373 results about "Hydroxypropyl cellulose" patented technology

The invention relates to the technical field of drilling fluids, and discloses a lignite-based modified filtrate reducer for a drilling fluid and a preparation method of the lignite-based modified filtrate reducer. The lignite-based modified filtrate reducer for the drilling fluid is obtained by stirring and mixing the lignite grafted copolymer, the hydroxy propyl cellulose and the graphene oxide, drying and crushing. The steric effect generated by an oxazine ring, a pyridine ring, a triazine ring, a benzene ring and a pyrrole ring grafted into the lignite improves the temperature resistance and salt resistance of the filtrate reducer; the dispersing capacity of clay particles in a drilling fluid system is improved through sulfonic acid hydrated groups, and high-temperature coalescence of drilling fluid clay due to the high-temperature effect is avoided; a sulfonic acid anion group and a quaternary ammonium salt cation group are introduced into the filtrate reducer at the same time, so that the filtrate reducer can form a salt internal bond under the action of electrostatic force, and the salt resistance of the filtrate reducer is improved; the nano silicon dioxide increases the rigidity of the filtrate reducer, so that the filtrate reducer is not easy to curl under the conditions of high temperature and high salt.

The invention relates to a cellulose-chitosan-based lithium ion battery diaphragm and a preparation method and application thereof.The preparation method of the diaphragm comprises the steps that gamma-polyglutamic acid and polyamide epichlorohydrin are adopted for modifying chitosan, the hydrophilicity and the liquid absorption capacity of the chitosan are improved, polyvinylpyrrolidone is adopted for coating the chitosan, and the hydrophilicity and the liquid absorption capacity of the chitosan are improved; pVP is replaced in ethanol soaking to form micropores, so that the porosity of the modified chitosan is improved. Amino groups and hydroxyl groups of the modified chitosan are combined with catechol of the polydopamine and hydroxyl groups of the hydroxy propyl cellulose through hydrogen bonds and covalent bonds to form a chitosan-cellulose-PDA interpenetrating network, and the diaphragm material suitable for the lithium ion battery is finally prepared by combining hot-pressing shaping. The preparation method has the advantages that the balance between the mechanical property and the ion conduction property of the diaphragm is realized through multi-component compounding by utilizing the biocompatibility and renewability of natural macromolecules (cellulose and chitosan).

The invention belongs to the field of food additives-compound coating agents and medicine solid preparation thin film coating premixing agents, and relates to a preparation method of a solid dispersion and a water-based gastric-soluble efficient moisture-proof coating composition containing the solid dispersion. According to the solid dispersion provided by the invention, stearic acid and magnesium stearate are selected as indissolvable components, polyglycerol fatty acid ester is used as a surfactant, hydroxypropyl methylcellulose / hydroxy propyl cellulose / sodium alginate is used as a carrier, and a grinding process is combined to treat the raw materials, so that a good synergistic effect is formed among the components; and the solid dispersion which can be stably amorphized is prepared. Tests find that the content of insoluble components in the prepared solid dispersion is obviously improved unexpectedly, and a coating composition of a carrier containing the solid dispersion has extremely excellent moisture resistance after film formation.

The invention relates to the technical field of pharmacy, and discloses a carbidopa-levodopa sustained release tablet and a preparation method thereof.The carbidopa-levodopa sustained release tablet is prepared from, by mass, 65.4%-68.0% of levodopa, 17.0%-18.5% of carbidopa, 0.1%-0.5% of an adhesive, 0.1%-0.5% of a lubricant and 0.1%-0.5% of a coloring agent. And the mass percentage of the sustained-release material is 8.0%-9.0%. According to the carbidopa-levodopa sustained-release tablet and the preparation method thereof, polyvinyl acetate-crotonic acid copolymer is selected as a sustained-release material, hydroxypropyl cellulose is selected as an adhesive, the defects existing in the prior art are overcome, the carbidopa-levodopa sustained-release tablet can well control slow release of carbidopa and levodopa, and the sustained-release effect is good. According to the present invention, the release curve is highly consistent with the release curve of the original development agent, such that the safety and the effectiveness of the medication can be significantly improved, the wet granulation process is adopted, the addition mode of the adhesive is adjusted, the granulation process problem that the granulation is not easily performed when the active component content is large is solved, the preparation process is simple, and the industrial production is easy.

The invention provides a modified cellulose thickening agent for fracturing fluid, the fracturing fluid and a preparation method of the fracturing fluid, and relates to the technical field of oil and gas exploitation. Compared with hydroxy propyl cellulose and carboxymethyl cellulose, the cellulose derivative prepared by carrying out graft modification on carboxymethyl cellulose by utilizing amino-terminated polysiloxane is used as a thickening agent, and compared with the hydroxy propyl cellulose and the carboxymethyl cellulose, the cellulose derivative disclosed by the invention has higher temperature resistance and shear resistance, good swelling property, low residue content and good stability. And the damage to the stratum is reduced.

The invention discloses a lipoic acid pharmaceutical composition and a preparation method thereof, the form of the pharmaceutical composition is wet particles, and the pharmaceutical composition comprises lipoic acid, hydroxy propyl cellulose and an ethanol aqueous solution; the preparation method comprises the following steps: adding an ethanol aqueous solution of hydroxy propyl cellulose into a lipoic acid-containing mixed material, carrying out wet granulation, and controlling the concentration of the ethanol aqueous solution to be 20-60%, the problems of sticking and cracking in the tabletting process are avoided, and process feasibility is achieved; moreover, the dosage of the ethanol aqueous solution of the hydroxy propyl cellulose is only 15-30% of the mass of the lipoic acid, so that the problem of difficult particle drying caused by excessive wetting is avoided, and industrial production is facilitated.

The present invention discloses a semaglutide oral patch and a preparation method and application thereof, belonging to the field of pharmaceutical preparations. The oral patch comprises the following ingredients: 0.3-0.8 parts of semaglutide, 0.3-0.8 parts of an absorption enhancer, 1-2 parts of a film former and 0.2-0.5 parts of a plasticizer; wherein the film former is composed of hydroxypropyl cellulose, hydroxyethyl cellulose and carboxymethyl cellulose. The oral patch of the present invention has the advantages of high drug loading, high bioavailability, excellent demoulding, mechanical properties, taste and no drug precipitation, and is used to treat type 2 diabetes.

The present disclosure is directed to oral dosage forms of TRβ agonist VK2809 and methods of preparing the same. The disclosure provides oral dosage forms of VK2809 with improved stability and solubility properties that allow for storage under normal conditions through the use of spray-drying with one or more polymers selected from the group consisting of: polyvinyl pyrrolidone (PVP), polyvinyl pyrrolidinone-vinyl acetate copolymer (PVP-VA), polyvinyl alcohol (PVA), polyacrylic acid (PAA), polyethylene oxide) (PEO), hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), copovidone, poloxamer 407, hypromellose acetate succinate (HPMCAS), polyacrylates and combinations thereof.

The invention discloses a preparation method and application of a high-sensitivity temperature-responsive cellulose-based structural color material, and belongs to the field of functional polymer materials. The preparation method comprises the following steps: adding an isopropanol solvent into a certain volume of aqueous solution to obtain an isopropanol dilute solution; hydroxypropyl cellulose is dissolved in an isopropanol dilute solution, a cholesteric liquid crystal structure is formed through self-assembly, a bright structural color is presented, and the hydroxy propyl cellulose structural color material is prepared. A hydroxy propyl cellulose structural color material is uniformly coated on the surface of a polydimethylsiloxane film containing carbon nanotubes, then the transparent polydimethylsiloxane film is used for sealing the hydroxy propyl cellulose structural color material, the temperature sensor with the visual structural color is prepared, and the temperature sensor with the visual structural color is attached to the skin of the human body and can display different colors along with temperature changes. The prepared structural color material is sensitive in response to temperature stimulation, rapid in color change and suitable for human body visual real-time temperature monitoring in the field of intelligent sensing.

The invention discloses a preparation method of thermochromic HPC / PEG hydrogel, which comprises the following steps: preparing an aqueous solution of hydroxy propyl cellulose (HPC), and slowly adding potassium persulfate (KPS) and a BIS initiator under a stirring condition to obtain HPC hydrogel; adding PEG (Polyethylene Glycol) into the HPC hydrogel, and carrying out ultrasonic mixing to obtain thermochromic HPC / PEG hydrogel; the molecular weight of the PEG is 400 to 20000; the mass percent of the PEG in the HPC / PEG hydrogel is 0 to 50 percent by weight; the thermochromic intelligent window is obtained by injecting the thermochromic HPC / PEG hydrogel between two pieces of quartz glass, then sealing the periphery and standing. By adding PEG with proper content and molecular weight, dual regulation and control of LCST and optical performance of the HPC hydrogel are realized, the problem that low response temperature and high solar modulation capability of the hydrogel cannot be achieved at the same time is solved, and the obtained HPC / PEG hydrogel has the characteristics of high transmittance, high solar modulation efficiency, low critical transition temperature and long cycle life.

The invention discloses a whitening composition as well as a preparation method and application thereof in a solid flash release soluble microneedle, and belongs to the technical field of cosmetics. The whitening composition is prepared from the following components in parts by weight: 0.2 to 0.4 part of tetrahydromagnolol, 1 to 2 parts of nonapeptide-1 and the like, and the tetrahydromagnolol and the nonapeptide-1 can synergistically generate a remarkable whitening effect; a microneedle skeleton prepared from the whitening composition comprises sodium hyaluronate, low-substituted hydroxy propyl cellulose and mannitol, and the prepared microneedle has excellent mechanical strength at 37 DEG C, can be subjected to solid flash release, and can achieve the effects of convenience in use, whitening and the like.

The invention discloses a preparation method of a brexpiprazole tablet, and belongs to the field of pharmacy, and the brexpiprazole tablet comprises the following components: brexpiprazole, lactose, corn starch, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, hydroxypropyl cellulose and sodium stearyl fumarate. By controlling specific parameters in combination with operation steps in the preparation method, the medicine with good product quality can be produced, the product quality is stable, and the content of related substances is low.

The invention discloses a method for preparing a hollow glass bead composite alumina aerogel material by a directional freezing method. The method comprises the following steps: 1, adding hollow glass beads into a hydroxy propyl cellulose solution to prepare a hollow glass bead suspension solution; 2, adding a silicon source into a calcium chloride aqueous solution, and adding the chopped alumina fibers and the hollow glass bead suspension solution to prepare emulsion gel; 3, directional freeze drying; and 4, heating to obtain the aerogel material. According to the preparation method, an emulsion-gel method is adopted, emulsion gel is taken as a soft substance matrix, and alumina fibers and hollow glass beads are combined through an ultrahigh-viscosity colloid and a structure rearrangement agent, so that the density, porosity and heat conductivity coefficient of the aerogel material are effectively regulated and controlled, and the aerogel material is endowed with flexibility while the mechanical strength of the aerogel material is improved; after high-temperature ablation, the material is stable in structure, low in heat conductivity coefficient, capable of isolating heat from passing at ultralow temperature and high temperature, simple in preparation process, low in cost, environmentally friendly and suitable for large-scale production.

The invention provides a sustained-release pellet containing gamma-aminobutyric acid, the sustained-release pellet comprises a pellet core and a coating layer wrapping the pellet core, the pellet core contains a physiologically active substance, and the physiologically active substance is gamma-aminobutyric acid; the pellet core comprises the following components in parts by weight: 15-40 parts of gamma-aminobutyric acid, 30-55 parts of a filling agent, 1-30 parts of a lubricating agent and 0.5-5 parts of an anti-caking agent; the filling agent comprises at least one of microcrystalline cellulose, powdery cellulose, starch and derivatives thereof, hydroxypropyl cellulose, hydroxypropyl methylcellulose, low-substituted hydroxypropyl cellulose, sugar or sugar alcohol and fruit and vegetable powder; the lubricant comprises at least one of talcum powder, magnesium stearate, stearic acid, glycerol and leucine; the anti-caking agent comprises at least one of magnesium carbonate, tricalcium phosphate, calcium hydrophosphate and silicon dioxide.

The invention discloses a novel thermochromic intelligent window with adjustable emissivity, comprising a window frame, a glass component installed inside the window frame, the glass component comprising a glass substrate, a metal oxide coating for adjusting the glass substrate to have a low radiation function in the mid-infrared region is deposited on one side of the glass substrate, the metal oxide coating is a layer of transparent indium tin oxide film, a solar energy regulating high radiation part is installed on the other side of the glass substrate, the solar energy regulating high radiation part comprises a first polyethylene layer, a hydroxypropyl cellulose hydrogel layer is installed on the upper part of the first polyethylene layer, the hydroxypropyl cellulose hydrogel layer is also installed with a second polyethylene layer, and the hydroxypropyl cellulose hydrogel layer is wrapped in the middle by the first polyethylene layer and the second polyethylene layer. The invention can dynamically adjust the thermal radiation and solar transmittance of different bands according to the changes of seasons and climate, so as to reduce the indoor temperature and save energy consumption, reduce the cooling load of the building in summer and reduce the heat loss in winter.

The present invention belongs to the technical field of sewage treatment, and discloses a long-acting slow-release sludge denitrifying flora regulating agent, a preparation method and an application thereof. The preparation method includes: uniformly mixing dolomite powder, hydroxylamine-O-sulfonic acid powder and ethylhydrazine oxalate powder to obtain a composite powder; mixing hydroxypropyl cellulose with an ethanol aqueous solution to obtain a sizing agent; mixing the composite powder and the sizing agent and preparing the long-acting slow-release sludge denitrifying flora regulating agent through a granulation technique. The agent of the present invention can be applied in the process of treating nitrogen-containing wastewater, and can quickly regulate the flora structure to realize the start-up and performance optimization of the nitrite-based sewage denitrification process.

The invention belongs to the technical field of metallurgical pellet adhesives, and particularly relates to a fine iron powder cold-pressed pellet adhesive and a preparation method thereof. The fine iron powder cold-pressed pellet adhesive comprises the following components in parts by mass: 4-12 parts of an inorganic component, 1-5 parts of an organic component and 0.1-1 part of a dispersing agent, wherein the inorganic component is prepared from the following raw materials in parts by mass: 1 to 15 parts of calcium bentonite, 1 to 20 parts of aluminum oxide, 1 to 10 parts of P2O5, 1 to 15 parts of sulphoaluminate cement, 1 to 10 parts of borax and 1 to 8 parts of fly ash; the organic component is prepared from the following raw materials in parts by mass: 1 to 6 parts of polyvinyl alcohol, 5 to 15 parts of water-based phenolic resin and 1 to 10 parts of modified hydroxy propyl cellulose. According to the adhesive disclosed by the invention, the wet strength, the cold strength and the hot strength of the cold-pressed pellets are remarkably improved.

The invention relates to a colla corii asini-concha haliotidis compound as well as a preparation method and application thereof, and belongs to the technical field of medicines and health-care products. The colla corii asini-concha haliotidis compound provided by the invention comprises the following components in parts by weight: a) 38-42 parts of colla corii asini; b) 15-25 parts of concha haliotidis; and c) 1-5 parts of an auxiliary material, wherein the auxiliary material is selected from one or more of polyvinylpyrrolidone, copovidone, hydroxy propyl cellulose and hydroxyethyl cellulose. The donkey-hide gelatin and concha haliotidis compound is prepared by using a hot melt extrusion technology, so that the smell, wettability, dispersity and other properties of the donkey-hide gelatin are obviously improved, and the donkey-hide gelatin compound shows a good effect in an osteoporosis rat model and a calcium-deficient mouse model. The preparation process is simple and controllable, and has a good market prospect.

The disclosure provides leather articles and a method for making leather articles comprising a substrate and a coating comprising a cellulose derivative having improved colorfastness to rubbing. The cellulose derivative may be methyl cellulose, ethyl cellulose, ethyl methyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethyl methyl cellulose, hydroxypropyl methyl cellulose, ethyl hydroxyethyl cellulose, cellulose acetate, cellulose triacetate, cellulose propionate, cellulose acetate propionate, cellulose acetate butyrate, microcrystalline cellulose, cellulose nitrate, or cellulose sulfate.

The present invention relates to an immediate release monolithic tablet comprising a) granules comprising Metformin or its pharmaceutically acceptable salt, hydroxypropyl cellulose and at least one more pharmaceutically acceptable excipient, and b) powder mixture consisting essentially of Empagliflozin or its pharmaceutically acceptable salts, low substituted hydroxypropyl cellulose and at least one diluent, wherein said immediate release monolithic tablet doesn't comprise copovidone. The said tablet has a desirable pharmacokinetic characteristic, favorable storage stability and comparative dissolution properties. The invention further relates to a process for the preparation of said pharmaceutical composition and use thereof as medicament in the treatment of diabetes.

A stable pharmaceutical composition for oral administration, comprising sitagliptin and dapagliflozin, wherein said active ingredients are substantially free of contact from each other. A process for the preparation of a stable pharmaceutical dosage form for oral administration, comprising: Step 1: Weigh sitagliptin hydrochloride monohydrate and Microcrystalline Cellulose and sieve; Step 2: Wet granulation Step 3: Drying the granules in fluid bed dryer; Step 4: Sizing the granules; Step 5: Weigh dapagliflozin base, lactose monohydrate, and sodium starch glycolate, premix them and sieve; Step 6: Mixing granules from step 4 with excipients from step 5; Step 7: Lubrication with magnesium stearate, and Step 8: Compression of the homogeneous powder obtained from step 7 under controlled humidity in mono-layer tablets in a rotary tabletting machine. An alternative process comprising the following steps: Step 1: Weigh sitagliptin hydrochloride monohydrate and Microcrystalline Cellulose and sieve; Step 2: Wet granulation Step 3: Drying the granules in fluid bed dryer; Step 4: Sizing the granules; Step 5: Weigh dapagliflozin base, lactose monohydrate, and hydroxypropylcellulose and sieve; Step 6: Dry granulation of second active ingredient and the intra-granular excipients of step 5 and mix; Step 7: Sizing the slugs or flakes obtained from step 6; Step 8: Pre-Mixing the granules from step 4 and step 7; Step 9: Weigh sodium starch glycolate and sieve; Step 10: Mixing; Step 11: Lubrication with magnesium stearate, and Step 12: Compression of the homogeneous powder obtained from step 11.

The application provides a detection method of hydroxypropyl cellulose in a povidone-containing preparation, and specifically comprises the following steps: (1) preparing a sample solution by pretreating a sample to be detected; (2) detecting the sample solution by using HPLC, wherein an evaporative light scattering detector or an electrospray detector is used as a detector, a C18 chromatographic column is used as a chromatographic column, the column temperature is 20-40 DEG C, water is used as a mobile phase A, methanol is used as a mobile phase B, the flow rate is 0.5 ml / min-1.5 ml / min, and gradient elution is adopted. The detection method has good specificity and peak type, can not only separate hydroxypropyl cellulose from povidone and other high-molecular auxiliary materials in a pharmaceutical preparation, accurately quantify the content of hydroxypropyl cellulose, but also effectively identify the model, and provides a good method for reverse analysis, component analysis, auxiliary material release detection of the pharmaceutical preparation.

The present application relates to the technical field of facial mask cloths, and specifically discloses a plant fiber air cotton facial mask cloth and a preparation method thereof. A plant fiber air cotton facial mask cloth is made of the following raw materials in parts by weight: 80-100 parts of plant fiber air cotton original cloth; 1.2-1.8 parts of sepiolite powder; 5-8 parts of hydroxypropyl cellulose; 2-4 parts of water-soluble plant gum; 10-20 parts of water; its preparation method is: after hydroxypropyl cellulose, water-soluble plant gum and water are stirred and mixed evenly, sepiolite powder is added, and stirring and mixing is continued to obtain a treatment liquid; then after the plant fiber air cotton original cloth is unfolded, the treatment liquid is evenly sprayed on the surface of the plant fiber air cotton original cloth, and hot air is blown during the spraying process. After drying after airing, the plant fiber air cotton facial mask cloth can be obtained. The plant fiber air cotton facial mask cloth of the present application, when used in combination with a facial mask liquid, can have a relatively outstanding and excellent water holding capacity in an environment with a higher temperature, thereby ensuring the stable and excellent performance of the functional ingredients in the facial mask liquid.

The present invention relates to the field of pharmaceutical formulations, and in particular to a fine granule and a preparation method therefor. The provided fine granule is a fine granule having core particles, a coating layer and an additional material layer. Hydroxypropyl cellulose and / or hydroxypropyl methylcellulose in a specific proportion are selected as a tackifier, and low-substituted hydroxypropyl cellulose is used as a disintegrating agent, so that the prepared fine granule has good particle compactness, disintegration performance and dissolution performance. An anti-adherent is homogenized during the preparation of the coating layer material, so that the prepared coating layer material has good anti-adhesion effect, and does not adhere in the particle coating process, thereby ensuring the integrity of the particles. A fluidized granulation coating machine is selected for preparation and coating of the core particles, thereby ensuring more uniform particle size distribution of the fine granule.

The invention provides a production process for improving dissolvability of hydroxypropyl cellulose, which comprises the following steps: step 1, raw material pretreatment: crushing and drying a cellulose raw material to obtain pretreated cellulose; 2, homogeneous dissolution: mixing the pretreated cellulose with an ionic liquid solvent, and dissolving under heating and stirring conditions to obtain a cellulose solution; step 3, alkalization reaction: adding an alkali catalyst into the cellulose solution, and reacting under a low-temperature condition to obtain alkalized cellulose; 4, etherification modification: adding an etherifying agent into the alkalized cellulose for etherification reaction to obtain a hydroxypropylation reaction solution; and 5, neutralizing and purifying, namely adjusting the pH value of the hydroxypropylation reaction solution, adding a precipitator to precipitate the product, and filtering, washing and drying to obtain the hydroxypropyl cellulose. Through optimization of a homogeneous reaction system and process conditions, uniform distribution of the hydroxypropyl substitution degree is realized at the molecular level, so that the dissolving property of the hydroxypropyl cellulose is remarkably improved.

The application provides an oral instant tablet containing Morinda citrifolia oil, which comprises the following components in parts by mass: Morinda citrifolia oil microemulsion 10 parts, carrier 30-40 parts, coating material 2-4 parts, and disintegrating agent 2-5 parts. The coating material is selected from Aeroperl and / or Sylysia; the carrier is selected from one or more of microcrystalline cellulose MCC PH101, microcrystalline cellulose MCC PH102, starch and lactose; and the disintegrating agent is selected from carboxymethyl starch sodium and / or low-substituted hydroxypropyl cellulose. The microemulsification technology is used to wrap the essential oil to reduce the volatilization of the essential oil; the microemulsion is made into a tablet to cover the acidity, increase the compliance of the public, and realize the form change of the Morinda citrifolia oil microemulsion from liquid to solid. The application studies and prepares the oral instant tablet containing Morinda citrifolia oil, which not only solves the inherent defects of traditional dosage forms, but also provides a more convenient taking mode compared with common tablets.

The invention provides a candesartan cilexetil capsule and a preparation method thereof, and the candesartan cilexetil capsule is characterized in that each capsule contains candesartan cilexetil, lactose, corn starch, hydroxypropyl cellulose, carboxymethyl cellulose calcium, polyethylene glycol 8000 and magnesium stearate. According to the candesartan cilexetil capsule provided by the invention, the problem of stability of candesartan cilexetil is solved, the possibility of crystal transformation of common tablets in a tabletting process is reduced, and the characteristic dissolution curve of a final product is similar to that of a reference preparation; the preparation method is simple in process route, the fluidized bed one-step granulation method enables the loss to be less, the product yield is higher, and the industrial mass production cost is reduced.

A cultivation method for improving the quality and yield of black fungus using hydrogen-rich water involves spraying a hydrogen-rich water composition three times during mycelial culture, spraying it every two days during primordium differentiation, and spraying it daily during fruiting body enlargement. The hydrogen-rich water composition comprises hydrogen-rich water, xylose, humic acid, gelatin, hydroxypropyl cellulose, and deionized water. This invention effectively solves the problems of poor hydrogen concentration stability and hydrogen volatilization in hydrogen-rich water by adding functional components such as gelatin, hydroxypropyl cellulose, xylose, and humic acid to the hydrogen-rich water, thus extending the time of hydrogen concentration stability and its effect. By using the above-mentioned hydrogen-rich water composition during the mycelial growth and primordium differentiation stages of black fungus, the microenvironment for black fungus growth is comprehensively optimized, resulting in increased yield, improved quality, and enhanced marketability. This provides an effective way to cultivate superior black fungus varieties.

A sublingual tablet and application thereof in desensitization therapy drug are provided. The sublingual tablet is a low-dose allergen sublingual tablet. The sublingual tablet includes freeze-dried powder of allergen protein, lactose, mannitol, low substituted hydroxypropyl cellulose, low moisture microcrystalline cellulose, and magnesium stearate. The freeze-drying process is adopted to obtain the freeze-dried powder of allergen protein, and the powder direct compression technology is adopted to obtain the sublingual tablet of allergen protein. The low-dose sublingual tablet has excellent properties, including appearance, hardness, tablet weight variation, disintegration time, taste, and uniformity of content, in particular has outstanding advantages in disintegration time, uniformity of content, stability, and preparation process, and has an industrial application prospect.

This application provides a modified cellulose thickener for fracturing fluid, fracturing fluid, and preparation method thereof, relating to the field of oil and gas extraction technology. This application utilizes a cellulose derivative obtained by grafting carboxymethyl cellulose with a biaminopolysiloxane as a thickener. Compared to hydroxypropyl cellulose and carboxymethyl cellulose, this cellulose derivative exhibits higher heat and shear resistance, good swelling properties, and low residue content, reducing damage to formations.