232 results about "Composite nanoparticles" patented technology

The invention discloses a graphene aerogel modified elastic graphite material and a preparation method thereof, and the graphene aerogel modified elastic graphite material comprises the following components by mass: 50-80 parts of crystalline flake graphite; 8 to 15 parts of graphene aerogel; 3 to 8 parts of aminated modified boron-doped carbon nanotubes; 2 to 6 parts of hydroxyapatite-cerium oxide composite nano particles; 1 to 4 parts of a polyimide-montmorillonite nano composite material; 0.5 to 3 parts of titanate coupling agent modified nano silicon dioxide; 1-3 parts of a dispersant; 2-5 parts of a binder; the amination modified boron-doped carbon nanotubes can enhance the electrical conductivity and interface bonding force of the material, the hydroxyapatite-cerium oxide composite nanoparticles improve the high-temperature stability and mechanical toughness of the material, and the polyimide-montmorillonite nanocomposite improves the corrosion resistance and resilience durability of the material. And the titanate coupling agent modified nano silicon dioxide further optimizes the dispersion uniformity of all the components, and the comprehensive performance of the material is remarkably improved.

The invention discloses a Pt-based composite nanoparticle catalyst as well as a preparation method and application thereof, the catalyst comprises a V5O12 carrier and Pt nanoparticles loaded on the carrier, and the V5O12 is of a multi-stage layered nanoflower structure; the catalyst is obtained by in-situ generation of Pt nanoparticles on a V5O12 carrier. According to the catalyst disclosed by the invention, the superfine Pt nano-particles are loaded on the metal oxide V5O12, so that the activity and the stability of the catalyst are improved; in addition, the preparation method is simple to operate and low in cost, and large-scale production can be realized.

This invention discloses a protein-polysaccharide ternary nanoparticle loaded with cordycepin, its preparation method, and its applications. The invention employs a layer-by-layer self-assembly method to modify the surface of zein nanoparticles. Since zein has a positive surface charge, the first layer modification uses the anionic polysaccharide sodium alginate for electrostatic bonding, and the second layer modification uses the cationic polysaccharide chitosan, constructing positively charged ternary composite nanoparticles. These nanoparticles have small particle size, high encapsulation efficiency, high drug loading capacity, and a sustained-release effect, significantly reducing cytotoxicity and significantly improving the therapeutic effect on osteoarthritis. This invention develops a novel cordycepin formulation, overcoming the limitations of cordycepin's clinical use.

The invention provides a composite sun-screening agent based on an encapsulation technology as well as a preparation method and application of the composite sun-screening agent. The preparation method of the composite sun-screening agent comprises the following steps: fully dispersing hydroxyapatite nanoparticles in an alkaline solvent, adding a dopamine monomer, and carrying out oxidative polymerization reaction, centrifugal washing and drying to obtain HAP-PDA composite nanoparticles; and fully dispersing the HAP-PDA composite nanoparticles in a solvent, adding a mixed solution of a chemical sun-screening agent and an antioxidant and a surfactant, and performing encapsulation reaction and centrifugation to obtain the product. According to the invention, a polydopamine and hydroxyapatite composite encapsulation technology is innovatively adopted, so that the stability and biocompatibility of the sun-screening agent and the antioxidant are remarkably improved, the sun-screening effect is enhanced, and the product is endowed with a lasting sun-screening effect and excellent oxidation resistance. According to the invention, the limitation of a traditional sunscreen product is broken through, and safer, more efficient and more comfortable sunscreen experience can be provided for consumers.

The invention discloses spirulina protein-zein composite nanoparticles and a preparation method and application thereof.The preparation method comprises the steps that a zein solution is added into a spirulina protein solution, ethanol in the solution is removed through evaporation, insoluble substances are removed through centrifugation, and spirulina protein-zein composite nanoparticle dispersion liquid is obtained; and freeze-drying to obtain spirulina protein-zein composite nanoparticle powder. The preparation method of the spirulina protein-zein composite nano-particles is simple, low in cost, green and safe, and the obtained nano-particles can be kept stable in a neutral pH environment, have good biocompatibility, can be applied to efficient embedding of bioactive components, and have good application prospects. The light, heat and storage stability of the bioactive components are remarkably improved; and the oxidation resistance, tyrosinase inhibition and in-vitro release performance of the bioactive components are improved.

The application provides a denitration and CVOCs removal encapsulated bifunctional molecular sieve catalyst and a preparation method and application thereof. y The composite nanoparticle is a core, and the hierarchical porous molecular sieve is a shell layer x -BO y The hierarchical porous-zeolite bifunctional molecular sieve catalyst is prepared by coupling two methods of reverse microemulsion and one-pot two-step dry gel conversion. The catalyst exhibits excellent NO x / CVOCs cooperative catalytic removal activity and stability in a medium-low temperature range (180-520 DEG C), and is suitable for simultaneous purification and removal of NO x and CVOCs in flue gas of waste incineration power generation and hazardous waste incineration pyrolysis industries. The catalyst preparation method is simple, can improve the flue gas pollutant purification efficiency, reduce the industry operation energy consumption and save the production cost.

The invention provides a nano-composite trace element fertilizer, a preparation method and an application system, the nano-composite trace element fertilizer is a composite trace element fertilizer nano-suspension, and trace element fertilizer composite nanoparticles are suspended in a composite trace element fertilizer clear liquid to form the composite trace element fertilizer nano-suspension; the nanoscale microelement fertilizer has a huge specific surface area, and can greatly improve the absorption and utilization efficiency of microelements; the source of the trace element fertilizer is expanded, not only can trace element salt be used, but also oxides (in a stone state) and simple substance metals (hard blocks) of specific trace elements can be converted into the trace element fertilizer; the slow release time is set according to different application scenes, so that the use convenience is improved; the nanoscale microelement fertilizer can be matched with an organic fertilizer, a compound fertilizer, a water flush fertilizer, an insecticide, a pesticide and the like for use, and can also be applied to a water and fertilizer integrated system; the nanoscale trace element fertilizer has water insolubility, reduces the influence of environmental factors such as raining and the like, and has higher utilization efficiency.

This invention provides a method for preparing a daidzein nanoparticle delivery carrier, belonging to the field of food processing technology. Using zein, carrageenan, and sodium alginate as raw materials, this invention utilizes ultrasound technology to construct a novel nanoparticle delivery carrier: zein nanoparticles loaded with a carrageenan / sodium alginate bistabilized layer, thereby improving the stability and bioavailability of daidzein nanoparticles. The advantages of this invention lie in the simplicity and environmental friendliness of the antisolvent precipitation method and ultrasound technology. The prepared composite nanoparticles possess stable physicochemical properties, small particle size, relatively concentrated particle size distribution, and high bioavailability. This invention enhances the practical application value of daidzein-loaded proteoglycan nanoparticles in the food processing industry and provides a theoretical basis for the application of daidzein nanoparticle oral delivery systems.

The invention discloses a Pickering emulsion with stable starch-myricetin composite nanoparticles and a preparation method of the Pickering emulsion, and belongs to the technical field of starch modification and emulsion delivery. Starch and myricetin are combined and compounded, a dynamic high-pressure microjet homogenization technology is introduced, the starch-myricetin composite nano-particles capable of stabilizing Pickering emulsion are obtained through a one-step method, and the application limitation that nano-starch is high in hydrophilicity, high in digestibility and the like is effectively solved; the prepared starch-myricetin composite nanoparticles have the characteristics of high stability and slow digestion function; the Pickering emulsion is prepared by further matching with a compound oil phase of coconut oil and cinnamon essential oil, so that the problem of coconut oil solidification can be effectively solved, and the Pickering emulsion has an antibacterial effect.

The invention belongs to the technical field of membranes, and particularly relates to an oil stain self-cleaning composite filtering membrane as well as a preparation method and application thereof. The oil stain self-cleaning composite filtering membrane provided by the invention comprises a polyvinylidene fluoride porous basement membrane, and CoFe2O4 (at) PDA composite nanoparticles are enriched on one side of the polyvinylidene fluoride porous basement membrane; the CoFe2O4-coated PDA composite nanoparticle has a core-shell structure, an inner core is a CoFe2O4 nanoparticle, and a shell layer coating the surface of the inner core is polydopamine; the surface of one side of the oil stain self-cleaning composite filtering membrane, which is enriched with the CoFe2O4 (at) PDA composite nanoparticles, is provided with an uneven rough structure. The oil stain self-cleaning composite filtering membrane has high-efficiency oil-water separation capability, stable anti-fouling performance and high-efficiency self-cleaning capability.

The invention belongs to the technical field of food packaging materials, and particularly relates to a Co-MOF (at) CEO intelligent active packaging film and a preparation method and application thereof. Cinnamon essential oil is embedded in a cobalt-based metal organic framework to form composite nanoparticles with antibacterial and ammonia-sensitive functions, then the composite nanoparticles and potato starch are mixed, a film is formed through a solution casting method, and the intelligent active packaging film is obtained. According to the preparation method of the intelligent active packaging film provided by the invention, the water solubility of the potato starch packaging film is reduced, the prepared intelligent active packaging film has good antibacterial, antioxidant activity, mechanical and barrier properties and good sensitivity to ammonia, the freshness of meat can be monitored in real time only through the color change of the packaging film, and the method is suitable for large-scale popularization and application. The fresh-keeping and freshness visual monitoring of food such as fish meat and the like can be realized at the same time, and the method has a good application prospect in the field of intelligent active packaging.

The invention discloses difunctional nano drug-loaded eye drops for xerophthalmia and a preparation method of the difunctional nano drug-loaded eye drops, and belongs to the field of pharmaceutical preparation technologies and ophthalmology pharmacy. The core of the invention is to construct a composite nanoparticle which has a core-shell structure and has long-acting adhesion lubrication and targeted control drug release functions. The preparation method comprises the following steps: firstly, encapsulating a hydrophobic immunosuppressant such as cyclosporine A in a biodegradable pad polymer matrix such as polylactic acid-glycolic acid copolymer (PLGA) by an emulsification-solvent evaporation method to form a drug-loaded polymer nano core; through the exquisite integrated design of the structure and the function, collaborative targeted therapy of two core pathological links of'tear film instability 'and'immune inflammation' of xerophthalmia is achieved, the bioavailability of the medicine is remarkably improved, the medication frequency and eye irritation are reduced, and the curative effect of xerophthalmia is improved. A more efficient and safer administration scheme with better patient compliance is provided for clinical treatment of xerophthalmia.

The application discloses a kind of composite materials for 3D printing wild animal skeleton, which is composed of composite nanoparticles of calcium phosphate and hydroxyapatite, and is prepared by a combined method of biomimetic in-situ synthesis-solvent thermal phase inversion-spray drying method.The composite material has high specific surface area and excellent fluidity, and can be used for 3D printing wild animal skeleton, with broad market application prospect.

The invention provides nucleic acid base composite nano-particles and a preparation method thereof. The preparation method comprises the following steps: taking PDMA and an acrylate adenine monomer as raw materials, carrying out polymerization to obtain a diblock polymer, taking the diblock polymer and a coumarin monomer as raw materials, carrying out polymerization to obtain PA, and assembling the PA into a nucleated cross-linked nano-micelle; pDMA and an acrylate thymine monomer are used as raw materials and polymerized to obtain a block polymer, and the block polymer is assembled into the nano-micelle; and mixing the core cross-linked nano-micelles with the nano-micelles, and interacting to obtain the composite nano-particles. According to the preparation method disclosed by the invention, the core-crosslinked nano-micelle containing adenine is constructed, and the nano-micelle has poly (N, N-dimethylacrylamide) with a hydrophilic block, and the poly (N, N-dimethylacrylamide) can stably exist in an aqueous solution; and mixing the core-crosslinked nano-micelles with the nano-micelles to obtain the composite nano-particles through biologically excited nuclear-base interaction.

The invention relates to the technical field of coal gangue treatment, in particular to a method for preparing 45 mullite by using solid waste coal gangue, which comprises the following steps: crushing and screening the solid waste coal gangue, then carrying out microwave irradiation, after irradiation, feeding into a planetary ball mill for grinding and drying, adding a composite alkali solution, stirring and activating to obtain 45 mullite; the composite alkali solution is an aqueous solution formed by mixing NaOH and Na2CO3; adding an interface modifier and composite nanoparticles into the activated coal gangue powder to obtain modified powder; adding water, mixing, pugging, aging, carrying out static pressure molding, and maintaining the pressure to obtain a green body; and uniformly spraying an aqueous solution prepared from a mineralizing agent on the surface of the green body, pre-drying after spraying, carrying out segmented calcination, and cooling to room temperature to obtain the 45 mullicarb. The coal gangue is cooperatively treated through microwave irradiation, compound alkali activation, interface modification and a compound mineralizer, so that the problems of inertia of silicon-aluminum components and poor interface compatibility of the coal gangue are solved, and solid waste resource utilization is realized.

A process for forming composite nanoparticles includes (a) mixing a first liquid with water, the first liquid comprising nanocrystal, hydrophobic organic molecule, or a combination thereof, and an organic solvent, forming particle core comprising the nanocrystal, hydrophobic organic molecule, or a combination thereof suspended in the water; and (b) mixing the particle core suspended in water with a second liquid, the second liquid comprising a stabilizer and the organic solvent, stabilizing the particle core comprising the nanocrystal, hydrophobic organic molecule, or a combination thereof with the stabilizer, and forming the composite nanoparticles. A time delay between steps (a) and (b) is about 2 millisecond (ms) to about 1 second.

This invention discloses a dual-emission molecularly imprinted ratiometric fluorescence sensor, its preparation method, and its application in the detection of chlortetracycline, belonging to the field of chemical sensor technology. The preparation method of this sensor includes the following steps: preparing silica-quantum dot composite nanoparticles; preparing a molecularly imprinted polymer using salicylamide as a template molecule; and using a post-mixing strategy to mix the molecularly imprinted polymer and silica-quantum dot composite nanoparticles in HEPES buffer to construct the dual-emission molecularly imprinted ratiometric fluorescence sensor. The advantages of this invention are: the dual-emission molecularly imprinted ratiometric fluorescence sensor provided by this invention exhibits rich fluorescence color changes, enabling rapid, highly sensitive, and visual detection of chlortetracycline; and the entire detection process is simple, convenient, and fast, making it suitable for widespread application in practical applications.

The invention discloses a preparation method of zein-starch Pickering emulsion loaded with daidzein and relates to the technical field of emulsion preparation, waxy corn starch is subjected to enzymolysis through pullulanase and is applied to emulsion construction, and the emulsion with good stability is researched to realize efficient loading. The invention also discloses a zein-short amylose composite nanoparticle, a preparation method of a Pickering emulsion stabilized by the composite nanoparticle, and the Pickering emulsion stabilized by the composite nanoparticle. The Pickering emulsion with stable composite nanoparticles prepared by the invention has the characteristics of high stability and high safety, and provides a substitute with a good application prospect for the transportation of a bioactive substance daidzein.

The present invention relates to an antimicrobial composite comprising a cationic antimicrobial compound and a bacterial enzyme degradable anionic copolymer wherein the bacterial enzyme degradable anionic copolymer and the cationic antimicrobial compound are linked to each other by electrostatic interaction. The invention also relates to a pharmaceutical composition comprising the antibacterial composite; a method of treating a subject suffering from a bacterial and / or fungal infection, comprising the step of administering to the subject a therapeutically effective amount of an antibacterial composite or pharmaceutical composition; the use of an antimicrobial composite in the preparation of a medicament for the treatment of bacterial and / or fungal infections in a subject in need of an antimicrobial composite; the use of the antibacterial composite or pharmaceutical composition for the treatment of bacterial and / or fungal infections; the invention also provides a method for preparing the antibacterial composite material.

According to the light-storing cement-based material and the preparation method thereof, through the synergistic effect of multiple light-emitting systems of the zinc sulfide particles, the strontium aluminate and the waste luminous ceramic powder, the light-emitting performance of high brightness and long afterglow is achieved, and the afterglow time can reach 12 hours or above; by adding the Fe3O4 / C composite nanoparticles, the light absorption efficiency and the energy conversion rate of the material are remarkably improved, and the luminous intensity is improved by more than 2 times compared with that of the traditional light storage cement; meanwhile, a three-dimensional light-transmitting network constructed by the light-transmitting glass aggregate and the organic transparent fiber tubes not only ensures the structural strength of the material, but also realizes efficient transmission and uniform luminescence of light; in addition, waste noctilucent ceramic powder is used as a raw material, so that the production cost is reduced, resource recycling is realized, remarkable environmental protection benefits are achieved, and the light storage cement can be widely applied to the fields of building decoration, road marking, emergency lighting and the like.

The invention provides a preparation method of HER2 targeted composite nanoparticles conjugated with a blood vessel disrupting agent, which comprises the following steps: grafting water-soluble azide-terminated poly (L-glutamic acid) with methoxy polyethylene glycol (NPLG-g-mPEG) to increase the number of effective load binding sites, bonding a cytotoxic drug SN38 with NPLG-g-mPEG through Steglich esterification reaction to obtain N3-PLG-SN38, and then adding the N3-PLG-SN38 into the HER2 targeted composite nanoparticles conjugated with the blood vessel disrupting agent to obtain the HER2 targeted composite nanoparticles conjugated with the blood vessel disrupting agent. According to the present invention, the Fc-PLG-SN38 is obtained by carrying out click chemical bonding on the Fc-III-4C peptide and the N3-PLG-SN38, by using the high affinity between the Fc-III-4C peptide and the Fc of the HER2 antibody, the antibody and the Fc-NPLG-SN38 are mixed in the water environment so as to obtain the HER2-PLG-SN38, and the HER2-PLG-SN38 and the blood vessel disrupting agent CA4P are conjugated so as to enhance the penetrating power and the drug effect on tumor cells;

The invention relates to the technical field of toy materials, in particular to antibacterial and mildewproof plasticine and a preparation method thereof, and the antibacterial and mildewproof plasticine specifically comprises the following components in parts by weight: 40-50 parts of starch, 20-25 parts of glycerol, 3-5 parts of polyethylene glycol, 0.5-0.8 part of an emulsifier, 5-8 parts of sodium chloride, 5-8 parts of hydrogen peroxide, 0.1-0.3 part of potassium sorbate, 0.2-0.3 part of phenoxyethanol, 3-7 parts of a composite nanoparticle material and 15-20 parts of water. The plasticine mostly adopts food-grade raw materials, is non-toxic and harmless, can guarantee the safety of a user, can reduce the allergy risk of children, can effectively inhibit bacterium breeding and avoid mildewing and deterioration of the plasticine by adding potassium sorbate, is suitable for long-term storage or multi-user use scenes, and has a good market prospect. In addition, a special composite nano-particle material is adopted as a carrier to load phenoxyethanol, so that the antibacterial aging can be effectively prolonged, and the long-term antibacterial effect is realized.

The invention belongs to the technical field of functional food and active substance delivery, and relates to EGCG (epigallocatechin gallate) loaded protein-polysaccharide ternary composite nanoparticles and a preparation method thereof. Zein is used as carrier protein, Arabic gum is used as stable polysaccharide, and an anti-solvent precipitation method is combined with ultrasonic treatment to prepare the composite nanoparticles. The preparation method specifically comprises the following steps: dissolving zein in an ethanol water solution to form an organic phase, dissolving Arabic gum in a water phase, adding the water phase into the organic phase under a stirring condition, removing ethanol to obtain a zein-Arabic gum binary composite nanoparticle dispersion liquid, introducing EGCG, and carrying out ultrasonic-assisted loading and drying to obtain a target product. The encapsulation efficiency of the active substance is improved through the ultrasonic-anti-solvent synergistic effect, the thermal stability and storage stability of the system are improved, and the method is simple, good in repeatability and suitable for delivery of food-grade active ingredients.

This invention belongs to the field of functional food technology, specifically relating to an astaxanthin and collagen complex composition and its preparation method. The composition comprises the following components: 5 to 20 parts of astaxanthin phospholipid composite nanoparticles, 60 to 110 parts of glycosylated collagen peptides, 2 to 6 parts of hyaluronic acid-collagen peptide grafts, and 1 to 3 parts of curcumin-encapsulated components. The preparation method of the composition is as follows: S1, preparing an activated aqueous phase base; S2, sequential mixing and primary stabilization; S3, integrating the encapsulated components and fine homogenization; S4, final blending and degassing; S5, solid particle preparation. This invention, by constructing a synergistic system containing multiple modified functional components such as astaxanthin phospholipid composite nanoparticles and glycosylated collagen peptides, and employing a refined compounding process, effectively improves the physical stability of the product and synergistically enhances the bioavailability of the active ingredients and the overall antioxidant support efficacy.

The application belongs to the technical field of semiconductor gas sensitive material and sensor, and particularly relates to a selective gas sensitive material for a complex gas environment and a preparation method and application thereof. The gas sensitive material takes WO3 nanofiber as a substrate, composites ZnO nanoparticles on the surface of the substrate, and loads noble metal Ir to form an Ir-ZnO / WO3 ternary composite structure. The composite structure is obtained by adding WO3 nanofiber prepared by an electrospinning method, ZIF-8 precursor and Ir nanoparticles into an anhydrous ethanol solution, and then performing ultrasonic treatment and drying, and finally calcining under an air atmosphere. The material and the sensor exhibit high sensitivity and high selectivity to BTXs, and have good anti-interference ability and stability, and are suitable for real-time monitoring and early warning of BTXs leakage in a complex industrial site with multiple gas interference such as petrochemical industry and waste treatment.

The application provides a modified ethylene-propylene rubber composite material for a high-speed train cable terminal and a preparation method and application thereof, and relates to the technical field of cable insulation materials.The modified ethylene-propylene rubber composite material is prepared from the following raw materials in parts by weight: ethylene-propylene rubber 100 parts, polydopamine-coated ZnO and BaTiO3 composite nanoparticles 10-30 parts, reinforcing agent 20-40 parts, plasticizer 5-15 parts, anti-aging agent 1-5 parts, vulcanizing agent 1-5 parts, and vulcanization accelerator 1-5 parts.The modified ethylene-propylene rubber composite material prepared by the application has good nonlinear electric conductivity and dielectric properties, good corona resistance, and excellent mechanical properties, and meets the high-standard requirements of the insulation material for the vehicle-mounted cable terminal.

The application belongs to the technical field of polymer composite materials, and relates to a solar-driven interface water evaporation and photocatalytic dye degradation bifunctional composite fiber membrane and a preparation method thereof. A polyarylene ether nitrile nanofiber membrane is prepared through an electrostatic spinning technology, polyaniline / titanium dioxide composite nanoparticles are prepared through an in-situ polymerization method, and finally, the polyaniline / titanium dioxide composite nanoparticles are loaded on the surface of the polyarylene ether nitrile fiber membrane through a polydopamine-assisted vacuum self-assembly method, so as to obtain a polyaniline / titanium dioxide / polyarylene ether nitrile composite fiber membrane. The prepared polyaniline / titanium dioxide / polyarylene ether nitrile composite fiber membrane has a high evaporation rate and a good dye removal rate, and has a wide application prospect in water resource purification and industrial wastewater treatment.

The invention discloses a preparation method and a preservation method of an FA-Se-coated SNCsNPs / starch / gelatin composite film, and the preparation method comprises the following steps: (1) synthesizing selenium nanoparticles (SeNPs) through a chemical method by taking Vc as a reducing agent and sodium selenite as a selenium source; (2) preparing selenium nanoparticles (Se (at) SNCsNPs) loaded on starch nanocrystals (SNC); (3) adding ferulic acid into the product obtained in the step (2) to prepare composite nanoparticles (FA-Se-SNCsNPs) with a synergistic interaction effect; (4) adding the nanoparticles prepared in the steps (1), (2) and (3) as a filler into a starch / gelatin composite matrix membrane solution; and (5) smearing each coating liquid on the Zaosu pears for preservation. According to the method, the stability of the selenium nanoparticles is realized, the oxidation resistance of the selenium nanoparticles is improved, and the phytotoxicity of precipitation or aggregation caused by unstable particles on the Zaosu pears is avoided in the process of prolonging the quality of the harvested Zaosu pears.

This invention provides a modified ferroelectric polymer composite film, its preparation method, and its applications, belonging to the field of piezoelectric composite material technology. The modified ferroelectric polymer composite film includes a ferroelectric polymer base film and a plurality of composite nanoparticles and multi-walled carbon nanotubes dispersed within the ferroelectric polymer base film. The composite nanoparticles have a core-shell structure, comprising a core and an inner shell layer and an outer shell layer sequentially surrounding the core. The core comprises a composite piezoelectric ceramic material composed of potassium sodium niobate and barium titanate, the inner shell layer comprises polydopamine, and the outer shell layer comprises MnO2. This invention fully utilizes the synergistic effect of the composite nanoparticles and multi-walled carbon nanotubes on the dielectric and piezoelectric properties of P(VDF-TrFE) materials, thereby preparing a composite material with high dielectric constant, low dielectric loss, and excellent piezoelectric properties to meet the stringent performance requirements of high-performance sensors and other application fields.

The invention provides saCNTF-DSF-LNP composite nanoparticles as well as a preparation method and application of the saCNTF-DSF-LNP composite nanoparticles, and particularly relates to application of the saCNTF-DSF-LNP to preparation of medicines for treating diseases related to optic nerve injury. The method comprises the following steps: S1, preparing self-amplification CNTF RNA, and naming the self-amplification CNTF RNA as saCNTF; s2, preparing lipid nano particles entrapped with the disulfiram DSF; s3, quickly adding the ethanol phase containing the disulfiram DSF-lipid mixture into the aqueous phase containing the saCNTF, and mixing, so that the nanoparticles are formed by self-assembly; s4, purifying the nano particles by using an ultrafiltration centrifugal device to obtain saCNTF-DSF-LNP; the invention provides a preparation method and application of saCNTF-DSF-LNP, the saCNTF-DSF-LNP can inhibit neuroinflammation driven by acute pyroptosis, and continuous neurotrophic support is provided for RGC survival and long-term axon regeneration; according to saCNTF-DSF-LNP, continuous expression of CNTF is achieved through saRNA, efficient targeted delivery is achieved by means of LNP so as to reduce off-target toxicity of DSF, and a new treatment strategy is provided for neuritis and degenerative diseases.