2 results about "Hydroxybenzoate" patented technology

The purpose of the present invention is to provide a method for producing hydroquinone that involves an enzyme that can convert p-hydroxybenzoic acid into hydroquinone at higher efficiencies than the 4-hydroxybenzoate 1-hydroxylase possessed by Candida parapsilosis strain CBS604. This purpose is achieved, for example, by a method for producing hydroquinone, the method comprising a step for obtaining hydroquinone by reacting p-hydroxybenzoic acid with a 4-hydroxybenzoate 1-hydroxylase derived from Spathaspora passalidarum.

This invention discloses a preparation process for the ROCK2 immunomodulator and its key intermediate. The invention uses methyl 3-hydroxybenzoate as a raw material to prepare the key intermediate compound E, and then further prepares besudinil and its salt through a substitution reaction of compound E with 5-aminoindazole. The preparation process of this invention avoids the use of chlorination reagents, expensive reagents, and heavy metal catalysts, reducing costs and process safety risks while ensuring yield, thus providing a more suitable route for the industrial production of the drug besudinil.