91results about How to "The synthesis method is simple" patented technology

The invention discloses a crystal compound, a preparation method thereof and application of the crystal compound in X-ray detection, imaging and anti-counterfeiting encryption, and belongs to the technical field of crystals. The molecular formula of the crystal compound is [Cu (totp) (CH3CN) 3] [Cu2I3 (totp) (PN)]. (CH3CN), wherein totp is tris (o-tolyl) phosphine; and PN is diphenyl-2-pyridine phosphine. The crystal compound disclosed by the invention is simple in preparation method, and has the characteristics of large mass attenuation coefficient of X-ray energy, high light yield and low detection limit when being used as a material of an X-ray detector. The compound also has the characteristic of structural transformation in solvents such as methanol, ethanol, acetone, dichloromethane, tetrahydrofuran and the like, and meanwhile, the conversion of luminescence color under the excitation of 365nm ultraviolet light and X rays is accompanied. The material can be applied to the aspects of scintillator materials, room-temperature X-ray radiation indirect detection materials, radiation detection dosimeters, X-ray scintillator medical imaging, anti-counterfeiting encryption and the like.

The invention relates to the technical field of biological medicines, and discloses hyaluronic acid modified metal coordination albumin nanoparticles as well as a preparation method and application thereof. The hyaluronic acid modified metal coordination albumin nanoparticle comprises a core and a hyaluronic acid shell layer, wherein the core is formed by self-assembly of an albumin-drug compound, poly-L-aspartic acid and ferric ions through coordination, and the hyaluronic acid shell layer is connected to the surface of the core through coordination or adsorption. According to the hyaluronic acid modified metal coordination albumin nanoparticles as well as the preparation method and the application thereof, the preparation method is simple, convenient and rapid, does not need complex covalent modification, is mild in condition and is easy for large-scale production, and the prepared nanoparticles are uniform in particle size, good in stability and high in stability. In addition, due to the fact that the hyaluronic acid is modified on the surface, the active targeting capacity on CD44 receptor high-expression tumor cells is achieved, the enrichment and treatment effects of the medicine on the tumor site are remarkably improved, and the application prospect in preparation of the anti-tumor medicine is wide.

The invention relates to the technical field of anion exchange membrane fuel cells, in particular to a cation remote grafting type polycarbazole anion exchange membrane and a preparation method thereof. The membrane is prepared by the following steps: condensing N-(4-bromobutyl) carbazole, N-alkyl carbazole and 2, 3-butanedione to obtain a polymer skeleton, then carrying out Menshutkin reaction on the polymer skeleton and cations to obtain polyelectrolyte, and finally carrying out ion exchange on the polyelectrolyte and sodium hydroxide. Wherein the main chain of the polymer has no unstable ether bond, so that the membrane has strong alkali resistance. The flexible overhanging side chain improves dimensional stability and increases polarity differences. Cations are grafted away from a framework, the alkali resistance of the membrane is improved, the service life is prolonged, hydrophilic / hydrophobic microphase separation is enhanced, an ion transmission channel is formed, and the ion conductivity is high. The membrane has good mechanical strength and flexibility, the tensile strength reaches 55.34 MPa, the elongation at break reaches 22.49%, the application requirements of fuel cells are met, and the membrane has excellent thermal stability and wide application prospects in alkaline anion exchange membrane fuel cells.

The application relates to a double-metal hydroxide, in particular to application of a CuAl double-metal hydroxide, in particular to application of the CuAl double-metal hydroxide in preparation of a preparation for inactivation of pathogenic bacteria, fungi and viruses. The CuAl double-metal hydroxide is prepared by a formamide liquid phase stripping method. Compared with the prior art, the application solves the problem of high cost of a silver ion loaded layered double-metal hydroxide in the prior art, and realizes preparation of a low-cost, high-performance and green antibacterial material with a bactericidal and antiviral effect.

The application provides a synthesis method of a polymerization inhibitor 706 by using a sulfonated silicon dioxide catalyst, and the synthesis method comprises the following steps: dissolving a polyoxypropylene polyoxyethylene copolymer solution in water, adding concentrated hydrochloric acid and heating to 40 DEG C, adding tetraethyl orthosilicate to the solution, adding 3-mercapto propyl trimethoxysilane and 30wt.% hydrogen peroxide after stirring, continuing to stir, and after the reaction is completed, filtering the solution to obtain a filter cake and a filtrate, mixing the filtrate with the filter cake after treating the filtrate with activated carbon, and obtaining the sulfonated silicon dioxide catalyst through aging, washing, acidification and drying; the sulfonated silicon dioxide catalyst synthesized by the method has the advantages of simple synthesis method, high catalytic reaction activity and high reaction selectivity in the synthesis of the 706 polymerization inhibitor.

This invention provides a naphthopyrimidine-fused-acid sugar derivative, its synthesis method, and its application, belonging to the field of pharmaceutical technology. The naphthopyrimidine-fused-acid sugar derivative has the structures shown in formulas (I) to (IV). These compounds are obtained by one-step cyclization via a condensation reaction with 1,8-diaminonaphthalene in an organic solvent under the catalysis of a trifluoromethanesulfonate catalyst, using a propionyl-protected and p-toluenesulfonated sugar as the starting material. The preparation method is efficient and simple. The compounds of this invention exhibit good anti-proliferative activity against colon cancer tumor cells.

The present application relates to a kind of tricyclic FXR antagonists and its preparation method, the structure of the tricyclic FXR antagonist is as shown in general formula I, the definition of each substituent group is as described in the specification and claims, compound as shown in general formula I can be used as FXR antagonist, can be used to prepare the drug for treating cholestasis, hyperlipidemia, diabetes and the like.

The invention belongs to the field of carbon-based electrode materials, and discloses a three-dimensional structure graphene material loaded with phosphorus-doped carbon nitride quantum dots as well as a preparation method and application of the three-dimensional structure graphene material. The three-dimensional structure graphene material is prepared through a simple hydrothermal reaction, phosphorus-doped carbon nitride quantum dots are uniformly dispersed on a graphene sheet layer, and nitrogen and phosphorus are successfully introduced into graphene through in-situ loading of the phosphorus-doped carbon nitride quantum dots. The graphene material with the three-dimensional structure integrally presents a good self-supporting three-dimensional skeleton structure, an electrode can be directly prepared under the condition that a conductive agent and a binder are not added, and the supercapacitor taking the graphene material with the three-dimensional structure loaded with the phosphorus-doped carbon nitride quantum dots as the electrode shows excellent electrochemical performance; wide application prospects are realized in the fields of electrode materials and energy storage devices.

The invention belongs to the field of preparation of photoelectric catalytic materials, and discloses a zirconium-based MOFs composite material loaded with carbon nitride quantum dots as well as a preparation method and application of the zirconium-based MOFs composite material. The composite material is prepared by adopting a solid phase method, and the method is simple, low in cost, easy to amplify, free of toxic solvents and environmentally friendly. The zirconium-based MOFs composite material loaded with the carbon nitride quantum dots prepared by the invention retains the advantages of large specific surface area and rich pore structure of the MOFs material, and shows excellent hydrogen production performance when the zirconium-based MOFs composite material loaded with the carbon nitride quantum dots is used as a photoelectrode material for hydrogen production by photoelectrocatalytic decomposition of water.

The invention discloses a method for leaching precious metal by using a colored TiO2 nanofiber photocatalyst, and belongs to the technical field of precious metal leaching and photocatalysis. The colored TiO2 nanofiber photocatalyst is prepared from TiO2 powder through solvothermal reaction, ion replacement and thermal reduction treatment, the responsiveness to visible light is remarkably enhanced, and the precious metal leaching reaction can be effectively carried out under the visible light. The precious metal leaching method can effectively reduce the energy consumption and the equipment cost in the photocatalytic leaching process of the precious metal, and has reference significance for practical industrial application of photocatalytic recovery of the precious metal.

The application provides a three-dimensional stacking undoped hole transport material, a preparation method and application thereof, and a perovskite solar cell, and belongs to the technical field of solar cells. The hole transport material has a core of an extended helical orthogonal structure, and a peripheral capping group controls planarity, reduces steric hindrance of the peripheral capping group, realizes 3D multidirectional 'network' dense stacking, and realizes a multidirectional continuous carrier transport channel. When the hole transport material is applied to a perovskite solar cell as a hole transport layer, a high open-circuit voltage of >1.1 V and a photoelectric conversion efficiency of >19% can be obtained without a dopant, a high-efficiency and stable undoped material system is realized, and the application prospect is wide.

The invention discloses a low-thermal-conductivity phase change aerogel material as well as a preparation method and application thereof. The phase change enthalpy value of the material is 50J / g to 110J / g; the phase change temperature is 0-60 DEG C; and the heat conductivity coefficient is 0.08 W / (m.K)-0.1 W / (m.K). The novel low-thermal-conductivity phase-change material is generated by curing polydimethylsiloxane (PDMS) and the phase-change microcapsules. The phase change aerogel material is simple in synthesis process, relatively high in phase change enthalpy value and good in phase change cycle stability. The method has important application prospects in the two aspects of heat energy collection and heat insulation temperature control.

The application discloses a pPAM long-circulating liposome, a preparation method and application thereof, and the long-circulating liposome takes a blank liposome as a carrier, internally carries a plasmid pPAM, and is decorated on the surface with a transferrin-penetratin complex Tf-Pen and an oxytocin receptor antibody OTR Ab； The plasmid pPAM carries a cDNA sequence of a peptide acylglycine alpha amidation monooxygenase PAM; and the blank liposome is composed of DSPC, PEG 2000 , cholesterol and lecithin. The application provides a new direction for development of endogenous polypeptide synthesis enzyme delivery technology and mental drugs, and improves the possibility of preparing new anti-anxiety and depression drugs, relieving mental stress and improving patient compliance.

The invention belongs to the technical field of electrochemical oxygen reduction, and relates to a preparation method and application of a high-dispersion mesoporous carbon sphere loaded nano platinum-cobalt intermetallic compound electrocatalytic oxygen reduction material, a high-dispersion mesoporous carbon sphere precursor is firstly prepared, then the high-dispersion mesoporous carbon sphere precursor is subjected to high-temperature carbonization treatment to obtain high-dispersion mesoporous carbon spheres, and the high-dispersion mesoporous carbon spheres are subjected to high-temperature carbonization treatment to obtain the high-dispersion mesoporous carbon sphere loaded nano platinum-cobalt intermetallic compound electrocatalytic oxygen reduction material. Then, mesoporous carbon spheres loaded with platinum-cobalt intermetallic compound precursors are prepared on the basis of the obtained high-dispersion mesoporous carbon spheres, finally, the mesoporous carbon spheres are subjected to high-temperature heat treatment, and finally the high-dispersion mesoporous carbon sphere loaded nano platinum-cobalt intermetallic compound electro-catalytic oxygen reduction material is prepared. According to the invention, the high specific surface area and regular pore structure of the mesoporous carbon spheres are utilized to realize high dispersion and confinement of the platinum-cobalt precursor, and intermetallic compound nanoparticles with uniform size and uniform distribution are formed through heat treatment. The obtained material has high precious metal utilization rate and excellent stability, the synthesis method is simple, operation is easy and convenient, repeatability is high, and large-scale production is easy to achieve.

The invention belongs to the field of agricultural science, and discloses a triazolyl isoindolinone compound I. The triazolyl isoindolinone compound I is obtained by using an isoindolinone skeleton as a basis and connecting an amino acid with a triazole ring containing a substituent group to construct an amide structure. The compound is simple in structure, mild in synthesis reaction condition, simple and convenient to operate and high in yield, has good bactericidal activity and can be used for developing agricultural bactericides.

The application belongs to the field of water pollution control, and discloses a preparation method and application of a flexible imprint MOFs catalyst capable of being magnetically recycled. A core-shell structure flexible imprint catalyst is synthesized by adopting a precipitation polymerization method with a magnetic Fe-MOF as a base. The catalyst has multi-target adsorption characteristics, can simultaneously and quickly target capture various sulfonamide organic matters in water, realizes efficient targeted degradation of sulfonamide organic pollutants in water, has the characteristics of magnetic recovery, can be quickly separated from the solution by an external magnetic field to realize efficient recovery and reuse of the catalyst, conforms to the green environmental protection concept, and has a good engineering application prospect.

This invention proposes a Zr-based membrane for separating benzene / cyclohexane and its preparation method. The Zr-based membrane includes Zr-BDC membranes, Zr-BDC-PAA, or Zr-BDC-PVA. A polymer is introduced into the Zr-BDC framework via a secondary growth method to improve the membrane's selectivity for separating benzene / cyclohexane. The Zr-based membrane is directly synthesized using an in-situ growth method, which is simple in process. By adjusting the membrane growth time, good benzene / cyclohexane separation performance is achieved. Zr-BDC-PAA or Zr-BDC-PVA membranes are organic-inorganic hybrid membranes. The addition of polymers can adjust the membrane's pore structure, enhance its polarity, improve the size selectivity for separating benzene / cyclohexane, promote the intercalation of the Zr-BDC membrane, and influence the membrane thickness to some extent. The Zr-BDC membrane, by adjusting the growth time, grows more densely and continuously, thus exhibiting good benzene / cyclohexane separation performance.

The application discloses a pyrrole ring-containing boron-sulfur doped fused ring aromatic hydrocarbon and a synthesis method and application thereof, and relates to a pyrrole ring-containing boron-sulfur doped fused ring aromatic hydrocarbon which is synthesized from simple raw materials such as 2,6-difluoronitrobenzene through a Clauson-Kaas pyrrole synthesis reaction and an electrophilic boronation reaction. Property research involves ultraviolet, fluorescence and CV tests, and mercury ion tests. The application has the characteristics of a short reaction path, a simple operation method and mild reaction conditions, and the compound has the potential of application in the field of photoelectric devices and can also be applied to mercury ion identification.

The application relates to a kind of SN38-fatty alcohol prodrugs and its self-assembly nanoparticles and application, belong to the field of new excipients and new dosage forms of pharmaceutical preparations, and relates to a kind of 7-ethyl-10-hydroxy camptothecin prodrug antitumor preparation, specifically to the construction of SN38-fatty alcohol prodrug and its self-assembly nanoparticles containing the prodrug, and its application as a drug delivery system in the preparation of antitumor drugs.The structure general formula (I) of SN38-fatty alcohol prodrug or its pharmaceutically acceptable salt is as follows: wherein, n, R, X are described in the claims and the specification.The SN38-fatty alcohol prodrug of the application can be self-assembled into nanoparticles, can effectively improve curative effect, reduce its toxic side effect.

The application discloses a lignin carbon-based halogen bismuth oxide Z-type heterojunction composite material with regular flower-like morphology and a preparation method and application thereof. A lignin carbon-based halogen bismuth oxide Z-type heterojunction composite material BiOX / C with regular flower-like morphology, wide spectral response range, high efficiency and strong stability is synthesized by using lignin carbon with rich oxygen-containing functional groups for induction and pH regulation. Based on the flower-like morphology structure and Z-type heterojunction of the material, the separation of photo-generated carriers and holes is effectively promoted, so that the material has higher photo-reaction efficiency, and the shortcomings of traditional photocatalytic degradation of organic pollutants, such as low quantum efficiency, slow degradation rate, poor stability, easy deactivation and the like, are effectively solved. Moreover, the lignin carbon-based substrate material takes lignocellulose in agricultural waste as a carbon source, is environment-friendly and low in production cost, and has the advantages of simple synthesis method, considerable yield, mild reaction condition in the process of photocatalytic degradation of organic pollutants, simple operation and wide application prospect.

The application belongs to the field of chemical materials, and particularly relates to a tributyl phosphonium modified ZIF-8 adsorbent and a preparation method and application thereof. The preparation method provided by the application comprises the following steps: synthesizing ZIF-8 metal organic framework particles, mixing the ZIF-8 metal organic framework particles with an organic solution of tributyl phosphonium and then heating, filtering, washing, drying and crushing to obtain the tributyl phosphonium modified ZIF-8 adsorbent. The preparation method provided by the application has few processes, low cost and mild conditions, can effectively realize the modification of tributyl phosphonium on ZIF-8, and the prepared adsorbent material can perform high-selectivity enrichment and recovery on high-value rare earth ions Dy 3+ in rare earth mine wastewater.

The application provides a high-brightness fluorescent dye for lipid droplet labeling and synthesis and application thereof, the fluorescent dye taking 1-acetyl pyrene as a parent body, and introducing a diphenylamine substituent group at 8, as shown in the following formula (1). The probe can specifically label lipid droplets in living cells, and has the advantages of high brightness, high signal-to-noise ratio, rapid labeling and the like. The lipid droplet dye has a very broad application prospect in dynamic imaging and real-time monitoring of lipid droplets.

The application discloses a fluorine-modified chitosan derivative used as a drug carrier, which has the following structure: a fluorine-containing compound is covalently connected to a chitosan main chain, the molecular weight of the chitosan ranges from 5000 to 5000000, and the fluorine-containing compound is a fluorine-containing aliphatic chain shown in the following formula (I) or an aromatic ring functional group shown in the following formula (II), wherein R1 is halogen (fluorine, chlorine, bromine or iodine), halogen-substituted alkane, cycloalkane, aldehyde group, carboxyl group, double bond, acetylene bond, hydroxyl group, sulfonyl chloride, sulfonic acid bond or sulfydryl, which are active groups capable of reacting with primary amino groups. The application aims to provide a novel drug carrier material with obvious drug absorption promotion effect and low toxicity, and the synthesis process of the fluorine-containing compound-modified chitosan is mature, simple to operate, high in synthesis efficiency, short in period, and capable of obtaining a high-yield drug carrier without complicated purification steps, so that the simple synthesis method provides a good foundation for commercialization.

The application provides a traditional fluorescent aromatic phosphorus material with a pyrene imidazole structure. The material can ensure effective energy transmission, realizes simultaneous transmission of hole and electron carriers, is beneficial to design of a device and improvement of performance, can be used for preparing an ultra-low voltage driven high-efficiency traditional blue-violet light emitting device, has good thermodynamic stability, and significantly improves luminous efficiency and brightness of an organic electroluminescent material.

This invention relates to a method for preparing a proton exchange membrane for water electrolysis and fuel cells, and its application, belonging to the technical field of proton exchange membrane materials. First, a main chain containing an arylpyridine polymer is prepared. Then, diamine-functionalized graphene oxide is introduced into the side chain. Next, cesium salts of heteropoly acids are doped during membrane fabrication. The main chain of the exchange membrane of this invention uses an arylpyridine polymer, which has excellent alkali resistance and a simple synthesis method and process. The side chain contains diamine-functionalized graphene oxide, and the doping of cesium salts of heteropoly acids within the membrane provides strong mechanical strength and proton conductor adsorption sites, effectively improving ionic conductivity and reducing acid loss during operation. The proton exchange membrane prepared by this invention is applied to high-temperature water electrolysis and medium-high temperature fuel cells.

The invention discloses a cage compound for specific recognition of lithium ions and a synthesis method of the cage compound, and belongs to the technical field of synthetic chemistry. The synthesis method comprises the following steps: (1) preparation: taking a tri-imidazolium salt compound, silver oxide and alkali metal carbonate as raw materials, mixing, and carrying out mechanical ball milling, so as to obtain the product; and (2) preparation: taking tetrahydrothiophene aurous chloride as a raw material, and reacting in a solvent in a dark place. The synthesis method has the advantages that synthesis is simple, raw materials are easy to obtain, the method is easy to operate, the reaction rate is high, the reaction condition is mild, the yield is high, the product singleness is good, the stability is good and the like, and the prepared cage-shaped compound has high selectivity and high stability in lithium ion recognition and is expected to be applied to lithium ion acceptors, sensors and the like.

The present application relates to a kind of enzyme immobilized chitosan emulsification material and its application in catalytic esterification reaction synthesis phytosterol acetate.The technical scheme used is: lipase is immobilized to chitosan surface by crosslinking agent to prepare the chitosan particle (CSPPL) of enzyme immobilized lipase, then the prepared CSPPL is used to prepare W / O Pickering emulsion catalytic system with phytosterol (PS), and the catalytic system can be used for the synthesis of phytosterol acetate, and each drop of emulsion is used as microreactor of reactant in oil phase.CSPPL can play the role of stabilizer, and also can play the role of catalyst;PS can play the role of stabilizer, and also as reaction substrate participates in catalytic reaction.Compared with homogeneous reaction, phytosterol / chitosan composite particle stable W / O Pickering emulsion catalytic system has good conversion rate.

Alcohols as a class of abundant, diverse and easily accessible basic chemicals, widely exist in various drug molecules, agrochemicals, natural products. Fluoroolefins exhibit wide application value in medicinal chemistry and synthetic chemistry, can precisely regulate the molecular spatial conformation, reactivity and stability, thereby improving the biological activity and reaction selectivity of compounds, and providing an important way for drug structure optimization and synthetic method innovation. The present application takes fluoropropenoic acid and alcohol derivatives as reaction substrates, realizes the efficient method of deoxidation of alcohol compounds to synthesize fluoroolefins under mild conditions. The method has the advantages of mild reaction condition, high product selectivity, simple operation and easy to obtain raw materials. It provides an efficient and convenient synthesis method for deoxidation of alcohol compounds to synthesize fluoroolefin compounds.

The invention discloses a near-infrared fluorescent probe with an aggregation-induced emission enhancement effect. The near-infrared fluorescent probe is used for dual detection of hydrogen sulfide and hydrazine. The fluorescent probe is synthesized by carrying out Knoevenagel condensation reaction on 4-hydroxy-3-(1, 4, 5-triphenyl-1H-imidazolyl) benzaldehyde (I) and 2-(2-methyl-4H-chromene-4-subunit) malononitrile (II) under the catalytic action of piperidine, and the chemical structural formula of the fluorescent probe is as shown in the formula (III). The fluorescent probe shows high selectivity and high sensitivity to both hydrogen sulfide and hydrazine, the detection limits are as low as 50.1 nM and 89.2 nM respectively, and the fluorescent probe can be used for various scenes such as food spoilage monitoring and environmental water sample detection, can be used for biological imaging, and shows important application potential in the aspect of detection of hydrazine and hydrogen sulfide in organisms.

This invention belongs to the field of polymer materials technology, specifically to active cationic polymerization coupling agents, their preparation methods, and applications. The coupling agent of this invention is 1,2-bis[4-[1-(4-methoxyphenyl)vinyl]phenyl]ethane, denoted as bis-DPE-OMe; specifically, 1,2-bis(4-acetylphenyl)ethane is synthesized from 1,2-bisphenylethane via a Friedel-Crafts acylation reaction; then, 1,2-bis[4-[1-hydroxy-1-(4-methoxyphenyl)-1-ethyl]phenyl]ethane is synthesized via a Grignard reaction; finally, the target product is obtained through intramolecular dehydration. This coupling agent can be used to couple active chain ends to obtain homopolymers and block copolymers, including for the coupling of polyisobutylene and poly(isobutylene- b Poly(styrene-) diblock copolymers were coupled to prepare poly(styrene-) b -Isobutylene- b (-Styrene). Compared with existing technologies, this invention synthesizes a novel and highly efficient cationic polymerization coupling agent. The synthesis process of the coupling agent is simple and it is easy to achieve coupling to the ends of the active PIB chains.