286 results about "Hydroxypropyl cellulose" patented technology

The invention relates to a cellulose-chitosan-based lithium ion battery diaphragm and a preparation method and application thereof.The preparation method of the diaphragm comprises the steps that gamma-polyglutamic acid and polyamide epichlorohydrin are adopted for modifying chitosan, the hydrophilicity and the liquid absorption capacity of the chitosan are improved, polyvinylpyrrolidone is adopted for coating the chitosan, and the hydrophilicity and the liquid absorption capacity of the chitosan are improved; pVP is replaced in ethanol soaking to form micropores, so that the porosity of the modified chitosan is improved. Amino groups and hydroxyl groups of the modified chitosan are combined with catechol of the polydopamine and hydroxyl groups of the hydroxy propyl cellulose through hydrogen bonds and covalent bonds to form a chitosan-cellulose-PDA interpenetrating network, and the diaphragm material suitable for the lithium ion battery is finally prepared by combining hot-pressing shaping. The preparation method has the advantages that the balance between the mechanical property and the ion conduction property of the diaphragm is realized through multi-component compounding by utilizing the biocompatibility and renewability of natural macromolecules (cellulose and chitosan).

The invention belongs to the field of food additives-compound coating agents and medicine solid preparation thin film coating premixing agents, and relates to a preparation method of a solid dispersion and a water-based gastric-soluble efficient moisture-proof coating composition containing the solid dispersion. According to the solid dispersion provided by the invention, stearic acid and magnesium stearate are selected as indissolvable components, polyglycerol fatty acid ester is used as a surfactant, hydroxypropyl methylcellulose / hydroxy propyl cellulose / sodium alginate is used as a carrier, and a grinding process is combined to treat the raw materials, so that a good synergistic effect is formed among the components; and the solid dispersion which can be stably amorphized is prepared. Tests find that the content of insoluble components in the prepared solid dispersion is obviously improved unexpectedly, and a coating composition of a carrier containing the solid dispersion has extremely excellent moisture resistance after film formation.

The invention discloses a preparation method and application of a high-sensitivity temperature-responsive cellulose-based structural color material, and belongs to the field of functional polymer materials. The preparation method comprises the following steps: adding an isopropanol solvent into a certain volume of aqueous solution to obtain an isopropanol dilute solution; hydroxypropyl cellulose is dissolved in an isopropanol dilute solution, a cholesteric liquid crystal structure is formed through self-assembly, a bright structural color is presented, and the hydroxy propyl cellulose structural color material is prepared. A hydroxy propyl cellulose structural color material is uniformly coated on the surface of a polydimethylsiloxane film containing carbon nanotubes, then the transparent polydimethylsiloxane film is used for sealing the hydroxy propyl cellulose structural color material, the temperature sensor with the visual structural color is prepared, and the temperature sensor with the visual structural color is attached to the skin of the human body and can display different colors along with temperature changes. The prepared structural color material is sensitive in response to temperature stimulation, rapid in color change and suitable for human body visual real-time temperature monitoring in the field of intelligent sensing.

The invention discloses a preparation method of thermochromic HPC / PEG hydrogel, which comprises the following steps: preparing an aqueous solution of hydroxy propyl cellulose (HPC), and slowly adding potassium persulfate (KPS) and a BIS initiator under a stirring condition to obtain HPC hydrogel; adding PEG (Polyethylene Glycol) into the HPC hydrogel, and carrying out ultrasonic mixing to obtain thermochromic HPC / PEG hydrogel; the molecular weight of the PEG is 400 to 20000; the mass percent of the PEG in the HPC / PEG hydrogel is 0 to 50 percent by weight; the thermochromic intelligent window is obtained by injecting the thermochromic HPC / PEG hydrogel between two pieces of quartz glass, then sealing the periphery and standing. By adding PEG with proper content and molecular weight, dual regulation and control of LCST and optical performance of the HPC hydrogel are realized, the problem that low response temperature and high solar modulation capability of the hydrogel cannot be achieved at the same time is solved, and the obtained HPC / PEG hydrogel has the characteristics of high transmittance, high solar modulation efficiency, low critical transition temperature and long cycle life.

The invention discloses a whitening composition as well as a preparation method and application thereof in a solid flash release soluble microneedle, and belongs to the technical field of cosmetics. The whitening composition is prepared from the following components in parts by weight: 0.2 to 0.4 part of tetrahydromagnolol, 1 to 2 parts of nonapeptide-1 and the like, and the tetrahydromagnolol and the nonapeptide-1 can synergistically generate a remarkable whitening effect; a microneedle skeleton prepared from the whitening composition comprises sodium hyaluronate, low-substituted hydroxy propyl cellulose and mannitol, and the prepared microneedle has excellent mechanical strength at 37 DEG C, can be subjected to solid flash release, and can achieve the effects of convenience in use, whitening and the like.

The invention discloses a method for preparing a hollow glass bead composite alumina aerogel material by a directional freezing method. The method comprises the following steps: 1, adding hollow glass beads into a hydroxy propyl cellulose solution to prepare a hollow glass bead suspension solution; 2, adding a silicon source into a calcium chloride aqueous solution, and adding the chopped alumina fibers and the hollow glass bead suspension solution to prepare emulsion gel; 3, directional freeze drying; and 4, heating to obtain the aerogel material. According to the preparation method, an emulsion-gel method is adopted, emulsion gel is taken as a soft substance matrix, and alumina fibers and hollow glass beads are combined through an ultrahigh-viscosity colloid and a structure rearrangement agent, so that the density, porosity and heat conductivity coefficient of the aerogel material are effectively regulated and controlled, and the aerogel material is endowed with flexibility while the mechanical strength of the aerogel material is improved; after high-temperature ablation, the material is stable in structure, low in heat conductivity coefficient, capable of isolating heat from passing at ultralow temperature and high temperature, simple in preparation process, low in cost, environmentally friendly and suitable for large-scale production.

The invention provides a sustained-release pellet containing gamma-aminobutyric acid, the sustained-release pellet comprises a pellet core and a coating layer wrapping the pellet core, the pellet core contains a physiologically active substance, and the physiologically active substance is gamma-aminobutyric acid; the pellet core comprises the following components in parts by weight: 15-40 parts of gamma-aminobutyric acid, 30-55 parts of a filling agent, 1-30 parts of a lubricating agent and 0.5-5 parts of an anti-caking agent; the filling agent comprises at least one of microcrystalline cellulose, powdery cellulose, starch and derivatives thereof, hydroxypropyl cellulose, hydroxypropyl methylcellulose, low-substituted hydroxypropyl cellulose, sugar or sugar alcohol and fruit and vegetable powder; the lubricant comprises at least one of talcum powder, magnesium stearate, stearic acid, glycerol and leucine; the anti-caking agent comprises at least one of magnesium carbonate, tricalcium phosphate, calcium hydrophosphate and silicon dioxide.

The invention belongs to the technical field of metallurgical pellet adhesives, and particularly relates to a fine iron powder cold-pressed pellet adhesive and a preparation method thereof. The fine iron powder cold-pressed pellet adhesive comprises the following components in parts by mass: 4-12 parts of an inorganic component, 1-5 parts of an organic component and 0.1-1 part of a dispersing agent, wherein the inorganic component is prepared from the following raw materials in parts by mass: 1 to 15 parts of calcium bentonite, 1 to 20 parts of aluminum oxide, 1 to 10 parts of P2O5, 1 to 15 parts of sulphoaluminate cement, 1 to 10 parts of borax and 1 to 8 parts of fly ash; the organic component is prepared from the following raw materials in parts by mass: 1 to 6 parts of polyvinyl alcohol, 5 to 15 parts of water-based phenolic resin and 1 to 10 parts of modified hydroxy propyl cellulose. According to the adhesive disclosed by the invention, the wet strength, the cold strength and the hot strength of the cold-pressed pellets are remarkably improved.

The invention relates to a colla corii asini-concha haliotidis compound as well as a preparation method and application thereof, and belongs to the technical field of medicines and health-care products. The colla corii asini-concha haliotidis compound provided by the invention comprises the following components in parts by weight: a) 38-42 parts of colla corii asini; b) 15-25 parts of concha haliotidis; and c) 1-5 parts of an auxiliary material, wherein the auxiliary material is selected from one or more of polyvinylpyrrolidone, copovidone, hydroxy propyl cellulose and hydroxyethyl cellulose. The donkey-hide gelatin and concha haliotidis compound is prepared by using a hot melt extrusion technology, so that the smell, wettability, dispersity and other properties of the donkey-hide gelatin are obviously improved, and the donkey-hide gelatin compound shows a good effect in an osteoporosis rat model and a calcium-deficient mouse model. The preparation process is simple and controllable, and has a good market prospect.

The application provides a detection method of hydroxypropyl cellulose in a povidone-containing preparation, and specifically comprises the following steps: (1) preparing a sample solution by pretreating a sample to be detected; (2) detecting the sample solution by using HPLC, wherein an evaporative light scattering detector or an electrospray detector is used as a detector, a C18 chromatographic column is used as a chromatographic column, the column temperature is 20-40 DEG C, water is used as a mobile phase A, methanol is used as a mobile phase B, the flow rate is 0.5 ml / min-1.5 ml / min, and gradient elution is adopted. The detection method has good specificity and peak type, can not only separate hydroxypropyl cellulose from povidone and other high-molecular auxiliary materials in a pharmaceutical preparation, accurately quantify the content of hydroxypropyl cellulose, but also effectively identify the model, and provides a good method for reverse analysis, component analysis, auxiliary material release detection of the pharmaceutical preparation.

The present application relates to the technical field of facial mask cloths, and specifically discloses a plant fiber air cotton facial mask cloth and a preparation method thereof. A plant fiber air cotton facial mask cloth is made of the following raw materials in parts by weight: 80-100 parts of plant fiber air cotton original cloth; 1.2-1.8 parts of sepiolite powder; 5-8 parts of hydroxypropyl cellulose; 2-4 parts of water-soluble plant gum; 10-20 parts of water; its preparation method is: after hydroxypropyl cellulose, water-soluble plant gum and water are stirred and mixed evenly, sepiolite powder is added, and stirring and mixing is continued to obtain a treatment liquid; then after the plant fiber air cotton original cloth is unfolded, the treatment liquid is evenly sprayed on the surface of the plant fiber air cotton original cloth, and hot air is blown during the spraying process. After drying after airing, the plant fiber air cotton facial mask cloth can be obtained. The plant fiber air cotton facial mask cloth of the present application, when used in combination with a facial mask liquid, can have a relatively outstanding and excellent water holding capacity in an environment with a higher temperature, thereby ensuring the stable and excellent performance of the functional ingredients in the facial mask liquid.

The invention provides a production process for improving dissolvability of hydroxypropyl cellulose, which comprises the following steps: step 1, raw material pretreatment: crushing and drying a cellulose raw material to obtain pretreated cellulose; 2, homogeneous dissolution: mixing the pretreated cellulose with an ionic liquid solvent, and dissolving under heating and stirring conditions to obtain a cellulose solution; step 3, alkalization reaction: adding an alkali catalyst into the cellulose solution, and reacting under a low-temperature condition to obtain alkalized cellulose; 4, etherification modification: adding an etherifying agent into the alkalized cellulose for etherification reaction to obtain a hydroxypropylation reaction solution; and 5, neutralizing and purifying, namely adjusting the pH value of the hydroxypropylation reaction solution, adding a precipitator to precipitate the product, and filtering, washing and drying to obtain the hydroxypropyl cellulose. Through optimization of a homogeneous reaction system and process conditions, uniform distribution of the hydroxypropyl substitution degree is realized at the molecular level, so that the dissolving property of the hydroxypropyl cellulose is remarkably improved.

The application provides an oral instant tablet containing Morinda citrifolia oil, which comprises the following components in parts by mass: Morinda citrifolia oil microemulsion 10 parts, carrier 30-40 parts, coating material 2-4 parts, and disintegrating agent 2-5 parts. The coating material is selected from Aeroperl and / or Sylysia; the carrier is selected from one or more of microcrystalline cellulose MCC PH101, microcrystalline cellulose MCC PH102, starch and lactose; and the disintegrating agent is selected from carboxymethyl starch sodium and / or low-substituted hydroxypropyl cellulose. The microemulsification technology is used to wrap the essential oil to reduce the volatilization of the essential oil; the microemulsion is made into a tablet to cover the acidity, increase the compliance of the public, and realize the form change of the Morinda citrifolia oil microemulsion from liquid to solid. The application studies and prepares the oral instant tablet containing Morinda citrifolia oil, which not only solves the inherent defects of traditional dosage forms, but also provides a more convenient taking mode compared with common tablets.

The invention provides a candesartan cilexetil capsule and a preparation method thereof, and the candesartan cilexetil capsule is characterized in that each capsule contains candesartan cilexetil, lactose, corn starch, hydroxypropyl cellulose, carboxymethyl cellulose calcium, polyethylene glycol 8000 and magnesium stearate. According to the candesartan cilexetil capsule provided by the invention, the problem of stability of candesartan cilexetil is solved, the possibility of crystal transformation of common tablets in a tabletting process is reduced, and the characteristic dissolution curve of a final product is similar to that of a reference preparation; the preparation method is simple in process route, the fluidized bed one-step granulation method enables the loss to be less, the product yield is higher, and the industrial mass production cost is reduced.

A cultivation method for improving the quality and yield of black fungus using hydrogen-rich water involves spraying a hydrogen-rich water composition three times during mycelial culture, spraying it every two days during primordium differentiation, and spraying it daily during fruiting body enlargement. The hydrogen-rich water composition comprises hydrogen-rich water, xylose, humic acid, gelatin, hydroxypropyl cellulose, and deionized water. This invention effectively solves the problems of poor hydrogen concentration stability and hydrogen volatilization in hydrogen-rich water by adding functional components such as gelatin, hydroxypropyl cellulose, xylose, and humic acid to the hydrogen-rich water, thus extending the time of hydrogen concentration stability and its effect. By using the above-mentioned hydrogen-rich water composition during the mycelial growth and primordium differentiation stages of black fungus, the microenvironment for black fungus growth is comprehensively optimized, resulting in increased yield, improved quality, and enhanced marketability. This provides an effective way to cultivate superior black fungus varieties.

A sublingual tablet and application thereof in desensitization therapy drug are provided. The sublingual tablet is a low-dose allergen sublingual tablet. The sublingual tablet includes freeze-dried powder of allergen protein, lactose, mannitol, low substituted hydroxypropyl cellulose, low moisture microcrystalline cellulose, and magnesium stearate. The freeze-drying process is adopted to obtain the freeze-dried powder of allergen protein, and the powder direct compression technology is adopted to obtain the sublingual tablet of allergen protein. The low-dose sublingual tablet has excellent properties, including appearance, hardness, tablet weight variation, disintegration time, taste, and uniformity of content, in particular has outstanding advantages in disintegration time, uniformity of content, stability, and preparation process, and has an industrial application prospect.

This application provides a modified cellulose thickener for fracturing fluid, fracturing fluid, and preparation method thereof, relating to the field of oil and gas extraction technology. This application utilizes a cellulose derivative obtained by grafting carboxymethyl cellulose with a biaminopolysiloxane as a thickener. Compared to hydroxypropyl cellulose and carboxymethyl cellulose, this cellulose derivative exhibits higher heat and shear resistance, good swelling properties, and low residue content, reducing damage to formations.

The invention provides a glucosamine hydrochloride capsule and a preparation method thereof, the capsule content comprises the following components in parts by weight: 240 parts of glucosamine hydrochloride, 50-60 parts of starch and 2-7 parts of hydroxypropyl cellulose; the glucosamine hydrochloride capsule prepared by controlling the particle sizes of the glucosamine hydrochloride and the starch within a specific range and using a specific adhesive is high in dissolution rate (the dissolution rate in four dissolution media for 45 minutes is not lower than 85%), and the dissolution rate is stable after the glucosamine hydrochloride capsule is placed for 24 months for a long time.

To provide a method for producing low-substituted hydroxypropyl cellulose having favorable disintegratability while maintaining sufficient compactibility.SOLUTION: A method for producing low-substituted hydroxypropyl cellulose having a hydroxypropoxy group content of 5 to 16 mass%, at least includes the steps of: bringing pulp into contact with and alkali metal hydroxide solution to obtain alkali cellulose; reacting the alkali cellulose with propylene oxide to obtain a reaction product; dispersing the reaction product into water containing at least acid to partially solubilize the reaction product, and then neutralizing the reaction product with an additional amount of acid to precipitate crude low-substituted hydroxypropyl cellulose; using a screw press to remove liquid from the crude low-substituted hydroxypropyl cellulose to obtain purified low-substituted hydroxypropyl cellulose having a water content of 50 to 60 mass%; and drying and pulverizing the purified low-substituted hydroxypropyl cellulose.SELECTED DRAWING: None

A pharmaceutical composition that contains an active ingredient having an ester bond, and at least one binder selected from the group consisting of polyvinyl alcohol, hydroxypropyl cellulose, and microcrystalline cellulose, wherein the active ingredient is a compound represented by formula (1) or a pharmaceutically acceptable salt thereof.

The invention belongs to the field of contact lens care, and particularly relates to a sandwich effervescent tablet for cleaning contact lenses and a preparation method of the sandwich effervescent tablet. The outer layer is prepared from the following raw materials: citric acid, sodium bicarbonate, disodium ethylene diamine tetraacetate, a surfactant, polyvinylpyrrolidone, microcrystalline cellulose and colloidal silicon dioxide; the middle layer is prepared from the following raw materials in parts by weight: sodium percarbonate, tetraacetylethylenediamine, phosphate buffer salt, a surfactant, anhydrous sodium carbonate, microcrystalline cellulose and colloidal silicon dioxide; the inner core is prepared from the following raw materials in parts by weight: catalase, a stabilizer, hydroxy propyl cellulose K4M, ethyl cellulose, microcrystalline cellulose and sodium bicarbonate. According to the invention, citric acid / bicarbonate is matched with an active agent to weaken a biological membrane in the outer layer, and a permeation channel is opened preferentially; the H2O2 platform is formed by matching middle-layer sodium percarbonate; and the inner core adopts HPMC / EC controlled-release catalase to realize hysteresis-burst release neutralization.

The present application relates to the technical field of pharmaceutical preparation, and provides a calcium carbonate tablet, which comprises the following raw materials in parts by weight: 700-800 parts of calcium carbonate, 80-100 parts of corn starch, 15-25 parts of low-substitution hydroxypropyl cellulose, 1.5-2.5 parts of polysorbate-80, 7-9 parts of protein sugar, 3-5 parts of hypromellose, 2.5-3.0 parts of magnesium stearate and 15-25 parts of sodium carboxymethyl starch; wherein the calcium carbonate is selected from calcium carbonate with a particle size of 40-80 μm; the low-substitution hydroxypropyl cellulose and the sodium carboxymethyl starch are disintegrants, and the ratio of the amount of the low-substitution hydroxypropyl cellulose to that of the sodium carboxymethyl starch is 1:1. The present application also provides a preparation method of the calcium carbonate tablet. The calcium carbonate tablet has the advantages of short disintegration time, high dissolution rate, good bioavailability and good stability.

This invention provides a drug for antagonizing bacterial endotoxins, its preparation method, and its application, belonging to the biomedical field. The composition consists of 25-55 parts of dried powdered traditional Chinese medicine extract, 25-70 parts of mixed essential oil powder, and 40-90 parts of lentinan powder. The traditional Chinese medicine extract is prepared by decoction of Scutellaria baicalensis, Lonicera japonica, Forsythia suspensa, and Isatis indigotica under reduced pressure at low temperature and spray drying. The mixed essential oil powder is prepared by encapsulating peppermint oil and eucalyptus oil with gelatin and hydroxypropyl cellulose and then spray drying under high pressure. This invention, through specific formulation and processing, significantly enhances the synergistic antagonistic effect of each component against endotoxins. Experiments show that this composition exhibits antagonistic activity far superior to ibuprofen in vitro; in vivo, it significantly reduces the endotoxin content in the plasma of 817 broiler chickens, rapidly alleviates LPS-induced fever and diarrhea, and improves decreased growth performance. Therefore, this invention is of great significance for reducing antibiotic dependence and improving the efficiency of livestock and poultry farming.

The present invention relates to a dry granulation process for preparing a solid pharmaceutical composition comprising Tenofovir alafenamide or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients, and its use in the treatment of for the treatment of chronic hepatitis B (CHB). The pharmaceutical composition comprises at least a disintegrant as pharmaceutical acceptable excipient for increasing the stability of the Tenofovir alafenamide and tablet coating material comprising hypromellose and hydroxypropyl cellulose, thus surprisingly improved impurity values and also improved dissolution profile has been obtained.

The present disclosure provides oral dosage forms comprising about 8.75% w / w deuruxolitinib phosphate, about 50% to about 60% w / w microcrystalline cellulose, about 25% to about 35% w / w lactose monohydrate, about 3% to about 6% w / w polyvinylpyrrolidone, about 2% to about 4% w / w hydroxypropyl cellulose, about 0.25% to about 0.75% w / w colloidal silicon dioxide, and about 0.25% to about 0.75% w / w magnesium stearate.

The invention discloses a preservative film agent and a preparation method thereof, and belongs to the technical field of preservation. The preservative film agent comprises the following raw materials: polyvinyl alcohol, hydroxy propyl cellulose, glycerol and an antibacterial agent, wherein the antibacterial agent is a cinnamyl aldehyde-loaded Pickering emulsion; a Pickering emulsion is dispersed in a PVA / HPC composite film agent, and a solvent pouring method is adopted to prepare the composite film with antibacterial performance. According to the invention, polyvinyl alcohol and hydroxy propyl cellulose are selected to form a film together so as to overcome the defects of a traditional film agent, and the cinnamyl aldehyde-loaded Pickering emulsion is dispersed in a composite film agent prepared from PVA / HPC, so that the comprehensive preservative film agent with good preservation effect and antibacterial ability is obtained.

The invention belongs to the technical field of high polymer materials, and particularly discloses a bio-based fireproof hydrogel material and a preparation method thereof, the bio-based fireproof hydrogel material comprises the following components by weight: 3-3.5 parts of carboxymethyl chitosan, 2-2.5 parts of hydroxy propyl cellulose, 11-11.5 parts of silica sol, 82.5-83.5 parts of water, and 0.1-0.3 part of genipin. According to the bio-based fireproof hydrogel material and the preparation method thereof disclosed by the invention, the material prepared by the method realizes efficient fire prevention through a triple synergistic mechanism of heat absorption and cooling, gas phase inhibition and condensed phase barrier, and can provide a protected object with a fireproof aging of more than 5 minutes under flame of 600-800 DEG C, which is obviously superior to that of the traditional hydrogel; in addition, the material prepared by the method is non-toxic, low in cost and suitable for the fields of buildings, forest fire prevention and the like.

Gummy or jelly candies with modified functional ingredients with controlled time-release. The invention relates to gummy or jelly candies (1) comprising at least one modified functional ingredient with controlled time-release, characterized in that they comprise, inside or on the surface, at least one modified functional ingredient (2), namely encapsulated and / or granulated, said gummy or jelly candies having the following constituents: at least one carbohydrate consisting of glucose syrup and / or sugar; at least one fiber; at least one protein; and at least one fruit in the form of concentrated juice or natural juice and / or at least one natural or artificial sweetener; at least one gelling agent; at least one flavoring; at least one coloring; said at least one modified functional ingredient which is a food functional ingredient; water;and at least one acid, the constituent (E) comprising an active substance or a functional ingredient proper (3) and an excipient, and being disposed of in capsules or granules (4), the excipient being a microencapsulation excipient in the case of capsules or a granulation excipient in the case of granules, said excipient being at least one of: glyceryl dibehenate, hydroxypropyl cellulose and / or ethyl cellulose, a constituent (E) having an excipient proportion of between 20 and 80% by weight.;

The invention discloses a preparation method for prolonging the validity period of erythromycin ethylsuccinate orally disintegrating tablets. The preparation method comprises the following steps: sequentially putting low-substituted hydroxypropyl cellulose, microcrystalline cellulose, aspartame, carboxymethyl starch sodium and polyvinylpolypyrrolidone into a wet granulation mixer, covering with a cover, starting equipment, carrying out low-speed dry mixing for 3 minutes, slowly adding low-concentration hydroxypropyl methylcellulose slurry from a feed port of a pot cover, and carrying out low-speed wet mixing for 3 minutes; stopping the machine, opening the cover, scraping powder on the inner surface of the pot cover and the periphery of the inner side of the pot by using a clean scraper, adding erythromycin ethylsuccinate raw materials, covering the cover, starting equipment, carrying out low-speed wet mixing for 3 minutes, and carrying out high-speed wet mixing for 2 minutes. By improving the medicine production process, the stability and durability of the medicine are improved, so that the validity period of the medicine is prolonged, and meanwhile, the effectiveness and safety of the medicine can still be kept within the prolonged validity period.

The present invention relates to a kind of dexmedetomidine hydrochloride orally disintegrating film, in which the orally disintegrating film contains dexmedetomidine hydrochloride 0.1-10% and film-forming material 90%-99.9% by weight, wherein the film-forming material is selected from any one of copolyvidone, polyethylene caprolactam polyvinyl acetate polyethylene glycol graft copolymer, hydroxypropyl methylcellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, polyvinyl alcohol, polyoxyethylene, povidone, and poloxamer or a combination thereof. The dexmedetomidine hydrochloride orally disintegrating film of the present invention has fast disintegration time in the oral cavity, good mechanical extrusion performance, good film-forming performance, high content uniformity, meets the requirements such as cutting, packaging, transportation and clinical use, significantly improves its dissolution and dissolution rate, stability and bioavailability, and does not need to be taken with water, significantly improves the compliance of children patients, and ensures safe and effective medication.