allocation of resources; by constructing a complete processing closed loop, the automation and intelligence level of a medicine laboratory is effectively improved, manual intervention is greatly reduced, and the experiment efficiency and the result reliability are improved.

The utility model relates to the technical field of medical laboratory equipment, and discloses a medical laboratory automatic assembly line and a sample support rail transfer device, the sample support rail transfer device comprises a reversing disc rotatably arranged between a sample injection rail and a cache rail and a reversing power assembly used for driving the reversing disc to rotate; the reversing disc is fan-shaped, and one end of the reversing disc is provided with a reversing groove which is matched with the sample support to drive the sample support to rotate; when the reversing disc is located at the working position, one end of the reversing disc is matched with the partition plate to separate the sample injection track from the cache track; when the reversing disc is located at the pre-track-changing position, the reversing disc cuts off the sample injection track, and the direction of the reversing groove is opposite to the sample injection direction of the sample injection track, so that the sample support enters the reversing groove along the sample injection direction; when the reversing disc is located at the track transfer position, the reversing groove is aligned with the cache track, the orientation of the reversing groove is the same as the cache direction of the cache track, so that the sample support is separated from the reversing groove, the structure is simple, the cost is low, the track transfer action is simple, and the track transfer efficiency is high.

The application discloses a phosphate dispensing device structure and belongs to the field of laboratory automation equipment. The dispensing device structure comprises a liquid storage tank, a dispensing pump controlled by a PLC controller device and communicated with the liquid storage tank, a dispensing pipeline fixedly installed on an output port of the dispensing pump, a dispensing head fixedly installed on the dispensing pipeline and away from the dispensing pump, and a heat preservation mechanism arranged on the liquid storage tank and the dispensing pipeline. The heat preservation mechanism comprises a first heating part arranged on an outer side wall of the liquid storage tank and attached to the outer side wall of the liquid storage tank. The heat preservation mechanism further comprises a second heating part arranged on an outer side wall of the dispensing pipeline and wrapped on the dispensing pipeline. The dispensing device structure heats and preserves the liquid in the liquid storage tank and the dispensing pipeline, so that the solution is always in a suitable dissolving state, the low-temperature crystallization phenomenon is avoided, and the clogging probability of the dispensing head is effectively reduced.

Laboratory automation systems and instruments are disclosed herein comprising components that may facilitate de-contamination of the instrument using an airborne disinfectant. Maintaining the airborne disinfectant within a predetermined range can be achieved by creating a feedback loop between generating the airborne disinfectant from a disinfectant solution. Instruments disclosed can comprise vaporization modules in communication with reservoirs of a disinfectant solution, or receive cleaning cartridges comprising the disinfectant solution, which may be energized to generate the airborne disinfectant. Decontamination methods are also disclosed herein.

A method for detecting a leak rate of a displacement pump (2,15) integrated in a laboratory automation apparatus (1) comprising a valve (4,10), the displacement pump and a pressure sensor (3); a) closing the valve (4,10); b) pressurizing the system (21) with a liquid to an initial pressure P1 using the displacement pump (2,15); c) monitoring the pressure by the pressure sensor (3) during time period Δt starting from initial pressure P1 at time t1; d) detecting a second pressure P2 at t2 at the end of the time period Δt, wherein pressure P2 is below pressure P1 when leakage occurs; e) repressurizing the system to pressure P1 by displacing an additional volume ΔV of the liquid using the displacement pump (2,15), and f) calculating the leak rate by dividing the additional volume ΔV by the predetermined time period Δt.

The application discloses a kind of based on three-dimensional vision's chemical synthesis intelligent operation platform and control method thereof, belong to laboratory automation and intelligent manufacturing field.The platform includes three-dimensional vision acquisition module, point cloud physical property correction module, geometric matching and pose calculation module, motion control and safety constraint optimization module, self-supervision compensation learning module, drift detection and automatic calibration module, safety confidence decision module and mechanical arm execution module, each module is formed closed loop control system by data interface.The application is corrected by constructing refraction compensation model based on Fermat principle, optical deviation caused by transparent vessel and liquid level;Combined with fluid dynamics constraint optimization motion trajectory, prevent liquid splashing and cross contamination;Through self-supervision learning and automatic calibration mechanism, inhibit long-term running in coordinate drift, improve system accuracy and stability.The application can realize high-precision, high robustness and essential safety of automated chemical synthesis operation.

The application relates to the technical field of laboratory automation management and data processing, in particular to a detection consumable allocation method and system based on comprehensive efficiency optimization and a storage medium, a predicted sample quantity in a future early warning period is output by calling a sample quantity prediction model, and a single-specification reservation coefficient is dynamically determined accordingly, so that safe inventory control considering current task execution and future demand shortage prevention is realized; on the basis, a plurality of candidate allocation schemes are generated within the limitation, multi-dimensional efficiency calculation is carried out in combination with a single-specification unit cost, a to-be-detected sample quantity, a fixed control site quantity and real-time residual effective time, a consumable cost performance, actual utilization rate and inventory turnover efficiency obtained are fused into a comprehensive efficiency value for final decision, the limitation of traditional single-dimensional extensive allocation is avoided, on the premise of meeting the absolute well site demand of single detection, the overall high procurement cost is reduced, well site vacancy waste is reduced and near-efficiency period consumables are accelerated.

The invention discloses an automatic rotary evaporation method based on a collaborative robot. The automatic rotary evaporation method comprises the following steps that the collaborative robot is controlled to position and grab an anti-splashing ball; the splash-proof ball is installed on the rotary evaporator interface in a force control flexible mode; then the evaporation bottle is grabbed and installed to a lower connector of the splash-proof bottle in the same mode; a rotary evaporation process is started and monitored; and after finishing, controlling the robot to sequentially disassemble the evaporation bottle and the splash-proof ball and return. The force sensing and compliance control capability of the collaborative robot is utilized to simulate the touch sense of manual operation and self-adaptive adjustment, so that the grabbing and butt joint of the precise glassware can be completed automatically, compliantly and without collision, the damage risk of the glassware is avoided, the assembly stress is eliminated, the full-process automation of the rotary evaporation experiment is realized, and the production efficiency is improved. The defects of manual operation in the aspects of efficiency, safety and consistency are effectively overcome, and the automation level of a laboratory and the reliability of experimental results are remarkably improved.

This invention discloses a digital twin-based experimental process simulation and resource scheduling optimization system, belonging to the field of laboratory automation technology. The system includes: a digital twin environment module for constructing a full-element digital twin of the laboratory, containing the geometric attributes, kinematic constraints, and logical states of experimental equipment; an AI shadow pre-simulation engine for accelerating pre-simulation within the digital twin before the formal experiment, using a spatiotemporal scanning algorithm to complete conflict detection; a multi-constraint dynamic scheduling module for generating an optimized instruction set containing timestamps and spatial path constraints based on the pre-simulation results to schedule physical equipment to perform experimental operations; and a bidirectional synchronization closed-loop module for achieving real-time synchronization between the virtual model and the physical environment through an adaptive filtering mechanism. This invention effectively avoids the risk of hard collisions in concurrent multi-robotic arm operations, optimizes experimental process timing, and improves laboratory operating efficiency and fault tolerance.

A method for separating particles (64) using a laboratory automation device (10) includes: mounting a particle separator (20) to a pipetting arm (14) of the laboratory automation device (10), wherein a first pipetting tip (18a) and a second pipetting tip (18b) are connected to the pipetting arm (14), wherein the particle separator (20) is mounted by inserting the first pipetting tip (18a) into a first receiving portion (40a) of the particle separator (20) and inserting the second pipetting tip (18b) into a second receiving portion (40b) of the particle separator (20); creating a pressure difference between a first chamber (58a) and a second chamber (58b) of the particle separator (20), such that a suspension (62) in the first chamber (58a) and the second chamber (58b) moves through the interconnecting first chamber (58a) and the second chamber (58b). 8a) and a connecting channel (60) for the first chamber (58a) and the second chamber (58b), wherein the first chamber (58a) is interconnected with the first receiving portion (40a) and the second chamber (58b) is interconnected with the second receiving portion (40b), and wherein different pressures are applied to the first chamber (58a) and the second chamber (58b) via a first pipette tip (18a) and a second pipette tip (18b) connected to at least one pressure generator (32) of the laboratory automation device (10); an impedance signal (76) is determined using a measuring device (34) of the laboratory automation device (10), the impedance signal (76) indicating the impedance of the suspension (62) within the connecting channel (60); and particles (64) in the suspension (62) passing through the connecting channel (60) are detected by evaluating the impedance signal (76).

The invention discloses a sample analysis system which comprises a system sample loading device and a system analysis device, the system sample loading device comprises a sample bearing area, a sample scheduling transmission module and a sample transfer module, and the system analysis device comprises a first sample analyzer and a first analysis system transmission device matched with the first sample analyzer. Wherein the sample bearing area is used for bearing samples; the sample transfer module is at least used for transferring samples between the sample bearing area and the sample scheduling transmission module; the sample scheduling transmission module is configured to be arranged between the main rail transmission system and the first analysis system transmission device and be in butt joint with the main rail transmission system and the first analysis system transmission device when being in butt joint with the main rail transmission system so as to interact samples with the main rail transmission system and the first analysis system transmission device; and the first analysis system transmission device is used for transmitting the samples from the sample scheduling transmission module to the corresponding first sample analyzers, so that the first sample analyzers analyze and process the samples. The invention further discloses a system sample loading device, a full-laboratory automatic assembly line and a control method of the full-laboratory automatic assembly line.

A framework provides an integration of a system for a planar motor transport with laboratory equipment for performing multiple automated laboratory functions directly within the same operating environment. The framework includes a distributed control architecture and processes for performing workflow agent execution logic, and transport and execute of devices and movers for performing automated workflows with workflow agents. Together the integration of the system for planar motor transport with the distributed control architecture and associated processes enable functions such as combining liquid handling operations, sample access operations, cleanup and recovery operations, and others into a single, scalable platform.

The utility model relates to the technical field of PLC (Programmable Logic Controller) control panels, and provides a high-grade laboratory automatic control rapid wiring board, which comprises a printed circuit board provided with a power supply input module, a power supply output module, a flat cable seat, a port signal input / output interface, a relay module and a PLC mounting area, the power output module is arranged on the lower side of the PLC installation area, the flat cable seat is arranged on the lower side of the power output module, the relay module is arranged on the right side of the PLC installation area, the power input module is arranged on the right side of the relay module, the port signal input and output interface is arranged on the edge of the printed circuit board, and the flat cable seat is electrically connected with the port signal input and output interface. The PLC signal circuit is drawn in the printed circuit board, and various interface plug connectors are used for circuit access, so that the wiring work becomes neat and visual, the installation work efficiency is improved, and the error probability is reduced.

The application discloses a laboratory automation sample storage cabinet, comprising: a cabinet frame and two storage shelves arranged in the cabinet frame, the two storage shelves being oppositely arranged along the left side and the right side in the cabinet frame and used for storing sample trays; a sample tray switching platform arranged at the front side of the storage shelf and used for temporary placement and transfer of the sample tray; a fork mechanism arranged between the two storage shelves and the sample tray switching platform and used for carrying out the sample tray on the storage shelf or placing the sample tray into a corresponding position or carrying the tray on the sample tray switching platform to the storage shelf; and a four-axis robot arranged on the cabinet frame through a linear movement module and located above the sample tray switching platform and used for grabbing a sample bottle and performing a transfer operation. The laboratory automation sample storage cabinet can realize modular design and realize full-process unmanned precise operation.

The invention discloses a full-automatic culture dish coating mechanism, and relates to the technical field of laboratory automation equipment. Comprising a sterilization module, a coating module, a culture dish overturning module, a culture dish rotating module and a six-axis mechanical arm, the sterilization module is used for carrying out high-temperature heating sterilization on a coating head in the coating module and carrying out real-time detection on the temperature in the sterilization process; the coating module is arranged at the tail end of the six-axis mechanical arm, comprises a rotatable coating head and is used for automatically adjusting the coating posture or contact pressure according to the height change of the surface of the culture medium in the coating process; the culture dish rotating module is used for bearing a culture dish and is matched with the coating module to complete coating operation, and the culture dish overturning module is used for clamping the culture dish and completing automatic inversion operation after coating is completed. Through cooperation of multiple modules, automatic uncovering, coating, sterilization, rotary positioning and inversion operations of the culture dishes are realized, the coating consistency, the experiment repeatability and the system automation level are improved, and the pollution risk is reduced.

This application relates to a test tube sorting, transfer, and sample liquid addition device, belonging to the technical field of laboratory automation devices. It includes a sorting module, a transfer module, and a pipetting module. The sorting module includes a test tube storage compartment for horizontally placing test tubes, a test tube sorting mechanism for sorting test tubes, and a test tube reversing mechanism for converting test tubes from horizontal to vertical orientation. The transfer module includes a rotatable test tube turntable with multiple test tube cups arranged along its edge. During the rotation of the turntable, the test tube cups sequentially connect to the outlet end of the reversing mechanism. The pipetting module includes a pipetting robotic arm and a sample liquid container. The robotic arm is used to transfer sample liquid from the sample liquid container into the test tubes located within the test tube cups. This application achieves batch storage, sorting, and orientation conversion of test tubes through the sorting module, ensuring orderly and efficient loading. Simultaneously, the intermittently rotating test tube turntable and circumferentially distributed test tube cups achieve precise flow and transport of test tubes, meeting the needs of batch processing in laboratories.

A method for sharing system information data in a network of two or more diagnostic instruments for performing assays is provided. The system information data includes operating information for the diagnostic instruments in the network. The method includes: sending a system information metadata packet to at least a first diagnostic instrument in the network, wherein the system information metadata packet, is associated with system information data on a second diagnostic instrument in the network and comprises one or more attributes of a system information data packet containing the associated system information data; receiving a request from the first diagnostic instrument to send the system information data packet, and in response to the request from the first diagnostic instrument to send the system information data packet, sending the system information data packet containing the associated system information data to the first diagnostic instrument.

Various embodiments relate to magnetically moveable displacement devices or robotic devices. Particular embodiments provide systems and corresponding methods for magnetically moving multiple movable robots relative to one or more working surfaces of respective one or more work bodies, and for moving robots between the one or more work bodies via transfer devices. Robots can carry one or more objects among different locations, manipulate carried objects, and / or interact with their surroundings for particular functionality including but not limited to assembly, packaging, inspection, 3D printing, test, laboratory automation, etc. A mechanical link may be mounted on planar motion units such as said robots.

The present invention in one aspect thereof relates to a laboratory automation device that is adapted to support an automated and continuous processing method for identifying an anti-cancer drug or anti-cancer drug combination for patients that suffer from, or are being diagnosed for, a neoplastic disease or tumor. Provided are furthermore a respective automated and continuous method for identifying an anti-cancer drug or anti-cancer drug combination as well as kits and respective uses thereof.

The disclosure relates to a method (400) comprising: - obtaining, by a computing system (100), aliquoting data, wherein the aliquoting data comprise instructions specifying that a portion of a biological sample (31) included in a first sample container (1) is to be aliquoted into a second sample container (2); - obtaining, by the computing system (100), laboratory data, wherein the laboratory data comprises information indicative of one or more laboratory instruments (22) which are to process the second sample container (2) and / or one or more laboratory locations at which the second sample container (2) is to be processed; - determining, by the computing system (100), based on at least the laboratory data, indicium data, wherein the indicium data comprise information indicative of an indicium template according to which an indicium (52) is to be generated, wherein the indicium (52) is to label the second sample container (2) and comprises identification information for identifying the second sample container (2); and - causing, by the computing system (100), the indicium (52) to be generated according to the indicium template.

A laboratory automated system includes a conveyor assembly, a dock that that is movable between first and second positions, a drive assembly for moving the dock between the first and second positions, and a diverter for diverting a sample receptacle carrier from the conveyor assembly to the dock. The dock includes a first carrier support portion having a planar surface for supporting the sample receptacle carrier as the dock moves between the first and second positions. The dock includes an upwardly extending second carrier support portion situated adjacent the first carrier support portion. The second carrier support portion has a contoured side surface. The dock includes one or more magnets fixedly contained within or disposed on the second carrier support portion to magnetically couple with a magnetic portion of the sample receptacle carrier.

A laboratory automation apparatus with a liquid volume measurement functionality comprising a working table, a pipettor comprising a pipetting head with an electrode providing a capacitive sensor with a reference electrode. A robotic arm is configured to move the pipetting head above the working table. A processor is operatively coupled to the robotic arm, to the pipettor and to the electrode by an electronic circuit. A capillary is located on the working table having an opening for receiving a target amount of liquid from the pipettor to form an air-liquid meniscus in the capillary. The robotic arm is configured to hover the electrode over the capillary to detect a change in capacitance related to the position of the meniscus, and the processor is configured to calculate the transferred amount of liquid from the position of the meniscus in the capillary.