24 results about "Reaction intermediate" patented technology

This invention discloses a supported zirconium-based catalyst, its preparation method, and its application. It includes a zirconium-based support and a noble metal supported on the zirconium-based support. The zirconium-based support includes one or more of a zirconium-based composite oxide support and a zirconium-based metal-organic framework material. The zirconium-based composite oxide support includes a composite of zirconium oxide and other oxides, and the other oxides include oxides of one or more elements selected from Si, P, Ce, and Mg. The above-mentioned supported zirconium-based catalyst increases the interaction between the supported noble metal and the support by introducing Si, P, Ce, or Mg into the zirconium-based support to adjust the electron cloud density or oxygen vacancy concentration of the zirconium-based support. By using a zirconium-based metal-organic framework material with regular channels to support the noble metal, reactants and products can diffuse relatively quickly and smoothly, thereby avoiding excessive side reactions and carbon deposition caused by excessive retention of reaction intermediates or products.

The application provides a regeneration method of halogenated nitrobenzene continuous hydrogenation catalyst, and relates to the technical field of fixed bed halogenated nitrobenzene hydrogenation. The regeneration method mainly comprises the following steps: using alcohol, alkali, petroleum ether and ethyl acetate to preliminarily clean the bed layer, removing azo compounds and other pollutants on the surface of the catalyst by using the special properties of ionic liquids, and then completing the regeneration of the catalyst through the steps of pickling, precious metal solution treatment and drying. The application overcomes the defects of the prior art, has the advantages of simple operation, mild conditions and low cost, realizes the in-situ removal of surface impurities such as reaction intermediates and azo compounds on the catalyst surface without damaging the structure of the catalyst and disassembling the catalyst, further supplements the lost metal active components, and can effectively restore the catalyst activity.

The application belongs to the technical field of catalytic chemistry and porous materials, and specifically discloses a kind of vacancy anchoring full-silicon core-shell monatomic catalyst and its preparation method, the application makes Fe highly dispersed in the form of monatomic through the synergistic anchoring effect of silicon vacancy and ligand, avoids the metal oxide cluster produced by traditional impregnation method, inhibits excessive pyrolysis caused by local overheating, reduces the generation of gas impurities such as low-carbon alkane, the crystalline shell layer of the catalyst shortens the diffusion path of the product dimethyl ethylene ketone, DMK molecules can be quickly desorbed and leave the active center after generation, the content of by-product dimers is reduced, the structure of the catalyst improves the feed rate and accelerates the product diffusion, prevents the secondary reaction of reaction intermediates in the pore, greatly reduces the carbon deposition rate, forms a hydrophobic gradient layer by MTES modification, effectively repels the associated by-products isobutyric acid generated in the reaction, blocks the DMK polymerization reaction, thereby maintaining the yield of the target product DMK.

This invention provides a multi-scale neighborhood synergistic catalyst, its preparation method, and its applications. The method uses nitrogen-doped carbon nanotubes (NCNTs) as a structural platform, achieving precise construction of Al diatomic sites through vapor-phase migration, trapping, and reduction fixation of volatile metal precursors. Furthermore, it combines secondary vapor-phase deposition to drive the surface deposition and nucleation of metal-containing Y species, resulting in in-situ growth into metal nanoclusters to obtain Al2-Y. NC / NCNT catalyst. In this catalyst, Al species are atomically dispersed and exhibit coordination unsaturation, while metallic Y is anchored to its neighboring interface in the form of nanoclusters. Both maintain a stable nearest-neighbor structure under the confinement and anchoring effect of carbon nanotube doping sites. The Al2 sites can regulate the selective adsorption configuration and electronic state of reaction intermediates, while the Y nanoclusters provide efficient hydrogen molecule activation and overflow hydrogen supply channels. Together, they lower the energy barrier of key hydrogenation steps and suppress excessive hydrogenation side reactions. This invention features mild conditions, a simple process, and exhibits excellent hydrogenation activity and selectivity.

This invention discloses a ruthenium complex-modified nickel-based metal framework material, its preparation method, and its application in the electrocatalytic reduction of nitrate to ammonia. The method includes: adding a DMAC solution of terephthalic acid to an aqueous nickel chloride solution, mixing, adding the ruthenium complex, transferring the resulting solution to an autoclave for solvothermal treatment, immersing the resulting precipitate in an aqueous ammonium hexafluorophosphate solution, and stirring at room temperature to obtain RuNi-BDC. The introduction of the ruthenium complex, through the interaction between its organic ligands and the MOF framework, achieves high dispersion of ruthenium species, increases the exposure of active sites, and enhances the structural stability of the material. This system optimizes the adsorption energy for reaction intermediates, transforming the catalytic mechanism from single Ni catalysis to Ni-Ru bimetallic synergistic catalysis, effectively lowering the energy barrier of the rate-determining step of nitrate reduction, and improving the activity of the electrocatalytic nitrate reduction reaction, providing a new approach for achieving efficient electrocatalytic reduction of nitrate to ammonia.

The application provides a lipase mutant and application thereof, the lipase mutant of the application is that the 81th amino acid of the lipase with the amino acid sequence of SEQ ID NO:2 is changed from serine to leucine and / or the 164th amino acid is changed from valine to glutamic acid.The application realizes comprehensive optimization of enzyme catalytic conformation and reaction intermediate stability through a selected mutation strategy, so that a lipase mutant with significantly improved catalytic performance in the alpha-pinene epoxidation reaction is obtained.Compared with the wild-type lipase, the lipase mutant of the application can significantly improve the conversion rate of the alpha-pinene epoxidation reaction, and provides a high-quality enzyme source for efficient epoxidation of alpha-pinene.

The application discloses a preparation method of a cobalt-based non-noble metal catalyst and application of the catalyst in electrolysis of waste plastics, and belongs to the field of solid waste treatment and resource utilization. The application first obtains a precursor by self-assembly on a foam nickel substrate through a hydrothermal method, and then performs selenization treatment on the precursor by using a sodium borohydride reduction method to construct a heterostructure of CoBDC and CoSe. The obtained catalyst has a loose porous nanocluster shape, and the heterojunction interface is beneficial to optimizing electron distribution and effectively adjusting the adsorption behavior of a reaction intermediate on an active site, so that the activity and selectivity of electrocatalysis of a 1,4-butanediol oxidation reaction (BOR) are significantly improved, and the oxidation upgrading of PBS plastics is realized. The catalyst can efficiently convert PBS waste into high-value-added succinic acid (SA), and has both environmental benefits and economic benefits.

This invention provides a negative molecular glass photoresist compound based on hexabromotriptene, its synthesis method, and its applications, belonging to the field of photoresist resin technology. The negative molecular glass photoresist compound of this invention has a high glass transition temperature, a single molecular weight, and good thermal stability, which is beneficial for achieving high-resolution and low LWR / LER patterns. Compared with traditional positive photoresists, negative photoresists also have advantages such as high mechanical strength and low gas production, and can be widely used in the photolithography field. The synthesis process of the trimerptene derivative of this invention is simple, and the separation and purification of reaction intermediates and final products are convenient, making it suitable for industrial production. Furthermore, the core raw materials trimerptene and pinacol ester derivatives used are both produced domestically, which can completely solve the problems of high cost and difficult synthesis of semiconductor photoresists and their raw materials from the source, and has broad application prospects.

This invention belongs to the fields of medicinal chemistry and organic synthesis, specifically relating to a stable 3-aminocyclobutane-1,1-dicarboxylic acid diethyl oxalate and its application in the preparation of 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid. This invention effectively solves the technical bottlenecks of poor stability, difficulty in purification, and storage by converting unstable free 3-aminocyclobutane-1,1-dicarboxylic acid diethyl oxalate into a specific organic acid salt form. More importantly, this invention discovers that this organic acid salt can be directly used as a reaction intermediate, and can be used efficiently in subsequent amide condensation reactions with cholic acid or its active derivatives without the separation of free amines. This method significantly improves the purity and yield of the key intermediate and its downstream product 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid. The process is stable and simple to operate, providing a stable, controllable, and economical preparation route for the industrial production of 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid, a key active pharmaceutical ingredient in the liver cancer prodrug LLC-202.

This invention discloses a method for preparing and applying a hydrophobic MIL-160 / Cu2O heterostructure catalyst. The catalyst uses MIL-160 as a substrate, and the oxygen-containing functional groups on its surface anchor Cu through electrostatic interactions. 2+ Ultimately, a MIL-160 / Cu2O heterostructure was constructed. This heterostructure can repel water molecules and enrich carbon dioxide at the heterojunction interface, effectively suppressing the competitive hydrogen evolution reaction. Simultaneously, the strong electronic interactions at the heterojunction interface lower the energy barrier of the key C-C coupling step and stabilize the reaction intermediate. This catalyst is particularly suitable for the electrocatalytic reduction of carbon dioxide to ethylene and other high-value-added multi-carbon products, exhibiting high selectivity, high activity, and long-term operational stability.

This invention discloses a method for synthesizing H-AEEA-AEEA-OH, in which the side chains of smegglutinin and telpolide both contain the polyethylene glycol-modified H-AEEA-AEEA-OH, chemically named 17-amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic acid. The method of this invention features a short production cycle, mild reaction conditions, and is suitable for industrial production. The intermediates in each step of the reaction have high purity and high yield, with an overall yield exceeding 85%. The H-AEEA-AEEA-OH obtained by this method contains few impurities, and the specific impurities H-AEEA-OH and H-AEEA-AEEA-AEEA-OH are both small.

This invention discloses a catalyst for the production of 2,5-furandicarboxaldehyde from glucose and its preparation method. The catalyst uses ZSM-5 molecular sieve as a support, and through loading active components Nb and Ni, a multi-active-center system with a highly efficient synergistic effect is constructed via a staged heat treatment process involving oxidative calcination at 500 °C and hydrogen reduction at 400 °C. This invention utilizes the kinetic matching between the Nb and Ni components and the acid sites of the support to achieve an integrated and highly efficient conversion of glucose to DFF in DMF solvent, with a raw material conversion rate reaching up to 99%. Through the spatial synergy of the bimetallic active sites, the reaction intermediate 5-HMF can be produced and used immediately, effectively inhibiting coking and the formation of humic acid. This catalyst is not dependent on precious metals and possesses characteristics such as high activity, good stability, and excellent carbon balance, giving it a significant competitive advantage in the field of high-value utilization of biomass.

The present application relates to a kind of catalytic system for olefin hydroformylation reaction and the method of olefin hydroformylation reaction;Catalytic system includes: fluorine-containing bisphosphinite ligand Ln and rhodium-manganese bimetallic synergistic system.The present application also relates to the preparation method of fluorine-containing bisphosphinite ligand Ln.The fluorine-containing bisphosphinite ligand of the present application is creatively introduced, and its fluorine-containing structure can significantly enhance the chemical inertness of ligand molecule itself, effectively resist decomposition, hydrolysis and degradation under high temperature.The introduction of manganese can not only adjust the catalytic performance of rhodium center through electronic effect, but also can form synergistic effect with rhodium in the reaction, and stabilize the key reaction intermediate, so as to enhance the firmness of the entire catalytic framework at the molecular level, further inhibit the precipitation and agglomeration of rhodium metal and inactivation.In propylene hydroformylation reaction, the conversion rate is generally as high as 99%;In the wide process parameter interval, the conversion rate is not less than 96%, the activity window is wide, and it has great industrial application prospect and economic benefit.

The application discloses a method for preparing pyrone and 2-acetylpyridine flavor substances, and belongs to the technical field of food chemistry and food additives. The method comprises the following steps: (1) mixing fructose, pyrrolidine and water, adjusting pH, and heating to react; and (2) increasing the reaction temperature of step (1), performing second-stage heating, and introducing the gas-phase product formed by the reaction into an absorption bottle through a conduit. The pyrone is 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyrane-4-ketone, the molar ratio of fructose to pyrrolidine is 2-6:1 when the pyrone is prepared, and the molar ratio of fructose to pyrrolidine is 0.2-0.5:1 when the 2-acetylpyridine is prepared. The technical scheme of the application can precisely control the conversion path of reaction intermediates through a simple process, without adding special additives and complex equipment, and has the advantages of simple process, low cost, easy industrialization and good industrialization application prospect.

The application discloses a method for improving electrochemical carbon dioxide reduction to produce methane under acidic conditions of a copper-based catalyst by using potassium thiocyanate. The method adds potassium thiocyanate into an electrolyte for electrochemical carbon dioxide reduction under acidic conditions of a copper-based catalyst, or simultaneously adds a potassium ion-containing salt and a thiocyanate ion-containing salt, and the existing potassium thiocyanate salt in the electrolyte can effectively regulate the electronic structure of a Cu surface, promote deep hydrogenation of an intermediate in a carbon dioxide reduction reaction, thereby improving the selectivity of methane synthesis, and meeting the needs of industrialized carbon dioxide electro-reduction to produce methane.

The application provides an oil-based drilling fluid stabilizer and application thereof. The stabilizer comprises a graft structure with active silanol groups and ester groups, and is obtained through dehydration esterification reaction of a first reaction intermediate, a second reaction intermediate and a first catalyst under mixing and heating in a solvent; wherein the first reaction intermediate is prepared based on nano-laponite and gamma-aminopropyl triethoxysilane; and the second reaction intermediate is prepared based on oleic acid and triethanolamine. The stabilizer can slow down the influence of compressibility on drilling under the condition that the system maintains a relatively low oil-water ratio, and helps to improve emulsion stability and system sedimentation stability.

The application belongs to the technical field of biochemical analysis, and more particularly relates to a SOX-HRP double-enzyme conjugate, a preparation method and application thereof. The SOX-HRP double-enzyme conjugate provided by the application can significantly shorten the substrate diffusion distance between enzymes, directly transfer reaction intermediates from the active center of the oxidase to the active center of the peroxidase in the nanometer scale, effectively reduce side reactions in the diffusion process, and thus realize strong anti-interference optical detection.

The application belongs to the field of organic photochemical synthesis and catalysis technology, and discloses application of a spin catalyst based on a macrocyclic gadolinium complex in a photo-oxidation-reduction reaction. The spin catalyst utilizes the high-spin ground state of gadolinium ions, promotes intersystem crossing of a singlet radical ion pair to a triplet radical ion pair in a photo-reaction intermediate through paramagnetic effect, and effectively inhibits the reverse electron transfer process. In particular, the Gd-DOTP complex in an aqueous system induces the formation of an ordered hydrogen bond network of solvent water molecules through phosphonic acid groups on the ligand, constructs a proton-mediated spin transport channel, and can achieve efficient catalysis at a low concentration (0.5-3.0 mM) of millimolar level. The system significantly inhibits BET and improves the efficiency of organic photo-oxidation-reduction reactions, is suitable for halogenated aromatic hydrocarbon dehalogenation, benzylic oxidation hydroxylation and the like, and has the advantages of small catalyst dosage, good stability and wide application range.

This invention discloses a method for preparing L-glufosinate or its salts. The method involves reacting an L-cycloamide with methylphosphonic dichloride in the presence of an acid-binding agent and a monoalkyl methylphosphonite ester to undergo phosphination and cyclization reactions, yielding an intermediate as shown in formula (4). This intermediate then undergoes Arbuzov rearrangement under the action of a rearrangement initiator to obtain an intermediate as shown in formula (5). Finally, the intermediate is reacted to obtain the L-glufosinate or its salts. The L-glufosinate preparation method provided by this invention uses a monoalkyl methylphosphonite ester, which is particularly suitable for dissolving chiral cycloamides, as a solvent and reaction intermediate. It has advantages such as high yield, simple synthesis steps, mild reaction conditions, and complete solvent reuse, making it suitable for industrial production.

The application belongs to the field of catalyst materials and electrochemistry, and particularly relates to a cobalt phosphide supported Ru monatomic catalyst and a preparation method and application thereof. By introducing 1,10-phenanthroline and urea as a regulator and combining with a joule heat treatment technology, high loading, high dispersion and strong anchoring of Ru monatomic atoms on the cobalt phosphide carrier are realized. The core lies in that the monatomic atom agglomeration is inhibited by molecular modification and rapid heat activation, and the metal-carrier interaction is enhanced, so that the atomic dispersion is improved, and the active site density is significantly increased. The prepared catalyst has rich defect structure and excellent conductivity, can provide a large number of uniform active centers for electrocatalytic reaction, and promotes charge transmission. In OER, the catalyst shows high activity and stability, and the performance advantage is derived from the electronic synergistic effect between the high loading monatomic atom and the carrier, and the optimized adsorption capacity of the defect site to the reaction intermediate.

This invention provides a Schiff base-based intumescent flame retardant with a nanosheet structure, its preparation method, and its application. The invention first obtains a reaction intermediate through a Schiff base reaction, then uses the reaction intermediate to exfoliate boron nitride to prepare modified boron nitride nanosheets. Next, a phytic acid metal salt solution is reacted with the modified boron nitride nanosheets to form a salt, thereby preparing a Schiff base-based intumescent flame retardant with a nanosheet structure composed of nitrogen, sulfur, phosphorus, boron, and metal ions. This intumescent flame retardant can improve the flame retardant and smoke-suppressing properties and mechanical properties of WPC (wax-carbon polymer).

The application provides a chlorine-resistant chromium-ruthenium oxide catalyst based on seawater electrolysis, a preparation method and application, and belongs to the technical field of electrocatalytic materials. The method comprises the following steps: dissolving a ruthenium metal salt and a chromium metal salt in an ethanol solution to obtain a mixed solution; adding a citric acid solution to the mixed solution, mixing and then drying to obtain a dried powder; calcining the dried powder in air to obtain a CrRuO x Chromium-ruthenium oxide catalyst. The chlorine-resistant chromium-ruthenium oxide catalyst prepared by the application can adsorb OH ‑ or water molecules by means of chromium as a Lewis acid site, which not only realizes hydroxyl overflow to effectively repel chloride ions, inhibits the competitive chlorine evolution reaction of the anode in seawater electrolysis, and relieves the corrosion of chloride ions on the catalyst, but also can regulate the interface hydrogen bond network to optimize the adsorption of reaction intermediates, and significantly improves the catalytic activity.

The application provides a diatomic copper-doped catalyst and a preparation method and application thereof, and the catalyst is a carbon material doped with a structural unit shown in formula I in a molecular structure. The diatomic metal catalyst copper catalyst constructed by the application can adjust the adsorption / desorption energy of an electrocatalytic reaction intermediate through metal-metal synergistic effect, so that the selectivity of the electrocatalytic reaction is significantly improved.