219 results about "Reaction intermediate" patented technology

The invention discloses a compound containing a urea structure as well as a preparation method and application of the compound in a color developing agent, and relates to the technical field of color developing agents. The compound containing the urea structure is a # imgabs0 # structure as shown in a formula 1. The compound containing the urea structure is synthesized through multiple steps of Suzuki reaction, bromination reaction and substitution reaction. The compound is used as an electron donor to be applied to a thermosensitive color development system and forms a color development composition with a phenolic compound and an acidic material, and the activation temperature is as low as 60-120 DEG C. The ureido structure stabilizes a reaction intermediate through a hydrogen bond network, enhances the electron transfer efficiency, and significantly improves the color developing sensitivity; the aryl / heteroaryl substituent optimizes the color contrast through the conjugation effect, and meanwhile, the synergistic effect of the hot-melt filler ensures the stability of the system. Compared with a traditional color developing agent, the color developing agent has the advantages of low-temperature activation, high color developing intensity and excellent weather resistance, is suitable for the fields of thermal printing, anti-counterfeiting materials and the like, and overcomes the defects of high reaction temperature and insufficient stability in the prior art.

The invention discloses a Pt-loaded hierarchical pore HY molecular sieve double-effect catalyst and a preparation method and application thereof.The preparation method comprises the steps that firstly, an acid solution and an HY molecular sieve are mixed, heated and stirred, and the hierarchical pore HY molecular sieve is obtained; then, Pt salt is loaded on the hierarchical pore HY molecular sieve through an impregnation method, and the hierarchical pore HY molecular sieve is dried, calcined and then reduced. The concentration of the acid solution is not higher than 0.1 mol / L; the catalyst is used for hydrocracking of polyethylene or polypropylene. According to the Pt-loaded hierarchical pore HY molecular sieve double-effect catalyst disclosed by the invention, Pt atoms have excellent C-H bond activation capability, meanwhile, the hierarchical pore HY molecular sieve carrier has an open connection mesoporous structure and an acid site, and the mesoporous structure constructed by acid pickling and dealumination is beneficial to diffusion of a reaction intermediate and improvement of the yield of a liquid product; more orifice acid can be exposed by surface erosion, so that the initial cracking of reaction raw materials is facilitated, and the catalytic performance is improved.

The invention provides a hydrogen fuel cell catalyst as well as a preparation method and application thereof, and relates to the technical field of catalysts, the catalyst comprises an N atom modified carbon carrier and platinum alloy nanoparticles loaded on the surface of the carbon carrier, the platinum alloy nanoparticles are binary or multicomponent alloys formed by Pt and metal M, the molar ratio of platinum to the metal M is (0-10): 1, and the molar ratio of platinum to metal M is (0-10): 1. The weight ratio of the N atom modified carbon carrier to the platinum alloy nanoparticles is (25-80): (75-20). According to the preparation method of the hydrogen fuel cell catalyst, the N-modified carbon-supported PtFe alloy is prepared by a two-step pyrolysis method, so that the use amount of Pt is effectively reduced, the cost is controlled, and the utilization rate of Pt is increased; through the strong coordination capability of the 1, 10-phenanthroline, the formed Fe-N-C layer can restrain the growth and agglomeration of the PtFe alloy nanoparticles, the adsorption to a reaction intermediate is weakened, and the oxygen reduction activity and stability of the alloy catalyst are improved.

The present application provides a kind of for the preparation of C 3+ The application discloses a catalyst for olefin, a preparation method and application, the catalyst is supported by a molecular sieve, and the molecular sieve is MFI molecular sieve or SBA-16 molecular sieve, and the catalyst is loaded with multi-metal, and the multi-metal includes metal tungsten, transition metal and alkali metal. The catalyst is used for providing Lewis acid sites by introducing metal tungsten into MFI molecular sieve or SBA-16 molecular sieve by one-step process, and further selectively introducing transition metal and alkali metal. By selectively coupling hydrogenation-dehydrogenation sites, C-C coupling sites and alkali metal sites in the same multifunctional catalyst, the synergies between the molecular sieve carrier and the multi-metal are realized. The catalyst realizes high-efficiency ethanol-to-C 3+ Olefins conversion in ethanol, with acetaldehyde as the reaction intermediate, and has the advantages of high C 5+ Olefins selectivity.

The invention relates to the technical field of intermetallic compound catalysts, and particularly discloses a preparation method of a hexagonal layered Pt-Bi intermetallic compound nanocrystalline catalyst, which comprises the following steps: weighing octadecene and oleylamine, and mixing to obtain a solution A; platinum acetylacetonate, bismuth acetate, ascorbic acid and hexadecyl trimethyl ammonium bromide are weighed and sequentially poured into the solution A, and a solution B is obtained through mixing and ultrasonic treatment; heating and preserving heat of the solution B, and naturally cooling to room temperature to obtain a turbid liquid C; and measuring cyclohexane and ethanol, sequentially pouring into the turbid liquid C, carrying out ultrasonic treatment at room temperature for 3 minutes, then pouring out supernate, repeating for 2-3 times, collecting a product, and drying to obtain the nanocrystalline catalyst. According to the invention, the electron interaction between bimetallic components is utilized, the electron structure of a catalytic active center is optimized, the interaction between the active structure and reaction active species is enhanced, the evolution kinetics of a plurality of reaction intermediates such as * O and * OOH in the electrocatalytic oxygen reduction reaction can be obviously accelerated, and the kinetics rate of the four-electron oxygen reduction reaction is improved.

The invention discloses a liquid metal-based catalyst with flowable amorphous cobalt active sites as well as a preparation method and application of the liquid metal-based catalyst. The spherical gallium-based liquid metal loaded amorphous cobalt nanosheet material is synthesized by using a sodium borohydride ice bath method. Due to the optimization of the synthesis process, the amorphous cobalt nanosheets are uniformly distributed on the surfaces of the liquid gallium balls, are small in size, are high in utilization rate and are not easy to agglomerate; the intrinsic flow characteristic of the liquid metal gallium realizes the efficient reverse hydrogen overflow effect, optimizes the formation process of a catalytic reaction intermediate, and accelerates the formation of the intermediate. The composite material has the advantages of low overpotential, high Faraday efficiency, high ammonia production rate, good stability and the like during nitrate electrocatalytic reduction reaction, meets the requirements of production and use, and is low in preparation cost.

The invention belongs to the technical field of catalysts, and particularly relates to application of a non-noble metal supported catalyst in catalytic hydrogenation reaction and a method for catalyzing 5-methyl-3-hexene-2-ketone hydrogenation by using the non-noble metal supported catalyst to obtain methyl isopentanone. The invention provides application of a non-noble metal supported catalyst in catalytic hydrogenation reaction. The non-noble metal supported catalyst comprises a composite carrier and an active component supported in the composite carrier, the composite carrier is aluminum oxide and lanthanum oxide, and the active component comprises iron, cobalt, copper or nickel. The non-noble metal supported catalyst provided by the invention can provide catalytic active site density and electron transfer efficiency which are equivalent to or even better than those of a noble metal catalyst under interaction of an active center structure, electronic characteristics and a carrier; meanwhile, the unique d electron orbital characteristic is beneficial to stabilization of a reaction intermediate and reduction of transition state activation energy, so that the catalyst cost is remarkably reduced while the selectivity of catalytic hydrogenation is remarkably improved.

According to the catalyst for generating ethylene through electrocatalytic reduction of carbon dioxide, a CuO / SrCO3 heterojunction is synthesized through high-temperature liquid-phase pyrolysis and carbonization, an energy barrier of a reaction intermediate can be optimized through the electron effect of a heterojunction interface carried by the catalyst, efficient adsorption of OCHCHgroups of the reaction intermediate is achieved, and the catalytic activity of ethylene is improved. Further proton coupling of the intermediate is promoted, and finally, a target reduction product C2H4 is efficiently generated; meanwhile, the stability of the structure is guaranteed by a stable heterojunction surface of the heterojunction, so that the heterojunction has excellent durability.

The invention relates to the technical field of preparation of electro-catalysis electrode materials, in particular to a preparation method and application of a SeO2 doped RuO2 electrolyzed water catalyst.The preparation method comprises the steps that S1, ruthenium acetate and selenium dioxide are dissolved in deionized water together and continuously stirred to obtain a mixed solution A, then sodium citrate is dissolved in deionized water, and the PH value is adjusted to be 9 with ammonia water to obtain a solution B; s2, mixing the solution A and the solution B, reacting at 80 DEG C for 12 hours, naturally cooling, ultrasonically washing with deionized water and ethanol in sequence, centrifuging, and drying in a drying oven to obtain a catalyst precursor; and S3, carrying out two-step pyrolysis on the precursor, namely heating to 250 DEG C, annealing for 4 hours, heating to 400 DEG C, annealing and heating for 2 hours, so as to obtain the SeO2-doped RuO2 nanosheet. By introducing a proper amount of SeO2 for doping, the electronic structure of RuO2 is optimized, the adsorption and desorption balance effect of the catalyst on a reaction intermediate is adjusted, the Ru site catalytic performance is improved, and the obtained SeO2-doped RuO2 nanosheet has efficient acidic OER catalytic performance.

The invention discloses a dynamic behavior analysis method and system for kiln high-temperature synthesis, and relates to the technical field of high-temperature material synthesis monitoring, and the method comprises the steps: obtaining time sequence data through a high-frequency temperature sensor, a reaction intermediate detector and a flue gas component monitor, and carrying out the feature extraction; the micro-scale adopts molecular dynamics simulation to obtain local reaction dynamic behaviors, and the macro-scale simulates kiln temperature distribution based on a finite element method; fusing the feedback relationship between the local reaction rate and the temperature distribution by using multi-scale coupling; dividing the high-temperature synthesis process of the kiln into a plurality of continuous recognizable states, judging whether a state jump condition is met or not, and performing multi-objective optimization iteration to obtain a dynamic behavior analysis result and phase change stage judgment. According to the method, dynamic feedback of the reaction rate and the temperature field is realized, key inflection points and phase change characteristics can be accurately captured, the fitting precision of kinetic parameters is remarkably improved, and the robustness and the adaptive capacity of the model are enhanced.

The invention discloses a copper-cobalt alloy / lanthanum hydroxide heterojunction catalyst and a preparation method and application thereof.The preparation method includes the steps that lanthanum-based perovskite oxide LaCu (1-x) CoxO3 is prepared through a sol-gel method, and x is equal to 0.1-0.5; laCu1-xCoxO3 is placed in hydrogen and argon mixed gas for reduction treatment, and the copper-cobalt alloy / lanthanum hydroxide heterojunction catalyst is obtained and used for preparing ammonia through electro-catalysis nitrate radical reduction. According to the preparation method, an in-situ dissolution strategy is adopted, a copper-cobalt alloy / lanthanum hydroxide strong interface coupled heterostructure is constructed, CuCo alloy nanoparticles provide high conductivity and rich active sites and form a heterostructure with La (OH) 3, the d-band center of the active sites is optimized through interaction of strong electrons, NO3 <-> adsorption and reaction intermediate stability are promoted, and the stability of the reaction intermediate is improved. The excellent electro-catalytic performance is realized.

The invention discloses a La and Ca double-doped Co3O4 electrocatalyst and a preparation method and application thereof, and relates to the technical field of electrolyzed water catalysts.The preparation method comprises the steps that a Pt coating titanium mesh (PTL) serves as a substrate and a working electrode, and a Co-LaCa film is deposited on the surface of the substrate and the working electrode by using a self-made target material through a magnetron sputtering method; and washing, drying and calcining the obtained PTL sheet to obtain the catalyst. According to the invention, Ca and La are doped on the surface of Co3O4 to construct a hydrophilic-hydrophobic coupling structure, so that the acidic OER stability is remarkably improved. Ca is introduced to generate high-activity unsaturated Co sites, so that activity and stability are balanced, interface water interaction is promoted, formation and conversion of reaction intermediates are accelerated, the water / catalyst interface microenvironment is optimized at the atomic level, and a new way is provided for improving catalytic stability.

This invention discloses a supported zirconium-based catalyst, its preparation method, and its application. It includes a zirconium-based support and a noble metal supported on the zirconium-based support. The zirconium-based support includes one or more of a zirconium-based composite oxide support and a zirconium-based metal-organic framework material. The zirconium-based composite oxide support includes a composite of zirconium oxide and other oxides, and the other oxides include oxides of one or more elements selected from Si, P, Ce, and Mg. The above-mentioned supported zirconium-based catalyst increases the interaction between the supported noble metal and the support by introducing Si, P, Ce, or Mg into the zirconium-based support to adjust the electron cloud density or oxygen vacancy concentration of the zirconium-based support. By using a zirconium-based metal-organic framework material with regular channels to support the noble metal, reactants and products can diffuse relatively quickly and smoothly, thereby avoiding excessive side reactions and carbon deposition caused by excessive retention of reaction intermediates or products.

The invention discloses a medium-entropy catalyst based on a self-reduction strategy as well as a preparation method and application of the medium-entropy catalyst, and belongs to the technical field of catalysts. The preparation method of the medium-entropy catalyst based on the self-reduction strategy comprises the following steps: jointly dissolving a non-Cu metal salt of which the metal activity is weaker than that of iron, a Cu salt, a metal coordination agent and a surfactant into water to prepare a plating solution, and immersing foam iron serving as a substrate into the plating solution for 10-60 minutes for entropy increase to obtain the medium-entropy catalyst, the molar ratio of Cu to non-Cu metal in the plating solution is (1-2): (1-4). The adsorption / desorption behavior of a reaction intermediate is optimized by cooperatively regulating an electronic structure through multiple elements, and the method has important significance for improving the performance of the NO3RR.

The invention discloses a heterogeneous electrocatalyst with a spine array structure and a preparation method and application of the heterogeneous electrocatalyst, and relates to the technical field of industrial wastewater treatment and purification catalysts, the heterogeneous electrocatalyst comprises a cuprous oxide nanorod substrate, the surface of a cuprous oxide nanorod is provided with nano spine array morphology which is evenly distributed, and the nano spine array morphology is in the shape of a cuprous oxide nanorod. The component of the nanometer spine array morphology is precious metal-copper / cuprous oxide. According to the invention, active sites are exposed to the maximum extent through a spine array structure, nitrate adsorption and electron transmission efficiency are enhanced, and through interface regulation and control of multiple metal components, adsorption energy of a reaction intermediate is optimized, hydrogen evolution competitive reaction is inhibited, and hydrogen evolution efficiency is improved. Therefore, the problems of insufficient exposure of active sites and low mass transfer efficiency of the existing electrochemical nitrate reduction heterostructure catalyst are solved.

The application provides a regeneration method of halogenated nitrobenzene continuous hydrogenation catalyst, and relates to the technical field of fixed bed halogenated nitrobenzene hydrogenation. The regeneration method mainly comprises the following steps: using alcohol, alkali, petroleum ether and ethyl acetate to preliminarily clean the bed layer, removing azo compounds and other pollutants on the surface of the catalyst by using the special properties of ionic liquids, and then completing the regeneration of the catalyst through the steps of pickling, precious metal solution treatment and drying. The application overcomes the defects of the prior art, has the advantages of simple operation, mild conditions and low cost, realizes the in-situ removal of surface impurities such as reaction intermediates and azo compounds on the catalyst surface without damaging the structure of the catalyst and disassembling the catalyst, further supplements the lost metal active components, and can effectively restore the catalyst activity.

The present invention discloses a compound containing a urea structure, a preparation method thereof, and an application in a developer, which relates to the technical field of developers. The compound containing a urea structure has the structure shown in Formula 1. The compound containing a urea structure is synthesized through multiple steps including a Suzuki reaction, a bromination reaction, and a substitution reaction. This compound is used as an electron donor in a thermosensitive color development system and forms a color development composition with phenolic compounds and acidic substances, and the activation temperature is as low as 60 - 120 °C. Its urea group structure stabilizes the reaction intermediate through a hydrogen bond network, enhances the electron transfer efficiency, and significantly improves the color development sensitivity; the aryl / heteroaryl substituents optimize the color development contrast through a conjugation effect, and at the same time, the hot-melt filler synergistically ensures the stability of the system. Compared with traditional developers, the present invention has both low-temperature activation, high color development intensity, and excellent weather resistance, and is suitable for fields such as thermosensitive printing and anti-counterfeiting materials, solving the defects of high reaction temperature and insufficient stability in the prior art.

The invention relates to a preparation method and application of a copper-nickel double-atom modified MXene-based electrocatalyst. According to the method, CuNiDA / MXene is obtained through acid leaching of CuNi / MXene with hydrochloric acid, copper-nickel diatoms with low metal loading capacity are obtained, and residual copper-nickel alloy nanoparticles in the molten salt etching process are successfully converted into the copper-nickel diatoms to be loaded on an MXene substrate in situ; the obtained copper-nickel diatom modified MXene-based electrocatalyst has copper-nickel diatoms coordinated by oxygen functional groups, so that the adsorption of reaction intermediates is enhanced, and the electrocatalytic performance is further improved. The prepared electrocatalyst shows the ammonia yield as high as 59225 [mu] g h <-1 > mg CuNi atom <-1 > and the Faraday efficiency as high as 94.8% in a reaction system for reducing nitrite into ammonia, and has the industrial prospect of green and sustainable synthesis of ammonia.

The invention discloses a preparation method of a Schottky composite material, a coating, an antibacterial stent and application, and belongs to the field of biological materials. According to the preparation method, Pdene of a two-dimensional structure is prepared through a wet chemical reduction method, then bismuth oxychloride (BiOCl) nanoflowers are grown on metal alkene (Pdene) in situ through an electrostatic adsorption mode, the obtained schottky composite material can regulate and control interface charge redistribution, the adsorption energy of reaction intermediate products is optimized, meanwhile, the piezoelectric property of BiOCl is enhanced, and the performance of the schottky composite material is improved. Bacterial oxidative stress can be effectively promoted, bacterial energy metabolism is interfered, finally, efficient removal of bacteria is achieved, and hard tissue repair is promoted.

The invention relates to an asymmetric iridium monatomic nano enzyme Ir-S / N-C and a preparation method thereof. S atoms are introduced, an active center with an Ir-S1N3 asymmetric coordination structure is constructed, the electronic structure of the iridium active center is effectively changed, the center position of a d band of the iridium active center is moved upwards, the adsorption / desorption behavior of a reaction intermediate is optimized, a reaction energy barrier is remarkably reduced, and the reaction efficiency is improved. The activity of the oxidoid enzyme reaches 27.98 U / mg, and the activity of the peroxidase reaches 330.24 U / mg; the invention further relates to application of the asymmetric iridium monatomic nano enzyme Ir-S / N-C in preparation of a product for detecting cholinesterase. According to the detection strategy, unstable H2O2 does not need to be additionally added, the operation steps are simplified, the stability and anti-jamming capability of a system are improved, and false positive signals are effectively reduced. Experiments prove that the constructed detection method has a good linear relation and high sensitivity on detection of cholinesterase, the detection limit is as low as 0.21 U.L <-1 >, and great application potential in the fields of biomedical diagnosis and environmental monitoring is shown.

The invention provides a method and equipment for screening an electrochemical alloy oxide catalyst. Comprising the following steps: utilizing a trained machine learning model to predict the difference of second adsorption free energy of each predicted active site on the surface of an alloy oxide to be detected to an electrochemical reaction intermediate; obtaining the first average current density and the uncertainty of the current density based on the difference of the second adsorption free energy of each predicted active site; determining a pre-selected alloy oxide by using the acquisition function to obtain a second average current density of the pre-selected alloy oxide; and under the condition that the difference value between the second average current density and the obtained maximum value of the first average current density is smaller than a preset value, determining that the pre-selected alloy oxide is the target alloy oxide catalyst for the electrochemical reaction. In this way, the electrochemical alloy oxide catalyst with high electrochemical catalytic activity can be rapidly screened out.

A pseudo-boehmite has a ratio of crystalline sizes D(130) and D(020) at a ratio of D(130) / D(020)=1.0-1.5, preferably, 1.1-1.3. A preparation method of the pseudo-boehmite, a catalytic cracking catalyst containing the pseudo-boehmite, and a preparation method and application of the catalytic cracking catalyst are provided. The pseudo-boehmite is applied to a catalytic cracking catalyst, and can produce a significant mesopore distribution in case that the catalyst strength is qualified, significantly improving the pore structure of the catalyst, which is of great significance for promoting the efficient diffusion of heavy oil macromolecules, reaction intermediates and product molecules in the catalyst, reducing the coke yield, and optimizing the product distribution.

The present invention provides a process route for producing auristatin derivative intermediates, which effectively avoids the use of norephedrine in the synthesis route compared to the prior art. Furthermore, the process route for auristatin derivative intermediates according to the present invention allows for the production of the target product in a single step, effectively avoids the generation of reaction intermediates, has a simple purification method, and produces a high yield and purity of the final product, making it suitable for industrial-scale scaling up.

The invention provides a compound for an oil-based drilling fluid viscosity reducer and the oil-based drilling fluid viscosity reducer. The preparation method of the compound for the oil-based drilling fluid viscosity reducer comprises the following steps: mixing polyethylene polyamine, alcohol amine and humic acid for reaction to obtain a first reaction intermediate; and reacting the first reaction intermediate with a fluorine-containing silane coupling agent to obtain the compound for the oil-based drilling fluid viscosity reducer, wherein the ratio of the amount of substance of the humic acid to the polyethylene polyamine to the alcohol amine to the fluorine-containing silane coupling agent is 1 to (0.5 to 0.75) to (0.01 to 0.5) to (0.5 to 5). The viscosity reducer for the oil-based drilling fluid comprises the compound for the viscosity reducer for the oil-based drilling fluid, a fluorine-containing surfactant and an oil-phase solvent in a mass ratio of 100: (10-50): (20-80). The oil-based drilling fluid viscosity reducer provided by the invention has excellent high temperature resistance.

The invention provides a catalyst for preparing C3 + olefin from ethanol through a one-step method, a preparation method and application, the catalyst takes a molecular sieve as a carrier, multiple metals are loaded on the carrier, the molecular sieve is an MFI molecular sieve or an SBA-16 molecular sieve, and the multiple metals comprise metal tungsten, transition metal and alkali metal. The method comprises the following steps: introducing metal tungsten into an MFI molecular sieve or an SBA-16 molecular sieve by adopting a one-step process to provide a Lewis acid site; and transition metal and alkali metal are further selectively introduced. A hydrogenation dehydrogenation site, a C-C coupling site and an alkali metal site are selectively coupled in the same multifunctional catalyst, so that the synergistic effect between the molecular sieve carrier and multiple metals is realized. According to the catalyst, acetaldehyde is used as a reaction intermediate in ethanol conversion, efficient reaction for preparing C3 + olefin from ethanol is realized, and meanwhile, the catalyst has the advantage of high C5 + olefin selectivity.

The application discloses a kind of graphene nanometer heavy anticorrosive coating and preparation method thereof, belong to anticorrosive coating technical field.The coating includes the following mass parts of components: diallyl bisphenol A type epoxy resin 50-70 parts, histidine modifier 8-15 parts, graphene nanometer composite modified filler 12-20 parts, curing agent 5-10 parts, leveling agent 0.5-2 parts, defoaming agent 0.3-1 part.Histidine modifier is generated by 1-palmitoyl-2-oleoyl ethanolamine and N-formyl-L-histidine through Schiff base reaction intermediate A;Again with spiro ring quaternary ammonium reagent reaction forms quaternary ammonium salt intermediate B;Again with aminopropyl triethoxysilane and silicotungstate composite is obtained.Graphene nanometer composite modified filler is formed by graphene oxide / bentonite intercalation structure, by allyl trimethoxysilane surface modification.The graphene nanometer heavy anticorrosive coating prepared by the application forms high dense crosslinking network, has excellent barrier property, strong adhesion, impact resistance and long-acting anticorrosion performance.

The invention discloses a preparation method and application of a cerium-doped CoTeO3 nano-cluster catalyst, and belongs to the technical field of chemical energy materials. The preparation process comprises the following steps: firstly preparing a metal salt solution and a NaHTe solution, dropwise adding the NaHTe solution into the metal salt solution, stirring, centrifuging, cleaning and drying to obtain the cerium-doped CoTeO3 nano-cluster catalyst. The cerium-doped CoTeO3 nano-cluster catalyst prepared by the invention is constructed by a chemical reduction method, the conductivity of the catalyst is remarkably enhanced by introducing transition metal telluride, and the electronic structure of active sites is further optimized by doping rare earth cerium. In an electrocatalytic oxygen evolution reaction (OER), the catalyst breaks through the energy barrier limitation of a catalytic reaction intermediate by introducing a lattice oxygen oxidation mechanism (LOM), shows excellent catalytic activity and stability, and shows a good industrial application prospect.

Provided is a method for producing an olaparib precursor, said method comprising the step of performing the following steps (a) to (c) continuously without isolating a reaction intermediate. (a) Reacting dimethyl(3-oxo-1,3-dihydro-2-benzofuran-1-yl)phosphonate and 2-fluoro-5-formylbenzoic acid in DMF, acetonitrile, or THF and in the presence of diazabicycloundecene. (b) Reacting the reaction mixture obtained in the reaction of (a) with hydrazine. (c) Adjusting the reaction liquid obtained in the reaction of (b) to a pH of not more than 4, to obtain 2-fluoro-5-(4-oxo-3,4-dihydro-phthalazine-1-ylmethyl)-benzoic acid, which is an olaparib precursor.

Compared with the prior art, the process route for preparing the intermediate of the aurestatin derivative has the advantages that the use of norephedrine in a synthesis route is effectively avoided, in addition, the target product can be produced in one step by the process route of the intermediate of the aurestatin derivative, and the process route is suitable for industrial production. The method can effectively avoid generation of reaction intermediate products, the purification method is simple, the yield and purity of the final product are high, and the method is suitable for industrial expanded production.