396 results about "Silica nanoparticle" patented technology

The invention relates to the field of membrane materials, and discloses an epoxy modified starch-based degradable membrane and a preparation method thereof, the epoxy modified starch-based degradable membrane comprises epoxidized starch, modified nanocellulose and a plasticizer; the modified nano cellulose is prepared by mixing a modified composite filler, a nano cellulose dispersion liquid and a zinc acetate dihydrate aqueous solution; the nano-cellulose dispersion liquid is prepared by adhering polytannic acid formed by oxidation and self-polymerization of tannic acid to the surface of nano-cellulose; the modified composite filler is prepared by performing carboxylation modification on nano titanium dioxide coated fumed silica nanoparticles by using succinic anhydride and gamma-aminopropyltriethoxysilane, then reacting with polyethyleneimine to obtain an aminated composite filler, and finally grafting glycidyl dodecyl dimethyl ammonium chloride to the surface of the aminated composite filler. The prepared film material is high in tensile strength, has certain hydrophobicity, and has good heat resistance, antibacterial property and flame retardant property.

The invention relates to a catalyst for ethylene oxide ring-opening polymerization and a preparation method thereof, and belongs to the technical field of high polymer material synthesis, and the catalyst is a composite structure based on a silicon dioxide nanoparticle loaded bimetal organic complex; a modified nitrogen-containing polydentate ligand is prepared by adopting a special method, is coordinated with metal ions through covalent bonds and is loaded on silicon dioxide nanoparticles; by utilizing the high dispersity and stability of the silicon dioxide nanoparticles and the synergistic catalytic effect of the bimetal organic complex, the catalytic effect is effectively improved, the polymerization process is accelerated, the polymerization stability is enhanced, the polymerization molecular weight is improved, and the distribution is narrow.

Manganese-doped hollow mesoporous silica nanoparticles loaded with curcumin and an application in periodontal bone tissue repair are provided in the present disclosure, belonging to the technical field of targeted delivery of nanoparticles and bone tissue regeneration. In the present disclosure, alendronate is grafted on the surface of silica nanoparticles to achieve bone targeting, manganese is doped on the nanoparticles by a chemical method, and curcumin is wrapped in the nanoparticles.

The invention discloses an antibacterial corrosion-resistant coating and a preparation method thereof, and relates to the field of coating materials. The coating is prepared from the following components in percentage by mass: 2 to 5 percent of nano silver ion loaded mesoporous silicon dioxide nano particle antibacterial aid, 5 to 10 percent of zinc powder-containing corrosion inhibitor, 3 to 8 percent of nano montmorillonite, 30 to 40 percent of modified epoxy resin, 20 to 30 percent of polyurethane prepolymer and other aids. The nano silver ion antibacterial auxiliary agent is loaded in mesoporous silica nanoparticles through an ion exchange method, the zinc powder corrosion inhibitor is prepared through stirring and ball milling dispersion, and the modified epoxy resin is modified by adopting a silane coupling agent. The preparation process of the coating comprises the stages of premixing, grinding and refining, initiating polymerization and post-treatment, wherein a grinding medium is zirconium oxide beads with the diameter of 0.5-2 mm. The coating has excellent antibacterial and corrosion-resistant performance, is suitable for metal surface protection, and can effectively solve the problems that an existing coating is not lasting in antibacterial effect, insufficient in corrosion-resistant performance and not ideal in comprehensive performance.

The invention belongs to the technical field of environmental protection, and provides a preparation method of an imine-modified functionalized mesoporous magnetic silicon dioxide nano material. The method comprises the following steps: synthesizing Fe3O4 magnetic nanoparticles in a Fe < 2 + > / Fe < 3 + > alkaline hydrolysis system through a coprecipitation method; then coating the magnetic nanoparticles with an amorphous silicon dioxide layer by taking TEOS (tetraethoxysilane) as a silicon source by adopting a sol-gel method, so as to prepare magnetic silicon coated nanoparticles; the prepared nano-particles are subjected to secondary silicon coating guided by a cetyl trimethyl ammonium bromide (CTAB) mesoporous template agent, and mesoporous magnetic silicon nano-particles are formed after calcination; and finally, carrying out surface amination modification on the mesoporous magnetic silicon nano-particles by utilizing an amino silane coupling agent, and then carrying out condensation reaction on the mesoporous magnetic silicon nano-particles and various aldehyde derivatives to construct imine bonds, so as to obtain the imine-modified functionalized mesoporous magnetic silicon dioxide nano-material. The imine-modified functionalized mesoporous magnetic silicon dioxide nano-material formed by the invention has the characteristics of efficient adsorption, rapid magnetic recovery and excellent environmental stability, and can effectively remove polystyrene micro-plastics and organic pollutants in a water body.

The invention discloses a preparation method of a polyester fabric with antibacterial and hydrophobic properties, and belongs to the technical field of textile finishing. The method comprises the following steps: preparing silane modified silicon dioxide nanoparticles, compounding the silane modified silicon dioxide nanoparticles with a halamine antibacterial water repellent agent, preparing a monomolecular horizontal film in a steam atmosphere through Langmuir film formation, and finishing the monomolecular horizontal film on the polyester fabric through an LB method to enable the surface of the polyester fabric to have antibacterial and hydrophobic properties. The method has the advantages of simplicity in operation, high efficiency, controllable and controllable nanoparticle size and surface thickness, no need of baking treatment and the like, has small influence on the performance of the fiber, has good antibacterial and hydrophobic properties, and has wide prospects in the fields of self-cleaning, biomedicine and the like.

Described herein are compositions, systems, and methods for targeted and controlled drug release. In some embodiments, the compositions, systems, and methods may comprise magnetoelectric silica nanoparticles for targeted and controlled release of chemotherapeutic drugs for cancer treatment. In some embodiments, an external magnetic field may be used to release one or more drugs from the magnetoelectric silica nanoparticles. The disclosed compositions, systems, and methods may improve drug targeting and reduce systemic drug toxicity.

The invention relates to the technical field of metal corrosion protection. The invention provides a preparation method of an active self-repairing anticorrosive coating for a vibration sensor in a severe corrosion environment. The preparation method comprises the following steps: (1) preparing mesoporous silica nanoparticles; (2) preparing carboxyl cerium dioxide nanoparticles; (3) preparing an activated carboxyl cerium dioxide nanoparticle mixed solution; (4) preparing a triazindene-accelerant M solution; (5) preparing a mesoporous silica loaded carboxyl cerium dioxide nanoparticle coated indene and accelerant M filler; and (6) uniformly stirring the filler obtained in the step (5) with epoxy resin to obtain the active self-repairing anticorrosive paint. The invention further provides an active self-repairing anticorrosive coating for the vibration sensor in the severe corrosion environment and application of the active self-repairing anticorrosive coating. According to the anticorrosive paint prepared by the invention, the performances of high carrier loading capacity, strong corrosion inhibitor protection effect, high pH reaction rate and the like are improved, and the performance defects of a traditional self-repairing coating are made up.

The disclosure discloses peony bark essential oil silica nanoparticles and a preparation method and application thereof. The peony bark essential oil silica nanoparticles of the disclosure are prepared from mesoporous silica, peony bark essential oil, and chloroform in a solid-liquid ratio of 90-110 mg:50-150 μL:0.5-2 mL. In the disclosure, the peony bark essential oil is used as a main active ingredient, and the peony bark essential oil is loaded into mesoporous silica particles to prepare the peony bark essential oil silica nanoparticles. The peony bark essential oil silica nanoparticles are uniform in size, high in coating efficiency, and good in release performance. The mesoporous silica prepared in the disclosure may be effectively compatible with the peony bark essential oil, and may effectively improve an anti-mite effect of the peony bark essential oil while achieving slow release of the peony bark essential oil.

The invention discloses a high-light-transmittance heat-insulation super-hydrophobic composite coating as well as a preparation method and application thereof, and relates to the technical field of coating preparation. The composite coating provided by the invention comprises a heat-insulating coating positioned on a bottom layer and a super-hydrophobic coating positioned on a top layer, wherein the heat-insulating coating comprises a binder and heat-insulating material particles dispersed in the binder; the super-hydrophobic coating comprises a micro-nano composite structure composed of modified silicon dioxide nanoparticles and fumed silica nanoparticles, the modified silicon dioxide nanoparticles are silicon dioxide nanoparticles which are prepared through hydrophobic treatment and have the particle size of 80-150 nm, and the mass ratio of the modified silicon dioxide nanoparticles to the fumed silica nanoparticles with the particle size of 15-30 nm is (0.2-0.4) g: (0.1-0.2) g; according to the composite coating provided by the invention, the light transmittance and the hydrophobicity of the composite coating are synergistically improved by regulating and controlling the proportion of silicon dioxide with different scales while the light transmittance, heat insulation and surface super-hydrophobicity are realized.

The invention discloses a polyvinylidene fluoride (PVDF) super-hydrophobic membrane and a preparation method thereof.The preparation method comprises the steps that firstly, methyl sodium silicate, perfluorodecyl triethoxysilane (PFDTES) and tetraethoxysilane (TEOS) serve as catalysts / reactants, fluorinated hydrophobic modification is conducted on hydrophilic silicon dioxide (SiO2) nanoparticles, a nanoparticle non-solvent composite spraying synergistic phase inversion method is provided, and the polyvinylidene fluoride (PVDF) super-hydrophobic membrane is prepared. F-SiO2 is successfully introduced into the surface of the membrane, a multi-scale micro-nano structure is formed on the surface of the membrane, and the hydrophobicity and the surface roughness of the membrane are greatly improved. The prepared membrane is applied to vacuum membrane distillation testing, the flux and the salt rejection rate are very excellent, the maximum salt rejection rate reaches 99.99%, the flux is kept at 18.21 kg.m <-2 >. H <-1 > or above, the performance of the super-hydrophobic membrane is superior to that of a base membrane and a membrane prepared through a traditional non-solvent induced phase separation method, and the super-hydrophobic membrane has good anti-pollution performance and is very good in recovery effect after being washed with water.

The invention relates to the technical field of wind power and power grid equipment anti-icing, and discloses a fluorosilicone oil microcapsule anti-icing coating for wind power and power grid equipment. Comprising the following components which are independently subpackaged: a component A, namely a nano ceramic pre-dispersion: 20-30 parts of methyltrimethoxysilane, 5-8 parts of tetraethoxysilane, 40-60 parts of isopropanol and 10-15 parts of silicon dioxide nanoparticles with perfluoroalkyl grafted on the surfaces; the component B is microcapsule dry powder: 25-40 parts of mesoporous alumina microcapsules filled with fluorosilicone oil, 1-4 parts of amino modified carbon nanotubes and 2-5 parts of an oxygen vacancy defect type titanium dioxide photocatalyst, the microcapsules are triggered to release the fluorosilicone oil through the volume expansion rate of a thermal expansion layer and stress sensitive layer composite wall material at low temperature, and meanwhile, when ice pressure exists, the stress sensitive layer can release the fluorosilicone oil, so that the stress sensitive layer can release the fluorosilicone oil. And the polydopamine-coated aluminum oxide layer is elastically deformed to synergistically release the fluorosilicone oil to form a dual-mode anti-icing mechanism.

The application belongs to the technical field of functional coating materials, and particularly relates to a kind of super-hydrophobic solution based on fumed silica and its preparation method and application, comprising: step one, 20-200nm fumed silica nanoparticles are dispersed in ethanol / water mixed system, and sodium dodecyl benzene sulfonate is added to prevent agglomeration;Step two, under the catalysis of ammonia, tetraethyl orthosilicate and 1H, 1H, 2H, 2H-perfluorodecyltriethoxysilane are added dropwise in sequence for fluorination modification;Step three, fluorinated silica nanoparticle suspension is prepared by ultrasonic-assisted reaction;Step four, the solution is sprayed onto the surface of ceramic substrate with micro-nano structure to form a coating;Step five, strong adhesion without adhesive is realized by mechanical anchoring effect.The application realizes super-hydrophobic performance of 153±0.5° high water contact angle and physical adhesion stability under 100-200g load by the synergistic effect of nanoparticle size effect and substrate surface topological structure, low surface energy of fluorinated alkyl chain and Cassie-Baxter air cushion layer effect, and is especially suitable for self-cleaning surface, anti-icing coating and marine corrosion prevention field.

The application discloses a light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme, a preparation method and application, and belongs to the technical field of biomedical materials. In the application, spherical silica nanoparticles are used as a template, and a structure of copper ion-polydopamine coated silica nanoparticles is formed on the surface of the silica nanoparticles through self-polymerization of dopamine and chelation of copper ions, and the spherical structure is maintained with the support of the silica nanoparticles. The copper ion-polydopamine coated silica nanoparticles are pyrolyzed to obtain a copper-based single-atom nanoscale enzyme with a carbon skeleton, and a hollow spherical single-atom nanoscale enzyme is obtained after etching. Nitric oxide donor molecules are loaded into the hollow of the hollow spherical single-atom nanoscale enzyme to obtain the light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme. The application can realize the synergistic treatment effect of photothermal therapy, nitric oxide gas therapy and biological catalytic therapy, is used for efficiently removing bacteria and biofilms at an infected wound site, and effectively promotes the healing of the bacteria-infected wound.

The invention provides low-viscosity high-wear-resistance vehicle engine oil and a preparation method thereof, and belongs to the technical field of engine oil. According to the preparation method, an ionic liquid group is introduced through a reaction, a nano interlayer compound is constructed by combining surface modification of a metal-ionic liquid complex and silicon dioxide nanoparticles, and a microcapsule structure is formed through coating of a urea-formaldehyde prepolymer; the ionic liquid group provides a low friction coefficient and thermal stability, the silicon dioxide nanoparticles provide physical isolation and wear-resistant protection, and the microcapsules realize controlled release and dynamic repair of the lubricating components; a skeleton polymer is prepared through a reaction of polyamidoamine and epoxy chloropropane so as to provide abundant active sites, and oxidation resistance is improved through a synergistic effect of the skeleton polymer, hindered phenol and calixarene; by combining oleic acid modified nanoparticles, the dispersity and the wear resistance are enhanced, and meanwhile, dynamic protection is provided on a friction interface; the synergistic effect prolongs the service life of the engine oil and improves the high-temperature stability of the engine oil.

A composition including 85.00-99.00 wt. % of a single Nylon polymer; 0.25-5.00 wt. % of conductive nanomaterials; 0.25-5.00 wt. % of a dielectric filler comprising an inorganic, non-conductive, non-platelet nanomaterial selected from alumina nanoparticles, alumina nanotubes, aluminum oxide nanoparticles, silica nanoparticles, boron nitride nanoparticles, boron nanotubes, fumed silica, fumed alumina, and mixtures of one or more of these; and 0.25-5.00 wt. % of a dispersing agent.

The invention discloses a magnetic immobilized enzyme and a preparation method and application thereof in preparation of chitosan oligosaccharide, the immobilized enzyme comprises a carrier and an enzyme loaded on the carrier, the carrier is a magnetic nanoparticle modified double-hole silicon dioxide nanoparticle, the double-hole silicon dioxide nanoparticle simultaneously contains a plurality of macropores and a plurality of micropores, and the macropores and the micropores are uniformly distributed on the carrier. The aperture of the large hole is 20-40nm, the aperture of the small hole is 2-5nm, and the magnetic immobilized enzyme has strong magnetism, is more rapid and convenient to recover, has good reusability, is simple and convenient to operate, has a wide application prospect, and is suitable for industrial preparation of chitosan oligosaccharide.

The invention provides corona-resistant polyamide-imide insulating paint and a preparation method and application thereof, the polyamide-imide insulating paint is prepared from the following raw materials: aromatic tricarboxylic anhydride, aromatic diisocyanate and alcoholic hydroxyl group modified silicon dioxide nanoparticles, and the three materials are matched to prepare the corona-resistant polyamide-imide insulating paint. The obtained polyamide-imide insulating paint has excellent storage stability before curing, and after curing, silicon dioxide nanoparticles can be uniformly dispersed in a formed insulating paint film and are not easy to agglomerate; and therefore, the enameled wire prepared from the polyamide-imide insulating paint has excellent corona resistance and excellent flexibility, and is suitable for being applied to a high-voltage motor.

Methods and compositions including a CO2 foam treatment fluid having a plurality of functionalized silanol group silica nanoparticles the silanol group selected from the group consisting of an isolated silanol group, a vicinal silanol group, a geminaol silanol group, and any combination thereof; and a surfactant. The CO2 foam treatment fluids can be used for stimulation of subterranean formations for hydrocarbon production.

The invention relates to the field of molecular sieves, and discloses a modified and reinforced molecular sieve and application thereof in hydrocarbon dehydration, the modified and reinforced molecular sieve is obtained by mixing 4A molecular sieve raw powder, modified lamb liver soil and deionized water into spheres, calcining the spheres in a muffle furnace, crystallizing the spheres by using a sodium hydroxide solution, and then replacing the spheres by using a potassium chloride solution, the mass ratio of the 4A molecular sieve raw powder to the modified lamb liver soil to the deionized water is (5.5-6): 1: (1.2-1.6), the modified lamb liver soil is prepared by calcining lamb liver soil by using a muffle furnace and performing acid leaching for pretreatment, then performing amination modification by using gamma-aminopropyltriethoxysilane, and further performing in-situ growth of silicon dioxide nanoparticles on the surface of the aminated lamb liver soil through electrostatic assembly. The modified enhanced molecular sieve is prepared through balling, firing, crystallization in the alkaline environment and potassium chloride replacement, so that the static adsorption capacity of the modified enhanced molecular sieve is increased to about 24%, and the modified enhanced molecular sieve has better application in hydrocarbon dehydration.

The invention belongs to the technical field of hydrophobic surface materials, and particularly relates to a method for constructing a super-hydrophobic surface based on amphipathic hollow silicon dioxide Janus nanoparticles, which comprises the following steps: constructing amphipathic Janus particles by using an adhesion polypeptide sequence of an obtained membrane as an adhesion end and 1H, 1H, 2H, 2H-perfluorooctyltriethoxysilane as a hydrophobic end; a rapid and efficient surface super-hydrophobic coating is successfully constructed, and the surface is endowed with antibacterial and anti-protein adhesion effects.

The invention belongs to the technical field of biological medicines, and relates to a protein degradation system based on polyamide-amine dendrimers as well as a preparation method and application of the protein degradation system. The protein degradation system is of a nano-particle structure, and the nano-particle structure comprises silicon dioxide nano-particles and a polyamide-amine type dendritic polymer layer coating the surfaces of the silicon dioxide nano-particles. An MDM2 protein ligand, a GLUT1 protein ligand and an E3 ubiquitin enzyme ligand are connected to the polyamide-amine dendritic polymer layer through chemical bonds. The protein degradation system provided by the invention can be used for synergistically degrading the MDM2 protein and the GLUT1 protein. The synergistic degradation strategy not only can effectively inhibit proliferation and energy metabolism of tumor cells, but also can significantly enhance the stability of the p53 protein. By recovering the normal function of the p53 protein, the growth of tumor cells is further inhibited, and a new strategy is provided for tumor treatment.

The invention relates to the technical field of high polymer materials, in particular to a corrosion-resistant cable sheath material and a preparation method thereof. The sheath material is prepared by taking an ethylene-octylene copolymer as a matrix and compounding functional fillers such as an aminated magnesium ion exchange A type molecular sieve, dopamine shell silicon dioxide nanoparticles and phenylboronic acid / octadecyl double-grafted silicon dioxide nanoparticles. Wherein the aminated Mg-A molecular sieve is used for efficiently capturing and fixing chloride ions through an ion-dipole effect and a hydrogen bond network; the dopamine shell layer silicon dioxide enhances the interface bonding strength through dual active groups of catechol and amido; phenylboronic acid / octadecyl double-grafted silicon dioxide constructs a dynamic boric acid ester cross-linked network and a hydrophobic barrier, and synergistic protection of crack self-healing and moisture barrier is achieved. The sheath material remarkably improves the long-term corrosion resistance and mechanical stability of the cable in a severe environment.

A material composition to prepare a polymer electrolyte precursor composition capable to form a solid polymer electrolyte, which has: A) a comb-branched polymer with pendant functional groups; B)surface-modified silica particles; and C) a polymerizable solvent or a crosslinker; wherein the silica particles are capable to be dispersed in the polymerizable solvent or a non-polymerizable volatile organic solvent and form a colloidal silica dispersion can be made. The material composition can be used in preparation of a solid polymer electrolyte in a lithium ion battery to improve performance, a polymer electrolyte precursor composition, a preparation method of a solid polymer electrolyte, a method to prepare a lithium ion battery, a solid polymer electrolyte, an electrochemical device and a device.

An example of a resin composition includes an epoxy resin matrix and functionalized silica nanoparticles incorporated into the epoxy resin matrix. The functionalized silica nanoparticles have an average particle size up to about 10 nm. The resin composition is imprintable using nanoimprint lithography. The resin composition may be used to manufacture a patterned substrate for a flow cell.

The invention provides a preparation method of morphology-controllable silicon oxide nanoparticles, which comprises the following steps: (1) preparing alkali liquor which contains organic amine or amino acid with buffering capacity and has the pH value of about 8-10.5; (2) preparing hydrolysate which contains deionized water, ethanol and tetraethoxysilane in a certain proportion and has a controllable siloxane hydrolysis state; (3) adding the hydrolysate into the alkali liquor prepared in the step (1) according to a small-amount multi-time method, and reacting for 1-5 hours to obtain a silicon oxide nano-particle solution; and (4) carrying out large particle filtration, solvent replacement and concentration on the silicon oxide nanoparticle solution by an ultrafiltration method to finally obtain the silicon oxide nanoparticle product with controllable morphology. The morphology of the synthesized high-purity silicon oxide nanoparticles can be accurately regulated and controlled according to actual requirements. Due to the characteristic, the silicon oxide nano-particles can fully meet the diversified requirements on abrasive morphology under different chemical mechanical polishing (CMP) scenes.

The invention discloses a preparation method of a gel composite material for improving water resistance and heat preservation of waste textiles, which comprises the following steps: cleaning with hot water, adding a conventional detergent and a nonionic surfactant, boiling with an alkaline solution to remove grease and impurities, and disinfecting; carrying out refining treatment on the pretreated textile to form fibers; carrying out silane coupling agent modification treatment on the fibers; the fibers are coated with a low-heat-conductivity material coating formed by mixing silicon dioxide nanoparticles and a stabilizer, and trifluoroacetic acid is added as a cross-linking agent for cross-linking enhancement; preparing composite fibers through a wet spinning technology; and carrying out sol-gel conversion and supercritical drying treatment on the composite fiber obtained by wet spinning to finally obtain the waterproof and warm-keeping gel composite material. According to the method, the composite material is endowed with excellent heat-insulating property and waterproof property, and the overall stability and durability of the material are improved by enhancing the network structure of the coating and the structural stability of the composite fiber.

The invention discloses a surfactant for improving the recovery efficiency of an oil field, and relates to the technical field of oil field recovery. The cleaning agent is prepared from the following materials in parts: 10 to 500 parts of mahogany petroleum sulfonate, 20 to 450 parts of alkylbenzene sulfonate, 10 to 590 parts of fatty alcohol, 1 to 50 parts of ethylene oxide, 1 to 90 parts of silicon dioxide nanoparticles, 2 to 79 parts of alkyl halide, 20 to 90 parts of sodium hydroxide, 1 to 80 parts of sodium carbonate, 5 to 50 parts of xanthan gum, 1 to 78 parts of carbon nanotubes and 100 to 1000 parts of water. The invention further discloses a preparation method of the surfactant for improving the recovery efficiency of the oil field. Through the introduced material, the oil-water interfacial tension can be effectively reduced, crude oil can be more easily stripped from the rock surface, the oil displacement efficiency is remarkably improved, the oil displacement agent can be flexibly adjusted according to different oil reservoir conditions to adapt to a complex stratum environment, the oil displacement agent has good emulsifying performance, the crude oil can form a stable emulsion in water, and the fluidity of the crude oil is improved; the nanoparticles can form a stable interfacial film on an oil-water interface.

The present invention relates to an additive for all-solid-state rechargeable batteries, a solid electrolyte membrane, and an all-solid-state rechargeable battery, the additive comprising: porous silica nanoparticles; and a solid electrolyte reactive compound located inside the pores of the porous silica nanoparticles, wherein the solid electrolyte reactive compound has a melting point of 100ºC to 170ºC and includes a heteroatom-containing functional group.

The application discloses iron oxide coated silica core-shell nanoparticles and a preparation method and application thereof. The iron oxide coated silica core-shell nanoparticles comprise silica nanoparticles as an inner core and iron oxide nanoparticles as an outer shell coated on the inner core surface of the silica nanoparticles; the particle size is 22-112 nm; and the particle uniformity is 0.08-0.3. The preparation method of the iron coated silica nanoparticles provided by the application adopts the measure of adjusting the pH of slurry for multiple times, avoids the agglomeration of nanoparticles in a solution near the isoelectric point, and is thus favorable for finally obtaining core-shell nanoparticles with uniform monodispersity. No surfactant is used in the preparation process, and there is no complicated post-treatment process, thereby reducing the production cost. The uniformly monodispersed nanoparticles prepared by the method have great potential in the field of chemical mechanical polishing.