537 results about "Composite nanoparticles" patented technology

The invention relates to the technical field of phase change heat storage, in particular to a test method of a composite nanoparticle latent heat system based on a Fibonacci fractal tree-shaped fin. The test method comprises the following steps: firstly, establishing a physical model of a nanoparticle three-sleeve vertical latent heat system based on the Fibonacci fractal tree-shaped fin; secondly, performing two-dimensional simulation analysis on the physical model by adopting a two-dimensional model, simulating the melting and solidification process of the PCM, analyzing the heat transfer performance and energy storage efficiency of the system, building an experimental device of a nano-particle three-sleeve vertical latent heat system based on the Fibonacci fractal tree-shaped fins, selecting proper PCM and nano-particles, simulating different working conditions, and establishing a three-sleeve vertical latent heat system based on the nano-particle three-sleeve vertical latent heat system based on the Fibonacci fractal tree-shaped fins. And finally, comparing a simulation result with an experimental result, adjusting parameters of a simulation model, improving the accuracy of the simulation result, analyzing the influence of different fin bifurcation angles, nanoparticle types, wall surface temperatures and fin materials on the heat transfer performance and energy storage efficiency of the system, and providing guidance for optimal design of the system.

A graphene composite nanoparticle abrasive flexible fluid electric field-ultrasonic auxiliary polishing method comprises the following steps that S1, primary chemical bonding and graft copolymerization of graphene and nanoparticles are achieved through a dynamic high shear field-ultrasonic synergistic induction method; and then compounding the primary abrasive material and the secondary graphene into the graphene composite nano-particle abrasive material of a multi-layer structured coating system with a core-shell structure through a dynamic high shear field-ultrasonic synergistic induction method. S2, arranging and moving of the particles on the surface are adjusted by applying an electric field; s3, ultrasonic waves are applied in the polishing process, contact between particles and the surface is improved, and surface defects are removed; and S4, the micro state of the abrasive particles and the surface state of the workpiece in the polishing process are tracked. The invention further provides a device for implementing the method. The polishing precision, the surface smoothness, the polishing speed and the polishing uniformity are improved, and the energy consumption is reduced; the polishing consistency and stability are improved, the machining cost is reduced, and the rejection rate is reduced.

The invention discloses novel vegetable protein-polysaccharide composite nanoparticle stable powdered oil and a preparation method thereof, and belongs to the technical field of powdered oil preparation. The preparation method of the novel vegetable protein-polysaccharide powdered oil comprises the following steps: adding water into vegetable protein, dispersing, stirring overnight, and hydrating to obtain vegetable protein dispersion liquid; adding water to disperse polysaccharide, stirring overnight and hydrating to obtain a polysaccharide dispersion liquid; mixing the vegetable protein dispersion liquid with the polysaccharide dispersion liquid, adjusting the pH value to be alkaline, heating, stirring, cooling, and adjusting the pH value to be neutral, so as to obtain vegetable protein-polysaccharide composite nanoparticle dispersion liquid; and adding an oil phase, shearing and emulsifying, homogenizing at high pressure, and finally spray-drying. According to the method, the vegetable protein-polysaccharide composite nanoparticles are prepared through the pH shift vegetable protein-polysaccharide mixture, the grease is encapsulated through spray drying, the stability of the grease is improved, the method can also be used for embedding curcumin and other active substances, and a new thought is provided for improving the stability of the active substances.

The invention discloses a flexible PI heat-conducting insulating film pad and a preparation method thereof, and relates to the field of film pads. The preparation method comprises the following steps: preparing Fe3O4 magnetic heat-conducting core and SiO2 insulating shell composite nanoparticles by a sol-gel method, treating and grafting epoxy groups by a silane coupling agent, performing ring-opening addition with one end amino group of amino-terminated polydimethylsiloxane, and reacting the other end amino group with polyethylene glycol diglycidyl ether, so that two flexible long chains are grafted on SiO2. Due to the modified composite nanoparticles and the flexible long-chain structure, the flexibility of the film pad is remarkably improved; thermal vibration of silicon-oxygen bonds and ether bonds promotes heat transfer, a hydrogen bond network is formed with a PI substrate to improve dispersion stability, particles are orderly arranged under the action of a high-frequency magnetic field to construct a three-dimensional heat conduction network, and heat conduction efficiency is enhanced; the SiO2 isolates the inner core from conducting and improves the insulating property of the film pad by virtue of good insulativity and no free charge in the flexible long-chain polymer. The flexible PI heat-conducting insulating film pad prepared by the invention has the effects of flexibility, heat conduction and insulation.

The invention discloses oligochitosan oligosaccharide, oligochitosan oligosaccharide composite nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of nano materials and food engineering. According to the method disclosed by the invention, the chitosan oligosaccharide with the polymerization degree of 2-6 is prepared by adopting an ultrasonic-microwave synergistic compound enzyme enzymolysis method, so that the yield and the quality of the chitosan oligosaccharide are improved. The chitosan oligosaccharide and zein are assembled to form the chitosan oligosaccharide composite nanoparticles, the chitosan oligosaccharide composite nanoparticles have the advantages of being small in particle size and high in stability, the antioxidant function of the chitosan oligosaccharide is remarkably improved, the preparation method is simple, convenient, economical and practical, and the chitosan oligosaccharide composite nanoparticles can be used as food, health care products and medicine carrier materials and have good market application prospects.

The invention relates to the technical field of food processing, and discloses casein-tea polysaccharide-polyphenol composite nanoparticles and a preparation method of the casein-tea polysaccharide-polyphenol composite nanoparticles, and the preparation method comprises the following steps: mixing large yellow tea polysaccharide with a casein solution to obtain a CS / TPS mixed solution; performing glycosylation modification on casein in the CS / TPS mixed solution by adopting a Maillard reaction to prepare a casein-polysaccharide copolymer solution; the preparation method comprises the following steps: mixing a plurality of catechins, dissolving the catechins in ultrapure water to obtain a mixture stock solution, mixing the mixture stock solution and a casein-polysaccharide copolymer solution according to a volume ratio of 1: 16, stirring for 1 hour for self-assembly, pre-freezing the stirred solution at-80 DEG C, and freeze-drying for 48 hours to obtain CS-TPS-MIX nano-composite powder. According to the invention, a polyphenol delivery system with a dual antioxidant synergistic mechanism is constructed through a Maillard reaction mediated nano-composite technology, and the system is stable in structure, so that the release of polyphenol is more controllable.

The invention discloses a composite lithium supplement agent and a preparation method and application thereof, and belongs to the technical field of lithium ion batteries. The composite lithium supplement agent comprises a porous carbon material and lithium oxalate and lithium carbonate nanoparticles which grow on the surface of porous carbon and in a pore structure in situ. According to the composite lithium supplementing agent provided by the invention, lithium oxalate and lithium carbonate composite nanoparticles uniformly distributed in the porous carbon pore structure are obtained by limiting the growth of lithium oxalate and lithium carbonate through the porous carbon pore structure, so that the decomposition voltage of the composite lithium supplementing agent is greatly reduced, and the total lithium supplementing capacity and the continuous lithium supplementing capacity are improved.

The invention discloses a preparation method and application of composite nanoparticles with a gold-silver core-shell structure, and aims to solve the problems that silver halide precipitates are generated on the surface of a silver core and the silver core is etched in the prior art. The thiourea solution is used for replacing a halogen-containing reagent, uniform epitaxial growth of gold on the surface of the silver core is mildly achieved, the gold-shell silver-core nanoparticles which are evenly wrapped and stable in structure are prepared, and the gold-shell silver-core nanoparticles are suitable for the fields of immunodetection and the like and are good in color development effect and low in cost. The method comprises the steps of preparing a gold salt solution, preparing gold nano-seeds, preparing silver nano-cores and generating gold-shell silver-core nano-particles through a chemical reduction reaction, and the problem that a core-shell structure grows unevenly is solved. When the method is applied to immunodetection, the material cost can be remarkably reduced, and a better color development effect can be achieved.

The invention relates to the technical field of abdominal wall adhesion materials induced by prevention and treatment of bacterial infection, and discloses an ionic liquid-based antibacterial-anti-inflammatory integrated bioactive nanoparticle with microwave sensitivity, a preparation method and application of the ionic liquid-based antibacterial-anti-inflammatory integrated bioactive nanoparticle. Then, the surfaces of the hollow nano particles are modified with bacteria specific targeting molecule 3-aminophenylboronic acid, and PBA-HPDA is formed; finally, chlorogenic acid and quaternary ammonium salt are combined according to a certain proportion to form ionic liquid (ILs) with a microwave heat effect, the ionic liquid (ILs) is wrapped in HPDA, and composite nanoparticles PBA-HPDA-CAQAC are formed. The nano particle material prepared by the invention has microwave heat effect and antibacterial and anti-inflammatory integrated biological activity, and has excellent bactericidal and anti-inflammatory effects.

The invention discloses an RGD-click chemical crosslinking siRNA nano-carrier, a preparation method thereof and application of the nano-carrier in preparation of a medicine for treating secondary thyroidism, and belongs to the technical field of medicines.The nano-carrier is RGD-PEG-PLys (N), and the preparation method of the nano-carrier comprises the steps of synthesis of PLys (ss-DBCO), synthesis of RGD-PEG-PLys (N) and the like. According to the application, the nano-carrier is used for preparing siRNA composite nanoparticles; vascular endothelial targeting (RGD), dynamic stability (click crosslinking) and microenvironment responsiveness (disulfide bond) are organically combined for the first time to achieve mutual synergistic interaction, and the effect ceiling of an existing material is broken through; according to the siRNA composite nanoparticle, the silence effect of the PTH gene as long as 70 days can be achieved through single intravenous injection, the PTH inhibition rate is larger than 85%, the siRNA accumulation amount in parathyroid gland tissue is remarkably increased through RGD targeting (8.6 times that of a non-targeting group), the liver and kidney distribution amount is reduced by 60%, and the system toxicity is controllable.

The invention relates to the technical field of hydrogel microneedle preparation, in particular to a collagen microneedle patch loaded with copper-based antibacterial nanoparticles and a preparation method and application of the collagen microneedle patch loaded with the copper-based antibacterial nanoparticles. The microneedle patch is prepared from the copper-based antibacterial nanoparticles, recombinant XVII type collagen and sodium alginate; wherein the copper-based antibacterial nano particles are Cu-CpG (at) PDA composite nano particles; the recombinant XVII type collagen protein is rCol XVII; the preparation method of the microneedle patch comprises the following steps: firstly, preparing Cu-CpG (at) PDA nanoparticles from antibacterial copper ions, a nucleic acid immunologic adjuvant CpG oligonucleotide and polydopamine (PDA); then, the Cu-CpG (at) PDA nano-particles are doped into recombinant XVII type collagen (rCol XVII) and sodium alginate, and collagen hydrogel loaded with the Cu-CpG (at) PDA nano-particles is prepared; finally, the hydrogel is laid in a mold, and the collagen microneedle patch loaded with the copper-based antibacterial nanoparticles is prepared after vacuum treatment, centrifugation and drying. The collagen microneedle patch disclosed by the invention has good photo-thermal conversion capacity, antibacterial property and skin regeneration capacity, and can be used for treating bacterial infection and promoting wound closure.

The invention provides a dry powder drag reducer for fracturing fluid and a preparation method of the dry powder drag reducer, and belongs to the technical field of fracturing materials for well drilling, and the preparation method comprises the following steps: dissolving 4-bromobutyryl chloride and N-dodecyl methylamine in acetonitrile, heating and stirring for reaction, adding polyethylene glycol monomethyl ether acrylate and dichloromethane, stirring and purifying in a nitrogen atmosphere to obtain a dry powder drag reducer; a double-tailed hydrophobic monomer is obtained; uniformly mixing the core-shell SiO2 / Fe3O4 composite nanoparticles, an ethanol water solution, KH570 and an ammonia solution, stirring, and purifying to obtain modified SiO2 / Fe3O4; the preparation method comprises the following steps: adding acrylamide, acrylic acid, sodium 2-acrylamido-2-methylpropanesulfonate, a double-tailed hydrophobic monomer and modified SiO2 / Fe3O4 into water, uniformly mixing, adjusting the pH value, introducing nitrogen, mixing and stirring, adding an azo initiator, stirring, cooling, purifying, carrying out vacuum drying, and crushing into powder, thereby obtaining the dry powder drag reducer for the fracturing fluid. The drag reducer has certain heat resistance while achieving good drag reduction performance, and can be better applied to fracturing operation in the well drilling process.

The invention discloses a high-utilization-rate ginseng active ingredient medicinal preparation and a preparation method thereof, and relates to the technical field of medicines. The high-utilization-rate ginseng active ingredient pharmaceutical preparation is prepared from chitosan coated drug-loaded porous silicon dioxide composite nanoparticles and a drug-loaded MIL-101 metal organic framework matrix material, chitosan-coated drug-loading porous silicon dioxide composite nanoparticles are loaded on the surface of a drug-loading MIL-101 metal organic framework base material, and sodium alginate and a chitosan gel material are subjected to cross-linking connection, so that independent coating is formed, the framework base material and the composite nanoparticles are connected into a whole, the encapsulation performance and the drug loading capacity are improved, and the drug-loading capacity of the drug-loading MIL-101 metal organic framework composite nanoparticles is improved. Furthermore, the loading and the loading stability of the ginsenoside are improved, the adverse effects of gastric juice and gastrointestinal peristalsis on the activity of the ginsenoside are effectively reduced, the release and the absorption of the ginsenoside in intestinal tracts are remarkably enhanced, and the bioavailability is relatively high.

The invention discloses a polyphenol-mediated high-internal-phase Pickering emulsion as well as a preparation method and application thereof, and belongs to the crossing field of food science and biological medicine application. The preparation method of the high-internal-phase Pickering emulsion comprises the following steps: respectively dissolving polyphenol, food-grade aldehydes, proteins, peptides or amino acids in water, then mixing the three solutions, and carrying out magnetic stirring under a normal-temperature dark condition to obtain a mixed system; then centrifuging, and freeze-drying the precipitate to obtain polyphenol composite nanoparticles; and dissolving the polyphenol composite nanoparticles in water to obtain a nanoparticle suspension, mixing the nanoparticle suspension with vegetable oil, and performing high-speed dispersion to obtain the polyphenol-mediated high-internal-phase Pickering emulsion. The polyphenol-mediated high-internal-phase Pickering emulsion has good biocompatibility, is stable in digestion of gastrointestinal tracts, and has a very excellent application prospect in the industries of medicines and health care products.

The invention discloses a preparation method of a curcumin-loaded Pickering emulsion steady-state carrier and tea protein-chitosan composite nanoparticles used by the curcumin-loaded Pickering emulsion steady-state carrier, and belongs to the technical field of high-valued processing of food functional factors. The preparation method comprises the following steps: firstly, extracting tea protein from a tea leaf processing byproduct tea residue by adopting an alkali extraction and acid precipitation method, and secondly, constructing the tea protein-chitosan composite nanoparticles by adopting a pH induction method. And mixing the oil phase containing curcumin with the water phase, and emulsifying by using a high-speed shearing machine to prepare the Pickering emulsion. The method is simple to operate, the prepared Pickering emulsion stabilized by the tea protein-chitosan composite nanoparticles can improve the bioavailability of curcumin from 10.8% to 32.6%, meanwhile, high-value utilization of the tea protein is achieved, and the method has important significance in promoting development and application of functional food.

The invention discloses an anti-corrosion self-repairing super-amphiphobic coating film and a preparation method thereof, and belongs to the technical field of polymer coating materials. The coating film sequentially comprises a nano particle skeleton layer, a dynamic borate bond layer and a super-amphiphobic functional layer from inside to outside, and the three-layer gradient design synergistically realizes micro / nano structure stability, self-repairing and super-amphiphobic functions. The framework layer takes SiO2-TiO2 composite nanoparticles as a substrate and provides support; the dynamic boric acid ester bond layer forms a dynamic network through polycondensation of an organic boron compound, endows the self-repairing capability and enhances interface bonding; the super-amphiphobic functional layer is formed by grafting a fluorine-containing organosilicon compound and has hydrophobic and oleophobic properties. A multi-layer structure is constructed step by step, the reaction condition is mild, the operation is simple, the cost is low, the method is suitable for large-scale industrial preparation, the coating film has excellent super-amphiphobic performance and interface adhesion performance, the super-amphiphobic performance of the coating film can still be kept stable in long-term use or a complex environment, and the problem that an existing super-amphiphobic material is prone to damage is effectively solved.

The present invention discloses coated hydrophobic polyphenol nanoparticles, preparation method therefor and application thereof. The preparation method for coated hydrophobic polyphenol nanoparticles includes: (1) obtaining a hydrophobic polyphenol nanoparticles suspension; (2) injecting a catechin aqueous solution and a metal salt aqueous solution into the hydrophobic polyphenol nanoparticles suspension to obtain a composite nanoparticles suspension; (3) removing excess catechin and metal ions from the composite nanoparticles suspension to obtain a coated hydrophobic polyphenol nanoparticles suspension. The present invention provides an application of the coated hydrophobic polyphenol nanoparticles in the preparation of pectin gel. The coated hydrophobic polyphenol nanoparticles exhibit significantly enhanced biological activity and long-term stability, developing a pectin gel with long-term stability.

The invention provides a composite nanoparticle with active substance sequential release capability, a multifunctional microneedle patch based on curcumin-loaded ZIF-67 nanoparticles, preparation methods of the composite nanoparticle and the multifunctional microneedle patch and application of the multifunctional microneedle patch, and belongs to the technical field of biology. The composite nano-particles with the active substance sequential release capability are CurZIF-67NPs, the average particle size is 403 + / -7 nm, the microstructure is dodecahedral structure particles with rough textures on the surface, and the composite nano-particles have the effects of slowly releasing bioactive substances, improving the inflammatory microenvironment and regulating and controlling osteogenesis under certain conditions. The composite nano-particle comprises curcumin powder and a ZIF-67 nano-material, the ZIF-67 nano-material can be decomposed to quickly release Co < 2 + >, macrophages are regulated and controlled to be polarized to an M2 type, and excessive immune inflammation reaction is improved; the curcumin powder is slowly released, so that the periodontal ligament stem cells can be regulated and controlled to be differentiated into osteoblasts, and the osteogenic activity is enhanced.

The invention discloses a dual-emission molecular imprinting ratiometric fluorescence sensor, a preparation method thereof and application of the dual-emission molecular imprinting ratiometric fluorescence sensor in aureomycin detection, and belongs to the technical field of chemical sensors. The preparation method of the sensor comprises the following steps: preparing silicon dioxide-quantum dot composite nanoparticles, and preparing a molecularly imprinted polymer by taking salicylamide as a template molecule; and mixing the molecularly imprinted polymer and the silicon dioxide-quantum dot composite nanoparticles in an HEPES buffer solution by adopting a post-mixing strategy to construct the dual-emission molecularly imprinted ratiometric fluorescence sensor. The double-emission molecular imprinting ratiometric fluorescence sensor has the beneficial effects that the double-emission molecular imprinting ratiometric fluorescence sensor provided by the invention is rich in fluorescence color change, rapid, high-sensitivity and visual detection of aureomycin can be realized, the whole detection process is simple, convenient and rapid, and the double-emission molecular imprinting ratiometric fluorescence sensor is suitable for being widely popularized in practical application.

The present disclosure relates to a method for easily preparing niobium-containing titanium-ruthenium composite nanoparticles with excellent stability and electrochemical properties, niobium-containing titanium-ruthenium composite nanoparticles with excellent stability and efficiency, and a chlorine evolution electrode comprising the same.

The embodiment of the invention provides a plastic-coated steel pipe and a plastic coating process thereof, and relates to the technical field of plastic-coated steel pipes. The plastic-coated steel pipe comprises a steel pipe base body, a metal transition layer, an inner anticorrosive coating, a fiber reinforced winding layer and an outer protective coating are sequentially arranged on the outer surface of the steel pipe base body from inside to outside, and the metal transition layer is a nickel-chromium-aluminum-yttrium alloy layer and is formed on the surface of the steel pipe base body through a supersonic plasma spraying process. And the inner anticorrosive coating is formed by a mixture of bisphenol F type epoxy resin and novolac epoxy resin, and is doped with silicon nitride and zirconium oxide composite nanoparticles subjected to surface treatment. By arranging a multi-stage composite structure of the metal transition layer, the high-temperature-resistant anti-corrosion coating, the fiber reinforcement layer and the self-repairing outer layer and arranging the detachable heat insulation sheath, the interface bonding strength, heat resistance, mechanical damage resistance and corrosion resistance of the plastic-coated steel pipe are improved; and the service life of the composite material in high-temperature, strong-corrosion and complex construction environments is effectively prolonged.

The invention relates to the field of nano materials, in particular to a chitosan and recombinant collagen composite nano material as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing chitosan with an acid solution to obtain a chitosan acid solution; mixing the recombinant collagen with a buffer solution to obtain a recombinant collagen buffer solution; dropwise adding the chitosan acid solution into the recombinant collagen buffer solution, so that the chitosan particles and the recombinant collagen particles are self-assembled into composite nanoparticles; the particle size of the composite nanoparticles is smaller than or equal to 300 nm. The chitosan acid solution and the recombinant collagen buffer solution form a stable nanoparticle structure through the self-assembly effect of positive and negative charges, and the problem of toxicity introduced by traditional chemical crosslinking is avoided. The particle size of the composite nanoparticles is less than or equal to 300nm, so that the transdermal efficiency of the collagen is improved; due to the structural characteristics of the nanoparticles, the permeability and the local bioavailability of the medicine are remarkably improved.

The invention discloses a composition containing a polypeptide exosome and application of the composition in preparation of a product with skin repair ability, and particularly relates to the technical field of biology, the composition comprises polypeptide-exosome composite nanoparticles, and a polypeptide containing a GRGDS motif and an umbilical cord Wharton's jelly exosome are covalently crosslinked; the lipid double-layer coating layer comprises phosphatidylcholine, cholesterol and PEG-2000, and the molar ratio of the phosphatidylcholine to the cholesterol to the PEG-2000 is 5: 3: 2; the synergist is prepared from 0.1 to 5 percent of epicatechin gallate and 2 to 8 percent of recombinant collagen III oligopeptide. The nano-liposome is prepared through microfluidic self-assembly and a film hydration-ultrasonic intercalation method, and can be loaded on a degradable microneedle patch, so that targeted slow release of a wound part is realized. Through the synergistic effect of targeted delivery, oxidation resistance and collagen regeneration, the skin repair efficiency is remarkably improved, and the healing time is shortened.

The invention discloses a graphene aerogel modified elastic graphite material and a preparation method thereof, and the graphene aerogel modified elastic graphite material comprises the following components by mass: 50-80 parts of crystalline flake graphite; 8 to 15 parts of graphene aerogel; 3 to 8 parts of aminated modified boron-doped carbon nanotubes; 2 to 6 parts of hydroxyapatite-cerium oxide composite nano particles; 1 to 4 parts of a polyimide-montmorillonite nano composite material; 0.5 to 3 parts of titanate coupling agent modified nano silicon dioxide; 1-3 parts of a dispersant; 2-5 parts of a binder; the amination modified boron-doped carbon nanotubes can enhance the electrical conductivity and interface bonding force of the material, the hydroxyapatite-cerium oxide composite nanoparticles improve the high-temperature stability and mechanical toughness of the material, and the polyimide-montmorillonite nanocomposite improves the corrosion resistance and resilience durability of the material. And the titanate coupling agent modified nano silicon dioxide further optimizes the dispersion uniformity of all the components, and the comprehensive performance of the material is remarkably improved.

The invention discloses a muscle-bone regeneration sustained-release preparation for targeting knee joint cartilage and a preparation process thereof, the preparation is composed of a cartilage targeting peptide modified PLGA-hyaluronic acid composite nanoparticle sustained-release carrier, an active regeneration component, a biocompatible matrix and an anti-inflammatory component, nanoparticles are prepared by a multiple emulsion solvent evaporation method, and targeting peptide is modified; the composite concentrated growth factors, stem cells and traditional Chinese medicine extracts have the functions of targeted enrichment, long-acting slow release, anti-inflammation and cartilage regeneration promotion, and can be used for knee joint cartilage defect repair.

The invention discloses a Pt-based composite nanoparticle catalyst as well as a preparation method and application thereof, the catalyst comprises a V5O12 carrier and Pt nanoparticles loaded on the carrier, and the V5O12 is of a multi-stage layered nanoflower structure; the catalyst is obtained by in-situ generation of Pt nanoparticles on a V5O12 carrier. According to the catalyst disclosed by the invention, the superfine Pt nano-particles are loaded on the metal oxide V5O12, so that the activity and the stability of the catalyst are improved; in addition, the preparation method is simple to operate and low in cost, and large-scale production can be realized.

The invention discloses a drug-loaded protein-phospholipid composite nanoparticle as well as a preparation method and application thereof. The drug-loaded protein-phospholipid composite nanoparticle has a core-shell structure, an inner core comprises silk fibroin and a hydrophilic drug, a shell layer comprises a plurality of phospholipid bimolecular layers which are stacked layer by layer, each phospholipid bimolecular layer comprises soya bean lecithin, a hydrophobic drug is embedded in a hydrophobic region in each phospholipid bimolecular layer, and the hydrophobic drug is embedded in a hydrophobic region in each phospholipid bimolecular layer. Silk fibroin and a hydrophilic drug are embedded in the hydrophilic area, and zein and cholesterol are embedded in the phospholipid bilayer. The drug-loaded protein-phospholipid composite nanoparticle can simultaneously embed a hydrophobic drug and a hydrophilic drug, has the advantages of large drug loading capacity, high bioavailability, good stability, good transdermal permeation effect and the like, has wide application prospects in the fields of transdermal drug delivery preparations and skin care products, and is simple in preparation method, mild in reaction condition and suitable for industrial production. The method is suitable for large-scale industrial production and application.

The invention discloses multi-component inulin hydrogel as well as a preparation method and application thereof, and belongs to the technical field of nano materials and medicines.The multi-component inulin hydrogel is characterized in that a medicine L-alanyl-L-glutamine contributing to intestinal mucosa repair is entrapped in the inulin hydrogel; the multi-component inulin hydrogel has the advantages that the multi-component inulin hydrogel is prepared from the inulin and composite nanoparticles (namely mesoporous polydopamine-gallium composite nanoparticles) composed of an active oxygen scavenger polydopamine and an antibacterial agent gallium ions, the repairing capacity on intestinal barriers is further enhanced, and the prepared multi-component inulin hydrogel can be used for effectively treating inflammatory bowel diseases and non-alcoholic steatohepatitis.

The invention provides an inorganic fiber prepared from industrial solid waste and a preparation method thereof, and belongs to the technical field of inorganic fiber preparation. According to the rare earth doped low-temperature co-melt, a silicon-oxygen network is destroyed and stabilized, the viscosity of solid waste melt is reduced, phase splitting is inhibited, and a uniform melt environment is created; the viscosity of the carbon-coated composite nanoparticles is reduced through in-situ carbon thermal reduction reaction in a synergistic manner, and meanwhile, a reactant gas is utilized to clarify a melt, so that internal defects are removed; the apatite surface modified core-shell nanocrystal is used as a microstructure construction core, a fine and uniform microcrystalline phase is formed in the fiber through induction, and a high-strength basis of the material is constructed; homogenization of the low-temperature co-melt is the premise of subsequent uniform dispersion of additives, core-shell nanocrystals construct a high-strength microcrystalline matrix, carbon-coated particle cores are positioned at a phase interface, the fibers are endowed with high toughness through a physical mechanism, and comprehensive mechanical properties are improved through cooperation of the core-shell nanocrystals, the carbon-coated particle cores and the core-shell nanocrystals.

The invention discloses a zero-blood-permeation Pickering emulsion entrapment system and application thereof.The zero-blood-permeation Pickering emulsion entrapment system is prepared by the steps that spirulina protein isolate and chitosan are dissolved in deionized water respectively, and a spirulina protein isolate solution and a chitosan solution are prepared; the preparation method comprises the following steps: mixing and stirring a spirulina protein isolate solution and a chitosan solution to prepare a spirulina protein isolate-chitosan composite nanoparticle dispersion liquid; and adding an oil phase containing an active matter into the spirulina isolated protein-chitosan composite nanoparticle dispersion liquid, and homogenizing to prepare the stable Pickering emulsion of the spirulina isolated protein-chitosan composite nanoparticles. The penetration enhancing system is used for skin drug delivery, can accurately deliver the drug into the epidermis or corium layer, does not cross the skin barrier to enter blood circulation, and is an optimal drug delivery system for treating diseases in the skin or modifying the skin structure.