104 results about "Thioester" patented technology

The invention discloses a mercury ion detection fluorescent probe based on quinoline as well as a preparation method and application of the mercury ion detection fluorescent probe. The fluorescent probe and a structural formula of the fluorescent probe are shown as a formula I in the specification. A quinoline derivative, namely 2-methyl-7-hydroxyquinoline, is used as a fluorescent chromophore, a thioester group is used as a recognition group, and the prepared fluorescent probe shows high sensitivity and high selectivity on Hg < 2 + > in a solution. The preparation method of the fluorescent probe is simple in steps, raw materials are easy to obtain, and the obtained product is a white flocculent solid, is easy to store, has a wide application prospect and can be produced and applied on a large scale.

The invention relates to a cable sheath material, and particularly discloses a weather-proof low-smoke halogen-free flame-retardant polyolefin cable sheath material and a preparation method thereof. The cable sheath material is prepared from 30 to 45 parts of low-density polyethylene, 10 to 30 parts of high-impact homo-polypropylene, 15 to 30 parts of graft modified flexibilizer, 30 to 50 parts of main flame retardant, 1 to 5 parts of coupling agent, 10 to 30 parts of phosphorus-nitrogen synergistic flame retardant, 4 to 10 parts of efficient smoke suppressant, 0.2 to 0.8 part of hindered phenol main antioxidant, 0.4 to 1.2 parts of thioester auxiliary antioxidant, 0.4 to 1.0 part of hindered amine light stabilizer, 0.5 to 1.5 parts of ultraviolet light absorber and 2.5 to 2.5 parts of weather resistance enhancer. 5.0 parts of a lubricant, 0.5 to 2.0 parts of a lubricant, and 0.1 to 0.8 part of an anti-copper agent. The mechanical property, the electrical insulation property and the weather resistance of the sheath material are effectively improved, an efficient synergistic flame retardant effect can be obtained, the flame retardant property is excellent, and a finished product can obtain excellent weather resistance, low-smoke zero-halogen property, flame retardant property, mechanical property, electrical insulation property and the like.

The invention discloses a stabilizer for a transparent PVC (Polyvinyl Chloride) product with good gamma-ray irradiation resistance. Comprising the following components in parts by weight: 10-20 parts of benzoic acid organic calcium salt, 10-20 parts of benzoic acid organic zinc salt, 10-20 parts of benzoic acid organic magnesium salt, 10-20 parts of benzoic acid organic aluminum salt, 20-30 parts of hydrotalcite, 5-10 parts of borate, 3-10 parts of a pyrimidine auxiliary color retention agent, 3-10 parts of a hindered amine light stabilizer and 5-10 parts of a thioester antioxidant. The hindered amine light stabilizer is a light stabilizer with a hindered amine methyl piperidine structure. The transparent PVC product added with the stabilizer has excellent gamma-ray irradiation resistance, and after the irradiation dose is 25kGy, the yellowness index YI of the transparent PVC product is less than 5.0, which indicates that the transparent PVC product added with the stabilizer does not change color in later application and storage processes after gamma-ray irradiation; the transparency is kept well, the light transmittance after irradiation is greater than 85%, and the transparency requirements of medical and food packaging are met; the mechanical property is well maintained, and the tensile strength retention rate after irradiation is greater than 90%.

The present disclosure provides extruded or spun semi-permeable porous hollow fibers comprising covalent ester, thioester, and / or amide cross-linked polypeptides and methods of producing the same. The hollow fibers may be produced from proteins, protein extracts and / or protein isolates derived from plants, animals, bacteria, algae, archaea and / or fungi and, in certain embodiments, are intended to be suitable for human and / or animal ingestion. In some embodiments, the hollow fibers may be designed for producing cartridges compatible with existing and / or novel bioreactor platforms for containing cell cultures in cultured meat production.

The present application relates to a composite stabilizer of 2-bromo-3,3,3-trifluoropropene and its use method, the composite stabilizer comprises: a phenolic compound, a phosphite or thioester compound, an acid binding agent, the molar ratio of the amount of the three substances is 1:0.1~6:0.1~6, and the mass ratio of the amount and 2-bromo-3,3,3-trifluoropropene is 0.001~1.0:100. Through the interaction between the above stabilizer components, the rectification process of the product can effectively inhibit the deterioration problems such as the increase of acid value, the color change to yellow and the decrease of purity of 2-bromo-3,3,3-trifluoropropene, provide excellent long-term stability, facilitate its production, transportation and storage, and ensure its smooth application in the field of new fire extinguishing agent, organic synthesis and the like.

The invention relates to aminoethyl thioesters of saturated carboxylic acids, of a short chain acid, and a bile acid, therapeutic compositions containing such aminoethyl thioesters, and a method of improving the health of an animal or of treating of ameliorating a health disorders in an animal by administering to the animal an effective amount of a therapeutic composition comprising an inventive aminoethyl thioester of a carboxylic acid.

The application discloses a synthesis method of a thioester functionalized 2-oxoindole, and belongs to the technical field of organic synthesis. The method is to use an iodine acetyl aniline derivative and a thioester as raw materials, to add a base and a solvent under the action of a palladium catalyst and a ligand, to perform one-pot reaction, and to synthesize a series of thioester functionalized 2-oxoindole compounds at a temperature of 70-100 DEG C. The reaction avoids directly using toxic CO gas or a strong stimulating gas smell aryl thio phenol or thiol and other substances, and has the advantages of mild reaction condition, simple operation, strong substrate universality, easy availability of raw materials, high yield, easy separation of target products and the like.

A process for preparing preferably degradable copolymers by free radical ring-opening polymerization using thionolactone monomers or thionocarbonate monomers, in the presence of a radical polymerization initiator. Also, the copolymers, which include thioester or thiocarbonate bonds, that are obtained by carrying out the process including the free radical ring-opening polymerization using thionolactone monomers or thionocarbonate monomers.

This invention provides a high-transmittance, yellowing-resistant epoxy resin film and its preparation method. The epoxy resin film comprises the following raw materials in parts by weight: 30-35 parts liquid epoxy resin, 25-35 parts solid epoxy resin, 20-30 parts toughening agent, 5-8 parts aromatic diamine curing agent, 3-5 parts terminal amino triazine / Schiff base curing agent as shown in Formula I, 0.3-0.5 parts accelerator, 1-2 parts coupling agent, 0.1-0.3 parts defoamer, 0.5-0.8 parts thioester antioxidant, and 50-100 parts solvent. The curing agent as shown in Formula I, on the one hand, contains Schiff base bonds (C=N) and triazine ring structures with strong absorption and stabilizing ability for ultraviolet light, thus endowing the epoxy film with excellent UV aging resistance; on the other hand, it contains terminal amino groups that can participate in complex cross-linking reactions and increase the cross-linking density of the epoxy film, thereby overcoming the problem of precipitation and migration of small molecule anti-UV components under harsh environments.

The application provides an anti-coagulation protein Triabin containing a tyrosine sulfation modification and a semi-chemical synthesis method thereof. According to the distance, the Triabin is divided into fragment 1 and fragment 2 according to the closest cysteine to a sulfated tyrosine site, the sulfated tyrosine site is located in the fragment 1, and the sulfated tyrosine site is close to the C-terminal of the fragment 1; the polypeptide solid-phase synthesis technology is used to synthesize a fragment 1 polypeptide resin, and after cleavage, deprotection, extraction and purification, the fragment 1 with an amide C-terminal is obtained; the E. coli recombinant expression technology is used to obtain the fragment 2 with a hydrazine C-terminal; the thioester of the fragment 2 with the hydrazine C-terminal is converted, the natural chemical linking reaction and the neopentyl removal reaction are used to obtain a full-length linear protein, and the anti-coagulation protein Triabin containing the tyrosine sulfation modification is obtained through a refolding reaction. The anti-coagulation protein Triabin containing the tyrosine sulfation modification has stronger anti-coagulation activity than the wild-type Triabin.

This invention belongs to the field of polymer materials and relates to a method for preparing a multifunctional emulsion antioxidant and its application, specifically to an emulsion antioxidant that also absorbs ultraviolet light and its application. A multifunctional emulsion-type antioxidant comprises the following components: a phenolic primary antioxidant, wherein the phenolic primary antioxidant comprises a mixture of p-cresol and dicyclopentadiene copolymer (TH-CPL) and triethylene glycol bis[β-(3-tert-butyl-4-hydroxy-5-methylphenyl)propionate] (antioxidant 245); a thioester secondary antioxidant; a UV absorber; a light stabilizer; a nonionic surfactant; and deionized water; wherein the UV absorber is N-(ethoxycarbonylphenyl)-N'-methyl-N'-phenylformamidinium (UV-1), and the light stabilizer is a mixture of bis(1,2,2,6,6-pentamethyl-4-piperidine) sebacate and 1-methyl-8-(1,2,2,6,6-pentamethyl-4-piperidine) sebacate (292).

The present invention relates to novel aminothiol ester compounds or their pharmaceutically acceptable salts or optical isomers, racemates, diastereoisomers, enantiomers or tautomers. The present invention also relates to the process for preparing and to these compounds for use as a medicament, in particular for the treatment or prevention of cancer. Furthermore, the present invention relates to an antibody-drug conjugate comprising these compounds.

The invention relates to an acyl transfer reagent and a preparation method of an amide compound, and belongs to the field of organic synthesis in organic chemistry. Polyfluoro-substituted aromatic hydrocarbon, acyl chloride and a sulfur transfer reagent are adopted as raw materials, polyfluoro aryl thioester is obtained through two continuous electrophilic substitution reactions, and then further application research proves that the compound is an efficient acyl transfer reagent and can be used for acylation reactions of various amines. The route and reaction conditions adopted in the method are green, environment-friendly, simple and mild, the raw materials are easy to obtain, the product selectivity is high, the variety is rich, and the method is expected to be further applied to industrial production.

In one aspect, the disclosure relates to charge-shifting polymers including a polymeric backbone, one or more tertiary amine-containing pendant groups, and at least one linker between the polymeric backbone and each of the one or more pendant groups, wherein the at least one linker comprises a thioester. Also disclosed are methods of making the same, compositions comprising the charge-shifting polymers and at least one therapeutic molecule, and methods of controlled intracellular release of therapeutic molecules including, but not limited to, small molecules, peptides and proteins, and nucleic acids using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

The application discloses a kind of anticorrosive easy-to-clean coatings for concrete structure, its preparation method and application method, belong to road anticorrosive coating production field.Anticorrosive easy-to-clean coatings are made of specific proportion water, water-based self-crosslinking emulsion, film forming aid, fumed silica, dispersing agent, hydrophobic modifier, wherein, the hydrophobic modifier is made by active polymerization reaction by fluorine-containing monomer, initiator, thioester chain transfer agent and hydrophilic monomer.Compared with prior art, the anticorrosive easy-to-clean coatings for concrete structure of the application has good easy-to-clean capacity while maintaining good durability, adhesion, and has good popularization and application value.

Provided herein are cleavable peptides, cleavable peptide-based linkers, and compounds or conjugates containing the same, comprising an enzyme substrate peptide adjacent to a self- immolative dipeptide. The self-immolative dipeptides described herein can be bonded to a payload (e.g., a drug) via an ester or thioester bond, enabling traceless release of the payload following enzymatic cleavage of the substrate. Also provided herein are methods and compositions for using and producing the compounds and conjugates described herein, for example, for treating cancers.

A capsule having: a capsule shell having a capsule-shell composition; the capsule shell having at least one interior surface and at least one exterior surface; the at least one interior surface being a boundary of a first cavity within the capsule; the first cavity having a first-cavity total volume of space; a polymer-additive fill composition that occupies a portion of the first-cavity total volume of space; the polymer-additive fill composition including a polymer additive that is: a phosphite, a monophosphite, a hindered phenolic antioxidant, a hindered amine light stabilizer, a UV absorber, an antiblocking agent, a thioester, an antistatic agent, a slip agent, a fire retardant, a nucleating agent, an impact modifier, a blowing agent, a plasticizer, or a polymer processing aid; and the polymer-additive fill composition being a different composition than the capsule-shell composition.

This invention provides a method for preparing thioester compounds, comprising: (1) mixing sulfur-containing reactants with a propylene solvent, dissolving them to obtain a mixed organic solution; and (2) conveying the mixed organic solution obtained in step (1) to a microchannel reactor for a continuous flow rearrangement reaction to obtain the thioester compounds. The production method provided by this invention is safe and controllable, enabling continuous production, reducing environmental pollution from byproducts, and requiring less space in the reaction equipment. Furthermore, by using a propylene solvent with a high flash point and high boiling point, this invention can reduce the pressure load on the reaction equipment during the high-temperature continuous flow rearrangement reaction, thereby lowering the pressure level of the chemical reaction and improving safety.

A capsule having: a capsule shell having a capsule-shell composition; the capsule shell having at least one interior surface and at least one exterior surface; the at least one interior surface being a boundary of a first cavity within the capsule; the first cavity having a first-cavity total volume of space; a polymer-additive fill composition that occupies a portion of the first-cavity total volume of space; the polymer-additive fill composition including a polymer additive that is: a phosphite, a monophosphite, a hindered phenolic antioxidant, a hindered amine light stabilizer, a UV absorber, an antiblocking agent, a thioester, an antistatic agent, a slip agent, a fire retardant, a nucleating agent, an impact modifier, a blowing agent, a plasticizer, or a polymer processing aid; and the polymer-additive fill composition being a different composition than the capsule-shell composition.

The invention belongs to the technical field of hot melt adhesives, and particularly relates to a depolymerizable polyurethane hot melt adhesive as well as a preparation method and application thereof, and the depolymerizable polyurethane hot melt adhesive comprises the following raw materials in parts by mass: 30-70 parts of polymer polyol; 1-15 parts of a chain extender containing a dihydroxy thioester structure; 10 to 30 parts of polyisocyanate; and 0.05-1 part of an auxiliary agent. The polyurethane hot melt adhesive disclosed by the invention not only has excellent multi-substrate bonding performance and environmental aging stability, but also can realize controllable degradation under the condition of not needing high temperature or special equipment, so that the convenience of reworking repair and green circulation is remarkably improved, and the problem that electronic parts are difficult to recycle is solved.

This invention provides a flame-retardant polyolefin composition, its preparation method, and its application. By weight, the flame-retardant polyolefin composition comprises 13-22 parts of ethylene-vinyl acetate copolymer, 1.5-8.5 parts of linear low-density polyethylene, 8-17 parts of polyolefin elastomer, 35-55 parts of flame retardant, and 0.5-2.5 parts of antioxidant. The antioxidant includes a primary antioxidant and a secondary antioxidant. The primary antioxidant includes hindered phenolic antioxidants and amine antioxidants; the secondary antioxidant includes thioester antioxidants and / or phosphite antioxidants. In this invention, the flame-retardant polyolefin composition uses ethylene-vinyl acetate copolymer, linear low-density polyethylene, and polyolefin elastomer in specific proportions, combined with an antioxidant of a specific composition, resulting in good heat resistance, aging resistance, and exudation resistance, while also possessing good mechanical properties.

The invention relates to the technical field of cyclopeptide drug synthesis, in particular to a method for synthesizing mirror cyclopeptide by using OaAEP1 enzyme under the assistance of thioester, which comprises the following steps: firstly, synthesizing a linear mirror cyclopeptide thioester precursor by using an N-fluorenylmethoxycarbonyl (Fmoc) solid-phase polypeptide synthesis method, and then generating the mirror cyclopeptide from the thioester precursor under the mediation of the OaAEP1 enzyme. According to the invention, the mirror image ring melittin (D-cMelittin) is synthesized by using OaAEP1 enzyme under the assistance of thioester for the first time, and the mirror image ring melittin (D-cMelittin) has high protease stability and good antibacterial activity.

The present application relates to the technical field of lubricating grease, in particular to a lubricating grease composition for angle grinder and a preparation method thereof. The present application provides a lubricating grease composition for angle grinder, which comprises base oil, thickening agent and additive, wherein the additive comprises extreme pressure anti-wear agent, and the extreme pressure anti-wear agent comprises molybdenum-containing extreme pressure anti-wear agent, amino thioester extreme pressure anti-wear agent and zinc thiophosphate salt extreme pressure anti-wear agent with a mass ratio of (1.5-4):(0.5-2):(1-3). The present application effectively reduces the wear of gears when used in angle grinder through the selection and specific compounding of extreme pressure anti-wear agent, and at the same time can prolong the service life of angle grinder, meeting the lubrication requirements of angle grinder gears. The present application is matched with suitable base oil and thickening agent system, and the obtained lubricating grease composition can play excellent adhesion performance under high speed working conditions of angle grinder, reducing the risk of grease leakage of angle grinder while ensuring lubricity.

The present invention relates to a method for the enzymatic synthesis of (oligo)peptides comprising coupling (a) a (oligo)peptide C-terminal ester or thioester and (b) a (oligo)peptide nucleophile having an N-terminal unprotected amine, wherein the coupling is performed in a fluid comprising water, and wherein the coupling is catalyzed by a subtilisin BPN' variant or a homologue thereof comprising the following mutations compared to subtilisin BPN' as set forth in SEQUENCE ID NO: 2: deletion of the amino acids corresponding to positions 75-83; a mutation at the amino acid position corresponding to S221 which is S221C or S221 selenocysteine; preferably a mutation at the amino acid position corresponding to P225, wherein the amino acid positions are defined according to the sequence of subtilisin BPN' as set forth in SEQUENCE ID NO: 2. In addition, the present invention relates to enzymes suitable for use as catalysts in the method of the present invention.

Thioesters, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides; and a chemoselective and site-specific functionalization protocol of protected thiocarbazates and semithiocarbazates are described. The protocol features the use of Mitsunobu reaction to alkylate specifically the nitrogen atom close to the acylthiol moiety with alcohols to produce protected mono-substituted thiocarbazates that can be stored for months, activated under mild conditions at low temperature using halonium reagents and integrated orthogonally to make substituted semicarbazides that can be used, e.g., as synthons in synthesis of aza-amino acid conjugates, azapeptides and other peptidomimetics. Methods for preparing and using ureases, carbazides, semicarbazides, beta-peptides, azapeptides, and other peptidomimetics and azapeptide conjugates, and uses of ureases, carbazides, semicarbazides, beta-peptides, azapeptides in drug discovery, diagnosis, inhibition, prevention and treatment of diseases are also described.

The application belongs to the field of computational theoretical chemistry, and discloses a method for rapidly predicting natural chemical connection reaction rate by using a machine learning model.The method comprises the following steps: firstly, synthesizing a series of peptide thioesters containing different thioester groups to construct a peptide thioester library; then, determining the natural chemical connection reaction rates of different peptide thioesters as sample labels; subsequently, analyzing the influence of structure on the reaction rate of the peptide thioester through quantum structure optimization to obtain the feature descriptor of each sample from the calculation simulation; finally, based on the feature descriptor and the sample label, a formula of structure-function relationship is summarized by using a computer learning algorithm, so that the influence of the structure of the peptide thioester on the natural chemical connection reaction rate can be rapidly predicted.The method greatly improves the work efficiency, the result is accurate, the reproducibility is good, and the method is convenient to popularize and apply.

The present application relates to the technical field of cyclic peptide drug synthesis, and particularly relates to a method for synthesizing mirror image cyclic peptide by using OaAEP1 enzyme with the assistance of thioester, which comprises the following steps: firstly, a linear thioester precursor of mirror image cyclic peptide is synthesized by using an N-fluorenylmethyloxy carbonyl (Fmoc) solid-phase polypeptide synthesis method; and then the thioester precursor can generate the mirror image cyclic peptide under the mediation of OaAEP1 enzyme. The present application first synthesizes mirror image melittin (D-cMelittin) by using OaAEP1 enzyme with the assistance of thioester, and the mirror image melittin has high protease stability and good antibacterial activity.

This invention provides a method for preparing a composite all-solid polymer electrolyte for wind power energy storage, belonging to the field of lithium-ion battery energy storage technology. It can at least partially solve the existing problems of difficulty in balancing room temperature ion conductivity and processing performance, poor solid-solid interface contact, high interface impedance, insufficient high-voltage long-cycle stability, and incompatibility between high-voltage tolerance and flame-retardant safety performance. This invention achieves self-repair of the electrolyte interface through room temperature reversible bonding of dynamic thioester bonds. With the three-in-one multifunctional AFSI monomer, a dense LiF-rich CEI film is formed on the positive electrode surface. Combined with the gradient structure design of enriching high-voltage resistant components on the positive electrode side, the interface oxidation and decomposition under high voltage is suppressed from the root. The core-shell structure LLZTO@PDA-FAS filler is used to break through the bottleneck of wide temperature range high ion conductivity, completely eliminate the space charge layer effect of inorganic-organic interface, and construct a continuous lithium-ion transport network. Moreover, the one-step in-situ gradient polymerization process results in low preparation cost.

This invention relates to the field of rubber materials technology, and provides a tire tread compound composition and its preparation method. The tire tread compound composition comprises, by weight parts: 100 parts rubber matrix; 15-25 parts modified recycled tire rubber powder; 5-10 parts reversible crosslinking agent; 2.5-3.3 parts vulcanization system; and 73-100 parts rubber additives. The modified recycled tire rubber powder is prepared by introducing oxygen-containing polar groups onto the surface of recycled tire rubber powder, followed by in-situ grafting with a mixture of mercaptosilane and thioester silane. The reversible crosslinking agent is polybutadiene with end groups linked to aromatic disulfide bonds via urea bonds, urethane bonds, or amide bonds. The rubber additives include 60-80 parts silica, 8-12 parts silane coupling agent, and 5-8 parts bio-based hydrocarbon resin. By introducing a reversible crosslinking agent and modifying recycled tire rubber powder, a dual crosslinking network is synergistically constructed, achieving high-value utilization of waste resources while endowing the tire tread compound with excellent comprehensive properties.