13 results about "Hydroxybenzoate" patented technology

The application provides a white-borneol apricot kernel face mask liquid and a preparation method and application thereof, and relates to the technical field of cosmetics. The preparation raw materials of the white-borneol apricot kernel face mask liquid provided by the application include white petrolatum 5-20 parts, mono-diglyceride 1-10 parts, methyl p-hydroxybenzoate 0.01-8 parts, glycerol 1-10 parts, butanediol 0.05-10 parts, Tween-80 0.05-12 parts and compound extraction liquid 10-30 parts in terms of weight percentage. The white-borneol apricot kernel face mask liquid provided by the application has good moisturizing effect, is cold and heat resistant, has good stability and meets the microbial detection standard of cosmetics.

The invention belongs to the technical field of polymer functional aids, and discloses a layered composite metal hydroxide and a preparation method and application thereof, the chemical expression of the layered composite metal hydroxide is M < 2 + > 1-xM < 3 + > x (OH) 2 (A < n->) x / n.mH < 2 > O (at) P, m < 2 + > is selected from any one or two of Mg < 2 + >, Zn < 2 + >, Ni < 2 + >, Ca < 2 + >, Fe < 2 + > and Cu < 2 + >; m < 3 + > is selected from any one or two of Al < 3 + >, Co < 3 + >, Ti < 3 + >, Fe < 3 + > and Cr < 3 + >; a < n-> is selected from the group consisting of beta-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionate, 3, 5-di-tert-butyl-4-hydroxybenzoic acid or beta-(3-tert-butyl-4-hydroxy-5-methylphenyl) propionate; x ranges from 0.1 to 0.5; n is 1 or 2; m ranges from 0.4 to 1.5; p is selected from chitosan, chitin, polyglucosamine, polyallylamine or polyethylene polyamine; based on the total weight of the layered composite metal hydroxide, the content of P is 5-15 wt%. The layered composite metal hydroxide provided by the invention has excellent migration resistance when being used as a polymer antioxidant.

The utility model discloses a sodium methyl p-hydroxybenzoate drying machine which comprises a machine body, and a power assembly is arranged on one side of the machine body. A filter plate is arranged in the screening box, and the filter plate is inclined; the hole area on the filter plate can be adjusted; the side face, close to the lower end of the filter plate, of the screening box is provided with a discharging channel. The upper end of the crushing box is communicated with the discharging channel; the inner space of the crushing box is cylindrical, a blanking port communicated with the machine body is formed in the lower end of the crushing box, and a filter plate II is arranged in the blanking port; and a crushing structure is arranged in the crushing box. Before entering the drying machine, the raw materials are firstly screened, so that the raw materials entering the machine body are all crushed without caking, and the drying effect is improved.

The invention discloses a synthesis method of a benzofuro [3, 2-b] benzofuran compound, and belongs to the technical field of organic synthesis. According to the method, o-hydroxybenzoate compounds or halogenated derivatives thereof and methyl bromoacetate are taken as starting raw materials, and a target product is prepared through five steps of reaction: step 1, cyclization is performed at 0 DEG C to room temperature under an alkaline condition to obtain a benzofuran carboxylate intermediate; 2, sulfonylating by trifluoromethanesulfonic anhydride to obtain a sulfonate intermediate; 3, carrying out an etherification reaction with an o-halogenated phenol compound at the temperature of 80-120 DEG C; 4, hydrolyzing through inorganic strong base to obtain a benzofuran carboxylic acid intermediate; and 5, carrying out intramolecular ring closing at 80-180 DEG C under the action of a palladium catalyst and DBU. The raw materials are cheap and easy to obtain, the reaction selectivity is high, the total yield is stable, the substrate adaptability is wide, efficient synthesis of unilateral and bilateral halogen substituted derivatives of benzofuro [3, 2b] benzofuran compounds is successfully achieved, and the method has remarkable industrial application value.

The invention provides a preparation method of phenyl 4-hydroxybenzoate, which comprises the following steps: step S1, reacting 4-hydroxybenzoic acid with Boc anhydride under the action of Lewis acid to obtain 4-t-butyloxycarbonyloxybenzoic acid; s2, enabling the 4-tert-butyloxycarbonyloxy benzoic acid to react with phenol under the action of a condensation reagent, so as to obtain 4-tert-butyloxycarbonyloxy phenyl benzoate; and S3, carrying out a reaction on the 4-tert-butyloxycarbonyloxy phenyl benzoate under an alkaline condition to remove Boc so as to obtain the 4-hydroxybenzoic acid phenyl ester. According to the preparation method provided by the embodiment of the invention, the reaction condition is mild, the process is green and environment-friendly, the use risk of a chlorination reagent is avoided, and the reaction safety coefficient is improved.

The invention relates to a novel tizanidine salt and a preparation method thereof, and belongs to the technical field of pharmaceutical chemicals. The novel tizanidine salt is obtained by selecting low-corrosivity and weak-acidity organic carboxylic acid as a ligand through a cooling crystallization or solvent evaporation crystallization mode. Wherein the organic carboxylic acid is selected from salicylic acid, p-hydroxybenzoic acid, maleic acid and pimelic acid. The formed tizanidine salicylate is in a P21 / n space group of a monoclinic system; the tizanidine p-hydroxybenzoate is an orthorhombic crystal system and has a Pbcn space group; the alpha crystal form of the tizanidine maleate is a P21 / c space group of a monoclinic system; the beta crystal form of the tizanidine maleate is a P21 / c space group of a monoclinic system; the tizanidine pimelate is an orthorhombic crystal system and has a Pna21 space group. The dissolution rate and the inherent dissolution rate of the tizanidine are improved in a mode of forming salt through crystal engineering, the obtained novel tizanidine salt has good stability, the bioavailability of the tizanidine is improved so that the tizanidine salt can give full play to the curative effect, the preparation condition is mild, the reproducibility is good, and large-scale production is easy to realize.

The invention discloses a method for determining a preservative in a children oral liquid preparation, and belongs to the technical field of detection. Comprising the following steps: preparing a mixed reference substance standard stock solution; preparing a series of standard solutions; the method comprises the following steps: precisely measuring a to-be-measured sample, putting the to-be-measured sample into a measuring flask, diluting the to-be-measured sample to a scale by using an acetonitrile-water solution with a volume ratio of 1: 1, uniformly shaking, and passing through a 0.22 mu m filter membrane to obtain a sample solution for later use; and precisely sucking the series of standard solutions and the sample solution, injecting into a gas chromatograph, and determining. According to the method, whether various preservative components such as p-benzyl alcohol, sorbic acid, benzoic acid, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate and butyl p-hydroxybenzoate exist in the oral liquid preparation for children or not can be determined at the same time through the gas chromatography, and the recovery rate and precision are high. When an acetonitrile aqueous solution with the volume fraction of 50% is selected as an extraction solvent, a sample to be detected can be quickly and uniformly dispersed and dissolved.

The present invention relates to a photovoltaic element, comprising a front layer, a back layer, and a plurality of photovoltaic cells, which photovoltaic cells are present between the front layer and back layer, wherein the front layer consists of a polypropylene composition, comprising: a) a random polypropylene resin; b) a mixture of light stabilizing additives; said mixture comprising: i) a high molecular weight hindered tertiary amine light stabilizer (t-HM-HAL S) having a weight average molecular weight of at least 1600 g / mol; ii) a low molecular weight hindered secondary amine light stabilizer (s-LM-HALS) having a weight average molecular weight of below 1000 g / mol; iii) an ultraviolet synergist, being a n-alkyl-3,5-dialkylated 4-hydroxybenzoate; iv) an ultraviolet absorber, being a hydroxybenzotriazole compound or a hydroxyl benzophenone compound or a mixture thereof; c) a mixture of antioxidant additives; said mixture comprising: i) a phenolic antioxidant; and ii) a phosphite additive. The invention also relates to a polypropylene composition and to the use thereof as front layer.

The invention discloses rhodococcus pyridinivorans LHX-1 and application thereof in degradation of methyl p-hydroxybenzoate, the rhodococcus pyridinivorans LHX-1 has an efficient degradation effect on the methyl p-hydroxybenzoate, pollutants can be completely converted into harmless substances such as CO2 and H2O, and the removal rate of the methyl p-hydroxybenzoate within 100 mg / L is high. The strain has high environmental adaptability, can be used for repairing polluted water and polluted environment, can also be used for purifying waste gas containing methyl p-hydroxybenzoate, and has a wide application prospect in biological purification of industrial waste gas and waste water.

The purpose of the present invention is to provide a method for producing hydroquinone that involves an enzyme that can convert p-hydroxybenzoic acid into hydroquinone at higher efficiencies than the 4-hydroxybenzoate 1-hydroxylase possessed by Candida parapsilosis strain CBS604. This purpose is achieved, for example, by a method for producing hydroquinone, the method comprising a step for obtaining hydroquinone by reacting p-hydroxybenzoic acid with a 4-hydroxybenzoate 1-hydroxylase derived from Spathaspora passalidarum.

The application belongs to the technical field of electric power insulation equipment, and particularly relates to a bird-repellent silicone rubber composite insulator and a preparation method and application thereof. The bird-repellent silicone rubber composite insulator is characterized in that bird-repellent essential oil microcapsules are uniformly distributed in the heat vulcanized silicone rubber of the outer insulation material. The raw materials of the core material of the bird-repellent essential oil microcapsules include, by weight, phenyl o-hydroxybenzoate, grapefruit peel ethanol extract, cinnamon bark ethanol extract, civetone, quercitrin and dibutyl hydroxytoluene. The bird-repellent essential oil microcapsules are added in the silicone rubber mixing process of the existing silicone rubber composite insulator, so that the existing ordinary silicone rubber composite insulator is endowed with good endogenous bird-repellent function, has broad-spectrum repellence, and has long repellence timeliness, which can be more than 10 years.

This invention discloses a preparation process for the ROCK2 immunomodulator and its key intermediate. The invention uses methyl 3-hydroxybenzoate as a raw material to prepare the key intermediate compound E, and then further prepares besudinil and its salt through a substitution reaction of compound E with 5-aminoindazole. The preparation process of this invention avoids the use of chlorination reagents, expensive reagents, and heavy metal catalysts, reducing costs and process safety risks while ensuring yield, thus providing a more suitable route for the industrial production of the drug besudinil.

The present disclosure is directed to a method of treating a disease or disorder selected from the group consisting of heart disease, neurodegenerative disease, migraine headache, neurodevelopmental disease, infertility, pulmonary disease, muscle disease, liver disease, pancreatic disease, oral disease, ophthalmic disease, hearing disease, diseases of pregnancy, diseases of prematurity, aging disorders, movement disorders, infectious disease, and any disease in which Coenzyme Q declines, in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of 4-hydroxymandelic acid (4-HMA), 4-hydroxybenzoate (4-HB), or a compound of Formula (I); where R1, R2, R3, and R4 are as described herein. The present disclosure is also directed to a method of improving wound healing in a subject and a method of treating a neurodevelopmental disorder with spastic paresis and brain white matter abnormalities.