1093 results about "Composite nanoparticles" patented technology

Size-confined nanocomposite powders and methods for their manufacture are provided by coating fine powders with a nanoscale powder of a different composition. The nanocomposite plastics disclosed offer performance characteristics approaching those of metals and alloys. The nanocomposite powders are alternatively used for dispersion strengthening of metals, alloys, and ceramics. Novel materials based nanotechnology for energy devices and programmable drug delivery are disclosed.

The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.

A composite magnetic nanoparticle drug delivery system provides targeted controlled release chemotherapies for cancerous tumors and inflammatory diseases. The magnetic nanoparticle includes a biocompatible and biodegradable polymer, a magnetic nanoparticle, the biological targeting agent human serum albumin, and a therapeutic pharmaceutical composition. The composite nanoparticles are prepared by oil-in-oil emulsion / solvent evaporation and high shear mixing. An externally applied magnetic field draws the magnetic nanoparticles to affected areas. The biological targeting agent draws the nanoparticles into the affected tissues. Polymer degradation provides controlled time release delivery of the pharmaceutical agent.

The invention relates to a preparation method of a hollow mesoporous silica nanoparticle. The preparation method comprises the following steps: obtaining a polymer-silica composite nanoparticle having a core-shell structure by adopting spherical aggregations of an amphiphilic segmented copolymer in an aqueous solution and a cationic surfactant hexadecyl trimethyl ammonium bromide as double templates and ethyl orthosilicate as a silicon source and by hydrolyzing the silicon source under an alkaline condition; and calcining to remove the templates to obtain the hollow mesoporous silica nanoparticle. The preparation method has the advantages of simplicity, mild reaction condition, and cheap experiment raw materials, and the prepared mesoporous silica nanoparticle has the advantages of high specific surface area, high pore volume, and good biological compatibility. The hollow structure enables the drug loading amount to be substantially improved, nanometer gold, nanometer silver, magnetic iron oxide particles, quantum dots, a contrast agent and the like to be loaded, so the hollow mesoporous silica nanoparticle can be used as a targeting drug release carrier, can be used for magnetic resonance image analysis, and has good application prospects in the fields of the diagnosis and the treatment of cancers.

The invention discloses a composite with an adsorption-visible light catalytic degradation synergistic effect and a preparation method and application thereof. The preparation method includes the specific steps that firstly, a bismuth oxyiodide / bismuth oxychloride composite nano-particle loaded activated carbon fiber composite ACF@BiOIxCl1-x is synthesized; then, the fiber surface is grafted with polyethyleneimine, and the end composite PEI-g-ACF@BiOIxCl1-x is obtained. The composite can rapidly adsorb pollutants in water, and meanwhile the pollutants are efficiently degraded with a photocatalyst loaded on the surface of the composite; besides, the purpose of recycling and reusing the photocatalyst is achieved, the comprehensive treatment capability of the composite is improved, the service life of the composite is prolonged, and the use cost is lowered.

A method of forming mono-disperse iron-oxide core metal shell nanoparticles is disclosed. Particle size of the oxide core seeds is controlled and capped seeds are formed. The capping layer is desorbed by a thermally activated process and metal such as gold is chemically deposited on the core seeds in situ. This process can be repeated to produce multi-metal or different metal shells. A second capping layer is applied on the core / shell composite nanoparticles. In another step, the particles are sized by centrifuging to obtain a tightly controlled and narrow particle size distribution. The water-dispersibility of the particles is achieved by a thiol exchange reaction on the gold shell of the core / shell nanoparticles or by deposition of gold on ferritin-derived iron oxide cores in aqueous solution. Mono and multilayer thin films are assembled on different substrates using the core / shell particles and linking molecules.

A method of making a nanoparticulate based lubricant is disclosed. The method includes providing solid lubricant material with particles having a size less than or equal to about 500 nanometers, and treating the particles to create composite nanoparticles. The composite nanoparticles includes the solid lubricant material and at least a second material.

The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.

The invention discloses a PVB (polyvinyl butyral) film for dynamically rejecting infrared rays and resisting ultraviolet rays and a preparation method thereof. The functional PVB film comprises cesium tungsten bronze, antimony indium oxide, indium tin oxide, titanium dioxide, nano carbon spheres, zirconium carbide, PVB resin powder, a plasticizer, a trace improver and the like. The preparation method comprises the following steps: dispersing the cesium tungsten bronze composite nanoparticles with a solvent, adding the plasticizer, stirring uniformly, adding the PVB resin powder and trace improver, thoroughly mixing, and carrying out film formation on the mixture by running to obtain the heat-insulation ultraviolet-resistant PVB film. The ultraviolet rejection ratio of the PVB film is greater than 99.0%, the visible light transmittance is adjustable within the range of 60-85%, and the infrared rejection ratio is up to 80-99%; and the PVB film can be directly used for producing heat-insulation infrared / ultraviolet-resistant safety laminated glass, can be widely used in architectural curtain walls, doors / windows, zeniths, automobile windshields and the like, and is a novel energy-saving film material.

The present invention relates to a preparation method and an application of a hyaluronic acid-antitumor drug conjugate and composite nanoparticle composition with characteristics of active targeting antitumor effect and biodegradability. The preparation method is characterized by comprising: (1) a synthesis method for conjugating an antitumor drug and a spacer and conjugating a targeting ligand hyaluronic acid or an ammonium salt thereof and the antitumor drug-spacer; and (2) a new technology for assembling the hyaluronic acid-antitumor drug conjugate and amphiphilic polyester block copolymer composite nanoparticles. The composition has effects of substantially increased drug loading, efficacy improving, in vivo long-circulating effect achievement, active tumor targeting property and drug toxic-side effect reduction. The macromolecular conjugate and complex nanoparticle composition can be used for injection administration, oral administration or mucosal administration. In addition, the preparation method has characteristics of mature process and high yield, and is suitable for industrial production.

The invention discloses a magnetic luminescent composite nano-particle Fe3O4 / CdTe / SiO2 and a preparation method thereof. The method for preparing the magnetic luminescent composite nano-particle Fe3O4 / CdTe / SiO2 comprises the steps of: firstly preparing hydrophobic monodisperse Fe3O4 nano-particles by adopting a chemical oil-phase high-temperature method, and modifying the surfaces of the hydrophobic Fe3O4 nano-particles to ensure that the hydrophobic Fe3O4 nano-particles are dispersed in a water phase; preparing luminescent CdTe quantum dots of which the surfaces are provided with carboxyl groups, and precipitating the luminescent CdTe quantum dots on the surfaces of the magnetic Fe3O4 nano-particles through the co-precipitation; then utilizing ligand exchange to modify a silane coupling agent on the surfaces of the luminescent CdTe quantum dots; and finally forming an outermost SiO2 coating layer through silane or silicon ester hydrolysis. The diameter of the magnetic luminescent composite nano-particle Fe3O4 / CdTe / SiO2 is between 30 and 50nm; the magnetic luminescent composite nano-particle Fe3O4 / CdTe / SiO2has double functions of magnetism and fluorescence at the same time, has strong and durable fluorescence intensity after labeling rat bone marrow-derived mesenchymal stem cells, and apparently reduces cellular magnetic resonance signals. The particle has broad application prospect in the fields such as biological labeling, bioseparation and the like.

The invention relates to a dual emission rate type fluorescent probe for visually detecting carbon dots-Au nanoclusters of mercury ions and a preparation method. Dual-emission composite silicon dioxide nanoparticles are composite silicon dioxide nanoparticles formed by utilizing carbon dot covered silicon dioxide particles as cores and covalently coupling the surfaces of the carbon dot covered silicon dioxide particles with the Au nanoclusters after surface amination. The carbon dots located in the silicon dioxide nanoparticle cores are taken as reference fluorescence signals, the Au nanoclusters on the outer layers are taken as response fluorescence signals, and the signals are used for Hg<2+> selective recognition. The Au nanoclusters as the response fluorescence signals are connected to the surface of a silicon layer through covalent bond connection, and one stable nano-fluorescent probe is formed. When the dual-fluorescence composite nanoparticles are taken as the rate type fluorescent probes, the intensity of the carbon dot fluorescence signals in the cores basically keep unchanged, and the Au nanoclusters on the outer layers can be bonded with Hg<2+> selectively so as to result in fluorescence quenching of the Au nanoclusters on the outer layers.

The present invention provides a method of synthesizing nanosized abrasive particles and methods of using the same in chemical mechanical polishing slurry applications. The nanosized abrasive particles according to the invention are produced by hydrothermal synthesis. The crystallites of the particles include cerium atoms and atoms of metals other than cerium. In a preferred embodiment of the invention, the crystallites exhibit a cubic crystal lattice structure. The differences in electric potential between the cerium atoms and the atoms of metals other than cerium facilitate the polishing of films without the need for chemical oxidizers.

A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage / delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.

The invention discloses a method for preparing an intelligent nanometer oil-displacing agent. The method comprises the following steps: grafting a temperature-sensitive polymer, a hydrophilic polymer and a hydrophobic polymermer to the surfaces of nanoparticles by virtue of a covalent bond so as to prepare composite nanoparticles with temperature sensitive characteristic; and compounding the composite nanoparticles with alkali and surfactants, thereby obtaining the intelligent nanometer oil-displacing agent with temperature response characteristic. The nanometer oil-displacing agent has the characteristics that according to change of displacing fluid along with temperature in the using process, the hydrophilic and oleophylic performances of the nanometer oil-displacing agent can be regulated. The formation temperature is high, the nanometer oil-displacing agent is oleophylic, crude oil is conveniently stripped from the rock surface, and the recovery ratio is improved. The formation temperature is low, the nanometer oil-displacing agent is hydrophilic, and oil-water separation can be rapidly realized without a demulsifying agent. Moreover, the sizes of the nanoparticles correspondingly change along with temperature difference, and controllable dual effects of plugging and profile control and plug removal are achieved in the formation.

In one embodiment, the invention provides a positive electrode protective material of a lithium sulfur battery. The material includes a nano-porous carbon network and inorganic nano-particles uniformly distributed therein. Distance of any two adjacent inorganic nano-particles is 3-50 nm. The inorganic nano-particles are metal compound nano-particles or metal-metal compound composite nano-particles. The nano-porous carbon network and the inorganic nano-particles can form an integrated three-dimensional nano-porous composite network. The positive electrode protective material has physical and chemical dual-adsorption effect and can constrain lithium polysulfide to nearby the positive electrode, thus effectively inhibiting loss of a positive active material in the lithium sulfur battery. Meanwhile, the material can accelerate conversion from soluble lithium polysulfide to indissolvable Li2S2 or Li2S, thus greatly improving energy conversion efficiency and rate capability of the lithium sulfur battery and achieving excellent cycle performance under high energy density. The invention also provides a practical application of the positive electrode protective material in the lithium sulfur battery.

The invention discloses a paper-based micro-fluidic immunosensor chip and a timely field detection immunoassay platform. According to the paper-based micro-fluidic immunosensor chip, a micro-fluidic channel is constructed on a paper base, and a reaction area in the channel is subjected to surface modification, so that chemical crosslinking is carried out on the channel and an antibody, and the antibody is fixed on the surface of the paper base. The chip washing is needed to be combined with a ring oven, the washing and flow velocity are controlled by the ring temperature, and the problems of the conventional paper-based micro-fluidic chips at home and abroad on washing and flow velocity control are solved. Another cluster marker labeled antibody which is specifically combined with an antigen and takes mesoporous silica or metallic oxide-silica composite nanoparticles as a matrix is detected by adopting manners of mobile phone photographing, image scanning and collecting or laser-induced fluorescence, so that the content of antigen to be detected is detected. According to the paper-based micro-fluidic immunosensor chip, the detection sensitivity is obviously improved.

The invention discloses a titanium dioxide / lignin-based composite nanoparticle, and a preparation method and application thereof, belonging to the technical field of composite nanoparticles. The method provided by the invention comprises the following steps: adding a quaternization reagent into an alkaline alkali lignin solution for a reaction so as to obtain quaternized lignin; subjecting the quaternized lignin to acid regulation, adding an anionic surfactant so as to obtain a quaternized lignin / anionic surfactant compound, and adding the compound into an ethanol suspension of nanometer titanium dioxide so as to obtain a mixed solution of titanium dioxide / lignin-based compound; and adding water with a pH value of 1 to 7 into the mixed solution and carrying out ageing so as to obtain titanium dioxide / lignin-based composite nanoparticle. The composite nanoparticle is low in cost, uniform in particle size, good in dispersibility and strong in compatibility with organic mediums; when applied to skin care products and anti-UV materials, the composite nanoparticle can substantially improve anti-UV capability; and titanium dioxide wrapped by the lignin-based compound can effectively shield the photocatalytic activity of the composite nanoparticle and improve the photostability of the composite nanoparticle.

Metal nanoparticles associated with a spectroscopy-active (e.g., Raman-active) analyte and surrounded by an encapsulant are useful as sensitive optical tags detectable by surface-enhanced spectroscopy (e.g., surface-enhanced Raman spectroscopy).

The invention discloses a graphene-fullerene-like molybdenum disulfide compounded lubricating oil additive and a preparation method thereof. The method is implemented by taking oxidized graphene and fullerene-like molybdenum disulfide nanoparticles as raw materials through carrying out surface grafting on oxidized graphene nanoparticles by using lipophilic 3-(methyl acryloyl oxy) propyl-trimethoxysilane (KH-570), and carrying out reduction by using hydrazine hydrate, so that grafted graphene nanoparticles are formed; wrapping the fullerene-like molybdenum disulfide nanoparticles with polystyrene (PS), so that PS / IF-MoS2 nano composite microspheres are formed; and finally, inducing KH-570 and PS to have a polymerization reaction, so that graphene-fullerene-like molybdenum disulfide compounded nanoparticles are formed. The compounded nanoparticles prepared according to the invention are used as a lubricating oil additive, and can be steadily dispersed in lubricating oil for a long time, and various organic dispersants are not required to be added.

There is provided composite nano-particles comprising nano-crystal particles dispersed stably and individually in suspension in high concentration without mutual aggregation of the nano-particles. A determined amount of pure water or deionized water is poured into a reactor, into which is introduced nitrogen gas at rate of 300 cm3 / min for a given time while agitating with a stirrer to remove dissolved oxygen in the pure water, allowing to stand in an atmosphere of nitrogen. Next, the inside of the reactor is maintained in an atmosphere of nitrogen and sodium citrate as a dispersion-stabilizing agent, an aqueous solution of MPS as a surface-modifying agent, an anion aqueous solution for co-precipitation as a nano-crystal and a cation aqueous solution are added, in that order. Then, an aqueous solution of sodium silicate is added to the reactor, which is then allowed to stand in the dark place in an atmosphere of nitrogen after agitation. At that time, a vitrification-inhibiting agent may be added in order to inhibit the growth of glass layer.

The invention discloses a preparation method of a medical metal surface slow-released growth factor coating. The method comprises the steps of firstly, using graphene oxide as the growth factor carrier, wrapping growth factors in composite nano granules formed by polycations and polyanions, reacting the nano granules containing the growth factors with the carboxylated graphene oxide so as to form amido bonds, thereby fixing the nano granules on the graphene oxide; and enabling the graphene oxide carrying the growth factors to form the coating on a biologic medical metal surface which is subjected to dopamine treatment by using an extraction method. By utilizing the preparation method, higher growth factor carrying quantity is realized, and meanwhile, the activity of the factors is protected, and the slow-releasing of the factors is realized.

Disclosed are amorphous carbon nanofibers including copper nanoparticles or copper alloy nanoparticles, copper composite nanoparticles prepared by grinding the amorphous carbon nanofibers and implemented as surfaces of Cu-included particles are partially or wholly coated with amorphous carbons, a dispersed solution including the copper composite nanoparticles, and preparation methods thereof and the amorphous carbon nanofibers include nanoparticles including copper, copper nanoparticles or copper alloy nanoparticles, and, the copper composite nanoparticles are implemented as surfaces of Cu-included particles are partially or wholly coated with amorphous carbons.

The invention discloses a surface plasma fluorescence-enhanced nano composite structure film, which has the components of SiO2 with amino and composite nanoparticles with a nano composite structure, wherein the cores of the composite nanoparticles are metal nanoparticles, and the outer layers are quantum dots; and the metal nanoparticles are connected with the quantum dots through a SiO2 layer with the thickness of 4 to 30nm. The surface plasma fluorescence enhancement effect caused by the nano composite structure in the film makes fluorescence quantum efficiency of the quantum dots in the film greatly improved and the scintillation effect thereof eliminated. The invention also discloses a method for preparing the film. The nano composite structure film prepared by the method overcomes the defects of the quantum dots, which has great significance for applying the quantum dots in medicaments, biological detection, photoelectric conversion and Raman scattering, particularly using the quantum dots as single photon source in the field of quantum dot coding.

The invention belongs to the field of preparing a nanomaterial, and particularly relates to a magnetic fluorescent double-function nanoion probe and a preparation method thereof. The composite microparticles have the fluorescent performance of quantum dots and the magnetism performance of magnetic nanoparticles, and can be used as target positioning in biological body and biological fluorescent imaging aspects. The invention provides a preparation method of the magnetic fluorescent double-function nanomaterial, and the magnetic fluorescent double-function nanomaterial is obtained by taking chitosan-modified magnetic nanoparticles as a core and connecting water-soluble quantum dots through adopting an ionic crosslinked method, the fluorescent quantum dots are distributed on the surfaces of the magnetic nanoparticles with the particle size of 10-200nm, and the particle size of the quantum dots is 1.5-10nm. The preparation method is mild in reaction conditions, the operation method is simple, the prepared composite nanoparticles have good luminescence performance and magnetic performance, and have wide application prospects in the fields of biomarking, fluorescent immunoassay, bioseparation, protein DNA enrichment and separation, the preparation of drug carrying system, and target imaging and the like.

The invention discloses a preparation method of a composite luminescent fiber nanomaterial. The preparation method comprises the steps: reacting a rare earth complex or a rare-earth-doped nanocrystal with a polymer monomer to form a core-shell structured compound; demulsifying, separating and drying the compound to obtain a rare-earth complex-polymer or rare-earth-doped nanocrystal-polymer composite nanoparticle powder; and preparing the composite nanoparticle power into an electrospinning solution, and preparing the electrospinning solution into the composite luminescent fiber nanomaterial with an electrospining method. The invention provides a new approach to preparation of a rare-earth organic-inorganic composite fiber nanomaterial with good dispersity, high orientation property, strong chemical stability and high luminous efficiency. The composite luminescent fiber nanomaterial is about to achieve important application values in the fields of optical communication, laser, communication and transportation, sailing fire fighting, raining working, bioinstrumentation and biochip, submarine signal transmission and solar photovoltaic cells.

The invention discloses a gold nanocage-manganese dioxide composite nanoparticle as well as a preparation method and application thereof, and relates to the technical field of nanoparticle photodynamic therapy. The composite nanoparticle comprises a gold nanocage inner core and a manganese dioxide shell layer. The preparation method is characterized in that potassium permanganate is reduced by a one-step reduction method; the manganese dioxide shell layer covers the surface of the gold nanocage, wherein the gold nanocage inner core achieves a photodynamic curative effect under the triggering of near-infrared light; the manganese dioxide shell layer is degraded in tumor microenvironment and releases oxygen, so that the tumor oxygen deficiency is relieved, and the photodynamic curative effect is enhanced; on the other hand, the opto-acoustic and magnetic resonance bimodule imaging can also be realized. The problem of insufficient photodynamic curative effect caused by factors such as tumor oxygen deficiency and photodynamic oxygen consumption of a nanometer photosensitizer used in the prior art is solved. The photodynamic curative effect of the gold nanocage-manganese dioxide composite nanoparticle is obvious; the gold nanocage-manganese dioxide composite nanoparticle can be applied to tumor targeted oxygenation photodynamic diagnosis and treatment integration.