367 results about "Composite nanoparticles" patented technology

The invention discloses an RGD-click chemical crosslinking siRNA nano-carrier, a preparation method thereof and application of the nano-carrier in preparation of a medicine for treating secondary thyroidism, and belongs to the technical field of medicines.The nano-carrier is RGD-PEG-PLys (N), and the preparation method of the nano-carrier comprises the steps of synthesis of PLys (ss-DBCO), synthesis of RGD-PEG-PLys (N) and the like. According to the application, the nano-carrier is used for preparing siRNA composite nanoparticles; vascular endothelial targeting (RGD), dynamic stability (click crosslinking) and microenvironment responsiveness (disulfide bond) are organically combined for the first time to achieve mutual synergistic interaction, and the effect ceiling of an existing material is broken through; according to the siRNA composite nanoparticle, the silence effect of the PTH gene as long as 70 days can be achieved through single intravenous injection, the PTH inhibition rate is larger than 85%, the siRNA accumulation amount in parathyroid gland tissue is remarkably increased through RGD targeting (8.6 times that of a non-targeting group), the liver and kidney distribution amount is reduced by 60%, and the system toxicity is controllable.

The invention provides a dry powder drag reducer for fracturing fluid and a preparation method of the dry powder drag reducer, and belongs to the technical field of fracturing materials for well drilling, and the preparation method comprises the following steps: dissolving 4-bromobutyryl chloride and N-dodecyl methylamine in acetonitrile, heating and stirring for reaction, adding polyethylene glycol monomethyl ether acrylate and dichloromethane, stirring and purifying in a nitrogen atmosphere to obtain a dry powder drag reducer; a double-tailed hydrophobic monomer is obtained; uniformly mixing the core-shell SiO2 / Fe3O4 composite nanoparticles, an ethanol water solution, KH570 and an ammonia solution, stirring, and purifying to obtain modified SiO2 / Fe3O4; the preparation method comprises the following steps: adding acrylamide, acrylic acid, sodium 2-acrylamido-2-methylpropanesulfonate, a double-tailed hydrophobic monomer and modified SiO2 / Fe3O4 into water, uniformly mixing, adjusting the pH value, introducing nitrogen, mixing and stirring, adding an azo initiator, stirring, cooling, purifying, carrying out vacuum drying, and crushing into powder, thereby obtaining the dry powder drag reducer for the fracturing fluid. The drag reducer has certain heat resistance while achieving good drag reduction performance, and can be better applied to fracturing operation in the well drilling process.

The invention discloses a preparation method of a curcumin-loaded Pickering emulsion steady-state carrier and tea protein-chitosan composite nanoparticles used by the curcumin-loaded Pickering emulsion steady-state carrier, and belongs to the technical field of high-valued processing of food functional factors. The preparation method comprises the following steps: firstly, extracting tea protein from a tea leaf processing byproduct tea residue by adopting an alkali extraction and acid precipitation method, and secondly, constructing the tea protein-chitosan composite nanoparticles by adopting a pH induction method. And mixing the oil phase containing curcumin with the water phase, and emulsifying by using a high-speed shearing machine to prepare the Pickering emulsion. The method is simple to operate, the prepared Pickering emulsion stabilized by the tea protein-chitosan composite nanoparticles can improve the bioavailability of curcumin from 10.8% to 32.6%, meanwhile, high-value utilization of the tea protein is achieved, and the method has important significance in promoting development and application of functional food.

The invention discloses an anti-corrosion self-repairing super-amphiphobic coating film and a preparation method thereof, and belongs to the technical field of polymer coating materials. The coating film sequentially comprises a nano particle skeleton layer, a dynamic borate bond layer and a super-amphiphobic functional layer from inside to outside, and the three-layer gradient design synergistically realizes micro / nano structure stability, self-repairing and super-amphiphobic functions. The framework layer takes SiO2-TiO2 composite nanoparticles as a substrate and provides support; the dynamic boric acid ester bond layer forms a dynamic network through polycondensation of an organic boron compound, endows the self-repairing capability and enhances interface bonding; the super-amphiphobic functional layer is formed by grafting a fluorine-containing organosilicon compound and has hydrophobic and oleophobic properties. A multi-layer structure is constructed step by step, the reaction condition is mild, the operation is simple, the cost is low, the method is suitable for large-scale industrial preparation, the coating film has excellent super-amphiphobic performance and interface adhesion performance, the super-amphiphobic performance of the coating film can still be kept stable in long-term use or a complex environment, and the problem that an existing super-amphiphobic material is prone to damage is effectively solved.

The present invention discloses coated hydrophobic polyphenol nanoparticles, preparation method therefor and application thereof. The preparation method for coated hydrophobic polyphenol nanoparticles includes: (1) obtaining a hydrophobic polyphenol nanoparticles suspension; (2) injecting a catechin aqueous solution and a metal salt aqueous solution into the hydrophobic polyphenol nanoparticles suspension to obtain a composite nanoparticles suspension; (3) removing excess catechin and metal ions from the composite nanoparticles suspension to obtain a coated hydrophobic polyphenol nanoparticles suspension. The present invention provides an application of the coated hydrophobic polyphenol nanoparticles in the preparation of pectin gel. The coated hydrophobic polyphenol nanoparticles exhibit significantly enhanced biological activity and long-term stability, developing a pectin gel with long-term stability.

The invention discloses a dual-emission molecular imprinting ratiometric fluorescence sensor, a preparation method thereof and application of the dual-emission molecular imprinting ratiometric fluorescence sensor in aureomycin detection, and belongs to the technical field of chemical sensors. The preparation method of the sensor comprises the following steps: preparing silicon dioxide-quantum dot composite nanoparticles, and preparing a molecularly imprinted polymer by taking salicylamide as a template molecule; and mixing the molecularly imprinted polymer and the silicon dioxide-quantum dot composite nanoparticles in an HEPES buffer solution by adopting a post-mixing strategy to construct the dual-emission molecularly imprinted ratiometric fluorescence sensor. The double-emission molecular imprinting ratiometric fluorescence sensor has the beneficial effects that the double-emission molecular imprinting ratiometric fluorescence sensor provided by the invention is rich in fluorescence color change, rapid, high-sensitivity and visual detection of aureomycin can be realized, the whole detection process is simple, convenient and rapid, and the double-emission molecular imprinting ratiometric fluorescence sensor is suitable for being widely popularized in practical application.

The embodiment of the invention provides a plastic-coated steel pipe and a plastic coating process thereof, and relates to the technical field of plastic-coated steel pipes. The plastic-coated steel pipe comprises a steel pipe base body, a metal transition layer, an inner anticorrosive coating, a fiber reinforced winding layer and an outer protective coating are sequentially arranged on the outer surface of the steel pipe base body from inside to outside, and the metal transition layer is a nickel-chromium-aluminum-yttrium alloy layer and is formed on the surface of the steel pipe base body through a supersonic plasma spraying process. And the inner anticorrosive coating is formed by a mixture of bisphenol F type epoxy resin and novolac epoxy resin, and is doped with silicon nitride and zirconium oxide composite nanoparticles subjected to surface treatment. By arranging a multi-stage composite structure of the metal transition layer, the high-temperature-resistant anti-corrosion coating, the fiber reinforcement layer and the self-repairing outer layer and arranging the detachable heat insulation sheath, the interface bonding strength, heat resistance, mechanical damage resistance and corrosion resistance of the plastic-coated steel pipe are improved; and the service life of the composite material in high-temperature, strong-corrosion and complex construction environments is effectively prolonged.

The invention discloses a graphene aerogel modified elastic graphite material and a preparation method thereof, and the graphene aerogel modified elastic graphite material comprises the following components by mass: 50-80 parts of crystalline flake graphite; 8 to 15 parts of graphene aerogel; 3 to 8 parts of aminated modified boron-doped carbon nanotubes; 2 to 6 parts of hydroxyapatite-cerium oxide composite nano particles; 1 to 4 parts of a polyimide-montmorillonite nano composite material; 0.5 to 3 parts of titanate coupling agent modified nano silicon dioxide; 1-3 parts of a dispersant; 2-5 parts of a binder; the amination modified boron-doped carbon nanotubes can enhance the electrical conductivity and interface bonding force of the material, the hydroxyapatite-cerium oxide composite nanoparticles improve the high-temperature stability and mechanical toughness of the material, and the polyimide-montmorillonite nanocomposite improves the corrosion resistance and resilience durability of the material. And the titanate coupling agent modified nano silicon dioxide further optimizes the dispersion uniformity of all the components, and the comprehensive performance of the material is remarkably improved.

The invention discloses a muscle-bone regeneration sustained-release preparation for targeting knee joint cartilage and a preparation process thereof, the preparation is composed of a cartilage targeting peptide modified PLGA-hyaluronic acid composite nanoparticle sustained-release carrier, an active regeneration component, a biocompatible matrix and an anti-inflammatory component, nanoparticles are prepared by a multiple emulsion solvent evaporation method, and targeting peptide is modified; the composite concentrated growth factors, stem cells and traditional Chinese medicine extracts have the functions of targeted enrichment, long-acting slow release, anti-inflammation and cartilage regeneration promotion, and can be used for knee joint cartilage defect repair.

The invention discloses a Pt-based composite nanoparticle catalyst as well as a preparation method and application thereof, the catalyst comprises a V5O12 carrier and Pt nanoparticles loaded on the carrier, and the V5O12 is of a multi-stage layered nanoflower structure; the catalyst is obtained by in-situ generation of Pt nanoparticles on a V5O12 carrier. According to the catalyst disclosed by the invention, the superfine Pt nano-particles are loaded on the metal oxide V5O12, so that the activity and the stability of the catalyst are improved; in addition, the preparation method is simple to operate and low in cost, and large-scale production can be realized.

The invention discloses multi-component inulin hydrogel as well as a preparation method and application thereof, and belongs to the technical field of nano materials and medicines.The multi-component inulin hydrogel is characterized in that a medicine L-alanyl-L-glutamine contributing to intestinal mucosa repair is entrapped in the inulin hydrogel; the multi-component inulin hydrogel has the advantages that the multi-component inulin hydrogel is prepared from the inulin and composite nanoparticles (namely mesoporous polydopamine-gallium composite nanoparticles) composed of an active oxygen scavenger polydopamine and an antibacterial agent gallium ions, the repairing capacity on intestinal barriers is further enhanced, and the prepared multi-component inulin hydrogel can be used for effectively treating inflammatory bowel diseases and non-alcoholic steatohepatitis.

The invention provides an inorganic fiber prepared from industrial solid waste and a preparation method thereof, and belongs to the technical field of inorganic fiber preparation. According to the rare earth doped low-temperature co-melt, a silicon-oxygen network is destroyed and stabilized, the viscosity of solid waste melt is reduced, phase splitting is inhibited, and a uniform melt environment is created; the viscosity of the carbon-coated composite nanoparticles is reduced through in-situ carbon thermal reduction reaction in a synergistic manner, and meanwhile, a reactant gas is utilized to clarify a melt, so that internal defects are removed; the apatite surface modified core-shell nanocrystal is used as a microstructure construction core, a fine and uniform microcrystalline phase is formed in the fiber through induction, and a high-strength basis of the material is constructed; homogenization of the low-temperature co-melt is the premise of subsequent uniform dispersion of additives, core-shell nanocrystals construct a high-strength microcrystalline matrix, carbon-coated particle cores are positioned at a phase interface, the fibers are endowed with high toughness through a physical mechanism, and comprehensive mechanical properties are improved through cooperation of the core-shell nanocrystals, the carbon-coated particle cores and the core-shell nanocrystals.

This invention discloses a protein-polysaccharide ternary nanoparticle loaded with cordycepin, its preparation method, and its applications. The invention employs a layer-by-layer self-assembly method to modify the surface of zein nanoparticles. Since zein has a positive surface charge, the first layer modification uses the anionic polysaccharide sodium alginate for electrostatic bonding, and the second layer modification uses the cationic polysaccharide chitosan, constructing positively charged ternary composite nanoparticles. These nanoparticles have small particle size, high encapsulation efficiency, high drug loading capacity, and a sustained-release effect, significantly reducing cytotoxicity and significantly improving the therapeutic effect on osteoarthritis. This invention develops a novel cordycepin formulation, overcoming the limitations of cordycepin's clinical use.

The invention discloses MnO2 (at) ZIF-67 composite nanoparticles with high oxidase activity as well as a preparation method and application of the MnO2 (at) ZIF-67 composite nanoparticles. The preparation method comprises the following steps: uniformly mixing a potassium permanganate aqueous solution and a cerous nitrate aqueous solution to obtain a mixed solution I; and adding nitric acid into the mixed solution I, carrying out hydrothermal reaction to obtain a substance MnO2, uniformly mixing the obtained MnO2 and a methanol solution of PVP, adding cobalt nitrate hexahydrate and 2-methylimidazole, and standing to obtain the MnO2 ZIF-67 composite nanoparticles. The nano-particles with high enzymatic activity are prepared through a simple hydrothermal synthesis method, have good oxidase mimetic activity, catalyze O2 and TMB to rapidly develop color and become dark blue, and can specifically, sensitively and rapidly detect the total antioxidant capacity of cells, so that the nano-particles have good practical application value.

This invention provides a dry powder drag-reducing agent for fracturing fluids and its preparation method, belonging to the technical field of fracturing materials for drilling. The method includes the following steps: dissolving 4-bromobutyryl chloride and N-dodecylmethylamine in acetonitrile, heating and stirring to react; adding polyethylene glycol monomethyl ether acrylate and dichloromethane; stirring under a nitrogen atmosphere; purifying to obtain a double-tailed hydrophobic monomer; mixing core-shell Fe3O4 / SiO2 composite nanoparticles, ethanol aqueous solution, KH570, and ammonia solution; stirring; purifying to obtain modified SiO2 / Fe3O4; adding acrylamide, acrylic acid, sodium 2-acrylamido-2-methylpropanesulfonate, the double-tailed hydrophobic monomer, and modified SiO2 / Fe3O4 to water; adjusting the pH value; mixing and stirring with nitrogen gas; adding an azo initiator; stirring; cooling; purifying; vacuum drying; and pulverizing into powder to obtain the dry powder drag-reducing agent for fracturing fluids. This invention achieves good drag-reducing performance while also possessing certain heat resistance, making it better suited for fracturing operations in drilling processes.

The invention provides a xanthophyll nano-particle based on electrostatic self-assembly, which is formed by electrostatic self-assembly and spontaneous aggregation of polyglutamic acid and chitosan oligosaccharide and embedding of xanthophyll at the same time. The mass ratio of the polyglutamic acid to the chitosan oligosaccharide to the xanthophyll is 4: 600: 3; the particle size of the xanthophyll nanoparticles is 180-250 nm, and the encapsulation efficiency of the xanthophyll nanoparticles is 60-90%; the preparation process comprises the following steps: mixing a polyglutamic acid aqueous solution and a xanthophyll anhydrous alcohol solution, and fully mixing and stirring for later use; dropwise adding the mixed solution into the chitosan oligosaccharide aqueous solution, and fully stirring and mixing to obtain a xanthophyll nanoparticle solution; and removing insoluble xanthophyll, and freeze-drying to obtain the xanthophyll composite nanoparticles.

The invention discloses nanoparticles for synergistically treating tumors and a preparation method of the nanoparticles, and relates to the technical field of preparation of drugs containing inorganic active ingredients. The nanoparticles are composite nanoparticles Mo-PDA prepared by mixing and reacting inorganic active ingredients of phosphomolybdic acid Mo-POM and dopamine; the preparation method comprises the following steps: taking Mo-POM (phosphomolybdic acid), then loading Mo-PDA-coated GOx nanoparticles with a spherical structure formed by glucose oxidase (GOx), and carrying out mixing reaction by taking Mo-POM, adding deionized water, then adding dopamine, continuously stirring for 1 hour, and continuously reacting for 14-18 hours at the temperature of 150-170 DEG C. According to the preparation method disclosed by the invention, PDA is combined with Mo-containing polyacid salt and externally loaded with glucose oxidase (GOx), so that the PTT-modified CDT-hunger nanoparticle Mo-PDA-GOx for cooperatively treating tumors is synthesized, and the PTT-modified CDT-hunger nanoparticle Mo-PDA-GOx has excellent photo-thermal conversion efficiency which reaches 67.2%. The nanoparticles effectively exert synergistic treatment, and the treatment effect on tumors is improved.

This invention belongs to the field of cosmetic technology, specifically a glycyrrhizin-based composite nanoparticle containing sclerotherapy, BPOXY, and collagen, along with its preparation method and applications. The invention first combines glycyrrhizin and glycyrrhizic acid via non-covalent bonds to obtain a glycyrrhizin-glycyrrhizic acid eutectic structure that overcomes the solubility problem of glycyrrhizin. Then, a BPOXY-collagen mixture is used to coat the glycyrrhizin-glycyrrhizic acid eutectic structure, yielding glycyrrhizin-based composite nanoparticles containing sclerotherapy, BPOXY, and collagen. The glycyrrhizin-based composite nanoparticles containing sclerotherapy, BPOXY, and collagen obtained using this method exhibit good water solubility of glycyrrhizin, a simple composition, high stability, and minimal risk of allergic reactions. Furthermore, it enhances the skin permeability of glycyrrhizin, collagen, and BPOXY, resulting in a synergistic effect and improved bioavailability.

The invention provides a composite sun-screening agent based on an encapsulation technology as well as a preparation method and application of the composite sun-screening agent. The preparation method of the composite sun-screening agent comprises the following steps: fully dispersing hydroxyapatite nanoparticles in an alkaline solvent, adding a dopamine monomer, and carrying out oxidative polymerization reaction, centrifugal washing and drying to obtain HAP-PDA composite nanoparticles; and fully dispersing the HAP-PDA composite nanoparticles in a solvent, adding a mixed solution of a chemical sun-screening agent and an antioxidant and a surfactant, and performing encapsulation reaction and centrifugation to obtain the product. According to the invention, a polydopamine and hydroxyapatite composite encapsulation technology is innovatively adopted, so that the stability and biocompatibility of the sun-screening agent and the antioxidant are remarkably improved, the sun-screening effect is enhanced, and the product is endowed with a lasting sun-screening effect and excellent oxidation resistance. According to the invention, the limitation of a traditional sunscreen product is broken through, and safer, more efficient and more comfortable sunscreen experience can be provided for consumers.

The invention discloses spirulina protein-zein composite nanoparticles and a preparation method and application thereof.The preparation method comprises the steps that a zein solution is added into a spirulina protein solution, ethanol in the solution is removed through evaporation, insoluble substances are removed through centrifugation, and spirulina protein-zein composite nanoparticle dispersion liquid is obtained; and freeze-drying to obtain spirulina protein-zein composite nanoparticle powder. The preparation method of the spirulina protein-zein composite nano-particles is simple, low in cost, green and safe, and the obtained nano-particles can be kept stable in a neutral pH environment, have good biocompatibility, can be applied to efficient embedding of bioactive components, and have good application prospects. The light, heat and storage stability of the bioactive components are remarkably improved; and the oxidation resistance, tyrosinase inhibition and in-vitro release performance of the bioactive components are improved.

The application provides a denitration and CVOCs removal encapsulated bifunctional molecular sieve catalyst and a preparation method and application thereof. y The composite nanoparticle is a core, and the hierarchical porous molecular sieve is a shell layer x -BO y The hierarchical porous-zeolite bifunctional molecular sieve catalyst is prepared by coupling two methods of reverse microemulsion and one-pot two-step dry gel conversion. The catalyst exhibits excellent NO x / CVOCs cooperative catalytic removal activity and stability in a medium-low temperature range (180-520 DEG C), and is suitable for simultaneous purification and removal of NO x and CVOCs in flue gas of waste incineration power generation and hazardous waste incineration pyrolysis industries. The catalyst preparation method is simple, can improve the flue gas pollutant purification efficiency, reduce the industry operation energy consumption and save the production cost.

The invention discloses a drug-loaded polymer, an STAT3 inhibitor composite nanoparticle, a preparation method of the STAT3 inhibitor composite nanoparticle and application of the STAT3 inhibitor composite nanoparticle in ophthalmic drugs. The STAT3 inhibitor composite nanoparticle comprises the drug-loaded polymer, an STAT3 inhibitor loaded on the drug-loaded polymer and thermosensitive lipidosome. The drug-loaded polymer is astaxanthin macromolecules, and the astaxanthin macromolecules are prepared by the following steps: in an inert atmosphere, performing condensation polymerization on astaxanthin and HPMDA, and then performing end capping reaction by using mPEG-OH. The compound is used for treating retinal neuron progressive death and ophthalmic diseases caused by axon loss of the retinal neuron progressive death, can show good ROS response and consumption performance, inhibits necrotic apoptosis, apoptosis and pyroptosis of cells, relieves cell death performance, and can show good drug slow release performance.

The invention relates to the technical field of nano drug loading, in particular to a mixing device and a composite nanoparticle preparation method. In the mixing device, a blocking piece is in an arc shape, the blocking piece is arranged close to the side wall of a fixing base and arranged in the circumferential direction of the fixing base, the blocking piece is provided with a first end and a second end which are opposite, and the distance between the first end and the fixing base is larger than the distance between the second end and the fixing base. The blocking piece can rotate in the circumferential direction of the fixing base, and the first end portion is located in front of the second end portion in the rotating direction of the blocking piece. An installation groove is formed in the side wall of the fixing base and arranged in the radial direction of the fixing base, the visual assembly is installed in the installation groove, and an opening of the installation groove is sealed by a transparent window. The visual assembly is electrically connected with the processor, and the processor is used for determining whether solute particles exist or not according to image data collected by the visual assembly and then judging whether the solute particles are fully dissolved or not. The actual stirring process can be more intuitively and accurately controlled, and the stirring duration can be more reasonably determined.

The invention provides an environment-friendly cable based on a carbon dot composite nano material and a preparation method thereof. The environment-friendly cable comprises a carbon dot modified conductor, and a monofilament is formed by mixing, sintering and drawing copper alloy powder and carbon dot-silver nano composite particles; the carbon dot modified insulating layer is extruded and coated outside the carbon dot modified conductor, and an insulating material comprises a polyolefin matrix, carbon dot-silicon dioxide composite nanoparticles and an antioxidant 1010; the carbon dot modified insulating layer is coated with the carbon dot modified shielding layer, and shielding glue comprises epoxy resin, graphene, carbon dots and a curing agent with the dosage being 8 wt% of the epoxy resin; and the carbon dot modified sheath layer is extruded and coated outside the carbon dot modified shielding layer, and the sheath material comprises an ethylene-vinyl acetate copolymer EVA, a halogen-free intumescent flame retardant, carbon dots and a lubricant. The carbon dot modified environment-friendly cable provided by the invention has halogen-free, low-smoke and flame-retardant characteristics, wide-temperature-range stable operation capability and an on-line state sensing function.

This invention belongs to the field of pharmaceutical technology, specifically relating to a polycyclodextrin / dimethoxyglycine composite nanoparticle, its preparation method, and its application. The composite nanoparticle consists of a polycyclodextrin carrier and a dimethoxyglycine inhibitor. The polycyclodextrin is a poly(isobutylene-maleic anhydride) modified β-cyclodextrin with substituents; the substituents are amino-containing and hydroxyl-containing groups. This composite nanoparticle can effectively improve the stability of DMOGs and achieve polyamine-responsive drug release and polyamine molecule capture. It can achieve dual synergistic effects within the same drug carrier, improving drug bioavailability, reducing toxic side effects, regulating the physicochemical properties of drug molecules, improving the inflammatory microenvironment, and effectively alleviating inflammation by clearing excess polyamines. Simultaneously, the size matching between the cyclodextrin cavity and the polyamine and drug molecules provides favorable conditions for drug delivery and polyamine capture.

The invention provides a nano-composite trace element fertilizer, a preparation method and an application system, the nano-composite trace element fertilizer is a composite trace element fertilizer nano-suspension, and trace element fertilizer composite nanoparticles are suspended in a composite trace element fertilizer clear liquid to form the composite trace element fertilizer nano-suspension; the nanoscale microelement fertilizer has a huge specific surface area, and can greatly improve the absorption and utilization efficiency of microelements; the source of the trace element fertilizer is expanded, not only can trace element salt be used, but also oxides (in a stone state) and simple substance metals (hard blocks) of specific trace elements can be converted into the trace element fertilizer; the slow release time is set according to different application scenes, so that the use convenience is improved; the nanoscale microelement fertilizer can be matched with an organic fertilizer, a compound fertilizer, a water flush fertilizer, an insecticide, a pesticide and the like for use, and can also be applied to a water and fertilizer integrated system; the nanoscale trace element fertilizer has water insolubility, reduces the influence of environmental factors such as raining and the like, and has higher utilization efficiency.

The invention discloses an infectious bone defect bionic repair hydrogel stent and a preparation method and application thereof, and is characterized in that the infectious bone defect bionic repair hydrogel stent is composed of an upper antibacterial-vascularization layer simulating a periosteum structure, a middle support layer simulating a bone cortex structure and a lower regeneration-regulation layer simulating a cancellous bone structure; the upper antibacterial-vascularization layer is prepared from photoresponse CuxO / SiC heterojunction powder, the middle support layer is prepared from silk fibroin, and the lower regeneration-regulation layer is prepared from HAP (at) Cur-CNDs-Pt NPs composite nanoparticles. The multi-dimensional structure and function integration realizes the full-period regulation and control of antibiosis-barrier-regeneration, breaks through the limitation of the traditional single-function stent, and provides an integrated solution for infectious bone defect repair.

This invention provides a method for preparing a daidzein nanoparticle delivery carrier, belonging to the field of food processing technology. Using zein, carrageenan, and sodium alginate as raw materials, this invention utilizes ultrasound technology to construct a novel nanoparticle delivery carrier: zein nanoparticles loaded with a carrageenan / sodium alginate bistabilized layer, thereby improving the stability and bioavailability of daidzein nanoparticles. The advantages of this invention lie in the simplicity and environmental friendliness of the antisolvent precipitation method and ultrasound technology. The prepared composite nanoparticles possess stable physicochemical properties, small particle size, relatively concentrated particle size distribution, and high bioavailability. This invention enhances the practical application value of daidzein-loaded proteoglycan nanoparticles in the food processing industry and provides a theoretical basis for the application of daidzein nanoparticle oral delivery systems.

The application discloses an anti-corrosion self-repairing super-amphiphobic coating film and a preparation method thereof, and belongs to the technical field of high polymer coating materials. The coating film is sequentially composed of a nanoparticle skeleton layer, a dynamic borate ester bond layer and a super-amphiphobic functional layer. The three-layer gradient design cooperatively realizes micro / nano structure stability, self-repairing and super-amphiphobic functions. The skeleton layer takes SiO2-TiO2 composite nanoparticles as a substrate to provide support. The dynamic borate ester bond layer forms a dynamic network through organic boron compound polycondensation, and is endowed with self-repairing capability and enhanced interface combination. The super-amphiphobic functional layer is formed by grafting fluorine-containing organosilicon compounds, and has hydrophobic and oleophobic properties. The multilevel structure is constructed in steps, the reaction condition is mild, the operation is simple, the cost is low, and the method is suitable for large-scale industrial preparation. The coating film has excellent super-amphiphobic performance and interface adhesion performance, and the super-amphiphobic performance of the coating film can still be kept stable in long-term use or complex environment, and the problem that existing super-amphiphobic materials are prone to damage is effectively solved.

The invention discloses a Pickering emulsion with stable starch-myricetin composite nanoparticles and a preparation method of the Pickering emulsion, and belongs to the technical field of starch modification and emulsion delivery. Starch and myricetin are combined and compounded, a dynamic high-pressure microjet homogenization technology is introduced, the starch-myricetin composite nano-particles capable of stabilizing Pickering emulsion are obtained through a one-step method, and the application limitation that nano-starch is high in hydrophilicity, high in digestibility and the like is effectively solved; the prepared starch-myricetin composite nanoparticles have the characteristics of high stability and slow digestion function; the Pickering emulsion is prepared by further matching with a compound oil phase of coconut oil and cinnamon essential oil, so that the problem of coconut oil solidification can be effectively solved, and the Pickering emulsion has an antibacterial effect.