1812 results about "Saponin" patented technology

The invention discloses fermented lactobacillus mucus NJ-10 and application thereof in preparation of rare ginsenoside-rich metagen through fermentation conversion, and relates to the field of probiotic fermentation. The lactobacillus fermentum NJ-10 is preserved in the China Center for Type Culture Collection on February 25, 2025, and the preservation number of the lactobacillus fermentum NJ-10 is CCTCC (China Center for Type Culture Collection) NO: M 2025300. According to the present invention, the fermentation lactobacillus mucus NJ-10 capable of producing beta-glucosidase, which is subjected to autonomous separation and identification, can be used for fermentation and conversion of ginseng stem and leaf saponin, and then is subjected to post-generation preparation in a high-temperature and high-pressure steam manner, such that the beta-glucosidase producing beta-glucosidase can be produced, and the beta-glucosidase producing beta-glucosidase producing beta-glucosidase producing beta-glucosidase producing beta-glucosidase producing beta-glucosidase can be produced. According to the method, ginseng stem and leaf saponin is converted through two-step fermentation to prepare the postbiotic fermentation product rich in rare ginsenoside, resource utilization of non-medicinal parts of ginseng is expanded, and the postbiotic fermentation product has wide application prospects in the fields of food industry, pharmaceutical industry, cosmetics, animal breeding and the like.

The invention discloses a ginseng extract rich in rare saponins and preparation and anti-aging application thereof, and belongs to the technical field of oral beauty and skin care products, the ginseng extract is obtained by fermentation treatment of ginseng powder through phytobacterium plantarum, and the preservation number of the phytobacterium plantarum is GDMCC No.64374. The ginseng extract rich in rare saponin is fermented by specific plant lactobacillus, ginsenoside is efficiently converted into CK and F1, various natural plant components such as ginseng polysaccharide are reserved, and a specific synergistic effect is generated. Through verification, the prepared ginseng extract is high in bioavailability, can more effectively inhibit cell inflammation, and can more effectively recover the mitochondrial function of senescent cells and inhibit cell senescence. The preparation method provided by the invention is high in operability and easy to standardize and intellectualize. Compared with a traditional extraction and purification method, the adopted fermentation method is more environmentally friendly and efficient, and large-scale production can be achieved in industrial production.

The invention provides a red ginseng processing method capable of increasing the content of rare ginsenoside and reducing pesticide residues, and relates to the technical field of medicinal material processing, the red ginseng processing method comprises the following steps: A, steaming fresh ginseng by using atomized probiotic fermentation liquor; b, drying the steamed fresh ginseng to obtain red ginseng; the pH (Potential of Hydrogen) of the probiotic fermentation liquor is 3.0 to 4.0; the OD600 value of the probiotic fermentation liquor is 1.2-2.5, the probiotic fermentation liquor is obtained through probiotic fermentation, the fermentation liquor with the pH value being 3.0-4.0 is adopted as an acid catalyst to replace purified water, in the ginseng steaming process, steaming is conducted through the atomized probiotic fermentation liquor, conversion of ginsenoside is promoted, and meanwhile organophosphorus pesticide residues in ginseng are degraded. The method is safe, efficient, green and natural, and loss of nutritional ingredients and functional ingredients caused by cooking is avoided. The technical problems that red ginseng processed and prepared in the prior art is low in rare saponin content and poor in effect and pesticide residues exist are solved.

The invention discloses pulsatilla saponin B4-oleanolic acid self-assembled nanoparticles as well as preparation and application thereof, and relates to the technical field of pharmaceutical preparations. Inspired by compatibility and solubilization of traditional Chinese medicines, the pulsatilla saponin B4-oleanolic acid self-assembled nanoparticles (AB4-OA NPs) are prepared by taking natural active components, namely micromolecular pulsatilla saponin B4 and oleanolic acid, as raw materials; the oleanolic acid has the effects of promoting dissolution and resisting inflammation, the water solubility of the oleanolic acid is improved, the bioavailability is improved, and the anti-inflammatory effect of the oleanolic acid is enhanced. Experimental results show that the AB4-OA NPs can effectively improve the dissolution rate of the oleanolic acid, so that the bioavailability of the oleanolic acid is effectively improved, meanwhile, the AB4-OA NPs has a better anti-inflammatory effect, and the effect is better than that of a single drug with the same dosage. In addition, the synthetic preparation method is simple and convenient, has the advantages of nano-scale drugs, realizes auxiliary-material-free pure drug self-delivery, and improves the delivery efficiency.

The invention provides a combined fermented product of ginseng, astragalus membranaceus and donkey-hide gelatin as well as a preparation method and application of the combined fermented product, and relates to the technical field of pharmaceutical preparations. The combined leavening is obtained by fermenting ginseng, astragalus membranaceus and donkey-hide gelatin, and the mass ratio of the ginseng to the astragalus membranaceus to the donkey-hide gelatin is (1-3): (10-30): 1. The composition of ginseng, astragalus membranaceus and colla corii asini is subjected to probiotic fermentation, macromolecular saponin is converted into aglycone or secondary saponin with smaller molecules, protein is split into peptide chains with smaller molecules, polysaccharide is split into sugar chains with smaller molecules, absorption and utilization of effective components of the medicine are facilitated, and the effect of tonifying qi and blood can be rapidly achieved.

The present invention relates to a method for producing a transgenic plant having an increased saponin content. It is confirmed that a nucleotide having a base sequence represented by SEQ ID NO: 1 or 2 derived from ginseng Panax ginseng increases ginsenoside accumulation by regulating the expression of genes involved in ginsenoside biosynthesis. Therefore, the method can be advantageously applied to the production of transgenic plants with increased saponin content.

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention provides a method for synchronously extracting tea seed oil and tea saponin from tea seeds, and belongs to the technical field of active substance extraction. According to the method, the extraction rate and the purity are remarkably improved by finely regulating and controlling the extraction conditions. The specific composite oil extraction auxiliary agent and the ultrasonic-assisted extraction technology are adopted, and the power, time and solvent ratio are optimized, so that the extraction efficiency and the product quality of the tea seed oil and the tea saponin are superior to those of the tea seed oil and the tea saponin prepared by a traditional method. Experimental data prove that the extraction rate of the tea seed oil reaches 27.22%, and the purity of the tea seed oil reaches 99.66%; the extraction rate of the tea saponin is 21.85%, and the purity of the tea saponin reaches 96.50%. By increasing the utilization rate of the raw materials and reducing the production cost, the market competitiveness of the product is improved, the high-quality tea seed oil and tea saponin meet the requirements of the market for natural products, and the tea seed oil and tea saponin have wide application prospects.

The invention discloses a plant-source nutritional supplement based on glycoside compounds and a preparation method thereof, and relates to the technical field of preparation of plant-source nutritional supplements.The preparation method comprises the steps that raw materials are prepared; the preparation method comprises the following steps: respectively carrying out ultrasonic-assisted extraction on flavonoid glycoside, saponin and geniposide raw materials to obtain an extracting solution; carrying out centrifugal separation on the extracting solution, taking supernate, and then purifying by adopting a macroporous resin adsorption method to obtain a purified glycoside compound solution; mixing the purified glycoside compound solution with lycium barbarum polysaccharide, Chinese yam starch, vitamin E and other auxiliaries in proportion, and uniformly stirring to form a mixed solution; carrying out spray drying on the mixed solution to obtain a powdery nutritional supplement; and screening the powdery nutritional supplement. The high-purity plant source glycoside compound and the functional auxiliary agent are scientifically compounded, and ultrasonic extraction, resin purification and precise process control are combined, so that the integrated improvement of activity synergy, quality stability and personalized scene adaptation of the nutritional supplement is realized.

The invention belongs to the technical field of medicine and health care, and particularly relates to a preparation method of an American ginseng root water extract rich in rare ginsenoside and application of the American ginseng root water extract in improving the immune and anti-tumor direction. The preparation method comprises the following steps: step 1, carrying out superfine grinding on American ginseng, and sieving; step 2, adding the American ginseng powder into water, and then adding compound enzyme for enzymolysis to obtain enzymatic hydrolysate; s3, after the enzymolysis is finished, heating the enzymatic hydrolysate, extracting twice, and mixing after the extraction is finished; and S4, inoculating compound lactic acid bacteria into the mixed solution, fermenting to obtain a fermentation solution, blending, and sterilizing to obtain the American ginseng afterbiogen beverage. According to the invention, a new physical-biological combined process is adopted, and crushing, enzymolysis, extraction, fermentation and blending are carried out, so that the American ginseng metagen beverage rich in rare ginsenoside is obtained, and the rare ginsenoside has a remarkable anti-tumor effect and higher activity.

The invention relates to a method for constructing HPLC (High Performance Liquid Chromatography) contents of multi-index components of a reference sample of traditional Chinese medicine powder, which comprises the following steps: step 1, preparation of a reference sample of Kaixin powder: taking polygala tenuifolia, ginseng, poria cocos and rhizoma acori graminei, and crushing into fine powder; 2, preparing a Kaixin powder reference sample and a reference substance detection solution; 3, detecting the Kaixin powder reference sample and the reference substance detection liquid by adopting an HPLC (High Performance Liquid Chromatography) instrument to obtain a chromatogram; and step 4, calculating the content of the effective components in the Kaixin powder reference sample according to the chromatogram. Wherein in the step 3, an HPLC (High Performance Liquid Chromatography) instrument is adopted for detection, and a chromatogram is obtained; comprising the following steps: step A, detecting the contents of polygala # imgabs0 # ketone III, 3, 6 '-dimustard acyl sucrose and beta-asarone in rhizoma acori graminei in polygala tenuifolia; step B, detecting the contents of ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 in the ginseng; and step C, detecting the content of tenuifolin in the polygala tenuifolia.

The invention belongs to the technical field of plant genetic engineering, and particularly relates to application of a centella asiatica glycosyl transferase gene in catalyzing glycosylation of asiatic acid and madecassic acid. The nucleotide sequence of the gene is shown as SEQ ID No.1, and the protein coded by the gene can catalyze the C-28 site of asiatic acid and madecassic acid to perform glucose group modification so as to generate asiatic acid monoglucoside and madecassic acid monoglucoside, and preferentially catalyzes madecassic acid. By constructing a metabolic regulation network, the genes are widely and accurately screened, and the glycosylation process of catalyzing asiatic acid and madecassic acid is analyzed; an important reference basis is provided for improving the glycosylation efficiency of asiatic acid and madecassic acid and the yield of asiaticoside and madecassoside in the in-vitro synthesis and industrial production process of the centella asiatica triterpenoid saponin, and an important theoretical support is provided for large-scale production of the centella asiatica active saponin.

The invention relates to a ligand-effector moiety provided with at least one saponin and antibody-effector moiety provided with at least one saponin. An aspect of the invention is a composition comprising the ligand-effector moiety provided with at least one saponin or the antibody-effector moiety provided with at least one saponin of the invention. The invention also relates to an antibody-drug conjugate comprising covalently linked saponin and to an antibody-oligonucleotide conjugate comprising covalently linked saponin. An aspect of the invention relates to a pharmaceutical composition comprising the ligand-effector moiety provided with at least one saponin or the antibody-effector moiety provided with at least one saponin of the invention, and optionally further comprising a pharmaceutically acceptable excipient. The invention also relates to the ligand-effector moiety provided with at least one saponin or the antibody-effector moiety provided with at least one saponin, for use as a medicament. The invention also relates to the ligand-effector moiety provided with at least one saponin or the antibody-effector moiety provided with at least one saponin of the invention for use in the treatment or prophylaxis of a cancer.

The embodiment of the invention provides a method for regulating and controlling the form of ginseng adventitious roots and saponin accumulation. The method comprises the following steps: (a) carrying out mutagenesis treatment on initial ginseng adventitious roots by using ethyl methane sulfonate (EMS); (b) performing multiple rounds of screening and subculture to obtain to-be-selected ginseng adventitious roots with different forms and saponin accumulation; and (c) determining one or more target genes for regulating and controlling the form of the ginseng adventitious root and saponin accumulation based on the ginseng adventitious root to be selected.

The invention relates to a method for producing notoginsenoside and ginsenoside by utilizing panax notoginseng cotyledon embryos, and belongs to the technical field of plant adventitious root tissue culture. The method comprises the following steps: inducing embryogenic calluses by utilizing immature zygotic embryos of panax notoginseng; proliferating the panax notoginseng embryogenic callus on a plate culture medium; s2, putting the pseudo-ginseng embryogenic callus obtained in the step S2 into a liquid culture medium, carrying out cell dispersion, and sieving by using a sieve with the aperture of 24-30 meshes; a mechanical stirring type bioreactor is filled with a liquid culture medium, and the globular embryo and the heart-shaped embryo are placed in the mechanical stirring type bioreactor to be cultured; s3, recovering the filtrate in the step S3, filtering by using a screen with the aperture of 30-80 meshes and 80-150 meshes to obtain uniform panax notoginseng embryogenic cells, and differentiating the panax notoginseng embryogenic cells in a triangular flask for the step S4; and drying the cotyledon embryo obtained in the step S4 at 45 DEG C, and grinding into powder. According to the method, large-scale generation of cotyledon embryos can be completed only in 4-6 weeks, the production process is remarkably accelerated, the method is suitable for industrial batch production requirements, and the production efficiency is high.

A method for improving health conditions of mammals or livestock by feeding, to the mammals or livestock, a licorice extract including: (A) glycyrrhizic acid, a glycyrrhizic acid derivative, glycyrrhetinic acid, and / or a glycyrrhetinic acid derivative; (B) licorice saponins other than (A); and (C) licorice flavonoids; (B) including at least a licorice saponin H2, a licorice saponin G2, and macedonoside A, (C) including at least liquiritin apioside, isoliquiritin apioside, and isoliquiritin, where feeding is of 0.017 g / day / head or more of the licorice saponin H2, 0.002 g / day / head or more of the licorice saponin G2, and 0.002 g / day / head or more of the macedonoside A, 0.001 g / day / head or more of the liquiritin apioside, 0.001 g / day / head or more of the isoliquiritin apioside, and 0.001 g / day / head or more of the isoliquiritin.

The invention relates to a medicine for repairing skin wounds and a preparation method thereof, and belongs to the technical field of biological medicines.The medicine is prepared from, by mass, 25-30 parts of bee embryo peptide, 8-10 parts of alkannin derivative, 10-15 parts of armillaria mellea polysaccharide, 8-10 parts of inonotus obliquus polysaccharide, 6-8 parts of notoginsenoside and 5-7 parts of astragaloside. The bee fetus peptide is a product which is more than 500Da and is obtained by performing step-by-step enzymolysis on bee larva freeze-dried powder through trypsin and bacillus subtilis neutral protease to obtain enzymatic hydrolysate which is less than 3kDa, performing purification through a G-50 sephadex column, performing ultrafiltration and performing freeze-drying. The alkannin derivative is obtained by reacting alkannin with succinic anhydride and glucosamine-polyethylene glycol. A special method is adopted for preparing the bee embryo peptide and alkannin derivatives, the bee embryo peptide and alkannin derivatives are matched with other components to play a synergistic role, and the effects of high safety, high skin cell proliferation promoting capacity, excellent antibacterial performance and the like are achieved.

The invention belongs to the technical field of biological medicine, and particularly relates to red ginseng fermentation broth and a preparation method and application thereof.The preparation method of the red ginseng fermentation broth comprises the following steps that red ginseng powder is dissolved in water, and a red ginseng fermentation medium is obtained by breaking cell walls in red ginseng; mixing the seed solution of the plant lactobacillus and the seed solution of the fermentation mucus lactobacillus to obtain a compound strain seed solution; inoculating the compound strain seed solution into a red ginseng fermentation culture medium for fermentation culture to obtain a fermentation solution; centrifuging the fermentation liquor, collecting supernate, extruding and filtering the supernate, and collecting filtrate, so as to obtain the red ginseng fermentation liquor. According to the invention, compound strain fermentation is adopted, and a mechanical extrusion mode is combined to increase the content of total saponins of ginseng. According to the method disclosed by the invention, the concentration of the total saponins of ginseng is increased from 2.19 mg / mL to 7.53 mg / mL.

The invention discloses a bone joint repairing composition containing stem cell vesicles and application of the bone joint repairing composition, and relates to the technical field of bone joint repairing compositions.The bone joint repairing composition is prepared from, by weight, 90-110 parts of stem cell vesicles and 41-57 parts of thelenota ananas saponin Ananaside A. The stem cell vesicles and the thelenota ananas saponin Ananaside A are combined to form the bone joint repairing composition. The stem cell vesicles are extracellular vesicles derived from human amniotic mesenchymal stem cells. According to the bone joint repairing composition provided by the invention, the stem cell vesicles and the thelenota ananas saponin in a proper proportion are matched for use, so that the synergistic interaction between the stem cell vesicles and the thelenota ananas saponin is realized. Animal experiments show that the composition has a remarkable repairing effect on a rat model with bone and joint injuries, can effectively relieve bone and joint pain symptoms of rats, not only widens the application field of human amniotic mesenchymal stem cell-derived extracellular vesicles, but also provides a new clinical treatment means for bone and joint repairing.

The invention discloses a novel herpes zoster vaccine composition and a preparation method, and belongs to the technical field of vaccines. The novel herpes zoster vaccine composition comprises gE protein and an adjuvant, the adjuvant is selected from at least one of an aluminum salt adjuvant, a saponin adjuvant, a TLR pathway agonist, an STING pathway agonist, an emulsion adjuvant and a liposome adjuvant. The invention also provides a preparation method of the composition. Compared with the prior art, the gE protein prepared by the method disclosed by the invention has the advantages that a protective matrix is jointly constructed by saccharides capable of forming a glassy state and a buffer system, and conformation is fixed through hydrogen bond replacement and vitrification in freezing and drying processes, so that interface-induced folding and aggregation are reduced; a small amount of surfactant weakens air-liquid and solid-liquid interfacial tension, terminal low-adsorption filtration reduces non-specific adsorption loss, and the monomer state and immunogenicity are maintained after redissolution.

The embodiment of the invention provides a method for converting ginsenoside in ginseng adventitious roots, which comprises the following steps: (a) taking liquid-cultured ginseng adventitious roots as raw materials, taking the ginseng adventitious roots out of a liquid culture medium, cleaning and removing the residual liquid culture medium on the surfaces of the ginseng adventitious roots, and removing moisture on the surfaces of the ginseng adventitious roots; and (b) suspending the ginseng adventitious roots obtained in the step (a) in high-temperature and high-pressure equipment, adding water into the bottom of the high-temperature and high-pressure equipment, heating to generate high-temperature and high-pressure steam to carry out high-temperature and high-pressure conversion on the ginseng adventitious roots, and controlling reaction parameters to obtain finished ginseng adventitious roots with the rare ginsenoside content obviously improved.

The invention provides an anti-hair loss and anti-dandruff composition and a preparation method thereof, and belongs to the technical field of wash supplies. The anti-hair loss and anti-dandruff composition is prepared from the following raw materials: a plant raw material, a plant extract, a caffeine composition and an oil control composition, wherein the plant raw materials comprise the following raw materials in parts by mass: 5-20 parts of ginger root, 5-20 parts of black ginger root, 5-20 parts of alpinia japonica root, 1-3 parts of ligusticum wallichii, 5-10 parts of radix sophorae flavescentis, 2-4 parts of fructus cnidii, 1-5 parts of fructus viticis, 3-5 parts of saponin, 5-8 parts of soapberry peel, 1-5 parts of dandelion, 5-8 parts of polygonum multiflorum, 1-3 parts of mulberry, 3-6 parts of cacumen biotae, 3-6 parts of mulberry leaf, 7-10 parts of purslane and 1-4 parts of mangnolia officinalis; the plant extract is prepared from the following raw materials in parts by mass: 5 to 20 parts of aloe extract, 1 to 10 parts of herba menthae extract, 5 to 20 parts of fructus forsythiae fruit extract, 5 to 20 parts of tea leaf extract, 5 to 20 parts of herba centellae extract and 1 to 10 parts of cordyceps militaris extract. The composition prepared by the invention not only has good anti-dropping and anti-dandruff effects, but also has good stability.

Disclosed are novel pharmaceutical, animal feed compositions and methods of treating non-human animals comprising at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s), or mixtures thereof, derived from non-woody plants of the genus Hesperaloe. Animal feed compositions may comprise a basal animal feed and water soluble solids extracted from Hesperaloe and comprising at least one saponin. The water soluble solids may comprise from about 5 to about 30 wt % saponin. The compositions of the present invention can be used for the treatment of non-human animals, such as poultry and more particularly for preventing and treating coccidiosis. An embodiment provides an immunological composition useful for inducing the production of antibodies to an antigen in a non-human animal comprising an antigen, preferably a coccidia, and a saponin composition extracted from Hesperaloe. The saponins extracted from Hesperaloe biomass may comprise 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside C, furcreastatin and yuccaloiside C.

The invention discloses a preparation method and application of a QS-21-polyamino acid nano vaccine, and belongs to the field of biomedical nano materials. The preparation method comprises the following steps: modifying gamma-PGA with phenylalanine ethyl ester (F) to obtain a polymer PF40 of which the F grafting rate is 40%; aiming at the characteristic that QS-21 is strongly combined with cholesterol, PF40 (PFC) grafted with cholesterol (C) is developed, and PFC wraps OVA and QS-21 through hydrophobic force to construct a nano vaccine OQPFC. The cholesterol on the PFC can reduce the combination of the QS-21 and the cholesterol on a cell membrane so as to reduce the biotoxicity of the QS-21, and the QS-21 loading efficiency of the nano vaccine is improved, so that a better treatment effect is achieved. The OQPFC can escape from lysosome through carboxyl protonation, and a large amount of QS-21 and OVA are released in cytoplasm, so that the synergistic cellular immune activation effect of the carrier adjuvant PFC and the saponin adjuvant QS-21 is realized.

The invention belongs to the technical field of medicines, and particularly relates to a secondary ginsenoside composition and application thereof in prevention and treatment of pulmonary fibrosis and acute lung injury. The secondary ginsenoside composition is prepared from any two or more components selected from the following components: (20S)-Rg2, (20S)-Rh1, (20R)-Rg2, (20R)-Rh1, Rg6, F4, Rk3 and Rh4; (20S)-Rg3, (20R)-Rg3, Rk1, Rg5, (20S)-Rh2, (20R)-Rh2, Rk2 and Rh3 are selected from the group consisting of (20S)-Rg3, (20R)-Rg3, Rk1 and Rg5. The medicine effect of the secondary ginsenoside composition provided by the invention on the aspects of preventing and treating pulmonary fibrosis and acute lung injury is obviously superior to that of a primary ginsenoside composition and secondary saponin Rg5 and Rg3 monomer components. Meanwhile, the secondary ginsenoside composition is more easily absorbed by intestinal tracts than a primary ginsenoside composition, and is slightly influenced by individual differences of intestinal flora. Compared with a secondary saponin monomer component, the compound is easier to prepare, lower in production cost and safer and more efficient compared with existing commercially available drugs.

The invention discloses radix ophiopogonis powder for relieving anxiety and improving sleep. The radix ophiopogonis powder is prepared by carrying out fermentation on radix ophiopogonis through plant lactobacillus GDMCC No. 64374 and carrying out enzymolysis treatment through pullulanase. The invention further discloses a preparation method and application of the radix ophiopogonis powder. The saponin content of the radix ophiopogonis powder is obviously increased. The radix ophiopogonis powder can be prepared into products in various forms, has the effects of relieving anxiety mood and improving sleep, is high in bioavailability and free of toxic and side effects, and can be eaten for a long time. Compared with the traditional radix ophiopogonis powder, the radix ophiopogonis powder disclosed by the invention is relatively low in safety risk and more obvious in effects of relieving anxiety mood and improving sleep.

The invention discloses an application of aescin in preparation of a fruit fly insect antifeedant. The invention proposes that the natural plant medicine aescin can be used as the insect antifeedant for the first time, and verification shows that the aescin has a remarkable antifeedant effect on adult and larva of bactrocera dorsalis, can be used as the antifeedant for the fruit fly pests, is further developed into a natural medicine for preventing and controlling the fruit fly pests, and has a wide application prospect. The composition is nontoxic and nuisanceless to various crops, vegetables, melons and fruits and other commercial crops, does not generate drug resistance of chemical drugs, does not pollute the environment or harm human health, and has a very good application prospect.

The invention belongs to the technical field of emulsion preparation, and particularly relates to cinnamon essential oil emulsion as well as a preparation method and application thereof. The cassia bark essential oil emulsion is prepared by jointly emulsifying cassia bark essential oil by utilizing a Chinese honeylocust fruit water extract and soybean protein isolate. The production process is simple, the production cost is low, large-scale production is facilitated, and the prepared cinnamon essential oil emulsion has good storage stability at the temperature of 4 DEG C and also shows excellent electrolyte, pH value, temperature and freeze-thaw stability. The method is suitable for the fields of food, packaging materials, medicines and the like, and the preservation capacity of the prepared cinnamon essential oil emulsion can be comparable with that of a commercial food preservative potassium sorbate.

The invention discloses a high-utilization-rate ginseng active ingredient medicinal preparation and a preparation method thereof, and relates to the technical field of medicines. The high-utilization-rate ginseng active ingredient pharmaceutical preparation is prepared from chitosan coated drug-loaded porous silicon dioxide composite nanoparticles and a drug-loaded MIL-101 metal organic framework matrix material, chitosan-coated drug-loading porous silicon dioxide composite nanoparticles are loaded on the surface of a drug-loading MIL-101 metal organic framework base material, and sodium alginate and a chitosan gel material are subjected to cross-linking connection, so that independent coating is formed, the framework base material and the composite nanoparticles are connected into a whole, the encapsulation performance and the drug loading capacity are improved, and the drug-loading capacity of the drug-loading MIL-101 metal organic framework composite nanoparticles is improved. Furthermore, the loading and the loading stability of the ginsenoside are improved, the adverse effects of gastric juice and gastrointestinal peristalsis on the activity of the ginsenoside are effectively reduced, the release and the absorption of the ginsenoside in intestinal tracts are remarkably enhanced, and the bioavailability is relatively high.

The invention discloses application of a plant extract in preparation of a drug for resisting canine coronavirus, and relates to the technical field of biological medicine. Research finds that plant extracts-shikimic acid, phloretin, caffeic acid, tribulus terrestris saponin, berberine hydrochloride and apple polyphenol have activity of resisting canine coronavirus, wherein the effect of phloretin is most remarkable. The phloretin has antiviral activity in three aspects of direct killing, inhibition of virus adsorption and inhibition of virus growth, wherein the effect of inhibiting virus growth is most significant. And the EC50 of the phloretin acting on the CCoV is 0.616 mg / L. The plant extract provided by the invention is derived from natural plants, and has the advantages of low toxicity and good biocompatibility compared with chemical drugs. The invention provides a technical support for developing a novel, effective, safe and side-effect-free medicinal preparation for preventing and treating canine coronavirus.