167 results about "Hydroxypropyl cellulose" patented technology

The invention relates to a cellulose-chitosan-based lithium ion battery diaphragm and a preparation method and application thereof.The preparation method of the diaphragm comprises the steps that gamma-polyglutamic acid and polyamide epichlorohydrin are adopted for modifying chitosan, the hydrophilicity and the liquid absorption capacity of the chitosan are improved, polyvinylpyrrolidone is adopted for coating the chitosan, and the hydrophilicity and the liquid absorption capacity of the chitosan are improved; pVP is replaced in ethanol soaking to form micropores, so that the porosity of the modified chitosan is improved. Amino groups and hydroxyl groups of the modified chitosan are combined with catechol of the polydopamine and hydroxyl groups of the hydroxy propyl cellulose through hydrogen bonds and covalent bonds to form a chitosan-cellulose-PDA interpenetrating network, and the diaphragm material suitable for the lithium ion battery is finally prepared by combining hot-pressing shaping. The preparation method has the advantages that the balance between the mechanical property and the ion conduction property of the diaphragm is realized through multi-component compounding by utilizing the biocompatibility and renewability of natural macromolecules (cellulose and chitosan).

The invention discloses a preparation method and application of a high-sensitivity temperature-responsive cellulose-based structural color material, and belongs to the field of functional polymer materials. The preparation method comprises the following steps: adding an isopropanol solvent into a certain volume of aqueous solution to obtain an isopropanol dilute solution; hydroxypropyl cellulose is dissolved in an isopropanol dilute solution, a cholesteric liquid crystal structure is formed through self-assembly, a bright structural color is presented, and the hydroxy propyl cellulose structural color material is prepared. A hydroxy propyl cellulose structural color material is uniformly coated on the surface of a polydimethylsiloxane film containing carbon nanotubes, then the transparent polydimethylsiloxane film is used for sealing the hydroxy propyl cellulose structural color material, the temperature sensor with the visual structural color is prepared, and the temperature sensor with the visual structural color is attached to the skin of the human body and can display different colors along with temperature changes. The prepared structural color material is sensitive in response to temperature stimulation, rapid in color change and suitable for human body visual real-time temperature monitoring in the field of intelligent sensing.

The invention provides a sustained-release pellet containing gamma-aminobutyric acid, the sustained-release pellet comprises a pellet core and a coating layer wrapping the pellet core, the pellet core contains a physiologically active substance, and the physiologically active substance is gamma-aminobutyric acid; the pellet core comprises the following components in parts by weight: 15-40 parts of gamma-aminobutyric acid, 30-55 parts of a filling agent, 1-30 parts of a lubricating agent and 0.5-5 parts of an anti-caking agent; the filling agent comprises at least one of microcrystalline cellulose, powdery cellulose, starch and derivatives thereof, hydroxypropyl cellulose, hydroxypropyl methylcellulose, low-substituted hydroxypropyl cellulose, sugar or sugar alcohol and fruit and vegetable powder; the lubricant comprises at least one of talcum powder, magnesium stearate, stearic acid, glycerol and leucine; the anti-caking agent comprises at least one of magnesium carbonate, tricalcium phosphate, calcium hydrophosphate and silicon dioxide.

The application provides a detection method of hydroxypropyl cellulose in a povidone-containing preparation, and specifically comprises the following steps: (1) preparing a sample solution by pretreating a sample to be detected; (2) detecting the sample solution by using HPLC, wherein an evaporative light scattering detector or an electrospray detector is used as a detector, a C18 chromatographic column is used as a chromatographic column, the column temperature is 20-40 DEG C, water is used as a mobile phase A, methanol is used as a mobile phase B, the flow rate is 0.5 ml / min-1.5 ml / min, and gradient elution is adopted. The detection method has good specificity and peak type, can not only separate hydroxypropyl cellulose from povidone and other high-molecular auxiliary materials in a pharmaceutical preparation, accurately quantify the content of hydroxypropyl cellulose, but also effectively identify the model, and provides a good method for reverse analysis, component analysis, auxiliary material release detection of the pharmaceutical preparation.

The invention provides a production process for improving dissolvability of hydroxypropyl cellulose, which comprises the following steps: step 1, raw material pretreatment: crushing and drying a cellulose raw material to obtain pretreated cellulose; 2, homogeneous dissolution: mixing the pretreated cellulose with an ionic liquid solvent, and dissolving under heating and stirring conditions to obtain a cellulose solution; step 3, alkalization reaction: adding an alkali catalyst into the cellulose solution, and reacting under a low-temperature condition to obtain alkalized cellulose; 4, etherification modification: adding an etherifying agent into the alkalized cellulose for etherification reaction to obtain a hydroxypropylation reaction solution; and 5, neutralizing and purifying, namely adjusting the pH value of the hydroxypropylation reaction solution, adding a precipitator to precipitate the product, and filtering, washing and drying to obtain the hydroxypropyl cellulose. Through optimization of a homogeneous reaction system and process conditions, uniform distribution of the hydroxypropyl substitution degree is realized at the molecular level, so that the dissolving property of the hydroxypropyl cellulose is remarkably improved.

The application provides an oral instant tablet containing Morinda citrifolia oil, which comprises the following components in parts by mass: Morinda citrifolia oil microemulsion 10 parts, carrier 30-40 parts, coating material 2-4 parts, and disintegrating agent 2-5 parts. The coating material is selected from Aeroperl and / or Sylysia; the carrier is selected from one or more of microcrystalline cellulose MCC PH101, microcrystalline cellulose MCC PH102, starch and lactose; and the disintegrating agent is selected from carboxymethyl starch sodium and / or low-substituted hydroxypropyl cellulose. The microemulsification technology is used to wrap the essential oil to reduce the volatilization of the essential oil; the microemulsion is made into a tablet to cover the acidity, increase the compliance of the public, and realize the form change of the Morinda citrifolia oil microemulsion from liquid to solid. The application studies and prepares the oral instant tablet containing Morinda citrifolia oil, which not only solves the inherent defects of traditional dosage forms, but also provides a more convenient taking mode compared with common tablets.

The invention provides a candesartan cilexetil capsule and a preparation method thereof, and the candesartan cilexetil capsule is characterized in that each capsule contains candesartan cilexetil, lactose, corn starch, hydroxypropyl cellulose, carboxymethyl cellulose calcium, polyethylene glycol 8000 and magnesium stearate. According to the candesartan cilexetil capsule provided by the invention, the problem of stability of candesartan cilexetil is solved, the possibility of crystal transformation of common tablets in a tabletting process is reduced, and the characteristic dissolution curve of a final product is similar to that of a reference preparation; the preparation method is simple in process route, the fluidized bed one-step granulation method enables the loss to be less, the product yield is higher, and the industrial mass production cost is reduced.

A cultivation method for improving the quality and yield of black fungus using hydrogen-rich water involves spraying a hydrogen-rich water composition three times during mycelial culture, spraying it every two days during primordium differentiation, and spraying it daily during fruiting body enlargement. The hydrogen-rich water composition comprises hydrogen-rich water, xylose, humic acid, gelatin, hydroxypropyl cellulose, and deionized water. This invention effectively solves the problems of poor hydrogen concentration stability and hydrogen volatilization in hydrogen-rich water by adding functional components such as gelatin, hydroxypropyl cellulose, xylose, and humic acid to the hydrogen-rich water, thus extending the time of hydrogen concentration stability and its effect. By using the above-mentioned hydrogen-rich water composition during the mycelial growth and primordium differentiation stages of black fungus, the microenvironment for black fungus growth is comprehensively optimized, resulting in increased yield, improved quality, and enhanced marketability. This provides an effective way to cultivate superior black fungus varieties.

A sublingual tablet and application thereof in desensitization therapy drug are provided. The sublingual tablet is a low-dose allergen sublingual tablet. The sublingual tablet includes freeze-dried powder of allergen protein, lactose, mannitol, low substituted hydroxypropyl cellulose, low moisture microcrystalline cellulose, and magnesium stearate. The freeze-drying process is adopted to obtain the freeze-dried powder of allergen protein, and the powder direct compression technology is adopted to obtain the sublingual tablet of allergen protein. The low-dose sublingual tablet has excellent properties, including appearance, hardness, tablet weight variation, disintegration time, taste, and uniformity of content, in particular has outstanding advantages in disintegration time, uniformity of content, stability, and preparation process, and has an industrial application prospect.

The invention provides a glucosamine hydrochloride capsule and a preparation method thereof, the capsule content comprises the following components in parts by weight: 240 parts of glucosamine hydrochloride, 50-60 parts of starch and 2-7 parts of hydroxypropyl cellulose; the glucosamine hydrochloride capsule prepared by controlling the particle sizes of the glucosamine hydrochloride and the starch within a specific range and using a specific adhesive is high in dissolution rate (the dissolution rate in four dissolution media for 45 minutes is not lower than 85%), and the dissolution rate is stable after the glucosamine hydrochloride capsule is placed for 24 months for a long time.

To provide a method for producing low-substituted hydroxypropyl cellulose having favorable disintegratability while maintaining sufficient compactibility.SOLUTION: A method for producing low-substituted hydroxypropyl cellulose having a hydroxypropoxy group content of 5 to 16 mass%, at least includes the steps of: bringing pulp into contact with and alkali metal hydroxide solution to obtain alkali cellulose; reacting the alkali cellulose with propylene oxide to obtain a reaction product; dispersing the reaction product into water containing at least acid to partially solubilize the reaction product, and then neutralizing the reaction product with an additional amount of acid to precipitate crude low-substituted hydroxypropyl cellulose; using a screw press to remove liquid from the crude low-substituted hydroxypropyl cellulose to obtain purified low-substituted hydroxypropyl cellulose having a water content of 50 to 60 mass%; and drying and pulverizing the purified low-substituted hydroxypropyl cellulose.SELECTED DRAWING: None

The invention belongs to the field of contact lens care, and particularly relates to a sandwich effervescent tablet for cleaning contact lenses and a preparation method of the sandwich effervescent tablet. The outer layer is prepared from the following raw materials: citric acid, sodium bicarbonate, disodium ethylene diamine tetraacetate, a surfactant, polyvinylpyrrolidone, microcrystalline cellulose and colloidal silicon dioxide; the middle layer is prepared from the following raw materials in parts by weight: sodium percarbonate, tetraacetylethylenediamine, phosphate buffer salt, a surfactant, anhydrous sodium carbonate, microcrystalline cellulose and colloidal silicon dioxide; the inner core is prepared from the following raw materials in parts by weight: catalase, a stabilizer, hydroxy propyl cellulose K4M, ethyl cellulose, microcrystalline cellulose and sodium bicarbonate. According to the invention, citric acid / bicarbonate is matched with an active agent to weaken a biological membrane in the outer layer, and a permeation channel is opened preferentially; the H2O2 platform is formed by matching middle-layer sodium percarbonate; and the inner core adopts HPMC / EC controlled-release catalase to realize hysteresis-burst release neutralization.

The present application relates to the technical field of pharmaceutical preparation, and provides a calcium carbonate tablet, which comprises the following raw materials in parts by weight: 700-800 parts of calcium carbonate, 80-100 parts of corn starch, 15-25 parts of low-substitution hydroxypropyl cellulose, 1.5-2.5 parts of polysorbate-80, 7-9 parts of protein sugar, 3-5 parts of hypromellose, 2.5-3.0 parts of magnesium stearate and 15-25 parts of sodium carboxymethyl starch; wherein the calcium carbonate is selected from calcium carbonate with a particle size of 40-80 μm; the low-substitution hydroxypropyl cellulose and the sodium carboxymethyl starch are disintegrants, and the ratio of the amount of the low-substitution hydroxypropyl cellulose to that of the sodium carboxymethyl starch is 1:1. The present application also provides a preparation method of the calcium carbonate tablet. The calcium carbonate tablet has the advantages of short disintegration time, high dissolution rate, good bioavailability and good stability.

This invention provides a drug for antagonizing bacterial endotoxins, its preparation method, and its application, belonging to the biomedical field. The composition consists of 25-55 parts of dried powdered traditional Chinese medicine extract, 25-70 parts of mixed essential oil powder, and 40-90 parts of lentinan powder. The traditional Chinese medicine extract is prepared by decoction of Scutellaria baicalensis, Lonicera japonica, Forsythia suspensa, and Isatis indigotica under reduced pressure at low temperature and spray drying. The mixed essential oil powder is prepared by encapsulating peppermint oil and eucalyptus oil with gelatin and hydroxypropyl cellulose and then spray drying under high pressure. This invention, through specific formulation and processing, significantly enhances the synergistic antagonistic effect of each component against endotoxins. Experiments show that this composition exhibits antagonistic activity far superior to ibuprofen in vitro; in vivo, it significantly reduces the endotoxin content in the plasma of 817 broiler chickens, rapidly alleviates LPS-induced fever and diarrhea, and improves decreased growth performance. Therefore, this invention is of great significance for reducing antibiotic dependence and improving the efficiency of livestock and poultry farming.

The present disclosure provides oral dosage forms comprising about 8.75% w / w deuruxolitinib phosphate, about 50% to about 60% w / w microcrystalline cellulose, about 25% to about 35% w / w lactose monohydrate, about 3% to about 6% w / w polyvinylpyrrolidone, about 2% to about 4% w / w hydroxypropyl cellulose, about 0.25% to about 0.75% w / w colloidal silicon dioxide, and about 0.25% to about 0.75% w / w magnesium stearate.

The invention discloses a preservative film agent and a preparation method thereof, and belongs to the technical field of preservation. The preservative film agent comprises the following raw materials: polyvinyl alcohol, hydroxy propyl cellulose, glycerol and an antibacterial agent, wherein the antibacterial agent is a cinnamyl aldehyde-loaded Pickering emulsion; a Pickering emulsion is dispersed in a PVA / HPC composite film agent, and a solvent pouring method is adopted to prepare the composite film with antibacterial performance. According to the invention, polyvinyl alcohol and hydroxy propyl cellulose are selected to form a film together so as to overcome the defects of a traditional film agent, and the cinnamyl aldehyde-loaded Pickering emulsion is dispersed in a composite film agent prepared from PVA / HPC, so that the comprehensive preservative film agent with good preservation effect and antibacterial ability is obtained.

Gummy or jelly candies with modified functional ingredients with controlled time-release. The invention relates to gummy or jelly candies (1) comprising at least one modified functional ingredient with controlled time-release, characterized in that they comprise, inside or on the surface, at least one modified functional ingredient (2), namely encapsulated and / or granulated, said gummy or jelly candies having the following constituents: at least one carbohydrate consisting of glucose syrup and / or sugar; at least one fiber; at least one protein; and at least one fruit in the form of concentrated juice or natural juice and / or at least one natural or artificial sweetener; at least one gelling agent; at least one flavoring; at least one coloring; said at least one modified functional ingredient which is a food functional ingredient; water;and at least one acid, the constituent (E) comprising an active substance or a functional ingredient proper (3) and an excipient, and being disposed of in capsules or granules (4), the excipient being a microencapsulation excipient in the case of capsules or a granulation excipient in the case of granules, said excipient being at least one of: glyceryl dibehenate, hydroxypropyl cellulose and / or ethyl cellulose, a constituent (E) having an excipient proportion of between 20 and 80% by weight.;

The invention discloses a preparation method for prolonging the validity period of erythromycin ethylsuccinate orally disintegrating tablets. The preparation method comprises the following steps: sequentially putting low-substituted hydroxypropyl cellulose, microcrystalline cellulose, aspartame, carboxymethyl starch sodium and polyvinylpolypyrrolidone into a wet granulation mixer, covering with a cover, starting equipment, carrying out low-speed dry mixing for 3 minutes, slowly adding low-concentration hydroxypropyl methylcellulose slurry from a feed port of a pot cover, and carrying out low-speed wet mixing for 3 minutes; stopping the machine, opening the cover, scraping powder on the inner surface of the pot cover and the periphery of the inner side of the pot by using a clean scraper, adding erythromycin ethylsuccinate raw materials, covering the cover, starting equipment, carrying out low-speed wet mixing for 3 minutes, and carrying out high-speed wet mixing for 2 minutes. By improving the medicine production process, the stability and durability of the medicine are improved, so that the validity period of the medicine is prolonged, and meanwhile, the effectiveness and safety of the medicine can still be kept within the prolonged validity period.

This invention belongs to the field of biopharmaceutical technology and discloses a tranexamic acid sustained-release composition, its preparation process, and its application. By weight, the composition comprises 100-120 parts tranexamic acid, 14-18 parts sustained-release material, 5-8 parts magnesium stearate, 2-5 parts colloidal silica, and 3-5 parts polyvinyl alcohol. The sustained-release material is selected from a combination of hydroxypropyl cellulose and ethyl cellulose, or a combination of hydroxypropyl methyl cellulose and microcrystalline cellulose, or a combination of sodium carboxymethyl cellulose and hydrogenated vegetable oil. This invention utilizes the synergistic effect of the sustained-release material and the synergistic effect between the sustained-release material and polyvinyl alcohol to maintain zero-order or first-order release of the drug, achieving a steady-state blood drug concentration and prolonging the duration of action, thereby achieving a good sustained-release effect.

The present invention provides a solid dispersion comprising lurasidone or a pharmaceutically acceptable salt thereof and a carrier. The carrier material includes polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silica, hydroxypropyl methylcellulose (HPMC), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose (HPC), povidone, copovidone, ethylcellulose, polyoxyethylene glycol, hypromellose acetate succinate (HPMCAS), hypromellose phthalate (HPMCP), or a combination thereof.

The application belongs to the technical field of building facades, and particularly relates to a color-changing glass, a manufacturing method thereof and a color-changing building facade. The color-changing glass comprises a transparent packaging shell and a thermochromic material, and the thermochromic material is located inside the transparent packaging shell. The thermochromic material is a colloid composed of hydroxypropyl cellulose and sodium chloride as solutes and distilled water as a solvent. The application can automatically change the color and transparency of the glass according to temperature changes, and reduce the sunlight directly entering the room in summer.

The invention belongs to the technical field of building facades, and particularly relates to a design method of building facade photochromic glass. The design method comprises the steps that the photochromic glass comprises a transparent packaging shell and a thermochromic material, and the thermochromic material is located in the transparent packaging shell; the thermochromic material is a colloid formed by 6wt% of hydroxy propyl cellulose, sodium chloride and distilled water; designing the photochromic glass based on the sodium chloride concentration within the range of 0-2%: calculating the sodium chloride concentration in the thermochromic material according to the first color change temperature; calculating the height upper limit of the photochromic glass when the total potential energy of the thermochromic material is above a stable potential energy threshold value based on the sodium chloride concentration; the height of the photochromic glass does not exceed the height upper limit. The reversible and uniform photochromic glass capable of automatically and stably changing the transparency according to the temperature can be designed, and indoor light in summer can be stably regulated and controlled.

This invention discloses a temperature- and pressure-sensitive, high-strength, and tough multifunctional nanocomposite hydrogel and its preparation method, belonging to the field of hydrogel technology. The invention first isolates tunicin from sea squirts and hydrolyzes it with acid to obtain sea squirt nanocellulose. Hydroxypropyl cellulose is dissolved in deionized water, sodium dodecyl sulfate is added, and the mixture is sonicated until dissolved. Then, octadecyl methacrylate, acrylamide, sea squirt nanocellulose suspension, and MXene / Ag nanosheet dispersion are added sequentially, and the mixture is mixed with an initiator. Emulsion polymerization is then performed to obtain the nanocomposite hydrogel product. The reaction disclosed in this invention is easy to operate and operates under mild conditions. Furthermore, the nanocomposite hydrogel prepared by the method disclosed in this invention exhibits high efficiency in multiple sensitivities (temperature and pressure), high strength, and excellent biocompatibility, showing broad application prospects in disease diagnosis and daily monitoring in the medical and pharmaceutical fields.

This invention discloses a conductive hydrogel, its preparation method, and its applications. The conductive hydrogel's raw materials include hydroxypropyl cellulose, hyaluronic acid, acrylamide, and a conductive agent; the conductive agent includes at least one selected from lithium chloride, potassium chloride, sodium chloride, sodium sulfate, and potassium sulfate. This conductive hydrogel utilizes the liquid-phase transition characteristics of hydroxypropyl cellulose, combined with acrylamide, hyaluronic acid, and lithium chloride to achieve respiratory and body temperature monitoring. This conductive hydrogel exhibits good conductivity and can detect different types of respiration, providing valuable monitoring for the monitoring and development of clinical diseases. Simultaneously, the synergistic effect of the combined hyaluronic acid, acrylamide, and lithium chloride adjusts the lower critical dissolution temperature of hydroxypropyl cellulose to 37°C, causing the hydrogel to change from transparent to opaque at 37°C, enabling real-time temperature and respiratory monitoring for febrile patients in clinical settings.

This invention relates to the field of laser cladding technology, specifically to a toughened and reinforced laser cladding alloy powder and its preparation process. It solves the problem of poor hardness and toughness of the cladding layer formed by existing laser cladding alloy powders during use. This laser cladding alloy powder incorporates scandium / erbium-loaded nano-silica and tannic acid-hydroxypropyl cellulose-coated boron nitride. Loading scandium and erbium onto the nano-silica improves the wear resistance and tensile strength of the cladding layer. Coating the boron nitride surface with tannic acid-hydroxypropyl cellulose powder improves the wettability between boron nitride and the metal matrix, reducing interface defects. The synergistic effect of rare earth elements and boron nitride reduces porosity and cracks in the cladding layer. It also improves density by refining grains and strengthening interfacial bonding, further enhancing the material's wear resistance and tensile strength, ensuring service life and reliability under high temperature and high stress environments.

The invention relates to a preparation method of a gradient refractive index coating with self-cleaning and anti-reflection dual functions. The preparation method comprises the following steps: (1) using a commercial glass slide as a substrate; the method comprises the following steps: cleaning exposed glass for 5 minutes in an ultrasonic bath by using ethanol, then removing ethanol in the glass slide by using deionized water, and drying the glass slide in a 70 DEG C oven; (2) dissolving 0.2 g of hydroxy propyl cellulose and 0.1 g of SiO2 in 50 mL of an ethanol solution, and carrying out ultrasonic treatment for 1 h; and (3) depositing the solution on a clean glass substrate at a lifting rate of 1000 [mu] m / s for a deposition time of 180 s through a dip coating process. And after each time of dipping, drying at 80 DEG C for 1h. The film coating time is 7 times optimally. And (4) annealing the pre-cured coating in a 300 DEG C constant-temperature furnace for 1 hour. And the obtained coating is marked as' SiO2-HPC '. The method disclosed by the invention is simple, and the obtained coating with self-cleaning and anti-reflection properties is relatively good in durability, and is used as an anti-reflection film to obviously improve the power generation efficiency of a solar cell panel.

The invention relates to a brexpiprazole oral soluble film and a preparation method thereof, the film agent does not use a thickening agent, and comprises 2%-10% of brexpiprazole, 60%-90% of a polymer film-forming material and 5%-30% of a plasticizer; the polymer film-forming material is a composition of hydroxypropyl methylcellulose and hydroxy propyl cellulose. The prepared brexpiprazole oral soluble film is flat in appearance, free of curl, uniform and smooth, free of visible particles, capable of being disintegrated rapidly and good in tensile strength and stability.

The invention relates to a high-content 5-aminolevulinic acid sustained-release pellet, which comprises the following components: 5-aminolevulinic acid phosphate; microcrystalline cellulose (MCC PH-102); hydroxypropyl cellulose (HPC-SL); 2-5% of pregelatinized starch; sodium carboxymethyl starch (CMS-Na); sucrose; the drug loading capacity is 60 + / -2%, and the bulk density is 0.65-0.75 g / cm < 3 >.

This invention relates to a choleretic traditional Chinese medicine composition, its preparation method, and its application, belonging to the field of traditional Chinese medicine preparation technology. The microcapsules prepared from this choleretic traditional Chinese medicine composition consist of a core and a coating. The core contains a traditional Chinese medicine extract, pregelatinized starch, sodium alginate, and croscarmellose sodium. The coating contains hydroxypropyl cellulose and hydroxypropyl methylcellulose E5, PEG4000, and talc. The traditional Chinese medicine extract is made from Artemisia capillaris, Lysimachia christinae, Rheum palmatum, Scutellaria baicalensis, Taraxacum mongolicum, Forsythia suspensa, Curcuma longa, Curcuma longa, Bupleurum chinense, Citrus aurantium, and Aucklandia lappa. This choleretic traditional Chinese medicine composition has the effects of promoting bile flow and expelling gallstones, detoxifying and reducing swelling, with a stable drug release rate, definite efficacy, and few toxic side effects. It can be used for the prevention and / or treatment of acute and chronic gallstones and / or cholecystitis.

A non-tobacco oral nicotine pouch composition comprising water, nicotine, and at least one sugar alcohol in an amount of at least 15% by weight of the pouch composition wherein the pouch composition is free of a humectant consisting of alginate, propylene glycol, hydroxypropyl cellulose, and glycerol is disclosed. In addition, an oral pouch nicotine product is disclosed.