2949 results about "Ketone" patented technology

Methods and systems for converting a renewable fuel intermediate composition to finished transportation fuel are provided herein. In some examples, a renewable fuel intermediate composition is flowed over a first catalyst in a first reaction zone to generate a saturated, hydrodeoxygenated product. A liquid portion of the renewable fuel intermediate composition may be characterized as having more than about 70 wt % of the oxygen being within ketone groups. The saturated, hydrodeoxygenated product may be flowed over a second fixed-bed catalyst in a second reaction zone to generate a product including the finished transportation fuel.

Glucose and ketones may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using an analyte sensor capable of detecting both analytes. Certain analyte sensors capable of dual detection may comprise a first working electrode and a second working electrode, a ketones-responsive active area disposed upon a surface of the first working electrode, a glucose-responsive active area comprising a glucose-responsive enzyme disposed upon a surface of the second working electrode, a membrane having a first portion overcoating the ketones-responsive active area and a second portion overcoating the glucose-responsive active area, in which the first portion and the second portion have different compositions. The ketones-responsive active area comprises an enzyme system comprising at least two enzymes that are capable of acting in concert to facilitate detection of ketones.

The invention provides a carbonyl reductase mutant. The carbonyl reductase mutant is obtained by performing single-point mutation or multi-point combined mutation on the 17th site, the 40th site and the 64th site of an amino acid sequence as shown in SEQ ID NO.1. The invention also provides a coding gene, a recombinant vector containing the coding gene, a co-expression engineering bacterium and an application of the co-expression engineering bacterium. Compared with a wild type enzyme, the carbonyl reductase mutant has high activity and high stereoselectivity, the enzyme activity can reach more than two times that of the wild type enzyme, the catalytic efficiency on a substrate precursor ketone is remarkably improved, the yield of a statin drug intermediate and chiral alcohol synthesized by an enzyme method of the carbonyl reductase mutant is remarkably improved, and the yield of a rosuvastatin intermediate (3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R) is remarkably improved. The highest yields of the (3R, 5R)-6-chloro-3, 5-dihydroxyhexanoic acid tert-butyl ester and the atorvastatin intermediate (3R, 5R)-6-cyano-3, 5-dihydroxyhexanoic acid tert-butyl ester reach 99% and 97.6% respectively, e.e. Is larger than 99%, and the method has high industrial application value.

The invention discloses a deep eutectic solvent / bimetal organic framework co-catalyzed straw polyol as well as a preparation method and application thereof, the straw polyol is prepared by the following method: uniformly mixing straw powder, small molecular alcohol, an acid catalyst and a deep eutectic solvent in a nitrogen atmosphere, and reacting to obtain a reaction product; and adding a bimetal organic framework catalyst into the reaction product, and reacting to obtain the straw polyol. A green, natural and pollution-free eutectic solvent catalytic liquefaction technology is adopted, lignin and hemicellulose can be dissolved, the cross-linking effect between lignin and hemicellulose and cellulose is reduced, the crystalline structure of cellulose can be destroyed, the available surface area is increased, the contact with a liquefying agent is enhanced, the conversion efficiency is improved, and the residue rate is reduced; the bimetallic organic framework catalyst is added in the middle and later periods of the reaction, aldehydes, ketones and acid and ester substances can be reduced and upgraded into alcohols, the hydroxyl value of the liquefied polyol is greatly increased, and the film-forming crosslinking degree is improved.

The invention discloses a fine circuit pattern anti-diffusion agent as well as a preparation method and a use method thereof, and relates to the technical field of printed circuit board manufacturing. The fine circuit pattern anti-diffusion agent is prepared from the following components in percentage by mass: 0.05 to 0.3 percent of an oleophobic agent, 0.1 to 0.6 percent of a bonding agent, 0.2 to 1.5 percent of an adhesion promoter, 0.5 to 4.0 percent of a wetting agent, 0.5 to 5.0 percent of a cosolvent and the balance of water, the oleophobic agent is a fluorophenylethylamine derivative, the bonding agent is a carbonyl chloride derivative, the adhesion promoter is a sulfur heterocyclic alkane derivative, the wetting agent is a methylsiloxane silane derivative, and the cosolvent is a sulfonyl ketone derivative. According to the fine circuit pattern anti-diffusion agent, an organic layer can be formed on the copper surface of a circuit board, the binding force between the copper surface and printing ink is enhanced, jet printing printing ink is prevented from diffusing on the copper surface, and the product percent of pass of a jet printing solder mask process is improved.

The invention discloses a rare-earth metal arylamine group compound as well as preparation method and application thereof. The invention discloses the rare-earth metal arylamine group compound which is characterized in that a general formula of the rare-earth metal arylamine group compound is (2,6-R12PhNH)5LnLi2(THF)2, wherein Ln is a rear-earth metal selected from one of neodymium, samarium, ytterbium or yttrium; R1 is selected from one of hydrogen, methyl or isopropyl. The rare-earth metal arylamine group compound has the advantages that the rare-earth metal arylamine group compound has a definite structure; raw materials used in the preparation method are simple, easily obtained and cheap; the reaction process is simple and easily operated; the rare-earth metal arylamine group compound product is conveniently purified and the yield of the product is high; the rare-earth metal arylamine group compound has a high activity when acting as a single component catalyst to catalyze a hydrogen phosphine reaction of aldehyde or ketone and phosphite ester; the use amount of the catalyst is less; the yield is high; a substrate has wide universality; a new and simple method is provided for synthesis of a-hydroxyphosphonate.

The invention relates to the technical field of high-performance composite materials, and discloses a method for preparing a polyetherketoneketone composite powder based on rapid phase separation of a high-boiling point coagulant and efficient solvent recovery. The preparation method of the invention comprises: using a fluorine-based and / or chlorine-based polar solvent to dissolve short carbon fiber and polyetherketoneketone, and obtaining a homogeneous mixed solution after stirring; pouring the mixed solution into a high-boiling point coagulant, stirring to fully solidify the short carbon fiber / polyetherketoneketone, and obtaining a short carbon fiber / polyetherketoneketone composite block and a fluorine-based and / or chlorine-based polar solvent / high-boiling point coagulant mixed solution; washing, drying, and grinding the composite block to obtain a short carbon fiber / polyetherketoneketone composite powder; fractionating the solvent / coagulant mixed solution to obtain a reusable fluorine-based and / or chlorine-based polar solvent and a high-boiling point coagulant. The material of the invention provides a rapid and complete phase separation means, an effective solvent recovery strategy, and a high-performance composite powder for industrial preparation of composite powder by a solution method.

The invention belongs to the technical field of chemical production, and particularly relates to an efficient energy-saving refining system for producing cyclohexanone through dehydrogenation, which comprises an alcohol tower, a dehydrogenation heat exchanger, a dehydrogenation reactor, an alcohol tower feeding heat exchanger, a dehydrating tower, a light tower I, a light tower II, a ketone tower and an alcohol recovery tower which are connected in sequence, a middle feeding port of the alcohol tower is communicated with a tube pass discharging port of the alcohol tower feeding heat exchanger, a top discharging port of the alcohol tower is communicated with a tube pass feeding port of the dehydrogenation heat exchanger, a bottom discharging port of the alcohol tower is communicated with a middle feeding port of the alcohol recovery tower, and an alcohol ketone drying tower is additionally arranged between the alcohol tower feeding heat exchanger and the dehydration tower. A feed port of the alcohol ketone drying tower is communicated with a shell pass discharge port of the alcohol tower feed heat exchanger, and a liquid phase discharge port of the alcohol ketone drying tower is communicated with an upper feed port of the dehydrating tower. The alcohol tower adopts a process that raw materials directly enter the tower top, tower top reflux is cancelled, steam consumption is reduced, and the purpose of saving energy is achieved.

The invention belongs to the technical field of hair care products, and particularly relates to composite acid gel for scalp care and a preparation method thereof. Salicylic acid, glycolic acid, piroctone azelate olamine salt, echinacea purpurea-lactic acid bacteria yeast, an emulsifier and water are combined, wherein the echinacea purpurea-lactic acid bacteria yeast is prepared by performing enzymolysis on echinacea purpurea through bacillus subtilis protease and then performing aerobic fermentation with lactic acid bacteria. Salicylic acid, glycolic acid and azelaic acid in the composite acid gel are compounded, so that stimulation of salicylic acid is weakened, and the effect of dissolving hair follicle grease is reserved; glycolic acid and azelaic acid are added to accelerate keratin metabolism, regulate sebum secretion and create safe and healthy shielding for the scalp environment, and polysaccharide and flavonoid compounds in the echinacea purpurea-lactic acid bacteria leavening are beneficial to exerting the anti-oxidation and immune regulation effects of the echinacea purpurea-lactic acid bacteria leavening. Therefore, the composite acid gel provided by the invention is green, safe and non-irritant, the preparation method is simple and convenient, and the composite acid gel can be used for inhibiting bacteria and reducing scalp inflammation.

The invention provides a novel chiral ferrocene bridged binaphthyl skeleton phosphine ligand and application thereof. The ligand has the advantages of low cost, simplicity in synthesis, air stability and the like. The ligands have good catalytic activity and enantioselectivity in the asymmetric hydrogenation reaction of ketone, and have certain industrial application prospects in the synthesis of pharmaceutical molecules.

The present application relates to ketol reductoisomerase variants, polynucleotides encoding the variants of the present disclosure, L-valine-producing microorganisms comprising the ketol reductoisomerase variants of the present disclosure or the polynucleotides encoding the variants, and methods of producing L-valine using the microorganisms of the present disclosure.

The present application provides an electrolytic solution for magnesium batteries, a method for preparing the same, and a magnesium battery, comprising a non-aqueous solvent and an electrolyte salt, wherein the non-aqueous solvent is selected from one or more of imidazole ionic liquids, pyrrole ionic liquids, piperidine ionic liquids, ether compounds, ester compounds, pyridine compounds, nitrile compounds, sulfone compounds, or ketone compounds; the electrolyte salt has a chemical formula [MgmLinXo(HMDS)2m+m−oRp]·Mq. The electrolytic solution for magnesium batteries provided by the present application is endowed with good stability, strong water resistance and impurity resistance, and excellent electrochemical performance under the mutual synergistic effect among the components, and excellent electrochemical performance under the mutual synergistic effect among the components, and at the same time, the electrolytic solution can promote reversible deposition-dissolution of magnesium, reduce the over-potential, inhibit formation of a passivation layer of magnesium salts on the surface of the anode, and increase the charging-discharging specific capacity and cycling stability of the magnesium battery.

The invention discloses a polyetherketoneketone high-temperature-resistant wear-resistant non-stick coating and a preparation method thereof. The coating is prepared from the following components in parts by mass: 13 to 30 parts of a resin matrix group (containing 12 to 25 parts of titanium modified polyether ketone ketone resin, 1 to 5 parts of fluorine-free viscous resin and 0.65 to 6 parts of aluminum oxide), 0.5 to 3 parts of a nano reinforced group (containing 0.5 to 3 parts of KH-550 modified nano titanium dioxide, 0.025 to 0.6 part of cerium dioxide and 0.5 to 3 parts of boron nitride) and 62 to 71 parts of an auxiliary agent group. The preparation method comprises the following steps: 1) taking diphenyl ether, paraphthaloyl chloride and isophthaloyl chloride as monomers, and synthesizing titanium modified polyether ketone ketone resins with different viscosities through segmented polymerization (1.5-2.0 hours or 3.0-4.0 hours); 2) respectively preparing a smooth bottom layer water dispersion slurry and a wrinkled surface layer water dispersion slurry; and (3) forming a compact bottom layer and a micro-wrinkle surface layer on the base material by adopting a layered spraying and stepped sintering process (280-320 DEG C, 10-20 minutes). The whole system of the coating is fluorine-free and has temperature resistance gt; the coating has the characteristics of high temperature resistance (350DEG C), wear resistance (Taber wear rate of 3-5mg / 1000r), non-sticking (contact angle gt, 100 DEG C) and heavy corrosion resistance, and is suitable for cooking utensils and chemical equipment.

S-Beta-hydroxybutyric acid compositions for oral delivery are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and / or as a gel or suspension. By limiting added beta-hydroxybutyrate salts containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be pure S-beta-hydroxybutyric acid or a non-racemic mixture enriched with S-beta-hydroxybutyric acid relative to R-beta-hydroxybutyric acid.

The invention belongs to the field of flexible piezoelectric polymer materials, and discloses a polyvinylidene fluoride based ferroelectric polymer and a preparation method thereof. The preparation method comprises the following steps: (1) adding an inorganic alkaline reagent into a polyvinylidene fluoride-trifluoroethylene ferroelectric polymer solution, carrying out dehydrofluorination and nucleophilic addition-elimination reaction to generate a polymer with an enol structure, and then washing, precipitating and purifying a reaction product; and (2) re-dissolving by using an organic solvent, then forming a film by using a tape casting method, and carrying out ketone-enol tautomerization reaction in the film forming process of the tape casting method to finally prepare the polyvinylidene fluoride based ferroelectric polymer film. According to the effective modification and preparation method disclosed by the invention, an enol structure is promoted to be converted into a more stable ketone structure through a ketone-enol tautomerization reaction by utilizing a high-temperature environment in a film forming process, so that C = O double bonds are introduced into a polymer chain, and the piezoelectric property of the polymer is remarkably enhanced.

The invention provides an anion exchange polymer and a preparation method thereof and an anion exchange membrane, the anion exchange polymer comprises a chain segment I and / or a chain segment II, the structural formula of the chain segment I is # imgabs0 #, the structural formula of the chain segment II is # imgabs1 #, A is nitrogen-containing heterocyclic ketone, Ar1 is a first aryl structural unit, Ar2 is a second aryl structural unit, and the structural formula of the chain segment II is # imgabs1 #. M <-> is a trifluoroacetic acid ion and / or a p-toluenesulfonate ion. The anion exchange polymer disclosed by the invention is relatively low in toxicity to a catalyst, so that the anion exchange polymer shows excellent electrochemical performance.

The present invention discloses a method for synthesizing 9-bromoanthracene. Anthracene and potassium bromide are used as raw materials. The final product, 9-bromoanthracene, is obtained by reacting anthracene and potassium bromide in the presence of ferric chloride and 1-acetoxy-1,2-benzidoxyl-3-(1H)-ketone. The method has the advantages of being inexpensive and readily available, easy to produce, and readily purifiable, and can be developed into an industrialized production method.

The invention discloses a nitrogen-containing carbon hollow sphere supported cobalt-based catalyst as well as a preparation method and application thereof, and belongs to the technical field of catalyst preparation. According to the preparation method, ammonia water, tetraethyl orthosilicate, polyoxyethylene polyoxypropylene ether triblock copolymer, resorcinol and a formaldehyde solution are fully reacted in a mixed solvent of deionized water and ethanol by virtue of a template method, and the nitrogen-containing carbon hollow spheres are obtained after calcination and etching; then carrying out surface modification on the nitrogen-containing carbon hollow spheres, and uniformly loading cobalt metal by virtue of the structure guiding effect of hexamethyleneimine and sodium citrate dehydrate; the prepared nitrogen-containing carbon hollow sphere supported cobalt-based catalyst has abundant highly-exposed Co-N-C active sites, has wide substrate universality, has good catalytic activity and selectivity for amination reactions with various long-chain fatty aldehydes, fatty ketones, cyclic fatty ketones, aromatic aldehydes and ketones as raw materials, and can realize efficient catalytic amination reactions of carbonyl compounds.

The invention discloses a hydroxylamine sulfate preparation method, which comprises: S1, carrying out analysis on caprolactam sulfate with water or a hydroxylamine sulfate aqueous solution to obtain a caprolactam sulfuric acid aqueous solution; extracting and separating the caprolactam sulfuric acid aqueous solution by using an extracting agent, conveying an extraction phase caprolactam organic solution to a caprolactam device for treatment, and entering a step S2 into a raffinate phase sulfuric acid aqueous solution or hydroxylamine sulfate and sulfuric acid aqueous solution; s2, adding ketoxime and a sulfuric acid aqueous solution or hydroxylamine sulfate and the sulfuric acid aqueous solution to generate a hydrolysis reaction to generate a hydroxylamine sulfate aqueous solution and ketone, and after ketone separation, sending the ketoxime to a ketoxime preparation device; s3, carrying out steam stripping separation on the hydroxylamine sulfate aqueous solution, sending unreacted ketoxime to the step S2 to participate in a hydrolysis reaction, and carrying out concentration crystallization, centrifugal filtration and drying dehydration on the hydroxylamine sulfate aqueous solution to obtain hydroxylamine sulfate; and S4, returning part of hydroxylamine sulfate raffinate subjected to centrifugal filtration to the step S1 for resolving caprolactam sulfate, and carrying out oximation reaction treatment on the residual hydroxylamine sulfate raffinate and ketone.

The invention relates to the technical field of liquid chromatography, and discloses a mixed product liquid chromatography comprehensive analysis method which comprises the following steps: S1, mixing products: respectively mixing aldehyde compounds and ketone compounds with different mobile phases, and then injecting into an injection chromatographic system; s2, liquid chromatographic analysis: separating and analyzing a mixed product by using a liquid chromatograph; s3, performing qualitative analysis; on the basis of liquid chromatographic analysis, each peak in a chromatogram is identified. The method aims at qualitative and quantitative analysis of main substances (groups) in an organic reaction mixed product system; the method is suitable for analyzing the relative percentage content of products related to organic chemical reactions such as raw materials (nonylphenol) related to a core production process, nonylphenol formylation reaction, nonylphenol esterification reaction, phenolic ester Fris rearrangement reaction and the like, and samples in a refining process; the influence of absorption peaks and chromatographic line oscillation of other non-target substances on the content analysis result can be effectively avoided.

The invention relates to a high-efficiency preparation method of a Ritlecitinib key intermediate, which comprises the following steps: reacting (2S)-1-substituent-2-methylpiperidine-5-ketone with 4-amino-7H-pyrrolo [2, 3, d] pyrimidine to form imine, and carrying out chiral induction on the imine in the presence of a reducing agent to obtain a single chiral 4-(N-((3R, 3R)-4-(4-((3R, 3R)-4-(4-amino-7H-pyrrolo [2, 3, d] pyrimidine-5-ketone)-4-amino-7H-pyrrolo [2, 3, d] pyrimidine-5-ketone)-4-amino-7H-pyrrolo [2, the preparation method comprises the following steps: adding 2-(2, 6, 6, 6, 6-tetramethylpiperidine-3-yl)) amino-7H-pyrrolo [2, 3, d] pyrimidine into a reaction kettle, and carrying out deprotection to obtain a target product. Compared with the existing method, the method has the characteristics of short synthetic route, good selectivity, easiness in industrialization and the like.

The invention discloses a method for efficiently synthesizing epiinositol by catalyzing muscle inositol through double-enzyme cascade, and belongs to the field of biological catalysis engineering. According to the invention, scyllo-inositol dehydrogenase is mutated to obtain a beneficial mutant C261R, and the beneficial mutant C261R is coupled with heat-resistant myo-inositol dehydrogenase to efficiently catalyze and synthesize the epiinositol, and belongs to the field of biological catalysis engineering. The new way for synthesizing the epiinositol is completely different from reported synthesis methods of scyllo-inositol and D-chiro-inositol, and comprises the following steps of: firstly dehydrogenating the C4 position of the muscle inositol to form an intermediate product ketone, and then hydrogenating to realize chiral inversion of hydrogen at the C4 position, so as to obtain the final product epiinositol. The invention provides a brand new way for biocatalytically synthesizing the epiinositol, the yield of the obtained epiinositol is 1.39 g / L, the conversion rate is 38.7%, the yield and the conversion rate are the highest level which is publically reported at present, the biosynthesis process is simple to operate, low in cost, green and environment-friendly, and a solid research foundation is laid for industrial production of the epiinositol.

The invention discloses a chiral amine reagent and a preparation method thereof as well as a method for analyzing and splitting a chiral drug, the chiral amine reagent is APMA # imgabs0 # or d5-APMA # imgabs1 #, and the configuration of a carbon atom connected with an amino group on a piperidine ring in the structural formula is an S configuration. The APMA and d5-APMA provided by the invention can be used for analysis and detection of chiral drugs, 3-aminocyclohexyl-phenyl methane ketone (APMA) and the d5-APMA in a stable isotope form thereof are independently or jointly used as a pair of isotope labeling reagents and are subjected to condensation reaction with the chiral drugs to obtain derivatives, enantiomers of the chiral drugs can be effectively split, and the chiral drugs can be analyzed and detected. And an easy-to-ionize group is introduced, so that the mass spectrum response in an ESI positive ion mode is greatly improved.

Compounds of formula (I), processes for their preparation and their use in medicine. Specifically, provided are compounds of formula (I) or stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, and also relate to pharmaceutical compositions containing these compounds and uses of the compounds in drugs for treatment and / or prevention of cardiovascular diseases. These compounds are inhibitors of myeloperoxidase (MPO). # imgabs0 #

The present disclosure is directed to UstD mutants capable of producing non-canonical amino acids that contain secondary or tertiary alcohols at the gamma position, and methods of using the mutants to produce the non-canonical amino acids. The mutants can use aldehyde-containing substrates and ketone-containing substrates to generate the secondary and tertiary alcohol groups, respectively.

The present invention relates to bio-based bisphenol monomer of formula I and process of preparation thereof. Specifically, the present invention relates to bio-based bisphenol monomers of formula I containing multiple alkoxyl groups, and polyphenols. The bisphenol monomers of formula I contain built-in methoxyl groups, which represent latent phenolic hydroxyl groups and could conveniently be de-blocked to phenolic hydroxyl groups leading to formation of polyphenols containing catechol / phloroglucinol units with anti-oxidant properties and are potentially useful in various applications like cosmetics, polymer additives and so on. Further, the present invention relates to process of preparation of polymers using bisphenol monomer of formula I as valuable building blocks wherein the high performance thermoplastics are poly(ether sulfone)s, poly(ether ether ketone)s, polyesters, polycarbonates, polyphosphonates, etc. and thermosetting resins are epoxies, cyanate esters, phthalonitriles, propargyl ethers, etc.

The invention discloses a weather-resistant anti-aging polypropylene material and a preparation method thereof. The weather-resistant and anti-aging polypropylene material is prepared from polypropylene resin, vinyl amino compound grafted polypropylene, modified filler, an ultraviolet light absorber, a hindered amine light stabilizer, an antioxidant and an acid remover, the vinyl amino compound grafted polypropylene is prepared by carrying out free radical copolymerization reaction on polypropylene and a vinyl amino compound in a reaction solvent; the reaction solvent comprises a main solvent and a cosolvent in a mass ratio of 100: (0.5-1.2); the main solvent is selected from xylene or decahydronaphthalene, and the cosolvent is selected from N, N-dimethylformamide or methyl ethyl ketone. The invention aims to improve the compatibility of the weather-resistant auxiliary agent and polypropylene resin, solve the degradation effect of a traditional maleic anhydride grafted polyolefin compatilizer on a polypropylene matrix, and improve the weather resistance and aging resistance of a polypropylene material.

The invention provides a preparation method of a bexagliflozin intermediate, and relates to the technical field of organic synthesis. The preparation method provided by the invention comprises the following steps: S1, substitution reaction: under the action of alkali, carrying out substitution reaction on 2-(cyclopropoxy) ethanol and a compound III ((5-halogen-2-chlorphenyl) (4-halophenyl) ketone) to generate a compound II; s2, reduction reaction: under the action of lewis acid, carrying out reduction reaction on a reducing agent and a compound II ((5-halogen-2-chlorphenyl) (4-(2-(cyclopropoxy) ethyoxyl) phenyl) ketone) to generate a compound I; the method has the advantages of mild reaction conditions, high atom utilization rate, high yield, high product quality and the like.

The invention belongs to the technical field of fine chemical engineering, and particularly discloses a method for preparing a broad-spectrum bactericide 2-n-butylbenzo [d] isothiazole-3 (2H)-ketone by a molecular editing method. The preparation method comprises the following specific steps: taking 3H-1, 2-benzodisulfophenol-3-ketone and n-butylamine as raw materials, taking Selectfluor as an additive, adding the raw materials and the additive into a mixed solvent, and carrying out heating and stirring reaction, so as to obtain the target product 2-n-butylbenzo [d] isothiazole-3 (2H)-ketone (BBIT). The method is simple and convenient to operate, the raw materials are easy to obtain, the yield is high, thiophenol raw materials or excessive alkali are prevented from being used, and potential application value is achieved.

The invention provides a quinolinyl ketone compound as well as a preparation method and application thereof, and belongs to the technical field of compounds containing two or more heterocyclic rings. The quinolinyl ketone compound can be obtained by taking enaminone, a perfluoroalkane compound and aminobenzene as raw materials, adding an organic solvent and alkali and stirring and reacting in an argon atmosphere and under blue light irradiation. The prepared product has good antibacterial activity, the preparation condition is mild, and the yield is basically kept at 80% or above and can reach 90% to the maximum.