144 results about "Thioester" patented technology

The invention discloses a mercury ion detection fluorescent probe based on quinoline as well as a preparation method and application of the mercury ion detection fluorescent probe. The fluorescent probe and a structural formula of the fluorescent probe are shown as a formula I in the specification. A quinoline derivative, namely 2-methyl-7-hydroxyquinoline, is used as a fluorescent chromophore, a thioester group is used as a recognition group, and the prepared fluorescent probe shows high sensitivity and high selectivity on Hg < 2 + > in a solution. The preparation method of the fluorescent probe is simple in steps, raw materials are easy to obtain, and the obtained product is a white flocculent solid, is easy to store, has a wide application prospect and can be produced and applied on a large scale.

The invention discloses an oxidation-resistant monomer casting nylon material and a preparation method thereof, and relates to the field of material preparation, and the monomer casting nylon material is applied to a high-temperature and oxygen-enriched environment and comprises the following components in parts by mass: 100 parts of caprolactam; 0.1-0.3 part of a catalyst which is one of sodium hydroxide, potassium hydroxide or lithium hydroxide; 0.5 to 1.5 parts of an activating agent, wherein the activating agent is N-acetyl caprolactam; 0.7 to 3 parts of a main antioxidant, wherein the main antioxidant comprises a hindered phenol antioxidant and a thioester antioxidant; 0.1-0.5 part of an auxiliary antioxidant, which is a metal deactivator; 1-3 parts of an inorganic filler which is modified montmorillonite; and 0.5-2 parts of a hydrophobic agent which is a silane coupling agent. By constructing a composite anti-oxidation system, multi-level synergistic protection can be formed for three key oxidation stages of free radical initiation, peroxide accumulation and metal catalysis, and a full path of an oxidation chain reaction is covered from a molecular level, so that the aging process of the material is remarkably delayed, and the service life of the material is prolonged. And high oxygen resistance and relatively long service life are provided for nylon application under severe working conditions.

The invention relates to a cable sheath material, and particularly discloses a weather-proof low-smoke halogen-free flame-retardant polyolefin cable sheath material and a preparation method thereof. The cable sheath material is prepared from 30 to 45 parts of low-density polyethylene, 10 to 30 parts of high-impact homo-polypropylene, 15 to 30 parts of graft modified flexibilizer, 30 to 50 parts of main flame retardant, 1 to 5 parts of coupling agent, 10 to 30 parts of phosphorus-nitrogen synergistic flame retardant, 4 to 10 parts of efficient smoke suppressant, 0.2 to 0.8 part of hindered phenol main antioxidant, 0.4 to 1.2 parts of thioester auxiliary antioxidant, 0.4 to 1.0 part of hindered amine light stabilizer, 0.5 to 1.5 parts of ultraviolet light absorber and 2.5 to 2.5 parts of weather resistance enhancer. 5.0 parts of a lubricant, 0.5 to 2.0 parts of a lubricant, and 0.1 to 0.8 part of an anti-copper agent. The mechanical property, the electrical insulation property and the weather resistance of the sheath material are effectively improved, an efficient synergistic flame retardant effect can be obtained, the flame retardant property is excellent, and a finished product can obtain excellent weather resistance, low-smoke zero-halogen property, flame retardant property, mechanical property, electrical insulation property and the like.

This invention discloses a high-transmittance insulating ink for back-contact batteries and its preparation method, belonging to the technical field of insulating inks. The insulating ink comprises the following components by mass percentage: 60%~64% base resin, 1%~2% thiol, 2%~4% tackifier, and 25%~30% diluent; wherein the base resin is a hydroxyl-terminated polyester-modified acrylate, the thiol is ethylene dithiol, the tackifier is at least one of terpene resin, C5 petroleum resin, and C9 petroleum resin, and the diluent is at least one of 1,4-butanediol diacrylate, pentaerythritol triacrylate, and dipropylene glycol diacrylate. This invention utilizes the reaction of the dithiol's dithiol group with the hydroxyl groups (-OH) or double bonds in the hydroxyl-terminated polyester-modified acrylate to form thioether bonds (-S-) or thioester bonds, constructing a three-dimensional cross-linked network, thereby significantly improving the hardness and transmittance of the cured resin system. The reasonable combination of tackifier and diluent allows the ink to achieve high adhesion while maintaining hardness.

The invention belongs to the technical field of coupling reagents, and particularly discloses application of N-sulfonyl imidazolium salt as a coupling reagent, and the N-sulfonyl imidazolium salt as the coupling reagent is applied to synthesis of amide, dipeptide, polypeptide, carboxylic ester, carboxylic thioester, phosphamide and phosphate. According to the application of the N-sulfonyl imidazolium salt as the coupling reagent, compared with the prior art, the dosage of the coupling reagent is greatly reduced, the generation of byproducts is reduced, and the conversion rate of reactants is improved.

The invention provides an olefin hydrocarbonylation method which comprises the following step: olefin as shown in a formula (1), a nucleophilic reagent as shown in a formula (2) and carbon monoxide are subjected to a hydrocarbonylation reaction under the action of a metal catalyst, a ligand, protonic acid and optional iodide under the condition of illumination. According to the present invention, olefin represented by a formula (1), a nucleophilic reagent represented by a formula (2) and carbon monoxide are adopted as raw materials, and under the action of a metal catalyst, a ligand, a protonic acid and an optional iodide, a hydrocarbonylation reaction is performed under the illumination condition so as to obtain carboxylic acid / ester / amide / thioester and other products; the method provided by the invention can be realized at normal temperature and normal pressure, does not need special equipment, has low potential safety hazard and low energy consumption, greatly reduces the cost of large-scale production of carboxylic acid / ester / amide / thioester, and provides a novel green and efficient synthesis process for industrial production of carboxylic acid / ester / amide / thioester.

Provided is a method for producing a carbonyl compound using light energy, the method being characterized by irradiating a substrate with light having a wavelength of 200-420 nm in the presence of a tetrahalomethane to react the substrate. The method, which is for producing a carbonyl compound, e.g., an ester, a lactone, a carboxylic acid, an amide, a thioester, or a ketone, makes it possible to obtain the carbonyl compound directly from a substrate without using a heavy metal or the like in a stoichiometric amount.

The present invention discloses a one-step method for preparing fluoromethyl thioester compounds from aromatic olefins. Under heating conditions, the aromatic olefin compounds are used as starting materials, fluoromethyl thiobenzenesulfonate is used as a fluoromethylthiolation reagent, and an oxidant, a catalyst, and an organic solvent are added for reaction to obtain the fluoromethyl thioester compounds. The method of the present invention uses inexpensive and readily available aromatic olefin compounds as starting materials, fluoromethyl thiobenzenesulfonate is used as a fluoromethylthiolation reagent that is stable at room temperature, a mild peroxide compound as an oxidant, a copper salt as a catalyst, and acetonitrile as a solvent. The corresponding fluoromethyl thioester compounds are obtained by heating the reaction in air for a certain period of time. This synthetic method features mild conditions, simple operation, environmental friendliness, a wide range of substrate applicability, and good functional group tolerance. Most importantly, it represents the first development of a new pathway for the direct synthesis of fluoromethyl thioesters from aromatic olefins.

The invention discloses a stabilizer for a transparent PVC (Polyvinyl Chloride) product with good gamma-ray irradiation resistance. Comprising the following components in parts by weight: 10-20 parts of benzoic acid organic calcium salt, 10-20 parts of benzoic acid organic zinc salt, 10-20 parts of benzoic acid organic magnesium salt, 10-20 parts of benzoic acid organic aluminum salt, 20-30 parts of hydrotalcite, 5-10 parts of borate, 3-10 parts of a pyrimidine auxiliary color retention agent, 3-10 parts of a hindered amine light stabilizer and 5-10 parts of a thioester antioxidant. The hindered amine light stabilizer is a light stabilizer with a hindered amine methyl piperidine structure. The transparent PVC product added with the stabilizer has excellent gamma-ray irradiation resistance, and after the irradiation dose is 25kGy, the yellowness index YI of the transparent PVC product is less than 5.0, which indicates that the transparent PVC product added with the stabilizer does not change color in later application and storage processes after gamma-ray irradiation; the transparency is kept well, the light transmittance after irradiation is greater than 85%, and the transparency requirements of medical and food packaging are met; the mechanical property is well maintained, and the tensile strength retention rate after irradiation is greater than 90%.

The present disclosure provides extruded or spun semi-permeable porous hollow fibers comprising covalent ester, thioester, and / or amide cross-linked polypeptides and methods of producing the same. The hollow fibers may be produced from proteins, protein extracts and / or protein isolates derived from plants, animals, bacteria, algae, archaea and / or fungi and, in certain embodiments, are intended to be suitable for human and / or animal ingestion. In some embodiments, the hollow fibers may be designed for producing cartridges compatible with existing and / or novel bioreactor platforms for containing cell cultures in cultured meat production.

The present application relates to a composite stabilizer of 2-bromo-3,3,3-trifluoropropene and its use method, the composite stabilizer comprises: a phenolic compound, a phosphite or thioester compound, an acid binding agent, the molar ratio of the amount of the three substances is 1:0.1~6:0.1~6, and the mass ratio of the amount and 2-bromo-3,3,3-trifluoropropene is 0.001~1.0:100. Through the interaction between the above stabilizer components, the rectification process of the product can effectively inhibit the deterioration problems such as the increase of acid value, the color change to yellow and the decrease of purity of 2-bromo-3,3,3-trifluoropropene, provide excellent long-term stability, facilitate its production, transportation and storage, and ensure its smooth application in the field of new fire extinguishing agent, organic synthesis and the like.

The disclosure describes poly(β-thioester) polymers and polymeric nanoparticles, pharmaceutical compositions comprising these materials, their use in the treatment of cancer and infectious disease, and machine learning methods for identifying and selecting them.

The present application provides an extractant and a method for purifying copper-containing cyanide wastewater, belonging to the technical field of wastewater purification. The extractant uses an imidazole ring as the molecular backbone, and through a quaternization reaction, aliphatic chain functional groups are introduced to adjust the hydrophobic property of the extractant, ensuring that the extractant is insoluble in the inorganic aqueous phase. By derivatizing the amino group to form a thioester group, the terminal mercapto group hydrolyzes under alkaline conditions to form an S- activation site, which can effectively bond with cuprous ions (Ⅰ). At the same time, the S- activation site and the lone pair electrons on the adjacent N atom cooperate with each other to chelate cuprous ions (Ⅰ) to the greatest extent, ensuring that the cuprous ions exist in the form of chelates and will not be further converted into the free state. In addition, the lone pair electrons on the N atom and the carboxyl group can cooperate with each other to achieve targeted chelation of cupric ions (Ⅱ) in the solution. The present application realizes the efficient extraction of copper in the cyanide-containing wastewater, achieving the purpose of purifying the copper-containing cyanide wastewater.

The invention relates to aminoethyl thioesters of saturated carboxylic acids, of a short chain acid, and a bile acid, therapeutic compositions containing such aminoethyl thioesters, and a method of improving the health of an animal or of treating of ameliorating a health disorders in an animal by administering to the animal an effective amount of a therapeutic composition comprising an inventive aminoethyl thioester of a carboxylic acid.

The application discloses a synthesis method of a thioester functionalized 2-oxoindole, and belongs to the technical field of organic synthesis. The method is to use an iodine acetyl aniline derivative and a thioester as raw materials, to add a base and a solvent under the action of a palladium catalyst and a ligand, to perform one-pot reaction, and to synthesize a series of thioester functionalized 2-oxoindole compounds at a temperature of 70-100 DEG C. The reaction avoids directly using toxic CO gas or a strong stimulating gas smell aryl thio phenol or thiol and other substances, and has the advantages of mild reaction condition, simple operation, strong substrate universality, easy availability of raw materials, high yield, easy separation of target products and the like.

A process for preparing preferably degradable copolymers by free radical ring-opening polymerization using thionolactone monomers or thionocarbonate monomers, in the presence of a radical polymerization initiator. Also, the copolymers, which include thioester or thiocarbonate bonds, that are obtained by carrying out the process including the free radical ring-opening polymerization using thionolactone monomers or thionocarbonate monomers.

This invention provides a high-transmittance, yellowing-resistant epoxy resin film and its preparation method. The epoxy resin film comprises the following raw materials in parts by weight: 30-35 parts liquid epoxy resin, 25-35 parts solid epoxy resin, 20-30 parts toughening agent, 5-8 parts aromatic diamine curing agent, 3-5 parts terminal amino triazine / Schiff base curing agent as shown in Formula I, 0.3-0.5 parts accelerator, 1-2 parts coupling agent, 0.1-0.3 parts defoamer, 0.5-0.8 parts thioester antioxidant, and 50-100 parts solvent. The curing agent as shown in Formula I, on the one hand, contains Schiff base bonds (C=N) and triazine ring structures with strong absorption and stabilizing ability for ultraviolet light, thus endowing the epoxy film with excellent UV aging resistance; on the other hand, it contains terminal amino groups that can participate in complex cross-linking reactions and increase the cross-linking density of the epoxy film, thereby overcoming the problem of precipitation and migration of small molecule anti-UV components under harsh environments.

The application provides an anti-coagulation protein Triabin containing a tyrosine sulfation modification and a semi-chemical synthesis method thereof. According to the distance, the Triabin is divided into fragment 1 and fragment 2 according to the closest cysteine to a sulfated tyrosine site, the sulfated tyrosine site is located in the fragment 1, and the sulfated tyrosine site is close to the C-terminal of the fragment 1; the polypeptide solid-phase synthesis technology is used to synthesize a fragment 1 polypeptide resin, and after cleavage, deprotection, extraction and purification, the fragment 1 with an amide C-terminal is obtained; the E. coli recombinant expression technology is used to obtain the fragment 2 with a hydrazine C-terminal; the thioester of the fragment 2 with the hydrazine C-terminal is converted, the natural chemical linking reaction and the neopentyl removal reaction are used to obtain a full-length linear protein, and the anti-coagulation protein Triabin containing the tyrosine sulfation modification is obtained through a refolding reaction. The anti-coagulation protein Triabin containing the tyrosine sulfation modification has stronger anti-coagulation activity than the wild-type Triabin.

This invention belongs to the field of polymer materials and relates to a method for preparing a multifunctional emulsion antioxidant and its application, specifically to an emulsion antioxidant that also absorbs ultraviolet light and its application. A multifunctional emulsion-type antioxidant comprises the following components: a phenolic primary antioxidant, wherein the phenolic primary antioxidant comprises a mixture of p-cresol and dicyclopentadiene copolymer (TH-CPL) and triethylene glycol bis[β-(3-tert-butyl-4-hydroxy-5-methylphenyl)propionate] (antioxidant 245); a thioester secondary antioxidant; a UV absorber; a light stabilizer; a nonionic surfactant; and deionized water; wherein the UV absorber is N-(ethoxycarbonylphenyl)-N'-methyl-N'-phenylformamidinium (UV-1), and the light stabilizer is a mixture of bis(1,2,2,6,6-pentamethyl-4-piperidine) sebacate and 1-methyl-8-(1,2,2,6,6-pentamethyl-4-piperidine) sebacate (292).

The present invention relates to novel aminothiol ester compounds or their pharmaceutically acceptable salts or optical isomers, racemates, diastereoisomers, enantiomers or tautomers. The present invention also relates to the process for preparing and to these compounds for use as a medicament, in particular for the treatment or prevention of cancer. Furthermore, the present invention relates to an antibody-drug conjugate comprising these compounds.

The invention relates to an acyl transfer reagent and a preparation method of an amide compound, and belongs to the field of organic synthesis in organic chemistry. Polyfluoro-substituted aromatic hydrocarbon, acyl chloride and a sulfur transfer reagent are adopted as raw materials, polyfluoro aryl thioester is obtained through two continuous electrophilic substitution reactions, and then further application research proves that the compound is an efficient acyl transfer reagent and can be used for acylation reactions of various amines. The route and reaction conditions adopted in the method are green, environment-friendly, simple and mild, the raw materials are easy to obtain, the product selectivity is high, the variety is rich, and the method is expected to be further applied to industrial production.

According to the electron-rich aryl substituted thioester carbon dioxide absorbent, electron-rich aryl substituted thioester is introduced, so that the prepared carbon dioxide composite absorbent has high carbon dioxide absorption rate and high carbon dioxide desorption rate, and meanwhile, the carbon dioxide desorption temperature is reduced; the defects that a single ethanolamine absorbent is small in absorption capacity and difficult to desorb are overcome.

The invention discloses high-light-transmittance insulating ink for a back contact battery and a preparation method of the high-light-transmittance insulating ink, and belongs to the technical field of insulating ink, the insulating ink comprises the following components in percentage by mass: 60%-64% of matrix resin, 1%-2% of mercaptan, 2%-4% of a tackifier and 25%-30% of a diluent, wherein the matrix resin is hydroxyl-terminated polyester modified acrylate, the thiol is ethanedithiol, the tackifier is at least one of terpene resin, C5 petroleum resin and C9 petroleum resin, and the diluent is at least one of 1, 4-butanediol diacrylate, pentaerythritol triacrylate and dipropylene glycol diacrylate. Disulfydryl of mercaptan reacts with hydroxyl (-OH) or double bonds in hydroxyl-terminated polyester modified acrylate to form thioether bonds (-S-) or thioester bonds, and a three-dimensional cross-linked network is constructed, so that the hardness and light transmittance of a cured resin system are remarkably improved. The reasonable compounding of the tackifier and the diluent is adopted, so that the ink can obtain high adhesive force while keeping the hardness.

In one aspect, the disclosure relates to charge-shifting polymers including a polymeric backbone, one or more tertiary amine-containing pendant groups, and at least one linker between the polymeric backbone and each of the one or more pendant groups, wherein the at least one linker comprises a thioester. Also disclosed are methods of making the same, compositions comprising the charge-shifting polymers and at least one therapeutic molecule, and methods of controlled intracellular release of therapeutic molecules including, but not limited to, small molecules, peptides and proteins, and nucleic acids using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hedgehog (Hh) signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.

The application discloses a kind of anticorrosive easy-to-clean coatings for concrete structure, its preparation method and application method, belong to road anticorrosive coating production field.Anticorrosive easy-to-clean coatings are made of specific proportion water, water-based self-crosslinking emulsion, film forming aid, fumed silica, dispersing agent, hydrophobic modifier, wherein, the hydrophobic modifier is made by active polymerization reaction by fluorine-containing monomer, initiator, thioester chain transfer agent and hydrophilic monomer.Compared with prior art, the anticorrosive easy-to-clean coatings for concrete structure of the application has good easy-to-clean capacity while maintaining good durability, adhesion, and has good popularization and application value.

The present invention discloses a method for carbonylation to prepare α,β-unsaturated thioester compounds, which comprises the following steps: reacting tris(dibenzylideneacetone)dipalladium, 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene, potassium hydrogen phosphate, alkenyl trifluoromethanesulfonate and aryl thiophenol formate at 30 °C for 20 hours. After the reaction is complete, the α,β-unsaturated thioester compounds are obtained through post-treatment. The starting materials of this preparation method are cheap and easily available, the operation is simple, and the reaction efficiency is high. Using aryl thiophenol formate as both a carbonyl source and a sulfur source, a variety of α,β-unsaturated thioester compounds can be synthesized according to actual needs. The substrate functional group tolerance range is wide, which not only facilitates the operation but also broadens the practicability of this method.

Provided herein are cleavable peptides, cleavable peptide-based linkers, and compounds or conjugates containing the same, comprising an enzyme substrate peptide adjacent to a self- immolative dipeptide. The self-immolative dipeptides described herein can be bonded to a payload (e.g., a drug) via an ester or thioester bond, enabling traceless release of the payload following enzymatic cleavage of the substrate. Also provided herein are methods and compositions for using and producing the compounds and conjugates described herein, for example, for treating cancers.

A capsule having: a capsule shell having a capsule-shell composition; the capsule shell having at least one interior surface and at least one exterior surface; the at least one interior surface being a boundary of a first cavity within the capsule; the first cavity having a first-cavity total volume of space; a polymer-additive fill composition that occupies a portion of the first-cavity total volume of space; the polymer-additive fill composition including a polymer additive that is: a phosphite, a monophosphite, a hindered phenolic antioxidant, a hindered amine light stabilizer, a UV absorber, an antiblocking agent, a thioester, an antistatic agent, a slip agent, a fire retardant, a nucleating agent, an impact modifier, a blowing agent, a plasticizer, or a polymer processing aid; and the polymer-additive fill composition being a different composition than the capsule-shell composition.

The invention relates to a process for synthesizing a copolymer comprising the step of polymerizing a monomer mixture, comprising: a cyclic comonomer selected from the list comprising lactones, lactams, cyclic amines, cyclic esters or mixtures thereof; and, a compound according to Structure I: wherein R1 is an hydrogen or an alkyl having 1 to 6 carbon atoms; and, wherein R2 and R3 is each independently hydrogen or an alkyl, cycloalkyl, aralkyl, aryl, alkynyl, cycloalkenyl; or, wherein R2 and R3 together with the atom to which they are attached form a saturated or unsaturated 3-, 4-, 5-, 6-, or 7-membered ring, which may be substituted. The invention relates further to the copolymer obtained in the process and to the use of compound according to structure (I) to accelerate biodegradability.