5 results about "Target concentration" patented technology

The present invention provides a method and apparatus for adjusting the concentration of a chemical solution that allows for high-precision concentration adjustment with fewer control items and without requiring a long time for adjustment. [Solution] The concentration adjustment method is a method for adjusting a chemical solution of a predetermined concentration by mixing a stock solution containing any component with pure water, and includes the steps of: (A) mixing a predetermined amount of stock solution and pure water to obtain a mixed solution with a concentration in the range of 50% to 200% of a preset target concentration; (B) stirring the obtained mixed solution for a predetermined time and measuring the conductivity and liquid temperature of the mixed solution in the system to obtain a concentration value; and (C) calculating the amount of stock solution or pure water required to make the concentration value obtained in step (B) the median concentration between the concentration value and the target concentration, and supplying the calculated amount of stock solution or pure water to the mixed solution, and repeating steps (B) and (C) until the obtained concentration value is within a predetermined range of the preset target concentration.

In a method for the spectral analysis of a liquid mixture of substances consisting of known individual substances, a reference spectrum for the mixture is provided. This reference spectrum represents a target state of the mixture in which each individual substance is present at a target concentration. An actual spectrum of the liquid mixture to be analyzed is then generated. Finally, the concentrations of the individual substances in the mixture are determined based on an approximate spectral composition of the actual spectrum, derived from known pure spectra of the known individual substances and at least one compensation spectrum.

Provided herein are systems and methods for optimizing a biological therapy regimen for a subject. The subject may be a patient diagnosed with an immune mediated inflammatory disease. In some embodiments, the systems and methods may involve inputting patient data into a model to forecast a drug concentration level in a patient and establish a dosing regimen for maintaining a pre-specified threshold drug concentration level in the patient. The pre-specified threshold may be a target concentration level for effective treatment of the immune mediated inflammatory disease in the patient.

In a method for spectral analysis of a liquid substance mixture consisting of pre-known individual substances, a reference spectrum for the substance mixture is provided, wherein the reference spectrum represents a target state of the substance mixture in which each individual substance is contained in a target concentration. An actual spectrum of the liquid substance mixture to be analysed is created. Finally, concentrations of the individual substances in the substance mixture are determined on the basis of an approximate spectral composition of the actual spectrum from pre-known pure spectra of the pre-known individual substances and at least one compensation spectrum.

The invention provides a method for determining related substances in a vitamin B6 drug, which comprises the following steps: dissolving a vitamin B6 drug sample in a prefabricated solution in a dark environment, filtering, and diluting to a target concentration interval to obtain a sample solution; placing the blank solvent, the contrast solution and the sample solution in a chromatographic column, introducing the mobile phase A and the mobile phase B, and sequentially carrying out gradient elution to obtain a chromatogram; and identifying and separating impurity chromatographic peaks in the chromatogram, performing quantitative or semi-quantitative analysis on each impurity chromatographic peak, and calculating the content proportion of each impurity chromatographic peak relative to the main chromatographic peak of the vitamin B6. Through collaborative design of the sample pretreatment state, the gradient elution path and the peak interpretation mode, known impurities and unknown impurities in the vitamin B6 medicine are in a separable state before entering a chromatographic system, and are fully expanded in the chromatographic separation process, so that accurate identification and effective separation of various impurities are realized.